Blood potassium detection data correction method and system

Abstract

The invention relates to the field of data processing, in particular to a blood potassium detection data correction method and system. The method comprises the following steps: measuring the reflectivity of different wavelengths by adopting a plurality of test strips with known concentrations, and constructing a triple consisting of the wavelengths, the reflectivity and the concentrations; performing curve fitting on the reflectivity and the concentration in the triad with the same wavelength; irradiating the to-be-tested paper strip with light with different wavelengths to obtain the reflectivity corresponding to each wavelength, and determining the blood potassium concentration corresponding to the reflectivity of each wavelength of the to-be-tested paper strip from the fitted curve; and for each wavelength, finding out two triads which are the same as the wavelength of the to-be-tested paper strip and have the closest reflectivity, calculating the reflectivity of the to-be-tested paper strip and the distance between the reflectivity in the two triads with the closest reflectivity, and determining the credibility of the blood potassium concentration of the to-be-tested paper strip based on the distance, and calculating the corrected blood potassium concentration by adopting the credibility of the blood potassium concentration. According to the method, the accuracy of blood potassium detection data is improved by reducing errors during standard curve fitting.

Description

Technical Field

[0001] The present invention relates to the field of data processing, and in particular to a method and system for correcting blood potassium detection data. Background Art

[0002] Blood potassium level testing plays a great role in the diagnosis and treatment of cardiovascular, renal and endocrine system diseases. Fluctuations in blood potassium concentration directly affect the health of patients. The normal blood potassium range is usually 3.5-5.0 mmol / L, and high or low blood potassium values ​​may bring serious health risks. Hyperkalemia increases the risk of arrhythmias and even cardiac arrest, while hypokalemia can lead to a series of problems such as muscle weakness and dyspnea. Blood potassium testing can not only help doctors develop reasonable treatment plans, but also provide patients with necessary condition monitoring in intensive care. In clinical practice, blood gas analyzers and dry biochemical analyzers are mainly used to measure blood potassium levels. The blood gas analyzer uses an ion-selective electrode method, which can directly measure the potential changes of potassium ions, thereby obtaining high-precision blood potassium concentration data, but the blood gas analyzer is expensive, has high maintenance requirements, and is complex to operate, requiring professionals to calibrate and operate. The dry biochemical analyzer mainly uses reflectance photometry or colorimetry to calculate potassium ion concentration by utilizing the color reaction between samples and specific reagents. It is highly portable and easy to operate. Even non-professionals in primary hospitals can operate it. It is suitable for use in environments with relatively simple conditions or where rapid screening is required.

[0003] Although dry biochemical analyzers are portable, easy to operate, and do not require the use of liquid reagents, their detection accuracy is usually lower than that of blood gas analyzers, and their data accuracy is poor. In addition, they use the reflectivity of the test strip to determine the blood potassium content from the standard curve, but the standard curve itself is established based on the test strip with known blood potassium content. The standard curve itself has errors. If the standard curve itself has errors, no matter how the reflectivity is reduced or corrected, there will be errors. Summary of the invention

[0004] In view of the problem that the accuracy of blood potassium content data analyzed by a dry biochemical analyzer is poor, a method for correcting blood potassium detection data is provided in a first aspect of the present invention. The method comprises: Using multiple test strips with known concentrations to measure the reflectance at different wavelengths, constructing a triplet of wavelength, reflectance and concentration; performing curve fitting on the reflectance and concentration in the triplet of the same wavelength; Using light of different wavelengths to illuminate the test paper strip to obtain the reflectance corresponding to each wavelength, and determining the blood potassium concentration corresponding to the reflectance of each wavelength of the test paper strip from the fitting curve; For each wavelength, find two triplets with the same wavelength as the test strip and the closest reflectance, calculate the distance between the reflectance of the test strip and the reflectance in the two triplets with the closest reflectance, determine the credibility of the blood potassium concentration of the test strip based on the distance, and use the credibility of the blood potassium concentration to calculate the corrected blood potassium concentration.

