Preparation device and preparation method of silybum marianum phospholipid complex

Abstract

The invention relates to the field of preparation of silybum marianum phospholipid complexes, in particular to a preparation device and a preparation method of a silybum marianum phospholipid complex. According to the preparation device of the silybum marianum phospholipid complex, the detachable central rotating shaft rotating pipeline and the settling cylinder are arranged in the decompression chamber and the fixed cover correspondingly, raw materials are continuously pumped into the settling cylinder, precipitated precipitates are sequentially collected into a collecting hopper structure of the settling cylinder, the precipitates are collected in the stirring process, and the stirring efficiency is improved. And precipitates collected in the settling cylinder are directly poured out in a quick dismounting manner, so that subsequent normal-temperature reduced-pressure concentration treatment work can be carried out in the reduced-pressure chamber, and three treatment work of multi-batch solution synthesis, precipitation separation and normal-temperature reduced-pressure concentration can be carried out in the reduced-pressure chamber. The technical defect that the treatment efficiency and the preparation effect of the silybum marianum phospholipid complex can be affected when a solution is transferred back and forth in various treatment devices to prepare the silybum marianum phospholipid complex is overcome.

Description

Technical Field

[0001] The invention relates to the field of preparation of silybum marianum phospholipid complex, and in particular to a preparation device and a preparation method of silybum marianum phospholipid complex. Background Art

[0002] The silymarin phospholipid complex is a complex formed by combining silymarin with phospholipids. The preparation method generally comprises dissolving the silymarin extract and phospholipids in an organic solvent such as ethanol, then clarifying the solution by stirring, and finally removing the solvent by evaporation or vacuum to obtain the complex. In this process, the solvent needs to be frequently replaced and the precipitate needs to be separated and treated. Therefore, the solution needs to be transferred in a variety of processing equipment, which not only affects the overall preparation efficiency of the silymarin phospholipid complex, but also easily leads to a large amount of waste of the silymarin phospholipid complex raw material liquid due to incomplete precipitation separation, affecting the overall preparation effect of the silymarin phospholipid complex. Summary of the invention

[0003] In order to overcome the disadvantage that the preparation of silymarin phospholipid complex by reciprocatingly transferring solutions in a variety of processing equipment will affect its processing efficiency and preparation effect, the present invention provides a preparation device and a preparation method for silymarin phospholipid complex.

[0004] The invention discloses a preparation device for silymarin phospholipid complex, comprising a fixed support, a decompression chamber, a top cover, a first electrically controlled lift, a first lifting support, a rotary blanking assembly, a central rotating shaft, a first stirring blade, a fixed cover, a sedimentation cylinder, a sleeve ring, a second stirring blade, an air pipe and an air extraction ring pipe; a decompression chamber for synthesis processing is installed on the fixed support; a first electrically controlled lift is installed on the fixed support; a first lifting support is slidably connected to the fixed support; the first lifting support is tightly attached to the discharge port structure through a sealing ring; a first sealing bushing is rotatably connected to the first lifting support; a lifting component of the first electrically controlled lift is fixedly connected to the first lifting support; a rotary blanking assembly is commonly connected between the first sealing bushing and the first lifting support; a central rotating shaft is detachably fixedly connected to the rotary blanking assembly, and the central rotating shaft is located inside the decompression chamber; a fixed A fixed cover; a settling cylinder is detachably fixedly connected to the fixed cover; the central rotating shaft is rotatably connected to the settling cylinder; at least two first stirring plates are fixedly connected to the central rotating shaft, and the first stirring plates are located in the settling cylinder; the discharge valve is provided with a plurality of block structures for plugging into the settling cylinder; a collecting bucket structure is provided in the settling cylinder, and the bottom surface of the collecting bucket structure does not contact the bottom surface of the inner side of the settling cylinder; a plurality of liquid inlet trough structures are provided on the settling cylinder, and the liquid inlet trough structure is located above the collecting bucket structure; a plurality of first screens are provided on the settling cylinder, and the first screens are located below the collecting bucket structure; a second screen is provided in the collecting bucket structure of the settling cylinder; a collar is connected to the central rotating shaft; at least two second stirring plates are fixedly connected to the collar, and the second stirring plates are abutted against the second screen; a second sealing bushing is fixedly connected to the top cover; an air supply pipe is connected in the second sealing bushing; the air supply pipe is connected to an exhaust ring pipe, and the exhaust ring pipe is located in the decompression chamber.

