Traditional Chinese medicine composition and traditional Chinese medicine ointment for treating acne and preparation method of traditional Chinese medicine composition and traditional Chinese medicine ointment

Abstract

The invention discloses a traditional Chinese medicine composition for treating acne. The traditional Chinese medicine composition is prepared from radix ampelopsis, rhizoma bletillae, radix paeoniae alba, radix angelicae, cortex dictamni, cortex mori radicis, herba selaginellae, herba schizonepetae and rhizoma curcumae in equal parts by mass. The invention further discloses a traditional Chinese medicine ointment and a preparation method thereof. Compared with the prior art, the invention can solve the problem of increased drug resistance caused by antibiotic-based antibacterial ointment, and the problem of poor drug release property caused by using yellow vaseline as a grease matrix.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for treating acne, a traditional Chinese medicine ointment and a preparation method thereof. Background Art

[0002] Acne is a chronic inflammatory disease that affects hair follicles and sebaceous glands. Its onset is mainly related to androgen levels and increased sebaceous gland secretion. In addition, microbial colonization, interactions between microorganisms, and inflammation are all related to the onset of acne. In acne lesions, the resident bacteria include Propionibacterium acnes and Staphylococcus epidermidis, and the temporary resident bacteria include Staphylococcus aureus. Antibiotics are widely used in the treatment of acne to inhibit or eradicate acne-related pathogens. For moderate to severe acne, the use of antibiotics, hormones, and retinoic acid drugs is a more systematic approach. However, the problem of antibiotic resistance is becoming increasingly prominent, and long-term use of hormone drugs can easily lead to hormonal acne or folliculitis, complicating the condition. Acne is prone to occur on the face, and scars and pigmentation may remain in the later stages, affecting the physical and mental health of patients.

[0003] Currently, the drugs for treating acne on the market are mainly ointments based on antibiotics, hormones, and retinoic acid drugs. Long-term use leads to increased bacterial resistance to the drugs and causes problems such as hormonal acne and folliculitis.

[0004] Traditional ointments use yellow vaseline as a matrix. Yellow vaseline is an oily matrix. Due to its greasy and poor hydrophobicity, it has the disadvantages of poor drug release performance, is not easy to wash off with water, and is not suitable for skin with exudate.

[0005] In view of this, a Chinese medicine composition, cream, ointment and preparation method for treating acne are proposed. Summary of the invention

[0006] The purpose of the present invention is to provide a Chinese medicine composition for treating acne, a Chinese medicine ointment and a preparation method thereof, so as to solve the problems of increased drug resistance caused by antibacterial ointments mainly based on antibiotics and poor drug release caused by yellow vaseline as an oily matrix.

[0007] The above technical objectives of the present invention are achieved through the following technical solutions:

[0008] A traditional Chinese medicine composition for treating acne comprises equal parts by weight of Radix Bletillae Sinensis, Rhizoma Bletillae, Radix Paeoniae Alba, Radix Angelicae Dahuricae, Cortex Dictamni, Cortex Mori, Folium Selaginellae, Folium Nepetae and Rhizoma Curcumae.

[0009] In a preferred embodiment, the herb Radix Ampelopsis, Rhizoma Bletillae, Radix Paeoniae Alba, Radix Angelicae Dahuricae, Cortex Dictamni, Cortex Mori, Folium Selaginellae, Folium Nepetae and Rhizoma Curcumae are in the form of extracts.

[0010] In a preferred embodiment, it is composed of equal parts by weight of Radix Ampelopsis, Rhizoma Bletillae, Radix Paeoniae Alba, Radix Angelicae Dahuricae, Cortex Dictamni, Cortex Mori, Folium Selaginellae, Folium Nepetae and Rhizoma Curcumae.

