Flexible electrocardio acquisition integrated array and preparation method

Abstract

The invention discloses a flexible electrocardio acquisition integrated array and a preparation method, and the flexible electrocardio acquisition integrated array comprises a flexible substrate which is formed based on an organic polymer solution; one part of the conductive layer uniformly covers the surface of the flexible substrate, and the other part of the conductive layer is embedded into the flexible substrate; the conductive layer is formed by mixing a two-dimensional layered conductive material and a one-dimensional linear conductive material; the conductive layer comprises a plurality of lead channels for lead electrocardiogram acquisition; wherein each lead channel comprises a round probe, a connecting line and a bonding pad, and the round probe is connected with the bonding pad through the connecting line. The flexible electrocardio acquisition integrated array provided by the invention has flexibility, high conductivity, stretchability and high stability at the same time, and has relatively low contact impedance, so that the quality of acquired electrocardio signals is improved while the wearing comfort of the electrocardio electrodes is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of electrocardiogram signals, and in particular to a flexible electrocardiogram acquisition integrated array and a preparation method thereof. Background Art

[0002] As the number of people suffering from cardiovascular diseases increases year by year, ECG monitoring can effectively prevent the occurrence of cardiovascular diseases, so more and more people pay attention to ECG testing. At present, a large number of researchers at home and abroad have developed a series of ECG acquisition systems to achieve real-time dynamic monitoring of human ECG signals. As an important part of it, the sensor not only affects the quality of the collected ECG signals, but also affects the comfort of wearing it because it is in direct contact with human skin.

[0003] There are many studies on flexible electrodes at home and abroad, which can be well applied to the field of wearable devices for collecting human ECG signals. First of all, most of the production processes of flexible electrodes are photolithography, screen printing, inkjet printing, laser printing, etc., but there are shortcomings such as complex operation and high cost; secondly, due to the limitation of the selected substrate material, it does not have good flexibility and stretchability, which affects the comfort of wearing electrodes when collecting ECG and the quality of ECG signals collected in motion; finally, in view of the shortcomings of existing ECG collection equipment, most ECG collection equipment can only monitor single-lead ECG signals and cannot fully reflect the health of the heart. If the standard human twelve-lead ECG signal is collected, it will cause problems such as complex operation and many lead wires, which will cause discomfort to the human body.

[0004] Therefore, the prior art needs to be improved. Summary of the invention

[0005] The technical problem to be solved by the present invention is that, in view of the defects of the prior art, the present invention provides a flexible ECG acquisition integrated array and a preparation method to solve the problems of high process cost and low monitoring accuracy of the existing flexible ECG acquisition equipment.

[0006] The technical solution adopted by the present invention to solve the technical problem is as follows: In a first aspect, the present invention provides a flexible ECG acquisition integrated array, comprising: A flexible substrate, wherein the flexible substrate is a substrate formed based on an organic polymer solution; A conductive layer, a portion of which is evenly covered on the surface of the flexible substrate, and another portion of which is embedded in the flexible substrate; the conductive layer is a conductive layer formed by mixing a two-dimensional layered conductive material and a one-dimensional linear conductive material; The conductive layer includes: a plurality of lead channels for collecting lead electrocardiograms; wherein each lead channel includes a round probe, a connecting wire and a pad, and the round probe is connected to the pad via the connecting wire.

[0007] In a second aspect, the present invention provides a method for preparing a flexible ECG acquisition integrated array, which is used to prepare the flexible ECG acquisition integrated array as described in the first aspect, comprising: Providing a substrate, and etching a preset integrated array pattern on the substrate to obtain an etched substrate; Ultrasonic treatment is performed on the two-dimensional conductive nanomaterial solution to obtain a uniform two-dimensional layered solution; The two-dimensional layered solution is mixed with a one-dimensional conductive material, and then subjected to ultrasonic treatment to obtain a uniform conductive mixed solution; Drop-coating the conductive mixed solution on the etched substrate, and performing annealing and drying to form a conductive layer to obtain a pre-treated substrate; The organic polymer solution is spin-coated on the pre-processed substrate, and then dried and annealed to prepare a flexible electrocardiogram collection integrated array on the pre-processed substrate.

