4-lauryl-beta-lactam derivative and preparation method thereof

Abstract

The invention discloses a 4-lauryl-beta-lactam derivative and a preparation method thereof, the structural formula of the 4-lauryl-beta-lactam derivative is as follows: # imgabs0 #, and R1 and R2 are independently selected from one of hydrogen, C1-C6 saturated or unsaturated alkyl, and substituted or unsubstituted benzyl. According to the method, the high-yield 4-lauryl-beta-lactam derivative can be constructed by simple raw materials in one step, the reaction condition is mild, the post-treatment process is simple, and the method is suitable for large-scale production.

Description

Technical Field

[0001] The invention relates to the field of organic synthesis, and in particular to a 4-lauryl-β-lactam derivative and a preparation method thereof. Background Art

[0002] β-lactam is an important component of N-heterocycles. Some natural products and drug molecules have this core skeleton. In particular, the monocyclic four-membered nitrogen-containing heterocyclic antibiotics used in clinical practice have become specific drugs for the treatment of diseases such as pancreatitis.

[0003] To date, the main methods for synthesizing β-lactam derivatives are: (1) preparing β-lactam derivatives by reduction ring-closure reaction (J.Org.Chem.1995,60,1276); (2) synthesizing β-lactams by CH bond activation and metal catalysis (Angewandte Chemie 2014,53,3496); (3) synthesizing β-lactams by free radical-promoted addition ring-forming reaction (Chem.Common.2019,55,10523); (4) synthesizing β-lactams by free radical cascade carbon amination reaction of unactivated double bonds (J.Am.Chem.Soc.2021,143,1195-1202); However, the free radicals introduced in the above molecules usually have special structures and cannot achieve efficient coupling of large-volume straight-chain hydrocarbon groups. In addition, the pre-preparation and addition of additional oxidants and the generation of free radical donor by-products do not meet the requirements of high efficiency, atom economy and environmental friendliness. Based on this, there is an urgent need for a method that can efficiently construct different β-lactam derivatives. Summary of the invention

[0004] The technical problem to be solved by the present invention is to provide a 4-lauryl-β-lactam derivative and a preparation method thereof. By initiating a tandem cyclization reaction of dilauroyl peroxide, the 4-lauryl-β-lactam derivative can be efficiently synthesized. The method has a simple preparation process, mild reaction conditions, high atom utilization rate and good universality, conforms to green chemistry, and is suitable for large-scale production.

[0005] In order to solve the above technical problems, the first aspect of the present invention provides a 4-lauryl-β-lactam derivative, the structural formula of the 4-lauryl-β-lactam derivative is shown in IV:

[0006]

[0007] Among them, R 1 , R 2 Independently selected from one of hydrogen, C1-C6 saturated or unsaturated alkyl, and substituted or unsubstituted benzyl.

[0008] Furthermore, R 1 , R2 are independently selected from hydrogen, methyl, ethyl, allyl, cyclopropylmethyl, benzyl or p-methylbenzyl.

[0009] Furthermore, the 4-lauryl-β-lactam derivative is selected from the structures shown in formulas IV-1 to IV-8:

[0010]

[0011] The second aspect of the present invention provides a method for preparing the 4-lauryl-β-lactam derivative described in the first aspect, comprising:

[0012] reacting the compound represented by formula (I) and the compound represented by formula (II) in the presence of a metal salt catalyst and a solvent to obtain the 4-lauryl-β-lactam derivative;

[0013] The structures of the compound represented by the above formula (I) and the compound represented by the above formula (II) are shown below:

[0014]

[0015] Among them, R 1 , R 2 Independently selected from one of hydrogen, C1-C6 saturated or unsaturated alkyl, and substituted or unsubstituted benzyl.

