Sleep quality and appetite improving composition and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine compositions, and particularly discloses a sleep quality and appetite improving composition and a preparation method thereof.The composition is prepared from, by weight, 20-30 parts of spina date seeds, 8-10 parts of poria cocos, 6-10 parts of rhizoma anemarrhenae, 10-12 parts of ligusticum wallichii, 8-10 parts of liquorice and 1-5 parts of olanzapine. The effects of improving the sleep quality and promoting appetite are remarkably improved, and the side effects such as sleepiness, dizziness and weight gain possibly caused when olanzapine is independently used are effectively relieved in the composition. The traditional Chinese medicinal materials are added, so that the medicine property can be regulated, the adverse reaction of olanzapine can be relieved, the overall medicine property of the composition is more mild, the composition is suitable for wider crowds, and the use safety of the medicine is improved.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a composition for improving sleep quality and appetite and a preparation method thereof. Background Art

[0002] In modern society, with the accelerated pace of life and increased work pressure, more and more people are facing problems with poor sleep quality and appetite. These problems not only affect individuals' daily life and work efficiency, but may also have long-term adverse effects on physical health.

[0003] Traditional Chinese medicine has a long history and rich experience in regulating human physiological functions, improving sleep quality and promoting appetite. Chinese medicinal materials such as Ziziphus jujuba, Poria, Rhizoma Anemarrhenae, Rhizoma Chuanxiong and Licorice are widely believed to have the effects of calming the nerves, strengthening the spleen and stimulating appetite, and are commonly used medicines to improve sleep and appetite. However, the traditional use of these Chinese medicinal materials often has the disadvantages of slow efficacy, short-lasting effect and poor taste, which limits their widespread application in the modern medical system. On the other hand, olanzapine, as a Western medicine ingredient, has been proven to have significant effects on improving sleep quality and regulating appetite. However, the use of olanzapine alone may also bring a series of side effects, such as drowsiness, dizziness, weight gain, etc., which affects the extensiveness and safety of its clinical application.

[0004] However, there is currently a lack of pharmaceutical compositions that combine the advantages of Chinese and Western medicines to effectively improve sleep quality and appetite while reducing side effects. The existing ones cannot meet the urgent needs of modern people for improving sleep quality and appetite. Summary of the invention

[0005] The object of the present invention is to provide a composition for improving sleep quality and appetite and a preparation method thereof, so as to solve the problems raised in the above background technology.

[0006] To achieve the above object, the present invention provides the following technical solutions:

[0007] A composition for improving sleep quality and appetite comprises the following raw materials in parts by weight: 20-30 parts of spinach seeds, 8-10 parts of tuckahoe, 6-10 parts of rhizoma anemarrhenae, 10-12 parts of rhizoma ligustici, 8-10 parts of liquorice and 1-5 parts of olanzapine.

[0008] Preferably, the composition comprises the following raw materials in parts by weight: 30 parts of Ziziphus jujuba seeds, 10 parts of Poria cocos, 10 parts of Anemarrhena asphodeloides, 12 parts of Ligusticum chuanxiong, 10 parts of Licorice, and 3 parts of olanzapine.

[0009] A method for preparing a composition for improving sleep quality and appetite, comprising the following steps:

[0010] A1. Use a precision electronic scale to weigh the washed and dried Chinese jujube seeds, Poria cocos, Rhizoma Anemarrhenae, Rhizoma Chuanxiong, Glycyrrhizae Radix and olanzapine accurately, and prepare fillers, disintegrants and lubricants; the fillers include but are limited to lactose and starch, the disintegrants include but are limited to sodium carboxymethyl cellulose and cross-linked polyvinylpyrrolidone, and the lubricants include but are not limited to magnesium stearate and talc;

[0011] A2: Use a pulverizer to grind the Chinese medicine raw materials and auxiliary materials in A1 to a size of 280 mesh or more, and then pour the crushed Chinese medicine raw materials into a three-dimensional mixer for 10-30 minutes;

[0012] A3: Add the mixed powder into the dry granulator and make granules through mechanical compression and shearing. The pressure is controlled at 5-20MPa to ensure the compactness and formability of the granules.

[0013] A4: Use a hot air circulation oven, control the temperature between 60-80℃, dry for 1-4 hours, and use a vibrating screen with a mesh size of 280;

[0014] A5: Use a rotary tablet press and control the pressure between 5-20MPa to ensure the hardness and formability of the tablets;

[0015] A6: Check whether the color, shape, surface finish, etc. of the tablets meet the requirements. Use a hardness tester to measure the hardness of the tablets to ensure that they meet the standards. Use high performance liquid chromatography (HPLC) or other appropriate methods to measure the content of each component in the tablets to ensure that they meet the formulation requirements.

