Preparation process of medical liquid repair dressing

Abstract

The invention relates to the field of preparation of medical dressings, in particular to a preparation process of a medical liquid repair dressing. According to the technical scheme, the dressing is prepared from the following components in percentage by mass: 2.5 to 5 percent of onion extract, 0.5 to 2.5 percent of saffron crocus extract, 0.25 to 1.5 percent of chamomile essential oil, 0.05 to 0.5 percent of allantoin, 0.5 to 1 percent of seaweed gel, 0.5 to 1 percent of carrageenan, 0.03 to 0.5 percent of hydrolyzed collagen, 0.02 to 0.5 percent of hyaluronic acid, 1 to 2 percent of humectant, 0.5 to 2.5 percent of polyvinyl alcohol, 0.1 to 1 percent of glutaraldehyde and 92 to 95 percent of deionized water. The medical liquid repair dressing has the beneficial effects that the polyvinyl alcohol is added into the medical liquid repair dressing, and the polyvinyl alcohol is a modifier with high initial adhesion, so that the initial surface adhesion of the medical liquid repair dressing can be enhanced, and the adhesion is gradually lost after water evaporation; when water in the medical liquid repair dressing is evaporated and needs to be torn down for replacement, adhesion between the surface of the repair dressing and the surface of a wound is reduced, and discomfort of a patient is reduced.

Description

Technical Field

[0001] The invention relates to the field of medical dressing preparation, and in particular to a preparation process of a medical liquid repair dressing. Background Art

[0002] The skin is the first barrier between the body and nature, and it can prevent the invasion of pathogenic microorganisms from the environment and the loss of body fluids. The skin is a very important organ in the body, but skin trauma is also very common in life, especially scalds and burns, which not only cause skin damage and defects, but also leave ugly scars after the trauma.

[0003] The use of medical liquid repair dressings for scalds and burns can effectively promote wound healing. It is usually made of biocompatible materials and can provide a moist environment to help accelerate cell regeneration and repair. The dressing is suitable for various types of wounds, such as postoperative wounds, burns or trauma.

[0004] The existing technology has the following deficiencies: as patients' requirements increase, the requirements for skin repair agents are also getting higher and higher, requiring not only to achieve significant treatment or recovery effects, but also to have little irritation to the skin during use; the existing liquid repair dressings often use a repair dressing with a hydrogel as the base material. When there are some tiny secretions or liquids on the skin around the wound, the hydrogel base material may produce a certain adhesion to the wound surface during a slight tearing process, which may cause the tissue on the wound surface to be pulled, thereby causing discomfort and adhesion. For wounds that are healing, especially when the surface tissue begins to form a new cell layer, it may also cause tearing, resulting in pain or bleeding.

[0005] Therefore, it is necessary to invent a preparation process for medical liquid repair dressing. Summary of the invention

[0006] In order to achieve the above-mentioned object, the present invention provides the following technical scheme: a preparation process of a medical liquid repair dressing, the dressing comprising the following components in mass percentage: 2.5-5% onion extract, 0.5-2.5% saffron extract, 0.25-1.5% chamomile essential oil, 0.05-0.5% allantoin, 0.5-1% alginate, 0.5-1% carrageenan, 0.03-0.5% hydrolyzed collagen, 0.02-0.5% hyaluronic acid, 1-2% moisturizer, 0.5-2.5% polyvinyl alcohol, 0.1-1% glutaraldehyde, 92-95% deionized water,

[0007] Step 1, under a sterile environment, 0.05-0.5% allantoin, 0.5-1% alginate, 0.5-1% carrageenan, 0.03-0.5% hydrolyzed collagen, and 0.02-0.5% hyaluronic acid are sequentially added into a stirring container, and the stirrer is turned on, maintained at a fixed speed, and stirred for 10-20 minutes to prepare a mixture 1;

[0008] Step 2: Add 92-95% deionized water to the mixture 1 obtained in step 1 to dissolve it, then add 1-2% moisturizer, the moisturizer is glycerol or 1.3-propylene glycol, stir and heat to 80° C. until the mixture is fully dissolved to obtain a mixed solution 1;

[0009] Step 3, add 0.5-2.5% polyvinyl alcohol to the mixed solution 1 prepared in step 2, heat it to 90° C., then add 0.1-1% glutaraldehyde and stir until fully dissolved to obtain a mixed solution 2;

