Multi-channel multi-joint-inspection parallel pretreatment device and POCT (Point of Care Testing) full-automatic chemiluminescence equipment

Abstract

The multi-channel multi-joint-inspection parallel pretreatment device comprises a portal frame, wherein a first driving element is arranged at the top of the portal frame; the sample extraction mechanism is arranged on the portal frame and comprises a first mounting frame, a second driving element and an extraction assembly, the second driving element can drive the first mounting frame to ascend and descend, and the second driving element can drive the extraction assembly to ascend and descend so as to suck and spit samples; the sample pretreatment mechanism is arranged on the portal frame and comprises a second mounting frame, a third driving element and a pretreatment assembly, and the first driving element can drive the second mounting frame to ascend and descend; the pretreatment assembly comprises at least two rows of magnetic bars arranged side by side in the width direction of the pretreatment assembly, each row of magnetic bars comprises at least two magnetic bars, and the third driving element can drive the pretreatment assembly to ascend and descend so as to transfer the magnetic particles through the at least two rows of magnetic bars. The invention also provides the POCT full-automatic chemiluminescence equipment. According to the invention, the pretreatment assembly comprises at least two rows of magnetic bars for transferring magnetic particles, so that multi-joint detection can be realized while the size of the equipment is controlled.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical equipment, and in particular relates to a multi-channel multi-joint detection parallel pre-processing device and a POCT fully automatic chemiluminescence device. Background Art

[0002] As a rapidly developing non-radioactive immunoassay technology, chemiluminescent immunoassay technology has become one of the important directions of immunological detection. Its principle is to use chemiluminescent signals to directly measure immune reactions. Chemiluminescent equipment using chemiluminescent immunoassay technology has the advantages of high sensitivity, good repeatability, high accuracy, good specificity and wide linear range.

[0003] POCT (Point-Of-Care Testing) is a testing method that conducts clinical testing immediately at the sampling site, eliminating the complex processing procedures of specimens in laboratory tests, and quickly obtaining test results. It has the characteristics of instrument programming, simple operation, and fast reporting of results.

[0004] At present, POCT fully automatic chemiluminescence equipment has been manufactured by applying chemiluminescence immunoassay technology to POCT products. The POCT fully automatic chemiluminescence equipment generally includes a reaction chamber module and a multi-channel parallel pre-processing module. The reaction chamber module is loaded with reagent strips containing various reagents, and the reagent strips are moved to the multi-channel parallel pre-processing module for corresponding processing.

[0005] However, the current multi-channel parallel pre-processing module can only transfer magnetic particles in one well on the reagent strip at a time. If magnetic particles in multiple wells need to be transferred, multiple operations are required, which increases the risk of cross-interference and prolongs the transfer time of the magnetic particles. In addition, since it takes a long time to transfer magnetic particles multiple times, the analysis efficiency of the equipment is affected. Summary of the invention

[0006] An embodiment of the present invention provides a multi-channel multi-inspection parallel pre-processing device, which aims to solve the technical problem that the existing multi-channel parallel pre-processing module can only transfer magnetic particles in one hole at a time, and multiple operations are required to transfer magnetic particles in multiple holes, resulting in an increased risk of cross-interference, prolonged transfer time of magnetic particles and detection and analysis time of the equipment.

[0007] The embodiment of the present invention is implemented as follows: a multi-channel multi-joint detection parallel pre-processing device, comprising:

[0008] A gantry, wherein a first driving element is provided on the top of the gantry;

[0009] a sample extraction mechanism disposed on the gantry, the sample extraction mechanism comprising a first mounting frame disposed on the gantry and drivingly connected to the first driving element, a second driving element disposed on the first mounting frame, and an extraction component disposed on the first mounting frame and drivingly connected to the second driving element, the second driving element being capable of driving the first mounting frame to rise and fall, and the second driving element being capable of driving the extraction component to rise and fall to aspirate and discharge samples; and

[0010] A sample pre-processing mechanism disposed on the gantry, the sample pre-processing mechanism comprising a second mounting frame disposed on the gantry and drivingly connected to the first driving element, a third driving element disposed on the second mounting frame, and a pre-processing assembly disposed on the second mounting frame and drivingly connected to the third driving element, wherein the first driving element can drive the second mounting frame to rise and fall;

[0011] The pre-processing component comprises at least two rows of magnetic bars arranged side by side along the width direction of the pre-processing component, each row has at least two magnetic bars, and the third driving element can drive the pre-processing component to rise and fall to transfer magnetic particles through at least two rows of magnetic bars.

[0012] Furthermore, the pre-processing component includes:

[0013] A magnetic bar device is arranged on the second mounting frame, wherein a plurality of movable through holes are formed in the magnetic bar device, and a plurality of first loading heads for loading disposable magnetic separation sleeves are arranged at the bottom of the magnetic bar device, and the plurality of first loading heads are connected to the plurality of movable through holes in a one-to-one correspondence;

[0014] a first push plate disposed above the magnetic bar device, the first push plate being drivingly connected to the third driving element; and

[0015] There are multiple connecting rods arranged on the first pushing plate, and at least two rows of magnetic bars are arranged one by one on the free ends of the multiple connecting rods. The third driving element can drive the first pushing plate to drive the magnetic bars to rise and fall in the corresponding active through holes so as to be separated from the first loading head or pass through the first loading head.

[0016] Furthermore, the magnetic bars are arranged in multiple rows and are evenly spaced along the width direction of the first push plate; each row has multiple magnetic bars and the multiple magnetic bars in each row are evenly spaced along the length direction of the first push plate.

[0017] Furthermore, the sample pre-processing mechanism also includes:

[0018] a first slide rail disposed on the second mounting frame, the first slide rail being distributed along a height direction of the second mounting frame; and

[0019] A first sliding block is disposed on the first pushing plate, and the first sliding block is slidably connected to the first sliding rail.

[0020] Furthermore, the extraction component comprises:

[0021] An injection device arranged on the first mounting frame, wherein a plurality of injection cavities are formed in the injection device, a plurality of second loading heads for loading tip heads are arranged at the bottom of the injection device, and the plurality of second loading heads are connected to the plurality of injection cavities in a one-to-one correspondence;

[0022] a second push plate disposed above the injection device, the second push plate being drivingly connected to the second driving element; and

[0023] A plurality of piston rods are arranged on the second push plate, and the piston rods are movably and sealedly connected to the syringe cavity. The second driving element can drive the second push plate to drive the piston rods to rise and fall in the syringe cavity to perform a suction and exhalation action.

[0024] Furthermore, the sample extraction mechanism also includes:

[0025] A push rod that can be lifted and lowered and passes through the injection device, wherein the top end of the push rod is spaced apart from the second push plate;

[0026] an elastic element sleeved on the push rod in the injection device, wherein the elastic element is stretched or compressed simultaneously when the push rod is lifted or lowered relative to the injection device; and

[0027] A separation plate is arranged at the bottom of the injection device, the second loading head passes through the separation plate, the bottom end of the push rod is connected to the separation plate, and the push rod can drive the separation plate to rise and fall relative to the second loading head.

