Fermentation device and method for preparing ganoderma lucidum liver protection agent by using same

Abstract

The invention relates to a fermentation device and a method for preparing a ganoderma liver protection agent by using the same, and relates to the field of biological fermentation technology.According to the main technical scheme, the fermentation device comprises a fermentation tank, a first liquid discharging pipe, a filtering tank, a second liquid discharging pipe, a cylindrical filtering net, a driving mechanism and a uniform distribution mechanism; wherein the fermentation tank is positioned right above the filtering tank, the upper end and the lower end of the first liquid discharge pipe are respectively communicated with the bottom of the fermentation tank and the top of the filtering tank, and a first switch valve is arranged in the first liquid discharge pipe; the second liquid discharge pipe is communicated with the bottom of the fermentation tank and is provided with a second switch valve; the filter screen and the filter tank are coaxially arranged, the upper end of the filter screen is rotationally connected with the inner wall of the lower end of the first liquid discharge pipe, the driving mechanism is used for driving the filter screen to rotate around the axis of the filter tank, and the uniform distribution mechanism is used for distributing medicine residues on the inner circumferential surface of the filter screen. According to the method, liquid medicine residues in the medicine residues can be reduced, so that more preparation liquid is obtained, and the preparation yield is increased.

Description

Technical Field

[0001] The present application relates to the field of biological fermentation technology, and in particular to a fermentation device and a method for preparing a hepatoprotective agent using the device. Background Art

[0002] In traditional Chinese medicine, Tai Sui is called Meat Ganoderma. Tai Sui is rich in 46 kinds of active substances and nutrients needed by the human body, such as pyrroloquinoline quinone, nucleotides, chitin, flavonoids, polysaccharides, glutathione, saponin, chitin, unsaturated fatty acids, SOD, trace elements, amino acids, etc. It has special effects such as anti-tumor, anti-aging, and improving immunity.

[0003] Currently, Tai Sui is fermented with Chinese herbal medicine to obtain preparations, and drinking the preparations can achieve the effect of assisting in the treatment of diseases.

[0004] The existing fermentation device includes a fermentation tank and a filter screen, that is, the fermented liquid is mixed with drug residues, and the filter screen filters out the drug residues in the fermented liquid to prepare the preparation. However, the drug residues on the filter screen still remain in the fermented liquid that is difficult to drain, which will lead to a reduction in the amount of the preparation. Summary of the invention

[0005] In order to increase the amount of preparations obtained, the present application provides a fermentation device and a method for preparing a Tai Sui liver-protecting agent using the device.

[0006] The present application provides a fermentation device, which adopts the following technical solution:

[0007] A fermentation device comprises a fermentation tank, a first drain pipe, a filter tank, a second drain pipe, a cylindrical filter screen, a driving mechanism and a uniform distribution mechanism, wherein the fermentation tank is located directly above the filter tank, the upper end and the lower end of the first drain pipe are respectively connected to the bottom of the fermentation tank and the top of the filter tank, and a first switch valve is provided in the first drain pipe; the second drain pipe is connected to the bottom of the fermentation tank, and a second switch valve is provided in the second drain pipe; the filter screen is coaxially arranged with the filter tank, the upper end of the filter screen is rotatably connected to the inner wall of the lower end of the first drain pipe, the driving mechanism is used to drive the filter screen to rotate around the axis of the filter tank, and the uniform distribution mechanism is used to distribute the drug residue on the inner circumferential surface of the filter screen.

[0008] By adopting the above technical scheme, the Tai Sui stock solution, composite bacterial liquid and fermentation raw materials are placed in a fermentation tank for fermentation. After the fermentation is completed, the first switch valve is opened, and the fermentation liquid containing the drug residue enters the cylindrical filter screen through the first liquid discharge pipe, and the liquid in the fermentation liquid flows into the filter tank through the mesh of the filter screen and is discharged through the second liquid discharge pipe. During this period, the uniform distribution mechanism evenly distributes the drug residue in the fermentation liquid on the inner circumferential surface of the filter screen, and the driving mechanism drives the filter screen to rotate. Under the action of centrifugal force, the residual drug liquid on the drug residue will separate from the drug residue and be discharged from the mesh of the filter screen into the filter tank, that is, the residual drug liquid is thrown out, and the thrown drug liquid is discharged through the second liquid discharge pipe to reduce the residual drug liquid of the drug residue, thereby greatly improving the amount of preparation obtained.

[0009] Optionally, the uniform distribution mechanism includes an inner tube, an outer tube, a spiral piece, a fitting with a cylindrical outer circumference and a control limit assembly, wherein the inner tube, the outer tube, the spiral piece and the fitting are all coaxially arranged with the filter screen, the outer tube is passed through the bottom of the filter tank, the outer tube and the filter screen are connected by a one-way bearing, and the driving mechanism is used to drive the outer tube to rotate forward and reverse; the control limit assembly is used to limit the rotation of the filter screen; the spiral piece is fixed to the outer tube, the outer circumference of the spiral piece is attached to the inner circumference of the filter screen, the inner tube is located in the outer tube, the inner tube and the outer tube are connected to prevent rotation, the fitting is fixedly connected to the inner tube, the outer circumference of the fitting is attached to the inner circumference of the spiral piece, and the upper end of the fitting has a tapered portion, and the tapered portion is located in the first drainage pipe.

