Composition with high moisturizing and soothing effects and application thereof

Abstract

The invention discloses a composition with high moisturizing and soothing effects. The composition is prepared from the following components: PEG-5-ethylhexanoate, sodium hyaluronate, a hydrolyzed algae extract, ribes nigrum seed oil and oat alkaloid. According to the composition with the high moisturizing and relieving effects and the preparation method thereof, a receptor related to a pruritus mechanism is adjusted through the synergistic effect of unique combinations through different mechanisms and the synergistic effect on two different mechanisms causing skin pruritus, the pruritus is relieved to the maximum extent on two different levels, the skin comfort degree is improved, and the composition has the good moisturizing and relieving effects. The itching feeling is obviously reduced, and skin discomfort caused by various factors is relieved; due to the addition of the two natural plant components, namely the hydrolyzed algae extract and the ribes nigrum seed oil, the moisturizing, soothing and repairing effects on the human skin are obvious, the skin barrier is repaired on the epidermal layer, and the skin resistance is consolidated; sodium hyaluronate is added, so that the skin elasticity is improved, the skin moisture is increased, and the full-effect moisturizing and soothing effects are achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to a composition with high moisturizing and soothing effects and a preparation method thereof. Background Art

[0002] Soothing agents play a role in reducing irritation and calming the skin in cosmetics. They can neutralize the active ingredients in cosmetics and block their irritation to the skin, thereby reducing allergic reactions such as redness, swelling, and itching. At the same time, soothing agents also have the effect of calming the skin, can relieve allergic symptoms caused by changes in the external environment, increase the mildness of cosmetics, and improve the safety and stability of products. The registration of plant raw materials and biotechnology raw materials has grown rapidly, which reflects the market's preference for natural and safe ingredients and the pursuit of innovative technology. The development trend of the cosmetics market in the past 3 to 5 years shows that the four major effects that consumers are concerned about are: brightening, moisturizing, improving fine lines, and anti-inflammatory soothing. In addition, data show that in the anti-inflammatory soothing effect classification, the proportion of soothing skin sensitivity is about 57.6%; for solving skin sensitivity problems, 56.9% of consumers are more concerned about safety and mildness; and consumers who care about repairing the skin barrier function account for 49.2%. In addition, in terms of online sales products, the number of registrations of anti-inflammatory soothing ingredients accounts for about 30%. The new product combines ingredients with different functions to form a variety of formula systems, allowing the product to develop from a single function to a comprehensive combination of popular functions such as anti-aging + repair + moisturizing; therefore, soothing effect has become a hot spot in market development.

[0003] The "Cosmetics Classification Rules and Classification Catalog" explains soothing as helping to improve skin irritation and other conditions, but does not describe the external causes of skin irritation and the skin problems induced. The problems induced by skin stimulation are mainly attributed to: 1. Skin barrier damage; 2. Skin inflammation; 3. Decreased moisturizing performance; 4. Increased nerve sensitivity. The main sources of irritation that cause skin irritation are: 1. Chemical irritation; 2. Microbial irritation; 3. Physical irritation. In recent years, the global economy has continued to develop and the living standards of residents have gradually improved, but environmental pollution, work pressure, life pressure, ultraviolet radiation, fast food diet, excessive makeup, electromagnetic radiation and other factors have also gradually increased the number of people with sensitive skin. Skin sensitivity mainly involves two aspects: internal factors (such as individual differences, physiological and psychological changes, etc.) and external factors (such as temperature, cold, heat, wind, sun, air conditioning, changes in humid air and dry air, complex cosmetic ingredients, etc.). Under the combined effect of the two, the probability of skin irritation and the degree of reaction have increased. In terms of the damaged skin repair process, it is usually necessary to start from four aspects: inhibition-anti-inflammatory-moisturizing-repair. However, the soothing and moisturizing products currently sold on the market are more reflected in the mildness and strong repair of the products. Many of them are still relatively weak in the combination of raw materials for sensitive skin, which is reflected in either insufficient moisturizing power, insufficient soothing effect, or too strong repair power. Normal skin uses hormone-containing products for a long time, and the metabolism is inhibited. The cells of the stratum corneum are continuously peeled off, and there is no new stratum corneum cell metabolism supplement. In other words, hormones make skin cells "die without rebirth". If this continues, the stratum corneum will gradually become thinner, like a peeled egg, resulting in the gradual loss of the epidermal barrier function. Therefore, there are still very few products that really have a moisturizing and soothing effect on the skin. Summary of the invention

[0004] The object of the present invention is to overcome at least one of the shortcomings of the prior art and to provide a composition with high moisturizing and soothing effects and a preparation method thereof.