[0005] More preferably, the rotary unloading assembly includes a rotating pipe, a feed pipe head, a sealing plug, a first spur gear, a driving motor and a second spur gear; the rotating pipe is slidably connected in the first sealing sleeve; the feed pipe head is fixedly connected to the first lifting bracket; one end of the feed pipe head is rotatably connected to the rotating pipe; a sealing plug is inserted at the other end of the feed pipe head; the first spur gear is fixedly connected to the feed pipe head; the driving motor is installed on the first lifting bracket; the output shaft of the driving motor is fixedly connected to the second spur gear; the second spur gear is meshed with the first spur gear; the rotating pipe is rotatably connected to the fixed cover; the central shaft is detachably fixedly connected to the rotating pipe.

[0006] More preferably, a retaining ring is fixedly connected to the bottom of the collecting bucket structure of the sedimentation cylinder.

[0007] More preferably, the retaining ring is provided with a plurality of through-groove structures.

[0008] More preferably, a baffle is fixedly connected to the collar; and a discharge groove structure corresponding to the second stirring blade is formed on the baffle.

[0009] More preferably, the collar is slidably connected to the central shaft; a compression spring is fixedly connected between the collar and the central shaft.

[0010] More preferably, the gas pipe is slidably connected to the second sealing bushing; a second electrically-controlled lifter is installed on the fixed bracket; the second lifting bracket is slidably connected to the fixed bracket; the lifting component of the second electrically-controlled lifter is fixedly connected to the second lifting bracket; and the second lifting bracket is fixedly connected to the gas pipe.

[0011] A method for preparing a silymarin phospholipid complex comprises the following steps: Step 1, synthesis of the first solution, pouring a mixed solution of silybin: PC50-PC90 phospholipids = 1:0.5-1:2 and a first organic extraction solvent into a decompression chamber, stirring and mixing, and completing the solution synthesis process; Step 2, first precipitation separation, in the process of step 1, the precipitate precipitated from the solution in the decompression chamber is continuously collected into the sedimentation cylinder, and after the solution synthesis process is completed, the precipitate collected in the sedimentation cylinder is poured out; Step 3, decompression concentration at room temperature, at room temperature, the remaining solution in the decompression chamber is subjected to decompression concentration treatment to concentrate the solution volume to less than one tenth of the original volume; Step 4, synthesizing the second solution, pouring the second organic extraction solvent into the concentrated solution in the decompression chamber, stirring and mixing, and completing the solution synthesis process; Step five, second precipitation separation, during the processing work in step four, the precipitate precipitated from the solution in the decompression chamber is continuously collected into the sedimentation cylinder. After the solution synthesis treatment is completed, the precipitate in the sedimentation cylinder is collected and dried.

[0012] More preferably, the first organic extraction solvent is a mixed solution of 95% ethanol, ethyl acetate and acetone, and the ratio of ethanol:ethyl acetate:acetone is 2:1:2.

[0013] More preferably, the second organic extraction solvent is a mixed solution of n-hexane, dichloromethane and petroleum ether, and the ratio of n-hexane: dichloromethane: petroleum ether is 3:0.5:4.