[0008] In one implementation, the preset integrated array pattern includes a first pattern and a second pattern; The first pattern is a pattern integrated by 6 lead channels, wherein each lead channel includes a round probe, a connecting wire and a pad, and the round probe is connected to the pad through the connecting wire; The second pattern is a pattern of four separate lead channels.

[0009] In one implementation, the solvent of the two-dimensional conductive nanomaterial solution is deionized water or alcohol; The two-dimensional conductive nanomaterial solution is subjected to ultrasonic treatment to obtain a uniform two-dimensional layered solution, comprising: After adding a solvent of a preset concentration into the two-dimensional conductive nanomaterial, the two-dimensional conductive nanomaterial solution is subjected to a first ultrasonic treatment to make the solute distribution in the two-dimensional conductive nanomaterial solution more uniform, thereby obtaining the uniform two-dimensional layered solution; wherein the power of the first ultrasonic treatment is 60-80W, and the ultrasonic duration is 8-25min.

[0010] In one implementation, the two-dimensional conductive nanomaterial is one or more of graphene, MXene material, niobium arsenide nanoribbon, molybdenum disulfide and black phosphorus.

[0011] In one implementation, the two-dimensional layered solution is mixed with a one-dimensional conductive material, and then subjected to ultrasonic treatment to obtain a uniform conductive mixed solution, comprising: adding the one-dimensional conductive material into the two-dimensional layered solution, and performing a second ultrasonic treatment to obtain the uniform conductive mixed solution; The power of the second ultrasonic treatment is 80-100 W, and the ultrasonic duration is 15-40 min; the one-dimensional conductive material is one or more of carbon nanotubes, metal nanowires, zinc oxide nanowires and silver nanowires.

[0012] In one implementation, the annealing drying temperature of the pre-treated substrate is 45-50° C. and the time is 2-3 hours.

[0013] In one implementation, the organic polymer solution is one or more of polyvinylidene fluoride, polydimethylsiloxane, hydrogenated styrene-butadiene block copolymer and polyurethane.

[0014] In one implementation, the organic polymer solution is spin-coated on the pre-treated substrate at a spin-coating speed of 800-1000 rpm.

[0015] In one implementation, the temperature of annealing and drying the pre-treated substrate after spin coating the organic polymer solution is 60-95° C. and the time is 50-90 min.

[0016] The present invention adopts the above technical solution to achieve the following effects: The present invention proposes a flexible ECG acquisition integrated array, which can be used for the acquisition of multi-lead ECG signals of human body. When acquiring multi-lead ECG signals, since the flexible ECG acquisition integrated array has a certain integrated design, it can avoid the problems of complicated operation and uncomfortable wearing caused by multiple lead wires. The flexible ECG acquisition integrated array provided by the present invention has flexibility, high conductivity, stretchability and high stability, and has low contact impedance, which improves the comfort of wearing ECG electrodes and improves the quality of the collected ECG signals. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the structures shown in these drawings without paying creative work.

[0018] Figure 1 It is a structural schematic diagram of the flexible ECG acquisition integrated array in the present invention.

[0019] Figure 2 It is a flow chart of the method for preparing the flexible ECG acquisition integrated array in the present invention.

[0020] Figure 3 It is a physical simulation schematic diagram of the flexible ECG acquisition integrated array in the present invention.

[0021] Figure 4 It is a simulation schematic diagram of the flexible ECG acquisition integrated array in the present invention being applied to twelve-lead ECG acquisition.

[0022] Figure 5 It is a 12-lead ECG signal graph collected by the flexible ECG collection integrated array of the present invention.

