A herbicidal composition containing mesosulfuron and its preparation method and application

Abstract

The present application relates to the field of pesticide weed control technology, and more particularly to a herbicidal composition containing methyl disulfonyl and its preparation method and application. A herbicidal composition containing methyl disulfonyl is made up of the following components by mass percentage: methyl disulfonyl 1%, emulsifier 18%, safener 3%, stabilizer 2.7%, organobentonite 1 3%, white carbon 2 3%, surfactant 3 3.5%, soybean first-class salad oil is supplemented to 100%, wherein the stabilizer is prepared by mixing triphenylethylphenol polyether ammonium sulfate, naphthalenesulfonate formaldehyde condensate and diatomaceous earth with a mass ratio of 5: 7: 15, and the diatomaceous earth average particle size is 5.2 μm. The herbicidal composition containing methyl disulfonyl provided in the present application takes into account environmental safety, crop safety and economic cost while ensuring the weeding effect, and is an ideal herbicide selection.

Description

Technical Field

[0001] The present application relates to the technical field of pesticide weed control, and in particular to a herbicidal composition containing mesosulfuron-methyl, and a preparation method and application thereof. Background Art

[0002] Wheat is my country's third-largest grain crop, after corn and rice, accounting for over 20% of the nation's total grain output. Therefore, ensuring consistently high wheat yields is crucial for maintaining my country's grain self-sufficiency and ensuring national food security. However, wheat production faces numerous threats, with weeds being a major factor. Weed infestation in my country's wheat fields accounts for over 90% of the cultivated area, resulting in yield losses of up to 15%. Furthermore, with rising labor costs in my country, the use of herbicides to control weed damage in wheat fields has become essential for wheat production.

[0003] Mesosulfuron is a sulfonylurea herbicide, primarily absorbed through plant stems and leaves, conducted through the phloem and xylem, and absorbed to a lesser extent through the soil. It inhibits the activity of acetolactate synthase in sensitive plants, hindering the synthesis of branched-chain amino acids, thereby inhibiting cell division and causing the death of sensitive plants. It can be used in wheat fields to control a variety of grass weeds, such as foxtail millet, wild oats, clover, bluegrass, hard grass, alkaligrass, multiflora ryegrass, typhina, bromegrass, candlewort, aesculus tauschii, and rush, but its effectiveness against broadleaf weeds is less than ideal. Furthermore, when conventional mesosulfuron is used as a herbicide in wheat fields, the mesosulfuron content is between 3% and 4%, which is high, unsafe, and poses a risk of phytotoxicity. Summary of the Invention

[0004] The present application aims to address the shortcomings of current technologies by providing a herbicidal composition containing mesosulfuron, its preparation method, and its application. The herbicidal composition containing mesosulfuron prepared in this application not only has excellent control efficacy against resistant weeds, reducing the dosage of the agent, but is also safe for wheat and has no effect on subsequent crops. It is an ideal herbicide with broad application prospects. Surfactants can improve the adhesion and conductivity of mesosulfuron on weed leaves in wheat fields, allowing mesosulfuron to better adhere to weed leaves and stems, enhancing its weed control effectiveness and ensuring safety for wheat.

[0005] In the first aspect, the present application provides a herbicidal composition containing mesosulfuron-methyl, which adopts the following technical solution:

[0006] A herbicidal composition containing mesosulfuron is prepared from the following components by mass percentage: 1% mesosulfuron, 18% emulsifier, 3% safener, 2.7% stabilizer, 1-3% organic bentonite, 2-3% white carbon black, 3-3.5% surfactant, and first-grade soybean salad oil (complemented to 100%). The stabilizer is prepared by mixing triphenethylphenol polyether ammonium sulfate, naphthalenesulfonate formaldehyde condensate, and diatomaceous earth in a mass ratio of 5:7:15, and the diatomaceous earth has an average particle size of 5.2 μm.