[0005] The technical solution adopted by the present invention is:

[0006] In a first aspect, the present invention provides a composition with high moisturizing and soothing effects, the composition comprising the following components: PEG-5-ethylhexanoate, sodium hyaluronate, hydrolyzed algae extract, black tea seed oil, and oat alkaloids.

[0007] In some examples, the mass ratio of the components of the composition is: 0.5-5 parts of PEG-5-ethylhexanoate, 0.03-0.3 parts of sodium hyaluronate, 0.2-2 parts of hydrolyzed algae extract, 0.3-3 parts of black tea seed oil, and 0.01-0.1 parts of oat alkaloids.

[0008] In some examples, the mass ratio of the components of the composition is: 0.5 parts of PEG-5-ethylhexanoate, 0.03 parts of sodium hyaluronate, 0.2 parts of hydrolyzed algae extract, 0.3 parts of black tea seed oil, and 0.01 parts of oat alkaloids.

[0009] In some examples, the mass ratio of the components of the composition is: 2.5 parts of PEG-5-ethylhexanoate, 0.15 parts of sodium hyaluronate, 1 part of hydrolyzed algae extract, 1.5 parts of black tea seed oil, and 0.04 parts of oat alkaloids.

[0010] In some examples, the mass ratio of the components of the composition is: 5 parts of PEG-5-ethylhexanoate, 0.3 parts of sodium hyaluronate, 2 parts of hydrolyzed algae extract, 3 parts of black tea seed oil, and 0.1 parts of oat alkaloids.

[0011] In a second aspect, the composition provided in the first aspect of the present invention is used in skin care products, including auxiliary materials and functional ingredients, wherein the functional ingredients are the composition with high moisturizing and soothing effects.

[0012] In some examples, the mass addition amount of the highly moisturizing and soothing composition in the skin care product is 1.0 to 11.0%.

[0013] In some examples, the skin care product is a cream, lotion, water solution, essence, gel, or mask.

[0014] In some examples, the excipients include solvents, humectants, emulsifiers, chelating agents, and preservatives.

[0015] The beneficial effects of the present invention are:

[0016] The present invention is a composition with high moisturizing and soothing effects and a preparation method thereof, wherein the composition comprises PEG-5-ethylhexanoate, sodium hyaluronate, hydrolyzed algae extract, black tea seed oil, and oat alkaloids. The oat alkaloids (interaction between mast cells and nerve endings distributed in the dermis) + PEG-5-ethylhexanoate (interaction between keratinocytes and nerve endings distributed in the epidermis) act synergistically through different mechanisms in a unique combination, and the natural inspiration molecules selected from 40 avenanthramide synthetic derivatives regulate itching in two complementary action modes at different levels. The nerve sensory chain reaction of the source, through the synergistic effect on the two different mechanisms of skin itching, regulates the receptors involved in the itching mechanism, relieves itching to the greatest extent and improves skin comfort at two different levels, significantly reduces the itching sensation, and relieves skin discomfort induced by various factors; and the addition of two natural plant ingredients, hydrolyzed algae extract and black tea seed oil, has a significant effect on moisturizing, soothing and repairing human skin, repairs the skin barrier in the epidermis, and consolidates skin resistance; sodium hyaluronate is added to improve skin elasticity and increase skin moisture, achieving a full-effect moisturizing and soothing effect. The present invention proves the effectiveness of the composition of the present invention through a large number of experiments, and each component is irreplaceable. The addition range of the composition of the present invention is also an optimal range, which is an optimal range in terms of effect and cost. In summary, the composition of the present invention is an economical and effective composition with moisturizing and soothing functions. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 The redness images of volunteers before and after using the product of Example 1 using Antera 3D multifunctional 3D skin imaging analyzer.