[0005] Preferably, the curve fitting of the reflectivity and concentration in the triplet of the same wavelength is specifically as follows: For a set of triples consisting of triplets with the same wavelength, the reflectivity in the set is taken as the independent variable, the concentration in the set is taken as the dependent variable, and a curve corresponding to the wavelength is obtained by curve fitting for each set of triples; Using reflectances of triplets in the triplet set to divide the curve into a plurality of regions, and numbering the regions; Extracting all regions with the same number at all wavelengths to obtain a region set with the same number, dividing each region in the region set into the same number of sub-regions according to the reflectivity, and calculating the average concentration value of the endpoint reflectivity of the sub-regions with the same number on the curve; Inserting the average value of the concentration values ​​corresponding to the sub-region endpoint reflectance at the sub-region endpoint reflectance of each region in the region set; Curve fits were made for reflectance and concentration at each wavelength based on the interpolated values ​​and triplets in the region.

[0006] Preferably, the step of evenly dividing each region in the region set into the same number of sub-regions according to reflectivity is specifically as follows: Obtaining a ratio of the width of each region in the region set, and determining a moving step length of each region according to the ratio; Starting from the starting point of each area, each time the moving step is moved to obtain a value on the curve, and calculating the coefficient of variation of the values ​​on the curves of different areas in the area set when the same number of steps are moved; Determining the number of sub-intervals based on the average value of the coefficient of variation; Each region in the region set is divided into sub-intervals of the number of sub-intervals.

[0007] Preferably, the reliability of determining the blood potassium concentration of the test paper strip based on the distance is specifically: Calculate the distance between the reflectivity of the paper strip to be tested and the reflectivity in the closest triplet and use it as the closest distance, and calculate the distance between the reflectivity of the paper strip to be tested and the reflectivity in the second closest triplet and use it as the second closest distance; The sum of the closest distance and the second closest distance is calculated, and the ratio of the second closest distance to the sum is used as the reliability of the blood potassium concentration.

[0008] Preferably, the corrected blood potassium concentration is obtained by using the credibility calculation of the blood potassium concentration, specifically: The blood potassium concentration is weighted and summed using the credibility, and the ratio of the weighted summation result and the sum of the credibility is used as the corrected blood potassium concentration.

[0009] In a second aspect of the present invention, a blood potassium detection data correction system is provided, the system comprising: A standard curve construction module is used to measure the reflectance of different wavelengths using multiple test strips of known concentrations to construct a triple consisting of wavelength, reflectance and concentration; and to perform curve fitting on the reflectance and concentration in the triple of the same wavelength; The blood potassium concentration acquisition module is used to irradiate the test paper strip with light of different wavelengths to obtain the reflectivity corresponding to each wavelength, and determine the blood potassium concentration corresponding to the reflectivity of each wavelength of the test paper strip from the fitting curve; The data correction module is used to find, for each wavelength, two triplets with the same wavelength as the paper strip to be tested and the closest reflectance, calculate the distance between the reflectance of the paper strip to be tested and the reflectance in the two triplets with the closest reflectance, determine the credibility of the blood potassium concentration of the paper strip to be tested based on the distance, and calculate the corrected blood potassium concentration using the credibility of the blood potassium concentration.

[0010] Preferably, the curve fitting of the reflectivity and concentration in the triplet of the same wavelength is specifically as follows: For a set of triples consisting of triplets with the same wavelength, the reflectivity in the set is taken as the independent variable, the concentration in the set is taken as the dependent variable, and a curve corresponding to the wavelength is obtained by curve fitting for each set of triples; Using reflectances of triplets in the triplet set to divide the curve into a plurality of regions, and numbering the regions; Extracting all regions with the same number at all wavelengths to obtain a region set with the same number, dividing each region in the region set into the same number of sub-regions according to the reflectivity, and calculating the average concentration value of the endpoint reflectivity of the sub-regions with the same number on the curve; Inserting the average value of the concentration values ​​corresponding to the sub-region endpoint reflectance at the sub-region endpoint reflectance of each region in the region set; Curve fits were made for reflectance and concentration at each wavelength based on the interpolated values ​​and triplets in the region.

[0011] Preferably, the step of evenly dividing each region in the region set into the same number of sub-regions according to reflectivity is specifically as follows: Obtaining a ratio of the width of each region in the region set, and determining a moving step length of each region according to the ratio; Starting from the starting point of each area, each time the moving step is moved to obtain a value on the curve, and calculating the coefficient of variation of the values ​​on the curves of different areas in the area set when the same number of steps are moved; Determining the number of sub-intervals based on the average value of the coefficient of variation; Each region in the region set is divided into sub-intervals of the number of sub-intervals.

