Pathological tissue cutting equipment

By introducing flexible fixtures and cooling systems into the pathological tissue sectioner, the problem of insufficient fixation and cracks during sectioning of living tissue is solved, and stable clamping and low-temperature treatment of tissue are achieved to ensure the integrity and quality of the section.

CN119269150APending Publication Date: 2025-01-07FUJIAN MEDICAL UNIV UNION HOSPITAL
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Patent Information

Application Number
CN202411415431.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-10-11
Publication Date
2025-01-07

AI Technical Summary

Technical Problem

At this stage, the pathological tissue sectioning machine is insufficient to section live tissue, resulting in dislocation of tissue posture, and small cracks or crack defects with uncertain positions often appear after sectioning.

Method used

A pathological tissue cutting device including a flexible fixture and a cooling system is designed. The flexible fixture drives the half-circle gear rotation through a servo motor and a driving gear to ensure stable clamping of the tissue; the cooling system provides low-temperature air through a servo air pump and a vortex tube to prevent wax Cracks caused by excessive block temperature.

Benefits of technology

Effectively and stably clamp the pathological tissue, prevent posture shifts and cracks during sectioning, and ensure the integrity and quality of the section.

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Abstract

The invention discloses pathological tissue cutting equipment, relates to the technical field of living tissue slicing machine equipment, and provides the following scheme that the pathological tissue cutting equipment comprises a slicing mechanism, and a pathological tissue placing table is arranged in the front side area of the top surface of the slicing mechanism; two pathological tissue flexible clamps are movably arranged on the surface of the top of the pathological tissue placing table, a pathological tissue cooling system is fixedly connected to the surface of the bottom of the pathological tissue placing table, and the slicing mechanism comprises two bases arranged left and right and a bottom plate fixed to the upper surfaces of the bases; the shell is fixed on the right side of the rear surface of the bottom plate. According to the technical scheme, a set of flexible clamps are arranged on the working face of the pathological tissue slicing machine, and the posture of the pathological tissue is stabilized while the pathological tissue is not damaged and is excessively pressed. And a cooling system is arranged on the working surface of the pathological tissue slicing machine, so that the temperature of the wax block wrapping the pathological tissue is prevented from being too high, and the wax block is cooled to prevent the slice from cracking.
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Description

Technical Field

[0001] The invention relates to the technical field of living tissue slicer equipment, and in particular to a pathological tissue cutting device. Background Art

[0002] Pathological tissue cutting refers to taking a certain size of diseased tissue, making pathological sections using pathological histological methods (usually embedding the diseased tissue in a paraffin block, cutting it into thin slices with a slicer, and then staining it with hematoxylin-eosin), and further examining the lesions with a microscope. However, the inventors have found that the current pathological tissue slicers are not able to fix the tissue adequately when slicing living tissue, and the posture of the tissue shifts when cutting. In addition, since the tissue is immersed in wax and embedded during embedding, the high temperature during slicing causes defects such as several small cracks or fissures in uncertain positions to appear on the sliced ​​sample. Therefore, those skilled in the art have proposed a solution for pathological tissue cutting equipment. Summary of the invention

[0003] In view of the above background technology, it is pointed out that the current pathological tissue slicer is not able to fix the tissue sufficiently when slicing living tissue, and the tissue is displaced when cutting. There are several small cracks or fissures in uncertain positions on the slice, so a technical solution of a pathological tissue cutting device is provided.

[0004] It includes a slicing mechanism, a pathological tissue placement table is arranged on the front area of ​​the top surface of the slicing mechanism, two pathological tissue flexible clamps are movably arranged on the top surface of the pathological tissue placement table, and a pathological tissue cooling system is fixedly connected to the bottom surface of the pathological tissue placement table;

[0005] The slicing mechanism includes two bases arranged on the left and right, a bottom plate fixed to the upper surface of the base, and a shell fixed to the right side of the rear surface of the bottom plate, a saw blade driver is fixedly connected to the rear side of the shell, and a cutting saw blade adapted to the saw blade driver is arranged on the front side of the shell;