[0014] Compared with the prior art, the present invention has the following advantages: a preparation device for silymarin phospholipid complex of the present invention, a detachable central shaft rotating pipeline and a sedimentation cylinder are respectively provided through and fixedly covered in the decompression chamber, raw materials are continuously pumped into the sedimentation cylinder, and the precipitates are collected in the collecting bucket structure of the sedimentation cylinder in turn, the precipitates are collected during the stirring process, and the precipitates collected in the sedimentation cylinder are directly poured out through a quick disassembly method, and subsequent normal temperature decompression and concentration treatment can be carried out in the decompression chamber, so that the three treatments of solution synthesis, precipitation separation and normal temperature decompression and concentration are all carried out in the decompression chamber, and there is no need to frequently transfer the solution between multiple devices; the technical disadvantage that the preparation of silymarin phospholipid complex by reciprocatingly transferring the solution in multiple treatment equipment will affect its treatment efficiency and preparation effect is overcome. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 A schematic diagram of the first viewing angle structure of the present invention is provided; Figure 2 A schematic diagram of the second viewing angle structure of the present invention is provided; Figure 3 A cross-sectional view of the decompression chamber structure for describing the present invention; Figure 4 An exploded view of the feed pipe head and the sealing plug structure of the present invention is provided; Figure 5 A cross-sectional view of the structure of the sedimentation tube of the present invention is described; Figure 6 A schematic diagram of the central shaft structure of the present invention is provided; Figure 7 A cross-sectional view of the sedimentation tube and retaining ring structure for describing the present invention; Figure 8 The schematic diagram of the baffle structure of the present invention is described.

[0016] The markings of the components in the accompanying drawings are as follows: 1-fixed bracket, 21-decompression chamber, 22-discharge valve, 221-block structure, 23-top cover, 230-discharge port structure, 24-first sealing bushing, 25-first electric lift, 26-first lifting bracket, 27-second sealing bushing, 28-second electric lift, 29-second lifting bracket, 31-rotating pipe, 32-feed pipe head, 33-sealing plug, 34-first straight gear , 35-drive motor, 36-second spur gear, 37-center shaft, 38-first stirring blade, 41-fixed cover, 42-sedimentation cylinder, 421-collecting bucket structure, 422-liquid inlet tank structure, 423-first screen, 424-second screen, 5-blocking ring, 50-through groove structure, 51-sleeve ring, 52-second stirring blade, 53-baffle, 530-discharge groove structure, 54-compression spring, 61-air supply pipe, 62-exhaust ring pipe. DETAILED DESCRIPTION