[0016] A7: Use packaging materials that meet pharmaceutical standards, such as bags or bottles, to ensure the stability and safety of tablets during storage and transportation.

[0017] Preferably, the method further comprises the following preparation steps: B1, selecting high-quality varieties of Chinese medicinal materials including Semen Ziziphi Spinosae, Poria, Rhizoma Anemarrhenae, Rhizoma Chuanxiong, and Radix Glycyrrhizae without mildew or insect infestation, and olanzapine; and performing strict quality inspection on all raw materials, including but not limited to appearance, smell, and content determination;

[0018] B2. Mix the Chinese medicinal materials of spiny jujube seeds, Poria cocos, Anemarrhena asphodeloides, Ligusticum chuanxiong and Licorice evenly according to the formula ratio, boil them in water at a temperature between 80 and 100°C for at least 2 hours, and control the material-liquid ratio between 1:8 and 1:10;

[0019] B3, pre-treating the extract in B2 by precipitation, filtering the supernatant by microporous membrane, and concentrating by vacuum concentration technology;

[0020] B4, mixing the concentrated liquid medicine with olanzapine powder evenly according to the formula ratio; granulating the mixed liquid medicine by a spray drying granulator;

[0021] B5. Dry the obtained granules to remove excess water; pack and package the dried granules. The packaging materials should meet the requirements of pharmaceutical use to ensure the hygiene and safety of the drugs.

[0022] Compared with the prior art, the present invention has the following beneficial effects:

[0023] The Chinese medicinal materials of Semen Ziziphi Spinosae, Poria, Rhizoma Anemarrhenae, Rhizoma Chuanxiong and Radix Glycyrrhizae in the composition of the present invention each have the effects of calming the nerves, strengthening the spleen and stimulating the appetite, and combined with the sedative and anti-anxiety effects of olanzapine, can act synergistically on the human body, significantly improving the effects of improving sleep quality and promoting appetite, and the side effects of drowsiness, dizziness, weight gain and the like that may be caused by olanzapine when used alone are effectively alleviated in the composition of the present invention. The addition of Chinese medicinal materials can reconcile the medicinal properties and reduce the adverse reactions of olanzapine. The overall medicinal properties of the composition are more peaceful, suitable for a wider range of people, and improve the safety of drug use. DETAILED DESCRIPTION

[0024] The following will be combined with the implementation of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0025] Embodiment 1:

[0026] A composition for improving sleep quality and appetite comprises the following raw materials in parts by weight: 30 parts of spinach seeds, 10 parts of tuckahoe, 10 parts of rhizoma anemarrhenae, 12 parts of ligusticum chuanxiong, 10 parts of liquorice and 3 parts of olanzapine.

[0027] A method for preparing a composition for improving sleep quality and appetite,

[0028] The following steps are involved:

[0029] A1. Use a precision electronic scale to weigh 30 parts of washed and dried Semen Ziziphi Spinosae, 10 parts of Poria cocos, 10 parts of Rhizoma Anemarrhenae, 12 parts of Rhizoma Chuanxiong, 10 parts of Radix Glycyrrhizae, and 3 parts of olanzapine accurately, and prepare fillers, disintegrants, and lubricants; the fillers include but are limited to lactose and starch, the disintegrants include but are limited to sodium carboxymethyl cellulose and cross-linked polyvinylpyrrolidone, and the lubricants include but are not limited to magnesium stearate and talc; wherein olanzapine is 1.25 mg.

[0030] A2: Use a grinder to grind the Chinese medicine raw materials and auxiliary materials in A1 to 300 mesh, and then pour the ground Chinese medicine raw materials into a three-dimensional mixer for 20 minutes;

[0031] A3: Add the mixed powder into the dry granulator and make granules through mechanical compression and shearing. The pressure is controlled at 10MPa to ensure the compactness and formability of the granules.

[0032] A4: Use a hot air circulation oven, control it at 70℃, dry it for 2 hours, and use a vibrating screen with a mesh size of 280;

[0033] A5: Use a rotary tablet press and control the pressure between 10MPa to ensure the hardness and formability of the tablets;

[0034] A6: Check whether the color, shape, surface finish, etc. of the tablets meet the requirements. Use a hardness tester to measure the hardness of the tablets to ensure that they meet the standards. Use high performance liquid chromatography (HPLC) or other appropriate methods to measure the content of each component in the tablets to ensure that they meet the formulation requirements.