[0016] Further, the compound represented by formula (I) is selected from N-(5-iodoquinolin-8-yl)-3-butenamide, N-(5-iodoquinolin-8-yl)-2-methyl-3-butenamide, 2-ethyl-N-(5-iodoquinolin-8-yl)-3-butenamide, N-(5-iodoquinolin-8-yl)-2,2-dimethyl-3-butenamide, N-(5-iodoquinolin-8-yl)-2-vinyl-4-pentenamide, 2-(cyclopropylmethyl)-N-(5-iodoquinolin-8-yl)-3-butenamide, 2-benzyl-N-(5-iodoquinolin-8-yl)-3-butenamide, N-(5-iodoquinolin-8-yl)-2-(4-methylbenzyl)-3-butenamide, and the structural formulas are shown below:

[0017]

[0018] Furthermore, the metal salt catalyst is selected from one or more of cuprous bromide, cuprous iodide, cupric acetate, cuprous chloride, tetraacetonitrile copper hexafluorophosphate, and cuprous trifluoromethanesulfonate.

[0019] Preferably, the metal catalyst is selected from one or more of cuprous iodide, copper hexafluorophosphate tetraacetonitrile, and cuprous trifluoromethanesulfonate.

[0020] Furthermore, the solvent is selected from one or more of acetonitrile, toluene, dichloromethane, 1,2-dichloroethane, 1,4-dioxane, methyl tert-butyl ether, and tetrahydrofuran.

[0021] Furthermore, the molar ratio of the compound represented by formula (I), the compound represented by formula (II), the metal salt catalyst and the solvent is 1:1-3:0.02-0.7; preferably 1:1-3:0.05-0.2; for example, the molar ratio of the compound represented by formula (I), the compound represented by formula (II) and the metal salt catalyst is 1:2:0.2, 1:2:0.02, 1:2:0.7, 1:2:0.1.

[0022] Furthermore, the ratio of the molar amount of the compound represented by the formula (I) to the volume of the solvent is 1mmol:(5-30)mL, for example 1mmol:5mL, 1mmol:10mL, 1mmol:15mL, 1mmol:20mL, 1mmol:25mL, 1mmol:30mL, etc.

[0023] Further, the reaction temperature is 60-100°C; for example, 60°C, 70°C, 80°C, 90°C, 100°C, etc., including but not limited to the temperatures listed above.

[0024] Beneficial effects of the present invention:

[0025] 1. The present invention provides a method for preparing the above-mentioned 4-lauryl-β-lactam derivatives, which uses N-(5-iodoquinoline-3-buteneamide derivatives and dilauroyl peroxide as reactants, and utilizes the double bond free radical addition cyclization reaction promoted by lauroyl free radicals to efficiently synthesize 4-lauryl-β-lactam derivatives; the method has easy-to-obtain raw materials, high atom utilization rate, good universality and is green and environmentally friendly, and is suitable for the batch preparation of β-lactam derivatives.

[0026] 2. The 4-lauryl-β-lactam derivative provided by the present invention can increase the lipid solubility of the molecule by introducing a bulky straight-chain alkyl group into the β-lactam molecule, which is beneficial to the diffusion of the small molecule drug in the body and increases the concentration of the active substance reaching the target site. DETAILED DESCRIPTION

[0027] The present invention is further described below in conjunction with specific embodiments so that those skilled in the art can better understand the present invention and implement it, but the embodiments are not intended to limit the present invention.

[0028] Example 1: Synthesis of the compound represented by formula IV-1

[0029]

[0030] Weigh N-(5-iodoquinolin-8-yl)-3-buteneamide (0.068 g, 0.20 mmol of the compound shown in formula (1)), CuOTf (0.004 g, 0.04 mmol) and dissolve them in 2 mL of tetrahydrofuran, and add dodecanoyl peroxide (0.159 g, 0.40 mmol). Heat the mixture to 80°C for reaction, and track the reaction by TLC until the reaction is completely completed. After the reaction is completed, the crude product is purified by silica gel column chromatography (petroleum ether: ethyl acetate = 20:1) to obtain product IV-1, and the separation yield is 49%.