[0017] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0018] Example 1 A preparation device for milk thistle phospholipid complex, such as Figure 1-Figure 8As shown, it includes a fixed support 1, a decompression chamber 21, a top cover 23, a first electrically controlled lift 25, a first lifting support 26, a rotary unloading assembly, a central shaft 37, a first stirring blade 38, a fixed cover 41, a sedimentation cylinder 42, a collar 51, a second stirring blade 52, an air pipe 61 and an air extraction ring pipe 62; the fixed support 1 is equipped with a decompression chamber 21; the bottom of the decompression chamber 21 is connected to a discharge valve 22; the top cover 23 is fixedly connected to the top of the decompression chamber 21; a discharge port structure 230 is provided on the top cover 23; the fixed support 1 is equipped with a first electrically controlled lift 25; the fixed support 1 is slidably connected with the first lifting support 26, and the first lifting support 26 is composed of a disc-shaped fixed contact with the top cover 23. The first lifting bracket 26 is composed of a disc fixing frame and a C-shaped fixing frame extending horizontally outward from the surface of the disc fixing frame; the disc fixing frame of the first lifting bracket 26 is tightly attached to the discharge port structure 230 through a sealing ring; the disc fixing frame of the first lifting bracket 26 is rotatably connected with a first sealing bushing 24; the lifting component of the first electric control lift 25 is fixedly connected to the C-shaped fixing frame of the first lifting bracket 26; a rotating blanking assembly is commonly connected between the first sealing bushing 24 and the first lifting bracket 26; the rotating blanking assembly is detachably fixedly connected with a central shaft 37, and the central shaft 37 is located inside the decompression chamber 21; the rotating blanking assembly is connected with a fixing cover 41; the bottom of the fixing cover 41 is detachably fixedly connected with The sedimentation cylinder 42; the lower end of the central rotating shaft 37 is rotatably connected to the sedimentation cylinder 42; the lower end of the central rotating shaft 37 is fixedly connected to two first stirring plates 38, and the first stirring plates 38 are located in the sedimentation cylinder 42; the discharge valve 22 is provided with a plurality of block structures 221; all the block structures 221 of the discharge valve 22 are plugged into the sedimentation cylinder 42, and the discharge valve 22 fixes the sedimentation cylinder 42 through the block structure 221 to prevent the sedimentation cylinder 42 from rotating with the central rotating shaft 37, resulting in a phenomenon in which the speed of the solution entering the sedimentation cylinder 42 through the channel on the surface of the sedimentation cylinder 42 is slowed down; a collecting bucket structure 421 is provided in the sedimentation cylinder 42, and the bottom surface of the collecting bucket structure 421 does not contact the bottom surface of the sedimentation cylinder 42; the sedimentation cylinder A plurality of liquid inlet trough structures 422 are provided on 42, and the liquid inlet trough structures 422 are located above the collecting bucket structure 421; a plurality of first screens 423 are provided on the settling cylinder 42, and the first screens 423 are located below the collecting bucket structure 421; a plurality of second screens 424 are provided at the bottom of the collecting bucket structure 421 of the settling cylinder 42; a collar 51 is connected to the central rotating shaft 37; two second stirring blades 52 are fixedly connected to the collar 51, and the lower ends of the second stirring blades 52 are abutted against the second screens 424; a second sealing bushing 27 is fixedly connected to the top cover 23; an air supply pipe 61 is connected in the second sealing bushing 27; an exhaust ring pipe 62 is connected to the lower end of the air supply pipe 61, and the exhaust ring pipe 62 is located in the decompression chamber 21.

[0019] like Figure 3-Figure 6As shown, the rotary unloading assembly includes a rotating pipe 31, a feed pipe head 32, a sealing plug 33, a first spur gear 34, a driving motor 35 and a second spur gear 36; the rotating pipe 31 is fixedly connected in the first sealing bushing 24; the feed pipe head 32 is fixedly connected to the first lifting bracket 26; one end of the feed pipe head 32 is rotatably connected to the rotating pipe 31; the other end of the feed pipe head 32 is inserted with a sealing plug 33; the first spur gear 34 is fixedly connected to the rotating pipe 31; the driving motor 35 is installed on the first lifting bracket 26; the output shaft of the driving motor 35 is fixedly connected to the second spur gear 36; the second spur gear 36 is meshed with the first spur gear 34; the rotating pipe 31 is rotatably connected to the fixed cover 41; the central shaft 37 is detachably fixedly connected to the rotating pipe 31 through a plug structure, and the central shaft 37 will not block the outlet end of the rotating pipe 31.

[0020] like Figure 5-Figure 8 As shown, a baffle ring 5 is fixedly connected to the upper surface of the collecting bucket structure 421 of the sedimentation cylinder 42; a plurality of through groove structures 50 are provided on the baffle ring 5; a baffle plate 53 is fixedly connected to the sleeve ring 51; the baffle plate 53 is tightly attached to the upper surface of the baffle ring 5; and two discharge groove structures 530 corresponding to the two second stirring blades 52 are provided on the baffle plate 53.

[0021] like Figure 1-Figure 8 As shown, the collar 51 is slidably connected to the central shaft 37; a compression spring 54 is fixedly connected between the collar 51 and the central shaft 37. The compression spring 54 is initially in a compressed state. The compression spring 54 provides downward pressure to the collar 51 by the reverse elastic force after compression, so that the collar 51 presses the baffle 53 downward onto the baffle ring 5.