[0028] Furthermore, the plurality of syringe cavities are evenly spaced apart along the length direction of the injection device, the plurality of second loading heads are evenly spaced apart along the length direction of the injection device, and the plurality of piston rods are evenly spaced apart along the length direction of the second push plate.

[0029] Furthermore, the sample extraction mechanism also includes:

[0030] a second slide rail disposed between the injection device and the second push plate; and

[0031] A second sliding block is arranged on the second pushing plate, and the second sliding block is slidably connected to the second sliding rail.

[0032] Furthermore, the sample extraction mechanism is opposite to the sample pre-processing mechanism, and the sample extraction mechanism is located in front of the sample pre-processing mechanism, and the first driving element, the second driving element and the third driving element are linearly arranged on the top of the gantry.

[0033] Furthermore, the gantry is provided with an activity space, the transmission shaft of the first driving element passes through the activity space, a transmission plate is sleeved on the transmission shaft, and the transmission plate can be raised and lowered in the activity space when the transmission shaft moves;

[0034] A first connection portion is provided on a side of the first mounting frame facing the gantry, and a second connection portion is provided on a side of the second mounting frame facing the gantry. Both the first connection portion and the second connection portion are connected to the transmission plate.

[0035] Furthermore, a third slider is provided on a side of the first mounting frame facing the gantry, a third slide rail is provided on a side of the gantry facing the first mounting frame, the third slide rail extends along a height direction of the gantry, and the third slider is slidably connected to the third slide rail;

[0036] A fourth slider is disposed on a side of the second mounting frame facing the gantry, a fourth slide rail is disposed on a side of the gantry facing the second mounting frame, the fourth slide rail extends along a height direction of the gantry, and the fourth slider is slidably connected to the fourth slide rail.

[0037] Furthermore, a first sensing member is provided on one side of the top of the first mounting frame, and a first detector is provided on one side of the top of the gantry frame, and the first sensing member can generate or disconnect induction with the first detector as the first mounting frame rises and falls;

[0038] A second sensing member is provided on one side of the top of the second mounting frame, and a second detector is provided on one side of the top of the gantry frame. The second sensing member can generate or disconnect induction with the second detector as the second mounting frame rises and falls.

[0039] The embodiment of the present invention also provides a multi-test POCT fully automatic chemiluminescence device, including:

[0040] Install the frame;

[0041] A reaction chamber device disposed on the mounting frame, the reaction chamber device being reciprocatable along the length direction of the mounting frame, the reaction chamber device being used to load a reagent strip;

[0042] a PMT device disposed at the rear end of the mounting frame and located above the reaction chamber device, the reaction chamber device being used to move the reagent strip to the PMT device, the PMT device being used to detect the luminescence value of the detection position of the reagent strip; and

[0043] According to any of the above-mentioned multi-channel multi-joint detection parallel pre-processing devices, the multi-channel multi-joint detection parallel pre-processing device is used to aspirate and discharge samples and transfer magnetic particles from the reagents in the reagent strip.

[0044] In the multi-channel multi-joint detection parallel pre-processing device of the embodiment of the present invention, the pre-processing component includes at least two rows of magnetic bars for transferring magnetic particles and each row of magnetic bars has at least two magnetic bars, that is, the pre-processing component can simultaneously transfer the magnetic particles in at least two reagent wells on a single reagent strip, and transfer the magnetic particles in at least two reagent strips arranged in parallel, thereby realizing the detection of at least two items, and realizing multi-joint detection while realizing multi-channel parallel processing, which can reduce the risk of cross-infection, shorten the time and equipment volume for transferring magnetic particles, and ensure the analysis efficiency of the equipment for multiple items. BRIEF DESCRIPTION OF THE DRAWINGS

[0045] Figure 1 is a three-dimensional schematic diagram of a POCT fully automatic chemiluminescence device according to an embodiment of the present invention;

[0046] Figure 2 It is a three-dimensional schematic diagram of a POCT fully automatic chemiluminescence device according to a part of an embodiment of the present invention;

[0047] Figure 3 It is a three-dimensional schematic diagram of a multi-channel multi-joint inspection parallel pre-processing device according to an embodiment of the present invention;

[0048] Figure 4 It is a three-dimensional disassembly schematic diagram of a multi-channel multi-joint inspection parallel pre-processing device according to an embodiment of the present invention;

[0049] Figure 5 2 is a schematic diagram of the structure of a multi-channel multi-joint inspection parallel pre-processing device according to an embodiment of the present invention;

[0050] Figure 6 is a three-dimensional schematic diagram of a gantry according to an embodiment of the present invention;

[0051] Figure 7 is another three-dimensional schematic diagram of the gantry according to an embodiment of the present invention;

[0052] Figure 8 is a three-dimensional schematic diagram of a sample extraction mechanism according to an embodiment of the present invention;

[0053] Fig. 9 It is a three-dimensional schematic diagram of a sample pre-processing mechanism according to an embodiment of the present invention.

[0054] Description of main component symbols:

[0055] Multi-channel multi-joint detection parallel pre-processing device-10; gantry-11; activity space-111; transmission plate-112; third slide rail-113; fourth slide rail-114; first detector-115; first driving element-12; sample extraction mechanism-13; first mounting frame-131; second driving element-132; extraction assembly-133; injection device-1331; second loading head-1332; second push plate-1333; piston rod-1334; push rod-1335; elastic element-1336; separation plate-1337; second slide rail- 134; second slider-135; third slider-136; first sensor-137; sample pre-processing mechanism-14; second mounting frame-141; third driving element-142; pre-processing assembly-143; magnetic rod device-1431; first loading head-1432; first push plate-1433; connecting rod-1434; magnetic rod-1435; first slide rail-144; first slider-145; fourth slider-146; mounting frame-20; reaction chamber device-30; PMT device-40; POCT fully automatic chemiluminescence equipment-100. DETAILED DESCRIPTION

[0056] In order to make the purpose, technical scheme and advantages of the present invention clearer, the present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. Examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements with the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and should not be construed as limiting the present invention. In addition, it should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0057] In the description of the present invention, it is necessary to understand that the orientation or positional relationship indicated in the description of the direction and positional relationship is based on the orientation or positional relationship shown in the accompanying drawings, which is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0058] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0059] The disclosure below provides many different embodiments or examples to realize different structures of the present invention. In order to simplify the disclosure of the present invention, the parts and settings of specific examples are described below. Of course, they are only examples, and the purpose is not to limit the present invention. In addition, the present invention can repeat reference numbers and / or reference letters in different examples, and this repetition is for the purpose of simplification and clarity, which itself does not indicate the relationship between the various embodiments and / or settings discussed. In addition, the examples of various specific processes and materials provided by the present invention, but those of ordinary skill in the art can be aware of the application of other processes and / or the use of other materials.