[0012] Preferably, the reliability of determining the blood potassium concentration of the test paper strip based on the distance is specifically: Calculate the distance between the reflectivity of the paper strip to be tested and the reflectivity in the closest triplet and use it as the closest distance, and calculate the distance between the reflectivity of the paper strip to be tested and the reflectivity in the second closest triplet and use it as the second closest distance; The sum of the closest distance and the second closest distance is calculated, and the ratio of the second closest distance to the sum is used as the reliability of the blood potassium concentration.

[0013] Preferably, the corrected blood potassium concentration is obtained by using the credibility calculation of the blood potassium concentration, specifically: The blood potassium concentration is weighted and summed using the credibility, and the ratio of the weighted summation result and the sum of the credibility is used as the corrected blood potassium concentration.

[0014] The present invention improves the standard curve for measuring blood potassium by reflectance photometry. In establishing the standard curve, the curve of each wavelength is refitted according to the curves of different wavelengths, so as to reduce the error introduced in establishing the standard curve. In addition, when calculating the blood potassium concentration, the credibility of the blood potassium concentration is determined according to the distance from the reflectance of the test strip of known concentration, and then the blood potassium concentration corresponding to different wavelengths and the credibility are calculated to obtain the corrected blood potassium concentration. The present invention not only reduces the error of the standard curve, but also recalculates the blood potassium concentration according to the credibility of the blood potassium concentration measured at multiple wavelengths to obtain the corrected blood potassium concentration, thereby effectively reducing the error of the dry analyzer, i.e., the reflectance photometry method, in measuring blood potassium. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 This is a flow chart of Embodiment 1; Figure 2 is a schematic diagram of curve fitting; Figure 3 is another flow chart of curve fitting; Figure 4 A schematic diagram of dividing a standard curve of one wavelength into regions; Figure 5 Schematic diagram of sub-regions of regions with the same number at different wavelengths; Figure 6 Schematic diagram for calculating the new concentration value. DETAILED DESCRIPTION

[0016] In the following description, exemplary embodiments will be described by way of example with reference to the accompanying drawings, however, additional embodiments created by arbitrarily modifying or improving the exemplary embodiments to be described below based on the common knowledge of those skilled in the art without departing from the spirit of the present disclosure are applicable.

[0017] Figure 1 A flow chart showing a first embodiment of the present invention is shown. Figure 1 As shown, the method includes: S1, using multiple test strips with known concentrations to measure the reflectance at different wavelengths, constructing a triplet of wavelength, reflectance and concentration; performing curve fitting on the reflectance and concentration in the triplet of the same wavelength; In the dry biochemical analyzer, test strips are used to measure the blood potassium content. Specifically, the test strips can react with the blood potassium in the blood sample. The color change of the test strips is related to the concentration of blood potassium in the blood. If the blood potassium concentration is high, the color of the test strips is darker; if the blood potassium concentration is low, the color of the test strips is lighter. Usually, different wavelengths of light are used to illuminate the test strips, and then the intensity of its reflected light is measured to infer the blood potassium concentration.

[0018] In the present invention, a group of standard test strips with known blood potassium concentrations are prepared in advance, and the blood potassium concentration of each test strip is known, such as 3mmol / L, 4mmol / L, 5mmol / L, etc. For each test strip, light of different wavelengths is used for irradiation, and their reflectivity is measured. Assume that these test strips are irradiated with light of different wavelengths such as 450 nm, 550nm and 650nm, and their reflectivity is recorded. For example, at 450nm, the reflectivity of test strip A is 40%, the reflectivity of test strip B is 35%, and the reflectivity of test strip C is 30%. Then, a triplet is obtained based on the wavelength, concentration, and reflectivity. An exemplary triplet is <450, 3, 0.4>, wherein 450 represents the wavelength, 3 represents the blood potassium concentration, and 0.4 represents the reflectivity, that is, the reflectivity of the test strip with a standard blood potassium concentration of 3mmol / L irradiated with a wavelength of 450nm is 0.4. Next, curve fitting is performed on the triplets at the same wavelength, so that each wavelength corresponds to a standard curve, Figure 2 When measuring the blood potassium concentration of the test paper strip, the same wavelength is used to illuminate the test paper strip to obtain the reflectivity, and the blood potassium concentration can be obtained from the standard curve corresponding to the wavelength.

