Full-automatic immunohistochemical dyeing machine

Abstract

The invention discloses a full-automatic immunohistochemical dyeing machine, and relates to the technical field of medical instruments, the full-automatic immunohistochemical dyeing machine comprises a machine body, the interior of the machine body is rotatably connected with a rotating frame, the middle of the rotating frame is rotatably connected with a column body, the middle of the column body is fixedly provided with a layer plate, and the interior of the column body is fixedly provided with a horizontal spring and a fixed plate; a trigger ball is fixed to the other end, opposite to the column body, of the horizontal spring, a pressure sensor is fixed to the surface of the fixed plate, and a conduction pad is fixed to the other end, opposite to the fixed plate, of the pressure sensor. The dyeing assembly is used for dyeing samples in the shelf, the rotating motor drives the shelf to rotate through the rotating frame, and therefore the dyeing speed is increased, the frequency of replacing dyeing discs on the surface of the shelf is reduced, the horizontal column detects the rotating angle of the shelf, the driving motor changes the position of a movable disc and adjusts the gravity center, and the shelf is kept horizontal.

Description

Technical Field

[0001] The invention relates to the technical field of medical devices, and in particular to a full-automatic immunohistochemical staining machine. Background Art

[0002] A fully automatic immunohistochemical staining machine disclosed in the Chinese patent application number CN 113075008 A comprises a staining machine body, a housing is fixedly arranged on the staining machine body, an upper axis moving mechanism, a middle axis moving mechanism and a lower axis moving mechanism are arranged on the housing, the upper axis moving mechanism comprises an upper slider moving along the X-axis direction, an upper driving mechanism for driving the upper slider to move along the X-axis is arranged on the housing; the middle axis moving mechanism comprises a middle slider moving along the Y-axis direction, a middle driving mechanism for driving the middle slider to move along the Y-axis is arranged on the upper slider; the lower axis moving mechanism is arranged on the middle slider, the lower axis moving mechanism comprises a lower output rod moving along the Z-axis direction, a sample adding needle is fixedly arranged on the lower output rod, and a lower driving mechanism for driving the lower output rod to move along the Z-axis is arranged on the middle slider; by using one motor, the effect of driving the sample adding needle to move along the Y-axis and Z-axis directions respectively can be achieved, thereby reducing the configuration of the mechanism to a certain extent.

[0003] However, in this patent, a single motor is used to drive the dual-axis movement, which requires the switching mechanism to be engaged, which increases the reaction time of the motor drive and reduces the efficiency of staining. Therefore, a fully automatic immunohistochemical staining machine is proposed to solve the above problems. Summary of the invention

[0004] The present invention provides a fully automatic immunohistochemical staining machine, which solves the above technical problems.

[0005] To solve the above technical problems, the present invention provides a fully automatic immunohistochemical staining machine, comprising a body, a rotating frame rotatably connected inside the body, a column rotatably connected in the middle of the rotating frame, a layer plate fixed in the middle of the column, a horizontal spring and a fixed plate fixed inside the column, a trigger ball fixed at the other end of the horizontal spring relative to the column, a pressure sensor fixed on the surface of the fixed plate, a conduction pad fixed at the other end of the pressure sensor relative to the fixed plate, a micro switch fixed at the other end of the conduction pad relative to the pressure sensor, the other end of the micro switch relative to the conduction pad faces the trigger ball, a connecting frame is connected to the bottom of the layer plate, a driving motor is fixed on the surface of the connecting frame, a transmission shaft is transmission-connected to the surface of the driving motor, a moving disk is rotationally connected to the surface of the transmission shaft through a thread, a guide column is fixed at the bottom of the layer plate, the moving disk is slidably connected to the guide column, and a staining assembly is provided at the upper end of the body.

[0006] Preferably, a power frame and a guide frame are fixed to the side of the machine body, the surface of the power frame is connected to a longitudinal moving motor through a transmission, and the internal parts of the guide frame and the power frame are connected to an auxiliary moving frame through a transmission.

[0007] Preferably, a transverse moving motor is fixed inside the auxiliary moving frame, the upper end of the transverse moving motor is transmission-connected to a power wheel, and the surface of the power wheel is transmission-connected to a driving belt.

[0008] Preferably, a belt clamp is fixed to the surface of the driving belt, a base plate is fixed to the lower end of the belt clamp, a lifting motor is fixed to the surface of the base plate, a lifting screw is transmission-connected to the upper end of the lifting motor, a lifting plate is threadedly connected to the surface of the lifting screw, and a dyeing assembly is fixed inside the lifting plate.