[0060] See also Figures 1 to 9 The multi-channel multi-joint inspection parallel pre-processing device 10 of the embodiment of the present invention comprises:

[0061] A gantry 11, a first driving element 12 is provided on the top of the gantry 11;

[0062] A sample extraction mechanism 13 is disposed on the gantry 11, the sample extraction mechanism 13 comprises a first mounting frame 131 disposed on the gantry 11 and drivingly connected to the first driving element 13, a second driving element 132 disposed on the first mounting frame 131, and an extraction component 133 disposed on the first mounting frame 131 and drivingly connected to the second driving element 132, the second driving element 132 can drive the first mounting frame 131 to rise and fall, and the second driving element 132 can drive the extraction component 133 to rise and fall to suck and discharge samples; and

[0063] The sample pre-processing mechanism 14 is arranged on the gantry 11, and the sample pre-processing mechanism 14 includes a second mounting frame 141 arranged on the gantry 11 and drivingly connected to the first driving element 12, a third driving element 142 arranged on the second mounting frame 141, and a pre-processing component 143 arranged on the second mounting frame 141 and drivingly connected to the third driving element 142. The first driving element 13 can drive the second mounting frame 141 to rise and fall;

[0064] The pre-processing component 143 includes at least two rows of magnetic bars 1435 arranged side by side along the width direction of the pre-processing component 143 , with at least two magnetic bars 1435 in each row. The third driving element 142 can drive the pre-processing component 143 to rise and fall to transfer magnetic particles through at least two rows of magnetic bars 1435 .

[0065] In the multi-channel multi-joint inspection parallel pre-processing device 10 of an embodiment of the present invention, the pre-processing component 143 includes at least two rows of magnetic bars 1435 for transferring magnetic particles, and there are at least two magnetic bars 1435 in each row, that is, the pre-processing component 143 can simultaneously transfer the magnetic particles in at least two reagent wells on a single reagent strip, and transfer the magnetic particles in at least two reagent strips arranged in parallel, thereby realizing the detection of at least two items, realizing multi-joint inspection while realizing multi-channel parallel processing, and realizing the multi-channel multi-joint inspection function of the multi-channel multi-joint inspection parallel pre-processing device 10, which can reduce the risk of cross-infection, control the time and equipment volume for transferring magnetic particles, and ensure the equipment's analysis efficiency for multiple items.

[0066] Specifically, the gantry 11 spans across the width direction of the POCT fully automatic chemiluminescence device 100 , so that the sample extraction mechanism 13 and the sample pre-processing mechanism 14 can span above the reaction chamber device 30 to achieve multi-channel parallel pre-processing.

[0067] In the embodiment of the present invention, the sample extraction mechanism 13 is used to combine with the tip head on the reagent strip to transfer the sample or reagent and break the sealing film of each hole, and the sample pretreatment mechanism 14 is used to combine with the disposable magnetic separation sleeve on the reagent strip to adsorb, mix, clean and transfer magnetic particles.

[0068] The sample pretreatment mechanism 14 and the sample extraction mechanism 13 are located on opposite sides of the gantry 11, which can avoid the problem that the sample pretreatment mechanism 14 and the sample extraction mechanism 13 are arranged on the same side of the gantry 11, resulting in crowded space and heavy load on one side of the gantry 11, inconvenient operation and unstable structure of the gantry 11. The sample extraction mechanism 13 and the sample pretreatment mechanism 14 can also correspond to reagent holes with different functions on the reagent strip respectively. For example, the front section of the reagent strip requires more participation of the sample extraction mechanism 13, while the rear section requires more participation of the sample pretreatment mechanism 14, which can further improve the pretreatment speed of the multi-channel multi-test parallel pretreatment device 10 on the reagent strip.

[0069] When the reagent strip is used for multiple detection items and the length of the reagent strip becomes longer, the reaction chamber device does not need to move the reagent strip for a long distance but only needs to move the reagent strip to the corresponding position. The reagent strip can be processed separately by the relatively separated sample extraction mechanism 13 and the sample pre-processing mechanism 14, such as the sample can be aspirated and the magnetic particles can be transferred separately, thereby shortening the time required for transferring the reagent strip in the reaction chamber device.

[0070] Taking the reagent strip for multiplex detection as an example, from one end of the reagent strip to the other end, there may be sample holes, tip holes, multiple disposable magnetic separation holes, multiple magnetic labeling ligand holes, multiple enzyme labeling ligand holes, multiple cleaning liquid holes and multiple substrate reading holes (detection positions) in sequence, and the number of disposable magnetic separation holes, magnetic labeling ligand holes, enzyme labeling ligand holes and substrate reading holes is the same. Among them, ligands include but are not limited to haptens, antigens, monoclonal antibodies, polyclonal antibodies and nucleic acid ligands.

[0071] The sample hole is used to add blood samples, the tip hole is provided with a tip head, the disposable magnetic separation sleeve hole is provided with a disposable magnetic separation sleeve, the magnetic labeled ligand hole contains the magnetic labeled ligand, the enzyme labeled ligand hole contains the enzyme labeled ligand, the cleaning liquid hole contains the cleaning liquid, and the substrate reading hole contains the substrate reading.

[0072] Specifically, the tip is a hollow structure with a sharp end and a perforation on the end, so that the tip can be used to transfer samples or reagents, and can also be used to break the sealing film on each hole. The disposable magnetic separation sleeve is also a hollow structure, which can be used to adsorb, mix, clean and transfer magnetic particles. The cleaning liquid hole can be used to clean the magnetic particles. The substrate reading hole can be used to perform a chemiluminescent reaction and read the luminescence value.

[0073] In one embodiment, the first driving element 12 may be a screw motor. The screw motor has high motion accuracy and is more accurate and stable in position adjustment. The first driving element 12 disposed on the top of the gantry 11 drives the sample extraction mechanism 13 and the sample pre-processing mechanism 14 to rise and fall on the gantry 11, so that the sample extraction mechanism 13 and the sample pre-processing mechanism 14 can be moved close to or away from the reagent strip smoothly and accurately.

[0074] In this embodiment, the first driving element 12 can drive the first mounting frame 131 to rise and fall, thereby driving the sample extraction mechanism 13 to rise and fall, so as to perform corresponding processing such as aspirating and spitting samples on the reagent strip. The first mounting frame 131 can be substantially "L"-shaped, and includes a two-part structure, such as a horizontal extension plate and a vertical extension plate. The second driving element 132 can be arranged on the horizontal extension plate to ensure a stable setting, thereby providing stable power for the lifting and lowering of the extraction component 133.

[0075] The extraction component 133 is arranged on the vertical extension plate, and the second driving element 132 can be a screw motor. Its transmission shaft (i.e., the transmission screw) passes through the horizontal extension plate and extends downward to be transmission-connected with the extraction component 133. The transmission connection between the two can be a threaded connection, which can not only ensure the connection stability between the two, but also the second driving element 132 can make the extraction component 133 move smoothly and accurately in the vertical direction through threaded driving, so as to smoothly and accurately aspirate the sample after contacting with the sample.

[0076] In this embodiment, the first driving element 12 can drive the second mounting frame 141 to rise and fall, thereby driving the sample pre-processing mechanism 14 to rise and fall, so as to perform corresponding treatments such as transferring magnetic particles on the reagent strip. The second mounting frame 141 can be substantially "L"-shaped, and includes two parts, such as a horizontal extension plate and a vertical extension plate. The third driving element 142 can be arranged on the horizontal extension plate to ensure a stable setting, thereby providing stable power for the rise and fall of the pre-processing component 143.