[0007] By employing the above technical solution, mesosulfuron, as the main active ingredient, is a sulfonylurea herbicide. It is absorbed and transported through the stems and leaves of plants, inhibiting the activity of acetolactate synthase in sensitive plants, leading to blocked branched-chain amino acid synthesis, which in turn inhibits cell division and causes the death of sensitive plants. It can be used to control various grass weeds in wheat fields. The emulsifier helps evenly disperse mesosulfuron in water, forming a stable emulsion and improving its adhesion and conductivity to plant surfaces. The safener acts synergistically with mesosulfuron, enhancing its weed control effectiveness while reducing the risk of phytotoxicity to wheat, thereby improving wheat safety, yield, and quality. The stabilizers (triphenylethylphenol polyether ammonium sulfate, naphthalenesulfonate formaldehyde condensate, and diatomaceous earth) help maintain the stability of the herbicide, preventing decomposition or inactivation of the active ingredient, and enhancing the overall performance of the herbicide composition. Diatomaceous earth also has excellent adsorption properties, facilitating adhesion of the herbicide to plant surfaces. Organic bentonite: has good adsorption and swelling properties, which helps the agent adhere to and conduct on the plant surface. White carbon black: has adsorption properties, which helps the agent adhere to the plant surface. Surfactant: can improve the adhesion and conductivity of methyldisulfonyl on the weed leaves in wheat fields, so that methyldisulfonyl can better adhere to the weed leaves and stems, and improve the weed control effect of methyldisulfonyl. First-grade soybean salad oil: as a solvent, it helps to dissolve and disperse the agent, and at the same time has a certain lubricating effect, which is beneficial to the adhesion and conduction of the agent on the plant surface. In summary, the herbicidal composition containing methyldisulfonyl in the present application achieves good prevention effect on resistant weeds through the synergistic effect of each component, reduces the dosage of the agent, improves the safety of wheat, has no effect on subsequent crops, and has broad application prospects.

[0008] Preferably, the preparation method of mesosulfuron-methyl comprises the following steps:

[0009] S21, 700g of dichloromethane and 35g of bis(trichloromethyl) carbonate were added to a dry reaction flask, and the mixture was stirred. After the bis(trichloromethyl) carbonate was dissolved, the solution was cooled to 3°C, and the pyrimidineamine solution was added dropwise to the bis(trichloromethyl) carbonate solution. After the addition, the mixture was stirred for 35min, and then 100g of triethylamine was added dropwise. After the addition, the mixture was stirred for 1h to obtain a solution A for standby use; the temperature was controlled below 45°C during the reaction;

[0010] S22. Add 69 g of 5-methanesulfonylaminomethyl-2-methoxycarbonylbenzenesulfonamide and 150 g of dichloromethane to another dry reaction flask, cool to 3°C, and slowly add Solution A with stirring. The reaction is exothermic. Control the addition rate of Solution A so that the system temperature does not exceed 30°C.

[0011] S23. After adding solution A, continue stirring for 3 hours, add 1 L of deionized water, stir thoroughly, let stand to separate the layers, separate the organic phase, acidify the aqueous phase with 0.1 L of 2M hydrochloric acid, filter the precipitated solid, and dry to obtain methyldisulfonyl with a purity of 99.5%.

[0012] By adopting the above technical solution, mesosulfuron-methyl is a highly effective herbicide with good control effect on resistant weeds. In the preparation process of the present application, high-purity mesosulfuron-methyl can be effectively obtained through specific chemical reaction steps.

[0013] Preferably, in step S21, the pyrimidineamine solution is prepared by dissolving 35 g of pyrimidineamine in 100 g of dichloromethane.

[0014] Preferably, the emulsifier is emulsifier 8801 produced by Nanjing Kehong Chemical Co., Ltd.

[0015] Preferably, the safener is at least one of mefenpyr-butyl, ethyl 5-phenyl-4,5-dihydroisoxazole-3-carboxylate and 5-aminolevulinic acid.

[0016] Preferably, the safener is prepared by mixing mefenpyr-butyl, ethyl 5-phenyl-4,5-dihydroisoxazole-3-carboxylate and 5-aminolevulinic acid in a mass ratio of 3:4:3.