[0011] A traditional Chinese medicine ointment comprises active ingredients and an ointment base, wherein the active ingredients comprise equal parts by weight of Radix Bletillae Sinensis, Rhizoma Bletillae, Radix Paeoniae Alba, Radix Angelicae Dahuricae, Cortex Dictamni, Cortex Mori, Folium Selaginellae, Herba Schizonepetae and Rhizoma Curcumae, the ointment base is PEG, the PEG comprises solid PEG and liquid PEG, the mass ratio of the liquid PEG to the solid PEG is 1-2, the traditional Chinese medicine ointment is used in conjunction with a patch, the patch is provided with a limiting through hole, and the patch comprises a base layer and an adhesive layer.

[0012] A method for preparing an ointment comprises the steps of:

[0013] Ingredients: Take active ingredients and ointment base, wherein the active ingredients are 4-6 parts by weight, the dye base is 5-7 parts by weight, the active ingredients include equal parts of Radix Ampelopsis, Rhizoma Bletillae, Radix Paeoniae Alba, Radix Angelicae Dahuricae, Cortex Dictamni, Cortex Mori, Folium Selaginellae, Folium Nepetae and Rhizoma Curcumae, and the ointment base is PEG;

[0014] Preparation of extract: Grind white peony root, white peony root, angelica root, white moss bark, white mulberry bark, Selaginella leaf, Nepeta tenuifolia and Curcuma zedoaria into powder, and then respectively perform the following processes: soak with 65% ethanol for 1-2 hours, then perform heating reflux extraction, perform heating reflux extraction twice, use 12 times the amount of 65% ethanol for the first time, extract for 2-3 hours, filter to obtain a filtrate, use 10 times the amount of 65% ethanol for the second time, extract for 1-2 hours, filter to obtain a filtrate, combine the two filtrates, recover ethanol, and concentrate the filtrate to obtain white peony root extract, white peony root extract, angelica root extract, white moss bark extract, white mulberry bark extract, Selaginella leaf extract, Nepeta tenuifolia extract and Curcuma zedoaria extract;

[0015] Mixing: Heat PEG to 85-88°C, then add Bletilla striata extract, Bletilla striata extract, White Peony Root extract, Angelica dahurica extract, Dictamni peel extract, Morus alba extract, Selaginella leaf extract, Nepeta tenuifolia extract and Curcuma zedoaria extract, homogenize and emulsify, stir until coagulated, and obtain a traditional Chinese medicine ointment.

[0016] In a preferred embodiment, the PEG includes solid PEG and liquid PEG, and the mass ratio of the liquid PEG to the solid PEG is 1-2. In the mixing step, the solid PEG and the liquid PEG are first mixed and heated, and then the white ampel extract, the white striata extract, the white peony extract, the angelica extract, the white moss extract, the white mulberry bark extract, the Selaginella leaf extract, the Nepeta extract and the Curcuma extract are added.

[0017] In a preferred embodiment, the specific process of the mixing step includes: heating PEG to 85°C-88°C, then adding Bletilla striata extract, Bletilla striata extract, White Peony Root extract, Angelica dahurica extract, Dictamni extract, Morus alba extract, Selaginella leaf extract, Nepeta tenuifolia extract and Curcuma zedoaria extract, homogenizing and emulsifying, stirring until coagulated, and adding sodium hyaluronate to obtain a traditional Chinese medicine ointment.

[0018] In a preferred embodiment, the sodium hyaluronate accounts for 10%-20% by mass of the traditional Chinese medicine ointment.

[0019] In a preferred embodiment, the method further comprises the steps of: preparing a patch, wherein the patch is provided with a limiting through hole, and the patch comprises a base layer and an adhesive layer.

[0020] In a preferred embodiment, capsaicin is added to the adhesive layer.

[0021] Compared with the prior art, the Chinese medicine composition of the present invention comprises equal parts of Radix Ampelopsis, Rhizoma Bletillae, Radix Paeoniae Alba, Radix Angelicae Dahuricae, Cortex Dictamni, Cortex Mori, Folium Selaginellae, Herba Schizonepetae and Rhizoma Curcumae, and these Chinese medicine components act synergistically to exert powerful effects. In the extraction method, the extract is more conducive to the exertion of the effective ingredients in the form of extract. Through a specific preparation process, each medicinal material is ground into powder and then soaked in 65% ethanol and heated under reflux for extraction, the extraction number, solvent amount and time are strictly controlled to ensure the full extraction of the effective ingredients, and ethanol is recovered and the filtrate is concentrated to obtain a pure extract, which lays a solid foundation for the subsequent preparation of an ointment.