[0006] The pathological tissue flexible clamp includes a hanging plate, a U-shaped bracket fixed to the rear side of the hanging plate, and two half-circle gears connected to the front side of the U-shaped bracket in a left-right mirror-symmetrical rotation. A servo motor is installed on the bottom surface of the hanging plate, and the output shaft of the servo motor is connected to a driving gear through a coupling. Specifically, before cutting the pathological tissue, the servo motor and the driving gear drive the half-circle gear to rotate, and the pulling rod is opened outward, forcing the clamping arms to open outward away from each other, and the pathological tissue is placed between the clamping arms. After the servo motor rotates in the opposite direction to clamp the pathological tissue, the slider on the electric control rail is moved back and forth to allow the pathological tissue to contact the feeding guide plate. If the pathological tissue is small, the slider is moved closer or farther away from each other on the electric control rail before clamping the pathological tissue to adjust the size of the pathological tissue.

[0007] The pathological tissue placement table includes a movable block slidably arranged on the upper surface of a bottom plate, a movable plate fixed on the upper surface of the movable block, and a side vertical plate fixedly connected to the left side of the upper surface of the movable plate, the top surface of the side vertical plate is fixedly connected to an electric control guide rail, two sliders are movably arranged on the track of the electric control guide rail, and a support plate is fixed on the top of each slider, and the end of the support plate away from the slider is fixedly connected to the front side surface of the hanging plate; specifically, the pathological tissue to be cut is placed on the upper surface of the movable plate, the rear end of the tissue is allowed to contact the front surface of the feeding guide plate, and the feeding guide plate is pulled forward or backward by adjusting the rotation of the screw rod, so that after the cutting saw blade is driven by the saw blade driving machine, the forward and backward moving distance of the feeding guide plate controls the slice thickness of the tissue.

[0008] The pathological tissue cooling system includes a shell fixed on the left side of the movable block, a fan fixed in the inner cavity of the shell, and a rectangular frame fixed on the upper surface of the shell, a heat-conducting coil is fixedly connected to the inside of the rectangular frame, a vortex tube is horizontally passed through the inside of the heat-conducting coil, and a servo air pump matched with the vortex tube is fixedly connected to the front surface of the rectangular frame. Specifically, when the movable plate slides left and right on the slideway by the movable block for slicing, the servo air pump provides flowing air to the inside of the vortex tube, and the low temperature is transferred to the heat-conducting coil after being cooled by the vortex tube. Since the upper surface of the heat-conducting coil is in contact with the bottom of the movable plate, and the pathological tissue is placed on the movable plate, the wax embedded in the pathological tissue is affected by the low temperature and solidifies, thereby preventing cracks or cracks from appearing on the sample after slicing.

[0009] In the technical solution of the above-mentioned pathological tissue cutting device, preferably: a threaded hole adapted to the adjusting screw is opened in the middle position inside the support seat, circular holes for the guide column to pass through are opened on the left and right sides inside the support seat, and a through hole for the adjusting screw to pass through is opened inside the L-shaped fixing plate.

[0010] In the technical solution of the above-mentioned pathological tissue cutting equipment, preferably: the rear surface of the base on the left side is fixedly connected with an L-shaped fixing plate, the rear surface of the L-shaped fixing plate is fixed with two guide columns, the outer ring surface of the guide column is fixed with a support seat, an adjusting screw rod is rotatably penetrated inside the support seat, the front end of the adjusting screw rod is rotatably connected with a feeding guide plate, and the front end of the guide column is fixedly connected to the rear surface of the feeding guide plate.

[0011] In the technical solution of the above-mentioned pathological tissue cutting equipment, preferably: a slideway is provided on the front and rear surfaces of the base plate, a slide rod inserted into the slideway for sliding is fixed on the inner surface of the movable block, and a rectangular through hole is provided on the top surface of the base plate for the pathological tissue cooling system to move left and right.

[0012] In the above-mentioned technical solution of the pathological tissue cutting device, preferably: the bottom surface of the movable plate contacts the upper end surface of the heat-conducting coil, the top surface of the side vertical plate is fixedly connected to an electric control rail, and the bottom surface of the electric control rail is connected to the top surface of the electric control rail by screw locking.

