Medical intermediate purification processing device and purification method

Abstract

The invention discloses a medical intermediate purification processing device and a purification method, and belongs to the technical field of raw material medicine purification, the medical intermediate purification processing device comprises a body, an evaporation bin, a heating bin and a liquid medicine bin, a heating rod is arranged in the heating bin, steam generated in the heating bin heats the evaporation bin from the bottom of the evaporation bin, and a medicine supply pump is connected to the liquid medicine bin; the inlet end of the medicine supply pump is communicated with the liquid medicine bin, the outlet end of the medicine supply pump is communicated with the evaporation bin through one or more medicine supply pipes, and the medicine supply pipes penetrate through the heating bin. Medical intermediates in the evaporation bin can be indirectly heated, the heating temperature is uniform, and excessive heating of liquid is reduced; steam in the hot bin is used for heating liquid conveyed in the medicine supply pipe, and compared with overall heating of the evaporation pan, the liquid is conveyed and heated in a dispersed mode, and the heating and purifying efficiency is high; when the driving shaft rotates, the stirring paddle can stir water in the heating bin, the heating efficiency is improved, and the functions of liquid conveying and heating bin stirring can be completed by arranging a single motor.

Description

Technical Field

[0001] The invention belongs to the technical field of raw material drug purification, and specifically relates to a pharmaceutical intermediate purification processing device and a purification method. Background Art

[0002] The so-called pharmaceutical intermediates are some API raw materials or API products used in the pharmaceutical synthesis process.

[0003] In order to ensure the production quality of drugs, pharmaceutical intermediates are purified many times. There are many methods for purifying pharmaceutical intermediates, among which evaporation and concentration is a common purification method. During evaporation and concentration purification, the intermediate solution is generally directly added to the refining kettle for purification. During purification, many intermediates are gathered together. Due to uneven heating, low heating efficiency and slow evaporation rate, the purification effect is affected. Therefore, a purification processing equipment for pharmaceutical intermediates and an intermediate purification method are needed to improve the above problems. Summary of the invention

[0004] In view of the above problems existing in the prior art, the technical problem to be solved by the present invention is to provide a pharmaceutical intermediate purification processing device and a purification method to improve the purification efficiency.

[0005] Technical solution: In order to solve the above technical problems, the technical solution adopted by the present invention is as follows:

[0006] A pharmaceutical intermediate purification and processing device comprises a body, an evaporation bin arranged in the body, a heating bin arranged below the evaporation bin and used to contain water, and a liquid medicine bin arranged below the heating bin, wherein a heating rod is arranged in the heating bin, and the steam generated in the heating bin heats the evaporation bin from the bottom of the evaporation bin, and a drug supply pump is connected to the liquid medicine bin, wherein an inlet end of the drug supply pump is communicated with the liquid medicine bin, and an outlet end of the drug supply pump is communicated with the evaporation bin through one or more drug supply pipes, and the drug supply pipes run through the heating bin.

[0007] Preferably, the medicine supply tube is outer-coated with a hollow steam tube, the bottom of the heating chamber is connected to an exhaust chamber, the upper end of the hollow steam tube is located above the water surface of the heating chamber, the lower end of the hollow steam tube is connected to the exhaust chamber, and the exhaust chamber is connected to a steam exhaust pipe.

[0008] Preferably, a bottom plate is provided at the bottom of the heating chamber, a hollow cavity connected to the drug supply pipe is provided in the bottom plate, and an outlet end of the drug supply pump is connected to the hollow cavity.

[0009] Preferably, the drug supply pump includes a shell connected to the base plate, a drive shaft penetrating the shell along an extension direction of the shell, a spiral blade arranged on the drive shaft, and a drive motor connected to the drive shaft.

[0010] Preferably, the driving motor is connected to the outer top wall of the main body, the driving shaft passes through the evaporation chamber and the heating chamber, and a stirring paddle is provided on the driving shaft, and the stirring paddle is located in the heating chamber.

[0011] Preferably, the outer wall of the medicine supply tube is connected with heat-conducting fins.

[0012] Preferably, the main body is provided with a drug adding pipe connected to the drug liquid bin, a water injection pipe connected to the heating bin, and an evaporation port and a recovery drain pipe connected to the evaporation bin.

[0013] Preferably, a liquid level sensor is provided in the medicine liquid tank, and the main body is provided with a controller electrically connected to the liquid level sensor, and a display screen and a buzzer electrically connected to the controller.