[0022] In terms of ointment matrix, the use of PEG as the matrix has significant advantages. PEG is specifically polyethylene glycol. PEG is an amphiphilic matrix with good affinity for both water and oil. When mixed with wound exudate or secretions, it can effectively promote the contact between the drug and the skin. Compared with traditional lipophilic oily matrices, its drug release and skin penetration performance are stronger, allowing the active ingredients in the drug to reach the site of action more quickly and efficiently.

[0023] From the perspective of pharmacological effects, the Chinese medicine ingredients in this case have antibacterial and anti-inflammatory effects. The combination of multiple medicinal materials results in a high content of effective antibacterial ingredients, a low dosage and few toxic side effects. In the field of acne treatment, this effectively overcomes the problems of increased bacterial resistance and hormonal acne caused by long-term use of commercially available antibacterial ointments based on antibiotics and hormones. Achieving the therapeutic purpose through natural Chinese medicine ingredients can not only effectively inhibit the growth and reproduction of pathogens such as Propionibacterium acnes, but also reduce inflammatory reactions and relieve symptoms such as redness, swelling and pain in acne patients.

[0024] The Chinese medicine ointment is used in conjunction with the patch. The patch is set with a limit hole, which can accurately place the affected area within the range of the hole when used. This design solves the problem that the drug is easy to diffuse after being applied on the skin surface and the action position is not accurate. When the patch is attached to the skin, it is like establishing an exclusive "action channel" for the drug, so that the effective liquid in the ointment can accurately act on the affected area, greatly improving the utilization efficiency of the drug, avoiding the waste of drugs in healthy skin areas, and reducing the potential side effects that may be caused by drug diffusion.

[0025] When the patch is attached to the affected area, capsaicin will produce a heating effect, which can effectively promote blood circulation in the affected area through heating. When the blood flow speed is accelerated, on the one hand, it opens up a smoother "road" for the delivery of drugs, so that the active ingredients in the ointment can reach the lesion site faster; on the other hand, accelerated blood circulation helps to enhance the metabolic capacity of cells and create a more favorable microenvironment for the absorption and action of drugs. Under the synergistic effect of thermal effect and blood flow, the drug can penetrate into the deep tissue of the skin more quickly and exert its antibacterial, anti-inflammatory and other therapeutic effects. On the whole, the patch not only limits the action position of the drug at the physical level, but also helps the drug to play a better role from the perspective of physiological regulation. It plays an indispensable auxiliary and enhancing effect in the process of treating skin diseases such as acne with traditional Chinese medicine ointments.

[0026] The Chinese medicine ointment developed by the present invention improves the matrix components, enhances the clinical efficacy, and meets the patient's demand for safe and effective acne treatment drugs. Both mild acne patients and moderate to severe acne patients can benefit from it. For mild acne, it can effectively eliminate acne and papules to prevent further development of the disease; for moderate to severe acne, it can reduce inflammation, promote skin lesion healing, and reduce the risk of scar formation. Moreover, the Chinese medicine preparation is mild in nature, not easy to cause adverse reactions such as allergies, and is suitable for people with different skin types, providing a new and reliable option for acne treatment. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 The present invention relates to a flow chart of a method for preparing an ointment.

[0028] Figure 2 It is a schematic diagram of the structure of the patch.

[0029] In the picture

[0030] Base layer 1; Adhesive layer 2. DETAILED DESCRIPTION

[0031] The present invention is further described in detail below in conjunction with the accompanying drawings.

[0032] This specific embodiment is merely an explanation of the present invention and is not a limitation of the present invention. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed. However, as long as they are within the scope of the claims of the present invention, they are protected by the patent law.