[0077] The pre-processing component 143 is arranged on the vertical extension plate, and the third driving element 142 can be a screw motor. Its transmission shaft (i.e., the transmission screw) passes through the horizontal extension plate and extends downward to be connected to the pre-processing component 143. The transmission connection between the two can be a threaded connection, which can not only ensure the stability of the connection between the two, but also the third driving element 142 can drive the pre-processing component 143 in the vertical direction smoothly and accurately, so as to smoothly and accurately adsorb the magnetic particles in the reagent strip and then transfer them.

[0078] The pre-processing component 143 includes at least two rows of magnetic bars 1435 arranged side by side along the width direction of the pre-processing component 143, that is, the pre-processing component 143 can transfer magnetic particles in at least two reagent holes on a single reagent strip to achieve detection of at least two items, that is, to achieve multi-joint detection. There are at least two magnetic bars 1435 in each row, that is, the pre-processing component 143 can simultaneously transfer magnetic particles in at least two reagent strips arranged in parallel, to achieve multi-channel parallel processing.

[0079] Correspondingly, the reagent strip corresponding to the multi-channel multi-test parallel pre-processing device 10 of the embodiment of the present invention is a multi-test reagent strip, in which disposable magnetic separation sleeves, reagent wells containing magnetic particles, and detection positions containing substrate readings are provided, which are equal to the number of rows of magnetic rods 1435. Exemplarily, if there are two rows of magnetic rods, the number of disposable magnetic separation sleeves, reagent wells containing magnetic particles, and detection positions containing substrate readings on the reagent strip are all two.

[0080] In the embodiment of the present invention, the sample extraction mechanism 13 is opposite to the sample pre-processing mechanism 14 on the gantry 11, and the sample extraction mechanism 13 is located in front of the sample pre-processing mechanism 14, and the first driving element 12, the second driving element 132 and the third driving element 142 are arranged linearly on the top of the gantry 11, so that the top structure distribution of the multi-channel multi-joint inspection parallel pre-processing device 10 is regular, and the three driving elements are basically concentrated in the middle position of the gantry 11 when exerting force, so that the gantry 11 is evenly stressed and not prone to shaking or deviation.

[0081] See also Fig. 9 , further, the pre-processing component 14 includes:

[0082] A magnetic bar device 1431 is arranged on the second mounting frame 141, wherein a plurality of movable through holes are formed in the magnetic bar device 1431, and a plurality of first loading heads 1432 for loading disposable magnetic separation sleeves are arranged at the bottom of the magnetic bar device 1431, wherein the plurality of first loading heads 1432 are connected to the plurality of movable through holes in a one-to-one correspondence;

[0083] A first push plate 1433 disposed above the magnetic bar device 1431, the first push plate 1433 is drivingly connected to the third driving element 142; and

[0084] A plurality of connecting rods 1434 are arranged on the first pushing plate 1433, and at least two rows of magnetic rods 1435 are arranged one by one on the free ends of the plurality of connecting rods 1434. The third driving element 142 can drive the first pushing plate 1433 to drive the magnetic rods 1435 to rise and fall in the corresponding movable through holes so as to be separated from the first loading head 1432 or pass through the first loading head 1432.

[0085] Specifically, the magnetic rod components are distributed along the width direction of the second mounting frame 141, so that the active through holes therein can be distributed in the width direction of the pre-processing component 143 to correspond to the location of the reagent strip. When the disposable magnetic separation sleeve needs to be loaded, the first driving element 12 drives the second mounting frame 141 to descend to the second loading head 1432 to contact and load the disposable magnetic separation sleeve, and the two are interference fit, thereby ensuring the stability of the disposable magnetic separation sleeve loaded on the second loading head 1432 and facilitating separation.

[0086] The second loading head 1432 is connected to the movable through hole, so that the movable through hole is connected to the disposable magnetic separation sleeve. When the third driving element 142 drives the connecting rod 1434 to drive the magnetic rod 1435 to pass through the second loading head 1432 to extend into the disposable magnetic separation sleeve, the magnetic particles can be adsorbed by the disposable magnetic separation sleeve. When the disposable magnetic separation sleeve needs to be separated, the third driving element 142 is controlled to drive the magnetic rod 1435 to drop to abut against the bottom end of the disposable magnetic separation sleeve, and the disposable magnetic separation sleeve can be withdrawn from the second loading head 1432. When the third driving element 142 drives the connecting rod 1434 to drive the magnetic rod 1435 to separate from the second loading head 1432 and separate from the disposable magnetic separation sleeve, the magnetic particles can be separated from the disposable magnetic separation sleeve to achieve transfer.

[0087] In addition, based on the transfer of magnetic particles, the pre-treatment component 143 can also be used to transfer the magnetic particles to the reagent for reaction mixing, or to separate the magnetic particles in the reaction solution into the cleaning solution, or to transfer the magnetic particles to the substrate reading for reaction and complete luminescence detection.

[0088] The transmission shaft of the third driving element 142 extends downward through the top of the second mounting frame 141 and the second push plate 1433. A fixing piece threadedly connected to the transmission shaft can be set on the transmission shaft, and the second push plate 1433 can be fixed on the fixing piece. When the transmission shaft of the third driving element 142 moves, the second push plate 1433 can be driven to rise and fall through the fixing piece to realize the lifting and lowering of the magnetic rod 1435.

[0089] Alternatively, a screw hole may be provided on the second push plate 1433, and a thread may be provided on the transmission shaft of the third driving element 142, so that the transmission shaft is threadedly connected to the second push plate 1433. This can ensure the stability of the connection between the two, and the third driving element 142 can also drive the second push plate 1433 to rise and fall by threaded driving.

[0090] See also Figure 5 and Fig. 9 Furthermore, the magnetic bars 1435 are arranged in multiple rows, and the multiple rows of magnetic bars 1435 are evenly spaced along the width direction of the first push plate 1433, and the number of rows of magnetic bars 1435 is equal to the number of substrate reading holes on the reagent strip and the number of reagent holes containing magnetic particles, so as to realize the detection of multiple items, that is, to realize multi-joint detection. There are multiple magnetic bars 1435 in each row, and the multiple magnetic bars 1435 in each row are evenly spaced along the length direction of the first push plate 1433, and the number of magnetic bars 1435 in each row is equal to the number of reagent strips, so as to realize multi-channel parallel processing of multiple reagent strips.

[0091] In the embodiment of the present invention, there are three rows of magnetic rods 1435, that is, the sample pretreatment mechanism 14 can simultaneously transfer the magnetic particles in the three reagent holes of the reagent strip, and can realize the detection of three items. The space occupied by the three rows of magnetic rods 1435 is not large, and three tests can be realized, and multiple tests can be realized while controlling the volume of the POCT fully automatic chemiluminescence device 100.

[0092] Of course, in other embodiments, the magnetic bars 1435 can also be arranged in 2 rows, 4 rows or even more rows to detect different numbers of items.

