Syringe for intraperitoneal injection of polypeptide powder

Abstract

The injector comprises a needle cylinder and an injection piston arranged in the needle cylinder in a matched mode, an isolation assembly is arranged between an injection opening of the needle cylinder and the injection piston, and the isolation assembly comprises an inner piston, an isolation plate and a needle head. The internal piston is slidably connected to the side, close to an injection opening of the needle cylinder, of the needle cylinder in the extending direction of the needle cylinder, the space between the internal piston and the injection piston is filled with solvent, the first end, located in the needle cylinder, of the isolation plate is fixedly connected to the injection opening of the needle cylinder, and the second end of the isolation plate is provided with a blade part which abuts against the internal piston. The isolation plate divides the internal space of the needle cylinder between the internal piston and the injection port into two isolation bins, different polypeptide powder is placed in the two isolation bins, the needle head is fixed on the isolation plate, the needle tip of the needle head is flush with the blade part, and the opening of the needle head is flush with the end part of the isolation plate. The two kinds of polypeptide powder can be simultaneously mixed with a solvent at a bleeding part in time to form the hemostatic gel.

Description

Technical Field

[0001] The invention relates to the field of injection equipment, in particular to a syringe for intraperitoneal injection of polypeptide powder. Background Art

[0002] Intraperitoneal injection of polypeptide powder is a method of administering polypeptide drugs by intraperitoneal injection. Polypeptide powder usually needs to be dissolved in an appropriate solvent first and then injected after forming a solution.

[0003] There are two main options for current abdominal hemostasis solutions. First, the American XStat rapid hemostasis system uses micro cotton wool and chitosan to make a material that can expand 10 times in seconds, quickly closing the wound and stopping bleeding. However, the pusher of this system only compresses and stops bleeding through physical expansion, and cannot directly reach the bleeding site. The other is the hydrogel hemostasis solution that has developed rapidly in recent years. It makes up for the deficiency of the XStat system that cannot directly reach the bleeding site, and achieves hemostasis through physical and physiological mechanisms. However, as a gel state, the stability of hydrogel is not as good as that of polypeptide powder, and the cost in transportation and storage is relatively high.

[0004] Most of the common powder injection formulations currently contain only powder components and need to be mixed with solvents when used. This traditional mode is not a problem when used alone, but in emergency rescue scenarios such as battlefields, two unique polypeptide powders are needed to stop bleeding for the wounded. These two unique polypeptide powders each independently exhibit excellent hemostatic and antibacterial effects. However, when they are accidentally mixed, the interaction between internal molecules will trigger a series of chronic chemical reactions. These reactions may not only weaken each other's original therapeutic effects, but also shorten the overall shelf life of the product. Therefore, the two different polypeptide powders need to be stored separately and mixed with solvents when used to form a hemostatic gel applied to the injured's abdominal affected area. Every second on the battlefield is crucial, and the wounded need to be treated quickly and effectively. This not only increases the complexity of the operation, but may also delay precious first aid time. Summary of the invention

[0005] The purpose of the present invention is to overcome the problems in the prior art and provide a syringe for intraperitoneal injection of polypeptide powders, which can be suitable for battlefield environments and can instantly achieve the mixing of two polypeptide powders with a solvent at the bleeding site to form a hemostatic gel.

[0006] The invention provides a syringe for intraperitoneal injection of polypeptide powder, comprising a syringe and an injection piston matched in the syringe, an isolation component is arranged between the injection port of the syringe and the injection piston, the isolation component isolates the solvent inside the syringe and two different polypeptide powders from each other, the isolation component comprises: an internal piston, an isolation plate and a needle, the internal piston is slidably connected to the side of the syringe close to the injection port of the syringe along the extension direction of the syringe, the solvent is filled between the internal piston and the injection piston, the isolation plate is located inside the syringe, the first end of the isolation plate is fixedly connected to the injection port of the syringe, the second end of the isolation plate is provided with a blade, the blade abuts the internal piston, the isolation plate divides the internal space of the syringe between the internal piston and the injection port into two isolation chambers, different polypeptide powders are placed in the two isolation chambers, the needle head is fixed on the isolation plate, the needle tip of the needle head is flush with the blade, the opening of the needle head is flush with the end of the isolation plate, as the injection piston moves toward the injection port, the blade can cut and pass through the internal piston, the solvent enters through the needle tip of the needle head, flows out from the opening of the needle head and mixes with the polypeptide powder outside the injection port.

