OLED diagnosis and treatment integrated system and method for photodynamic precise treatment

Abstract

According to the OLED diagnosis and treatment integrated system and method for photodynamic precise treatment, treatment light field customization and regulation and control functions based on an OLED are achieved, light field distribution is regulated and controlled through fluorescence feedback, the optimal treatment effect is achieved, and preoperative detection and intraoperative monitoring of photosensitizer fluorescence and autofluorescence are supported. The phototherapy module uses an OLED flexible panel to carry out phototherapy, an OLED is divided into a plurality of independent small square blocks, each small square block is provided with a hole for embedding a fluorescent module, and other parts are used for phototherapy; the fluorescence module acquires a fluorescence signal at the focus; the user module communicates with the control module through the communication module; the control module acquires user module information and fluorescence signals, controls the driving module to realize light field customization and regulation, judges a focus range according to fluorescence distribution, adjusts illumination intensity according to fluorescence intensity, and realizes precise treatment of the focus; the power supply module supplies power to the diagnosis and treatment integrated system.

Description

Technical Field

[0001] The present invention relates to the technical field of photoelectric detection, and in particular to an OLED (organic diode) diagnosis and treatment integrated system for photodynamic precision therapy, and a method adopted by the OLED diagnosis and treatment integrated system for photodynamic precision therapy. Background Art

[0002] Photodynamic therapy is a new type of minimally invasive phototherapy method. It administers photosensitizers to the lesions by intravenous injection or local application, and uses light of a specific wavelength to activate the photosensitizers, causing the lesion area to produce cytotoxic reactive oxygen species, thereby killing lesion cells. It has the advantages of high selectivity and low trauma.

[0003] However, the spatial distribution of photosensitizers in the body is difficult to control accurately. Both lesions and normal tissues may be enriched with photosensitizers at different concentrations. If the range of therapeutic illumination cannot accurately cover the lesion area, it may cause damage to normal tissues, or the treatment may fail due to insufficient therapeutic light dose in the lesion area. The excitation light source used in traditional photodynamic therapy is mainly laser, and the laser output is usually a circular spot. However, the size and shape of the lesion are usually irregularly distributed, and the circular spot is difficult to accurately cover the lesion area, which can easily lead to inaccurate therapeutic illumination range, greatly limiting the accuracy of photodynamic therapy. In addition, photodynamic therapy currently mainly determines the optimal irradiation time and irradiation intensity through clinical experience, and cannot timely adjust the therapeutic light dose by real-time monitoring of photosensitizer changes. In order to achieve personalized treatment and continuously improve the safety and effectiveness of photodynamic therapy, it is urgent to develop a photodynamic therapy device with photosensitizer monitoring, light field customization and regulation functions to achieve efficient and safe selective treatment. Summary of the invention

[0004] In order to overcome the defects of the prior art, the technical problem to be solved by the present invention is to provide an OLED integrated diagnosis and treatment system for photodynamic precision therapy, which has the function of customizing and regulating the therapeutic light field based on OLED, regulates the light field distribution through fluorescence feedback to achieve the best treatment effect, and supports preoperative detection and intraoperative monitoring of photosensitizer fluorescence and autofluorescence.

[0005] The technical solution of the present invention is: this OLED diagnosis and treatment integrated system for photodynamic precision treatment includes: a phototherapy module, a fluorescence module, a control module, a drive module, a communication module, a user module and a power module;

[0006] The phototherapy module uses an OLED flexible panel for phototherapy, in which the OLED is divided into multiple independent small squares, each of which is designed with a hole to embed the fluorescent module, and the rest is used for phototherapy; the fluorescent module obtains the fluorescent signal at the lesion; the user module communicates with the control module through the communication module; the control module obtains the user module information and the fluorescent signal, controls the drive module to realize light field customization and regulation, determines the lesion range according to the fluorescence distribution, and adjusts the light intensity according to the fluorescence intensity to achieve precise treatment of the lesion; the power module supplies power to the integrated diagnosis and treatment system.