[0022] The solution synthesis working steps of the device for preparing the silymarin phospholipid complex of the present invention are as follows.

[0023] The operator first removes the sealing plug 33 on the feed pipe head 32, and pours the mixed raw material solution of silybin, PC50-PC90 phospholipids and organic solution into the rotating pipe 31 through the feed pipe. Figure 6 As shown, the solution flows along the rotating pipe 31 through the sedimentation cylinder 42 and passes through the liquid inlet tank structure 422 into the decompression chamber 21. At the same time, the driving motor 35 drives the second spur gear 36 to rotate. The second spur gear 36 engages with the first spur gear 34 to drive the rotating pipe 31 and the central shaft 37 to rotate. The central shaft 37 drives the first stirring blade 38 to continuously rotate and stir in the sedimentation cylinder 42 in the decompression chamber 21 to perform the synthesis treatment of the solution.

[0024] The precipitation and separation working steps of the device for preparing the silymarin phospholipid complex of the present invention are as follows.

[0025] Combination Figure 7As shown, the first stirring blade 38 continuously rotates and stirs the solution in the sedimentation cylinder 42 to form a central vortex that flows downward, so that the solution in the decompression chamber 21 enters the sedimentation cylinder 42 through the liquid inlet groove structure 422 in turn, and then the solution passes through the through groove structure 50 into the retaining ring 5, and then flows back to the decompression chamber 21 along the second screen 424 and the first screen 423 in turn, so that the solution continuously circulates through the sedimentation cylinder 42, and the precipitate precipitated in the solution will be continuously intercepted by the second screen 424, so that the precipitate is finally collected in the space above the collecting bucket structure 421 of the sedimentation cylinder 42, both inside and outside the retaining ring 5, and at the same time, the central shaft 37 drives the second stirring blade 52 to rotate above the second screen 424, and the rotating second stirring blade 52 shovels the precipitate accumulated on the second screen 424 upward, so that the second stirring blade 52 continuously flips the precipitate, reduces the accumulation of precipitate on the second screen 424, and improves the circulation efficiency of the solution flowing through the second screen 424, thereby improving the collection efficiency of the precipitate in the solution.

[0026] After the synthesis treatment of the solution is completed, the precipitate precipitated in the solution is the waste precipitate, which will be completely collected in the collecting bucket structure 421. Then the operator controls the first electrically-controlled elevator 25 to pull the first lifting bracket 26 to drive the rotating pipe 31 and the sedimentation cylinder 42 connected thereto to move upward away from the solution until the sedimentation cylinder 42 is aligned with the vacuum ring pipe 62, allowing the residual solution in the sedimentation cylinder 42 to gradually drip downward back into the solution. Then the operator controls the first electrically-controlled elevator 25 to continue pulling the first lifting bracket 26 to drive the rotating pipe 31 and the sedimentation cylinder 42 connected thereto to move upward away from the discharge port structure 230 of the top cover 23. When no solution drips downward from the sedimentation cylinder 42, the operator removes the sedimentation cylinder 42 from the fixed cover 41 and pours out the collected waste precipitate to complete the waste sedimentation separation work. When the operator removes the sedimentation cylinder 42 and the central rotating shaft 37 from the fixed cover 41 and the rotating pipe 31 respectively, and pours out the sediment collected in the sedimentation cylinder 42, if the baffle 53 is integrated with the baffle ring 5, then pouring out the waste sediment inside the baffle ring 5, inverting the entire sedimentation cylinder 42, and slowly rotating the second stirring blade 52 is a bit troublesome. If the baffle 53 is set to a movable state, the operator only needs to pull the sleeve ring 51 or the baffle 53 to move along the outer surface of the central rotating shaft 37, drive the baffle 53 to leave the baffle ring 5, and make the baffle ring 5 have an opening, so that the sediment in the baffle ring 5 can be conveniently poured out, thereby improving the convenience of discharging impurities.