[0019] The standard curve is established based on known standard sample data. However, it is precisely because the standard curve is established based on standard sample data of known blood potassium concentration that the standard curve itself has errors. On the one hand, standard samples of known blood potassium concentration cannot completely cover all reflectances of the standard curve, which involves the error of constructing the standard curve based on the reflectance of a limited number of known standard samples. For example, the standard blood potassium concentration is 3mmol / L and 4mmol / L, and there is no data between 3mmol / L-4mmol / L. If the blood potassium concentration to be measured is 3.2mmol / L, it is necessary to infer the actual concentration from the data of the blood potassium sample of known concentration; on the other hand, the relationship between reflectance and blood potassium concentration is not completely linear. Constructing a standard curve based on known standard samples will involve curve fitting, and curve fitting will involve errors. In an optional embodiment, such as Figure 3 As shown, the curve fitting of the reflectivity and concentration in the triplet of the same wavelength is specifically: S101, for a set of triples consisting of triplets with the same wavelength, taking the reflectivity in the set as an independent variable and the concentration in the set as a dependent variable, curve fitting is performed on each set of triples to obtain a curve corresponding to the wavelength; A triplet is a data consisting of reflectance, concentration and wavelength. A triplet set includes multiple triplets, and the wavelengths of triplets in the same triplet set are the same. For example, for light with a wavelength of 450 nm, if there are several standard test strips with known concentrations, their reflectances are measured to be 60%, 55%, and 30%, respectively, and the corresponding blood potassium concentrations are 3mmol / L, 4mmol / L, and 5mmol / L. For these triplets with the same wavelength, we use reflectance as the independent variable and concentration as the dependent variable to perform curve fitting. S102, using the reflectivity of the triples in the triple set to divide the curve into a plurality of regions, and numbering the regions; After the curve is fitted, the curve is divided into multiple regions. Specifically, the region is divided into multiple regions according to the reflectivity data in the triplet set. For ease of expression, it is assumed that the reflectivity in the triplet is 30%, 34%, and 41%. According to these reflectivities, the fitting curve is divided into different regions. Each region corresponds to a reflectivity interval. The first interval is 30%-34%, and the second interval is 34%-41%. Each segmented region is numbered in the order of increasing reflectivity. For example, the first interval is numbered 1, the second interval is numbered 2, and so on. That is, the curve is segmented according to the reflectivity in the triplet. Figure 4 A schematic diagram showing a first region obtained by segmenting a curve of one wavelength.

[0020] Since multiple wavelengths are used to illuminate the same standard test strip, the concentrations corresponding to the reflectances at the start of intervals with the same interval number in the curves of different wavelengths are the same, and the concentrations corresponding to the reflectances at the end of the intervals are also the same.

[0021] S103, extracting all regions with the same wavelength number to obtain a region set with the same number, dividing each region in the region set into the same number of sub-regions according to the reflectivity, and calculating the average concentration value of the endpoint reflectivity of the sub-regions with the same number on the curve; The regions with the same number are extracted to form a region set, and the regions in each region set have the same number. The reflectivity range in each region can be further subdivided into sub-regions by evenly dividing the region into several sub-regions. For example, the reflectivity range of one region in the first region set is 30%-34%. If it is divided into 4 sub-regions, the ranges are 30%-31%, 31%-32%, 32%-33%, and 33%-34% respectively. The reflectivity range of another region in the first region set is 31%-36%. Similarly, it is evenly divided into 4 sub-ranges of 31%-32.25%, 32.25%-33.5%, 33.5%-34.75%, and 34.75%-36%. Each sub-region has an endpoint reflectivity, that is, the reflectivity of the right endpoint of the sub-region. The endpoint reflectivity of each sub-region is substituted into the previously fitted standard curve, the concentration value corresponding to the reflectivity is calculated, and the average value of the concentration values ​​corresponding to the endpoint reflectivities of the sub-regions with the same number in a region is further calculated, and this average value is used as the new concentration value of the endpoint reflectivity of the sub-regions with the same number in the same region. Figure 5 A schematic diagram showing sub-regions of the same numbered region at two different wavelengths, from Figure 5 It can be seen that the areas with the same number have different reflectances but the same concentrations. This is because the concentrations of the standard test strips used are the same. For the same standard test strip, the reflectances of light of different wavelengths are different.

