Programmable full-spectrum skin video medical microscope

Abstract

The invention discloses a programmable full-spectrum skin video medical microscope, which belongs to the technical field of microscope detection, and comprises three cameras which are arranged on a camera mainboard side by side, one camera is a common camera, and the other two cameras are multispectral cameras; the light source can emit light with various wavelengths and is detachably mounted on the supporting seat; and the light path transmission unit is positioned between the light source and the cameras and is mounted on the supporting seat so as to transmit light emitted by the light source to the three cameras or one of the three cameras. The full-spectrum video medical microscope capable of programmably adjusting the receiving wavelength is provided by integrating a photoelectric technology and an artificial intelligence technology, so that various different application requirements from clinic to scientific research and spectrum requirements required by diagnosis of different skin disease spectrums are met; the method is suitable for detection and evaluation of skin with problems such as skin cancer, skin inflammation, skin quality and scalp.

Description

Technical Field

[0001] The invention belongs to the technical field of microscope detection, and in particular relates to a programmable full-spectrum skin video medical microscope. Background Art

[0002] Successful treatment of skin cancer depends on early diagnosis through biopsy. Prior to biopsy, the accuracy of screening to identify skin lesions as potentially malignant or benign depends primarily on the physician's experience. Clinical evaluation of potential lesions for skin cancer has historically been based primarily on visual features of suspected lesions (such as asymmetry, borders, color, size, and change over time), which can be analyzed by visual inspection of the lesion itself or images of the lesion.

[0003] In recent years, optical spectroscopy techniques have been explored as a method of differentiating between different tissue pathologies, including suspected cancerous lesions on the skin. These techniques may reduce the need for surgical excision of biopsy tissue samples. Instead, the tissue is analyzed spectroscopically by measurements and / or recordings obtained by an optical probe placed on or near the surface of the tissue to be tested. Real-time diagnosis of the tissue or assessment of its risk of malignancy may be attempted based on these measurements and / or recordings. Such spectroscopic techniques may include, but are not limited to, Raman spectroscopy, autofluorescence spectroscopy, fluorescence spectroscopy, reflectance spectroscopy, and elastic scattering spectroscopy (ESS).

[0004] In particular, the use of ESS alone or in combination with image analysis can improve the detection of potential skin cancers, providing sensitive data on underlying tissue changes. Classification algorithms can be applied to these data. Specifically, ESS is sensitive to the wavelength dependence of tissue optical scattering properties, which vary due to changes at the cellular and subcellular levels caused by different pathologies. These changes affect the measured spectral features and can be used to screen for melanoma and non-melanoma skin cancers.

[0005] Disadvantages of existing dermatoscopes: They only support polarized light and 10x magnification, and are not suitable in many scenarios. For example, they cannot use fluorescence to diagnose acne or use Wood's light to diagnose vitiligo. Summary of the invention

[0006] In order to solve the above problems, the present invention adopts the following technical solutions:

[0007] A programmable full-spectrum skin video medical microscope, comprising:

[0008] Three cameras are installed side by side on the camera mainboard, one of which is a normal camera and the other two are multispectral cameras;

[0009] A light source capable of emitting light of various wavelengths, wherein the light source is detachably mounted on a support base;

[0010] An optical path transmission unit is located between the light source and the camera and is installed on the support base to transmit the light emitted by the light source to the three cameras or one of the three cameras.

[0011] Furthermore, one of the two multispectral cameras is a multispectral camera capable of receiving VIS spectrum with a wavelength range of 500nm to 700nm; the other is a multispectral camera capable of receiving NIR spectrum with a wavelength range of 700nm to 900nm.

[0012] Furthermore, the optical path transmission unit includes a microscope objective, three beam splitters and three expanded-angle eyepieces, the microscope objective is detachably mounted on the support seat and is arranged corresponding to the light source; the three beam splitters and the three expanded-angle eyepieces are arranged in a one-to-one correspondence and are fixedly mounted on the support seat; the three expanded-angle eyepieces are arranged in a one-to-one correspondence with the three cameras; wherein the three beam splitters are arranged in sequence, and the multiple wavelengths of light emitted by the light source pass through the microscope objective and then pass through the three beam splitters in sequence, and the beam splitter transmits the corresponding object optical information to the corresponding camera through the expanded-angle eyepiece to realize imaging.

