Screening method of acting protein targets of traditional Chinese medicine
Through microarray chip technology and fluorophore-modified probes, the identification of target proteins in the complex chemical system of traditional Chinese medicine has solved the complexity and difficulty of the target screening process in the existing technology, and achieved rapid and economical target detection. Suitable for the research of a variety of complex Chinese medicine systems and the development of new drugs.
CN119290840AActive Publication Date: 2025-01-10EXPERIMENTAL RES CENT CHINA ACAD OF CHINESE MEDICAL SCI
Patent Information
- Application Number
- CN202411832715.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-13
- Publication Date
- 2025-01-10
- Estimated Expiration
- 2044-12-13
Smart Images
Figure CN119290840A_ABST
Abstract
The invention provides a screening method of traditional Chinese medicine acting protein targets, and belongs to the technical field of biological medicine. The probe competes with the traditional Chinese medicine chemical system, the traditional Chinese medicine molecules combined with the target can weaken the combination of the probe, and the signal intensity is reduced after the target is combined with the traditional Chinese medicine molecules, so that whether the traditional Chinese medicine chemical system is combined with the target is judged, and the binding site can be determined; the problems that in the prior art, a traditional Chinese medicine chemical system is complex, so that molecular marking of all compounds is difficult to achieve, and target screening cannot be completed are solved. Traditional Chinese medicine molecules do not need to be marked, target screening of a traditional Chinese medicine complex chemical system can be detected in a short time, the method is economical and rapid, detection results are based on competitive molecules, specificity is high, signals are stable, and the method is suitable for application and popularization.
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Citation Information
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