[0033] Embodiment 1:

[0034] A traditional Chinese medicine composition for treating acne comprises equal parts by weight of Radix Bletillae Sinensis, Rhizoma Bletillae, Radix Paeoniae Alba, Radix Angelicae Dahuricae, Cortex Dictamni, Cortex Mori, Folium Selaginellae, Folium Nepetae and Rhizoma Curcumae.

[0035] Furthermore, the white ampelopsis, white striata, white peony root, angelica dahurica, white moss bark, white mulberry bark, selaginella leaf, schizonepeta and zedoaria are in the form of extracts.

[0036] Furthermore, it is composed of equal parts by weight of Bletilla striata, Bletilla striata, White Peony Root, Angelica dahurica, Dictamni bark, Morus alba bark, Selaginella leaf, Nepeta tenuifolia and Curcuma zedoaria.

[0037] Among the above ingredients, their effects are as follows:

[0038] Bletilla striata. Bletilla striata has the effects of clearing away heat and detoxifying, eliminating carbuncle and dispersing nodules, and healing sores and promoting tissue regeneration. In the treatment of acne, its heat-clearing and detoxifying effects help to remove heat and toxins in the body, reduce the inflammatory response caused by the accumulation of heat and toxins, and relieve the redness, swelling, heat and pain symptoms of acne in the early stages. Its healing sores and promoting tissue regeneration can promote the repair of the skin in the acne lesions, reduce the risk of scar formation, and restore the skin to smoothness.

[0039] Bletilla striata. Bletilla striata is rich in mucus and other ingredients, which can astringe and stop bleeding, reduce swelling and promote tissue regeneration. In this Chinese medicine combination, it helps to reduce local swelling of acne, and at the same time can promote the regeneration and repair of damaged skin tissue, and work together with Bletilla striata to promote tissue regeneration, accelerate the healing process of acne, and to a certain extent prevent bleeding from skin ulcers, maintaining the skin in a healthy state.

[0040] White peony root. White peony root has the functions of nourishing blood and regulating menstruation, softening the liver and relieving pain, and calming liver yang. From the perspective of acne treatment, the blood-nourishing effect can nourish the skin, improve skin problems caused by insufficient qi and blood, and provide a good internal environment for skin recovery. The liver-softening effect helps regulate the liver function of the human body, because Chinese medicine believes that liver dysfunction is related to the onset of acne. By calming liver yang and softening the liver, the circulation of qi and blood in the body can be regulated, and the aggravation of acne caused by liver depression and fire can be reduced.

[0041] Angelica dahurica. Angelica dahurica can relieve cold, dispel wind and relieve pain, clear the nasal passages, dry dampness and stop leukorrhea, and reduce swelling and discharge pus. Its ability to reduce swelling and discharge pus can effectively treat the abscess symptoms of acne, promote the discharge of pus from the body, and reduce inflammation and swelling. At the same time, its pungent and dispersing nature can dredge the skin pores, helping other drug ingredients to better penetrate into the skin and exert the overall efficacy.

[0042] White moss peel. White moss peel can clear away heat and dampness, dispel wind and detoxify. For acne, the heat-clearing and damp-drying effect can remove dampness and heat in the body, which is one of the common factors that lead to the occurrence and development of acne. Its wind-dispelling and detoxifying effect can improve symptoms such as itching, redness and swelling caused by wind evil and heat toxins, relieve patient discomfort, and enhance skin resistance.

[0043] Mulberry bark. Mulberry bark can relieve lung and asthma, promote diuresis and reduce swelling. When treating acne, based on the theory of traditional Chinese medicine that the lung governs the skin and fur, the lung function is regulated by the lung-draining effect, thereby improving the skin condition. The diuretic and swelling-reducing effect helps to discharge excess water and moisture in the body, reduce skin swelling and oiliness caused by stagnant water and moisture, and create a good body water metabolism environment for acne treatment.

[0044] Selaginella leaves. Selaginella leaves have the effects of promoting blood circulation and relieving menstruation. In this prescription, its blood circulation promoting effect can promote local blood circulation, allowing the drug to reach the acne lesions more quickly. It also helps to remove metabolic waste and inflammatory products, accelerate the disappearance of acne, and improve the nutrition supply and metabolism of the skin.