[0017] By adopting the above technical solution, the safener is prepared by mixing mefenpyr-butyl, ethyl 5-phenyl-4,5-dihydroisoxazole-3-carboxylate, and 5-aminolevulinic acid in a mass ratio of 3:4:3. The synergistic effect of these three compounds in the safener is mainly manifested in the following aspects: It improves the weed control effect of mesosulfuron-butyl: mefenpyr-butyl, ethyl 5-phenyl-4,5-dihydroisoxazole-3-carboxylate, and 5-aminolevulinic acid all enhance plant resistance, thereby improving the weed control effect of mesosulfuron-butyl. It also reduces the risk of phytotoxicity to wheat: mefenpyr-butyl, ethyl 5-phenyl-4,5-dihydroisoxazole-3-carboxylate, and 5-aminolevulinic acid all protect plants from drug damage, thereby reducing the risk of phytotoxicity to wheat caused by mesosulfuron-butyl. Improve wheat safety, yield and quality: pyraclostrobin, 5-phenyl-4,5-dihydroisoxazole-3-carboxylic acid ethyl ester and 5-aminolevulinic acid all have the effect of promoting plant growth and development, and can improve the safety, yield and quality of wheat. In summary, the safener is prepared by mixing pyraclostrobin, 5-phenyl-4,5-dihydroisoxazole-3-carboxylic acid ethyl ester and 5-aminolevulinic acid in a mass ratio of 3:4:3. Its role in this application is to enhance the weed control effect of methyldisulfuron, reduce the hidden dangers of wheat damage, and improve wheat safety, yield and quality.

[0018] Preferably, the surfactant is prepared by mixing lauryl alcohol polyethylene glycol ether acetal, alkylphenol polyoxyethylene ether phosphate and alkyl polyoxyethylene ether sulfonate in a mass ratio of 5:4:4.

[0019] By adopting the above technical solution, surfactants play a crucial role in mesosulfuron-methyl herbicides because they improve the adhesion and transport of mesosulfuron to weed leaves. This improvement allows mesosulfuron to better adhere to weed leaves and stems, thereby enhancing its weed control effectiveness. Furthermore, surfactants improve wheat safety and reduce potential damage to wheat caused by the agent. The surfactant is prepared by mixing lauryl alcohol polyglycol ether acetal, alkylphenol polyoxyethylene ether phosphate, and alkylpolyoxyethylene ether sulfonate in a mass ratio of 5:4:4. These three components interact synergistically, enhancing both the herbicidal efficacy of mesosulfuron-methyl and the safety of wheat. Lauryl alcohol polyglycol ether acetal has excellent wettability and permeability, helping mesosulfuron to better adhere to weed surfaces and promote its transport within the plant. Alkylphenol polyoxyethylene ether phosphate has excellent emulsifying and dispersing properties, helping mesosulfuron to evenly distribute on weed surfaces, improving its efficacy. Alkyl polyoxyethylene ether sulfonates, on the other hand, have excellent surface activity and stability, enhancing the adhesion of mesosulfuron to weed surfaces while reducing damage to wheat. In summary, through the synergistic effect of these three surfactants, the mesosulfuron-containing herbicidal composition prepared in this application not only has excellent control effectiveness against resistant weeds, reducing the dosage of the agent, but is also safe for wheat and has no impact on subsequent crops. It is an ideal herbicide with broad application prospects.

[0020] Preferably, the average particle size of the white carbon black is 5 microns, and the average particle size of the organic bentonite is 325 meshes.

[0021] In a second aspect, the present application provides a method for preparing a herbicidal composition containing mesosulfuron-methyl, using the following technical solution:

[0022] As a general technical concept, the present application also provides a method for preparing the above-mentioned herbicidal composition containing mesosulfuron, comprising the following steps: mixing mesosulfuron, an emulsifier, a safener, a stabilizer, an organic bentonite, white carbon black, a surfactant and first-grade soybean salad oil according to the formulated amount and stirring them uniformly to obtain a herbicidal composition containing mesosulfuron.