[0009] Preferably, a limiting column is fixed to the lower end of the lifting plate, a groove is provided on the surface of the bottom plate, and the limiting column is slidably connected to the groove.

[0010] Preferably, a positioning plate is fixed on the inner surface of the body, an electric push rod is fixed inside the positioning plate, and an extrusion block is fixed to the other end of the electric push rod opposite to the positioning plate.

[0011] Preferably, a straight column is fixed on the surface of the extrusion block, a deep groove is provided on the surface of the positioning plate, and the straight column is slidably connected to the deep groove.

[0012] Preferably, a transmission box is fixed on the outer surface of the body, a rotating motor is transmission-connected to the surface of the transmission box, and the transmission box is transmission-connected to the rotating frame.

[0013] Preferably, an elastic ring is fixed between the positioning plate and the extrusion block, and the elastic ring is made of elastic material.

[0014] Compared with the related art, the fully automatic immunohistochemical staining machine provided by the present invention has the following beneficial effects:

[0015] 1. The present invention changes the position of the dyeing assembly by means of a longitudinal moving motor, a transverse moving motor and a lifting motor. The dyeing assembly dyes the samples inside the shelf. The rotating motor drives the shelf to rotate through the rotating frame, thereby accelerating the dyeing speed and reducing the frequency of replacing the dyeing disk on the surface of the shelf. The horizontal column detects the angle of the shelf when it rotates, drives the motor to change the position of the moving disk, and adjusts the center of gravity to keep the shelf level.

[0016] 2. The present invention starts the electric push rod to drive the extrusion block to move, the elastic ring is deformed, and the extrusion block squeezes the shelf, thereby fixing the position of the shelf. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is the main structure diagram of the present invention;

[0018] Figure 2 It is a cutaway structural diagram of the machine body in the present invention;

[0019] Figure 3 is a structural diagram of the rotating frame of the present invention;

[0020] Figure 4 It is a cross-sectional structural diagram of the horizontal column in the present invention;

[0021] Figure 5 It is a structural diagram of the middle frame of the present invention;

[0022] Figure 6 It is a side structural diagram of the middle shelf of the present invention;

[0023] Figure 7 It is a structural diagram of the limiting plate in the present invention;

[0024] Figure 8 It is a cross-sectional structural diagram of the limiting plate in the present invention;

[0025] Fig. 9 It is a side structural diagram of the lifting device in the present invention.

[0026] Numbers in the figure: 1, guide frame; 2, power wheel; 3, horizontal moving motor; 4, machine body; 5, limit plate; 6, shelf; 7, transmission box; 8, rotating motor; 9, auxiliary moving frame; 10, power frame; 11, longitudinal moving motor; 12, horizontal column; 13, rotating frame; 121, column; 122, fixed plate; 123, pressure sensor; 124, conductive pad; 125, micro switch; 126, trigger ball; 127, horizontal spring; 61 , layer plate; 62, connecting frame; 63, transmission shaft; 64, driving motor; 65, moving plate; 66, guide column; 67, motor frame; 51, positioning plate; 52, elastic ring; 53, extrusion block; 54, electric push rod; 55, guide column; 14, driving belt; 15, lifting device; 151, lifting plate; 152, limiting column; 153, dyeing assembly; 154, bottom plate; 155, lifting motor; 156, lifting screw; 157, belt clamp. DETAILED DESCRIPTION

[0027] Embodiment 1, by Figure 1-9The present invention includes a fully automatic immunohistochemical staining machine, including a machine body 4, a rotating frame 13 is rotatably connected inside the machine body 4, a column 121 is rotatably connected in the middle of the rotating frame 13, a layer plate 61 is fixed in the middle of the column 121, a horizontal spring 127 and a fixed plate 122 are fixed inside the column 121, a trigger ball 126 is fixed at the other end of the horizontal spring 127 relative to the column 121, a pressure sensor 123 is fixed on the surface of the fixed plate 122, and a conductive pad 124 is fixed at the other end of the pressure sensor 123 relative to the fixed plate 122. A micro switch 125 is fixed to the other end of the pad 124 relative to the pressure sensor 123, and the other end of the micro switch 125 relative to the conductive pad 124 faces the trigger ball 126. A connecting frame 62 is connected to the bottom of the layer plate 61, and a driving motor 64 is fixed to the surface of the connecting frame 62. The surface of the driving motor 64 is transmission-connected to a transmission shaft 63, and the surface of the transmission shaft 63 is rotationally connected to a moving disk 65 through a thread. A guide column 66 is fixed to the bottom of the layer plate 61, and the moving disk 65 is slidably connected to the guide column 66. A dyeing assembly 153 is provided at the upper end of the body 4.