[0045] Schizonepeta. Schizonepeta has the effects of dispelling wind and relieving exterior symptoms, clearing rashes and eliminating sores. In this drug combination, the effect of dispelling wind and relieving exterior symptoms can dispel wind evil and reduce the aggravation of skin problems caused by wind evil invasion. The effect of clearing rashes and eliminating sores helps to promote the clearing of acne rashes, accelerate the disappearance of sores, reduce the inflammatory response of the skin, and restore the skin to normal state.

[0046] Curcuma. Curcuma has the effects of breaking blood and promoting qi, eliminating stagnation and relieving pain. In the treatment of acne, its effect of breaking blood and promoting qi can improve the state of local qi and blood stasis. Acne patients, especially those with a long course of disease or severe conditions, often have poor blood circulation. Curcuma can help dredge qi and blood, promote drug absorption and metabolism, and its effect of eliminating stagnation and relieving pain can also alleviate symptoms such as pain and discomfort caused by poor blood circulation.

[0047] Embodiment 2:

[0048] A Chinese medicine ointment, comprising active ingredients and an ointment base, wherein the active ingredients comprise equal parts of Radix Ampelopsis, Rhizoma Bletillae, Radix Paeoniae Alba, Radix Angelicae Dahuricae, Cortex Dictamni, Cortex Mori, Folium Selaginellae, Folium Nepetae and Rhizoma Curcumae, the ointment base is PEG, the PEG comprises solid PEG and liquid PEG, the mass ratio of the liquid PEG to the solid PEG is 1-2, the Chinese medicine ointment is used in conjunction with a patch, the patch is provided with a limiting through hole, the patch comprises a base layer 1 and an adhesive layer 2, and the structure of the patch is as follows: Figure 2 shown.

[0049] Using PEG as a matrix has significant advantages. PEG is specifically polyethylene glycol. PEG is an amphiphilic matrix with good affinity for both water and oil. When mixed with wound exudate or secretions, it can effectively promote the contact between the drug and the skin. Compared with traditional lipophilic oily matrices, its drug release and skin penetration performance are stronger, allowing the active ingredients in the drug to reach the site of action more quickly and efficiently.

[0050] The Chinese medicine ointment is used in conjunction with the patch. The patch is set with a limit hole, which can accurately place the affected area within the range of the hole when used. This design solves the problem that the drug is easy to diffuse after being applied on the skin surface and the action position is not accurate. When the patch is attached to the skin, it is like establishing an exclusive "action channel" for the drug, so that the effective liquid in the ointment can accurately act on the affected area, greatly improving the utilization efficiency of the drug, avoiding the waste of drugs in healthy skin areas, and reducing the potential side effects that may be caused by drug diffusion.

[0051] When the patch is attached to the affected area, capsaicin will produce a heating effect, which can effectively promote blood circulation in the affected area through heating. When the blood flow speed is accelerated, on the one hand, it opens up a smoother "road" for the delivery of drugs, so that the active ingredients in the ointment can reach the lesion site faster; on the other hand, accelerated blood circulation helps to enhance the metabolic capacity of cells and create a more favorable microenvironment for the absorption and action of drugs. Under the synergistic effect of thermal effect and blood flow, the drug can penetrate into the deep tissue of the skin more quickly and exert its antibacterial, anti-inflammatory and other therapeutic effects. On the whole, the patch not only limits the action position of the drug at the physical level, but also helps the drug to play a better role from the perspective of physiological regulation. It plays an indispensable auxiliary and enhancing effect in the process of treating skin diseases such as acne with traditional Chinese medicine ointments.