[0014] The present invention also provides a method for purifying a pharmaceutical intermediate, using the above-mentioned pharmaceutical intermediate purification processing device, comprising the following steps:

[0015] Step 1: The drug supply pump works to supply the liquid of the pharmaceutical intermediate in the drug liquid tank upward through the heating tank through the drug supply pipe and then to the evaporation tank;

[0016] Step 2: The heating rod works to heat the water in the heating chamber to boil and generate steam, and the steam heats the evaporation chamber above the heating chamber at the top of the heating chamber;

[0017] Step 3: The steam enters the exhaust chamber through the steam hollow tube, heats the outer wall of the drug supply tube while passing through the steam hollow tube, thereby heating the pharmaceutical intermediate in the drug supply tube, and the steam in the exhaust chamber is discharged from the steam exhaust pipe.

[0018] Beneficial effects: Compared with the prior art, the present invention has the following advantages:

[0019] 1. By setting up the evaporation chamber and the heating chamber, the heating rod makes the water in the heating chamber boil, which can indirectly heat the pharmaceutical intermediates in the evaporation chamber, and the heating temperature is uniform, which prevents the heating rod from directly contacting the pharmaceutical intermediate liquid and reduces excessive heating of the liquid;

[0020] 2. The drug supply pump and the drug supply pipe are used to disperse and transport the pharmaceutical intermediate liquid in the drug liquid warehouse upward to the evaporation warehouse. A steam hollow pipe is arranged on the outer surface of the drug supply pipe, and the liquid transported in the drug supply pipe is heated by the steam in the hot warehouse. Compared with the overall heating of the evaporator, the present invention disperses and transports the liquid and disperses the heating, and the heating and purification efficiency is high;

[0021] 3. The driving shaft of the medicine supply pump passes through the heating chamber. A stirring paddle connected to the driving shaft is provided in the heating chamber. When the driving shaft rotates, the stirring paddle can stir the water in the heating chamber to improve the heating efficiency. A single motor can complete the functions of liquid delivery and heating chamber stirring. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a schematic diagram of the internal structure of an embodiment of the present invention;

[0023] Figure 2 It is a schematic diagram of the structure of the evaporation chamber 2 and the heating chamber of the embodiment;

[0024] Figure 3 2. It is a schematic diagram of the internal structure of the heating chamber of the embodiment;

[0025] Figure 4 2. It is a schematic cross-sectional view of a medicine supply pipe and a steam hollow pipe in an embodiment;

[0026] Figure 5 It is a schematic diagram of the external structure of an embodiment of the present invention. DETAILED DESCRIPTION

[0027] The present invention is further illustrated below in conjunction with specific examples. The examples are implemented based on the technical solutions of the present invention. It should be understood that these examples are only used to illustrate the present invention and are not used to limit the scope of the present invention.

[0028] like Figure 1 As shown, a pharmaceutical intermediate purification processing device includes a body 1, an evaporation chamber 2, a heating chamber 3, a liquid medicine chamber 4, a drug supply pump 5 and an exhaust chamber 7. The body 1 is a rectangular box, and the evaporation chamber 2, the heating chamber 3, the liquid medicine chamber 4, the drug supply pump 5 and the exhaust chamber 7 are all arranged in the body 1. The evaporation chamber 2 is arranged at the top of the body 1, and the heating chamber 3 is arranged below the evaporation chamber 2. The top wall of the heating chamber 3 is connected to the bottom wall of the evaporation chamber 2. The heating chamber 3 is used to contain water. The exhaust chamber 7 is arranged below the heating chamber 3, and the liquid medicine chamber 4 is arranged below the exhaust chamber 7. A drug adding pipe 41 connected to the liquid medicine chamber 4 is provided on the side wall of the body 1, and the pharmaceutical intermediate liquid is injected into the liquid medicine chamber 4 through the drug adding pipe 41. A water injection pipe 33 connected to the heating chamber 3 is provided on the top wall of the body 1, and water is injected into the heating chamber 3 through the water injection pipe 33. An evaporation port 21 connected to the evaporation bin 2 is provided on the top wall of the main body 1, and the evaporated gas in the evaporation bin 2 is collected from the evaporation port 21. A recovery drain pipe 22 connected to the evaporation bin 2 is also provided on the top side wall of the main body 1. A drain valve is provided on the recovery drain pipe 22, which is used to discharge the residual liquid in the evaporation bin 2 when opened.