[0022] S104, inserting an average value of concentration values ​​corresponding to the sub-region endpoint reflectance at the sub-region endpoint reflectance of each region in the region set; Insert the end point reflectance of the sub-region and the new concentration value of the end point reflectance into the region where the sub-region is located. In the above way, all regions corresponding to each wavelength will have new values ​​inserted. Figure 6 The average value of the calculated new concentration value is shown, and this average value is used as the new concentration value at the end point of the sub-region, for example Figure 6 The new concentration value at the end point of the first sub-region of the left curve is the calculated average value, Figure 6 The new concentration value at the end point of the first sub-region of the right-hand curve is also the calculated average value.

[0023] S105 , performing curve fitting on the reflectance and concentration of each wavelength according to the interpolated values ​​and triplet in the region.

[0024] After interpolating the new concentration values, these interpolated concentration values, together with the original triplet data, are used to refit the curve.

[0025] During the measurement process, light sources of different wavelengths are used to illuminate the test strip to be tested. When light waves of different wavelengths pass through or reflect onto the surface of the strip, the reflectivity of the test strip will change. The reflectivity data of the test strip is substituted into the standard curve fitted by S1, and the corresponding blood potassium concentration at each wavelength is calculated through the mathematical relationship of the standard curve.

[0026] It should be noted that each wavelength has a standard curve. The standard curve is first established based on test strips with known blood potassium concentrations. Each test strip with a known concentration has a known concentration. When there are many test strips with known concentrations, when the same wavelength irradiates these test strips with known concentrations, each test strip with a known concentration has a reflectivity. For the same wavelength, there will be a lot of reflectivity-blood potassium concentration data, and these data are curve-fitted to obtain the standard curve of this wavelength.

[0027] After establishing a standard curve at each wavelength, the standard curve of each wavelength is divided into multiple segments or regions. The dividing line is the reflectance in the above-mentioned reflectance-blood potassium concentration. Since the number of test strips with known concentrations is the same for each wavelength, the number of regions divided into the standard curve of each wavelength is the same, but the width of the region with the same number may be different. This is because the reflectance of the same test strip with known concentration is different for different wavelengths.

[0028] In different area sets, the similarities of the areas in the area sets are different. If the difference between each area in an area set is relatively large, a finer sub-area division is required. On the contrary, if the difference between each area in an area set is not large, the number of sub-areas can be reduced, which can reduce the amount of calculation. In an optional embodiment, each area in the area set is divided into the same number of sub-areas according to the reflectivity, specifically: Obtaining a ratio of the width of each region in the region set, and determining a moving step length of each region according to the ratio; Starting from the starting point of each area, each time the moving step is moved to obtain a value on the curve, and calculating the coefficient of variation of the values ​​on the curves of different areas in the area set when the same number of steps are moved; Determining the number of sub-intervals based on the average value of the coefficient of variation; Each region in the region set is divided into sub-intervals of the number of sub-intervals.

[0029] For the regions in a region set, calculate the width of each region in the region set, that is, the reflectivity range, and then calculate the ratio of these widths. For example, if the reflectivity range of a region is 30% to 40%, its width is 0.1. If the reflectivity range of another region is 40% to 52%, its width is 0.12. Based on the ratio of each region width, determine the moving step size, which is the step size of each movement, for example, the moving step size of a width of 0.1 is 0.1, and the moving step size of a width of 0.12 is 0.12.

[0030] Starting from the reflectivity of the starting point of each area, move forward according to the calculated moving step length to obtain the corresponding reflectivity value. For each reflectivity value, the corresponding concentration value is calculated by the known fitting curve. When each area in the area set moves one step according to the moving step length of the area, the value on the curve corresponding to the wavelength is obtained from the curve, that is, the concentration value, and then the coefficient of variation of the concentration value corresponding to each area in the area set after moving this step is calculated. The specific calculation method of the coefficient of variation is the ratio of the standard deviation to the average value. After moving to the last step and calculating the coefficient of variation of the last step, the average value of all coefficients of variation in the area set is calculated. If the average value of the coefficient of variation is large, it indicates that the difference between the curves in the area set is relatively large, then the number of sub-intervals is increased, otherwise, the number of sub-intervals is reduced. More specifically, if the average value of the coefficient of variation of a certain area set is large, it is divided into 8 sub-intervals; if the coefficient of variation is small, it is divided into 4 sub-intervals; if the coefficient of variation is at an intermediate level, it is divided into 6 sub-intervals.

