Radiation system of medical linear accelerator and method thereof

Abstract

The invention relates to a radiation system of a medical linear accelerator and a method thereof, the radiation system comprises a support device, a plurality of accelerators and a control module, the support device can perform multi-dimensional motion and is used for bearing a patient; an accelerator for generating a radiation beam to radiate the patient; the control module is used for controlling the accelerators and the supporting device; through multi-dimensional movement of the supporting device, non-coplanar radiotherapy is carried out on a target treatment target area of a patient by the accelerators located on the patient supporting device, intensity modulated radiation treatment is realized by controlling single opening or combined opening of a plurality of accelerators, and a plurality of radiation beams from the accelerators are configured to be transmitted from different orientations; the structure is simple, and the radiation system of the medical linear accelerator comprises a supporting device and a plurality of accelerators; therefore, any one radiation mode is adopted by a plurality of accelerators, and a plurality of different radiation therapy modes can be realized by selecting a combination mode.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical equipment, and in particular relates to a radiation system and method of a medical linear accelerator. Background Art

[0002] Medical Linear Accelerators refer to products that are composed of treatment heads, accelerating tubes, magnetrons / klystrons, collimators, positioning systems, treatment beds, control systems, modulators, water cooling units and other components, and are used for clinical routine X-ray or electron beam radiotherapy.

[0003] FLASH radiotherapy, also known as ultra-high dose rate radiotherapy, can achieve unique biological effects (normal tissue damage is significantly reduced, while the tumor cell killing effect remains unchanged) by irradiating tumors with a beam (40Gy / s) that is hundreds of times higher than conventional radiotherapy (≈0.4Gy / s). This biological effect was confirmed by the Curie Institute in France in 2014, when ultra-high dose rate and conventional dose rate electron beams were used to irradiate tumor-bearing mice. It was found that the degree of lung fibrosis in the ultra-high dose rate group was generally milder than that in the conventional dose rate group, while the tumor control effect was comparable.

[0004] Although the mechanism of FLASH radiotherapy is unclear, FLASH radiotherapy has rapidly become a hot topic in academia and industry due to its unique advantages. Its main advantages are: 1) Breaking through the current normal tissue tolerance bottleneck in clinical tumor radiotherapy and widening the treatment window; 2) The irradiation time is compressed to milliseconds, greatly improving the treatment speed (the irradiation time of conventional radiotherapy is minutes), and the impact of organ and tumor movement caused by breathing in conventional radiotherapy on radiotherapy can be completely ignored in FLASH radiotherapy.

[0005] There are three main types of radiation for FLASH radiotherapy: electrons, X-rays, and protons. The dose rate of electron beams can easily reach the dose rate required for the FLASH effect, but due to the weak penetration of electrons, it is only suitable for superficial tumors; and the generation of high-energy electron beams requires large accelerators, which are large in size, expensive to build, and not suitable for clinical implementation. Proton accelerators are also large in size, and the development and maintenance costs are high.

[0006] Traditional FLASH delivery has also been primarily focused on the use of protons or electrons, since FLASH therapy appears to require a threshold dose to be reached before the FLASH effect is achieved, and also requires that the overall dose be delivered within a very small time window. In conventional state of the art treatment planning, such as in arc therapy or intensity modulated radiation therapy, the treatment dose is delivered to the tumor from many different angles, and therefore most healthy tissues never reach the threshold dose at which the FLASH dose rate is beneficial. Therefore, in order for FLASH therapy to improve upon state of the art delivery, it is also necessary to deliver doses from multiple angles, and this must be done almost simultaneously. Conventional proton and electron systems are typically too expensive to implement multiple accelerators delivering beams from multiple angles simultaneously. Conventional gantry approaches typically move too slowly between delivery angles to meet FLASH timing constraints.

[0007] In view of the above technical problems, improvements need to be made. Summary of the invention

[0008] The present invention aims to overcome the defects in the above-mentioned prior art and provide a radiation system and method of a medical linear accelerator with a simple and reasonable structure and ingenious design. The radiation system can provide more accurate and stable positioning, and is also more flexible. Different radiation systems can be selected according to actual needs, which simplifies the overall structure of the system and makes the layout simpler and more reliable.