[0018] Figure 2 The redness images of volunteers before and after using the product of Example 2 using the Antera 3D multifunctional 3D skin imaging analyzer.

[0019] Figure 3 The redness images of volunteers before and after using the product of Example 3 using the Antera 3D multifunctional 3D skin imaging analyzer.

[0020] Figure 4 The redness images of volunteers before and after using the product of Comparative Example 4 using the Antera 3D multifunctional 3D skin imaging analyzer.

[0021] Figure 5 The redness images of volunteers before and after using the product of Comparative Example 5 using the Antera 3D multifunctional 3D skin imaging analyzer.

[0022] Figure 6The redness images of volunteers before and after using the product of Comparative Example 6 using the Antera 3D multifunctional 3D skin imaging analyzer. DETAILED DESCRIPTION

[0023] The following disclosure provides many different embodiments or examples for implementing different solutions of the present invention.

[0024] Black Camellia Seed Oil: Organically grown and extracted with supercritical CO2, it has a high content of ω-3 / 6 fatty acids. Its linoleic acid helps to form type I ceramides to improve the skin barrier, while γ-linolenic acid promotes the production of prostaglandins with anti-inflammatory effects (patients with specific hereditary eczema often have a deficiency of D-6-dehydrogenase). Linoleic acid prevents the formation of pro-inflammatory leukotrienes by inhibiting 5-lipoxygenase, thereby strengthening the skin barrier, relieving inflammation, soothing the skin, reducing red areas, and improving the overall appearance of skin with red bloodshot.

[0025] Oat alkaloids: Naturally present in oats, dihydroaat alkaloid D has the ability to regulate NK1 (1. Neurokinin substance P receptor, a member of the G protein-coupled receptor family (GPCR); 2. Blocking the binding of NK1 receptors on mast cells to substance P, which can regulate the itching and inflammatory response mediated by the release of histamine by mast cells; 3. DHAvD has a binding antagonistic fusion domain between 5-6 transmembrane;) receptors, thereby inhibiting the release of itching mediators (such as histamine) in a dose-dependent manner. It is a well-known skin soothing agent.

[0026] Hydrolyzed algae extract: It is extracted from a single-cell red algae with high-efficiency active ingredients from the ocean. Red cystspore algae can effectively reduce skin sensitivity and keep the skin comfortable. It is not only soothing, but also an innovative product in the recent neurocosmetics market. It reduces skin sensitivity, inflammation and neuroinflammation by inhibiting the expression of TRPV1. It is a neurocosmetic solution to reduce skin discomfort.

[0027] PEG-5-ethylhexanoate: An ester used to relieve skin itching symptoms. It achieves its effect by regulating PAR-2 ​​(1. Protein kinase receptor-2, a member of the G protein-coupled receptor family (GPCR); 2. Widely expressed in the central nervous system (including neurons, microglia and astrocytes), and highly expressed in activated astrocytes) located at the sensory nerve endings.

[0028] Sodium hyaluronate: Hyaluronic acid can penetrate into the epidermis of the skin, promote the supply of nutrients to the skin and the excretion of waste, thereby preventing skin aging and repairing and preventing skin damage: by promoting the proliferation and differentiation of epidermal cells and scavenging oxygen free radicals, it can promote the regeneration of skin in injured areas, protect the skin, enhance skin moisture, reduce the penetration of ultraviolet rays and repair skin damage caused by a small amount of ultraviolet rays that penetrate.