[0013] Furthermore, the optical path transmission unit includes a microscope objective, a folding device and an expanded angle eyepiece, the folding device is provided with a rotating shaft, and the rotating shaft is connected to the support seat in a damped rotation manner; three groups of reflectors are arranged in the folding device, and the three groups of reflectors are respectively arranged corresponding to the three cameras, and the folding device is rotated to transmit the multiple wavelengths of light emitted by the light source through the microscope objective and then through the corresponding reflectors to the corresponding cameras to achieve imaging; the expanded angle eyepiece is arranged between the three groups of reflectors and the three corresponding cameras; the expanded angle eyepiece is detachably mounted on the support seat.

[0014] Furthermore, the light source is a replaceable three-spectrum LED lamp panel.

[0015] Furthermore, the microscope objective lens and the support base are detachably connected by magnetic means.

[0016] Furthermore, the three cameras are all provided with a data interface and connected to a computer or a tablet.

[0017] Beneficial effects:

[0018] The present invention integrates optoelectronic technology and artificial intelligence technology to provide a full-spectrum (from ultraviolet to near-infrared) video medical microscope with programmable adjustable receiving wavelength, thereby meeting various application requirements from clinical to scientific research and the spectral requirements required for the diagnosis of different skin disease spectra.

[0019] In addition, the programmable full-spectrum skin video medical microscope provided by the present invention is not only suitable for skin cancer, but also for the detection and evaluation of skin problems including skin inflammation, skin quality, scalp and so on. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 A schematic diagram of the structure of a programmable full-spectrum skin video medical microscope provided in Example 1;

[0021] Figure 2 A schematic diagram of the structure of a programmable full-spectrum skin video medical microscope provided in Example 2;

[0022] Figure 3 This is a top view of the camera main board;

[0023] Figure 4 It is a schematic diagram of the structure of the folding device, the rotating shaft and the reflecting mirror;

[0024] Figure 5 A schematic diagram of the optical path of a programmable full-spectrum skin video medical microscope provided in Example 2;

[0025] Figure 6 It is the spectrum excitation curve diagram of each substance in the skin;

[0026] Among them, 1. Ordinary camera; 2. Multispectral camera capable of receiving NIR spectrum; 3. Multispectral camera capable of receiving VIS spectrum; 4. Spectrometer; 5. Expanded angle eyepiece; 6. Camera main board; 7. Reflection device; 8. Light source; 9. Skin; 10. Reflector; 11. Rotating shaft; 12. Microscope objective. DETAILED DESCRIPTION

[0027] Example 1

[0028] refer to Figure 1 , a programmable full-spectrum skin video medical microscope, comprising:

[0029] Three cameras are installed side by side on the camera main board 6, one of which is a common camera 1, and the other two are multi-spectral cameras;

[0030] A light source 8 capable of emitting light of various wavelengths, the light source 8 being detachably mounted on a support base;

[0031] The optical path transmission unit is located between the light source 8 and the camera and is installed on the support base to transmit the light emitted by the light source 8 to the three cameras.

[0032] In this embodiment, one of the two multispectral cameras is a multispectral camera 3 that can receive VIS spectrum with a wavelength range of 500nm to 700nm; the other is a multispectral camera 2 that can receive NIR spectrum with a wavelength range of 700nm to 900nm.

[0033] In this embodiment, the optical path transmission unit includes a microscope objective 12, three beam splitters 4 and three expanded-angle eyepieces 5. The microscope objective 12 is detachably mounted on a support seat and is arranged corresponding to the light source; the three beam splitters 4 and the three expanded-angle eyepieces 5 are arranged in a one-to-one correspondence and are fixedly mounted on the support seat; the three expanded-angle eyepieces 5 are arranged in a one-to-one correspondence with the three cameras; wherein the three beam splitters 4 are arranged in sequence, and the multiple wavelengths of light emitted by the light source pass through the microscope objective 12 and then pass through the three beam splitters 4 in sequence, and the beam splitter 4 transmits the corresponding object optical information to the corresponding camera through the expanded-angle eyepiece 5 to realize imaging.