[0013] In the above-mentioned technical solution of the pathological tissue cutting device, preferably: the driving gear is meshed with the half-circle gear on the left, the two half-circle gears are meshed with each other, a pulling rod is fixed to the bottom of the outer circle of each half-circle gear, and a clamping arm is hinged on one section of the pulling rod.

[0014] In the technical solution of the above-mentioned pathological tissue cutting device, preferably: pressure sensors are installed on the surfaces of the sides of the clamping arms close to each other, and a limiting arm is hinged between the middle section of the sides of the clamping arms close to each other and the bottom end of the U-shaped bracket.

[0015] In the above-mentioned technical solution of the pathological tissue cutting device, preferably: the front side surface of the U-shaped bracket is rotationally connected to the rear end face of the driving gear, and both sides of the interior of the U-shaped bracket are provided with shaft pins passing through the half-circle gear for the half-circle gear to rotate.

[0016] In the above technical solution of the pathological tissue cutting device, preferably: an axle pin is provided between the ends of the pulling rod and the clamping arm close to each other, so as to allow the pulling rod and the clamping arm to rotate relative to each other.

[0017] In the above technical solution of the pathological tissue cutting device, preferably: the inner middle section of the clamping arm and the bottom of the U-shaped bracket are respectively provided with axle pins penetrating the upper and lower ends of the limiting arm.

[0018] It can be seen from the above technical solution that the present invention provides a pathological tissue cutting device. Compared with the prior art, the present invention has the following beneficial effects:

[0019] In the technical solution of the present invention, a group of flexible clamps are arranged on the working surface of the pathological tissue slicer, which can stabilize the posture of the pathological tissue without causing excessive pressure on the pathological tissue. A cooling system is also arranged on the working surface of the pathological tissue slicer to prevent the temperature of the wax block wrapping the pathological tissue from being too high, and to cool the wax block to avoid cracks in the slices. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces and describes the drawings required for use in the embodiments of the present invention or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention, and for ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0021] Figure 1 It is an overall schematic diagram of the pathological tissue sectioning instrument;

[0022] Figure 2 It is the exploded diagram of the slicing mechanism;

[0023] Figure 3 Schematic diagram of the table for pathological tissue placement;

[0024] Figure 4 Schematic diagram of the cooling system for pathological tissue;

[0025] Figure 5 Schematic diagram of the flexible clamp for pathological tissue.

[0026] Attached Figure 1 -Attached Figure 5 The corresponding relationship of the parts is as follows:

[0027] 1. Slicing mechanism; 11. Base; 12. Cutting saw blade; 13. Shell; 14. Saw blade driver; 15. Adjusting screw rod; 16. Support seat; 17. Guide column; 18. L-shaped fixing plate; 19. Feeding guide plate; 110. Slideway; 111. Rectangular through hole; 112. Bottom plate; 2. Pathological tissue flexible clamp; 21. Hanging plate; 22. U-shaped bracket; 23. Half-circle gear; 24. Pulling rod; 25. Clamping arm; 26. Limiting arm; 27. Servo motor; 28. Driving gear; 3. Pathological tissue placement table; 31. Movable plate; 32. Side vertical plate; 33. Electric control guide rail; 34. Slider; 35. Support plate; 36. Movable block; 4. Pathological tissue cooling system; 41. Shell; 42. Fan; 43. Vortex tube; 44. Heat transfer coil; 45. Rectangular frame; 46. Servo air pump. DETAILED DESCRIPTION

[0028] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described below are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0029] In order to more clearly explain and illustrate the technical solution and implementation of the present invention, several preferred specific embodiments for implementing the technical solution of the present invention are introduced below.