[0010] By adopting the above technical scheme, when the fermentation liquid flows down through the first liquid discharge pipe, the fermentation liquid will preferentially flow down along the spiral flow channel formed by the spiral piece, the outer peripheral surface of the fitting and the inner peripheral surface of the filter screen, and the driving mechanism drives the outer tube to rotate in the positive direction. Since the control limit assembly limits the rotation of the filter screen, the filter screen does not move, and the outer tube drives the inner tube, the fitting and the spiral piece to rotate in the positive direction. The rotation of the spiral piece will drive the drug residue in the fermentation liquid to move quickly down to various height positions of the spiral flow channel, so that the drug residue is evenly distributed in the spiral flow channel, and then the driving mechanism drives the outer tube to rotate in the opposite direction, and the control limit assembly releases the limit on the filter screen. The reverse rotation torque of the outer tube will be transmitted to the filter screen through the one-way bearing, so that the inner tube, the fitting, the spiral piece and the filter screen rotate in the opposite direction. Under the action of centrifugal force, the drug residue in the spiral flow channel will be evenly attached to the inner peripheral surface of the filter screen to throw out the residual drug liquid.

[0011] Optionally, it also includes a slag discharge mechanism, which includes an air suction assembly and two jet assemblies, the inner tube is connected to the outer tube in a rotation-stopping and axially sliding manner, and the outer tube is provided with an axial limit assembly for preventing the inner tube from sliding, the matching piece is provided with a cylindrical airbag, the upper end of the airbag has the conical portion, the airbag is fixed to the inner tube, and the outer circumferential surface of the airbag is in contact with the inner circumferential surface of the spiral sheet; a microporous tube is coaxially connected and fixed to the upper end of the inner tube, the microporous tube has micropores that are arranged through it, the diameter of the microporous tube is smaller than the diameter of the inner tube, the microporous tube is located in the airbag, and the air suction assembly is used to extract or inhale air from the inner tube; the two jet assemblies are symmetrically arranged with the axis of the filter as the center, and the direction of the gas ejected by the jet assembly is toward the axis of the filter.

[0012] By adopting the above technical solution, in the filtering state, the airbag is filled with air, the outer circumference of the airbag is attached to the inner circumference of the spiral sheet, and the airbag rotates with the inner tube; after the filtering is completed, the jet assembly blows air, and the filter screen keeps rotating in the opposite direction to blow the medicine residue on the inner circumference of the filter screen to the outer circumference of the airbag and the surface of the spiral sheet, and then the suction air assembly sucks air into the airbag, the airbag contracts, and the airbag takes the medicine residue away from the spiral sheet, and then the jet assembly continues to spray to blow the medicine residue on the spiral sheet off and blow it to the vicinity of the inner tube, and move the inner tube downward to drive the airbag to move downward and out of the outer tube, and the medicine residue near the inner tube falls out of the outer tube under the action of gravity, thereby completing the cleaning of the medicine residue.

[0013] That is, by setting up a slag discharge mechanism, under the action of the jet of the jet assembly and the contraction of the airbag, the medicine residue in the spiral flow channel adheres to the outer peripheral surface of the airbag and is blown to the position of the inner tube, and then the inner tube is moved downward and moved out of the outer tube, so as to realize the cleaning of the medicine residue, which is convenient and quick.

[0014] Optionally, the outer peripheral surface of the airbag is set to be a rough surface.

[0015] By adopting the above technical solution, the adhesion effect of the drug residue can be improved, so as to improve the effect of the air bag taking away the drug residue.

[0016] Optionally, a spiral diaphragm is provided in the airbag, the inner circumference of the diaphragm is fitted and fixed to the microporous tube, and the outer circumference of the diaphragm is integrally formed with a thickened section, and the thickened section is fitted and fixed to the inner circumference of the airbag.

[0017] By adopting the above technical solution and setting a diaphragm to form a spiral air cavity, the gas in the air cavity is evenly distributed, so that the expansion and contraction degrees of the airbag are more stable.

[0018] By providing a thickened section, the connection strength between the diaphragm and the airbag is improved, so that the connection point is not easily stretched and moved due to inflation, and the non-connection point of the airbag is easier to deform. When there is too much gas in the airbag, the outer peripheral surface of the airbag will expand to form a spiral protrusion, which is located in the spiral flow channel to further squeeze the drug residue in the spiral flow channel, thereby further increasing the discharge effect of residual drug liquid.

[0019] Optionally, a plurality of flexible hairs are integrally formed on the outer peripheral surface of the airbag at the spiral gap of the spiral sheet. The flexible hairs are perpendicular to the outer peripheral surface of the airbag. The diameter of the flexible hairs gradually increases in the direction away from the axis of the airbag, and an entrainment gap is formed between adjacent flexible hairs.

[0020] By adopting the above technical solution and setting flexible hairs, when the airbag forms a spiral protrusion, the flexible hairs are in an outward expansion state and the entrainment gap is larger. Therefore, the drug residue pushed away by the jet can more easily enter the entrainment gap. When the airbag contracts to take away the drug residue, the entrainment gap is smaller and multiple flexible hairs will grab the drug residue to reduce the occurrence of the drug residue escaping from the airbag, thereby improving the slag removal effect.