[0009] In order to achieve the above objectives, the technical solution adopted by the present invention is: a radiation system of a medical linear accelerator, comprising a support device, multiple accelerators and a control module, wherein: the support device can perform multi-dimensional movement to carry a patient; the accelerator is used to generate a radiation beam to irradiate the patient; the control module is used to control the multiple accelerators and the support device; through the multi-dimensional movement of the support device, the accelerator located on the patient support device performs non-coplanar radiotherapy on the target treatment target area of ​​the patient, and by controlling multiple accelerators to be turned on individually or in combination, intensity modulated radiation therapy is achieved, wherein the multiple radiation beams from the accelerator are configured to be transmitted from different directions.

[0010] As a preferred embodiment of the present invention, the plurality of accelerators are mounted on a support frame.

[0011] As a preferred embodiment of the present invention, the support frame is rotatable, so that when the support frame rotates, the individual accelerators provide radiation from different angles.

[0012] As a preferred embodiment of the present invention, the radiation system includes electron flash therapy (FLASH), ordinary X-ray radiotherapy, ordinary electron radiotherapy, and X-ray flash therapy (X-ray FLASH).

[0013] As a preferred embodiment of the present invention, the radiation system is an independent radiation module, which can adopt only one of the radiation modes, or a combination of any two or three radiation modes.

[0014] As a preferred embodiment of the present invention, the radiation system adopts a combination of four methods: electronic flash therapy (FLASH), ordinary X-ray radiotherapy, ordinary electronic radiotherapy, and X-ray flash therapy (X-ray FLASH).

[0015] The radiation transfer method of a medical linear accelerator comprises the following steps:

[0016] Step 1: generating radiation at least partially simultaneously in a plurality of accelerators;

[0017] Step 2: Coordinate the movement of electron beam impacts on high intensity targets included in the plurality of accelerators; and transmit radiation from different orientations to target tissue in a patient;

[0018] Step 3: Select a suitable radiation system based on the patient's actual situation and in coordination with the control module.

[0019] As a preferred mode of the delivery method of the present invention, the radiation system includes electron flash therapy (FLASH), ordinary X-ray radiotherapy, ordinary electron radiotherapy, and X-ray flash therapy (X-ray FLASH).

[0020] As a preferred mode of the transmission method of the present invention, the radiation system is an independent radiation module, which can adopt only any one of the radiation modes, or a combination of any two or three radiation modes.

[0021] As a preferred mode of the transmission method of the present invention, the radiation system adopts four combinations.

[0022] The beneficial effects of the present invention are:

[0023] 1. The present invention has a simple structure. The radiation system of the medical linear accelerator includes a supporting device and a plurality of accelerators. Thus, by using any radiation mode of the plurality of accelerators, or by selecting a combination mode, a plurality of different forms of radiotherapy modes can be realized. Moreover, the plurality of accelerators are arranged corresponding to the supporting device, and the multi-dimensional movement of the patient supporting device is coordinated to realize non-coplanar radiotherapy of the patient's target treatment target area, which can more effectively protect normal tissues.

[0024] 2. The present invention is cleverly designed. The radiation system delivery method includes generating photon radiation at least partially or simultaneously in multiple accelerators; coordinating the electron beam impact movement on the high-intensity target included in the multiple accelerators and transmitting photon radiation from different directions to the target tissue of the patient; the transmitted radiation can be coordinated with the medical treatment plan; the multiple accelerators can be operated independently or in any combination of two or three, thereby improving the good treatment effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 is a schematic structural diagram of a radiation system of a medical linear accelerator according to an embodiment of the present invention;

[0026] Reference numerals in the figure: support device 100, accelerator 200, control module 300. DETAILED DESCRIPTION

[0027] The embodiments of the present invention are described in detail below with reference to the accompanying drawings.

[0028] Embodiment 1:

[0029] like Figure 1 As shown, Figure 1 is a structural schematic diagram of a radiation system of a medical linear accelerator according to an embodiment of the present invention; the radiation system of the medical linear accelerator comprises a support device 100, a plurality of accelerators 200 and a control module 300, wherein: the support device 100 can perform multi-dimensional movement and is used to carry a patient; the accelerator 200 is used to generate a radiation beam to irradiate the patient; the control module 300 is used to control the plurality of accelerators 200 and the support device 100; through the multi-dimensional movement of the support device 100, the accelerator 200 located on the patient support device 100 performs non-coplanar radiotherapy on the target treatment target area of ​​the patient, and by controlling the plurality of accelerators 200 to be turned on individually or in combination, intensity modulated radiation therapy is achieved, wherein the plurality of radiation beams from the accelerator 200 are configured to be transmitted from different directions.

[0030] In one exemplary implementation, multiple accelerators 200 generate particles (e.g., photons, etc.) having radiation characteristics. In one embodiment, the elementary particles travel in substantially the same direction and are included in the radiation beam. In one exemplary implementation, the accelerator 200 can output and extract particles with a specified energy relative to a continuous wave. In one exemplary implementation, the accelerator 200 can be pulsed.