[0031] The above IV-1 was characterized by NMR, and the results were:

[0032] 1 H NMR(400MHz,Chloroform-d)δ8.80(dd,J=4.1,1.7Hz,1H),8.35(dd,J=8.6,1.6Hz,1H), 8.05(s,2H),7.47(dd,J=8.6,4.1Hz,1H),5.14(ddt,J=8.8,5.7,3.0Hz,1H),3.31(dd,J =15.1,5.4Hz,1H),2.80(dd,J=15.1,2.6Hz,1H),1.95(dddd,J=12.8,9.3,6.3,3.3Hz,1 H), 1.47 (ddd, J=14.6, 11.2, 6.9Hz, 1H), 1.22 (d, J=14.0Hz, 20H), 0.87 (t, J=6.8Hz, 3H).

[0033] 13 C NMR(101MHz,Chloroform-d)δ166.74,149.41,140.41,137.71,134.88,122.91,122.49,91.95 ,56.80,43.23,33.62,31.92,29.65,29.62,29.49,29.42,29.35,29.33,24.97,22.70,14.14.

[0034] Example 2: Synthesis of the compound represented by formula IV-1

[0035] Weigh N-(5-iodoquinolin-8-yl)-3-buteneamide (0.068 g, 0.20 mmol of the compound shown in formula (1)), CuOTf (0.004 g, 0.04 mmol) and dissolve them in 2 mL of tetrahydrofuran, and add dodecanoyl peroxide (0.159 g, 0.40 mmol). Heat the mixture to 60°C for reaction, and track the reaction by TLC until the reaction is completely completed. After the reaction is completed, the crude product is purified by silica gel column chromatography (petroleum ether: ethyl acetate = 20:1) to obtain product IV-1, and the separation yield is 36%.

[0036] Example 3: Synthesis of the compound represented by formula IV-1

[0037] Weigh N-(5-iodoquinolin-8-yl)-3-buteneamide (0.068 g, 0.20 mmol of the compound shown in formula (1)), CuOTf (0.004 g, 0.04 mmol) and dissolve them in 2 mL of tetrahydrofuran, and add dodecanoyl peroxide (0.159 g, 0.40 mmol). Heat the mixture to 100°C for reaction, and track the reaction by TLC until the reaction is completely completed. After the reaction is completed, the crude product is purified by silica gel column chromatography (petroleum ether: ethyl acetate = 20:1) to obtain product IV-1, and the separation yield is 45%.

[0038] Example 4: Synthesis of the compound represented by formula IV-1

[0039] Weigh N-(5-iodoquinolin-8-yl)-3-buteneamide (0.068 g, 0.20 mmol of the compound shown in formula (1)), Cu(CH3CN)4PF6 (0.015 g, 0.04 mmol) and dissolve them in 2 mL of tetrahydrofuran, and add dodecanoyl peroxide (0.159 g, 0.40 mmol). Heat the mixture to 100°C for reaction, and track the reaction by TLC until the reaction is completely completed. After the reaction is completed, the crude product is purified by silica gel column chromatography (petroleum ether: ethyl acetate = 20:1) to obtain product IV-1, and the separation yield is 15%.

[0040] Example 5: Synthesis of the compound represented by formula IV-1

[0041] Weigh N-(5-iodoquinolin-8-yl)-3-buteneamide (0.068 g, 0.20 mmol of the compound shown in formula (1)), CuOTf (0.014 g, 0.14 mmol) and dissolve them in 2 mL of tetrahydrofuran, and add dodecanoyl peroxide (0.159 g, 0.40 mmol). Heat the mixture to 80°C for reaction, and track the reaction by TLC until the reaction is completely completed. After the reaction is completed, the crude product is purified by silica gel column chromatography (petroleum ether: ethyl acetate = 20:1) to obtain product IV-1, and the separation yield is 39%.

[0042] Example 6: Synthesis of the compound represented by formula IV-1

[0043] Weigh N-(5-iodoquinolin-8-yl)-3-buteneamide (0.068 g, 0.20 mmol of the compound shown in formula (1)), CuI (0.004 g, 0.02 mmol) and dissolve them in 2 mL of tetrahydrofuran, and add dodecanoyl peroxide (0.159 g, 0.40 mmol). Heat the mixture to 80°C for reaction, and track the reaction by TLC until the reaction is completely completed. After the reaction is completed, the crude product is purified by silica gel column chromatography (petroleum ether: ethyl acetate = 20:1) to obtain product IV-1, and the separation yield is 10%.