[0023] In a third aspect, the present application provides an application of a herbicidal composition containing mesosulfuron-methyl, using the following technical solution:

[0024] As a general technical concept, the present application also provides the use of the above-mentioned herbicide composition containing mesosulfuron-methyl for controlling annual weeds in winter wheat fields, using a stem and leaf spray method with a dosage of 60-100 mL per mu.

[0025] In summary, the beneficial technical effects of this application are:

[0026] 1. Improve weed control effect: The surfactant improves the adhesion and conductivity of mesosulfuron on the weed leaves, allowing the agent to better act on the weeds and improving the control effect on grass weeds such as foxtail millet, wild oats, and sedge.

[0027] 2. Reduce the amount of medicine used: Due to the synergistic effect of mesosulfuron, safener, stabilizer and other ingredients in the composition, a good weed control effect can be achieved at a lower dosage, reducing the use of chemical agents.

[0028] 3. Improve crop safety: The addition of safeners not only improves the weed control effect, but also reduces the risk of pesticide damage to crops such as wheat, ensuring the growth safety and yield quality of crops.

[0029] 4. Environmentally friendly: Reducing the use of chemical pesticides helps to alleviate pollution pressure on the environment, and the composition has no adverse effects on subsequent crops, which is conducive to the sustainable development of agriculture.

[0030] 5. Wide application: The composition can be used to control a variety of grass weeds in wheat fields, with a wide weed control spectrum and good application prospects.

[0031] 6. Good stability: Through the specific stabilizer formula, the stability of mesosulfuron in the preparation is ensured, the shelf life of the product is extended, and it is convenient for storage and use.

[0032] 7. Economic benefits: Due to its high weed control ability and safety to crops, farmers can reduce losses caused by weeds and reduce the increased costs caused by excessive use of chemicals, thereby improving economic benefits. DETAILED DESCRIPTION

[0033] The embodiments of the present application will be described in detail below with reference to the examples, but it will be understood by those skilled in the art that the following examples are only used to illustrate the present application and should not be considered as limiting the scope of the present application. In the examples, if specific conditions are not specified, they are carried out according to conventional conditions or the conditions recommended by the manufacturer. The reagents or instruments used are not specified by the manufacturer and are conventional products that can be purchased commercially. The emulsifier was purchased from Nanjing Kehong Chemical Co., Ltd. and the model number is emulsifier 8801.

[0034] In the following examples, 1 portion means 100 g.

[0035] Preparation Example 1 Preparation of Mesosulfuron

[0036] The preparation method of mesosulfuron-methyl comprises the following steps:

[0037] S21, 700g of dichloromethane and 35g of bis(trichloromethyl)carbonate were added to a dry reaction flask, and the mixture was stirred. After the bis(trichloromethyl)carbonate was dissolved, the solution was cooled to 3°C, and a pyrimidineamine solution (the pyrimidineamine solution was prepared by dissolving 35g of pyrimidineamine in 100g of dichloromethane) was added dropwise to the bis(trichloromethyl)carbonate solution. After the addition, the mixture was stirred for 35min, and then 100g of triethylamine was added dropwise. After the addition, the mixture was stirred for 1h to obtain a solution A for standby use; the temperature was controlled to be below 45°C during the reaction;

[0038] S22. Add 69 g of 5-methanesulfonylaminomethyl-2-methoxycarbonylbenzenesulfonamide and 150 g of dichloromethane to another dry reaction flask, cool to 3°C, and slowly add Solution A with stirring. The reaction is exothermic. Control the addition rate of Solution A so that the system temperature does not exceed 30°C.