[0031] In one embodiment, the control module 300 receives and instructs the execution of a prescribed treatment plan. In an exemplary implementation, the control module 300 includes a computer system having a processor, a memory, and a user interface component (e.g., a keyboard, a mouse, a display, etc.). The control module 300 can control the parameters and operations of the accelerator 200 and the support device 100, including parameters such as the energy, intensity, direction, size, and / or shape of the beam. The control module 300 can receive data related to the operation of the accelerator 200 and control the components according to the data received. The data can be included in the prescribed treatment plan. In one embodiment, the control module 300 receives information and analyzes the execution and treatment provided by the radiation system of the medical linear accelerator. In one embodiment, the control module 300 can guide the adjustment of the radiation system of the medical linear accelerator based on the analysis of dose and dose rate.

[0032] In the radiation system of the medical linear accelerator of this embodiment, the accelerating tube in the accelerator 200 adopts a room temperature medium and high energy linear accelerating tube, which is configured to accelerate electrons to 10 MeV and generate radiation after hitting the target.

[0033] High-energy medical electron linear accelerator: (1) It provides two levels of X-radiation, commercially known as the two-photon mode. Some products can even provide three levels of X-radiation, known as the three-photon mode. The purpose of the multi-level setting is to adjust the depth dose characteristics of X-radiation, because the combination of high and low energy levels of X-radiation is equivalent to adjusting the energy.

[0034] (2) It can provide higher energy electron radiation. Generally, electron radiation is divided into 5-9 levels, with energy up to 20-25 MeV, which expands the treatment depth range of superficial tumors (2-7 cm).

[0035] As an optional implementation of this embodiment, the accelerator 200 described in this embodiment is arranged in correspondence with the supporting device 100 for supporting the patient, wherein a plurality of accelerators 200 can be turned on individually or in combination to implement radiation therapy, and radiation therapy methods at more angles can be performed on the patient supporting device 100.

[0036] In this embodiment, the support device 100 may be a support bed or a support chair, as long as it can actually support the patient.

[0037] The plurality of accelerators 200 are mounted on a support frame, wherein the support frame is rotatable, so that when the support frame rotates, the individual accelerators 200 provide radiation from different angles. The plurality of accelerators 200 can be mounted on a plurality of mechanical arms, respectively. In an exemplary implementation, the plurality of mechanical arms operate and move independently, so that individual accelerators in the first plurality of accelerators provide radiation from different angles; the operation of the plurality of accelerators can be coordinated with a medical treatment plan; and the plurality of accelerators are all controlled by a control module 300.

[0038] The radiation system is an independent radiation module, which can adopt any one of the radiation modes, or a combination of any two or three radiation modes.

[0039] In one embodiment, multiple accelerators 200 are used to deliver doses from different orientations or angles. Delivery can be done simultaneously or sequentially; in one embodiment, simultaneous or substantially simultaneous means that multiple things exist or occur within a time of less than or equal to one second of each other. In one embodiment, simultaneous or substantially simultaneous means less than or equal to one millisecond. Multiple accelerators 200 can be implemented in various configurations. The number of accelerator systems and the differences in the angles at which the radiation beams are applied can vary. In one embodiment, a power supply unit can power multiple independent accelerator systems.

[0040] In this embodiment, the radiation system includes a combination of electronic flash therapy (FLASH) and ordinary X-ray radiotherapy, wherein:

[0041] Electron flash therapy (FLASH) is an emerging treatment technology that uses ultra-high dose rates to effectively kill cancer cells while protecting healthy tissues. The two elements of electron flash therapy (FLASH) are ultra-high dose rates and fractionated doses within an ultra-short time of no more than 0.3 seconds, which significantly reduces damage to healthy tissues.

[0042] Ordinary X-ray radiotherapy; Ordinary X-ray radiotherapy generally releases photons, that is, high-energy photon rays are used to kill cancer cells; it has wide adaptability and maturity of technical application, and is currently the preferred method for many cancer treatments; high-end photon radiotherapy equipment such as Cyberknife and Tomo have been launched one after another, achieving a more flexible treatment range, more precise motion tracking, clearer image guidance, and more precise dose carving.