[0028] A power frame 10 and a guide frame 1 are fixed to the side of the machine body 4 . The surface of the power frame 10 is connected to a longitudinal moving motor 11 through transmission. The insides of the guide frame 1 and the power frame 10 are connected to an auxiliary moving frame 9 through transmission.

[0029] A lateral moving motor 3 is fixed inside the auxiliary moving frame 9 , the upper end of the lateral moving motor 3 is transmission-connected to a power wheel 2 , and the surface of the power wheel 2 is transmission-connected to a driving belt 14 .

[0030] A belt clamp 157 is fixed to the surface of the driving belt 14, a base plate 154 is fixed to the lower end of the belt clamp 157, a lifting motor 155 is fixed to the surface of the base plate 154, a lifting screw 156 is transmission-connected to the upper end of the lifting motor 155, a lifting plate 151 is threadedly connected to the surface of the lifting screw 156, and a dyeing assembly 153 is fixed inside the lifting plate 151.

[0031] A limiting column 152 is fixed to the lower end of the lifting plate 151 , and a groove is provided on the surface of the bottom plate 154 , and the limiting column 152 is slidably connected to the groove.

[0032] Start the longitudinal moving motor 11 to drive the auxiliary moving frame 9 to move, the transverse moving motor 3 rotates to drive the power wheel 2 to rotate, the power wheel 2 drives the driving belt 14 to rotate, the rotating driving belt 14 changes the position of the belt clamp 157, the belt clamp 157 drives the bottom plate 154 to move, the bottom plate 154 drives the lifting motor 155 to move, the lifting motor 155 drives the lifting plate 151 to move through the lifting screw 156, thereby driving the dyeing assembly 153 to move, the dyeing assembly 153 moves to the top of the position where dyeing is required, start the lifting motor 155 to drive the lifting screw 156 to rotate, the rotating lifting screw 156 changes the height of the lifting plate 151, the limiting column 152 slides inside the bottom plate 154, and the dyeing assembly 153 dyes the inside of the shelf 6.

[0033] After the dyeing of a single shelf 6 is completed, the shelf 6 is rotated, and the shelf 6 rotates relative to the rotating frame 13. When the shelf 6 deflects itself during rotation and cannot maintain a horizontal position, the trigger ball 126 moves inside the column 121 under the influence of gravity, and the trigger ball 126 is squeezed on the surface of the micro switch 125. The micro switch 125 is turned on, and the micro switch 125 moves through the conductive pad 124 to squeeze the pressure sensor 123. The pressure sensor 123 is subjected to pressure, and the micro switch 125 starts the drive motor 64. The drive motor 64 drives the transmission shaft 63 to rotate. The transmission shaft 63 changes the position of the movable disk 65 through the thread. The movable disk 65 slides on the surface of the guide column 66 to change the center of gravity position of the shelf 61 and help the shelf 6 to return to the center. According to the trigger time of the micro switch 125 and the pressure value of the pressure sensor 123, the speed and start time of the drive motor 64 are changed. After the dyeing of the shelf 6 is completed, the dyeing plate on the surface of the shelf 6 is removed from the rear of the machine body 4.

[0034] Embodiment 2, by Figure 1-9 The present invention includes a fully automatic immunohistochemical staining machine, including a machine body 4, a rotating frame 13 is rotatably connected inside the machine body 4, a column 121 is rotatably connected in the middle of the rotating frame 13, a layer plate 61 is fixed in the middle of the column 121, a horizontal spring 127 and a fixed plate 122 are fixed inside the column 121, a trigger ball 126 is fixed at the other end of the horizontal spring 127 relative to the column 121, a pressure sensor 123 is fixed on the surface of the fixed plate 122, and a conductive pad 124 is fixed at the other end of the pressure sensor 123 relative to the fixed plate 122. A micro switch 125 is fixed to the other end of the pad 124 relative to the pressure sensor 123, and the other end of the micro switch 125 relative to the conductive pad 124 faces the trigger ball 126. A connecting frame 62 is connected to the bottom of the layer plate 61, and a driving motor 64 is fixed to the surface of the connecting frame 62. The surface of the driving motor 64 is transmission-connected to a transmission shaft 63, and the surface of the transmission shaft 63 is rotationally connected to a moving disk 65 through a thread. A guide column 66 is fixed to the bottom of the layer plate 61, and the moving disk 65 is slidably connected to the guide column 66. A dyeing assembly 153 is provided at the upper end of the body 4.