[0034] In this embodiment, the microscope objective lens 12 and the support base are detachably connected by magnetic means.

[0035] In this embodiment, the three cameras are all provided with data interfaces and connected to a computer or a tablet.

[0036] In this embodiment, different light sources are used to irradiate the target skin 9 according to different symptoms.

[0037] Specifically, LED lamp beads with multiple wavelengths are installed in front of the microscope objective lens 12, and the microscope objective lens 12 is mounted on the device by magnetic attraction. When switching the light source, the required light source type and its brightness are set by the buttons on the device. By replacing different microscope objective lenses 12, different magnifications can be achieved.

[0038] When the light source is irradiated onto the target skin, general scattering, elastic scattering and fluorescence excitation are simultaneously generated.

[0039] In this embodiment, the light generated by general scattering, elastic scattering and fluorescence excitation respectively transmits the corresponding object optical information to the corresponding camera through the corresponding beam splitter 4 to achieve imaging.

[0040] The device is connected to a computer or tablet via a data interface, and the receiving wavelengths of the two multi-spectral cameras are set through the software. Different receiving wavelengths are set for different symptoms.

[0041] The intensity of the response at a specific wavelength is used to determine whether the target skin meets the symptom characteristics.

[0042] Example 2

[0043] refer to Figure 2-5 , a programmable full-spectrum skin video medical microscope, comprising:

[0044] Three cameras are installed side by side on the camera main board 6, one of which is a common camera 1, and the other two are multi-spectral cameras;

[0045] A light source 8 capable of emitting light of various wavelengths, the light source 8 being detachably mounted on a support base;

[0046] The optical path transmission unit is located between the light source 8 and the camera and is installed on the support base to transmit the light emitted by the light source 8 to one of the three cameras.

[0047] In this embodiment, one of the two multispectral cameras is a multispectral camera 3 that can receive VIS spectrum with a wavelength range of 500nm to 700nm; the other is a multispectral camera 2 that can receive NIR spectrum with a wavelength range of 700nm to 900nm.

[0048] The optical path transmission unit includes a folding device 7 and a rotating shaft 11. The rotating shaft 11 is connected to the support seat in a damped rotation manner. Three groups of reflectors 10 are arranged in the folding device 7. The three groups of reflectors 10 are respectively arranged corresponding to the three cameras. The folding device 7 is rotated to transmit the multiple wavelengths of light emitted by the light source 8 to the corresponding cameras through the corresponding reflectors 10 to achieve imaging; an expanded angle eyepiece 5 for enlarging the optical path is arranged between the three groups of reflectors 10 and the three corresponding cameras; the expanded angle eyepiece 5 is detachably mounted on the support seat.

[0049] In this embodiment, the optical path transmission unit includes a microscope objective 12, a folding device 7 and an angle-expanding eyepiece 5. The folding device 7 is provided with a rotating shaft 11, and the rotating shaft 11 is connected to the support seat in a damped rotation manner; three groups of reflectors 10 are arranged in the folding device 7, and the three groups of reflectors 10 are respectively arranged corresponding to three cameras, and an angle-expanding eyepiece 5 is arranged between the three groups of reflectors 10 and the three corresponding cameras; the angle-expanding eyepiece 5 is detachably mounted on the support seat; the folding device 7 is rotated to transmit the multiple wavelengths of light emitted by the light source 8 through the microscope objective 12 and then through the corresponding reflectors 10 and the angle-expanding eyepiece 5 to the corresponding camera to realize imaging.

[0050] In this embodiment, the light source 8 is a replaceable three-spectrum LED lamp panel.

[0051] In this embodiment, the angle-expanding eyepiece 5 is detachably connected to the support base by magnetic means.

[0052] In this embodiment, the three cameras are all provided with data interfaces and connected to a computer or a tablet.

[0053] Specifically, after the light source 8 irradiates the target skin 9, general scattering, elastic scattering and fluorescence excitation are simultaneously generated.