[0023] The purpose, features and advantages of the present invention will be further described with reference to the accompanying drawings in conjunction with the embodiments. DETAILED DESCRIPTION

[0024] In order to make the purpose, technical solution and advantages of the present invention clearer and more specific, the present invention is further described in detail below with reference to the accompanying drawings and examples. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0025] Exemplary Devices There are many studies on flexible electrodes at home and abroad, which can be well applied to the field of wearable devices for collecting human ECG signals. First of all, most of the production processes of flexible electrodes are photolithography, screen printing, inkjet printing, laser printing, etc., but there are shortcomings such as complex operation and high cost; secondly, due to the limitation of the selected substrate material, it does not have good flexibility and stretchability, which affects the comfort of wearing electrodes when collecting ECG and the quality of ECG signals collected in motion; finally, in view of the shortcomings of existing ECG collection equipment, most ECG collection equipment can only monitor single-lead ECG signals and cannot fully reflect the health of the heart. If the standard human twelve-lead ECG signal is collected, it will cause problems such as complex operation and many lead wires, which will cause discomfort to the human body.

[0026] In view of the above technical problems, a flexible ECG acquisition integrated array is provided in an embodiment of the present invention. The flexible ECG acquisition integrated array can be used for the acquisition of multi-lead ECG signals of human body. When acquiring multi-lead ECG signals, since the flexible ECG acquisition integrated array has a certain integrated design, it can avoid the problems of complicated operation and uncomfortable wearing caused by multiple lead wires. The flexible ECG acquisition integrated array provided in an embodiment of the present invention has flexibility, high conductivity, stretchability and high stability, and has low contact impedance, which improves the comfort of wearing ECG electrodes and improves the quality of the collected ECG signals.

[0027] like Figure 1 As shown, an embodiment of the present invention provides a flexible ECG acquisition integrated array, comprising: A flexible substrate 4, wherein the flexible substrate 4 is a substrate formed based on an organic polymer solution; A conductive layer, a part of which is evenly covered on the surface of the flexible substrate 4, and another part of which is embedded in the flexible substrate 4; the conductive layer is a conductive layer formed by mixing a two-dimensional layered conductive material 2 and a one-dimensional linear conductive material 3; like Figure 3 As shown, the conductive layer includes: a plurality of lead channels for collecting lead ECG; wherein each lead channel includes a round probe 5, a connecting wire 6 and a pad 7, and the round probe 5 is connected to the pad 7 via the connecting wire 6.

[0028] As an example, the multiple lead channels in this embodiment are divided into two parts, the number of lead channels in the first part is 6, and the number of lead channel electrodes in the second part is 4; in the scenario of flexible ECG acquisition integrated array application, the 6 lead channels correspond to the 6 electrodes at the chest leads during the standard 12-lead ECG detection of the human body, and the 4 lead channels correspond to the limb lead electrodes of the human body.

[0029] like Figure 4 As shown, Figure 4 FIG. 2 is a schematic diagram of collecting standard 12-lead ECG signals of a human body using the flexible ECG collection integrated array in this embodiment; FIG. Figure 5 As shown, Figure 5 The diagram in the figure is a schematic diagram of the corresponding 12-lead ECG signal collected.

[0030] This embodiment achieves the following technical effects through the above technical solution: This embodiment proposes a flexible ECG acquisition integrated array, which can be used for the acquisition of multi-lead ECG signals of human body. When acquiring multi-lead (for example, 12-lead) ECG signals, since the flexible ECG acquisition integrated array has a certain integrated design, it can avoid the problems of complicated operation and uncomfortable wearing caused by multiple lead wires. The flexible ECG acquisition integrated array provided in this embodiment has flexibility, high conductivity, stretchability and high stability, and has low contact impedance, which improves the comfort of wearing ECG electrodes and improves the quality of the collected ECG signals.

[0031] Exemplary Methods like Figure 2 As shown, an embodiment of the present invention provides a method for preparing a flexible ECG acquisition integrated array, comprising the following steps: Step S100, providing a substrate, and etching a preset integrated array pattern on the substrate to obtain an etched substrate; Step S200, ultrasonically treating the two-dimensional conductive nanomaterial solution to obtain a uniform two-dimensional layered solution; Step S300, mixing the two-dimensional layered solution with a one-dimensional conductive material, and then performing ultrasonic treatment to obtain a uniform conductive mixed solution; Step S400, drop-coating the conductive mixed solution on the etched substrate, and annealing and drying to form a conductive layer to obtain a pre-treated substrate; Step S500, spin-coating an organic polymer solution on the pre-processed substrate, and performing drying and annealing to obtain a flexible ECG acquisition integrated array on the pre-processed substrate.