[0035] A positioning plate 51 is fixed on the inner surface of the body 4 , an electric push rod 54 is fixed inside the positioning plate 51 , and an extrusion block 53 is fixed to the other end of the electric push rod 54 opposite to the positioning plate 51 .

[0036] A straight column 55 is fixed on the surface of the extrusion block 53 , and a deep groove is provided on the surface of the positioning plate 51 , and the straight column 55 is slidably connected to the deep groove.

[0037] An elastic ring 52 is fixed between the positioning plate 51 and the extrusion block 53 , and the elastic ring 52 is made of elastic material.

[0038] When the shelf 6 moves to the top and reaches a predetermined position, the electric push rod 54 starts to drive the squeezing block 53 to move, the elastic ring 52 is deformed, and the squeezing block 53 squeezes the shelf 6, thereby fixing the position of the shelf 6.

[0039] Embodiment 3, by Figure 1-9 The present invention includes a fully automatic immunohistochemical staining machine, including a machine body 4, a rotating frame 13 is rotatably connected inside the machine body 4, a column 121 is rotatably connected in the middle of the rotating frame 13, a layer plate 61 is fixed in the middle of the column 121, a horizontal spring 127 and a fixed plate 122 are fixed inside the column 121, a trigger ball 126 is fixed at the other end of the horizontal spring 127 relative to the column 121, a pressure sensor 123 is fixed on the surface of the fixed plate 122, and a conductive pad 124 is fixed at the other end of the pressure sensor 123 relative to the fixed plate 122. A micro switch 125 is fixed to the other end of the pad 124 relative to the pressure sensor 123, and the other end of the micro switch 125 relative to the conductive pad 124 faces the trigger ball 126. A connecting frame 62 is connected to the bottom of the layer plate 61, and a driving motor 64 is fixed to the surface of the connecting frame 62. The surface of the driving motor 64 is transmission-connected to a transmission shaft 63, and the surface of the transmission shaft 63 is rotationally connected to a moving disk 65 through a thread. A guide column 66 is fixed to the bottom of the layer plate 61, and the moving disk 65 is slidably connected to the guide column 66. A dyeing assembly 153 is provided at the upper end of the body 4.

[0040] A transmission box 7 is fixed on the outer surface of the body 4 , and a rotating motor 8 is transmission-connected to the surface of the transmission box 7 , and the transmission box 7 is transmission-connected to the rotating frame 13 .

[0041] The rotating motor 8 drives the rotating frame 13 to rotate through the transmission box 7, and the rotation of the rotating frame 13 drives the layer frame 6 to rotate.

[0042] Working principle: start the longitudinal moving motor 11 to drive the auxiliary moving frame 9 to move, the transverse moving motor 3 rotates to drive the power wheel 2 to rotate, the power wheel 2 drives the driving belt 14 to rotate, the rotating driving belt 14 changes the position of the belt clamp 157, the belt clamp 157 drives the bottom plate 154 to move, the bottom plate 154 drives the lifting motor 155 to move, the lifting motor 155 drives the lifting plate 151 to move through the lifting screw 156, thereby driving the dyeing assembly 153 to move, the dyeing assembly 153 moves to the position directly above the position where dyeing is required, start the lifting motor 155 to drive the lifting screw 156 to rotate, the rotating lifting screw 156 changes the height of the lifting plate 151, the limiting column 152 slides inside the bottom plate 154, and the dyeing assembly 153 dyes the inside of the shelf 6.

[0043] After the dyeing of a single shelf 6 is completed, the rotating motor 8 drives the rotating frame 13 to rotate through the transmission box 7, and the rotation of the rotating frame 13 drives the shelf 6 to rotate, and the shelf 6 rotates relative to the rotating frame 13. When the shelf 6 deflects itself during rotation and cannot maintain a horizontal position, the trigger ball 126 moves inside the column 121 under the influence of gravity, and the trigger ball 126 is pressed on the surface of the micro switch 125. The micro switch 125 is turned on, and the micro switch 125 moves through the conductive pad 124 to squeeze the pressure sensor 123. The pressure sensor 123 is pressurized, and the micro switch 125 starts the drive motor 64, and the drive motor 64 drives the transmission shaft 6 3 rotates, the transmission shaft 63 changes the position of the moving plate 65 through the thread, the moving plate 65 slides on the surface of the guide column 66, changes the center of gravity position of the layer plate 61, and helps the layer shelf 6 to return to the right position. According to the triggering time of the micro switch 125 and the pressure value of the pressure sensor 123, the speed and starting time of the driving motor 64 are changed. When the layer shelf 6 moves to the top and reaches the predetermined position, the electric push rod 54 starts to drive the squeezing block 53 to move, the elastic ring 52 is deformed, and the squeezing block 53 squeezes the layer shelf 6, thereby fixing the position of the layer shelf 6; after the layer shelf 6 is dyed, the dyeing plate on the surface of the layer shelf 6 is removed from the rear of the machine body 4.