[0052] Embodiment three:

[0053] like Figure 1 and Figure 2 As shown, a method for preparing an ointment comprises the steps of:

[0054] Ingredients: Take active ingredients and ointment base, wherein the active ingredients are 4-6 parts by weight, the dye base is 5-7 parts by weight, the active ingredients include equal parts of Radix Ampelopsis, Rhizoma Bletillae, Radix Paeoniae Alba, Radix Angelicae Dahuricae, Cortex Dictamni, Cortex Mori, Folium Selaginellae, Folium Nepetae and Rhizoma Curcumae, and the ointment base is PEG;

[0055] Preparation of extract: Grind white peony root, white peony root, angelica root, white moss bark, white mulberry bark, Selaginella leaf, Nepeta tenuifolia and Curcuma zedoaria into powder, and then respectively perform the following processes: soak with 65% ethanol for 1-2 hours, then perform heating reflux extraction, perform heating reflux extraction twice, use 12 times the amount of 65% ethanol for the first time, extract for 2-3 hours, filter to obtain a filtrate, use 10 times the amount of 65% ethanol for the second time, extract for 1-2 hours, filter to obtain a filtrate, combine the two filtrates, recover ethanol, and concentrate the filtrate to obtain white peony root extract, white peony root extract, angelica root extract, white moss bark extract, white mulberry bark extract, Selaginella leaf extract, Nepeta tenuifolia extract and Curcuma zedoaria extract;

[0056] Mixing: Heat PEG to 85-88°C, then add Bletilla striata extract, Bletilla striata extract, White Peony Root extract, Angelica dahurica extract, Dictamni peel extract, Morus alba extract, Selaginella leaf extract, Nepeta tenuifolia extract and Curcuma zedoaria extract, homogenize and emulsify, stir until coagulated, and obtain a traditional Chinese medicine ointment.

[0057] Furthermore, the PEG comprises solid PEG and liquid PEG, the mass ratio of the liquid PEG to the solid PEG is 1-2, and in the mixing step, the solid PEG and the liquid PEG are first mixed and heated, and then white peony root extract, white peony root extract, angelica root extract, white moss bark extract, white mulberry bark extract, Selaginella leaf extract, schizonepeta extract and Curcuma zedoaria extract are added.

[0058] Furthermore, the specific process of the mixing step includes: heating PEG to 85°C-88°C, then adding Bletilla striata extract, Bletilla striata extract, White Peony Root extract, Angelica dahurica extract, Dictamni peel extract, Morus alba extract, Selaginella leaf extract, Nepeta tenuifolia extract and Curcuma zedoaria extract, homogenizing and emulsifying, stirring until coagulated, and adding sodium hyaluronate to obtain a traditional Chinese medicine ointment.

[0059] Furthermore, the sodium hyaluronate accounts for 10%-20% of the mass fraction of the traditional Chinese medicine ointment.

[0060] Furthermore, the method further comprises the steps of: preparing a patch, wherein a limiting through hole is provided in the patch, and the patch comprises a base layer 1 and an adhesive layer 2.

[0061] Furthermore, capsaicin is added into the adhesive layer 2 .

[0062] The Chinese medicine composition of the present embodiment comprises equal mass parts of Radix Ampelopsis, Rhizoma Bletillae, Radix Paeoniae Alba, Radix Angelicae Dahuricae, Cortex Dictamni, Cortex Mori, Folium Selaginellae, Herba Schizonepetae and Rhizoma Curcumae, and these Chinese medicine components act synergistically to exert powerful efficacy. In extraction mode, the presence of extracting liquid form is more conducive to the performance of effective ingredients. By specific preparation technology, each medicinal material is ground into powder and then soaked and heated under reflux with 65% ethanol, and extraction is carried out, and extraction number, solvent amount and time are strictly controlled to ensure the sufficient extraction of effective ingredients, and ethanol is recovered and filtrate is concentrated to obtain pure extracting liquid, which lays a solid foundation for subsequent preparation of ointment.

[0063] In terms of ointment matrix, the use of PEG as the matrix has significant advantages. PEG is specifically polyethylene glycol. PEG is an amphiphilic matrix with good affinity for both water and oil. When mixed with wound exudate or secretions, it can effectively promote the contact between the drug and the skin. Compared with traditional lipophilic oily matrices, its drug release and skin penetration performance are stronger, allowing the active ingredients in the drug to reach the site of action more quickly and efficiently.