[0007] Optionally, the inner piston is made of elastic material.

[0008] Optionally, the internal barrel cavity of the syringe includes a first cavity segment and a second cavity segment connected along its extension direction, the first cavity segment is connected between the injection port and the second cavity segment, the inner diameter of the first cavity segment is smaller than the inner diameter of the second cavity segment, and the first cavity segment and the second cavity segment have a smooth transition.

[0009] Optionally, the inner diameter of the first cavity segment gradually decreases from an end close to the second cavity segment to an end away from the second cavity segment.

[0010] Optionally, the inclination angle of the first cavity segment is forty-five degrees, and the cavity walls of the first cavity segment and the second cavity segment are covered with a super-hydrophobic nano-coating.

[0011] Optionally, the super hydrophobic nano coating uses an antibacterial super hydrophobic nano coating having metal nanoparticles.

[0012] Optionally, a first Luer connector is provided at the injection port of the syringe, and a corresponding second Luer connector is provided on the needle cap, and the first Luer connector and the second Luer connector are detachably connected.

[0013] Optionally, it also includes: multiple extended drug delivery tubes, each extended drug delivery tube has a different length, one end of the extended drug delivery tube is provided with a third Luer connector that cooperates with the first Luer connector, and the third Luer connector is detachably connected to the first Luer connector.

[0014] Optionally, the isolation panel is made of transparent glass.

[0015] Compared with the prior art, the beneficial effects of the present invention are as follows: in the stored state before use of the syringe for intraperitoneal injection of polypeptide powder provided by the present invention, the syringe barrel between the internal piston and the injection piston is filled with a solvent such as saline, and the isolation chambers on both sides of the isolation plate are filled with two different polypeptide powders. At this time, the needle cap is closed at the injection port, and one end of the isolation plate is located at the injection port and the other end is against the internal piston, thereby ensuring the closed state of the isolation chambers on both sides of the isolation plate, avoiding premature leakage and mixing of the two polypeptide powders. When in use, the needle cap is removed, the injection port is inserted into the wound, the injection port is inserted into the wound, and the injection piston is pushed, so that the injection piston, the saline and the internal piston are moved toward the injection port together. During the movement, the blade of the isolation plate gradually cuts and enters the internal piston. With the movement of the internal piston, the isolation plate and the needle tip pass through the internal piston together, so that the needle tip enters the space between the internal piston and the injection piston. Physiological saline enters the needle and flows out of the opening of the needle to the outside of the injection port. At the same time, the internal piston cut and penetrated by the isolation plate and the needle tip still keeps the isolation chamber closed at one end away from the injection port, thereby gradually pushing the two polypeptide powders in the isolation chamber out of the injection port and mixing with the physiological saline pushed out of the needle at the same time, so as to mix at the wound to form a hemostatic gel, thereby achieving the effect of hemostasis, thereby adapting to the wartime environment, and separating dry and wet, reducing the humidity of the powder, and reducing the friction between the powders. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 A first overall structural cross-sectional view of a syringe for intraperitoneal injection of polypeptide powder provided by an embodiment of the present invention;

[0017] Figure 2 A second overall structural sectional view of a syringe for intraperitoneal injection of polypeptide powder provided by an embodiment of the present invention.

[0018] Description of reference numerals:

[0019] 1. Syringe; 11. First cavity section; 12. Second cavity section; 2. Injection piston; 3. Needle cap; 4. Internal piston; 5. Isolation plate; 6. Needle; 7. Push rod. DETAILED DESCRIPTION

[0020] The specific implementation of the present invention is described in detail below, but it should be understood that the protection scope of the present invention is not limited by the specific implementation. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0021] In emergency rescue scenarios such as battlefields, two unique polypeptide powders are needed to stop bleeding of the wounded. These two unique polypeptide powders independently exhibit excellent hemostatic and antibacterial effects. However, when they are accidentally mixed, the interaction between the internal molecules will trigger a series of chronic chemical reactions. These reactions may not only weaken each other's original therapeutic effects, but also shorten the overall shelf life of the product. Therefore, the two different polypeptide powders need to be stored separately and mixed with solvents to form hemostatic gels for application to the wounded's abdominal affected area. Every second on the battlefield is crucial, and the wounded need to be treated quickly and effectively. This not only increases the complexity of the operation, but may also delay precious first aid time.