[0093] Exemplarily, the process of transferring magnetic particles by the sample pre-processing mechanism 14 is roughly as follows:

[0094] After the sample is injected into the corresponding reagent hole of the reagent strip, the reaction chamber device 30 drives the reagent strip to move so that the sample pretreatment mechanism 14 is located directly above the disposable magnetic separation sleeve. At this time, the first driving element 12 drives the second mounting frame 141 to descend a certain height until the disposable magnetic separation sleeve is loaded on the second loading head 1432. The first driving element 12 drives the second mounting frame 141 to rise, and the disposable magnetic separation sleeve is driven by the second loading head 1432 to rise to a certain height.

[0095] Afterwards, the reaction chamber device 30 moves to the top of the corresponding hole of the reagent strip when the sample pretreatment mechanism 14 loaded with the disposable magnetic separation sleeve moves. The third driving element 142 drives the magnetic rod 1435 to descend until the magnetic rod 1435 contacts the bottom of the disposable magnetic separation sleeve. At this time, the first driving element 12 drives the second mounting bracket 141 to descend to a certain height, so that the disposable magnetic separation sleeve extends into the liquid containing magnetic particles until the disposable magnetic separation sleeve contacts the bottom of the magnetically labeled ligand hole, so that the magnetic particles are gradually adsorbed to the end of the disposable magnetic separation sleeve. The magnetic particles can be fully adsorbed by slowly lifting and lowering the sleeve multiple times.

[0096] After the adsorption of the magnetic particles is completed, the first driving element 12 is controlled to drive the second mounting frame 141 to rise. At this time, all the magnetic particles are adsorbed on the outer wall of the disposable magnetic separation sleeve. The reaction chamber device 30 is controlled to move until the disposable magnetic separation sleeve is located above the cleaning liquid. The first driving element 12 drives the second mounting frame 141 to descend until the disposable magnetic separation sleeve extends into the cleaning liquid. After that, the third driving element 142 drives the magnetic rod 1435 to rise from the disposable magnetic separation sleeve to make the magnetic field disappear, and the magnetic particles are separated from the outer wall of the disposable magnetic separation sleeve and fall off and enter the cleaning liquid.

[0097] In order to speed up the separation process of the magnetic particles, the first driving element 12 can drive the second mounting frame 141 to rise and fall repeatedly at different frequencies so that the magnetic particles repeatedly move in the cleaning solution, thereby ensuring that the magnetic particles and the cleaning solution are fully mixed and suspended. After the magnetic particles are completely separated from the outer wall of the disposable magnetic separation sleeve, the first driving element 12 drives the second mounting frame 141 to rise to the initial height to complete the separation, cleaning and mixing operation of the magnetic particles. If multiple magnetic separation and cleaning are required, the above operation can be repeated.

[0098] Similarly, if it is necessary to transfer the magnetic particles to other hole positions, just control the first driving element 12 to drive the second mounting frame 141 to descend until the disposable magnetic separation sleeve extends into the bottom of the corresponding liquid surface, and then control the third driving element 142 to drive the magnetic rod 1435 to descend until it contacts the bottom end of the disposable magnetic separation sleeve, so that all the magnetic particles are adsorbed on the outer wall of the disposable magnetic separation sleeve, and control the first driving element 12 to drive the second mounting frame 141 to rise.

[0099] Afterwards, the reaction chamber device 30 is controlled to move until the disposable magnetic separation sleeve adsorbed with magnetic particles moves to the top of the target hole, and then the first driving element 12 is controlled to drive the second mounting frame 141 to descend until the disposable magnetic separation sleeve extends into the target liquid. At this time, the third driving element 142 is controlled to drive the magnetic rod 1435 to rise to make the magnetic field disappear, and the magnetic particles can be gradually separated into the target liquid. The first driving element 12 can be controlled to repeatedly drive the second mounting frame 141 to rise and fall, so that the disposable magnetic separation sleeve can be repeatedly moved in the target liquid to accelerate the separation and mixing of the magnetic particles.

[0100] See also Fig. 9 Furthermore, the sample pre-processing mechanism 14 also includes:

[0101] A first slide rail 144 disposed on the second mounting frame 141 , the first slide rail 144 being distributed along a height direction of the second mounting frame 141 ; and

[0102] The first sliding block 145 is disposed on the first pushing plate 1433 , and the first sliding block 145 is slidably connected to the first sliding rail 144 .

[0103] Furthermore, in order to ensure that the first push plate 1433 can stably drive at least two rows of magnetic bars 1435 to rise and fall, a first slide rail 144 extending in the vertical direction is arranged on the second mounting frame 141, and a first slider 145 adapted to the first slide rail 144 is arranged on the first push plate 1433. The stable movement of the first push plate 1433 relative to the second mounting frame 141 is achieved through the cooperation between the first slide rail 144 and the first slider 145.

[0104] The first slide rail 144 and the first slider 145 are divided into two groups, which are respectively arranged on the left and right sides of the sample pre-processing mechanism 14 to further ensure the smooth lifting and lowering of the first push plate 1433 .

[0105] See also Figure 8 , further, the extraction component 133 includes:

[0106] An injection device 1331 is arranged on the first mounting frame 131, wherein a syringe cavity is formed in the injection device 1331, and a first loading head 1332 for loading a tip head is arranged at the bottom of the injection device 1331, and the first loading head 1332 is communicated with the syringe cavity;

[0107] A second push plate 1333 disposed above the injection device 1331, the second push plate 1333 is drivingly connected to the second driving element 132; and

[0108] The piston rod 1334 is arranged on the second push plate 1333 and is movably and sealedly connected to the syringe cavity. The second driving element 132 can drive the first push plate 1333 to drive the piston rod 1334 to rise and fall in the syringe cavity to perform a suction and exhalation action.

[0109] Specifically, the injection device is distributed along the width direction of the first mounting frame 131, so that the injection cavity therein can be distributed in the width direction of the extraction assembly 133 to correspond to the location of the reagent strip. The injection device 1331 also has a certain height to ensure that the space of the injection cavity is large enough, so that the piston rod 1334 can generate a sufficiently large suction and discharge force when moving in the injection cavity.

[0110] The first loading head 1332 and the tip head are interference fit, thereby ensuring the stability of the tip head loaded on the first loading head 1332. When the first driving element 12 drives the first mounting frame 131 to drive the extraction assembly 133 to descend, the corresponding sealing film on the reagent strip can be broken by the tip head loaded on the first loading head 1332. The first loading head 1332 is connected to the syringe cavity, which makes the syringe cavity connected to the tip head. When the piston rod 1334 is pushed up and down in the syringe cavity, the sample can be sucked and discharged through the tip head.

[0111] The transmission shaft of the second driving element 132 extends downward through the top of the first mounting frame 131 and the first push plate 1333. A fixing piece threadedly connected to the transmission shaft can be set on the transmission shaft, and the first push plate 1333 can be fixed on the fixing piece. When the transmission shaft of the second driving element 132 moves, the first push plate 1333 can be driven to rise and fall through the fixing piece to realize the lifting and lowering of the piston rod 1334.

[0112] Alternatively, a screw hole may be provided on the first push plate 1333, and a thread may be provided on the transmission shaft of the second driving element 132, so that the transmission shaft is threadedly connected to the first push plate 1333. This can ensure the stability of the connection between the two, and the second driving element 132 can also drive the first push plate 1333 to rise and fall by threaded driving.