[0021] Optionally, the control limit assembly includes a limit ring, a first limit rod and a first rubber sleeve, the limit ring sleeve is fixed to the upper end of the filter net, the top of the filter tank is vertically provided with a first through hole, the first limit rod is vertically slidably connected to the first through hole, and the first rubber sleeve is fixed to the inner wall of the first through hole; the upper surface of the limit ring is provided with a first limit hole for inserting the lower end of the first limit rod.

[0022] By adopting the above technical solution, the rotation limit and limit contact of the filter screen can be realized by controlling the cooperation between the first limit rod and the first limit hole, which is convenient and quick.

[0023] The present application also provides a method for preparing a hepatoprotective agent using a fermentation device, which adopts the following technical solution:

[0024] A method for preparing a hepatoprotective agent using a fermentation device comprises the following steps:

[0025] S1. Material selection: Cyclocarya paliurus, Scindapsus scindapsus, Salvia miltiorrhiza, Gynostemma pentaphyllum, Eucommia ulmoides, Astragalus membranaceus, and Dendrobium candidum are selected as fermentation raw materials;

[0026] S2, material processing: soak the fermentation raw materials in NaCl solution, then drain and crush them for later use;

[0027] S3, bacterial culture: Activate the Tai Sui stock solution with mineral water and edible fructose, and culture at a constant temperature of 26°C for 10 days to obtain the Tai Sui stock solution composite bacterial solution;

[0028] S4, inoculation fermentation: dissolving the fermentation raw materials, Cordyceps sinensis powder, and chromium-enriched yeast in pure water to obtain a fermentation semi-finished material, and then adding the Tai Sui stock solution composite bacterial liquid and the fermentation semi-finished material into the fermentation tank to ferment, and obtaining a fermentation liquid after the fermentation is completed;

[0029] S5, filtration treatment: open the first switch valve, the fermentation liquid containing the drug residue enters the filter screen through the first drain pipe, the liquid in the fermentation liquid flows into the filter tank through the mesh of the filter screen, and is discharged through the second drain pipe; the uniform distribution mechanism evenly distributes the drug residue in the fermentation liquid on the inner circumference of the filter screen, the driving mechanism drives the filter screen to rotate, and under the action of centrifugal force, the drug liquid remaining on the drug residue will separate from the drug residue and be discharged from the mesh of the filter screen into the filter tank; the drug liquid discharged from the second drain pipe is the Tai Sui liver protection preparation.

[0030] Optionally, in step S2, the fermentation raw material is first rinsed with tap water, then washed twice with purified water, and finally soaked in a NaCl solution with a mass concentration of 10 g / L for 30 minutes, drained and crushed for later use.

[0031] Optionally, the pH value of the Tai Sui liver protection preparation is 3.5-4.0.

[0032] In summary, the present application includes at least one of the following beneficial technical effects:

[0033] 1. By setting up a filter screen, a driving mechanism and a uniform distribution mechanism, the residual liquid in the drug residue can be efficiently thrown out to obtain more preparation liquid, thereby increasing the preparation yield;

[0034] 2. The Tai Sui liver protection preparation prepared by the preparation method is pasteurized and then directly eaten with an appropriate amount of honey. The Tai Sui liver protection preparation has a liver protection effect and has a significant therapeutic effect on metabolic diseases such as hyperglycemia and diabetes;

[0035] 3. By setting up a slag discharge mechanism, under the action of the jet of the jet assembly and the contraction of the airbag, the medicine residue in the spiral flow channel adheres to the outer peripheral surface of the airbag and the medicine residue is blown to the position of the inner tube, and then the inner tube is moved downward and moved out of the outer tube to realize the cleaning of the medicine residue, which is convenient and quick. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] Figure 1 It is a cross-sectional view of the overall structure of Example 1.

[0037] Figure 2 yes Figure 1 A partial enlarged view of point A in the middle.

[0038] Figure 3 yes Figure 1 A partial enlarged view of point B in the middle.

[0039] Figure 4 Schematic diagram of the spiral blade of Example 1.

[0040] Figure 5 yes Figure 1 A partial enlarged view of point C in the middle.

[0041] Figure 6 It is a flow chart of the preparation method of Example 2.

[0042] Figure 7 It is a cross-sectional view of the overall structure of Example 3.

[0043] Figure 8 yes Figure 7 A partial enlarged view of point D in the middle.

[0044] Fig. 9 It is a cross-sectional view of the overall structure of Example 4.

[0045] Fig.10 yes Fig. 9 A partial enlarged view of point E in the middle.

[0046] Fig.11 It is a partial cross-sectional view of the airbag of Example 5 in an expanded state.

[0047] Fig.12 It is a partial cross-sectional view of the airbag of Example 5 in a deflated state.