[0029] like Figure 1 , Figure 2 and Figure 3As shown, a plurality of heating rods 31 are arranged in the heating chamber 3, and a bottom plate 32 is arranged at the bottom of the heating chamber 3. The heating rods 31 adopt existing electric heating rods, and a plurality of heating rods 31 are distributed in a circular array on the bottom plate 32. A medicine supply pump 5 is connected to the liquid medicine chamber 4, and the medicine supply pump 5 adopts a spiral pump. The medicine supply pump 5 includes a shell 51, a drive shaft 52, a spiral blade 53 and a drive motor 54. The shell 51 is arranged in the up-down direction, and the shell 51 passes downward through the exhaust chamber 7 to reach the liquid medicine chamber 4, and its lower end is connected with the liquid medicine chamber 4. The lower end of the shell 51 is the inlet end of the medicine supply pump 5, and the upper end of the shell 51 is connected to the bottom plate 32. The upper end of the shell 51 is the outlet end of the medicine supply pump 5. A hollow cavity 321 connected to the upper outlet of the shell 51 is arranged in the bottom plate 32, and the drive shaft 52 penetrates the shell 51 along the extension direction of the shell 51. The spiral blade 53 is located in the shell 51 and connected to the outer wall of the drive shaft 52. The drive shaft 52 extends upward and penetrates the heating chamber 3. and the evaporation bin 2, the driving motor 54 is arranged in the middle position of the outer top wall of the main body 1, the driving shaft 52 is connected to the driving motor 54, and the driving motor 54 drives the driving shaft 52 to rotate when working, thereby driving the spiral blade 53 to rotate, and when the spiral blade 53 rotates, the pharmaceutical intermediate liquid in the medicine liquid bin 4 is transported upward to the hollow cavity 321, and a plurality of drug supply pipes 61 connected to the hollow cavity 321 are provided on the bottom plate 32, and the plurality of drug supply pipes 61 are distributed in a ring array on the bottom plate 32 and are provided with three circles inside and outside, and the plurality of drug supply pipes 61 extend upward through the top wall of the heating bin 3, and the upper end of the drug supply pipe 61 is located in the evaporation bin 2, and under the action of the drug supply pump 5, the liquid continues to move upward from the hollow cavity 321 along the drug supply pipe 61 to reach the evaporation bin 2.

[0030] like Figure 1 , Figure 2 , Figure 3 and Figure 4 As shown, a steam hollow tube 62 is provided on the outer sleeve of the medicine supply pipe 61, the upper end of the steam hollow tube 62 is located above the water surface of the heating chamber 3, and the lower end of the steam hollow tube 62 is connected to the exhaust chamber 7. When the multiple heating rods 31 are working, they heat the water in the heating chamber 3, and the generated steam heats the pharmaceutical intermediate liquid in the evaporation chamber 2 at the top of the heating chamber 3. The steam enters the exhaust chamber 7 downward from the gap between the steam hollow tube 62 and the medicine supply pipe 61, and a steam exhaust pipe 71 is connected to the side wall of the exhaust chamber 7, and the steam is discharged from the steam exhaust pipe 71. The outer wall of the medicine supply pipe 61 is connected to a plurality of heat-conducting fins 611, and the plurality of heat-conducting fins 611 are distributed in a ring array on the outer circumferential wall of the medicine supply pipe 61. The heat-conducting fins 611 can improve the heat exchange effect between the steam and the medicine supply pipe 61, and improve the heating effect of the liquid in the medicine supply pipe 61.

[0031] like Figure 1 and Figure 2As shown, a plurality of stirring paddles 521 are provided on the driving shaft 52, and the stirring paddles 521 are located in the heating chamber 3. Six stirring paddles 521 form a group, and a plurality of groups of stirring paddles 521 are arranged up and down on the driving shaft 52. When the driving shaft 52 rotates, the stirring paddles 521 can stir the water in the heating chamber 3 to heat the water evenly and improve the heating efficiency.

[0032] like Figure 1 and Figure 5 As shown, a liquid level sensor 42 is provided in the medicine liquid tank 4, and the liquid level sensor 42 adopts an existing liquid level meter. A controller (not shown in the figure) electrically connected to the liquid level sensor 42 is provided on the body 1, and the controller adopts an existing ARM single-chip controller. A display screen 11 and a buzzer 12 are provided on the side wall of the body 1, and the display screen 11 and the buzzer 12 are both electrically connected to the controller. The liquid level sensor 42 is used to measure the liquid level in the medicine liquid tank 4 and send the data to the controller. The display screen 11 displays the liquid level. When the liquid level is lower than a predetermined value, the buzzer 12 sounds an alarm. A liquid level observation window is also provided on the side wall of the medicine liquid tank 4, which is convenient for manual direct observation of the liquid level in the medicine liquid tank 4.

[0033] This embodiment also provides a method for purifying a pharmaceutical intermediate, using the above-mentioned pharmaceutical intermediate purification processing device, comprising the following steps:

[0034] Step 1: The drug supply pump 5 starts working, and the driving motor 54 drives the spiral blade 53 to rotate slowly, so that the liquid of the pharmaceutical intermediate in the drug liquid chamber 4 passes upward through the heating chamber 3 through the drug supply pipe 61 and is supplied to the evaporation chamber 2.