[0030] Embodiment: A preferred technical solution of a pathological tissue cutting device:

[0031] Refer to the instruction manual Figure 1 As shown: it includes a slicing mechanism 1, a pathological tissue placement table 3 is arranged on the front area of ​​the top surface of the slicing mechanism 1, two pathological tissue flexible clamps 2 are movably arranged on the top surface of the pathological tissue placement table 3, and a pathological tissue cooling system 4 is fixedly connected to the bottom surface of the pathological tissue placement table 3;

[0032] Refer to the instruction manual Figure 2 As shown: the slicing mechanism 1 includes two bases 11 arranged on the left and right, a bottom plate 112 fixed to the upper surface of the base 11, and a housing 13 fixed to the right side of the rear surface of the bottom plate 112, a saw blade driver 14 is fixedly connected to the rear side of the housing 13, and a cutting saw blade 12 adapted to the saw blade driver 14 is arranged on the front side of the housing 13;

[0033] Refer to the instruction manual Figure 5 As shown: the pathological tissue flexible clamp 2 includes a hanging plate 21, a U-shaped bracket 22 fixed to the rear side of the hanging plate 21, and two half-circle gears 23 connected to the front side of the U-shaped bracket 22 in a left-right mirror-symmetrical rotation. A servo motor 27 is installed on the bottom surface of the hanging plate 21, and the output shaft of the servo motor 27 is connected to a driving gear 28 through a coupling;

[0034] Refer to the instruction manual Figure 3 As shown: the pathological tissue placement table 3 includes a movable block 36 slidably arranged on the upper surface of the bottom plate 112, a movable plate 31 fixed on the upper surface of the movable block 36, and a side vertical plate 32 fixedly connected to the left side of the upper surface of the movable plate 31, the top surface of the side vertical plate 32 is fixedly connected to an electric control guide rail 33, and two sliders 34 are movably arranged on the track of the electric control guide rail 33, and a support plate 35 is fixed on the top of each slider 34, and the end of the support plate 35 away from the slider 34 is fixedly connected to the front side surface of the hanging plate 21;

[0035] Refer to the instruction manual Figure 4 As shown: the pathological tissue cooling system 4 includes a shell 41 fixed on the left side of the movable block 36, a fan 42 fixed in the inner cavity of the shell 41, and a rectangular frame 45 fixed on the upper surface of the shell 41, a heat-conducting coil 44 is fixedly connected to the interior of the rectangular frame 45, a vortex tube 43 is horizontally penetrated inside the heat-conducting coil 44, and a servo air pump 46 that cooperates with the vortex tube 43 is fixedly connected to the front surface of the rectangular frame 45.

[0036] Refer to the instruction manual Figure 2As shown: a threaded hole adapted to the adjusting screw 15 is provided in the middle of the support seat 16, round holes for the guide column 17 to pass through are provided on both the left and right sides of the support seat 16, and a through hole for the adjusting screw 15 to pass through is provided in the L-shaped fixing plate 18. The rear surface of the left base 11 is fixedly connected with the L-shaped fixing plate 18, the rear surface of the L-shaped fixing plate 18 is fixed with two guide columns 17, the outer surface of the guide column 17 is fixed with a support seat 16, an adjusting screw 15 is rotatably passed through the support seat 16, the front end of the adjusting screw 15 is rotatably connected with the feeding guide plate 19, and the front end of the guide column 17 is fixedly connected with the rear surface of the feeding guide plate 19.

[0037] Refer to the instruction manual Figure 2 As shown: a slideway 110 is provided on the front and rear surfaces of the bottom plate 112, a slide bar inserted into the slideway 110 for sliding is fixed on the inner surface of the movable block 36, and a rectangular through hole 111 is provided on the top surface of the bottom plate 112 for the pathological tissue cooling system 4 to move left and right. The bottom surface of the movable plate 31 contacts the upper end surface of the heat conducting coil 44, and an electric control rail 33 is fixedly connected to the top surface of the side vertical plate 32, and the bottom surface of the electric control rail 33 is locked and connected to the top surface of the electric control rail 33 by screws.

[0038] Refer to the instruction manual Figure 5 As shown in the figure: the driving gear 28 is meshed with the left half-circle gear 23, and the two half-circle gears 23 are meshed with each other. A pulling rod 24 is fixed to the bottom of the outer circle of each half-circle gear 23, and a clamping arm 25 is hinged to a section of the pulling rod 24. A pressure sensor is installed on the surface of the clamping arm 25 on the side close to each other, and a limit arm 26 is hinged between the middle section of the side close to each other and the bottom end of the U-shaped bracket 22. The front side surface of the U-shaped bracket 22 is rotatably connected to the rear end surface of the driving gear 28, and shaft pins penetrating the half-circle gear 23 are arranged on both sides of the interior of the U-shaped bracket 22 for the half-circle gear 23 to rotate. An shaft pin is arranged between the end of the pulling rod 24 and the clamping arm 25 close to each other, for the pulling rod 24 and the clamping arm 25 to rotate with each other. The inner middle section of the clamping arm 25 and the bottom of the U-shaped bracket 22 are respectively provided with shaft pins penetrating the upper and lower ends of the limit arm 26.