[0048] Explanation of reference numerals: 1. fitting; 2. filter screen; 3. outer tube; 5. inner tube; 6. spiral sheet; 7. jet assembly; 10. fermenter; 101. tank body; 102. tank cover; 103. stirring motor; 104. stirring rod; 105. first liquid discharge pipe; 106. first switch valve; 11. conical portion; 12. air bag; 13. microporous tube; 14. rotary joint; 15. connecting pipe; 16. diaphragm; 161. thickened section; 17. protrusion; 18. flexible hair; 19. entrainment Gap; 20, filter tank; 201, second drain pipe; 202, first through hole; 21, limit ring; 22, first limit rod; 23, first rubber sleeve; 24, first limit hole; 25, first connecting plate; 26, one-way bearing; 31, second connecting plate; 32, drive motor; 33, gear; 34, gear ring; 35, keyway; 36, second limit rod; 37, second through hole; 38, second rubber sleeve; 51, key block; 52, second limit hole; 71, air pipe; 72, nozzle. DETAILED DESCRIPTION

[0049] The following is combined with Figure 1-12 This application is described in further detail.

[0050] Example 1

[0051] Example 1 discloses a fermentation device. Figure 1 The fermentation device includes a fermentation tank 10, a first drainage pipe 105, a filter tank 20, a second drainage pipe 201, a cylindrical filter screen 2, a driving mechanism and a uniform distribution mechanism, wherein the fermentation tank 10 is located directly above the filter tank 20, the fermentation tank 10 includes a tank body 101 and a tank cover 102, the upper end and the lower end of the first drainage pipe 105 are respectively connected and fixed to the bottom of the fermentation tank 10 and the top of the filter tank 20, a first switch valve 106 is provided in the first drainage pipe 105, the second drainage pipe 201 is connected to the bottom of the fermentation tank 10, and the second drainage pipe 201 is provided with a second switch valve (not shown in the figure).

[0052] The fermentation tank 10 is used for fermentation. In order to improve the fermentation effect, the fermentation tank 10 can also be provided with a stirring mechanism, which includes a stirring rod 104 and a stirring motor 103. The stirring motor 103 is installed on the tank cover 102, and the stirring rod 104 passes through the tank cover 102 and is located in the tank body 101.

[0053] like Figure 1 , Figure 2 As shown, the filter screen 2 is located in the filter tank 20, and the filter screen 2 is coaxially arranged with the filter tank 20. The upper end of the filter screen 2 is rotatably connected to the inner wall of the lower end of the first drain pipe 105, and the inner diameter of the filter screen 2 is equal to the inner diameter of the first drain pipe 105. In addition, the filter tank 20 is provided with a control limit assembly, which is used to rotationally limit the filter screen 2 or release the limit of the filter screen 2. Specifically, the control limit assembly includes a limit ring 21, a first limit rod 22 and a first rubber sleeve 23. The limit ring 21 is sleeved and fixed on the upper end of the filter screen 2, and the upper surface of the limit ring 21 is attached to the inner top wall of the filter tank 20. The top of the filter tank 20 A first through hole 202 is vertically opened on the part, and the first limiting rod 22 is vertically slidably connected to the first through hole 202. The first rubber sleeve 23 is fixed to the inner wall of the first through hole 202, so that the sliding of the first limiting rod 22 has damping. A first limiting hole 24 is opened on the upper surface of the limiting ring 21 for the lower end of the first limiting rod 22 to be inserted, that is, through the cooperation between the first limiting rod 22 and the first limiting hole 24, the filter screen 2 and the filter tank 20 are relatively fixed, and the movement of the first limiting rod 22 can be manual or automatic. In other embodiments, an electric push rod can be set on the top of the filter tank 20, and the electric push rod drives the first limiting rod 22 to move vertically.

[0054] like Figure 1 , Figure 3 , Figure 4As shown, the uniform distribution mechanism is used to arrange the medicinal residue on the inner circumference of the filter screen 2. Specifically, the uniform distribution mechanism includes an inner tube 5, an outer tube 3, a spiral sheet 6, and a matching piece 1 with a cylindrical outer circumference, wherein the inner tube 5, the outer tube 3, the spiral sheet 6, and the matching piece 1 are all coaxially arranged with the filter screen 2, the outer tube 3 is penetrated at the bottom of the filter tank 20, the outer tube 3 is rotatably connected with the filter tank 20, and the outer tube 3 is connected with the filter screen 2 through a one-way bearing 26. Specifically, a first annular connecting plate 25 is fixed to the lower tube mouth of the filter screen 2, and the one-way bearing 26 is arranged on the inner circumference of the first connecting plate 25 and the outer circumference of the outer tube 3. The driving mechanism is used to drive the outer tube 3 to rotate forward and reverse. When the outer tube 3 rotates forward, the outer tube 3 and the filter screen 2 rotate relative to each other, that is, the torque of the outer tube 3 will not be transmitted to the filter screen 2, and when the outer tube 3 rotates reversely, the torque of the outer tube 3 will be transmitted to the filter screen 2 through the one-way bearing 26 to drive the filter screen 2 to rotate.

[0055] The driving mechanism includes a driving motor 32, a ring gear 34 and a gear 33. The driving motor 32 is installed at the bottom of the filter tank 20, the gear 33 is installed on the output shaft of the driving motor 32, the ring gear 34 is sleeved and fixed on the part of the outer tube 3 located outside the filter tank 20, and the gear 33 and the ring gear 34 are meshed.