[0044] Example 7: Synthesis of the compound represented by formula IV-2

[0045]

[0046] Weigh N-(5-iodoquinolin-8-yl)-2-methyl-3-buteneamide (0.070 g, 0.20 mmol of the compound shown in formula (2)), CuOTf (0.004 g, 0.04 mmol) and dissolve them in 2 mL of tetrahydrofuran, and add dodecanoyl peroxide (0.159 g, 0.40 mmol). Heat the mixture to 80°C for reaction, and track the reaction by TLC until the reaction is completely completed. After the reaction is completed, the crude product is purified by silica gel column chromatography (petroleum ether: ethyl acetate = 20:1) to obtain compound IV-2, with an isolation yield of 43%.

[0047] The above IV-2 was characterized by NMR, and the results were:

[0048] 1 H NMR(400MHz,Chloroform-d)δ8.80(dd,J=4.1,1.7Hz,1H),8.35(dd,J=8.6,1.6Hz,1H),8.05(s,2H),7.47(dd,J=8.6,4.1Hz,1H),4.75(dt,J=9.4,2. 8Hz, 1H), 3.00 (qd, J=7.3, 2.4Hz, 1H), 1.96 (dddd, J=12.2, 8.9, 5.8, 3.1Hz ,1H),1.48(d,J=7.4Hz,4H),1.23(d,J=9.2Hz,20H),0.87(t,J=6.8Hz,3H).

[0049] 13C NMR(101MHz,Chloroform-d)δ170.24,149.34,140.36,137.70,134.82,122.85,122.65,65.22 ,51.11,33.35,31.92,29.66,29.63,29.50,29.42,29.41,29.35,25.20,22.70,14.13,13.81.

[0050] Example 8: Synthesis of the compound represented by formula IV-3

[0051]

[0052] Weigh 2-ethyl-N-(5-iodoquinolin-8-yl)-3-buteneamide (0.073 g, 0.20 mmol of the compound shown in formula (3)), CuOTf (0.004 g, 0.04 mmol) and dissolve in 2 mL of tetrahydrofuran, and add dodecanoyl peroxide (0.159 g, 0.40 mmol). Heat the mixture to 80°C for reaction, and track the reaction by TLC until the reaction is completely completed. After the reaction is completed, the crude product is purified by silica gel column chromatography (petroleum ether: ethyl acetate = 20:1) to obtain compound IV-3, and the separation efficiency is 39%.

[0053] The above IV-3 was characterized by NMR, and the results were:

[0054] 1 H NMR (400MHz, Chloroform-d) δ8.80 (dd, J=4.1, 1.6Hz, 1H), 8.34 (dd, J=8.6, 1.6Hz, 1H), 8.06 (q, J=8.2Hz, 2H), 7.46 (dd, J=8.6, 4.1Hz, 1H), 4.83 (dt, J=9. 3, 2.8Hz, 1H), 2.92 (ddd, J=8.4, 5.9, 2.3Hz, 1H), 2.05–1.80 (m, 3H), 1.55–1. 41(m,1H),1.34–1.17(m,20H),1.12(t,J=7.4Hz,3H),0.87(t,J=6.8Hz,3H).

[0055] 13C NMR(101MHz,Chloroform-d)δ169.77,149.32,140.34,137.71,134.85,130.50,122.83,122.55,91.66,6 3.23,58.00,33.41,31.92,29.65,29.63,29.50,29.45,29.41,29.35,25.25,22.70,22.28,14.14,11.94.