[0032] In this embodiment, the flexible ECG acquisition integrated array preparation method is used to prepare the flexible ECG acquisition integrated array as described above; the flexible ECG acquisition integrated array preparation method is simple and easy to operate, and is convenient for large-scale production.

[0033] The flexible ECG acquisition integrated array prepared by the preparation method provided in this embodiment has the characteristics of ultra-thinness, flexibility, high conductivity, stretchability and low contact impedance. Based on these characteristics, when wearing the flexible ECG acquisition integrated array, it can avoid discomfort to the human body, and can achieve high-quality multi-lead ECG signals even in motion. At the same time, the flexible ECG acquisition integrated array provided in this embodiment can be reused.

[0034] In this embodiment, the provided substrate can be any one of a silicon wafer, a glass wafer, a copper wafer and a stainless steel wafer, but is not limited thereto. The size of the substrate can be set according to the desired integrated array pattern, for example, the size of the substrate is 20*30 mm.

[0035] Specifically, it is necessary to etch an integrated array pattern on the provided substrate to obtain a specific substrate, wherein the array pattern is an integrated pattern of 6 lead channels integrated together, and 4 lead channel patterns are separately set; each lead channel includes a round probe, a connecting wire, and a pad. In this embodiment, the pattern of the integrated array on the specific substrate is made by silicon etching, and a lead channel with a depth of 30-80 μm is formed on the substrate. After etching the integrated array pattern, the obtained specific substrate needs to be cleaned, and the cleaning agent required for cleaning can be selected from one or more of alcohol, acetone, isopropyl alcohol, etc. for cleaning to ensure that the surface of the specific substrate is in a clean state.

[0036] In this embodiment, after cleaning the specific substrate, a two-dimensional conductive nanomaterial solution needs to be prepared; the two-dimensional conductive nanomaterial solution is obtained by mixing the two-dimensional conductive nanomaterial and a solvent; wherein the two-dimensional conductive nanomaterial (i.e., two-dimensional conductive nanosheet) can be a single layer or multilayer structure, and the size of the single layer is 1000-10000nm; and the two-dimensional conductive nanomaterial can be selected from one or more of two-dimensional nanosheets such as graphene, MXene materials, niobium arsenide nanobelts, molybdenum disulfide, and black phosphorus. The solvent of the two-dimensional conductive nanomaterial solution is deionized water or alcohol; the solvent can be configured with a corresponding concentration according to the required concentration of the two-dimensional conductive nanosheet.

[0037] Specifically, in one implementation of the present embodiment, the two-dimensional conductive nanomaterial solution is ultrasonically treated to obtain a uniform two-dimensional layered solution, including: adding a solvent of a preset concentration (for example, a concentration of 8%) to the two-dimensional conductive nanomaterial, and then performing a first ultrasonic treatment on the two-dimensional conductive nanomaterial solution to make the solute distribution in the two-dimensional conductive nanomaterial solution more uniform, thereby obtaining the uniform two-dimensional layered solution; wherein the power of the first ultrasonic treatment is 60-80 W, and the ultrasonic duration is 8-25 min.

[0038] In this embodiment, after preparing the two-dimensional conductive nanomaterial solution, it is also necessary to prepare a one-dimensional conductive material, which can be selected from one or more one-dimensional conductive nanomaterials such as carbon nanotubes, metal nanowires, zinc oxide nanowires and silver nanowires; the one-dimensional conductive nanowire has a diameter of 50-100nm and a length of 1-30μm.

[0039] After obtaining the uniform two-dimensional layered solution and the one-dimensional conductive material, the two can be mixed to obtain a conductive mixed solution.