[0007] The phototherapy module of the present invention uses an OLED flexible panel for phototherapy, wherein the OLED is divided into multiple independent small squares, each small square is designed with a hole to embed the fluorescent module, and the rest is used for phototherapy; the fluorescent module obtains the fluorescent signal at the lesion; the user module communicates with the control module through the communication module, the control module obtains the user module information and the fluorescent signal, and controls the drive module to realize light field customization and regulation, judges the lesion range according to the fluorescence distribution, and adjusts the light intensity according to the fluorescence intensity to achieve precise treatment of the lesion; the power module supplies power to the entire integrated diagnosis and treatment phototherapy board; therefore, the system has the function of customizing and regulating the therapeutic light field based on OLED, regulates the light field distribution through fluorescence feedback, achieves the best treatment effect, and supports preoperative detection and intraoperative monitoring of photosensitizer fluorescence and autofluorescence.

[0008] Also provided is an OLED diagnosis and treatment integrated method for photodynamic precision therapy, which includes the following steps:

[0009] (1) Fix the integrated diagnosis and treatment phototherapy board on the patient and turn on the power;

[0010] (2) Setting the parameters of initial light intensity, illumination time, and illumination range on the user module to customize the light field;

[0011] (3) Conduct fluorescence monitoring and adjust the light intensity, illumination range, and illumination time according to the fluorescence information;

[0012] (4) Use the user unit to perform preoperative detection and intraoperative monitoring of photosensitizer fluorescence and autofluorescence and adjust lighting parameters. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 A schematic structural diagram of an OLED flexible panel of an OLED diagnosis and treatment integrated system for photodynamic precision therapy according to the present invention is shown.

[0014] Figure 2 A structural schematic diagram of a phototherapy module of an OLED diagnosis and treatment integrated system for photodynamic precision therapy according to the present invention is shown.

[0015] Figure 3A schematic structural diagram of a fluorescent module of an OLED diagnosis and treatment integrated system for photodynamic precision therapy according to the present invention is shown.

[0016] Figure 4 A system schematic diagram of an OLED diagnosis and treatment integrated system for photodynamic precision therapy according to the present invention is shown.

[0017] Figure 5 A schematic diagram of the main interface displayed on the user module of the OLED diagnosis and treatment integrated system for photodynamic precision therapy according to the present invention is shown.

[0018] Figure 6 A schematic diagram of a monitoring interface displayed on a user module of an OLED integrated diagnosis and treatment system for photodynamic precision therapy according to the present invention is shown.

[0019] Figure 7 A schematic diagram of an embodiment of a port wine stain of an OLED diagnosis and treatment integrated system for photodynamic precision treatment according to the present invention is shown.

[0020] Figure 8 A schematic diagram of an embodiment of basal cell carcinoma of an OLED diagnosis and treatment integrated system for photodynamic precision treatment according to the present invention is shown. DETAILED DESCRIPTION

[0021] In order to enable those skilled in the art to better understand the scheme of the present invention, the technical scheme in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the present invention.

[0022] It should be noted that the term "comprises" and any variations in the specification and claims of the present invention and the above-mentioned drawings are intended to cover non-exclusive inclusions. For example, a process, method, apparatus, product or equipment that includes a series of steps or units is not necessarily limited to those steps or units clearly listed, but may include other steps or units that are not clearly listed or are inherent to these processes, methods, products or equipment.

[0023] like Figure 4 As shown, the OLED diagnosis and treatment integrated system for photodynamic precision therapy includes: a phototherapy module 4, a fluorescence module 3, a control module 12, a drive module 11, a communication module 13, a user module 5 and a power module 15;

[0024] Light therapy module (such as Figure 2 As shown) using OLED flexible panels (such as Figure 1 As shown in FIG. 1 ), the OLED is divided into a plurality of independent small blocks, each of which is designed with a hole to embed a fluorescent module (such as Figure 3 As shown in the figure, the rest is used for phototherapy; the fluorescence module obtains the fluorescence signal at the lesion; the user module communicates with the control module through the communication module; the control module obtains the user module information and the fluorescence signal, controls the drive module to realize the customization and regulation of the light field, determines the range of the lesion according to the fluorescence distribution, adjusts the light intensity according to the fluorescence intensity, and realizes the precise treatment of the lesion; the power module supplies power to the integrated diagnosis and treatment system.