[0039] According to the above-mentioned preferred technical solution, the workflow of the technical solution is described as follows:

[0040] The pathological tissue to be cut is placed on the upper surface of the movable plate 31, and the rear end of the tissue is contacted with the front surface of the feed guide plate 19. The feed guide plate 19 is pulled forward or backward by adjusting the rotation of the screw rod 15, so that after the cutting saw blade 12 is driven by the saw blade driver 14, the forward and backward movement distance of the feed guide plate 19 controls the thickness of the tissue slice.

[0041] When the movable plate 31 slides left and right on the slide 110 by means of the movable block 36 for slicing, the servo air pump 46 provides flowing air to the inside of the vortex tube 43, and the low temperature is transferred to the heat-conducting coil 44 after being cooled by the vortex tube 43. Since the upper surface of the heat-conducting coil 44 is in contact with the bottom of the movable plate 31, and the pathological tissue is placed on the movable plate 31, the wax embedded in the pathological tissue is solidified by the low temperature, thereby preventing cracks or cracks from appearing on the sample after slicing.

[0042] Before cutting the pathological tissue, the servo motor 27 and the driving gear 28 drive the half-circle gear 23 to rotate, and the pulling rod 24 is opened outward, forcing the clamping arms 25 to open outward away from each other, and at this time, the pathological tissue is placed between the clamping arms 25. After the servo motor 27 rotates in the opposite direction to clamp the pathological tissue, the slider 34 on the electric control guide rail 33 is moved back and forth to make the pathological tissue contact with the feeding guide plate 19. If the pathological tissue is small, the slider 34 is moved closer or farther away from each other on the electric control guide rail 33 before clamping the pathological tissue to adjust the size of the pathological tissue.

[0043] The present invention is not limited to the above-mentioned optimal implementation mode. Anyone should be aware that any structural changes made under the inspiration of the present invention, and any technical solutions that are the same or similar to the present invention, fall within the protection scope of the present invention. Finally, it should be noted that the structures, proportions, sizes, etc. illustrated in the drawings of this specification are only used to match the contents disclosed in the specification for people familiar with this technology to understand and read, and are not used to limit the restrictive conditions that can be implemented in this application, so they have no technical substantive significance. Any structural modification, change in proportional relationship or adjustment of size, without affecting the effects that can be produced by this application and the purposes that can be achieved, should still fall within the scope that can be covered by the technical content disclosed in this application.

Claims

1. A pathological tissue cutting device, comprising a slicing mechanism (1), characterized in that: A pathological tissue placement table (3) is arranged in the front area of ​​the top surface of the slicing mechanism (1), two pathological tissue flexible clamps (2) are movably arranged on the top surface of the pathological tissue placement table (3), and a pathological tissue cooling system (4) is fixedly connected to the bottom surface of the pathological tissue placement table (3); The slicing mechanism (1) comprises two bases (11) arranged on the left and right, a bottom plate (112) fixed to the upper surface of the base (11), and a housing (13) fixed to the right side of the rear surface of the bottom plate (112); a saw blade driver (14) is fixedly connected to the rear side of the housing (13), and a cutting saw blade (12) adapted to the saw blade driver (14) is arranged on the front side of the housing (13); The pathological tissue flexible clamp (2) comprises a hanging plate (21), a U-shaped bracket (22) fixed to the rear side of the hanging plate (21), and two half-circle gears (23) connected to the front side of the U-shaped bracket (22) in a mirror-symmetrical manner. A servo motor (27) is installed on the bottom surface of the hanging plate (21), and the output shaft of the servo motor (27) is connected to a driving gear (28) via a coupling. The pathological tissue placement table (3) comprises a movable block (36) slidably arranged on the upper surface of the bottom plate (112), a movable plate (31) fixed on the upper surface of the movable block (36), and a side vertical plate (32) fixedly connected to the left side of the upper surface of the movable plate (31); the top surface of the side vertical plate (32) is fixedly connected to an electric control rail (33); two sliders (34) are movably arranged on the track of the electric control rail (33); a support plate (35) is fixed on the top of each slider (34); and the end of the support plate (35) away from the slider (34) is fixedly connected to the front side surface of the hanging plate (21); The pathological tissue cooling system (4) comprises a shell (41) fixed on the left side of the movable block (36), a fan (42) fixed in the inner cavity of the shell (41), and a rectangular frame (45) fixed on the upper surface of the shell (41); a heat conducting coil (44) is fixedly connected to the interior of the rectangular frame (45); a vortex tube (43) is horizontally penetrated inside the heat conducting coil (44); and a servo air pump (46) cooperating with the vortex tube (43) is fixedly connected to the front surface of the rectangular frame (45).