[0027] The normal temperature and reduced pressure concentration working steps of the milk thistle phospholipid complex preparation device of the present invention are as follows.

[0028] After the operator reinstalls the sedimentation cylinder 42 after the sediment is emptied onto the fixed cover 41, he controls the first electrically-controlled elevator 25 to pull the first lifting bracket 26 to drive the rotating pipe 31 and the sedimentation cylinder 42 connected thereto to reset downward, so that the first lifting bracket 26 is again close to the discharge port structure 230 through the sealing ring, and the sealing plug 33 is plugged back onto the feed pipe head 32, so that the decompression chamber 21 is in a state of being connected only to the air extraction ring pipe 62. Then the operator connects the gas supply pipe 61 to an external vacuum pumping device, and the external vacuum pumping device performs a vacuum treatment in the decompression chamber 21 through the gas supply pipe 61 and the air extraction ring pipe 62, and performs a room temperature decompression and concentration treatment on the solution in the decompression chamber 21.

[0029] After completing the normal temperature decompression concentration treatment and operating the external vacuum equipment to restore the internal pressure of the decompression chamber 21, the operator will add a mixed solution of n-hexane, dichloromethane and petroleum ether into the decompression chamber 21, and then carry out the solution stirring and precipitation separation work in sequence according to the above steps, so that the desired target precipitate - silymarin phospholipid complex can be obtained in the sedimentation cylinder 42. The sedimentation cylinder 42 is lifted and the target precipitate is separated after the dripping phenomenon stops, and the discharge valve 22 is opened to discharge the excess mixed solution to complete the preparation work.

[0030] The present invention realizes that only one silymarin phospholipid complex preparation device is used to successively complete solution synthesis, precipitation separation and room temperature reduced pressure concentration, thereby reducing the number of devices used, reducing the process and time consumed for transferring raw materials between devices, and improving the preparation efficiency of the silymarin phospholipid complex. Through process exploration, equipment improvement and a combination of solvent residue removal methods, a silymarin phospholipid complex with high encapsulation rate, high drug content and solvent residue below the Chp detection limit is prepared, and the silymarin phospholipid complex is suitable for industrial production.

[0031] Example 2 like Figure 1-Figure 8 As shown, on the basis of Example 1, the air pipe 61 of this embodiment is slidably connected to the second sealing bushing 27; a second electrically-controlled lifter 28 is installed on the fixed bracket 1; the second lifting bracket 29 is slidably connected to the fixed bracket 1; the lifting component of the second electrically-controlled lifter 28 is fixedly connected to the second lifting bracket 29; the second lifting bracket 29 is fixedly connected to the air pipe 61.

[0032] In the normal temperature and reduced pressure concentration step, as the solution is continuously concentrated in the decompression chamber 21, the liquid level of the solution gradually decreases. At the same time, the second electrically controlled elevator 28 pulls the second lifting bracket 29 to drive the gas pipe 61 and the air pumping ring pipe 62 to slowly descend, so that the air pumping ring pipe 62 remains in an area close to the liquid surface of the solution. Under the suction action of the external vacuum pumping equipment, the air pumping ring pipe 62 is vacuumed, so that the excess water vapor boiled and precipitated by the solution during the concentration process is promptly sucked away by the air pumping ring pipe 62, thereby improving the concentration processing efficiency of the solution.