[0043] Therefore, the use of FLASH and ordinary X-ray radiotherapy can not only solve the weakness of poor dose distribution in the target area, but also solve the disadvantage of excessive dose of normal tissues around the target area. It is a very practical radiotherapy technology. Compared with the use of FLASH or ordinary X-ray radiotherapy alone, the dose distribution in the target area is more uniform and the surrounding normal tissues are better protected; such as its use in radical surgery for breast cancer.

[0044] The radiation transfer method of a medical linear accelerator comprises the following steps:

[0045] Step 1: generating radiation at least partially simultaneously in a plurality of accelerators 200;

[0046] Step 2: Coordinate the movement of electron beam impacts on high intensity targets included in the plurality of accelerators 200; and transmit radiation from different orientations to target tissues in a patient;

[0047] Step 3: Select a suitable radiation system in cooperation with the control module according to the actual situation of the patient; in this embodiment, a combination of electronic flash therapy (FLASH) and ordinary X-ray radiotherapy is selected.

[0048] Embodiment 2:

[0049] In this embodiment, the radiation system includes a combination of electronic flash therapy (FLASH) and ordinary electronic radiotherapy, wherein:

[0050] Electron flash therapy (FLASH) is an emerging treatment technology that uses ultra-high dose rates to effectively kill cancer cells while protecting healthy tissues. The two elements of electron flash therapy (FLASH) are ultra-high dose rates and fractionated doses within an ultra-short time of no more than 0.3 seconds, which significantly reduces damage to healthy tissues.

[0051] Ordinary electron radiotherapy: Ordinary electron radiotherapy is a universal killing method that kills tumor cells and also damages normal cells around tumor tissue. Therefore, the efficacy of ordinary radiotherapy is worse than that of proton radiotherapy, and the side effects are higher than those of proton radiotherapy.

[0052] For elderly patients with eczematoid carcinoma, the tumor is relatively shallow, and the skin of the scrotum is more sensitive and less tolerant than the skin of other parts. According to clinical data and experience, if conventional radiotherapy is performed on the patient, the toxic and side effects will be relatively large. The patient's condition is more suitable for ultra-high dose rate radiotherapy.

[0053] Therefore, the combination of electron flash therapy (FLASH) and ordinary electron radiotherapy can reduce the toxic and side effects of the scrotal skin while ensuring the same therapeutic effect as conventional radiotherapy, which is beneficial to improving the patient's quality of life; and ordinary electron radiotherapy has a killing effect on tumor cells. Therefore, the combination of the two can achieve better results.

[0054] The radiation transfer method of a medical linear accelerator comprises the following steps:

[0055] Step 1: generating radiation at least partially simultaneously in a plurality of accelerators 200;

[0056] Step 2: Coordinate the movement of electron beam impacts on high intensity targets included in the plurality of accelerators 200; and transmit radiation from different orientations to target tissues in a patient;

[0057] Step 3: Select a suitable radiation system in cooperation with the control module according to the actual situation of the patient; in this embodiment, a combination of electronic flash therapy (FLASH) and ordinary electronic radiotherapy is selected.

[0058] For other contents in this embodiment, refer to Embodiment 1.

[0059] Embodiment 3:

[0060] In this embodiment, the radiation system includes a combination of electronic flash therapy (FLASH) and X-ray flash therapy (X-ray FLASH), wherein:

[0061] Electron flash therapy (FLASH) is an emerging treatment technology that uses ultra-high dose rates to effectively kill cancer cells while protecting healthy tissues. The two elements of electron flash therapy (FLASH) are ultra-high dose rates and fractionated doses within an ultra-short time of no more than 0.3 seconds, which significantly reduces damage to healthy tissues.

[0062] X-ray flash therapy (X-ray FLASH); X-ray flash therapy (X-ray FLASH) is mainly manifested in the characteristics of radiation physics and radiation biology. Protons are a positively charged, large mass, strong penetrating power, and cause little damage to normal tissues, especially the front, side and back of the tumor. Because of the fast speed during the penetration process, normal tissues absorb less. Proton therapy for tumors is a relatively effective treatment method with advantages. At the same time, the penumbra of protons is relatively small, and the scattering formed is less, so the dose in the tumor tissue is relatively large, and the characteristics of radiation physics can be used to effectively treat tumors.

[0063] The radiation transfer method of a medical linear accelerator comprises the following steps:

[0064] Step 1: generating radiation at least partially simultaneously in a plurality of accelerators 200;

[0065] Step 2: Coordinate the movement of electron beam impacts on high intensity targets included in the plurality of accelerators 200; and transmit radiation from different orientations to target tissues in a patient;

[0066] Step 3: Select a suitable radiation system in cooperation with the control module according to the actual situation of the patient; in this embodiment, a combination of electronic flash therapy (FLASH) and X-ray flash therapy (X-ray FLASH) is selected.