[0040] Specifically, in one implementation of the present embodiment, the two-dimensional layered solution is mixed with a one-dimensional conductive material, and then subjected to ultrasonic treatment to obtain a uniform conductive mixed solution, comprising: adding the one-dimensional conductive material to the two-dimensional layered solution, and conducting a second ultrasonic treatment to obtain the uniform conductive mixed solution; wherein the purpose of the second ultrasonic treatment is to allow the one-dimensional conductive nanowires and the two-dimensional conductive nanosheets to be evenly distributed in the solvent, in preparation for the subsequent formation of a uniform and stable three-dimensional conductive network; therefore, the power of the second ultrasonic treatment is 80-100 W, and the ultrasonic duration is 15-40 min.

[0041] In this embodiment, after obtaining a uniform conductive mixed solution, the conductive mixed solution can be dripped on the etched substrate, and annealed and dried to form a conductive layer to obtain a pre-treated substrate; this is the first annealing and drying treatment, the annealing and drying temperature is 45-50°C, the time is 2-3h, the purpose is to allow the conductive solution to be deposited on the specific substrate to form a conductive layer. And the amount of conductive solution dripped on the specific substrate is determined according to the thickness of the required conductive layer. And the range of dripping is the pattern on the specific substrate, and the lead channel on the integrated array pattern needs to be coated with a conductive solution to ensure the conductive integrity of the entire lead channel.

[0042] In this embodiment, after obtaining the pre-treated substrate, the organic polymer solution can be spin-coated on the pre-treated substrate, and dried and annealed to obtain a flexible ECG acquisition integrated array on the pre-treated substrate; wherein the organic polymer solution (i.e., the solution required for the flexible substrate) is one or more of polyvinylidene fluoride, polydimethylsiloxane, hydrogenated styrene-butadiene block copolymer and polyurethane; when spin-coating the organic polymer solution, the spin-coating speed is 800-1000 rpm, and then the spin-coated organic polymer solution can be annealed and dried, which is the second annealing and drying treatment, the annealing temperature is 60-95°C, the time is 60-90min, the purpose is to form an ultra-thin flexible substrate.

[0043] Finally, the flexible ECG acquisition integrated array can be peeled off from the specific substrate using methods such as alcohol or ultrasound to obtain a flexible ECG acquisition integrated array.

[0044] As an example, in a preparation scenario of this embodiment, the preparation method of the flexible ECG acquisition integrated array includes the following steps: a. Provide a substrate: the substrate is used for preparing a flexible ECG acquisition integrated array.

[0045] b. Designing an integrated array pattern for ECG collection on a substrate, including two parts, such as Figure 3 As shown, the first part is an integrated design of 6 lead channels, and the second part is 4 separately set lead channels; each lead channel includes a round probe, a connecting wire and a welding pad; the 6 lead channels designed together in the first part correspond to the 6 electrodes at the chest leads during the standard 12-lead ECG detection of the human body, and the 4 lead channels designed in the second part correspond to the lead electrodes at the limbs of the human body.

[0046] c. Use silicon etching method to etch the designed flexible ECG collection integrated array pattern on the substrate to obtain a specific substrate.

[0047] d. Clean the specific substrate by ultrasonic cleaning with anhydrous ethanol, acetone and isopropanol in sequence, with the ultrasonic parameters being 100w for 10min.

[0048] e. Add 2 mg of two-dimensional conductive nanosheet MXene into a glass bottle, add 10 mL of deionized water and mix, and perform the first ultrasonic treatment (power 80 W, ultrasonication for 10 min) to obtain a two-dimensional layered solution.

[0049] f. Add 30 mg of AgNW into the two-dimensional layered solution and perform ultrasonic crushing at a power of 100 W for 20 min. Finally, a uniform AgNW / MXene conductive mixed solution is obtained, and the concentration ratio of the two is 3:0.2.