[0022] To this end, an embodiment of the present invention provides a syringe for intraperitoneal injection of polypeptide powders, which can instantly achieve the mixing of two polypeptide powders with a solvent at the bleeding site to form a hemostatic gel.

[0023] At least one embodiment of the present invention provides a syringe for intraperitoneal injection of polypeptide powder, including a syringe and an injection piston cooperatedly arranged in the syringe, an isolation component is arranged between the injection port of the syringe and the injection piston, the isolation component isolates the solvent inside the syringe and two different polypeptide powders from each other, the isolation component includes: an internal piston, an isolation plate and a needle, the internal piston is slidably connected to the side of the syringe close to the injection port of the syringe along the extension direction of the syringe, the internal piston and the injection piston are filled with solvent, the isolation plate is located inside the syringe, the first end of the isolation plate is fixedly connected to the injection port of the syringe, the second end of the isolation plate is provided with a blade, the blade abuts the internal piston, the isolation plate divides the internal space of the syringe between the internal piston and the injection port into two isolation chambers, different polypeptide powders are placed in the two isolation chambers, the needle head is fixed on the isolation plate, the needle tip of the needle head is flush with the blade, the opening of the needle head is flush with the end of the isolation plate, as the injection piston moves toward the injection port, the blade can cut and pass through the internal piston, the solvent enters through the needle tip of the needle and flows out from the opening of the needle head to mix with the polypeptide powder outside the injection port.

[0024] In the syringe for intraperitoneal injection of polypeptide powder provided by the above-mentioned embodiment of the present invention, two polypeptide powders can be stored separately through the isolation plate, and the solvent is stored in the space between the injection piston and the internal piston. When in use, the internal piston is cut by the blade, so that the solvent flows out of the injection port from the needle opening and mixes with the polypeptide powder outside the injection port at the bleeding site of the patient to form a hemostatic gel.

[0025] The present invention is described below by several specific embodiments. In order to keep the following description of the embodiments of the present invention clear and concise, the detailed description of known functions and known components may be omitted. When any component of the embodiments of the present invention appears in more than one accompanying drawings, the component may be represented by the same reference numeral in each of the accompanying drawings.

[0026] refer to Figure 1 , Figure 1 A first overall structural cross-sectional view of a syringe for intraperitoneal injection of polypeptide powder provided by an embodiment of the present invention, as shown in FIG. Figure 1 As shown, an embodiment of the present invention provides a syringe for intraperitoneal injection of polypeptide powder, comprising a syringe 1 and an injection piston 2 matched with the syringe 1, an isolation component is arranged between the injection port of the syringe 1 and the injection piston 2, the isolation component isolates the solvent inside the syringe 1 and two different polypeptide powders from each other, the isolation component comprises: an internal piston 4, an isolation plate 5 and a needle 6, the syringe 1 and the injection piston 2 matched with the syringe 1, an isolation component is arranged between the injection port of the syringe 1 and the injection piston 2, the internal piston 4 is slidably connected to the side of the syringe 1 close to the injection port of the syringe 1 along the extension direction of the syringe 1, the space between the internal piston 4 and the injection piston 2 is filled with solvent, and the isolation plate 5 is located at the syringe 1. The first end of the internal isolation plate 5 is fixedly connected to the injection port of the syringe 1, and the second end of the isolation plate 5 is provided with a blade, which abuts the internal piston 4. The isolation plate 5 divides the internal space of the syringe 1 between the internal piston 4 and the injection port into two isolation chambers, and different polypeptide powders are placed in the two isolation chambers. The needle 6 is fixed on the isolation plate 5, and the needle tip of the needle 6 is flush with the blade, and the opening of the needle 6 is flush with the end of the isolation plate 5. As the injection piston 2 moves toward the injection port, the blade can cut and pass through the internal piston 4, and the solvent enters through the needle tip of the needle 6 and flows out from the opening of the needle 6 to mix with the polypeptide powder outside the injection port. It should be understood that a needle cap 3 is provided at the injection port, and the injection piston 2 is fixedly connected to the push rod 7.