[0035] Step 2, the heating rod 31 works to heat the water in the heating chamber 3 to boil and generate steam, and the steam heats the evaporation chamber 2 above the top of the heating chamber 3; when the driving motor 54 works, it drives the stirring paddle 521 to work, thereby improving the heating efficiency.

[0036] Step 3, the steam enters the exhaust bin 7 through the steam hollow tube 62, and heats the outer wall of the drug supply tube 61 while passing through the steam hollow tube 62, thereby heating the pharmaceutical intermediate in the drug supply tube 61. The pharmaceutical intermediate has been heated before entering the evaporation bin 2. The steam in the exhaust bin 7 exchanges heat with the shell 51 in the exhaust bin 7, heating the pharmaceutical intermediate transported in the shell 51, and the steam is finally discharged from the steam exhaust pipe 71.

[0037] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A pharmaceutical intermediate purification and processing device, characterized in that: The invention comprises a body (1), an evaporation chamber (2) arranged in the body (1), a heating chamber (3) arranged below the evaporation chamber (2) and used for containing water, and a liquid medicine chamber (4) arranged below the heating chamber (3); a heating rod (31) is arranged in the heating chamber (3); the steam generated in the heating chamber (3) heats the evaporation chamber (2) from the bottom of the evaporation chamber (2); a medicine supply pump (5) is connected to the liquid medicine chamber (4); the inlet end of the medicine supply pump (5) is connected to the liquid medicine chamber (4); the outlet end of the medicine supply pump (5) is connected to the evaporation chamber (2) through one or more medicine supply pipes (61); and the medicine supply pipe (61) runs through the heating chamber (3).

2. The pharmaceutical intermediate purification processing device according to claim 1, characterized in that: The medicine supply pipe (61) is provided with a steam hollow pipe (62) on its outer sleeve, the bottom of the heating chamber (3) is connected to an exhaust chamber (7), the upper end of the steam hollow pipe (62) is located above the water surface of the heating chamber (3), the lower end of the steam hollow pipe (62) is connected to the exhaust chamber (7), and the exhaust chamber (7) is connected to a steam exhaust pipe (71).

3. The pharmaceutical intermediate purification processing device according to claim 2, characterized in that: The bottom of the heating chamber (3) is provided with a bottom plate (32), and a hollow cavity (321) communicating with the medicine supply pipe (61) is provided in the bottom plate (32), and the outlet end of the medicine supply pump (5) is communicated with the hollow cavity (321).

4. The pharmaceutical intermediate purification processing device according to claim 3, characterized in that: The drug supply pump (5) comprises a shell (51) connected to the base plate (32), a drive shaft (52) penetrating the shell (51) along the extension direction of the shell (51), a spiral blade (53) arranged on the drive shaft (52), and a drive motor (54) connected to the drive shaft (52).

5. The pharmaceutical intermediate purification processing device according to claim 4, characterized in that: The driving motor (54) is connected to the outer top wall of the body (1); the driving shaft (52) passes through the evaporation chamber (2) and the heating chamber (3); a stirring paddle (521) is provided on the driving shaft (52); and the stirring paddle (521) is located in the heating chamber (3).

6. The pharmaceutical intermediate purification processing device according to claim 2, characterized in that: The outer wall of the medicine supply pipe (61) is connected with a heat-conducting fin (611).

7. The pharmaceutical intermediate purification processing device according to claim 1, characterized in that: The body (1) is provided with a drug adding pipe (41) connected to the drug liquid bin (4), a water injection pipe (33) connected to the heating bin (3), and an evaporation port (21) and a recovery drain pipe (22) connected to the evaporation bin (2).

8. The pharmaceutical intermediate purification processing device according to claim 1, characterized in that: A liquid level sensor (42) is provided in the liquid medicine tank (4), and the body (1) is provided with a controller electrically connected to the liquid level sensor (42) and a display screen (11) and a buzzer (12) electrically connected to the controller.

9. A method for purifying a pharmaceutical intermediate, using the pharmaceutical intermediate purification processing device according to any one of claims 2 to 8, characterized in that: The following steps are involved: Step 1: The drug supply pump (5) operates to supply the liquid of the pharmaceutical intermediate in the drug liquid chamber (4) through the drug supply pipe (61) upward through the heating chamber (3) and then to the evaporation chamber (2); Step 2, the heating rod (31) works to heat the water in the heating chamber (3) to boil and generate steam, and the steam heats the evaporation chamber (2) above the top of the heating chamber (3); Step 3: The steam enters the exhaust chamber (7) through the steam hollow tube (62), heats the outer wall of the drug supply tube (61) while passing through the steam hollow tube (62), thereby heating the pharmaceutical intermediate in the drug supply tube (61), and the steam in the exhaust chamber (7) is discharged from the steam discharge pipe (71).

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