[0029] The types of raw materials prepared in the following examples of the present invention and their mass fraction compositions are as follows:

[0030] Category A: Cetearyl Alcohol 3%, Glyceryl Stearate 2%, Dimethicone 4%, Tocopheryl Acetate 1%, Shea Butter 4%, Phytosteryl / Octyldodecyl Lauroyl Glutamate 2%, Pentaerythrityl Tetra(Ethylhexanoate) 5%, Synthetic Wax 0.9%, Stearic Acid 0.3%;

[0031] Category B: Hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer 0.3%, glycerin 5%, disodium EDTA 0.05%, allantoin 0.1%, 1,2-pentanediol 1.5%, 1,2-hexanediol 0.5%, PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin 0.3%, after removing all the raw materials in categories A, B (excluding water), C, D, E, F, and G, the remaining is water;

[0032] Category C: Polyacrylate-13 polyisobutylene 0.8%;

[0033] Category D: arginine 0.15%, water 1.5%;

[0034] Category E: p-hydroxyacetophenone 0.5%, butanediol 2%;

[0035] Category F: Sodium hyaluronate, 3% water;

[0036] Category G: Nigella Sativa seed oil, avena sativa alkaloids, hydrolyzed algae extract, PEG-5-ethylhexanoate.

[0037] The specific compositions of the sodium hyaluronate of type F and the compounds of type G in different examples are shown in Table 1 below:

[0038] Table 1

[0039]

[0040] The specific formula composition of the comparative example is as follows:

[0041] 1. Comparative Example 1 is to replace black tea seed oil, oat alkaloids, hydrolyzed algae extract, PEG-5-ethylhexanoate, and sodium hyaluronate with 2% bisabolol, and the remaining auxiliary material components are the same as those in Example 2;

[0042] 2. In comparative example 1, black tea seed oil, oat alkaloids, hydrolyzed algae extract, PEG-5-ethylhexanoate, and sodium hyaluronate are replaced with 5% aloe vera, and the remaining auxiliary material components are the same as those in example 2;

[0043] 3. Comparative Example 3 is an essence cream obtained by removing the sodium hyaluronate from the essence cream of Example 2 of the present invention.

[0044] 4. Comparative Example 4 is an essence cream obtained by removing PEG-5-ethylhexanoate from the essence cream of Example 2 of the present invention.

[0045] 5. Comparative Example 5 is an essence cream obtained by removing the hydrolyzed algae extract from the essence cream of Example 2 of the present invention.

[0046] 6. Comparative Example 6 is an essence cream obtained by removing the black camellia seed oil from the essence cream of Example 2 of the present invention.

[0047] 7. Comparative Example 7 is an essence cream obtained by removing the oat alkaloids from the essence cream of Example 2 of the present invention.

[0048] 8. Comparative Example 8 is an international brand moisturizing and soothing essence cream with good sales and reputation on the market.

[0049] The preparation method of the essence cream of each example is as follows:

[0050] 1. Add ingredient A into a container, stir and heat until the solid is completely dissolved.

[0051] 2. Add raw material D into the container and dissolve it for later use.

[0052] 3. Add raw material E into the container, stir and heat to 60-70 degrees until dissolved and set aside.

[0053] 4. Add raw material F into the container and dissolve it for later use.

[0054] 5. Add raw materials 10 and 11 to a dry container, stir and disperse evenly, then add raw materials 12-18. After homogenization, slowly add raw material C phase, continue homogenization for 10-15 minutes to make the material uniform, then add phase D and stir for 10-15 minutes and cool down.

[0055] 6. When the temperature drops below 45 degrees, add phases E, F, and G and homogenize for 6-10 minutes to make the material uniform before discharging.

[0056] Efficacy Test

[0057] 1. Test equipment:

[0058] 1. Take photos using Delfin Antera 3D from Finland. Antera3D uses innovative optical methods and complex mathematical algorithms to obtain three-dimensional images. This allows data to be extracted from images related to the three-dimensional shape of the skin, which will be able to quantify the effects of treatment and monitor changes over time. For example, measure the texture, smoothness, and depth and width of fine lines and wrinkles of the skin. With its multispectral analysis, Antera software can also measure pigmentation and redness, which will provide meaningful information about sun damage, veins, etc.