[0064] From the perspective of pharmacological effects, the Chinese medicine ingredients in this case have antibacterial and anti-inflammatory effects. The combination of multiple medicinal materials results in a high content of effective antibacterial ingredients, a low dosage and few toxic side effects. In the field of acne treatment, this effectively overcomes the problems of increased bacterial resistance and hormonal acne caused by long-term use of commercially available antibacterial ointments based on antibiotics and hormones. Achieving the therapeutic purpose through natural Chinese medicine ingredients can not only effectively inhibit the growth and reproduction of pathogens such as Propionibacterium acnes, but also reduce inflammatory reactions and relieve symptoms such as redness, swelling and pain in acne patients.

[0065] The Chinese medicine ointment is used in conjunction with the patch. The patch is set with a limit hole, which can accurately place the affected area within the range of the hole when used. This design solves the problem that the drug is easy to diffuse after being applied on the skin surface and the action position is not accurate. When the patch is attached to the skin, it is like establishing an exclusive "action channel" for the drug, so that the effective liquid in the ointment can accurately act on the affected area, greatly improving the utilization efficiency of the drug, avoiding the waste of drugs in healthy skin areas, and reducing the potential side effects that may be caused by drug diffusion.

[0066] When the patch is attached to the affected area, capsaicin will produce a heating effect, which can effectively promote blood circulation in the affected area through heating. When the blood flow speed is accelerated, on the one hand, it opens up a smoother "road" for the delivery of drugs, so that the active ingredients in the ointment can reach the lesion site faster; on the other hand, accelerated blood circulation helps to enhance the metabolic capacity of cells and create a more favorable microenvironment for the absorption and action of drugs. Under the synergistic effect of thermal effect and blood flow, the drug can penetrate into the deep tissue of the skin more quickly and exert its antibacterial, anti-inflammatory and other therapeutic effects. On the whole, the patch not only limits the action position of the drug at the physical level, but also helps the drug to play a better role from the perspective of physiological regulation. It plays an indispensable auxiliary and enhancing effect in the process of treating skin diseases such as acne with traditional Chinese medicine ointments.

[0067] The Chinese medicine ointment developed by the present invention improves the matrix components, enhances the clinical efficacy, and meets the patient's demand for safe and effective acne treatment drugs. Both mild acne patients and moderate to severe acne patients can benefit from it. For mild acne, it can effectively eliminate acne and papules to prevent further development of the disease; for moderate to severe acne, it can reduce inflammation, promote skin lesion healing, and reduce the risk of scar formation. Moreover, the Chinese medicine preparation is mild in nature, not easy to cause adverse reactions such as allergies, and is suitable for people with different skin types, providing a new and reliable option for acne treatment.

[0068] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that the process, method, article or terminal device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or terminal device. In the absence of further restrictions, the elements defined by the sentence "include..." or "comprise..." do not exclude the existence of other elements in the process, method, article or terminal device including the elements. In addition, in this article, "greater than", "less than", "exceed" and the like are understood to exclude the number itself; "above", "below", "within" and the like are understood to include the number itself.

[0069] The above description of the embodiments is to facilitate the understanding and use of the present invention by those skilled in the art. It is obvious that those skilled in the art can easily make various modifications to the embodiments and apply the general principles described herein to other embodiments without creative work. Therefore, the present invention is not limited to the above embodiments. Improvements and modifications made by those skilled in the art based on the disclosure of the present invention without departing from the scope of the present invention should be within the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating acne, characterized in that: The invention comprises equal parts of Bletilla striata, Bletilla striata, White Peony Root, Angelica dahurica, Dictamni bark, Morus alba bark, Selaginella leaf, Nepeta tenuifolia and Curcuma zedoaria.

2. A Chinese medicine composition for treating acne according to claim 1, characterized in that: The white peony root, white peony root, angelica dahurica, white moss bark, white mulberry bark, selaginella leaf, schizonepeta and zedoaria are in the form of extracts.