[0056] Example 9: Synthesis of the compound represented by formula IV-4

[0057]

[0058] Weigh N-(5-iodoquinolin-8-yl)-2,2-dimethyl-3-buteneamide (0.073 g, 0.20 mmol of the compound shown in formula (4)), CuOTf (0.004 g, 0.04 mmol) and dissolve them in 2 mL of tetrahydrofuran, and add dodecanoyl peroxide (0.159 g, 0.40 mmol). Heat the mixture to 80°C for reaction, and track the reaction by TLC until the reaction is completely completed. After the reaction is completed, the crude product is purified by silica gel column chromatography (petroleum ether: ethyl acetate = 20:1) to obtain compound IV-4, with an isolation yield of 56%.

[0059] The above IV-4 was characterized by NMR, and the results were:

[0060] 1 H NMR(400MHz,Chloroform-d)δ8.80(dd,J=4.2,1.7Hz,1H),8.33(dd,J=8.6,1.6Hz,1H),8.10–7.91(m,2H),7.46(dd,J=8.6,4.1Hz,1 H),4.82(dd,J=10.0,3.6Hz,1H),1.84–1.74(m,1H),1.57–1.47(m,4H),1.34(s,3H),1.22(d,J=12.0Hz,20H),0.87(t,J=6.8Hz,3H).

[0061] 13C NMR(101MHz,Chloroform-d)δ173.45,149.41,140.34,137.64,134.58,130.53,123.53,122.85,68.54,5 3.17,31.92,29.74,29.67,29.64,29.62,29.59,29.51,29.39,29.35,26.15,23.65,22.70,16.96,14.15.

[0062] Example 10: Synthesis of the compound represented by formula IV-5

[0063]

[0064] Weigh N-(5-iodoquinolin-8-yl)-2-vinyl-4-pentenamide (0.076 g, 0.20 mmol of the compound shown in formula (5)), CuOTf (0.004 g, 0.04 mmol) and dissolve them in 2 mL of tetrahydrofuran, and add dodecanoyl peroxide (0.159 g, 0.40 mmol). Heat the mixture to 80°C for reaction, and track the reaction by TLC until the reaction is completely completed. After the reaction is completed, the crude product is purified by silica gel column chromatography (petroleum ether: ethyl acetate = 20:1) to obtain compound IV-5, with an isolation yield of 56%.

[0065] The above IV-5 was characterized by NMR, and the results were:

[0066] 1 H NMR(400MHz,Chloroform-d)δ8.80(dd,J=4.1,1.7Hz,1H),8.34(dd,J=8.6,1.6Hz,1H),8.16–7.98( m,2H),7.46(dd,J=8.6,4.1Hz,1H),5.92(ddt,J=17.0,10.1,7.0Hz,1H),5.31–5.07(m,2H),4.86(dt ,J=9.3,2.9Hz,1H),3.04(dddd,J=9.1,5.5,2.3Hz,1H),2.78–2.50(m,2H),1.93(dddd,J=12.9,9.4, 6.3, 3.3Hz, 1H), 1.48 (dtd, J=13.9, 9.2, 4.8Hz, 1H), 1.22 (d, J=14.9Hz, 20H), 0.87 (t, J=6.8Hz, 3H).

[0067] 13C NMR(101MHz,Chloroform-d)δ169.00,149.38,140.35,137.69,134.93,122.86,122.57,117.26,9 1.82,63.11,55.88,33.41,33.26,31.92,29.66,29.63,29.51,29.39,29.35,25.17,22.70,14.14.

[0068] Example 11: Synthesis of the compound represented by formula IV-6

[0069]

[0070] 2-(Cyclopropylmethyl)-N-(5-iodoquinolin-8-yl)-3-buteneamide (0.078 g, 0.20 mmol of the compound shown in formula (6)) and CuOTf (0.004 g, 0.04 mmol) were weighed and dissolved in 2 mL of tetrahydrofuran, and dodecanoyl peroxide (0.159 g, 0.40 mmol) was added. The mixture was heated to 80°C for reaction, and the reaction was tracked by TLC until the reaction was completely completed. After the reaction was completed, the crude product was purified by silica gel column chromatography (petroleum ether: ethyl acetate = 20:1) to obtain compound IV-6, and the separation yield was 30%.