[0031] S2, irradiating the test paper strip with light of different wavelengths to obtain the reflectivity corresponding to each wavelength, and determining the blood potassium concentration corresponding to the reflectivity of each wavelength of the test paper strip from the fitting curve; S3, for each wavelength, find two triplets with the same wavelength as the test strip and the closest reflectance, calculate the distance between the reflectance of the test strip and the reflectance of the two triplets with the closest reflectance, determine the credibility of the blood potassium concentration of the test strip based on the distance, and use the credibility of the blood potassium concentration to calculate the corrected blood potassium concentration.

[0032] In S2, the reflectivity of each wavelength is obtained, and two triplets with the same wavelength and the closest reflectivity as the test strip are found, that is, two triplets with the same wavelength as the irradiated test strip and the closest reflectivity to the reflectivity obtained by irradiating the test strip are found. For example, if the reflectivity of the test strip at a wavelength of 450nm is 40%, then the two triplets with a wavelength of 450nm and a reflectivity closest to 40% are (450 nm, 38%, 3 mmol / L) and (450 nm, 44%, 2.6mmol / L). The distances between the reflectivity of the test strip and the reflectivity in the two closest triplets are 0.02 and 0.04. Since the triplets are obtained by test strips of known concentrations rather than by fitting, the closer the points are to the triplets curve, the greater the reliability and the smaller the fitting error. In an optional embodiment, the credibility of the blood potassium concentration of the test strip based on the distance is determined as follows: Calculate the distance between the reflectivity of the paper strip to be tested and the reflectivity in the closest triplet and use it as the closest distance, and calculate the distance between the reflectivity of the paper strip to be tested and the reflectivity in the second closest triplet and use it as the second closest distance; The sum of the closest distance and the second closest distance is calculated, and the ratio of the second closest distance to the sum is used as the reliability of the blood potassium concentration.

[0033] Still taking the above data as an example, the closest distance is 0.02, the second closest distance is 0.04, and the reliability is 0.67.

[0034] After obtaining the credibility and the blood potassium concentration, the credibility is used to recalculate the blood potassium concentration to obtain the corrected blood potassium concentration. In one embodiment, the credibility is used to perform weighted summation on the blood potassium concentration, and the ratio of the weighted summation result and the sum of the credibility is used as the corrected blood potassium concentration.

[0035] For example, when the test paper strip is irradiated with a wavelength of 450nm, the blood potassium concentration is 3mmol / L, and the reliability is 0.67. When the test paper strip is irradiated with a wavelength of 550nm, the blood potassium concentration is 3.2mmol / L, and the reliability is 0.61. Then the corrected blood potassium concentration is 3.093mmol / L.

[0036] In a second aspect of the present invention, a blood potassium detection data correction system is provided, the system comprising: A standard curve construction module is used to measure the reflectance of different wavelengths using multiple test strips of known concentrations to construct a triple consisting of wavelength, reflectance and concentration; and to perform curve fitting on the reflectance and concentration in the triple of the same wavelength; The blood potassium concentration acquisition module is used to irradiate the test paper strip with light of different wavelengths to obtain the reflectivity corresponding to each wavelength, and determine the blood potassium concentration corresponding to the reflectivity of each wavelength of the test paper strip from the fitting curve; The data correction module is used to find, for each wavelength, two triplets with the same wavelength as the paper strip to be tested and the closest reflectance, calculate the distance between the reflectance of the paper strip to be tested and the reflectance in the two triplets with the closest reflectance, determine the credibility of the blood potassium concentration of the paper strip to be tested based on the distance, and calculate the corrected blood potassium concentration using the credibility of the blood potassium concentration.

[0037] Preferably, the curve fitting of the reflectivity and concentration in the triplet of the same wavelength is specifically as follows: For a set of triples consisting of triplets with the same wavelength, the reflectivity in the set is taken as the independent variable, the concentration in the set is taken as the dependent variable, and a curve corresponding to the wavelength is obtained by curve fitting for each set of triples; Using reflectances of triplets in the triplet set to divide the curve into a plurality of regions, and numbering the regions; Extracting all regions with the same number at all wavelengths to obtain a region set with the same number, dividing each region in the region set into the same number of sub-regions according to the reflectivity, and calculating the average concentration value of the endpoint reflectivity of the sub-regions with the same number on the curve; Inserting the average value of the concentration values ​​corresponding to the sub-region endpoint reflectance at the sub-region endpoint reflectance of each region in the region set; Curve fits were made for reflectance and concentration at each wavelength based on the interpolated values ​​and triplets in the region.