[0010] Step 4, cooling the mixed solution 2 obtained in step 3 to 70°C and keeping it warm for 20 to 40 minutes, then adding 2.5 to 5% onion extract, 0.5 to 2.5% saffron extract, and 0.25 to 1.5% chamomile essential oil in sequence, stirring until fully dissolved, to obtain a mixed solution 3; the preparation method of the onion extract is: chopping the onion, freeze-drying it to a weight moisture content of 5% to 15%, and then extracting it with a 10% to 50% volume concentration ethanol solution, the extraction temperature is 60 to 70°C, the extraction time is 1 to 10 hours, filtering the extract, and filtering the filter. The liquid is concentrated under reduced pressure to recover ethanol, and the concentrated liquid is spray-dried to obtain onion extract; the preparation method of saffron extract is as follows: after saffron is crushed, it is freeze-dried to a weight moisture content of 5% to 10%, and then it is soaked in n-hexane or cyclohexane for 12 to 24 hours, and the solid-liquid ratio is 1kg / 1 to 10L, filtered, and the filter residue is extracted with an ethanol solution with a volume concentration of 50% to 95%, the extraction temperature is 50 to 60°C, the extraction time is 0.5 to 5h, filtered, the filtrate is concentrated under reduced pressure to recover ethanol, and the concentrated liquid is spray-dried to obtain saffron extract;

[0011] Step 5: cancel the heat preservation of the mixed solution 3 in step 4, then use ultrasound with a frequency of 20kHz to 40kHz to perform ultrasonic defoaming on the mixed solution 3 for 5 to 20 minutes, then pour it into the mold and make it evenly distributed in the mold, let it stand for 15 to 30 minutes, and after the dressing is formed, encapsulate it to make a highly transparent skin repair hydrogel dressing.

[0012] The beneficial effects of the present invention are as follows: the medical liquid repair dressing of the present invention is added with polyvinyl alcohol, which is a modifier with high initial adhesion, and can enhance the initial surface adhesion of the medical liquid repair dressing, and gradually lose the adhesion after the water evaporates, so as to achieve the effect of reducing the adhesion between the surface of the repair dressing and the wound surface when the water of the medical liquid repair dressing evaporates and needs to be torn off and replaced, relieving the traction on the tissue on the wound surface, reducing the patient's discomfort, and avoiding tearing that causes wound pain or bleeding. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 A comparison chart of the adhesion coefficient between a repair dressing and a wound surface in a preparation process of a medical liquid repair dressing provided by the present invention. DETAILED DESCRIPTION

[0014] The preferred embodiments of the present invention are described below in conjunction with the accompanying drawings. It should be understood that the preferred embodiments described herein are only used to illustrate and explain the present invention, and are not used to limit the present invention.

[0015] Example 1

[0016] A preparation process of a medical liquid repair dressing in an embodiment of the first aspect of the present invention, the dressing comprises the following components in percentage by mass: 2.5% onion extract, 0.5% saffron extract, 0.25% chamomile essential oil, 0.05% allantoin, 0.5% alginate, 0.5% carrageenan, 0.03% hydrolyzed collagen, 0.02% hyaluronic acid, 1% moisturizer, 0.5% polyvinyl alcohol, 0.1% glutaraldehyde, 92% deionized water,

[0017] Step 1: In a sterile environment, 0.05% allantoin, 0.5% alginate, 0.5% carrageenan, 0.03% hydrolyzed collagen, and 0.02% hyaluronic acid are sequentially added into a stirring container, and the stirrer is turned on, maintained at a fixed speed, and stirred for 10 to 20 minutes to prepare a mixture 1;

[0018] Step 2: Add 92% deionized water to the mixture 1 obtained in step 1 to dissolve it, then add 1% moisturizer, the moisturizer is glycerol or 1.3-propylene glycol, stir and heat to 80° C. until the mixture is fully dissolved to obtain a mixed solution 1;

[0019] Step 3, add 0.5% polyvinyl alcohol to the mixed solution 1 prepared in step 2, heat it to 90° C., then add 0.1% glutaraldehyde and stir until fully dissolved to obtain a mixed solution 2;