[0033] In the sedimentation separation step, the second electrically-controlled elevator 28 first pushes the second lifting bracket 29 to drive the gas pipe 61 and the air extraction ring pipe 62 to move upward to the liquid surface away from the solution, and then the first electrically-controlled elevator 25 pulls the first lifting bracket 26 to drive the rotating pipe 31 and the sedimentation cylinder 42 connected thereto to move upward to be aligned with the horizontal height of the air extraction ring pipe 62. After operating the external vacuum equipment to restore the internal pressure of the decompression chamber 21, the operator removes the sealing plug 33 on the feed pipe head 32, connects the feed pipe head 32 to the external drying equipment, and allows the external drying equipment to continuously transport hot air flow to the rotating pipe 31 through the feed pipe head 32. The hot air flow is ejected downward along the rotating pipe 31 into the sedimentation cylinder 42, and most of the hot air flow will leave the sedimentation cylinder 42 through the liquid inlet tank structure 422. The sediment located in the upper layer of the sedimentation cylinder 42 is dried, and at the same time, the driving motor 35 drives the second stirring blade 52 connected to the rotating pipe 31 and the central rotating shaft 37 to rotate continuously, so that the second stirring blade 52 can continuously flip the sediment in the sedimentation cylinder 42. At the same time, the second stirring blade 52 will also continuously flip the sediment in the retaining ring 5 to reduce the accumulation of sediment on the second screen 424, so that a small amount of hot air flow can pass through the second screen 424 and the first screen 423 to leave the sedimentation cylinder 42 in turn, so that this part of the hot air flow can be dried in the process of flowing through the continuously flipped sediment. At the same time, the external vacuum equipment air pipe 61 and the air extraction ring pipe 62 continue to perform vacuum treatment, and the hot air flow after passing through the sediment is sucked away in time, thereby increasing the flow rate of the hot air flow continuously flowing through the sediment and improving the drying efficiency of the sediment.

[0034] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A device for preparing a silymarin phospholipid complex, comprising: a fixed support (1); a decompression chamber (21) for synthesis processing is installed on the fixed support (1); It is characterized in that The invention also comprises a first electrically controlled lifter (25); the first electrically controlled lifter (25) is mounted on the fixed bracket (1); the first lift bracket (26) is slidably connected to the fixed bracket (1); the first lift bracket (26) is tightly attached to the discharge port structure (230) via a sealing ring; the first lift bracket (26) is rotatably connected to a first sealing bushing (24); the lift component of the first electrically controlled lifter (25) is fixedly connected to the first lift bracket (26); the first sealing bushing (24) and the first lift bracket (26) are connected together A rotary material discharging assembly is connected; the rotary material discharging assembly is detachably fixedly connected to a central rotating shaft (37), and the central rotating shaft (37) is located inside the decompression chamber (21); the rotary material discharging assembly is connected to a fixed cover (41); the fixed cover (41) is detachably fixedly connected to a sedimentation cylinder (42); the central rotating shaft (37) is rotatably connected to the sedimentation cylinder (42); the central rotating shaft (37) is fixedly connected to no less than two first stirring blades (38), and the first stirring blades (38) are located inside the sedimentation cylinder (42); the discharge valve (22) is provided with A plurality of block structures (221) plugged into a sedimentation cylinder (42); a collecting bucket structure (421) is provided in the sedimentation cylinder (42), and the bottom surface of the collecting bucket structure (421) does not contact the bottom surface of the sedimentation cylinder (42); a plurality of liquid inlet trough structures (422) are provided on the sedimentation cylinder (42), and the liquid inlet trough structures (422) are located above the collecting bucket structure (421); a plurality of first screens (423) are provided on the sedimentation cylinder (42), and the first screens (423) are located below the collecting bucket structure (421); the sedimentation cylinder ( A second screen (424) is provided in a collecting bucket structure (421) of the invention; a collar (51) is connected to the central rotating shaft (37); at least two second stirring blades (52) are fixedly connected to the collar (51), and the second stirring blades (52) are abutted against the second screen (424); a second sealing bushing (27) is fixedly connected to the top cover (23); an air supply pipe (61) is connected to the inside of the second sealing bushing (27); the air supply pipe (61) is connected to an air extraction ring pipe (62), and the air extraction ring pipe (62) is located in the decompression chamber (21).