[0035] A7: Use packaging materials that meet pharmaceutical standards, such as bags or bottles, to ensure the stability and safety of tablets during storage and transportation.

[0036] Embodiment 2:

[0037] A composition for improving sleep quality and appetite, comprising the following raw materials in parts by weight: 25 parts of spinach seeds, 10 parts of tuckahoe, 8 parts of rhizoma anemarrhenae, 10 parts of ligusticum chuanxiong, 8 parts of liquorice, and 3 parts of olanzapine, wherein 1.25 mg of olanzapine is provided.

[0038] A method for preparing a composition for improving sleep quality and appetite, characterized in that it also includes the following preparation steps:

[0039] B1. Select high-quality Chinese medicinal materials including 25 parts of Semen Ziziphi Spinosae, 10 parts of Poria, 8 parts of Rhizoma Anemarrhenae, 10 parts of Rhizoma Chuanxiong, 8 parts of Radix Glycyrrhizae, which are free of mildew and insect infestation, and 3 parts of olanzapine; conduct strict quality inspection on all raw materials, including but not limited to appearance, smell, and content determination;

[0040] B2. Mix the Chinese medicinal materials of Semen Ziziphi Spinosae, Poria, Rhizoma Anemarrhenae, Rhizoma Chuanxiong and Radix Glycyrrhizae evenly according to the formula ratio, boil them in water at a temperature of 90°C for 2 hours, and control the material-liquid ratio at 1:8;

[0041] B3, pre-treating the extract in B2 by precipitation, filtering the supernatant by microporous membrane, and concentrating by vacuum concentration technology;

[0042] B4, mixing the concentrated liquid medicine with olanzapine powder evenly according to the formula ratio; granulating the mixed liquid medicine by a spray drying granulator;

[0043] B5. Dry the obtained granules to remove excess moisture; divide and package the dried granules. The packaging materials should meet the requirements of pharmaceutical use to ensure the hygiene and safety of the drugs.

[0044] In summary, the sleep quality and appetite improving composition proposed in the present invention achieves significant improvement in efficacy and effective control of side effects through the organic combination of Chinese and Western medicines and a specific ratio of formulation, while improving the taste and increasing patient compliance, providing a new, safe and effective drug option for improving sleep quality and promoting appetite.

[0045] Among them, Chinese date seeds are sweet and sour, neutral in nature, and enter the liver, gallbladder, and heart meridians. Its main effects include: Nourishing the heart and liver: It can improve symptoms such as insomnia, palpitations, etc., and also has a certain protective effect on the liver. Calming the mind and tranquilizing the nerves: It has a calming effect on the nerves and can be used to treat symptoms such as insomnia, palpitations, and dreams. Retaining sweat: It can be used to treat symptoms such as physical weakness and sweating, and at the same time it can nourish yin and moisten dryness, and relieve symptoms such as dry mouth, dry throat, and dry skin.

[0046] Poria cocos is sweet and light in taste, neutral in nature, and enters the heart, lung, spleen, and kidney meridians. Its main effects include: diuresis and detumescence: It can be used to treat symptoms such as lower limb edema and eyelid edema caused by edema. Strengthening the spleen and eliminating dampness: It helps to treat symptoms such as increased frequency of bowel movements and loose stools caused by weak spleen and stomach. Soothing the mind and calming the nerves: It can be used to treat symptoms such as insomnia and dreaminess caused by restlessness. Enhancing immune function: Poria cocos polysaccharide has the effect of increasing the body's immune function.

[0047] Anemarrhena, bitter and sweet in taste, cold in nature, enters the lung, stomach and kidney meridians. Its main effects are: Clearing away heat and purging fire: It can clear the real heat in the body, especially good at clearing the heat evil in the lung, stomach and kidney meridians. Nourishing yin and moistening dryness: It has the effect of nourishing yin and reducing fire, and can be used to treat various symptoms caused by yin deficiency and fire, such as bone steaming, hot flashes, night sweats, irritability, dry mouth and throat, etc. Lowering blood sugar: Modern pharmacological research believes that Anemarrhena has the effect of assisting in lowering blood sugar.

[0048] Chuanxiong is warm in nature and belongs to the liver, gallbladder, and pericardium meridians. Its main effects are as follows: Activating blood circulation and promoting qi: It can be used to treat coronary heart disease, angina pectoris, chest tightness, breath holding and other symptoms. It also has a good effect on menstrual waist and abdominal pain, dysmenorrhea, excessive leucorrhea, traumatic injuries, and local swelling and pain. Expelling wind and relieving pain: It can be used to treat colds, headaches, rheumatic pain, etc. Activating qi and relieving depression: It can be used to treat upper abdominal distension and pain in the ribs caused by cholecystitis, upper abdominal distension and pain in gastritis, or symptoms such as vomiting acid and heartburn.