[0039] S23. After adding solution A, continue stirring for 3 hours, add 1 L of deionized water, stir thoroughly, let stand to separate the layers, separate the organic phase, acidify the aqueous phase with 0.1 L of 2M hydrochloric acid, filter the precipitated solid, and dry to obtain methyldisulfonyl with a purity of 99.5%. Example 1

[0040] A herbicidal composition containing mesosulfuron is prepared from the following components in percentage by mass: 1% mesosulfuron, 18% emulsifier 8801, 3% safener, 2.7% stabilizer, 1% organobentonite, 2% white carbon black, 3% surfactant, and first-grade soybean salad oil (complemented to 100%), wherein the stabilizer is prepared by mixing triphenyl phenol polyether ammonium sulfate, naphthalenesulfonate formaldehyde condensate, and diatomaceous earth in a mass ratio of 5:7:15, the diatomaceous earth has an average particle size of 5.2 μm, the white carbon black has an average particle size of 5 microns, and the organobentonite has an average particle size of 325 meshes; the safener is 5-aminolevulinic acid; and the surfactant is prepared by mixing lauryl alcohol polyethylene glycol ether acetal, alkylphenol polyoxyethylene ether phosphate, and alkyl polyoxyethylene ether sulfonate in a mass ratio of 5:4:4; the mesosulfuron is the mesosulfuron prepared in Preparation Example 1;

[0041] The preparation method of the above-mentioned herbicidal composition containing mesosulfuron comprises the following steps: according to the formulated amount, mesosulfuron, emulsifier 8801, safener, stabilizer, organic bentonite, white carbon black, surfactant and first-grade soybean salad oil are mixed and stirred uniformly to obtain the herbicidal composition containing mesosulfuron. Example 2

[0042] A herbicidal composition containing mesosulfuron is prepared from the following components by mass percentage: 1% mesosulfuron, 18% emulsifier 8801, 3% safener, 2.7% stabilizer, 3% organobentonite, 3% white carbon black, 3.5% surfactant, and first-grade soybean salad oil (complemented to 100%), wherein the stabilizer is prepared by mixing triphenyl phenol polyether ammonium sulfate, naphthalenesulfonate formaldehyde condensate, and diatomaceous earth in a mass ratio of 5:7:15, the diatomaceous earth has an average particle size of 5.2 μm, the white carbon black has an average particle size of 5 microns, and the organobentonite has an average particle size of 325 meshes; the safener is ethyl 5-phenyl-4,5-dihydroisoxazole-3-carboxylate; the surfactant is prepared by mixing lauryl alcohol polyethylene glycol ether acetal, alkylphenol polyoxyethylene ether phosphate, and alkyl polyoxyethylene ether sulfonate in a mass ratio of 5:4:4; and the mesosulfuron is the mesosulfuron prepared in Preparation Example 1.

[0043] The preparation method of the above-mentioned herbicidal composition containing mesosulfuron comprises the following steps: according to the formulated amount, mesosulfuron, emulsifier 8801, safener, stabilizer, organic bentonite, white carbon black, surfactant and first-grade soybean salad oil are mixed and stirred uniformly to obtain the herbicidal composition containing mesosulfuron. Example 3

[0044] A herbicidal composition containing mesosulfuron-butyl is prepared from the following components by mass percentage: 1% mesosulfuron-butyl, 18% emulsifier 8801, 3% safener, 2.7% stabilizer, 2% organobentonite, 2.5% white carbon black, 3.4% surfactant, and first-grade soybean salad oil (complemented to 100%), wherein the stabilizer is prepared by mixing triphenyl phenol polyether ammonium sulfate, naphthalenesulfonate formaldehyde condensate, and diatomaceous earth in a mass ratio of 5:7:15, the diatomaceous earth has an average particle size of 5.2 μm, the white carbon black has an average particle size of 5 microns, and the organobentonite has an average particle size of 325 mesh; the safener is mefenpyr-butyl; the surfactant is prepared by mixing lauryl alcohol polyethylene glycol ether acetal, alkylphenol polyoxyethylene ether phosphate, and alkyl polyoxyethylene ether sulfonate in a mass ratio of 5:4:4; the mesosulfuron-butyl is the mesosulfuron-butyl prepared in Preparation Example 1;