[0113] In this embodiment, the end of the piston rod 1334 in the syringe cavity can be sealed with the syringe cavity by a sealing ring (such as a rubber ring or a plastic ring, etc.). When the piston rod 1334 is driven upward by the first push plate 1333 and rises in the syringe cavity, negative pressure is generated in the syringe cavity to make the tip absorb the sample, and when the piston rod 1334 is pushed downward by the first push plate 1333 and descends in the syringe cavity, positive pressure is generated in the syringe cavity to make the tip spit out the sample.

[0114] Furthermore, a photoelectric switch can be arranged on the top of the first mounting frame 131, and a baffle can be arranged on the corresponding side of the first push plate 1333. When the first push plate 1333 drives the baffle to move to the photoelectric switch to disconnect the sensing of the photoelectric switch, it indicates that the first push plate 1333 has moved to the set height, that is, it indicates that the piston rod 1334 has been reset. At this time, the power supply of the second driving element 132 can be disconnected to prevent the second driving element 132 from being continuously operated and overloaded and damaged.

[0115] Please continue reading Figure 8 Furthermore, the sample extraction mechanism 13 also includes:

[0116] A push rod 1335 is lifted and lowered through the injection device 1331, and a top end of the push rod 1335 is spaced apart from the first push plate 1333;

[0117] An elastic element 1336 is sleeved on a push rod 1335 in the injection device 1331, and the elastic element 1336 is stretched or compressed simultaneously when the push rod 1335 is lifted or lowered relative to the injection device 1331; and

[0118] A separation plate 1337 is provided at the bottom of the injection device 1331 , and the first loading head 1332 passes through the separation plate 1337 . The bottom end of the push rod 1335 is connected to the separation plate 1337 , and the push rod 1335 can drive the separation plate 1337 to rise and fall relative to the first loading head 1332 .

[0119] In an embodiment of the present invention, a through hole is provided on the separation plate 1337, and the size of the through hole is smaller than the size of the connection between the tip head and the first loading head 1332. Therefore, the tip head loaded on the first loading head 1332 can be removed by setting the separation plate 1337.

[0120] Specifically, since the top end of the push rod 1335 is spaced from the first push plate 1333, when the first push plate 1333 is pushed down a certain height by the second driving element 132 to contact with the top end of the push rod 1335, the first push plate 1333 pushes the push rod 1335 to descend in the injection device 1331, thereby pushing the separation plate 1337 located at the bottom of the injection device 1331 to descend and abut against the tip head, so as to push the tip head to separate from the first loading head 1332.

[0121] After the tip is separated, the second driving element 132 stops driving, and the elastic element 1336 stretches to generate an upward thrust on the push rod 1335, driving the separation plate 1337 to reset. The compression of the elastic element 1336 can provide a certain buffer force for the descent of the push rod 1335, so as to prevent the push rod 1335 from descending too fast and causing the tip to be pressed and damaged, or the tip is pressed on the reagent strip, causing the reagent strip to deviate and shake.

[0122] In the embodiment of the present invention, there are two push rods 1335 and elastic elements 1336, which are respectively arranged on both sides of the injection device 1331 to ensure that the push rod 1335 pushes the separation plate 1337 smoothly, thereby ensuring the separation effect of the tip head, and ensuring that the elastic element 1336 smoothly resets the separation plate 1337.

[0123] See also Figure 5 and Figure 8Furthermore, there are multiple syringe cavities, and the multiple syringe cavities are evenly distributed in the injection device 1331 along the length direction of the injection device 1331; there are multiple first loading heads 1332, and the multiple first loading heads 1332 are evenly distributed at the bottom of the injection device 1331 along the length direction of the injection device 1331; there are multiple piston rods 1334, and the multiple piston rods 1334 are evenly distributed on the first push plate 1333 along the length direction of the first push plate 1333.

[0124] That is, the multiple piston rods 1334, the multiple syringe cavities and the multiple piston rods 1334 correspond one to one, thereby realizing multi-channel parallel processing of multiple reagent strips.

[0125] See also Figure 8 Furthermore, the sample extraction mechanism 13 also includes:

[0126] a second slide rail 134 disposed between the injection device 1331 and the second push plate 1333; and

[0127] The second sliding block 135 is disposed on the second pushing plate 1333 , and the second sliding block 135 is slidably connected to the second sliding rail 134 .

[0128] Furthermore, in order to ensure that the second push plate 1333 can stably drive the piston rod 1334 to rise and fall, a second slide rail 134 extending in the vertical direction is provided on the injection device 1331, and a second slider 135 adapted to the second slide rail 134 is provided on the second push plate 1333. The stable movement of the second push plate 1333 relative to the first mounting frame 131 is achieved through the cooperation between the second slide rail 134 and the second slider 135.

[0129] The second slide rail 134 and the second slider 135 are two groups, which are respectively disposed on the left and right sides of the sample extraction mechanism 13 to further ensure the smooth lifting of the second push plate 1333 .

[0130] See also Figure 3 , Figure 6 and Figure 7 Furthermore, a movable space 111 is provided on the gantry 11, a transmission shaft of the first driving element 12 passes through the movable space 111, a transmission plate 112 is sleeved on the transmission shaft, a thread is provided on the transmission shaft, and a screw hole is provided on the transmission plate 112. Therefore, when the transmission shaft moves, the transmission plate 112 can be synchronously lifted and lowered in the movable space 111 by thread transmission.

[0131] A first connecting portion is provided on the side of the first mounting frame 131 facing the gantry 11, and the first connecting portion is formed by a vertical extension plate of the first mounting frame 131 extending toward the gantry 11. A second connecting portion is provided on the side of the second mounting frame 141 facing the gantry 11, and the second extension portion is formed by a vertical extension plate of the second mounting frame 141 extending toward the gantry 11. Both the first connecting portion and the second connecting portion are connected to the transmission plate 112 by fasteners (such as screws). Therefore, when the transmission plate 112 is lifted or lowered along with the transmission shaft of the first driving element 12, the first mounting frame 131 and the second mounting frame 141 can be driven to lift or lower, thereby realizing the lifting or lowering of the sample extraction mechanism 13 and the sample pre-processing mechanism 14 on the gantry 11.

[0132] Exemplarily, the process of the sample extraction mechanism 13 sucking and discharging the sample (and transferring / mixing the reagent) is roughly as follows:

[0133] When the reaction chamber device 30 drives the reagent strip to move to the corresponding position, the first driving element 12 drives the first mounting frame 131 to descend to the first loading head 1332 to cooperate and fix with the tip head on the reagent strip.

[0134] After the tip head is loaded, the reaction chamber device 30 drives the reagent strip to move until the tip head moves to above the sample hole. At the same time, the second driving element 132 first drives the piston rod 1334 to descend a certain height or to the lowest point in the syringe cavity. Then, the first driving element 12 drives the first mounting frame 131 to descend a certain height until the tip of the tip head extends into the sample. The second driving element 132 drives the piston rod 1334 to rise to absorb the sample through the tip head. Then, the first driving element 12 drives the first mounting frame 131 to rise to make the tip head separate from the sample liquid surface. The reaction chamber device 30 drives the reagent strip to move until the tip head with the sample absorbed moves to directly above the target hole position.