[0067] For other contents in this embodiment, refer to Embodiment 1.

[0068] Embodiment 4:

[0069] In this embodiment, the radiation system includes a combination of ordinary X-ray radiotherapy and X-ray flash therapy (X-ray FLASH), wherein:

[0070] Ordinary X-ray radiotherapy; Ordinary X-ray radiotherapy generally releases photons, that is, high-energy photon rays are used to kill cancer cells; it has wide adaptability and maturity of technical application, and is currently the preferred method for many cancer treatments; high-end photon radiotherapy equipment such as Cyberknife and Tomo have been launched one after another, achieving a more flexible treatment range, more precise motion tracking, clearer image guidance, and more precise dose carving.

[0071] X-ray flash therapy (X-ray FLASH); X-ray flash therapy (X-ray FLASH) is mainly manifested in the characteristics of radiation physics and radiation biology. Protons are a positively charged, large mass, strong penetrating power, and cause little damage to normal tissues, especially the front, side and back of the tumor. Because of the fast speed during the penetration process, normal tissues absorb less. Proton therapy for tumors is a relatively effective treatment method with advantages. At the same time, the penumbra of protons is relatively small, and the scattering formed is less, so the dose in the tumor tissue is relatively large, and the characteristics of radiation physics can be used to effectively treat tumors.

[0072] The radiation transfer method of a medical linear accelerator comprises the following steps:

[0073] Step 1: generating radiation at least partially simultaneously in a plurality of accelerators 200;

[0074] Step 2: Coordinate the movement of electron beam impacts on high intensity targets included in the plurality of accelerators 200; and transmit radiation from different orientations to target tissues in a patient;

[0075] Step 3: According to the actual situation of the patient, cooperate with the control module to select a suitable radiation system; in this embodiment, a combination of ordinary X-ray radiotherapy and X-ray flash therapy (X-ray FLASH) is selected.

[0076] For other contents in this embodiment, refer to Embodiment 1.

[0077] Embodiment 5:

[0078] In this embodiment, the radiation system includes a combination of ordinary electron radiotherapy and X-ray flash therapy (X-ray FLASH), wherein:

[0079] Ordinary electron radiotherapy: Ordinary electron radiotherapy is a universal killing method that kills tumor cells and also damages normal cells around tumor tissue. Therefore, the efficacy of ordinary radiotherapy is worse than that of proton radiotherapy, and the side effects are higher than those of proton radiotherapy.

[0080] X-ray flash therapy (X-ray FLASH); X-ray flash therapy (X-ray FLASH) is mainly manifested in the characteristics of radiation physics and radiation biology; protons are a positive charge with large mass and strong penetrating power, which causes little damage to normal tissues, especially the front, side and back of the tumor. Because of the fast speed during the penetration process, the normal tissue absorbs less. Proton therapy for tumors is a relatively effective treatment method with advantages. At the same time, the penumbra of protons is relatively small, and the scattering formed is less, so the dose in the tumor tissue is relatively large, and the characteristics of radiation physics can be used to effectively treat tumors.

[0081] The radiation transfer method of a medical linear accelerator comprises the following steps:

[0082] Step 1: generating radiation at least partially simultaneously in a plurality of accelerators 200;

[0083] Step 2: Coordinate the movement of electron beam impacts on high intensity targets included in the plurality of accelerators 200; and transmit radiation from different orientations to target tissues in a patient;

[0084] Step 3: Select a suitable radiation system in cooperation with the control module according to the actual situation of the patient; in this embodiment, a combination of ordinary electronic radiotherapy and X-ray flash therapy (X-ray FLASH) is selected.

[0085] For other contents in this embodiment, refer to Embodiment 1.

[0086] Embodiment 6:

[0087] In this embodiment, the radiation system includes a combination of electronic flash therapy (FLASH), ordinary X-ray radiotherapy and ordinary electronic radiotherapy, wherein:

[0088] Electron flash therapy (FLASH) is an emerging treatment technology that uses ultra-high dose rates to effectively kill cancer cells while protecting healthy tissues. The two elements of electron flash therapy (FLASH) are ultra-high dose rates and fractionated doses within an ultra-short time of no more than 0.3 seconds, which significantly reduces damage to healthy tissues.