[0027] Specifically, please refer to Figure 1 In the stored state before use, the syringe 1 between the internal piston 4 and the injection piston 2 is filled with physiological saline, and the isolation chambers on both sides of the isolation plate 5 are filled with two different polypeptide powders. At this time, the needle cap 3 closes the injection port, and one end of the isolation plate 5 is located at the injection port, and the other end is against the internal piston 4, thereby ensuring the closed state of the isolation chambers on both sides of the isolation plate 5 to avoid premature leakage and mixing of the polypeptide powder.

[0028] When in use, remove the needle cap 3, align it with the wound and insert the injection port into the wound, push the push rod 7 to drive the injection piston 2, so that the injection piston 2, the physiological saline and the internal piston 4 move toward the injection port together.

[0029] During this process, the blade of the separation plate 5 gradually cuts into and enters the inner piston 4 .

[0030] As the internal piston 4 moves, the isolation plate 5 and the needle tip of the needle 6 pass through the internal piston 4, so that the needle 6 enters the space between the internal piston 4 and the injection piston 2, allowing the physiological saline to enter the needle 6 and flow out of the opening of the needle to the outside of the injection port. At the same time, the internal piston 4 cut and penetrated by the isolation plate 5 and the needle 6 still keeps the isolation chamber closed at one end away from the injection port, so that the two powders in the isolation chamber are gradually pushed out of the injection port and mixed with the physiological saline pushed out from the needle 6 at the same time, so as to mix at the wound to form a hemostatic gel, thereby achieving the technical effect of rapid hemostasis.

[0031] The syringe for intraperitoneal injection of polypeptide powder provided by the present invention is convenient for rapid deployment and can ensure that in an emergency, medical staff can quickly and accurately mix the hemostatic powder and the antibacterial liquid in an optimal ratio to achieve an immediate and efficient treatment effect. At the same time, it is convenient to carry so that it can be easily carried and used in complex environments such as battlefields, truly saving every second and saving lives.

[0032] The syringe provided by the present invention can not only penetrate deep into the abdominal cavity and directly act on the bleeding site to achieve rapid physical and physiological hemostasis, but also maintain the high stability of the polypeptide powder and reduce the cost of transportation and storage. In this way, we can solve the problems in the current hemostasis solution in one fell swoop and provide patients with a safer and more effective hemostasis solution.

[0033] In this embodiment, the isolation plate 5 is made of hard transparent glass, and the shape of the polypeptide powder can be observed with the transparent syringe 1. The blade is set as a knife-like sharp blade flush with the needle tip of the needle 6, which is used to cut the internal piston at the same time as the needle 6 to facilitate the movement of the internal piston 4.

[0034] In another embodiment, the isolation plate 5 may also be made of metal to prevent the isolation plate 5 made of glass from being broken and ineffective due to collision and vibration in a battlefield medical environment, and the isolation plate 5 made of metal material can still cut and pass through the internal piston 4 even if it is deformed to a certain extent. In other embodiments, the isolation plate 5 may also be made of other common chemically inert rigid materials, such as hard resin, hard plastic or modified ceramic material.

[0035] Specifically, the internal piston 4 is made of elastic material. Due to the elasticity of the internal piston 4, when the isolation plate 5 gradually enters and passes through the internal piston 4 with its blade, the internal piston 4 and the isolation plate 5 can be kept in close contact due to the squeezing of the inner wall of the syringe 1, thereby preventing the saline from entering the isolation chamber from the cut between the isolation plate 5 and the internal piston 4, thereby preventing the saline and the powder from mixing in advance in the isolation chamber, and also avoiding the leakage phenomenon caused by the cut between the internal piston 4 and the isolation plate 5.