[0135] The first driving element 12 drives the first mounting frame 131 to descend, driving the tip head with the sample absorbed to descend until its tip is inserted below the liquid surface of the reagent, and the second driving element 132 drives the piston rod 1334 to descend to inject the sample in the tip head into the reagent, then the first driving element 12 drives the first mounting frame 131 to rise until the tip head is separated from the reagent, and the second driving element 132 drives the piston rod 1334 to rise to its original position, realizing the suction and transfer of the sample, and then retracting the tip head into the tip head hole on the reagent strip.

[0136] The reagent transfer process is the same as the sample transfer process and will not be described in detail here.

[0137] If multiple transfers are required, the tip head can be repeatedly loaded and the suction and injection actions can be repeated. In addition, the sample extraction mechanism 13 can also be used to mix the reagents, and the second driving element 132 is controlled to drive the piston rod 1334 to rise and fall repeatedly in the syringe cavity, so that the tip head repeatedly sucks and discharges under the reagent liquid surface, so that the reagents or samples that need to react can be fully mixed and reacted.

[0138] Furthermore, a third slider 136 may be provided on the side of the first mounting frame 131 facing the gantry 11, and a third slide rail 113 extending along the height direction of the gantry 11 may be provided on the side of the gantry 11 facing the first mounting frame 131. The third slider 136 is slidably connected to the third slide rail 113, and the third slider 136 and the third slide rail 113 are two groups, which are respectively arranged on the left and right sides of the gantry 11 and the first mounting frame 131. Through the cooperation of the two groups of third sliders 136 and the third slide rail 113, it can be ensured that the first driving element 12 drives the first mounting frame 131 on the gantry 11 to rise and fall smoothly, thereby ensuring that the sample extraction mechanism 13 rises and falls smoothly and accurately.

[0139] In addition, a fourth slider 146 may be provided on the side of the second mounting frame 141 facing the gantry 11, and a fourth slide rail 114 extending along the height direction of the gantry 11 may be provided on the side of the gantry 11 facing the second mounting frame 141. The fourth slider 146 is slidably connected to the fourth slide rail 114, and the fourth slider 146 and the fourth slide rail 114 are two groups, which are respectively arranged on the left and right sides of the gantry 11 and the second mounting frame 141. Through the cooperation of the two groups of fourth sliders 146 and the fourth slide rail 114, it can be ensured that the first driving element 12 drives the second mounting frame 141 on the gantry 11 to rise and fall smoothly, thereby ensuring that the sample pre-processing mechanism 14 rises and falls smoothly and accurately.

[0140] A first detector 115 (such as a photoelectric switch) may be disposed on one side of the top of the gantry 11, and a first induction member 137 (such as a baffle) may be disposed on one side of the top of the first mounting frame 131. The first induction member 137 may generate or disconnect induction with the first detector 115 as the first mounting frame 131 rises and falls. When the first mounting frame 131 drives the first induction member 137 to move to the first detector 115 to disconnect the induction, it indicates that the sample extraction mechanism 13 has moved to the set height, and at this time, the power supply of the first driving element 12 may be disconnected to prevent the first driving element 12 from being overloaded and damaged.

[0141] In addition, a second detector (such as a photoelectric switch) can be arranged on the other side of the top of the gantry 11, and a second induction member (such as a baffle) can be arranged on one side of the top of the second mounting frame 141. The second induction member can generate or disconnect induction with the second detector as the second mounting frame 141 rises and falls. When the second mounting frame 141 drives the second induction member to move to the second detector to disconnect the induction, it indicates that the sample pre-processing mechanism 14 has moved to the set height. At this time, the power supply of the third driving element 142 can be disconnected to prevent the third driving element 142 from being overloaded and damaged.

[0142] See also Figures 1 to 9 The POCT fully automatic chemiluminescence device 100 of the embodiment of the present invention comprises:

[0143] Mounting frame 20;

[0144] A reaction chamber device 30 disposed on the mounting frame 20, the reaction chamber device 30 can reciprocate along the length direction of the mounting frame 20, and the reaction chamber device 30 is used to load a reagent strip;

[0145] A PMT device 40 is disposed at the rear end of the mounting frame 20 and located above the reaction chamber device 30. The reaction chamber device 30 is used to move the reagent strip to the PMT device 40. The PMT device 40 is used to detect the luminescence value of the detection position of the reagent strip; and

[0146] According to any of the above multi-channel multi-joint test parallel pre-processing devices 10, the multi-channel multi-joint test parallel pre-processing device 10 is used to aspirate and discharge samples from reagents in a reagent strip and transfer magnetic particles.

[0147] In the POCT fully automatic chemiluminescence device 100 of the embodiment of the present invention, the pre-treatment component 143 in the multi-channel multi-joint detection parallel pre-treatment device 10 includes at least two rows of magnetic bars 1435 for transferring magnetic particles, and each row of magnetic bars 1435 has at least two magnetic bars, that is, the pre-treatment component 143 can simultaneously transfer the magnetic particles in at least two reagent wells on a single reagent strip, and transfer the magnetic particles in at least two reagent strips arranged in parallel, thereby realizing the detection of at least two items, realizing multi-joint detection while realizing multi-channel parallel processing, and realizing the multi-channel multi-joint detection function of the multi-channel multi-joint detection parallel pre-treatment device 10, which can reduce the risk of cross infection, control the time and equipment volume for transferring magnetic particles, and ensure the analysis efficiency of the equipment for multiple items.

[0148] In an embodiment, the reaction chamber device 30 can be disposed on the bottom plate of the mounting frame 20, and driving elements such as a motor and a guide rail extending along the length direction of the mounting frame 20 can be disposed on the bottom plate. A slide corresponding to the guide rail can be disposed at the bottom of the reaction chamber device 30. Through the cooperation between the slide and the guide rail, the reaction chamber device 30 can be slidably disposed on the mounting frame 20 to realize reciprocating movement, thereby moving the reagent strip to the corresponding position for corresponding detection and analysis.

[0149] Since the reaction chamber device 30 is arranged on the bottom plate of the mounting frame 20, the PMT device 40 can be arranged above the bottom plate through a bracket or other structure, that is, the PMT device 40 is located relatively above the reaction chamber device 30. To ensure that the PMT device 40 can detect the luminescence values ​​of all reagent strips in the reaction chamber device 30, the PMT device 40 can move up, down, left and right on the bracket, that is, it can move in the vertical direction and the horizontal direction (the width direction of the mounting frame 20), so as to approach or move away from the reagent strip and move back and forth between multiple reagent strips to achieve corresponding detection.

[0150] The reaction chamber device 30 and the PMT device 40 are not related to the inventive aspects of the present invention and will not be described in detail herein.

[0151] In the description of this specification, the description with reference to the terms "Example 1", "Example 2", etc. means that the specific features, structures, materials or characteristics described in conjunction with the implementation or example are included in at least one implementation or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same implementation or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more implementations or examples in a suitable manner.