[0045] The preparation method of the above-mentioned herbicidal composition containing mesosulfuron comprises the following steps: according to the formulated amount, mesosulfuron, emulsifier 8801, safener, stabilizer, organic bentonite, white carbon black, surfactant and first-grade soybean salad oil are mixed and stirred uniformly to obtain the herbicidal composition containing mesosulfuron. Example 4

[0046] The method is the same as Example 3, except that the safener is prepared by mixing mefenpyr-butyl, ethyl 5-phenyl-4,5-dihydroisoxazole-3-carboxylate and 5-aminolevulinic acid in a mass ratio of 3:4:3.

[0047] Comparative Example 1

[0048] The same as Example 4, except that the mesosulfuron-methyl was purchased from Hubei Kewode Chemical Co., Ltd. (CAS: 208465-21-8, purity 95%).

[0049] Comparative Example 2

[0050] The method is the same as Example 4, except that the stabilizer is prepared by mixing triphenethylphenol polyether ammonium sulfate and diatomaceous earth in a mass ratio of 12:15.

[0051] Comparative Example 3

[0052] The method is the same as Example 4, except that the stabilizer is prepared by mixing naphthalenesulfonate formaldehyde condensate and diatomaceous earth in a mass ratio of 12:15.

[0053] Comparative Example 4

[0054] The same as Example 4, except that the surfactant is lauryl alcohol polyethylene glycol ether acetal.

[0055] Comparative Example 5

[0056] The same as Example 4, except that the surfactant is alkylphenol polyoxyethylene ether phosphate.

[0057] Comparative Example 6

[0058] The same as Example 4, except that the surfactant is alkyl polyoxyethylene ether sulfonate.

[0059] Performance test: Experiment on the effect of controlling weeds in wheat fields

[0060] Refer to "Guidelines for Field Efficacy Tests of Pesticides (I) Herbicides for Control of Weeds in Wheat Crops" (GB / T17980.41-2000).

[0061] The test site was Liangjiawu Village, Panggezhuang Town, Daxing District, Beijing. The wheat fields were flat and sandy loam with medium fertility. The experimental crop was winter wheat, Nongda 211 variety, and the previous crop was rice.

[0062] Test targets: Common weeds in wheat fields, mainly including Alopecurus mume, Hard grass, Chickweed, Chickweed, Shepherd's purse, Artemisia selengensis, Cyperus diversifolia, etc.

[0063] Experimental Design: A total of 11 treatments were set up in the experiment, corresponding to the herbicidal compositions containing mesosulfuron prepared in Examples 1 to 4 and Comparative Examples 1 to 6 and water (control area). All experimental plots were arranged in random blocks, with a plot area of ​​40 m 2 , each treatment was repeated 4 times.

[0064] Application time: The test was carried out by spraying the stems and leaves when the weeds were in the 3rd and 4th stages. The application equipment was a 3WBD backpack electric sprayer with a spray pressure of 0.5 MPa. The dosage of the herbicidal composition containing methyl disulfone was 90 mL per mu, and it was diluted with 10 L of water before spraying.

[0065] Test investigation method: Wheat damage was observed 15 days and 30 days after application. Safety investigation: Each test plot was graded and scored according to the damage grading method: Level 1, normal crop growth, no symptoms of damage; Level 2, slight crop damage, less than 3% of the crops; Level 3, moderate crop damage, which can be recovered later and has no impact on yield; Level 4, severe crop damage, difficult to recover, resulting in reduced yield; Level 5, severe crop damage, irrecoverable, resulting in significant yield reduction or total loss; Using the absolute value investigation method, samples were randomly collected at 4 points in each test plot 15 days, 30 days, and 45 days after application, with a depth of 0.25 m at each point. 2 The plant protection efficacy in each experimental plot was investigated, and the fresh weight was measured 45 days after the application of the drug to calculate the fresh weight protection efficacy.

[0066] Calculation method:

[0067]

[0068]

[0069] The test results are shown in Table 1.