[0025] The phototherapy module of the present invention uses an OLED flexible panel for phototherapy, wherein the OLED is divided into multiple independent small squares, each small square is designed with a hole to embed the fluorescent module, and the rest is used for phototherapy; the fluorescent module obtains the fluorescent signal at the lesion; the user module communicates with the control module through the communication module, the control module obtains the user module information and the fluorescent signal, and controls the drive module to realize light field customization and regulation, judges the lesion range according to the fluorescence distribution, and adjusts the light intensity according to the fluorescence intensity to achieve precise treatment of the lesion; the power module supplies power to the entire integrated diagnosis and treatment phototherapy board; therefore, the system has the function of customizing and regulating the therapeutic light field based on OLED, regulates the light field distribution through fluorescence feedback, achieves the best treatment effect, and supports preoperative detection and intraoperative monitoring of photosensitizer fluorescence and autofluorescence.

[0026] Preferably, the phototherapy module uses a perforated flexible OLED light screen, wherein the perforated OLED is divided into multiple independent small squares, each small square is designed with a hole for embedding the fluorescent module, and the remaining part can emit 532nm or 630nm single-wavelength narrow-band light as a therapeutic light source for photodynamic therapy.

[0027] Preferably, the fluorescence module includes a light excitation unit 31 and a light sensing unit 32; the light excitation unit uses a 405nm micro light emitting diode (Micro LED) to excite the fluorescence of the lesion tissue, and the light sensing unit uses a micro photodiode (Micro PD) to receive the excited fluorescence signal.

[0028] Preferably, the communication module WIFI 131 or the USB interface 132 is connected to the user module to perform data interaction.

[0029] Preferably, the control module receives the fluorescence signal input by the fluorescence module and the light field parameters input by the communication module, determines the range of the lesion according to the range of the fluorescence signal, analyzes the fluorescence intensity distribution to guide the illumination intensity of different areas, and can also customize the light field according to the light field parameters; the driving module receives the input parameters of the control module, controls the phototherapy module according to the parameters, and adjusts its illumination range, illumination intensity and illumination time.

[0030] Preferably, the power module uses a lithium-ion battery, which is charged through the charging interface 151 to power the integrated diagnosis and treatment phototherapy board.

[0031] Preferably, the integrated diagnosis and treatment phototherapy board, viewed from top to bottom in the direction of vertical illumination of the OLED, comprises: a flexible base layer 141 , a diagnostic phototherapy layer 142 and a light uniforming bonding layer 143 .

[0032] Preferably, the flexible substrate layer uses soft insulating supporting materials such as polyimide or polyetheretherketone materials, and embeds the power module, control module, drive module and communication module on the flexible substrate; the diagnostic phototherapy layer is an OLED divided into many small square areas, each area is designed with a hole for embedding the fluorescent module, and the rest is the phototherapy module; the uniform light bonding layer uses a skin-friendly soft polyurethane film or silicone material, and achieves a uniform light effect through surface design.

[0033] Preferably, the fixing device 2 of the integrated diagnosis and treatment phototherapy board can be made of medical tape, medical patch and fixing ring to fix the integrated diagnosis and treatment phototherapy board on the patient.

[0034] like Figure 6 As shown, an OLED diagnosis and treatment integrated method for photodynamic precision therapy is also provided, which includes the following steps:

[0035] (1) Fix the integrated diagnosis and treatment phototherapy board on the patient and turn on the power;

[0036] (2) Setting the parameters of initial light intensity, illumination time, and illumination range on the user module to customize the light field;

[0037] (3) Conduct fluorescence monitoring and adjust the light intensity, illumination range, and illumination time according to the fluorescence information;

[0038] (4) Use the user unit to perform preoperative detection and intraoperative monitoring of photosensitizer fluorescence and autofluorescence and adjust lighting parameters.