[0020] Step 4: Cool the mixed solution 2 obtained in step 3 to 70° C. and keep it warm for 20 to 40 minutes, then add 2.5% onion extract, 0.5% saffron extract, and 0.25% chamomile essential oil in sequence, and stir until fully dissolved to obtain a mixed solution 3; the preparation method of the onion extract is: chop the onion, freeze-dry it to a weight moisture content of 5% to 15%, and then extract it with an ethanol solution with a volume concentration of 10% to 50%, the extraction temperature is 60 to 70° C., the extraction time is 1 to 10 hours, the extract is filtered, and the filtrate is concentrated under reduced pressure Recover ethanol, spray-dry the obtained concentrated solution, and obtain onion extract; the preparation method of saffron extract is as follows: crush saffron, freeze-dry it to a weight moisture content of 5% to 10%, and then soak it in n-hexane or cyclohexane for 12 to 24 hours, with a solid-liquid ratio of 1kg / 1 to 10L, filter, extract the filter residue with an ethanol solution with a volume concentration of 50% to 95%, the extraction temperature is 50 to 60°C, the extraction time is 0.5 to 5h, filter, decompress and concentrate the filtrate to recover ethanol, and spray-dry the obtained concentrated solution to obtain saffron extract;

[0021] Step 5: cancel the heat preservation of the mixed solution 3 in step 4, then use ultrasound with a frequency of 20kHz to 40kHz to perform ultrasonic defoaming on the mixed solution 3 for 5 to 20 minutes, then pour it into the mold and make it evenly distributed in the mold, let it stand for 15 to 30 minutes, and after the dressing is formed, encapsulate it to make a highly transparent skin repair hydrogel dressing.

[0022] In the above embodiments, it should be noted that when the medical liquid repair dressing prepared in Example 1 is applied to the wound and then torn off after the water evaporates, the adhesion between the surface of the repair dressing and the surface of the wound is relatively severe, the tissue on the surface of the wound is subjected to a strong pulling effect, the patient feels strong discomfort, and is accompanied by wound pain and a small amount of bleeding.

[0023] Example 2

[0024] A preparation process of a medical liquid repair dressing in an embodiment of the second aspect of the present invention, the dressing comprises the following components in percentage by mass: 3.75% onion extract, 1.5% saffron extract, 0.75% chamomile essential oil, 0.3% allantoin, 0.75% alginate, 0.75% carrageenan, 0.3% hydrolyzed collagen, 0.3% hyaluronic acid, 1.5% moisturizer, 1.5% polyvinyl alcohol, 0.5% glutaraldehyde, 93.5% deionized water,

[0025] Step 1: In a sterile environment, 0.3% allantoin, 0.75% alginate, 0.75% carrageenan, 0.3% hydrolyzed collagen, and 0.3% hyaluronic acid are added to a stirring container in sequence, and the stirrer is turned on, maintained at a fixed speed, and stirred for 10 to 20 minutes to prepare a mixture 1;

[0026] Step 2: Add 93.5% deionized water to the mixture 1 obtained in step 1 to dissolve it, then add 1.5% moisturizer, the moisturizer is glycerol or 1.3-propylene glycol, stir and heat to 80° C. until the mixture is fully dissolved to obtain a mixed solution 1;

[0027] Step 3, add 1.5% polyvinyl alcohol to the mixed solution 1 prepared in step 2, heat it to 90° C., then add 0.5% glutaraldehyde and stir until fully dissolved to obtain a mixed solution 2;

[0028] Step 4: Cool the mixed solution 2 obtained in step 3 to 70° C. and keep it warm for 20 to 40 minutes, then add 3.75% onion extract, 1.5% saffron extract, and 0.75% chamomile essential oil in sequence, and stir until fully dissolved to obtain a mixed solution 3; the preparation method of the onion extract is: chop the onion, freeze-dry it to a weight moisture content of 5% to 15%, and then extract it with a 10% to 50% volume concentration ethanol solution, the extraction temperature is 60 to 70° C., the extraction time is 1 to 10 hours, the extract is filtered, and the filtrate is concentrated under reduced pressure Recover ethanol, spray-dry the obtained concentrated solution, and obtain onion extract; the preparation method of saffron extract is as follows: crush saffron, freeze-dry it to a weight moisture content of 5% to 10%, and then soak it in n-hexane or cyclohexane for 12 to 24 hours, with a solid-liquid ratio of 1kg / 1 to 10L, filter, extract the filter residue with an ethanol solution with a volume concentration of 50% to 95%, the extraction temperature is 50 to 60°C, the extraction time is 0.5 to 5h, filter, decompress and concentrate the filtrate to recover ethanol, and spray-dry the obtained concentrated solution to obtain saffron extract;

[0029] Step 5: cancel the heat preservation of the mixed solution 3 in step 4, then use ultrasound with a frequency of 20kHz to 40kHz to perform ultrasonic defoaming on the mixed solution 3 for 5 to 20 minutes, then pour it into the mold and make it evenly distributed in the mold, let it stand for 15 to 30 minutes, and after the dressing is formed, encapsulate it to make a highly transparent skin repair hydrogel dressing.