2. A pathological tissue cutting device according to claim 1, characterized in that: A threaded hole adapted to the adjusting screw rod (15) is provided in the middle of the support seat (16), circular holes for the guide column (17) to pass through are provided on both left and right sides of the support seat (16), and a through hole for the adjusting screw rod (15) to pass through is provided in the L-shaped fixing plate (18).

3. A pathological tissue cutting device according to claim 1, characterized in that: The rear surface of the left base (11) is fixedly connected to an L-shaped fixing plate (18), and two guide columns (17) are fixed to the rear surface of the L-shaped fixing plate (18). A support seat (16) is fixed to the outer ring surface of the guide column (17), and an adjusting screw rod (15) is rotatably passed through the interior of the support seat (16). The front end of the adjusting screw rod (15) is rotatably connected to a feeding guide plate (19), and the front end of the guide column (17) is fixedly connected to the rear surface of the feeding guide plate (19).

4. A pathological tissue cutting device according to claim 1, characterized in that: The front and rear surfaces of the bottom plate (112) are each provided with a slideway (110), the inner surface of the movable block (36) is fixed with a slide rod inserted into the slideway (110) for sliding, and the top surface of the bottom plate (112) is provided with a rectangular through hole (111) for allowing the pathological tissue cooling system (4) to move left and right.

5. The pathological tissue cutting device according to claim 1, characterized in that: The bottom surface of the movable plate (31) contacts the upper end surface of the heat-conducting coil (44), the top surface of the side vertical plate (32) is fixedly connected to an electric control rail (33), and the bottom surface of the electric control rail (33) is fastened to the top surface of the electric control rail (33) by screws.

6. A pathological tissue cutting device according to claim 1, characterized in that: The driving gear (28) is meshed with the half-circle gear (23) on the left, and the two half-circle gears (23) are meshed with each other. A pulling rod (24) is fixed to the bottom of the outer circle of each half-circle gear (23), and a clamping arm (25) is hinged to a section of the pulling rod (24).

7. The pathological tissue cutting device according to claim 1, characterized in that: Pressure sensors are installed on the surfaces of the clamping arms (25) on the sides close to each other, and a limiting arm (26) is hingedly connected between the middle section of the clamping arms (25) on the sides close to each other and the bottom end of the U-shaped bracket (22).

8. The pathological tissue cutting device according to claim 1, characterized in that: The front side surface of the U-shaped bracket (22) is rotatably connected to the rear end surface of the driving gear (28), and shaft pins penetrating the half-circle gear (23) are arranged on both sides of the interior of the U-shaped bracket (22) for rotating the half-circle gear (23).

9. The pathological tissue cutting device according to claim 1, characterized in that: An axle pin is provided between the ends of the pulling rod (24) and the clamping arm (25) that are close to each other, and is used for the pulling rod (24) and the clamping arm (25) to rotate relative to each other.

10. The pathological tissue cutting device according to claim 1, characterized in that: The inner middle section of the clamping arm (25) and the bottom of the U-shaped bracket (22) are respectively provided with axle pins penetrating the upper and lower ends of the limiting arm (26).