[0039] The specific embodiments of the present invention are described in detail below.

[0040] Example 1: The lesion area is a facial port wine stain

[0041] This embodiment provides an integrated diagnosis and treatment system for photodynamic therapy used on the face. Figure 7 As shown, first, the flexible phototherapy device is fixed on the port-wine stain area of ​​the face by a medical patch, so that the integrated diagnosis and treatment phototherapy board 1 covers the port-wine stain, and is deformed by pressing so that the outer curve of the shape of the integrated diagnosis and treatment phototherapy board fits the facial curve of the user.

[0042] Then set the treatment parameters in the main interface of the user module, such as Figure 5 As shown, the wavelength is set to 532nm and the illumination intensity is set to 70%. In the "Illumination Range" window, import the port wine stain lesion model to obtain the lesion area, click the "Enable" button to generate the illumination range corresponding to the lesion, and click the "Adjust" button to manually modify the generated illumination range.

[0043] After the phototherapy parameters are set, the photosensitizer is then injected into the body intravenously. Click "Monitoring Mode" to enter the monitoring interface. Click the "Start" button, and the fluorescence module starts working, emitting an excitation light source with a wavelength of 405nm. When the photosensitizer reaches the lesion, it will be stimulated to emit a fluorescent signal to achieve the purpose of monitoring the fluorescent signal. When the fluorescent signal meets the requirements, that is, the photosensitizer concentration reaches the therapeutic concentration, return to the main interface, click the "Start" button, and the phototherapy begins. During the phototherapy process, the control module receives the fluorescent signal fed back by the fluorescence module, and instructs the drive module to adjust the light intensity and illumination time in each small square on the phototherapy unit, automatically adjusts the light field distribution, and achieves the best treatment effect. At the same time, you can click "Monitoring Mode" to monitor the distribution diagram of fluorescence intensity and phototherapy intensity in real time to further guide the treatment.

[0044] Example 2: Lesion area is facial basal cell carcinoma

[0045] This embodiment provides an integrated diagnosis and treatment system for photodynamic therapy used on the face. Figure 8 As shown, first, the flexible phototherapy device is fixed to the basal cell carcinoma area of ​​the face with medical tape, so that the diagnosis and treatment integrated phototherapy board 1 covers the basal cell carcinoma, and is deformed by pressing so that the outer curve of the shape of the diagnosis and treatment integrated phototherapy board fits the facial curve of the user.

[0046] Then set the treatment parameters in the main interface of user module 5, such as Figure 5 As shown, the wavelength is set to 630nm and the illumination intensity is set to 70%. In the "Illumination Range" window, import the basal cell carcinoma model to obtain the lesion area, click the "Enable" button to generate the illumination range corresponding to the lesion, and click the "Adjust" button to manually modify the generated illumination range.

[0047] After the phototherapy parameters are set, the photosensitizer is then injected into the body intravenously. Click "Monitoring Mode" to enter the monitoring interface. Click the "Start" button, and the fluorescence module starts working, emitting an excitation light source with a wavelength of 405nm. When the photosensitizer reaches the lesion, it will be stimulated to emit a fluorescent signal to achieve the purpose of monitoring the fluorescent signal. When the fluorescent signal meets the requirements, that is, the photosensitizer concentration reaches the therapeutic concentration, return to the main interface, click the "Start" button, and the phototherapy begins. During the phototherapy process, the control module receives the fluorescent signal fed back by the fluorescence module, and instructs the drive module to adjust the light intensity and illumination time in each small square on the phototherapy unit, automatically adjusts the light field distribution, and achieves the best treatment effect. At the same time, you can click "Monitoring Mode" to monitor the distribution diagram of fluorescence intensity and phototherapy intensity in real time to further guide the treatment.

[0048] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Any simple modification, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention are still within the protection scope of the technical solution of the present invention.