[0036] refer to Figure 2 , Figure 2A second overall structural cross-sectional view of a syringe for intraperitoneal injection of polypeptide powder provided by an embodiment of the present invention, as shown in FIG. Figure 2 As shown, the internal barrel cavity of the syringe 1 includes a first cavity segment 11 and a second cavity segment 12 connected along its extension direction, the first cavity segment 11 is connected between the injection port and the second cavity segment 12, the inner diameter of the first cavity segment 11 is smaller than the inner diameter of the second cavity segment 12, and the first cavity segment 11 and the second cavity segment 12 have a smooth transition, which can increase the smoothness of the polypeptide powder being pushed out of the injection port.

[0037] Specifically, the inner diameter of the first cavity section 11 gradually decreases from one end close to the second cavity section 12 to one end away from the second cavity section 12, so that the polypeptide powder can be smoothly pushed out along the inclined surface.

[0038] Furthermore, the first cavity section 11 has an inclination angle of 45 degrees, and the cavity walls of the first cavity section 11 and the second cavity section 12 are covered with a super-hydrophobic nano-coating, which can increase the smoothness of the polypeptide powder being pushed out of the injection port, further improving the convenience and reliability of operation. The application of super-hydrophobic nano-coating in the pushing of polypeptide powder can be mainly reflected in the following aspects:

[0039] 1. Reduce frictional resistance

[0040] Super-hydrophobic nano-coating has excellent drag reduction performance. During the peptide powder pushing process, the coating can form a smooth and non-adhesive barrier on the inner surface of the pipeline or equipment, significantly reducing the friction resistance between the peptide powder and the pipeline wall. This not only helps to improve the efficiency of peptide powder pushing, but also reduces energy consumption and equipment wear.

[0041] 2. Preventing peptide powder from agglomerating and clogging

[0042] During the transportation process, peptide powders are prone to agglomeration or clogging of pipelines due to moisture, static electricity, etc. Super-hydrophobic nano-coatings can give the surface excellent hydrophobic properties, effectively preventing water or other liquids from penetrating into the peptide powders, thereby reducing the risk of peptide powder agglomeration. At the same time, the smooth surface of the coating can also reduce the adhesion and deposition of peptide powders in the pipeline, further preventing the occurrence of clogging.

[0043] 3. Improve the corrosion resistance and durability of equipment

[0044] Peptide powders may contain some corrosive ingredients that damage the material of the conveying equipment. Super-hydrophobic nano-coating has excellent corrosion resistance and can form a protective layer on the surface of the equipment, effectively isolating the contact between corrosive substances and the equipment material, thereby extending the service life of the equipment.

[0045] 4. Promote the uniformity and stability of peptide powder delivery

[0046] The smooth surface and drag reduction properties of the super-hydrophobic nano-coating help the peptide powder flow evenly in the pipeline, reducing fluctuations and shocks caused by uneven flow rate or pressure fluctuations. This helps to improve the stability and consistency of the peptide powder push, ensuring that the peptide powder can be accurately delivered to the target location according to the predetermined amount and speed.

[0047] Furthermore, the super-hydrophobic nano-coating uses an antibacterial super-hydrophobic nano-coating with metal nano-particles. Since the present embodiment is a medical device and is used in battlefield emergency scenarios, the sterility of the device needs to be considered. Therefore, the super-hydrophobic nano-coating covered on the cavity wall of the first cavity section 11 and the second cavity section 12 considers using an antibacterial super-hydrophobic nano-coating with metal nano-particles, through which the metal nano-particles in the coating react with bacteria, and then induce various types of cell damage, such as lipid peroxidation, DNA damage and protein oxidation, thereby causing cell death, so as to improve the sterility of the device.

[0048] In the present embodiment, the coating spraying raw material is selected from NanoxTM S2613P nanometer Al2O3-13%TiO2 powder, the particle size is 50~500nm, and the composition (by mass fraction) is: w(Al2O3):w(TiO2)=87∶13, CeO26%~8%, ZrO28%~10%. Nanometer Al2O3-13%TiO2 powder is made by mixing Al2O3, TiO2, ZrO2, CeO2 particles uniformly, and is prepared after spray granulation, plasma flame flow treatment, heat treatment and other process treatments. Other metal nanoparticle antibacterial super-hydrophobic nano coatings of similar composition can also be used.