[0030] In the above embodiments, it should be noted that the medical liquid repair dressing prepared in Example 2 is applied to the wound and torn off after the water evaporates. The adhesion between the surface of the repair dressing and the surface of the wound is relatively light, and the pulling effect on the tissue on the surface of the wound is relatively weak. The patient does not feel any discomfort, the pain of the wound is relatively weak, and no bleeding occurs.

[0031] Example 3

[0032] A preparation process of a medical liquid repair dressing in an embodiment of the third aspect of the present invention, the dressing comprises the following components in percentage by mass: 5% onion extract, 2.5% saffron extract, 0.25% chamomile essential oil, 5% onion extract, 2.5% saffron extract, 1.5% chamomile essential oil, 0.5% allantoin, 1% alginate, 1% carrageenan, 0.5% hydrolyzed collagen, 0.5% hyaluronic acid, 2% moisturizer, 2.5% polyvinyl alcohol, 1% glutaraldehyde, 95% deionized water,

[0033] Step 1: In a sterile environment, 0.5% allantoin, 1% alginate, 1% carrageenan, 0.5% hydrolyzed collagen, and 0.5% hyaluronic acid are added to a stirring container in sequence, and the stirrer is turned on, maintained at a fixed speed, and stirred for 10 to 20 minutes to prepare a mixture 1;

[0034] Step 2: Add 95% deionized water to the mixture 1 obtained in step 1 to dissolve it, then add 2% moisturizer, the moisturizer is glycerol or 1.3-propylene glycol, stir and heat to 80° C. until the mixture is fully dissolved to obtain a mixed solution 1;

[0035] Step 3, add 2.5% polyvinyl alcohol to the mixed solution 1 prepared in step 2, heat it to 90° C., then add 1% glutaraldehyde and stir until fully dissolved to obtain a mixed solution 2;

[0036] Step 4, cooling the mixed solution 2 obtained in step 3 to 70°C and keeping it warm for 20 to 40 minutes, then adding 5% onion extract, 2.5% saffron extract, and 1.5% chamomile essential oil in sequence, stirring until fully dissolved, to obtain a mixed solution 3; the preparation method of the onion extract is: chopping the onion, freeze-drying it to a weight moisture content of 5% to 15%, then extracting it with an ethanol solution with a volume concentration of 10% to 50%, the extraction temperature is 60 to 70°C, the extraction time is 1 to 10 hours, filtering the extract, and concentrating the filtrate under reduced pressure to recover ethanol, and the obtained concentrated solution is spray-dried to obtain onion extract; the preparation method of saffron extract is as follows: after saffron is crushed, freeze-dried to a weight moisture content of between 5% and 10%, and then soaked in n-hexane or cyclohexane for 12 to 24 hours, with a solid-liquid ratio of 1kg / 1 to 10L, filtered, and the residue is extracted with an ethanol solution with a volume concentration of 50% to 95%, the extraction temperature is 50 to 60°C, the extraction time is 0.5 to 5h, filtered, the filtrate is concentrated under reduced pressure to recover ethanol, and the obtained concentrated solution is spray-dried to obtain saffron extract;

[0037] Step 5: cancel the heat preservation of the mixed solution 3 in step 4, then use ultrasound with a frequency of 20kHz to 40kHz to perform ultrasonic defoaming on the mixed solution 3 for 5 to 20 minutes, then pour it into the mold and make it evenly distributed in the mold, let it stand for 15 to 30 minutes, and after the dressing is formed, encapsulate it to make a highly transparent skin repair hydrogel dressing.

[0038] In the above embodiments, it should be noted that the medical liquid repair dressing prepared in Example 3 is applied to the wound and torn off after the water evaporates. The surface of the repair dressing is moderately adhered to the surface of the wound, and the tissue on the surface of the wound is significantly stretched. The patient has a slight discomfort, accompanied by slight pain and redness and swelling of the wound.

[0039] like Figure 1 As shown, by comparing Example 1, Example 2, and Example 3, it can be concluded that the medical liquid repair dressing prepared by the component ratio adopted in Example 2 has the best use effect. When it is applied to the wound and torn off after the water evaporates, the degree of adhesion is relatively light and the patient does not feel any discomfort.