[0038] Preferably, the step of evenly dividing each region in the region set into the same number of sub-regions according to reflectivity is specifically as follows: Obtaining a ratio of the width of each region in the region set, and determining a moving step length of each region according to the ratio; Starting from the starting point of each area, each time the moving step is moved to obtain a value on the curve, and calculating the coefficient of variation of the values ​​on the curves of different areas in the area set when the same number of steps are moved; Determining the number of sub-intervals based on the average value of the coefficient of variation; Each region in the region set is divided into sub-intervals of the number of sub-intervals.

[0039] Preferably, the reliability of determining the blood potassium concentration of the test paper strip based on the distance is specifically: Calculate the distance between the reflectivity of the paper strip to be tested and the reflectivity in the closest triplet and use it as the closest distance, and calculate the distance between the reflectivity of the paper strip to be tested and the reflectivity in the second closest triplet and use it as the second closest distance; The sum of the closest distance and the second closest distance is calculated, and the ratio of the second closest distance to the sum is used as the reliability of the blood potassium concentration.

[0040] Preferably, the corrected blood potassium concentration is obtained by using the credibility calculation of the blood potassium concentration, specifically: The blood potassium concentration is weighted and summed using the credibility, and the ratio of the weighted summation result and the sum of the credibility is used as the corrected blood potassium concentration. The embodiments of the present invention may also be implemented by providing software (program) for performing the functions of the above-described embodiments to a system or device via a network or various storage media, and a computer or a central processing unit (CPU) or a microprocessing unit (MPU) of the system or device reads and executes the program.

[0041] While the present invention has been described with reference to exemplary embodiments, it is to be understood that the invention is not limited to the disclosed exemplary embodiments.The scope of the following claims is to be accorded the broadest interpretation so as to encompass all such modifications and equivalent structures and functions.

[0042] Although the preferred embodiments of the present application have been described, those skilled in the art may make additional changes and modifications to these embodiments once they are aware of the basic creative concepts. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments and all changes and modifications that fall within the scope of the present application. Obviously, those skilled in the art may make various changes and modifications to the present application without departing from the spirit and scope of the present application. Thus, if these modifications and variations of the present application fall within the scope of the claims of the present application and their equivalents, the present application is also intended to include these modifications and variations.

Claims

1. A method for correcting blood potassium detection data, characterized in that: The method comprises: Using multiple test strips with known concentrations to measure the reflectance at different wavelengths, constructing a triplet of wavelength, reflectance and concentration; performing curve fitting on the reflectance and concentration in the triplet of the same wavelength; Using light of different wavelengths to illuminate the test paper strip to obtain the reflectance corresponding to each wavelength, and determining the blood potassium concentration corresponding to the reflectance of each wavelength of the test paper strip from the fitting curve; For each wavelength, find two triplets with the same wavelength as the test strip and the closest reflectance, calculate the distance between the reflectance of the test strip and the reflectance in the two triplets with the closest reflectance, determine the credibility of the blood potassium concentration of the test strip based on the distance, and use the credibility of the blood potassium concentration to calculate the corrected blood potassium concentration.

2. The method according to claim 1, characterized in that The curve fitting of the reflectivity and concentration in the triplet of the same wavelength is specifically as follows: For a set of triples consisting of triplets with the same wavelength, the reflectivity in the set is taken as the independent variable, the concentration in the set is taken as the dependent variable, and a curve corresponding to the wavelength is obtained by curve fitting for each set of triples; Using reflectances of triplets in the triplet set to divide the curve into a plurality of regions, and numbering the regions; Extracting all regions with the same number at all wavelengths to obtain a region set with the same number, dividing each region in the region set into the same number of sub-regions according to the reflectivity, and calculating the average concentration value of the endpoint reflectivity of the sub-regions with the same number on the curve; Inserting the average value of the concentration values ​​corresponding to the sub-region endpoint reflectance at the sub-region endpoint reflectance of each region in the region set; Curve fits were made for reflectance and concentration at each wavelength based on the interpolated values ​​and triplets in the region.