[0049] Furthermore, a first Luer connector is provided at the injection port of the syringe 1, and a corresponding second Luer connector is provided on the needle cap 3. The first Luer connector and the second Luer connector are detachably connected, and the needle cap 3 and the needle 6 are butt-jointed together through the first Luer connector, with a threaded structure and precise combination to prevent transportation contamination and leakage.

[0050] Furthermore, it includes multiple extended drug delivery tubes, each of which has a different length. One end of the extended drug delivery tube is provided with a third Luer connector that cooperates with the first Luer connector. The third Luer connector and the first Luer connector are detachably connected to facilitate assembly. In this way, the extended drug delivery tube can be selected according to the location of the abdominal cavity injury to ensure that the medicine is directly delivered to the injury, and the extended injection tube is not easy to fall off during injection.

[0051] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations can be made to the embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A syringe for intraperitoneal injection of polypeptide powder, comprising a syringe (1) and an injection piston (2) cooperatively arranged in the syringe (1), characterized in that: An isolation component is provided between the injection port of the syringe (1) and the injection piston (2), and the isolation component isolates the solvent inside the syringe (1) and the two different polypeptide powders from each other. The isolation component comprises: An internal piston (4) is slidably connected to a side of the syringe (1) close to the injection port of the syringe (1) along the extension direction of the syringe (1), and a solvent is filled between the internal piston (4) and the injection piston (2); An isolation plate (5) is located inside the syringe (1). The first end of the isolation plate (5) is fixedly connected to the injection port of the syringe (1). The second end of the isolation plate (5) is provided with a blade, which abuts against the internal piston (4). The isolation plate (5) divides the internal space of the syringe (1) between the internal piston (4) and the injection port into two isolation chambers, and different polypeptide powders are placed in the two isolation chambers. A needle (6) is fixed on the isolation plate (5), the needle tip of the needle (6) is flush with the blade, and the opening of the needle (6) is flush with the end of the isolation plate (5); As the injection piston (2) moves toward the injection port, the blade can cut and pass through the internal piston (4), and the solvent enters through the needle tip of the needle (6) and flows out from the opening of the needle (6) to mix with the polypeptide powder outside the injection port.

2. A syringe for intraperitoneal injection of polypeptide powder according to claim 1, characterized in that: The inner piston (4) is made of elastic material.

3. A syringe for intraperitoneal injection of polypeptide powder according to claim 1, characterized in that: The inner barrel cavity of the syringe (1) comprises a first cavity section (11) and a second cavity section (12) connected along the extension direction thereof, the first cavity section (11) is connected between the injection port and the second cavity section (12), the inner diameter of the first cavity section (11) is smaller than the inner diameter of the second cavity section (12), and the first cavity section (11) and the second cavity section (12) have a smooth transition.

4. A syringe for intraperitoneal injection of polypeptide powder according to claim 3, characterized in that: The inner diameter of the first cavity section (11) gradually decreases from an end close to the second cavity section (12) to an end away from the second cavity section (12).

5. A syringe for intraperitoneal injection of polypeptide powder according to claim 4, characterized in that: The inclination angle of the first cavity section (11) is forty-five degrees, and the cavity walls of the first cavity section (11) and the second cavity section (12) are covered with a super-hydrophobic nano coating.

6. A syringe for intraperitoneal injection of polypeptide powder according to claim 5, characterized in that: The super hydrophobic nano coating is an antibacterial super hydrophobic nano coating with metal nanoparticles.

7. A syringe for intraperitoneal injection of polypeptide powder according to claim 1, characterized in that: The injection port of the syringe (1) is provided with a first Luer connector, and the needle cap (3) is provided with a corresponding second Luer connector, and the first Luer connector and the second Luer connector are detachably connected.

8. A syringe for intraperitoneal injection of polypeptide powder according to claim 7, characterized in that: Also includes: A plurality of extended drug delivery tubes are provided, each of which has a different length. One end of the extended drug delivery tube is provided with a third Luer connector that matches the first Luer connector, and the third Luer connector is detachably connected to the first Luer connector.

9. A syringe for intraperitoneal injection of polypeptide powder according to claim 1, characterized in that: It is characterized in that The isolation plate (5) is made of transparent glass.

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