[0070] Wheat yield: After wheat matured, the number of ears was surveyed in each experimental plot, the wheat was threshed and the yield was measured, and the thousand-grain weight was measured. The test results are shown in Table 1.

[0071] Table 1 Test results and yield of weed control effect on wheat fields

[0072]

[0073] Analyzing the data in Table 1, we can see that:

[0074] 1) The herbicidal compositions containing mesosulfuron prepared in Examples 1 to 4 not only have good weed control effects and reduce the dosage of the agent, but are also safe for wheat and have no effect on subsequent crops. They are ideal herbicides with broad application prospects and can also improve wheat yield and quality.

[0075] 2) A comparative analysis of the performance of the herbicidal compositions containing mesosulfuron prepared in combination with Examples 4 and 1-3 shows that the safener is prepared by mixing pyraclostrobin, ethyl 5-phenyl-4,5-dihydroisoxazole-3-carboxylate, and 5-aminolevulinic acid in a mass ratio of 3:4:3. The synergistic effect between these three compounds can further enhance the weed control effect of mesosulfuron: pyraclostrobin, ethyl 5-phenyl-4,5-dihydroisoxazole-3-carboxylate, and 5-aminolevulinic acid all have the effect of enhancing plant resistance, which can enhance the weed control effect of mesosulfuron. Reduce the hidden danger of phytotoxicity to wheat: pyraclostrobin, ethyl 5-phenyl-4,5-dihydroisoxazole-3-carboxylate, and 5-aminolevulinic acid all have the ability to protect plants from drug damage, which can reduce the hidden danger of phytotoxicity to wheat caused by mesosulfuron. Improving wheat safety, yield, and quality: Mepyralid, ethyl 5-phenyl-4,5-dihydroisoxazole-3-carboxylate, and 5-aminolevulinic acid all promote plant growth and development, and can improve wheat safety, yield, and quality. In summary, the safener is prepared by mixing mepyralid, ethyl 5-phenyl-4,5-dihydroisoxazole-3-carboxylate, and 5-aminolevulinic acid in a mass ratio of 3:4:3. It can significantly enhance the weed control effect of mesosulfuron-methyl, reduce the risk of phytotoxicity to wheat, and improve wheat safety, yield, and quality.

[0076] 3) A comparative analysis of the performance of the herbicidal compositions containing mesosulfuron prepared in Example 3 and Comparative Example 1 shows that the high-purity mesosulfuron prepared in this application is a highly effective herbicide with excellent control effect on resistant weeds, and is superior to mesosulfuron on the market.

[0077] 4) A comparative analysis of the performance of the herbicidal compositions containing mesosulfuron-methyl prepared in combination with Example 3 and Comparative Examples 2-3 showed that the stabilizer was prepared by mixing triphenylphenol polyether ammonium sulfate, naphthalenesulfonate formaldehyde condensate, and diatomaceous earth in a mass ratio of 5:7:15. The synergistic effect between triphenylphenol polyether ammonium sulfate and naphthalenesulfonate formaldehyde condensate significantly improved the weed control efficacy of the herbicidal composition, the safety of wheat, and the yield of wheat.

[0078] 5) A comparative analysis of the performance of the herbicidal compositions containing mesosulfuron prepared in combination with Example 3 and Comparative Examples 4 to 6 shows that the surfactant is prepared by mixing lauryl alcohol polyethylene glycol ether acetal, alkylphenol polyoxyethylene ether phosphate and alkyl polyoxyethylene ether sulfonate in a mass ratio of 5:4:4. The surfactant plays a vital role in the herbicidal composition containing mesosulfuron because it can improve the adhesion and conductivity of mesosulfuron on the leaves of weeds. Through this improvement, mesosulfuron can better adhere to the leaves and stems of weeds, thereby improving its control effect on weeds. In addition, the surfactant can also improve the safety of wheat and reduce the potential damage of the agent to wheat. By utilizing the synergistic effect between these three surfactants, the herbicidal composition containing mesosulfuron prepared in this application not only has a good control effect on resistant weeds, reduces the dosage of the agent, but also has good safety for wheat and has no effect on subsequent crops. It is an ideal herbicide with broad application prospects.