[0152] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A multi-channel multi-joint inspection parallel pre-processing device, characterized in that: include: A gantry, wherein a first driving element is provided on the top of the gantry; A sample extraction mechanism is arranged on the gantry, the sample extraction mechanism comprises a first mounting frame arranged on the gantry and drivingly connected to the first driving element, a second driving element arranged on the first mounting frame, and an extraction component arranged on the first mounting frame and drivingly connected to the second driving element, the second driving element can drive the first mounting frame to rise and fall, and the second driving element can drive the extraction component to rise and fall to suck and discharge samples; as well as A sample pre-processing mechanism disposed on the gantry, the sample pre-processing mechanism comprising a second mounting frame disposed on the gantry and drivingly connected to the first driving element, a third driving element disposed on the second mounting frame, and a pre-processing assembly disposed on the second mounting frame and drivingly connected to the third driving element, wherein the first driving element can drive the second mounting frame to rise and fall; The pre-processing component comprises at least two rows of magnetic bars arranged side by side along the width direction of the pre-processing component, each row has at least two magnetic bars, and the third driving element can drive the pre-processing component to rise and fall to transfer magnetic particles through at least two rows of magnetic bars.

2. The multi-channel multi-joint inspection parallel pre-processing device according to claim 1, characterized in that: The pre-processing component comprises: A magnetic bar device is arranged on the second mounting frame, wherein a plurality of movable through holes are formed in the magnetic bar device, and a plurality of first loading heads for loading disposable magnetic separation sleeves are arranged at the bottom of the magnetic bar device, and the plurality of first loading heads are connected to the plurality of movable through holes in a one-to-one correspondence; a first push plate disposed above the magnetic bar device, the first push plate being drivingly connected to the third driving element; and There are multiple connecting rods arranged on the first pushing plate, and at least two rows of magnetic bars are arranged one by one on the free ends of the multiple connecting rods. The third driving element can drive the first pushing plate to drive the magnetic bars to rise and fall in the corresponding active through holes so as to be separated from the first loading head or pass through the first loading head.

3. The multi-channel multi-joint inspection parallel pre-processing device according to claim 2, characterized in that: The magnetic bars are arranged in multiple rows, and the magnetic bars in the multiple rows are evenly distributed along the width direction of the first push plate; There are multiple magnetic bars in each row, and the multiple magnetic bars in each row are evenly spaced and distributed along the length direction of the first pushing plate.

4. The multi-channel multi-joint inspection parallel pre-processing device according to claim 2, characterized in that: The sample pre-processing mechanism also includes: a first slide rail disposed on the second mounting frame, wherein the first slide rail is distributed along a height direction of the second mounting frame; and A first sliding block is disposed on the first pushing plate, and the first sliding block is slidably connected to the first sliding rail.

5. The multi-channel multi-joint inspection parallel pre-processing device according to claim 1, characterized in that: The extraction component comprises: An injection device arranged on the first mounting frame, wherein a plurality of injection cavities are formed in the injection device, a plurality of second loading heads for loading tip heads are arranged at the bottom of the injection device, and the plurality of second loading heads are connected to the plurality of injection cavities in a one-to-one correspondence; a second push plate disposed above the injection device, the second push plate being drivingly connected to the second driving element; and A plurality of piston rods are arranged on the second push plate, and the piston rods are movably and sealedly connected to the syringe cavity. The second driving element can drive the second push plate to drive the piston rods to rise and fall in the syringe cavity to perform a suction and exhalation action.

6. The multi-channel multi-joint inspection parallel pre-processing device according to claim 5, characterized in that: The sample extraction mechanism also includes: A push rod that can be lifted and lowered and passes through the injection device, wherein the top end of the push rod is spaced apart from the second push plate; an elastic element sleeved on the push rod in the injection device, wherein the elastic element is stretched or compressed simultaneously when the push rod is lifted or lowered relative to the injection device; and A separation plate is arranged at the bottom of the injection device, the second loading head passes through the separation plate, the bottom end of the push rod is connected to the separation plate, and the push rod can drive the separation plate to rise and fall relative to the second loading head.

7. The multi-channel multi-joint inspection parallel pre-processing device according to claim 5, characterized in that: The plurality of syringe cavities are evenly distributed along the length direction of the injection device, the plurality of second loading heads are evenly distributed along the length direction of the injection device, and the plurality of piston rods are evenly distributed along the length direction of the second push plate.

8. The multi-channel multi-joint inspection parallel pre-processing device according to claim 5, characterized in that: The sample extraction mechanism also includes: a second slide rail disposed between the injection device and the second push plate; and A second sliding block is arranged on the second pushing plate, and the second sliding block is slidably connected to the second sliding rail.

9. The multi-channel multi-joint inspection parallel pre-processing device according to claim 1, characterized in that: The sample extraction mechanism is opposite to the sample pre-processing mechanism, and the sample extraction mechanism is located in front of the sample pre-processing mechanism, and the first driving element, the second driving element and the third driving element are linearly arranged on the top of the gantry.

10. The multi-channel multi-joint inspection parallel pre-processing device according to claim 1, characterized in that: The gantry is provided with an activity space, the transmission shaft of the first driving element passes through the activity space, a transmission plate is sleeved on the transmission shaft, and the transmission plate can be raised and lowered in the activity space when the transmission shaft moves; A first connection portion is provided on a side of the first mounting frame facing the gantry, and a second connection portion is provided on a side of the second mounting frame facing the gantry. Both the first connection portion and the second connection portion are connected to the transmission plate.

11. The multi-channel multi-joint inspection parallel pre-processing device according to claim 1, characterized in that: A third slider is provided on a side of the first mounting frame facing the gantry, a third slide rail is provided on a side of the gantry facing the first mounting frame, the third slide rail extends along the height direction of the gantry, and the third slider is slidably connected to the third slide rail; A fourth slider is disposed on a side of the second mounting frame facing the gantry, a fourth slide rail is disposed on a side of the gantry facing the second mounting frame, the fourth slide rail extends along the height direction of the gantry, and the fourth slider is slidably connected to the fourth slide rail.

12. The multi-channel multi-joint inspection parallel pre-processing device according to claim 1, characterized in that: A first sensing element is provided on one side of the top of the first mounting frame, and a first detector is provided on one side of the top of the gantry frame. The first sensing element can generate or disconnect induction with the first detector as the first mounting frame rises and falls; A second sensing member is provided on one side of the top of the second mounting frame, and a second detector is provided on one side of the top of the gantry frame. The second sensing member can generate or disconnect induction with the second detector as the second mounting frame rises and falls.

13. A POCT fully automatic chemiluminescence device, characterized in that: include: Install the frame; A reaction chamber device disposed on the mounting frame, the reaction chamber device being reciprocatable along the length direction of the mounting frame, the reaction chamber device being used to load a reagent strip; A PMT device disposed at the rear end of the mounting frame and located above the reaction chamber device, the reaction chamber device is used to move the reagent strip to the PMT device, and the PMT device is used to detect the luminescence value of the detection position of the reagent strip; as well as According to any one of claims 1 to 12, the multi-channel multi-joint detection parallel pre-processing device is used to aspirate samples and transfer magnetic particles from the reagent strip.

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