[0056] like Figure 1 , Figure 3 , Figure 4 As shown, the outer circumferential surface of the spiral piece 6 is attached to the inner circumferential surface of the filter screen 2, and the spiral piece 6 is fixed to the outer tube 3, that is, the outer tube 3 can drive the spiral piece 6 to rotate. Specifically, an annular second connecting plate 31 is fixed to the upper end of the outer tube 3, the second connecting plate 31 is coaxial with the outer tube 3, the second connecting plate 31 is attached to the upper surface of the first connecting plate 25, and the lower end of the spiral piece 6 is fixed to the second connecting plate 31.

[0057] The inner tube 5 is located inside the outer tube 3. The outer diameter of the inner tube 5 is smaller than the inner diameter of the outer tube 3. There is an annular gap between the inner tube 5 and the outer tube 3. The inner tube 5 is non-rotatably connected to the outer tube 3. Specifically, a key groove 35 axially penetrates the inner circumference of the outer tube 3. A key block 51 is fixed to the outer circumference of the inner tube 5. The key block 51 is connected to the key groove 35 in an axial sliding manner along the outer tube 3, so that the torque of the outer tube 3 can be transmitted to the inner tube 5.

[0058] In order to limit the axial position of the inner tube 5, the outer tube 3 is also provided with an axial limit assembly, such as Figure 5 As shown, it includes a second limiting rod 36 and a second rubber sleeve 38. The outer tube 3 is radially provided with a second through hole 37. The second limiting rod 36 is vertically slidably connected to the second through hole 37. The second rubber sleeve 38 is fixed to the inner wall of the second through hole 37 so that the sliding of the second limiting rod 36 has damping. The outer circumferential surface of the inner tube 5 is provided with a second limiting hole 52 for inserting the end of the second limiting rod 36.

[0059] The upper end of the inner tube 5 is fixed to the bottom of the fitting 1. The fitting 1 can be a cylindrical metal part or a cylindrical hollow tube. The outer circumferential surface of the fitting 1 is attached to the inner circumferential surface of the spiral sheet 6. The bottom of the fitting 1 is attached to the upper surface of the second connecting plate 31. The upper end of the fitting 1 has a tapered portion 11, and the tapered portion 11 is located in the first drain pipe 105.

[0060] The implementation principle of Example 1 is as follows: the original compound bacterial liquid of Tai Sui and the fermentation raw materials are placed in the fermentation tank 10 for fermentation. After the fermentation is completed, the first switch valve 106 is opened, and the fermentation liquid containing the drug residue enters the cylindrical filter screen 2 through the first liquid discharge pipe 105. The liquid in the fermentation liquid flows into the filter tank 20 through the mesh of the filter screen 2 and is discharged through the second liquid discharge pipe 201. The fermentation liquid preferentially flows down along the spiral flow channel formed by the spiral piece 6, the outer peripheral surface of the fitting 1, and the inner peripheral surface of the filter screen 2. The driving mechanism drives the outer tube 3 to rotate forward. Since the control limit assembly limits the rotation of the filter screen 2, the filter screen 2 does not move, and the outer tube 3 drives the inner tube 5, the fitting 1 and the spiral piece 6 to rotate forward. The rotation of the spiral piece 6 will drive the fermentation liquid The drug residue quickly moves down to various height positions of the spiral flow channel, so that the drug residue is evenly distributed in the spiral flow channel, and then the driving mechanism drives the outer tube 3 to rotate in the opposite direction, and controls the limit assembly to release the limit on the filter screen 2 (the first limit rod 22 is disengaged from the first limit hole 24), so that the filter screen 2 is in a free rotation state, and the reverse rotation torque of the outer tube 3 will be transmitted to the filter screen 2 through the one-way bearing 26 to drive the inner tube 5, the fitting 1, the spiral sheet 6 and the filter screen 2 to rotate in the opposite direction. Under the action of centrifugal force, the drug residue in the spiral flow channel will be evenly attached to the inner circumferential surface of the filter screen 2 and continue to rotate to throw out the residual liquid medicine, and the thrown liquid medicine is discharged through the second liquid discharge pipe 201 to reduce the residual liquid medicine in the drug residue, thereby greatly improving the amount of preparation obtained.

[0061] When the medicinal residue needs to be discharged, the driving mechanism stops driving, releases the axial limit on the inner tube 5 (the second limit rod 36 disengages from the second limit hole 52), moves the inner tube 5 upward to bring the fitting 1 away from the second connecting plate 31, and then introduces water into the fermentation tank 10. The water will enter the spiral flow channel in the filter screen 2 from the first drain pipe 105 to drive the medicinal residue in the spiral flow channel to move downward. The medicinal residue will pass through the gap between the bottom of the fitting 1 and the second connecting plate 31, and the gap between the inner tube 5 and the outer tube 3 in turn, and finally be discharged from the lower end of the outer tube 3, thereby completing the cleaning of the medicinal residue.

[0062] Example 2

[0063] Example 2 discloses a method for preparing a liver-protecting agent using a fermentation device, such as Figure 6 As shown, the following steps are included:

[0064] S1. Material selection: Cyclocarya paliurus, Scindapsus scindapsus, Salvia miltiorrhiza, Gynostemma pentaphyllum, Eucommia ulmoides, Astragalus membranaceus, and Dendrobium officinale are selected as fermentation raw materials.