[0059] 2. Use the Finnish Moisture Meter SC skin stratum corneum moisture meter to measure the hydration value of the stratum corneum on the skin surface. Moisture Meter SC can be used in skin research, service laboratories, promotion and marketing of skin care products, as well as product development and claim confirmation in the pharmaceutical and personal care industries. Its probe head, skin surface and deeper skin layers form a capacitor-like structure. The measured capacitance is proportional to the water content of the skin surface layer. A higher measured value indicates a higher water content in the stratum corneum, giving important information about the biophysical properties and functions of the skin barrier, and can check the effects of skin care and different skin care products on the skin.

[0060] 3. Use the Finnish Delfin VapoMeter SWL5201 transepidermal water loss meter. The VapoMeter has a cylindrical chamber with relative humidity and temperature sensors inside. Shortly after the instrument is in contact with the skin, the relative humidity (RH%) in the measurement chamber increases linearly. The TEWL value is calculated based on the increase in RH%. In the measurement interval, the measurement chamber is passively ventilated. The VapoMeter uses the closed chamber measurement principle, so the measurement is not affected by the air flow in the room. The short measurement time ensures that the blocking of normal evaporation is minimized.

[0061] 2. Experimental Principle:

[0062] 1. TEWL value, transepidermal water loss (TEWL) measures the change in water vapor pressure near the skin surface. The TEWL value indicates the loss of water from the stratum corneum and is an important criterion for evaluating the barrier function of the stratum corneum. The lower the TEWL value of the skin, the better the barrier function of the skin, and vice versa. By testing the TEWL value of skin water loss, the efficacy of moisturizing and repairing cosmetics can be evaluated. It can also be used in allergic patch tests, contact dermatitis, physical therapy, burns and monitoring of new tissue to promptly detect whether the protective function of the skin has been destroyed. The unit of TEWL is: g / hm 3 .

[0063] 2. SCH value, skin stratum corneum moisture value measures the moisture content of the skin itself, so as to determine the health of the skin. The skin is an electrically layered structure, and the electrical properties of these layers are related to their water content. The probe head, the skin surface and the deeper skin layers form a structure similar to a capacitor, and the measured capacitance is related to the skin

[0064] The water content of the surface layer is proportional. The higher the SCH value of the stratum corneum of the skin, the more water there is in the stratum corneum of the skin, and the better the moisturizing performance of the product, and vice versa. The hydration measurement value of the stratum corneum of the skin can be used to evaluate the efficacy of moisturizing and repairing cosmetics, and can also be used to obtain important information on the biophysical properties and functions of the skin barrier.

[0065] 3. Test population:

[0066] There are 10 groups with 26 people in each group, including volunteers aged 18-65 who meet the experimental requirements.

[0067] 4. Test conditions:

[0068] At room temperature of 21±1°C and relative humidity of 50±10%, real-time dynamic monitoring was performed and the subjects sat quietly for 30 minutes before relevant data were tested.

[0069] 5. Experimental process:

[0070] The experiment was divided into 10 groups. The first group used Example 1 of the present invention on the whole face, the second group used Example 3 of the present invention on the whole face, the third group used Comparative Example 8 on the whole face, the 4-10 groups used Example 2 of the present invention on the left face, and each group applied Comparative Examples 1-7 on the right face; the face was rubbed twice a day in the morning and evening for 4 weeks, and the transepidermal water loss rate TEWL value and the stratum corneum water content SCH value of the skin were observed, and then each volunteer's left and right cheeks were photographed with Antera 3D, and the photos were archived. The experimental results Figure 1-6 .

[0071] Experimental results:

[0072] 1. Transepidermal water loss (TEWL) test

[0073] In this test, the TEWL measured by the subjects in week 0 is set as TEWL0, and the TEWL in week 4 is set as TEWL4. The TEWL change value is △TEWL, △TEWL = TEWL4-TEWL0, △TEWL change rate = (TEWL4-TEWL0) / TEWL0*100%, and the △TEWL change rate is a negative number. The lower the value, the less water loss of the skin after four weeks of use, that is, the better the skin barrier function is repaired, the better the skin retains moisture, and the healthier the skin. Table 2 shows the average △TEWL change rate value of 26 people in each group compared with the initial value after 4 weeks of use, as follows:

[0074] Table 2

[0075]

[0076]

[0077] Experimental results:

[0078] From the experimental results in Table 2, we can see that:

[0079] 1. △TEWL change rate value, Example 1> Example 2> Example 3, which shows that as the addition ratio of the composition of the present invention increases, the △TEWL change rate value will become smaller accordingly, that is, the less the skin moisture loss is, the more complete the stratum corneum barrier function of the skin is, the better the skin's ability to resist external environmental damage is, the less likely the skin is to lose moisture, and the skin will be healthier, more hydrated, and fuller.