Claims

1. A fully automatic immunohistochemical staining machine, comprising a body (4), characterized in that: The body (4) is rotatably connected to a rotating frame (13) in the interior, the rotating frame (13) is rotatably connected to a column (121) in the middle, a layer plate (61) is fixed in the middle of the column (121), a horizontal spring (127) and a fixed plate (122) are fixed in the interior of the column (121), a trigger ball (126) is fixed to the other end of the horizontal spring (127) relative to the column (121), a pressure sensor (123) is fixed to the surface of the fixed plate (122), a conductive pad (124) is fixed to the other end of the pressure sensor (123) relative to the fixed plate (122), and the conductive pad (124) is relative to the pressure sensor (12 3) is fixed with a micro switch (125), the other end of the micro switch (125) is opposite to the other end of the conductive pad (124) and faces the trigger ball (126), the bottom of the layer plate (61) is connected with a connecting frame (62), the surface of the connecting frame (62) is fixed with a driving motor (64), the surface of the driving motor (64) is connected with a transmission shaft (63), the surface of the transmission shaft (63) is connected with a moving disk (65) by threaded rotation, the bottom of the layer plate (61) is fixed with a guide column (66), the moving disk (65) is connected to the guide column (66) in a sliding manner, and the upper end of the body (4) is provided with a dyeing assembly (153).

2. A fully automatic immunohistochemical staining machine according to claim 1, characterized in that: A power frame (10) and a guide frame (1) are fixed to the side of the machine body (4); the surface of the power frame (10) is connected to a longitudinal moving motor (11) through a transmission connection; and the guide frame (1) and the power frame (10) are connected to an auxiliary moving frame (9) through an internal transmission connection.

3. A fully automatic immunohistochemical staining machine according to claim 2, characterized in that: A transverse moving motor (3) is fixed inside the auxiliary moving frame (9), the upper end of the transverse moving motor (3) is drivingly connected to a power wheel (2), and the surface of the power wheel (2) is drivingly connected to a driving belt (14).

4. A fully automatic immunohistochemical staining machine according to claim 3, characterized in that: A belt clamp (157) is fixed on the surface of the driving belt (14); a bottom plate (154) is fixed at the lower end of the belt clamp (157); a lifting motor (155) is fixed on the surface of the bottom plate (154); a lifting screw (156) is transmission-connected to the upper end of the lifting motor (155); a lifting plate (151) is connected to the surface of the lifting screw (156) via a thread; a dyeing assembly (153) is fixed inside the lifting plate (151).

5. The fully automatic immunohistochemical staining machine according to claim 4, characterized in that: A limiting column (152) is fixed at the lower end of the lifting plate (151), and a groove is provided on the surface of the bottom plate (154), and the limiting column (152) is slidably connected to the groove.

6. The fully automatic immunohistochemical staining machine according to claim 1, characterized in that: A positioning plate (51) is fixed on the inner surface of the machine body (4), an electric push rod (54) is fixed inside the positioning plate (51), and an extrusion block (53) is fixed at the other end of the electric push rod (54) opposite to the positioning plate (51).

7. The fully automatic immunohistochemical staining machine according to claim 6, characterized in that: A straight column (55) is fixed on the surface of the extrusion block (53), a deep groove is provided on the surface of the positioning plate (51), and the straight column (55) is slidably connected to the deep groove.

8. The fully automatic immunohistochemical staining machine according to claim 1, characterized in that: A transmission box (7) is fixed on the outer surface of the machine body (4), a rotating motor (8) is drivingly connected to the surface of the transmission box (7), and the transmission box (7) is drivingly connected to a rotating frame (13).

9. The fully automatic immunohistochemical staining machine according to claim 6, characterized in that: An elastic ring (52) is fixed between the positioning plate (51) and the extrusion block (53), and the elastic ring (52) is made of elastic material.

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