[0065] S2. Material processing: rinse the fermentation raw materials with tap water first, then wash twice with purified water, and finally soak them in a 10g / L NaCl solution for 30 minutes, drain and crush them for later use.

[0066] S3. Bacterial culture: Use mineral water to activate the scientifically cultured Tai Sui stock solution. The specific method is to take 50 mL of Tai Sui stock solution, add 400 mL of mineral water and 50 mL of edible fructose, and culture at a constant temperature of 26°C for 10 days to obtain 500 mL of Tai Sui stock solution composite bacterial liquid.

[0067] S4, inoculation fermentation: according to the inoculation ratio of 30%, the fermentation raw materials, Cordyceps sinensis powder, and chromium-rich yeast are dissolved in pure water to obtain fermentation semi-finished material, and then the Gastrodia elata stock solution (the concentration of the Gastrodia elata stock solution is 106 CFU / ml) and the fermentation semi-finished material are added into the fermentation tank 10, and fermented for 15 days at a temperature of 25-32° C. After fermentation is mature, the pH value of the fermentation liquid is 3.5-4.0.

[0068] S5, filtration treatment: open the first switch valve 106, the fermentation liquid containing the drug residue enters the filter screen 2 through the first drain pipe 105, the liquid in the fermentation liquid flows into the filter tank 20 through the mesh of the filter screen 2, and is discharged through the second drain pipe 201, the driving mechanism drives the filter screen 2 to rotate, and the uniform distribution mechanism distributes the drug residue in the fermentation liquid on the inner circumferential surface of the filter screen 2. Under the action of centrifugal force, the drug liquid remaining on the drug residue will separate from the drug residue and be discharged from the mesh of the filter screen 2 into the filter tank 20, and be discharged from the second drain pipe 201.

[0069] The liquid medicine discharged from the second liquid discharge pipe 201 is a liver-protecting preparation of Tai Sui, and the pH value of the liver-protecting preparation of Tai Sui is 3.5 to 4.0. After pasteurization, the liver-protecting preparation of Tai Sui can be directly drunk by adding an appropriate amount of honey.

[0070] Example 3

[0071] The difference between Example 3 and Example 1 is that Figure 7 , Figure 8 As shown, the fermentation device also includes a slag discharge mechanism for improving the cleaning effect of the medicinal residue.

[0072] The slag discharge mechanism includes a suction air component and two jet components 7. The matching part 1 is set as a cylindrical airbag 12. The airbag 12 is made of rubber. The outer peripheral surface of the airbag 12 is set as a rough surface. The upper end of the airbag 12 is conical, that is, the upper end of the airbag 12 is a conical portion 11. The upper end of the inner tube 5 is coaxially connected and fixed with a microporous tube 13. The diameter of the microporous tube 13 is smaller than the diameter of the inner tube 5. The microporous tube 13 has micropores (not marked in the figure) arranged through it. The microporous tube 13 is located in the airbag 12. The lower end of the airbag 12 is fixedly connected to the upper end of the inner tube 5, and the upper end of the airbag 12 is fixedly connected to the upper end of the microporous tube 13, so that the torque of the inner tube 5 can be transmitted to The air bag 12 and the suction air assembly are used to evacuate or inhale the inner tube 5. The suction air assembly includes a connecting tube 15 and a suction pump (not shown in the figure). The connecting tube 15 is a hose. One end of the connecting tube 15 is connected to the lower end of the inner tube 5 through a rotating joint 14, and the other end of the connecting tube 15 is connected to the suction pump. When the connecting tube 15 is connected to the suction end of the suction pump, the air bag 12 can be inhaled. When the connecting tube 15 is connected to the discharge end of the suction pump, the air bag 12 can be blown. The outer circumference of the air bag 12 in the expanded state is attached to the inner circumference of the spiral sheet 6 to form a complete spiral flow channel to facilitate the uniform distribution of the drug residue.

[0073] The two jet assemblies 7 are symmetrically arranged with the axis of the filter 2 as the center. The jet assembly 7 includes multiple air pipes 71 and nozzles 72. The air pipes 71 are arranged at intervals along the axial direction of the filter tank 20. The air pipes 71 pass through the filter tank 20. The nozzles 72 are installed at the ends of the air pipes 71. The direction of the gas ejected by the nozzles 72 is toward the axis of the filter 2.

[0074] After the filtration is completed, the filter screen 2 keeps rotating in the reverse direction at a slow speed, and the drug residue is located on the inner circumference of the filter screen 2. The nozzle 72 blows air to blow the drug residue on the inner circumference of the filter screen 2 to the outer circumference of the air bag 12 (part of the drug residue adheres to the outer circumference of the air bag 12) and the surface of the spiral sheet 6, and then the suction air component inhales air to the air bag 12, and the air bag 12 shrinks toward the microporous tube 13, and the air bag 12 gradually fits the microporous tube 13. The air bag 12 takes the drug residue away from the spiral sheet 6, and then the jet component 7 continues to jet to blow the drug residue of the spiral sheet 6 off and blow it to the vicinity of the inner tube 5 (near the microporous tube 13), and then the axial limit component is released and the inner tube 5 is moved downward to drive the air bag 12 to move downward and move out of the outer tube 3, and the drug residue near the inner tube 5 also falls out of the outer side of the outer tube 3 under the action of gravity, and finally the drug residue on the outer surface of the air bag 12 is cleaned, thereby completing the cleaning of the drug residue.