2. The device for preparing a silymarin phospholipid complex according to claim 1, characterized in that: The rotary unloading assembly comprises a rotary pipe (31); the rotary pipe (31) is slidably connected in a first sealing bushing (24); a feed pipe head (32) is fixedly connected to a first lifting bracket (26); one end of the feed pipe head (32) is rotatably connected to the rotary pipe (31); a sealing plug (33) is inserted into the other end of the feed pipe head (32); a first spur gear (34) is fixedly connected to the feed pipe head (32); a driving motor (35) is installed on the first lifting bracket (26); a second spur gear (36) is fixedly connected to the output shaft of the driving motor (35); the second spur gear (36) is meshed with the first spur gear (34); the rotary pipe (31) is rotatably connected to a fixed cover (41); and a central rotating shaft (37) is detachably fixedly connected to the rotary pipe (31).

3. The device for preparing the silymarin phospholipid complex according to claim 1, characterized in that: A retaining ring (5) is fixedly connected to the inner bottom of the collecting bucket structure (421) of the sedimentation cylinder (42).

4. The device for preparing the silymarin phospholipid complex according to claim 3, characterized in that: A plurality of through-groove structures (50) are formed on the retaining ring (5).

5. The device for preparing the silymarin phospholipid complex according to claim 4, characterized in that: A baffle plate (53) is fixedly connected to the collar (51); a discharge groove structure (530) corresponding to the second stirring blade (52) is provided on the baffle plate (53).

6. The device for preparing the silymarin phospholipid complex according to claim 5, characterized in that: The collar (51) is slidably connected to the central rotating shaft (37); a compression spring (54) is fixedly connected between the collar (51) and the central rotating shaft (37).

7. The device for preparing the silymarin phospholipid complex according to claim 1, characterized in that: The gas delivery pipe (61) is slidably connected to the second sealing bushing (27); a second electrically controlled lifter (28) is mounted on the fixed bracket (1); a second lifting bracket (29) is slidably connected to the fixed bracket (1); a lifting component of the second electrically controlled lifter (28) is fixedly connected to the second lifting bracket (29); and the second lifting bracket (29) is fixedly connected to the gas delivery pipe (61).

8. A method for preparing a silymarin phospholipid complex, the method using a silymarin phospholipid complex preparation device according to any one of claims 1 to 7, characterized in that: The following steps are included: Step 1, synthesis of the first solution, pouring a mixed solution of silybin: PC50-PC90 phospholipids at a ratio of 1:0.5-1:2 and a first organic extraction solvent into a decompression chamber (21), stirring and mixing, and completing the solution synthesis process; Step 2, first precipitation separation, during the treatment work in step 1, the precipitate precipitated from the solution in the decompression chamber (21) is continuously collected into the sedimentation cylinder (42), and after the solution synthesis treatment is completed, the precipitate collected in the sedimentation cylinder (42) is poured out; Step 3, decompression concentration at room temperature, at room temperature, the remaining solution in the decompression chamber (21) is subjected to decompression concentration treatment to concentrate the volume of the solution to less than one tenth of the original volume; Step 4, synthesizing the second solution, pouring the second organic extraction solvent into the concentrated solution in the decompression chamber (21), stirring and mixing, and completing the solution synthesis process; Step five, second precipitation separation, during the processing work in step four, the precipitate precipitated from the solution in the decompression chamber (21) is continuously collected into the sedimentation cylinder (42), and after the solution synthesis process is completed, the precipitate in the sedimentation cylinder (42) is collected and dried.

9. The method for preparing a silymarin phospholipid complex according to claim 8, characterized in that: The first organic extraction solvent used was a mixed solution of 95% ethanol, ethyl acetate, and acetone, with ethanol: ethyl acetate: acetone = 2:1:

2.

10. The method for preparing a silymarin phospholipid complex according to claim 8, characterized in that: The second organic extraction solvent used was a mixed solution of n-hexane, dichloromethane, and petroleum ether, and the ratio of n-hexane: dichloromethane: petroleum ether was 3:0.5:4.

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