[0071] The above IV-6 was characterized by NMR, and the results were:

[0072] 1 H NMR(400MHz,Chloroform-d)δ8.80(dd,J=4.1,1.7Hz,1H),8.34(dd,J=8.6,1.6Hz,1H),8. 06(q,J=8.2Hz,2H),7.47(dd,J=8.6,4.1Hz,1H),4.92(dt,J=9.3,2.9Hz,1H),3.07(ddd,J =8.5,6.4,2.3Hz,1H),1.96(dddd,J=12.2,8.9,6.3,3.0Hz,1H),1.82–1.74(m,2H),1.54– 1.44(m,1H),1.39–1.17(m,20H),0.95–0.82(m,4H),0.60–0.45(m,2H),0.26–0.09(m,2H).

[0073] 13C NMR(101MHz,Chloroform-d)δ169.72,149.33,140.34,137.71,130.50,122.83,122.55,63.48,56.95, 34.07,33.55,31.92,29.66,29.63,29.51,29.48,29.44,29.35,25.25,22.70,14.13,9.27,5.14,4.49.

[0074] Example 12: Synthesis of the compound represented by formula IV-7

[0075]

[0076] 2-Benzyl-N-(5-iodoquinolin-8-yl)-3-buteneamide (0.086 g, 0.20 mmol of the compound shown in formula (7)) and CuOTf (0.004 g, 0.04 mmol) were weighed and dissolved in 2 mL of tetrahydrofuran, and dodecanoyl peroxide (0.159 g, 0.40 mmol) was added. The mixture was heated to 80°C for reaction, and the reaction was tracked by TLC until the reaction was completely completed. After the reaction was completed, the crude product was purified by silica gel column chromatography (petroleum ether: ethyl acetate = 20:1) to obtain compound IV-7, and the separation yield was 52%.

[0077] The above IV-7 was characterized by NMR, and the results were:

[0078] 1 H NMR(400MHz,Chloroform-d)δ8.79(dd,J=4.1,1.6Hz,1H),8.34(dd,J=8.6,1.6Hz,1H),8.13–8.0 0(m,2H),7.46(dd,J=8.6,4.1Hz,1H),7.33(d,J=4.4Hz,4H),7.26–7.21(m,1H),4.90(dt,J=9.5, 2.8Hz,1H),3.36(dd,J=13.8,5.0Hz,1H),3.22(ddd,J=10.1,5.0,2.3Hz,1H),3.02(dd,J=13.8,1 0.2Hz, 1H), 1.81 (dddd, J=13.0, 9.7, 6.6, 3.2Hz, 1H), 1.43–0.95 (m, 20H), 0.88 (t, J=6.9Hz, 4H).

[0079] 13C NMR(101MHz,Chloroform-d)δ168.97,149.40,140.35,139.14,137.69,134.72,130.51,128.94,128.61,126.56,122. 88,122.66,91.95,63.50,58.29,35.39,33.28,31.94,29.67,29.65,29.62,29.37,29.32,29.24,24.75,22.72,14.15.

[0080] Example 13: Synthesis of the compound represented by formula IV-8

[0081]

[0082] Weigh N-(5-iodoquinolin-8-yl)-2-(4-methylbenzyl)-3-buteneamide (0.088 g, 0.20 mmol of the compound shown in formula (8)), CuOTf (0.004 g, 0.04 mmol) and dissolve them in 2 mL of tetrahydrofuran, and add dodecanoyl peroxide (0.159 g, 0.40 mmol). Heat the mixture to 80°C for reaction, and track the reaction by TLC until the reaction is completely completed. After the reaction is completed, the crude product is purified by silica gel column chromatography (petroleum ether: ethyl acetate = 20:1) to obtain compound IV-8, with an isolation yield of 51%.