[0075] When filtering is needed again, the cleaned air bag 12 is extended from the outer tube 3 into the filter screen 2 and reinstalled.

[0076] Example 4

[0077] The difference between Example 4 and Example 3 is that Fig. 9 , Fig.10As shown, a spiral diaphragm 16 is provided in the airbag 12. Specifically, the diaphragm 16 is made of the same material as the airbag 12, the inner circumference of the diaphragm 16 is adhered and bonded to the microporous tube 13, and the outer circumference of the diaphragm 16 is integrally formed with a thickened section 161, and the thickened section 161 is adhered and bonded to the inner circumference of the airbag 12. Since the diaphragm 16 is spiral, the thickened section 161 is also spiral, and the connection position between the airbag 12 and the thickened section 161 is also spiral, and the connection position is directly opposite to the inner circumference of the spiral sheet 6.

[0078] The thickened section 161 can improve the connection strength between the diaphragm 16 and the airbag 12, so that the connection position is not easily stretched and moved due to excessive inflation. In contrast, the non-connected position of the airbag 12 is more likely to deform. Therefore, when there is too much gas in the airbag 12, the outer peripheral surface of the airbag 12 will expand to form a spiral protrusion 17, which is located in the spiral flow channel to further squeeze the drug residue in the spiral flow channel, thereby further increasing the discharge effect of the residual drug solution. In addition, the thickness of the part of the airbag 12 located at the protrusion 17 can be thinned to make the protrusion 17 easier to expand and deform.

[0079] Example 5

[0080] The difference between Example 5 and Example 4 is that Fig.11 , Fig.12 As shown, a plurality of flexible hairs 18 are integrally formed on the outer peripheral surface of the airbag 12 at the spiral gap of the spiral sheet 6, that is, a plurality of flexible hairs 18 are integrally formed on the outer peripheral surface of the protrusion 17, and the flexible hairs 18 are perpendicular to the outer peripheral surface of the protrusion 17. The diameter of the flexible hairs 18 gradually increases in the direction away from the axis of the airbag 12, and an entrainment gap 19 is formed between adjacent flexible hairs 18.

[0081] When the airbag 12 forms the spiral protrusion 17, the flexible hair 18 is in an outward expansion state (see Fig.11 ), the entrainment gap 19 is larger, so the medicine residue pushed away from the filter screen 2 by the air jet is easier to enter the entrainment gap 19, and when the air bag 12 contracts to take away the medicine residue, due to the presence of the thickened section 161, the protrusion 17 is preferentially concave, making the entrainment gap 19 smaller (see Fig.12 ), a plurality of flexible hairs 18 jointly grasp the medicine residue to reduce the occurrence of the medicine residue escaping from the air bag 12, thereby improving the slag removal effect.

[0082] The above are all preferred embodiments of the present application, and the protection scope of the present application is not limited thereto. Therefore, any equivalent changes made according to the structure, shape, and principle of the present application should be included in the protection scope of the present application.

Claims

1. A fermentation device, characterized in that: The invention comprises a fermentation tank (10), a first liquid discharge pipe (105), a filter tank (20), a second liquid discharge pipe (201), a cylindrical filter screen (2), a driving mechanism and a uniform distribution mechanism, wherein the fermentation tank (10) is located directly above the filter tank (20), the upper end and the lower end of the first liquid discharge pipe (105) are respectively connected to the bottom of the fermentation tank (10) and the top of the filter tank (20), and a first switch valve (106) is arranged in the first liquid discharge pipe (105); the second liquid discharge pipe (201) is connected to the bottom of the fermentation tank (10), and the second liquid discharge pipe (201) is provided with a second switch valve; the filter screen (2) is coaxially arranged with the filter tank (20), the upper end of the filter screen (2) is rotatably connected to the inner wall of the lower end of the first liquid discharge pipe (105), the driving mechanism is used to drive the filter screen (2) to rotate around the axis of the filter tank (20), and the uniform distribution mechanism is used to distribute the medicinal residue on the inner circumferential surface of the filter screen (2).

2. The fermentation device according to claim 1, characterized in that: The uniform distribution mechanism comprises an inner tube (5), an outer tube (3), a spiral sheet (6), a matching piece (1) with a cylindrical outer circumference, and a control limit assembly, wherein the inner tube (5), the outer tube (3), the spiral sheet (6), and the matching piece (1) are all coaxially arranged with the filter screen (2); the outer tube (3) is passed through the bottom of the filter tank (20); the outer tube (3) and the filter screen (2) are connected via a one-way bearing (26); the driving mechanism is used to drive the outer tube (3) to rotate forward and reverse; the control limit assembly is used to control the filter screen The mesh (2) is limited in rotation; the spiral piece (6) is fixedly arranged with the outer tube (3), the outer peripheral surface of the spiral piece (6) is in contact with the inner peripheral surface of the filter mesh (2), the inner tube (5) is located inside the outer tube (3), the inner tube (5) and the outer tube (3) are connected to each other in a rotation-stopping manner, the matching piece (1) is fixedly connected with the inner tube (5), the outer peripheral surface of the matching piece (1) is in contact with the inner peripheral surface of the spiral piece (6), and the upper end of the matching piece (1) has a tapered portion (11), and the tapered portion (11) is located inside the first liquid discharge pipe (105).