Claims

1. An OLED integrated diagnosis and treatment system for photodynamic precision therapy, characterized by: It includes: A light therapy module (4), a fluorescence module (3), a control module (12), a drive module (11), a communication module (13), a user module (5) and a power module (15); The phototherapy module uses an OLED flexible panel for phototherapy, where the OLED is divided into multiple independent small blocks, each of which is designed with a hole to embed the fluorescent module, and the rest is used for phototherapy; the fluorescent module obtains the fluorescent signal at the lesion; the user module communicates with the control module through the communication module; the control module obtains the user module information and fluorescent signal, controls the drive module to customize and regulate the light field, determines the lesion range according to the fluorescence distribution, and adjusts the light intensity according to the fluorescence intensity to achieve precise treatment of the lesion; The power module provides power for the integrated diagnosis and treatment system.

2. The OLED diagnosis and treatment integrated system for photodynamic precision therapy according to claim 1, characterized in that: The phototherapy module uses a perforated flexible OLED light screen, wherein the perforated OLED is divided into a plurality of independent small squares, and the remaining part emits 532nm or 630nm single wavelength narrow band light as a therapeutic light source for photodynamic therapy.

3. The OLED diagnosis and treatment integrated system for photodynamic precision therapy according to claim 2, characterized in that: The fluorescence module comprises a light excitation unit (31) and a light sensing unit (32); the light excitation unit uses a 405nm micro-light emitting diode to excite the fluorescence of the lesion tissue, and the light sensing unit uses a micro-photodiode to receive the excited fluorescence signal.

4. The OLED diagnosis and treatment integrated system for photodynamic precision therapy according to claim 3, characterized in that: The communication module uses WIFI (131) or USB interface (132) to connect to the user module.

5. The OLED diagnosis and treatment integrated system for photodynamic precision therapy according to claim 4, characterized in that: The control module receives the fluorescence signal input by the fluorescence module and the light field parameters input by the communication module, determines the range of the lesion according to the range of the fluorescence signal, analyzes the fluorescence intensity distribution to guide the illumination intensity of different areas, or customizes the light field according to the light field parameters; the driving module receives the input parameters of the control module, controls the phototherapy module according to the parameters, and adjusts its illumination range, illumination intensity and illumination time.

6. The OLED diagnosis and treatment integrated system for photodynamic precision therapy according to claim 5, characterized in that: The power module uses a lithium-ion battery, which is charged through a charging interface (151) to power the integrated diagnosis and treatment phototherapy board.

7. The OLED diagnosis and treatment integrated system for photodynamic precision therapy according to claim 6, characterized in that: The integrated diagnosis and treatment phototherapy board comprises, from top to bottom in the direction of vertical illumination of the OLED, a flexible base layer (141), a diagnosis phototherapy layer (142) and a light uniforming bonding layer (143).

8. The OLED diagnosis and treatment integrated system for photodynamic precision therapy according to claim 7, characterized in that: The flexible base layer uses polyimide or polyetheretherketone material, and the power module, control module, drive module and communication module are embedded in the flexible base layer; the uniform light bonding layer uses polyurethane film or silicone material, and the uniform light effect is achieved through surface design.

9. The OLED diagnosis and treatment integrated system for photodynamic precision therapy according to claim 6, characterized in that: The fixing device (2) of the diagnosis and treatment integrated phototherapy board comprises medical tape, a medical patch and a fixing ring, which fixes the diagnosis and treatment integrated phototherapy board on the patient's body.

10. An OLED diagnosis and treatment integrated method for photodynamic precision therapy, characterized in that: It includes the following steps: (1) Fix the integrated diagnosis and treatment phototherapy board on the patient and turn on the power; (2) Setting the parameters of initial light intensity, illumination time, and illumination range on the user module to customize the light field; (3) Conduct fluorescence monitoring and adjust the light intensity, illumination range, and illumination time according to the fluorescence information; (4) Use the user unit to perform preoperative detection and intraoperative monitoring of photosensitizer fluorescence and autofluorescence and adjust lighting parameters.

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