[0089] Ordinary X-ray radiotherapy; Ordinary X-ray radiotherapy generally releases photons, that is, high-energy photon rays are used to kill cancer cells; it has wide adaptability and maturity of technical application, and is currently the preferred method for many cancer treatments; high-end photon radiotherapy equipment such as Cyberknife and Tomo have been launched one after another, achieving a more flexible treatment range, more precise motion tracking, clearer image guidance, and more precise dose carving.

[0090] Ordinary electron radiotherapy: Ordinary electron radiotherapy is a universal killing method that kills tumor cells and also damages normal cells around tumor tissue. Therefore, the efficacy of ordinary radiotherapy is worse than that of proton radiotherapy, and the side effects are higher than those of proton radiotherapy.

[0091] The radiation transfer method of a medical linear accelerator comprises the following steps:

[0092] Step 1: generating radiation at least partially simultaneously in a plurality of accelerators 200;

[0093] Step 2: Coordinate the movement of electron beam impacts on high intensity targets included in the plurality of accelerators 200; and transmit radiation from different orientations to target tissues in a patient;

[0094] Step 3: Select a suitable radiation system in cooperation with the control module according to the actual situation of the patient; in this embodiment, a combination of electronic flash therapy (FLASH), ordinary X-ray radiotherapy and ordinary electronic radiotherapy is selected.

[0095] For other contents in this embodiment, refer to Embodiment 1.

[0096] Embodiment 7:

[0097] In this embodiment, the radiation system includes a combination of electronic flash therapy (FLASH), ordinary X-ray radiotherapy and X-ray flash therapy (X-ray FLASH), wherein:

[0098] Electron flash therapy (FLASH) is an emerging treatment technology that uses ultra-high dose rates to effectively kill cancer cells while protecting healthy tissues. The two elements of electron flash therapy (FLASH) are ultra-high dose rates and fractionated doses within an ultra-short time of no more than 0.3 seconds, which significantly reduces damage to healthy tissues.

[0099] Ordinary X-ray radiotherapy; Ordinary X-ray radiotherapy generally releases photons, that is, high-energy photon rays are used to kill cancer cells; it has wide adaptability and maturity of technical application, and is currently the preferred method for many cancer treatments; high-end photon radiotherapy equipment such as Cyberknife and Tomo have been launched one after another, achieving a more flexible treatment range, more precise motion tracking, clearer image guidance, and more precise dose carving.

[0100] X-ray flash therapy (X-ray FLASH); X-ray flash therapy (X-ray FLASH) is mainly manifested in the characteristics of radiation physics and radiation biology. Protons are a positively charged, large mass, strong penetrating power, and cause little damage to normal tissues, especially the front, side and back of the tumor. Because of the fast speed during the penetration process, normal tissues absorb less. Proton therapy for tumors is a relatively effective treatment method with advantages. At the same time, the penumbra of protons is relatively small, and the scattering formed is less, so the dose in the tumor tissue is relatively large, and the characteristics of radiation physics can be used to effectively treat tumors.

[0101] The radiation transfer method of a medical linear accelerator comprises the following steps:

[0102] Step 1: generating radiation at least partially simultaneously in a plurality of accelerators 200;

[0103] Step 2: Coordinate the movement of electron beam impacts on high intensity targets included in the plurality of accelerators 200; and transmit radiation from different orientations to target tissues in a patient;

[0104] Step 3: Select a suitable radiation system in cooperation with the control module according to the actual situation of the patient; in this embodiment, a combination of electronic flash therapy (FLASH), ordinary X-ray radiotherapy and X-ray flash therapy (X-ray FLASH) is selected.

[0105] For other contents in this embodiment, refer to Embodiment 1.

[0106] Embodiment 8:

[0107] In this embodiment, the radiation system includes a combination of electronic flash therapy (FLASH), ordinary electronic radiotherapy and X-ray flash therapy (X-ray FLASH), wherein:

[0108] Electron flash therapy (FLASH) is an emerging treatment technology that uses ultra-high dose rates to effectively kill cancer cells while protecting healthy tissues. The two elements of electron flash therapy (FLASH) are ultra-high dose rates and fractionated doses within an ultra-short time of no more than 0.3 seconds, which significantly reduces damage to healthy tissues.

[0109] Ordinary electron radiotherapy: Ordinary electron radiotherapy is a universal killing method that kills tumor cells and also damages normal cells around tumor tissue. Therefore, the efficacy of ordinary radiotherapy is worse than that of proton radiotherapy, and the side effects are higher than those of proton radiotherapy.