[0080] 2. The △TEWL change rate value of Comparative Example 1 is greater than that of Example 2, indicating that when the composition of the present invention is replaced with bisabolol, the water loss of the skin increases, which means that the barrier function of the stratum corneum of the skin is weakened and water is more easily lost.

[0081] 3. The △TEWL change rate value of Comparative Example 2 is greater than that of Example 2, indicating that when the composition of the present invention is replaced with Aloe vera, the water loss of the skin increases, that is, the barrier function of the stratum corneum of the skin is weakened, and water is more easily lost.

[0082] 4. Comparative Examples 3-7 are essence creams made by removing any one of the compositions of the present invention in Example 2. By comparing with Example 2, their △TEWL change rates are all greater than that of Example 2. Therefore, it can be explained that arbitrarily removing any component in the composition of the present invention will increase the corresponding △TEWL value, that is, the skin moisture is more easily lost, and the recovery of the skin's stratum corneum barrier function is not as good as that of Example 2.

[0083] 5. The △TEWL change rate values ​​of Examples 1-3 are all smaller than those of Comparative Example 8, which indicates that the ability of the composition of the present invention to reduce skin moisture loss within the range of added amount is better than that of the anti-aging essence cream of international brands on the market, and the ability to maintain skin moisture and repair the skin stratum corneum barrier is also better than that of the moisturizing soothing cream of commercially available brands.

[0084] 2. Change rate of SCH value of skin stratum corneum water content

[0085] In this test, the SCH of the subjects measured in week 0 is set as ISE0, the SCH of week 4 is set as SCH4, and the SCH change value is △SCH, △SCH = SCH4-SCH0, △SCH change rate = (SCH4-SCH0) / SCH0*100%, and the △SCH change rate is a positive number. The higher the value, the more the skin hydration value increases after four weeks of using the product, the higher the skin moisture, and the firmer, plumper and more elastic the skin. Table 3 shows the average △SCH change rate value of 26 people in each group compared with the initial value after 4 weeks of use, as follows:

[0086] Table 3

[0087]

[0088] From the experimental results in Table 3, we can see that:

[0089] △SCH change rate value, Example 1 < Example 2 < Example 3, which shows that as the addition ratio of the composition of the present invention increases, the change rate of its moisture value also increases significantly. Therefore, it means that within the addition range of the composition of the present invention, the higher the addition amount of each component, the more the moisture of the skin increases, and the more moisturized and plump the skin is.

[0090] The ΔSCH change rate value of Comparative Example 1 is less than that of Example 2, which indicates that even if the composition of the present invention is replaced with bisabolol, a star ingredient for moisturizing and soothing on the market, and the amount of bisabolol added is relatively high, the effect of increasing skin moisturizing and soothing is still not as good as the composition of the present invention.

[0091] The ΔSCH change rate value of Comparative Example 2 is less than that of Example 2, which indicates that even if the composition of the present invention is replaced with Aloe vera, which is widely used on the market, and the added amount is similar to that in Example 2, the effect of increasing skin moisturizing and soothing is still far inferior to that of the composition of the present invention.

[0092] Comparative Examples 3-7 are essence creams made by removing any of the compositions of the present invention in Example 2. By comparing with Example 2, their △SCH change rates are all smaller than those of Example 2. Therefore, it can be explained that arbitrarily removing any component in the composition of the present invention will reduce the corresponding △SCH change rate value, and the increase in skin moisture is not as good as that in Example 2 of the present invention.

[0093] The ΔSCH change rate values ​​of Examples 1-3 are all greater than that of Comparative Example 8, which indicates that the ability of the composition of the present invention to increase skin moisture within the range of added amount is better than that of the moisturizing soothing cream of commercially available brands, and the cosmetics made using the composition of the present invention have a more excellent effect of increasing skin moisture.