[0040] The above is only a preferred embodiment of the present invention. Any person skilled in the art may modify the present invention by using the above technical solution or modify it into an equivalent technical solution. Therefore, any simple modification or equivalent replacement made according to the technical solution of the present invention shall fall within the scope of protection claimed by the present invention.

Claims

1. A preparation process of a medical liquid repair dressing, characterized in that: The dressing comprises the following components in percentage by mass: 2.5-5% onion extract, 0.5-2.5% saffron extract, 0.25-1.5% chamomile essential oil, 0.05-0.5% allantoin, 0.5-1% alginate, 0.5-1% carrageenan, 0.03-0.5% hydrolyzed collagen, 0.02-0.5% hyaluronic acid, 1-2% moisturizer, 0.5-2.5% polyvinyl alcohol, 0.1%-1% glutaraldehyde, and 92%-95% deionized water. Step 1, in a sterile environment, 0.05-0.5% allantoin, 0.5-1% alginate, 0.5-1% carrageenan, 0.03-0.5% hydrolyzed collagen, and 0.02-0.5% hyaluronic acid are sequentially mixed to prepare a mixture 1; Step 2: Add 92% to 95% deionized water to the mixture 1 obtained in step 1 to dissolve it, then add 1 to 2% moisturizer, stir and heat to 80° C. until the mixture is fully dissolved to obtain a mixed solution 1; Step 3, add 0.5-2.5% polyvinyl alcohol to the mixed solution 1 prepared in step 2, heat it to 90° C., then add 0.1%-1% glutaraldehyde and stir until fully dissolved to obtain a mixed solution 2; Step 4, cooling the mixed solution 2 obtained in step 3 to 70° C. and then keeping the mixture warm, then sequentially adding 2.5-5% onion extract, 0.5-2.5% saffron extract, and 0.25-1.5% chamomile essential oil, stirring until fully dissolved, to obtain a mixed solution 3; Step 5: cancel the heat preservation of the mixed solution 3 in step 4, then ultrasonically defoam the mixed solution 3, and then pour it into the mold and evenly distribute it in the mold, let it stand, and after the dressing is formed, encapsulate it to make a highly transparent skin repair hydrogel dressing.

2. The preparation process of a medical liquid repair dressing according to claim 1, characterized in that: The mixture 1 in the step 1 is stirred using a stirrer or a high shear mixer, and allantoin, alginate, carrageenan, hydrolyzed collagen, and hyaluronic acid are added to a stirring container in a certain proportion, and the stirrer is turned on and maintained at a fixed speed until the mixture is evenly mixed, and the stirring time is 10 to 20 minutes.

3. The preparation process of a medical liquid repair dressing according to claim 1, characterized in that: The moisturizing agent in step 2 is one of glycerol and 1.3-propylene glycol.

4. The preparation process of a medical liquid repair dressing according to claim 1, characterized in that: The mixed solution 2 in step 4 is cooled to 70° C. and then kept warm for 20 to 40 minutes.

5. The preparation process of a medical liquid repair dressing according to claim 1, characterized in that: The preparation method of the onion extract in step 4 is as follows: chop the onion, freeze-dry it to a weight moisture content of 5% to 15%, then extract it with an ethanol solution with a volume concentration of 10% to 50%, the extraction temperature is 60 to 70° C., the extraction time is 1 to 10 hours, the extract is filtered, the filtrate is concentrated under reduced pressure to recover ethanol, and the concentrated solution is spray-dried to obtain the onion extract.

6. The preparation process of a medical liquid repair dressing according to claim 1, characterized in that: The preparation method of the saffron extract in the step 4 is as follows: crush the saffron, freeze-dry it to a weight moisture content of 5% to 10%, then soak it in n-hexane or cyclohexane for 12 to 24 hours, with a solid-liquid ratio of 1kg / 1 to 10L, filter it, extract the filter residue with an ethanol solution with a volume concentration of 50% to 95%, the extraction temperature is 50 to 60°C, the extraction time is 0.5 to 5h, filter it, concentrate the filtrate under reduced pressure to recover ethanol, and spray-dry the obtained concentrated solution to obtain the saffron extract.

7. The preparation process of a medical liquid repair dressing according to claim 1, characterized in that: The ultrasonic defoaming of the mixed solution 3 in step 5 uses an ultrasonic frequency of 20kHz to 40kHz, and the ultrasonic working time is determined according to the size and number of bubbles, and is 5 to 20 minutes.

8. The preparation process of a medical liquid repair dressing according to claim 1, characterized in that: The standing time in step 5 is 15 to 30 minutes.

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