[0050] g. Preparation of organic polymer solution-SEBS solution: Put hydrogenated styrene-butadiene block copolymer (StyreneEthylene Butylene Styrene, SEBS, white foam) into a grinding bowl for grinding, use an electronic balance to weigh out 3750mg of ground SBES powder, put it in a glass bottle, and then operate in a glove box, add 15ml of dichlorobenzene to the glass bottle containing SEBS, then add magnetic beads, and then place it on a magnetic heating stirring table for heating and stirring, the heating temperature is 60℃, the stirring speed is 450r / min, and the stirring time is 1h. Finally, a 250mg / mL SEBS organic polymer solution is obtained.

[0051] h. Take 4 mL of the conductive solution and evenly coat it on the pattern of the specific substrate, and anneal it at 47°C for 1.5 h to form a conductive layer to obtain a pretreated substrate.

[0052] i. Take 4.5mL of the organic polymer solution-SEBS solution prepared above and spin-coat it on the pretreated substrate at a speed of 850rpm / min for 30s. SEBS covers the surface of the conductive layer and penetrates into it. Then, place the silicon wafer with SEBS spin-coated on a heating table and anneal at 90℃ for 1.5h. Finally, use alcohol to peel off the flexible ECG acquisition integrated array from the substrate to obtain a flexible ECG acquisition integrated array.

[0053] j. The conductive layer of the flexible ECG acquisition array, namely the three-dimensional composite conductive network structure, has a thickness of 1-2 μm, and the elastic base layer has a thickness of about 30 μm.

[0054] like Figure 4 As shown, Figure 4 FIG. 2 is a schematic diagram of collecting standard 12-lead ECG signals of a human body using the flexible ECG collection integrated array in this embodiment; FIG. Figure 5 As shown, Figure 5The diagram in the figure is a schematic diagram of the corresponding 12-lead ECG signal collected.

[0055] This embodiment achieves the following technical effects through the above technical solution: This embodiment proposes a method for preparing a flexible ECG acquisition integrated array. The prepared flexible ECG acquisition integrated array can be used for the acquisition of multi-lead ECG signals of human body. When acquiring multi-lead (for example, 12-lead) ECG signals, since the flexible ECG acquisition integrated array has a certain integrated design, it can avoid the problems of complicated operation and wearing discomfort caused by multiple lead wires. The flexible ECG acquisition integrated array prepared in this embodiment has flexibility, high conductivity, stretchability and high stability, and has low contact impedance, which improves the comfort of wearing ECG electrodes and improves the quality of the collected ECG signals.

[0056] Those skilled in the art can understand that all or part of the processes in the above-mentioned embodiments can be implemented by instructing related hardware through a computer program, and the computer program can be stored in a non-volatile storage medium. When the computer program is executed, it can include the processes of the embodiments of the above-mentioned methods. Among them, any reference to memory, storage, database or other media used in the embodiments provided by the present invention can include non-volatile and volatile memory.

[0057] In summary, the present invention provides a flexible ECG acquisition integrated array and a preparation method, including: a flexible substrate, the flexible substrate is a substrate formed based on an organic polymer solution; a conductive layer, a part of the conductive layer is evenly covered on the surface of the flexible substrate, and the other part of the conductive layer is embedded in the flexible substrate; the conductive layer is a conductive layer formed by mixing a two-dimensional layered conductive material and a one-dimensional linear conductive material; the conductive layer includes: a plurality of lead channels for lead ECG acquisition; wherein each lead channel includes a round probe, a connecting wire and a pad, and the round probe is connected to the pad through a connecting wire. The flexible ECG acquisition integrated array provided by the present invention has flexibility, high conductivity, stretchability and high stability, and has a low contact impedance, which improves the comfort of wearing ECG electrodes and improves the quality of the collected ECG signals.

[0058] It should be understood that the application of the present invention is not limited to the above examples. For ordinary technicians in this field, improvements or changes can be made based on the above description. All these improvements and changes should fall within the scope of protection of the claims attached to the present invention.