[0083] The above IV-8 was characterized by NMR, and the results were:

[0084] 1 H NMR(400MHz,Chloroform-d)δ8.89–8.70(m,1H),8.42–8.25(m,1H),8.18–7.97(m,2H ),7.46(dd,J=8.4,4.0Hz,1H),7.27–7.10(m,4H),4.89(dt,J=9.3,2.8Hz,1H),3.32( dd,J=13.8,4.9Hz,1H),3.26–3.12(m,1H),2.98(dd,J=13.6,9.9Hz,1H),2.33(s,3H) ,1.81(dtd,J=12.8,8.0,6.5,3.3Hz,1H),1.45–0.91(m,21H),0.88(d,J=7.2Hz,3H).

[0085] 13C NMR(101MHz,Chloroform-d)δ169.08,149.37,140.33,137.69,136.02,134.79,130.50,129.26,128.80,12 2.86,122.62,63.51,58.38,34.96,33.31,31.94,29.68,29.40,29.37,29.26,24.78,22.72,21.07,14.16.

[0086] The above-described embodiments are only preferred embodiments for fully illustrating the present invention, and the protection scope of the present invention is not limited thereto. Equivalent substitutions or changes made by those skilled in the art based on the present invention are within the protection scope of the present invention. The protection scope of the present invention shall be subject to the claims.

Claims

1. A 4-lauryl-β-lactam derivative, characterized in that: The structural formula of the 4-lauryl-β-lactam derivative is shown in IV: Among them, R 1 , R 2 Independently selected from one of hydrogen, C1-C6 saturated or unsaturated alkyl, and substituted or unsubstituted benzyl.

2. The 4-lauryl-β-lactam derivative according to claim 1, characterized in that R 1 , R 2 are independently selected from hydrogen, methyl, ethyl, allyl, cyclopropylmethyl, benzyl or p-methylbenzyl.

3. The 4-lauryl-β-lactam derivative according to claim 1, characterized in that The 4-lauryl-β-lactam derivative is selected from the structures shown in formulas IV-1 to IV-8:

4. A method for preparing the 4-lauryl-β-lactam derivative according to any one of claims 1 to 3, characterized in that: reacting the compound represented by formula (I) and the compound represented by formula (II) in the presence of a metal salt catalyst and a solvent to obtain the 4-lauryl-β-lactam derivative; The structures of the above formula (I) and formula (II) are shown below: Among them, R 1 , R 2 Independently selected from one of hydrogen, C1-C6 saturated or unsaturated alkyl, and substituted or unsubstituted benzyl.

5. The preparation method according to claim 4, characterized in that: The compound represented by formula (I) is N-(5-iodoquinolin-8-yl)-3-butenamide, N-(5-iodoquinolin-8-yl)-2-methyl-3-butenamide, 2-ethyl-N-(5-iodoquinolin-8-yl)-3-butenamide, N-(5-iodoquinolin-8-yl)-2,2-dimethyl-3-butenamide, N-(5-iodoquinolin-8-yl)-2-vinyl-4-pentenamide, 2-(cyclopropylmethyl)-N-(5-iodoquinolin-8-yl)-3-butenamide, 2-benzyl-N-(5-iodoquinolin-8-yl)-3-butenamide or N-(5-iodoquinolin-8-yl)-2-(4-methylbenzyl)-3-butenamide.

6. The preparation method according to claim 4, characterized in that: The metal salt catalyst is selected from one or more of cuprous bromide, cuprous iodide, cupric acetate, cuprous chloride, tetraacetonitrile copper hexafluorophosphate, and cuprous trifluoromethanesulfonate.

7. The preparation method according to claim 4, characterized in that: The solvent is selected from one or more of acetonitrile, toluene, dichloromethane, 1,2-dichloroethane, 1,4-dioxane, methyl tert-butyl ether, and tetrahydrofuran.

8. The preparation method according to claim 4, characterized in that: The molar ratio of the compound represented by formula (I), the compound represented by formula (II) and the metal salt catalyst is 1:1-3:0.02-0.

7.

9. The preparation method according to claim 4, characterized in that: The ratio of the molar amount of the compound represented by the formula (I) to the volume of the solvent is 1 mmol: (5-30) mL.

10. The preparation method according to claim 4, characterized in that: The reaction temperature is 60-100°C.

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