[0079] The above embodiments are only used to illustrate the technical solutions of the present application and are not intended to limit the present application. Although the above embodiments provide a detailed description of the present application, relevant technical personnel should understand that the specific implementation methods of the present invention can still be modified or replaced by equivalents. Any modifications and equivalent replacements that do not depart from the spirit and scope of the present application should be included in the scope of protection of the present application.

Claims

1. A herbicidal composition containing mesosulfuron, characterized in that: The invention is prepared from the following components by mass percentage: 1% mesosulfuron-methyl, 18% emulsifier, 3% safener, 2.7% stabilizer, 1-3% organic bentonite, 2-3% white carbon black, 3-3.5% surfactant, and first-grade soybean salad oil to 100%, wherein the stabilizer is prepared by mixing triphenyl phenol polyether ammonium sulfate, naphthalenesulfonate formaldehyde condensate, and diatomaceous earth in a mass ratio of 5:7:15, and the average particle size of the diatomaceous earth is 5.2 μm; the safener is prepared by mixing mefenpyr, ethyl 5-phenyl-4,5-dihydroisoxazole-3-carboxylate, and 5-aminolevulinic acid in a mass ratio of 3:4:3; The surfactant is prepared by mixing lauryl alcohol polyethylene glycol ether acetal, alkylphenol polyoxyethylene ether phosphate and alkyl polyoxyethylene ether sulfonate in a mass ratio of 5:4:4; The preparation method of mesosulfuron-methyl comprises the following steps: S21, 700g of dichloromethane and 35g of bis(trichloromethyl)carbonate were added to a dry reaction flask and stirred. After the bis(trichloromethyl)carbonate was dissolved, the solution was cooled to 3°C, and the pyrimidineamine solution was added dropwise to the bis(trichloromethyl)carbonate solution. After the addition, the mixture was stirred for 35min. Then, 100g of triethylamine was added dropwise and stirred for 1h to obtain a solution A for standby use. The temperature was controlled to be lower than 45°C during the reaction. The pyrimidineamine solution was prepared by dissolving 35g of pyrimidineamine in 100g of dichloromethane. S22. Add 69 g of 5-methanesulfonylaminomethyl-2-methoxycarbonylbenzenesulfonamide and 150 g of dichloromethane to another dry reaction flask, cool to 3°C, and slowly add Solution A with stirring. The reaction is exothermic, and the addition rate of Solution A is controlled so that the system temperature does not exceed 30°C. S23. After adding solution A, continue stirring for 3 hours, add 1 L of deionized water, stir thoroughly, let stand to separate the layers, separate the organic phase, acidify the aqueous phase with 0.1 L of 2M hydrochloric acid, filter the precipitated solid, and dry to obtain methyldisulfonyl with a purity of 99.5%.

2. A herbicidal composition containing mesosulfuron-methyl according to claim 1, characterized in that: The emulsifier is emulsifier 8801 produced by Nanjing Kehong Chemical Co., Ltd.

3. A herbicidal composition containing mesosulfuron-methyl according to claim 1, characterized in that: The average particle size of the white carbon black is 5 microns, and the average particle size of the organic bentonite is 325 meshes.

4. A method for preparing a herbicidal composition containing mesosulfuron-methyl according to any one of claims 1 to 3, characterized in that: The following steps are involved: According to the dosage of the formula, mesosulfuron, emulsifier, safener, stabilizer, organic bentonite, white carbon black, surfactant and first-grade soybean salad oil are mixed and stirred evenly to obtain a herbicidal composition containing mesosulfuron.

5. Use of a herbicidal composition containing mesosulfuron-methyl according to any one of claims 1 to 3 for controlling annual weeds in winter wheat fields, characterized in that: Use stem and leaf spraying method, with a dosage of 60-100mL per mu.

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