[0054] In this embodiment, wavelength light of general scattering, elastic scattering and fluorescence excitation is generated, and the corresponding reflector 10 of the required spectral requirement is adjusted to the corresponding camera through the rotating return device 7, that is, it is transmitted to the corresponding camera through the corresponding reflector 10 and the expanded angle eyepiece 5 to realize imaging.

[0055] The device is connected to a computer or tablet via a data interface, and the receiving wavelengths of the two multi-spectral cameras are set through the software. Different receiving wavelengths are set for different symptoms.

[0056] Whether the target skin 9 meets the symptom characteristics is determined based on the response intensity of the specific wavelength.

[0057] The present invention realizes multi-spectral programming adjustment through computer program software. For example, the wavelength entering the camera can be adjusted in Live mode to reflect the spectrum after the light interacts with skin cells at different wavelengths, thereby performing microscopic analysis.

[0058] The programmable full-spectrum skin video medical microscope provided by the present invention integrates optoelectronic technology and artificial intelligence technology to provide a full-spectrum (from ultraviolet to near-infrared) video medical microscope with programmable adjustable receiving wavelength, thereby meeting various application needs from clinical to scientific research and the spectral requirements required for the diagnosis of different skin disease spectra.

[0059] In addition, the programmable full-spectrum skin video medical microscope provided by the present invention is not only suitable for skin cancer, but also for the detection and evaluation of skin problems including skin inflammation, skin quality, scalp and so on.

[0060] The above description is only a preferred embodiment of the present invention and does not limit the technical scope of the present invention. Therefore, any slight modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention still fall within the scope of the technical solution of the present invention.

Claims

1. A programmable full-spectrum skin video medical microscope, characterized in that: include: Three cameras are installed side by side on the camera mainboard, one of which is a normal camera and the other two are multispectral cameras; A light source capable of emitting light of various wavelengths, wherein the light source is detachably mounted on a support base; An optical path transmission unit is located between the light source and the camera and is installed on the support base to transmit the light emitted by the light source to the three cameras or one of the three cameras.

2. The programmable full-spectrum skin video medical microscope according to claim 1, characterized in that: One of the two multispectral cameras is a multispectral camera capable of receiving VIS spectrum with a wavelength range of 500nm to 700nm; the other is a multispectral camera capable of receiving NIR spectrum with a wavelength range of 700nm to 900nm.

3. The programmable full-spectrum skin video medical microscope according to claim 1 or 2, characterized in that: The optical path transmission unit includes a microscope objective, three beam splitters and three expanded-angle eyepieces, wherein the microscope objective is detachably mounted on the support seat and is arranged corresponding to the light source; the three beam splitters and the three expanded-angle eyepieces are arranged in a one-to-one correspondence and are fixedly mounted on the support seat; the three expanded-angle eyepieces are arranged in a one-to-one correspondence with the three cameras; wherein the three beam splitters are arranged in sequence, and the multiple wavelengths of light emitted by the light source pass through the microscope objective and then pass through the three beam splitters in sequence, and the beam splitter transmits the corresponding object optical information to the corresponding camera through the expanded-angle eyepiece to realize imaging.

4. The programmable full-spectrum skin video medical microscope according to claim 1 or 2, characterized in that: The optical path transmission unit includes a microscope objective, a folding device and an expanded angle eyepiece, the folding device is provided with a rotating shaft, and the rotating shaft is connected to the support seat in a damped rotation manner; three groups of reflectors are arranged in the folding device, and the three groups of reflectors are respectively arranged corresponding to the three cameras, and the folding device is rotated to transmit the multiple wavelengths of light emitted by the light source through the microscope objective and then through the corresponding reflectors to the corresponding cameras to achieve imaging; the expanded angle eyepiece is arranged between the three groups of reflectors and the three corresponding cameras; the expanded angle eyepiece is detachably mounted on the support seat.

5. The programmable full-spectrum skin video medical microscope according to claim 4, characterized in that: The light source is a replaceable three-spectrum LED lamp panel.

6. The programmable full-spectrum skin video medical microscope according to claim 4, characterized in that: The microscope objective lens and the support seat are detachably connected by magnetic means.

7. The programmable full-spectrum skin video medical microscope according to claim 1, characterized in that: The three cameras are all provided with a data interface and connected to a computer or a tablet.

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