Claims

1. A flexible ECG acquisition integrated array, characterized in that: include: A flexible substrate, wherein the flexible substrate is a substrate formed based on an organic polymer solution; A conductive layer, a portion of which evenly covers the surface of the flexible substrate, and another portion of which is embedded in the flexible substrate; The conductive layer is a conductive layer formed by mixing a two-dimensional layered conductive material and a one-dimensional linear conductive material; The conductive layer includes: a plurality of lead channels for collecting lead electrocardiograms; wherein each lead channel includes a round probe, a connecting wire and a pad, and the round probe is connected to the pad via the connecting wire.

2. A method for preparing a flexible ECG acquisition integrated array, used to prepare the flexible ECG acquisition integrated array as claimed in claim 1, characterized in that: include: Providing a substrate, and etching a preset integrated array pattern on the substrate to obtain an etched substrate; Ultrasonic treatment is performed on the two-dimensional conductive nanomaterial solution to obtain a uniform two-dimensional layered solution; The two-dimensional layered solution is mixed with a one-dimensional conductive material, and then subjected to ultrasonic treatment to obtain a uniform conductive mixed solution; Drop-coating the conductive mixed solution on the etched substrate, and performing annealing and drying to form a conductive layer to obtain a pre-treated substrate; The organic polymer solution is spin-coated on the pre-processed substrate, and then dried and annealed to prepare a flexible electrocardiogram collection integrated array on the pre-processed substrate.

3. The method for preparing a flexible ECG acquisition integrated array according to claim 2, characterized in that: The preset integrated array pattern includes a first pattern and a second pattern; The first pattern is a pattern integrated by 6 lead channels, wherein each lead channel includes a round probe, a connecting wire and a pad, and the round probe is connected to the pad through the connecting wire; The second pattern is a pattern of four separate lead channels.

4. The method for preparing a flexible ECG acquisition integrated array according to claim 2, characterized in that: The solvent of the two-dimensional conductive nanomaterial solution is deionized water or alcohol; The two-dimensional conductive nanomaterial solution is subjected to ultrasonic treatment to obtain a uniform two-dimensional layered solution, comprising: After adding a solvent of a preset concentration into the two-dimensional conductive nanomaterial, the two-dimensional conductive nanomaterial solution is subjected to a first ultrasonic treatment to make the solute distribution in the two-dimensional conductive nanomaterial solution more uniform, thereby obtaining the uniform two-dimensional layered solution; wherein the power of the first ultrasonic treatment is 60-80W, and the ultrasonic duration is 8-25min.

5. The method for preparing a flexible ECG acquisition integrated array according to claim 4, characterized in that: The two-dimensional conductive nanomaterial is one or more of graphene, MXene material, niobium arsenide nanoribbon, molybdenum disulfide and black phosphorus.

6. The method for preparing a flexible ECG acquisition integrated array according to claim 4, characterized in that: The two-dimensional layered solution is mixed with a one-dimensional conductive material, and then subjected to ultrasonic treatment to obtain a uniform conductive mixed solution, comprising: adding the one-dimensional conductive material into the two-dimensional layered solution, and performing a second ultrasonic treatment to obtain the uniform conductive mixed solution; The power of the second ultrasonic treatment is 80-100 W, and the ultrasonic duration is 15-40 min; the one-dimensional conductive material is one or more of carbon nanotubes, metal nanowires, zinc oxide nanowires and silver nanowires.

7. The method for preparing a flexible ECG acquisition integrated array according to claim 2, characterized in that: The annealing and drying temperature of the pre-treated substrate is 45-50° C., and the time is 2-3 hours.

8. The method for preparing a flexible ECG acquisition integrated array according to claim 2, characterized in that: The organic polymer solution is one or more of polyvinylidene fluoride, polydimethylsiloxane, hydrogenated styrene-butadiene block copolymer and polyurethane.

9. The method for preparing a flexible ECG acquisition integrated array according to claim 2, characterized in that: The organic polymer solution is spin-coated on the pre-treated substrate at a spin-coating speed of 800-1000 rpm.

10. The method for preparing a flexible ECG acquisition integrated array according to claim 2, characterized in that: The temperature for annealing and drying the pre-treated substrate after spin coating the organic polymer solution is 60-95° C. and the time is 50-90 minutes.

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