[0049] Licorice has the following effects: Clearing away heat and detoxifying: It helps to expel toxins and waste from the body, and has a good effect on reducing heart fire. Expectorant and cough relieving: It helps to improve coughing and sputum. Replenishing the body and replenishing qi: It can replenish the body's lost vital energy, and help treat symptoms such as palpitations, dizziness, and short pulse caused by insufficient heart qi.

[0050] It will be appreciated that in the development of any actual implementation, as in any engineering or design project, numerous implementation-specific decisions may be made. Such a development effort may be complex and time-consuming, but will be a routine task of design, fabrication, and production for those of ordinary skill having the benefit of this disclosure without undue experimentation.

[0051] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present invention, which should all be included in the scope of the claims of the present invention.

Claims

1. A composition for improving sleep quality and appetite, characterized in that: The composition comprises the following raw materials in parts by weight: 20-30 parts of spiny jujube seeds, 8-10 parts of tuckahoe, 6-10 parts of rhizoma anemarrhenae, 10-12 parts of rhizoma ligustici, 8-10 parts of liquorice and 1-5 parts of olanzapine.

2. A composition for improving sleep quality and appetite according to claim 1, characterized in that: The composition comprises the following raw materials in parts by weight: 30 parts of spiny jujube seeds, 10 parts of tuckahoe, 10 parts of rhizoma anemarrhenae, 12 parts of rhizoma ligustici, 10 parts of liquorice and 3 parts of olanzapine.

3. A method for preparing a composition for improving sleep quality and appetite, characterized in that: The following steps are involved: A1. Use a precision electronic scale to weigh the washed and dried Chinese jujube seeds, Poria cocos, Rhizoma Anemarrhenae, Rhizoma Chuanxiong, Licorice and olanzapine accurately, and prepare fillers, disintegrants and lubricants; the fillers include but are limited to lactose and starch, the disintegrants include but are limited to sodium carboxymethyl cellulose and cross-linked polyvinylpyrrolidone, and the lubricants include but are limited to magnesium stearate and talc; A2: Use a pulverizer to grind the Chinese medicine raw materials and auxiliary materials in A1 to a size of 280 mesh or more, and then pour the crushed Chinese medicine raw materials into a three-dimensional mixer for 10-30 minutes; A3: Add the mixed powder into the dry granulator and make granules through mechanical compression and shearing. The pressure is controlled at 5-20MPa to ensure the compactness and formability of the granules. A4: Use a hot air circulation oven, control the temperature between 60-80℃, dry for 1-4 hours, and use a vibrating screen with a mesh size of 280; A5: Use a rotary tablet press and control the pressure between 5-20MPa to ensure the hardness and formability of the tablets; A6: Check whether the color, shape, surface finish, etc. of the tablets meet the requirements. Use a hardness tester to measure the hardness of the tablets to ensure that they meet the standards. Use high performance liquid chromatography (HPLC) or other appropriate methods to measure the content of each component in the tablets to ensure that they meet the formulation requirements. A7: Use packaging materials that meet pharmaceutical standards, such as bags or bottles, to ensure the stability and safety of tablets during storage and transportation.

4. The method for preparing a composition for improving sleep quality and appetite according to claim 3, characterized in that: The following preparation steps are also included: B1. Select high-quality Chinese medicinal materials such as Semen Ziziphi Spinosae, Poria, Rhizoma Anemarrhenae, Rhizoma Chuanxiong, and Radix Glycyrrhizae that are free of mildew and insect infestation, as well as olanzapine; conduct strict quality inspections on all raw materials, including but not limited to appearance, odor, and content determination; B2. Mix the Chinese medicinal materials of spiny jujube seeds, Poria cocos, Anemarrhena asphodeloides, Ligusticum chuanxiong and Licorice evenly according to the formula ratio, boil them in water at a temperature between 80 and 100°C for at least 2 hours, and control the material-liquid ratio between 1:8 and 1:10; B3, pre-treating the extract in B2 by precipitation, filtering the supernatant by microporous membrane, and concentrating by vacuum concentration technology; B4, mixing the concentrated liquid medicine with olanzapine powder evenly according to the formula ratio; granulating the mixed liquid medicine by a spray drying granulator; B5. Dry the obtained granules to remove excess moisture; divide and package the dried granules. The packaging materials should meet the requirements of pharmaceutical use to ensure the hygiene and safety of the drugs.