[0110] X-ray flash therapy (X-ray FLASH); X-ray flash therapy (X-ray FLASH) is mainly manifested in the characteristics of radiation physics and radiation biology. Protons are a positively charged, large mass, strong penetrating power, and cause little damage to normal tissues, especially the front, side and back of the tumor. Because of the fast speed during the penetration process, normal tissues absorb less. Proton therapy for tumors is a relatively effective treatment method with advantages. At the same time, the penumbra of protons is relatively small, and the scattering formed is less, so the dose in the tumor tissue is relatively large, and the characteristics of radiation physics can be used to effectively treat tumors.

[0111] The radiation transfer method of a medical linear accelerator comprises the following steps:

[0112] Step 1: generating radiation at least partially simultaneously in a plurality of accelerators 200;

[0113] Step 2: Coordinate the movement of electron beam impacts on high intensity targets included in the plurality of accelerators 200; and transmit radiation from different orientations to target tissues in a patient;

[0114] Step 3: Select a suitable radiation system in cooperation with the control module according to the actual situation of the patient; in this embodiment, a combination of electronic flash therapy (FLASH), ordinary electronic radiotherapy and X-ray flash therapy (X-ray FLASH) is selected.

[0115] For other contents in this embodiment, refer to Embodiment 1.

[0116] Embodiment 9:

[0117] In this embodiment, the radiation system includes a combination of ordinary X-ray radiotherapy, ordinary electron radiotherapy and X-ray flash therapy (X-ray FLASH), wherein:

[0118] Ordinary X-ray radiotherapy; Ordinary X-ray radiotherapy generally releases photons, that is, high-energy photon rays are used to kill cancer cells; it has wide adaptability and maturity of technical application, and is currently the preferred method for many cancer treatments; high-end photon radiotherapy equipment such as Cyberknife and Tomo have been launched one after another, achieving a more flexible treatment range, more precise motion tracking, clearer image guidance, and more precise dose carving.

[0119] Ordinary electron radiotherapy: Ordinary electron radiotherapy is a universal killing method that kills tumor cells and also damages normal cells around tumor tissue. Therefore, the efficacy of ordinary radiotherapy is worse than that of proton radiotherapy, and the side effects are higher than those of proton radiotherapy.

[0120] X-ray flash therapy (X-ray FLASH); X-ray flash therapy (X-ray FLASH) is mainly manifested in the characteristics of radiation physics and radiation biology. Protons are a positively charged, large mass, strong penetrating power, and cause little damage to normal tissues, especially the front, side and back of the tumor. Because of the fast speed during the penetration process, normal tissues absorb less. Proton therapy for tumors is a relatively effective treatment method with advantages. At the same time, the penumbra of protons is relatively small, and the scattering formed is less, so the dose in the tumor tissue is relatively large, and the characteristics of radiation physics can be used to effectively treat tumors.

[0121] The radiation transfer method of a medical linear accelerator comprises the following steps:

[0122] Step 1: generating radiation at least partially simultaneously in a plurality of accelerators 200;

[0123] Step 2: Coordinate the movement of electron beam impacts on high intensity targets included in the plurality of accelerators 200; and transmit radiation from different orientations to target tissues in a patient;

[0124] Step 3: Select a suitable radiation system in cooperation with the control module according to the actual situation of the patient; in this embodiment, a combination of ordinary X-ray radiotherapy, ordinary electronic radiotherapy and X-ray flash therapy (X-ray FLASH) is selected.

[0125] For other contents in this embodiment, refer to Embodiment 1.

[0126] Embodiment 10:

[0127] In this embodiment, the radiation system includes electronic flash therapy (FLASH), ordinary X-ray radiotherapy, ordinary electronic radiotherapy and X-ray flash therapy (X-ray FLASH), wherein:

[0128] Electron flash therapy (FLASH) is an emerging treatment technology that uses ultra-high dose rates to effectively kill cancer cells while protecting healthy tissues. The two elements of electron flash therapy (FLASH) are ultra-high dose rates and fractionated doses within an ultra-short time of no more than 0.3 seconds, which significantly reduces damage to healthy tissues.

[0129] Ordinary X-ray radiotherapy; Ordinary X-ray radiotherapy generally releases photons, that is, high-energy photon rays are used to kill cancer cells; it has wide adaptability and maturity of technical application, and is currently the preferred method for many cancer treatments; high-end photon radiotherapy equipment such as Cyberknife and Tomo have been launched one after another, achieving a more flexible treatment range, more precise motion tracking, clearer image guidance, and more precise dose carving.

[0130] Ordinary electron radiotherapy: Ordinary electron radiotherapy is a universal killing method that kills tumor cells and also damages normal cells around tumor tissue. Therefore, the efficacy of ordinary radiotherapy is worse than that of proton radiotherapy, and the side effects are higher than those of proton radiotherapy.