3. The fermentation device according to claim 2, characterized in that: The invention also comprises a slag discharge mechanism, the slag discharge mechanism comprising a suction gas assembly and two injection assemblies (7), the inner tube (5) and the outer tube (3) are connected to each other in a rotation-stopping and axially sliding manner, and the outer tube (3) is provided with an axial limit assembly for preventing the inner tube (5) from sliding, the matching piece (1) is configured as a cylindrical airbag (12), the upper end of the airbag (12) has the tapered portion (11), the airbag (12) is fixed to the inner tube (5), and the outer peripheral surface of the airbag (12) is attached to the inner surface of the spiral sheet (6). The inner tube (5) has a microporous tube (13) coaxially connected and fixed to its upper end, the microporous tube (13) having micropores extending therethrough, the diameter of the microporous tube (13) being smaller than the diameter of the inner tube (5), the microporous tube (13) being located in the airbag (12), and the suction component being used for suctioning or inhaling air from the inner tube (5); and the two jet components (7) being symmetrically arranged with the axis of the filter screen (2) as the center, and the direction of the gas ejected by the jet component (7) being toward the axis of the filter screen (2).

4. The fermentation device according to claim 3, characterized in that: The outer peripheral surface of the airbag (12) is set to be a rough surface.

5. The fermentation device according to claim 3, characterized in that: A spiral diaphragm (16) is provided inside the airbag (12), the inner circumference of the diaphragm (16) is fitted and fixed to the microporous tube (13), and the outer circumference of the diaphragm (16) is integrally formed with a thickened section (161), and the thickened section (161) is fitted and fixed to the inner circumference of the airbag (12).

6. The fermentation device according to claim 5, characterized in that: A plurality of flexible hairs (18) are integrally formed at a portion of the outer peripheral surface of the airbag (12) located in the spiral gap of the spiral sheet (6); the flexible hairs (18) are perpendicular to the outer peripheral surface of the airbag (12); the diameter of the flexible hairs (18) gradually increases in a direction away from the axis of the airbag (12); and an entrainment gap (19) is formed between adjacent flexible hairs (18).

7. The fermentation device according to claim 2, characterized in that: The control limit assembly comprises a limit ring (21), a first limit rod (22) and a first rubber sleeve (23); the limit ring (21) is sleeved and fixed on the upper end of the filter screen (2); a first through hole (202) is vertically opened on the top of the filter tank (20); the first limit rod (22) is vertically slidably connected to the first through hole (202); the first rubber sleeve (23) is fixed to the inner wall of the first through hole (202); and a first limit hole (24) is opened on the upper surface of the limit ring (21) for the lower end of the first limit rod (22) to be inserted.

8. A method for preparing a hepatoprotective agent using the fermentation device according to claim 1, characterized in that: The following steps are involved: S1. Material selection: Cyclocarya paliurus, Scindapsus scindapsus, Salvia miltiorrhiza, Gynostemma pentaphyllum, Eucommia ulmoides, Astragalus membranaceus, and Dendrobium candidum are selected as fermentation raw materials; S2, material processing: soak the fermentation raw materials in NaCl solution, then drain and crush them for later use; S3, bacterial culture: Activate the Tai Sui stock solution with mineral water and edible fructose, and culture at a constant temperature of 26°C for 10 days to obtain the Tai Sui stock solution composite bacterial solution; S4, inoculation fermentation: dissolving the fermentation raw materials, Cordyceps sinensis powder, and chromium-enriched yeast in pure water to obtain a fermentation semi-finished material, and then adding the Gastrodia elata stock solution, composite bacterial liquid and the fermentation semi-finished material into the fermentation tank (10) to carry out fermentation, and obtaining a fermentation liquid after the fermentation is completed; S5, filtering treatment: the first switch valve (106) is opened, and the fermentation liquid containing the medicinal residue enters the filter screen (2) through the first liquid discharge pipe (105), and the liquid in the fermentation liquid flows into the filter tank (20) through the mesh of the filter screen (2) and is discharged through the second liquid discharge pipe (201); the uniform distribution mechanism uniformly distributes the medicinal residue in the fermentation liquid on the inner peripheral surface of the filter screen (2), and the driving mechanism drives the filter screen (2) to rotate. Under the action of centrifugal force, the medicinal liquid remaining on the medicinal residue will separate from the medicinal residue and be discharged from the mesh of the filter screen (2) into the filter tank (20); the medicinal liquid discharged from the second liquid discharge pipe (201) is the Tai Sui liver protection preparation.

9. The method for preparing the Tai Sui liver-protecting agent according to claim 8, characterized in that: In step S2, the fermentation raw material is first rinsed with tap water, then washed twice with purified water, and finally soaked in a NaCl solution with a mass concentration of 10 g / L for 30 minutes, drained and crushed for later use.

10. The method for preparing the Tai Sui liver-protecting agent according to claim 8, characterized in that: The pH value of the Tai Sui liver protection preparation is 3.5-4.0.

Images