3. The method according to claim 2, characterized in that The step of dividing each region in the region set into the same number of sub-regions according to the reflectivity is as follows: Obtaining a ratio of the width of each region in the region set, and determining a moving step length of each region according to the ratio; Starting from the starting point of each area, each time the moving step is moved to obtain a value on the curve, and calculating the coefficient of variation of the values ​​on the curves of different areas in the area set when the same number of steps are moved; Determining the number of sub-intervals based on the average value of the coefficient of variation; Each region in the region set is divided into sub-intervals of the number of sub-intervals.

4. The method according to claim 1, characterized in that The reliability of determining the blood potassium concentration of the test paper strip based on the distance is specifically as follows: Calculate the distance between the reflectivity of the paper strip to be tested and the reflectivity in the closest triplet and use it as the closest distance, and calculate the distance between the reflectivity of the paper strip to be tested and the reflectivity in the second closest triplet and use it as the second closest distance; The sum of the closest distance and the second closest distance is calculated, and the ratio of the second closest distance to the sum is used as the reliability of the blood potassium concentration.

5. The method according to claim 1, characterized in that The corrected blood potassium concentration is obtained by using the credibility calculation of the blood potassium concentration, specifically: The blood potassium concentration is weighted and summed using the credibility, and the ratio of the weighted summation result and the sum of the credibility is used as the corrected blood potassium concentration.

6. A blood potassium detection data correction system, characterized in that: The system comprises: A standard curve construction module is used to measure the reflectance of different wavelengths using multiple test strips of known concentrations to construct a triple consisting of wavelength, reflectance and concentration; and to perform curve fitting on the reflectance and concentration in the triple of the same wavelength; The blood potassium concentration acquisition module is used to irradiate the test paper strip with light of different wavelengths to obtain the reflectivity corresponding to each wavelength, and determine the blood potassium concentration corresponding to the reflectivity of each wavelength of the test paper strip from the fitting curve; The data correction module is used to find, for each wavelength, two triplets with the same wavelength as the paper strip to be tested and the closest reflectance, calculate the distance between the reflectance of the paper strip to be tested and the reflectance in the two triplets with the closest reflectance, determine the credibility of the blood potassium concentration of the paper strip to be tested based on the distance, and calculate the corrected blood potassium concentration using the credibility of the blood potassium concentration.

7. The system according to claim 6, characterized in that The curve fitting of the reflectivity and concentration in the triplet of the same wavelength is specifically as follows: For a set of triples consisting of triplets with the same wavelength, the reflectivity in the set is taken as the independent variable, the concentration in the set is taken as the dependent variable, and a curve corresponding to the wavelength is obtained by curve fitting for each set of triples; Using reflectances of triplets in the triplet set to divide the curve into a plurality of regions, and numbering the regions; Extracting all regions with the same number at all wavelengths to obtain a region set with the same number, dividing each region in the region set into the same number of sub-regions according to the reflectivity, and calculating the average concentration value of the endpoint reflectivity of the sub-regions with the same number on the curve; Inserting the average value of the concentration values ​​corresponding to the sub-region endpoint reflectance at the sub-region endpoint reflectance of each region in the region set; Curve fits were made for reflectance and concentration at each wavelength based on the interpolated values ​​and triplets in the region.

8. The system according to claim 7, characterized in that The step of dividing each region in the region set into the same number of sub-regions according to the reflectivity is as follows: Obtaining a ratio of the width of each region in the region set, and determining a moving step length of each region according to the ratio; Starting from the starting point of each area, each time the moving step is moved to obtain a value on the curve, and calculating the coefficient of variation of the values ​​on the curves of different areas in the area set when the same number of steps are moved; Determining the number of sub-intervals based on the average value of the coefficient of variation; Each region in the region set is divided into sub-intervals of the number of sub-intervals.

9. The system according to claim 6, characterized in that The reliability of determining the blood potassium concentration of the test paper strip based on the distance is specifically as follows: Calculate the distance between the reflectivity of the paper strip to be tested and the reflectivity in the closest triplet and use it as the closest distance, and calculate the distance between the reflectivity of the paper strip to be tested and the reflectivity in the second closest triplet and use it as the second closest distance; The sum of the closest distance and the second closest distance is calculated, and the ratio of the second closest distance to the sum is used as the reliability of the blood potassium concentration.

10. The system according to claim 6, characterized in that The corrected blood potassium concentration is obtained by using the credibility calculation of the blood potassium concentration, specifically: The blood potassium concentration is weighted and summed using the credibility, and the ratio of the weighted summation result and the sum of the credibility is used as the corrected blood potassium concentration.

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