[0131] X-ray flash therapy (X-ray FLASH); X-ray flash therapy (X-ray FLASH) is mainly manifested in the characteristics of radiation physics and radiation biology. Protons are a positively charged, large mass, strong penetrating power, and cause little damage to normal tissues, especially the front, side and back of the tumor. Because of the fast speed during the penetration process, normal tissues absorb less. Proton therapy for tumors is a relatively effective treatment method with advantages. At the same time, the penumbra of protons is relatively small, and the scattering formed is less, so the dose in the tumor tissue is relatively large, and the characteristics of radiation physics can be used to effectively treat tumors.

[0132] The radiation transfer method of a medical linear accelerator comprises the following steps:

[0133] Step 1: generating radiation at least partially simultaneously in a plurality of accelerators 200;

[0134] Step 2: Coordinate the movement of electron beam impacts on high intensity targets included in the plurality of accelerators 200; and transmit radiation from different orientations to target tissues in a patient;

[0135] Step 3: Select a suitable radiation system in cooperation with the control module according to the actual situation of the patient; in this embodiment, electronic flash therapy (FLASH), ordinary X-ray radiotherapy, or a combination of ordinary electronic radiotherapy and X-ray flash therapy (X-ray FLASH) are selected.

[0136] For other contents in this embodiment, refer to Embodiment 1.

[0137] The above description of the disclosed embodiments enables one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention; therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

[0138] Although this article makes use of the following terms more frequently: support device 100, accelerator 200, control module 300, etc., the possibility of using other terms is not excluded; these terms are used only to more conveniently describe and explain the essence of the present invention; interpreting them as any additional limitations is contrary to the spirit of the present invention.

Claims

1. A radiation system of a medical linear accelerator, characterized in that: include A support device (100), a plurality of accelerators (200) and a control module (300), wherein: The support device (100) can perform multi-dimensional movements and is used to carry a patient; The accelerator (200) is used to generate a radiation beam to irradiate the patient; The control module (300) is used to control the plurality of accelerators (200) and the supporting device (100); Through the multi-dimensional movement of the support device (100), the accelerator (200) located on the patient support device (100) performs non-coplanar radiotherapy on the target treatment area of ​​the patient. Intensity modulated radiation therapy is achieved by controlling a plurality of accelerators (200) to be turned on individually or in combination, wherein a plurality of radiation beams from the accelerators (200) are configured to be transmitted in different directions.

2. The radiation system of the medical linear accelerator according to claim 1, characterized in that: The plurality of accelerators (200) are mounted on a support frame.

3. The radiation system of the medical linear accelerator according to claim 1, characterized in that: The support frame is rotatable so that when the support frame rotates, the individual accelerators (200) provide radiation from different angles.

4. The radiation system of the medical linear accelerator according to claim 1, characterized in that: The radiation systems include electron flash therapy (FLASH), ordinary X-ray radiotherapy, ordinary electron radiotherapy, and X-ray flash therapy (X-ray FLASH).

5. The radiation system of the medical linear accelerator according to claim 4, characterized in that: The radiation system is an independent radiation module, which can adopt any one of the radiation modes, or a combination of any two or three.

6. The radiation system of the medical linear accelerator according to claim 4, characterized in that: The radiation system adopts four combinations: electronic flash therapy (FLASH), ordinary X-ray radiotherapy, ordinary electronic radiotherapy, and X-ray flash therapy (X-ray FLASH).

7. A radiation transfer method for a medical linear accelerator, comprising the following steps: Step 1: generating radiation at least partially simultaneously in a plurality of accelerators (200); Step 2: Coordinating the movement of electron beam impacts on high intensity targets included in the plurality of accelerators (200); and delivering radiation from different orientations to target tissue in a patient; Step 3: Select a suitable radiation system based on the patient's actual situation and in coordination with the control module.

8. The radiation transfer method of a medical linear accelerator according to claim 7, characterized in that: The radiation systems include electron flash therapy (FLASH), ordinary X-ray radiotherapy, ordinary electron radiotherapy, and X-ray flash therapy (X-ray FLASH).

9. The radiation transfer method of a medical linear accelerator according to claim 8, characterized in that: The radiation system is an independent radiation module, which can adopt any one of the radiation modes, or a combination of any two or three.

10. The radiation transfer method of a medical linear accelerator according to claim 8, characterized in that: The radiation system adopts four combinations.

Images