3. A Chinese medicine composition for treating acne according to claim 1, characterized in that: The invention is composed of equal parts of white peony root, white bletilla striata, white peony root, angelica dahurica, white moss bark, mulberry bark, Selaginella leaf, Nepeta tenuifolia and Curcuma zedoaria.

4. A Chinese medicine ointment, characterized in that: The composition comprises active ingredients and an ointment matrix, wherein the active ingredients comprise equal parts of Radix Bletillae Sinensis, Rhizoma Bletillae, Radix Paeoniae Alba, Radix Angelicae Dahuricae, Cortex Dictamni, Cortex Mori, Folium Selaginellae, Folium Nepetae and Rhizoma Curcumae, the ointment matrix is ​​PEG, the PEG comprises solid PEG and liquid PEG, the mass ratio of the liquid PEG to the solid PEG is 1-2, the traditional Chinese medicine ointment is used in combination with a patch, the patch is provided with a limiting through hole, and the patch comprises a base layer and an adhesive layer.

5. A method for preparing an ointment, characterized in that: Includes steps: Ingredients: Take active ingredients and ointment base, wherein the active ingredients are 4-6 parts by weight, the dye base is 5-7 parts by weight, the active ingredients include equal parts of Radix Ampelopsis, Rhizoma Bletillae, Radix Paeoniae Alba, Radix Angelicae Dahuricae, Cortex Dictamni, Cortex Mori, Folium Selaginellae, Folium Nepetae and Rhizoma Curcumae, and the ointment base is PEG; Preparation of extract: Grind white peony root, white peony root, angelica root, white moss bark, white mulberry bark, Selaginella leaf, Nepeta tenuifolia and Curcuma zedoaria into powder, and then respectively perform the following processes: soak with 65% ethanol for 1-2 hours, then perform heating reflux extraction, perform heating reflux extraction twice, use 12 times the amount of 65% ethanol for the first time, extract for 2-3 hours, filter to obtain a filtrate, use 10 times the amount of 65% ethanol for the second time, extract for 1-2 hours, filter to obtain a filtrate, combine the two filtrates, recover ethanol, and concentrate the filtrate to obtain white peony root extract, white peony root extract, angelica root extract, white moss bark extract, white mulberry bark extract, Selaginella leaf extract, Nepeta tenuifolia extract and Curcuma zedoaria extract; Mixing: Heat PEG to 85-88°C, then add Bletilla striata extract, Bletilla striata extract, White Peony Root extract, Angelica dahurica extract, Dictamni peel extract, Morus alba extract, Selaginella leaf extract, Nepeta tenuifolia extract and Curcuma zedoaria extract, homogenize and emulsify, stir until coagulated, and obtain a traditional Chinese medicine ointment.

6. A method for preparing an ointment according to claim 5, characterized in that: The PEG comprises solid PEG and liquid PEG, wherein the mass ratio of the liquid PEG to the solid PEG is 1-2. In the mixing step, the solid PEG and the liquid PEG are first mixed and heated, and then white peony root extract, white peony root extract, angelica root extract, white moss bark extract, white mulberry bark extract, Selaginella leaf extract, schizonepeta extract and zedoaria extract are added.

7. The method for preparing an ointment according to claim 5, characterized in that: The specific process of the mixing step includes: heating PEG to 85°C-88°C, then adding white peony root extract, white peony root extract, angelica root extract, white moss bark extract, mulberry bark extract, Selaginella leaf extract, schizonepeta extract and zedoaria extract, homogenizing and emulsifying, stirring until coagulation, and adding sodium hyaluronate to obtain a traditional Chinese medicine ointment.

8. The method for preparing an ointment according to claim 5, characterized in that: The sodium hyaluronate accounts for 10%-20% of the mass fraction of the traditional Chinese medicine ointment.

9. The method for preparing an ointment according to claim 6, characterized in that: The method also includes the steps of: preparing a patch, wherein the patch is provided with a limiting through hole, and the patch includes a base layer and an adhesive layer.

10. The method for preparing an ointment according to claim 9, characterized in that: Capsaicin is added into the adhesive layer.

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