[0094] Safety test (human skin patch test)

[0095] 1. Number of testers: 35 people in total, including 16 males and 19 females, aged between 18 and 60 years old.

[0096] 2. Health status: The subject has healthy skin, no history of skin allergies, and meets the voluntary inclusion criteria.

[0097] 3. Test method: Select a qualified patch tester and use a closed patch test method. Place about 0.020-02025g of the test product in the patch tester and cover it on the back of the subject with special adhesive tape. Each subject has 11 application points. Remove the test article after 24 hours and observe the skin reaction 0.5, 24, and 48 hours after removal. Score according to the skin reaction grading standard in the "Cosmetic Hygiene Standards" and calculate the average value.

[0098] 4. The evaluation criteria are shown in Table 4 and the experimental results are shown in Table 5.

[0099] Table 4 Human skin patch test standard table

[0100]

[0101] Table 5 Skin patch test scoring results

[0102] Rating 0.5(h) 24(h) 48(h) Example 1 0 0 0 Example 2 0 0 0 Example 3 0 1 0 Comparative Example 1 1 0 1 Comparative Example 2 0 1 0 Comparative Example 3 0 0 0 Comparative Example 4 0 0 0 Comparative Example 5 0 0 0 Comparative Example 6 0 0 0 Comparative Example 7 0 0 0 Comparative Example 8 1 1 0

[0103] It can be seen from Table 5 that the various components of the composition of the present invention are very safe, very friendly to the skin, mild and non-irritating, while Comparative Example 1 has a relatively strong irritation.

[0104] The above is a further detailed description of the present invention, which should not be regarded as a limitation on the specific implementation of the present invention. For ordinary technicians in the technical field to which the present invention belongs, simple deduction or replacement without departing from the concept of the present invention is within the protection scope of the present invention.

Claims

1. A composition with high moisturizing and soothing effects, characterized in that: The composition comprises the following components: PEG-5-ethylhexanoate, sodium hyaluronate, hydrolyzed algae extract, black tea seed oil, and oat alkaloids.

2. The composition according to claim 1, characterized in that The mass ratio of the components of the composition is: 0.5-5 parts of PEG-5-ethylhexanoate, 0.03-0.3 parts of sodium hyaluronate, 0.2-2 parts of hydrolyzed algae extract, 0.3-3 parts of black tea seed oil, and 0.01-0.1 parts of oat alkaloids.

3. The composition according to claim 1, characterized in that The mass ratio of the components of the composition is: 0.5 parts of PEG-5-ethylhexanoate, 0.03 parts of sodium hyaluronate, 0.2 parts of hydrolyzed algae extract, 0.3 parts of black tea seed oil, and 0.01 parts of oat alkaloids.

4. The composition according to claim 1, characterized in that The mass ratio of the components of the composition is: 2.5 parts of PEG-5-ethylhexanoate, 0.15 parts of sodium hyaluronate, 1 part of hydrolyzed algae extract, 1.5 parts of black tea seed oil, and 0.04 parts of oat alkaloids.

5. The composition according to claim 1, characterized in that The mass ratio of the components of the composition is: 5 parts of PEG-5-ethylhexanoate, 0.3 parts of sodium hyaluronate, 2 parts of hydrolyzed algae extract, 3 parts of black tea seed oil, and 0.1 parts of oat alkaloids.

6. Use of the composition according to any one of claims 1 to 5 in skin care products, characterized in that: It comprises auxiliary materials and functional ingredients, wherein the functional ingredients are the composition with high moisturizing and soothing effects.

7. The use according to claim 6, characterized in that: The mass addition amount of the composition with high moisturizing and soothing effects in skin care products is 1.0-11.0%.

8. The use according to claim 6, characterized in that: The skin care products are creams, lotions, water solutions, essences, gels, and facial masks.

9. The use according to claim 6, characterized in that: The auxiliary materials include solvents, moisturizers, emulsifiers, chelating agents and preservatives.

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