Kit for extracting residual HCD through paramagnetic particle method

Abstract

The invention relates to a magnetic bead method residual HCD extraction kit which comprises a kit body and a kit cover used in cooperation with the kit body, the kit body comprises a bottom box and a storage box installed at the top of the bottom box, the top of the storage box is provided with a plurality of storage grooves extending into the bottom box, and the bottom box is provided with a magnetic bead method. Test tube protection mechanisms are arranged in the multiple storage grooves, each protection mechanism comprises a protection barrel used in cooperation with the storage box, an air bag installed on the inner wall of the protection barrel and a first magnetic block installed at the bottom of the protection barrel, and multiple air inlet holes are formed in the top of each protection barrel; in the using process, the air bag can be inflated through the arranged inflation mechanism, at the moment, the air bag can bulge, a test tube can be wrapped, in this way, the test tube can be fixed, pressure borne by the test tube can be relieved due to the fact that the air bag has certain deformation resistance, and the test tube is more convenient to use. The condition that the test tube is broken in the transportation process is reduced.

Description

Technical Field

[0001] The invention belongs to the technical field of graphite processing, and particularly relates to a kit for extracting residual HCD using a magnetic bead method. Background Art

[0002] HCD refers to the residual DNA in the host cells, and its sources include the host cell genome and plasmid. The presence of HCD may have a negative impact on the quality and safety of protein drugs, such as inflammatory response and immunogenicity. The kit is a box used to hold chemical reagents for detecting chemical components, drug residues, virus types, etc. The residual HCD extraction kit is a storage box for residual HCD extraction reagents.

[0003] The existing residual HCD extraction kit based on the magnetic bead method has a relatively simple structure. Although the reagent tube is fixed and limited by a fixing mechanism during use, when the reagent tube is squeezed by an external force, the fixing mechanism used to fix the reagent tube in the reagent tube cannot effectively protect the reagent tube, which may cause the reagent tube to burst due to squeezing or collision, making it inconvenient for people to use. Summary of the invention

[0004] The purpose of the present invention is to provide a magnetic bead method residual HCD extraction kit with simple structure and reasonable design in order to solve the above problems.

[0005] The present invention achieves the above-mentioned purpose through the following technical solutions:

[0006] A residual HCD extraction kit using a magnetic bead method comprises a box body and a box cover used in conjunction with the box body, wherein the box body comprises a bottom box and a storage box mounted on the top of the bottom box, wherein the top of the storage box is provided with a plurality of storage slots extending into the bottom box, wherein the interiors of the plurality of storage slots are provided with test tube protection mechanisms, wherein the protection mechanisms comprise a protection tube, an air bag mounted on the inner wall of the protection tube, and a first magnetic block mounted on the bottom of the protection tube, wherein the top of the protection tube is provided with a plurality of air inlet holes, wherein the bottom ends of the plurality of air inlet holes are connected to the air bag via an air inlet pipe, wherein an inflation mechanism for inflating the air bag is mounted on the box cover, and wherein a lifting mechanism for driving the plurality of protection mechanisms to be lifted and lowered is mounted inside the bottom box.

[0007] As a further optimization scheme of the present invention, the inflation mechanism includes a mounting groove opened on the top of the box cover, an inflation box installed in the mounting groove, a foot-operated inflation pump installed on the top of the inflation box and connected to the inflation box through a connecting pipe, and multiple groups of inflation components arranged at the bottom of the box cover.

[0008] As a further optimization solution of the present invention, the inflation assembly includes a plurality of inflation tubes installed at the bottom of the box cover and extending into the inflation box and used in conjunction with the plurality of air inlet holes.

[0009] As a further optimization scheme of the present invention, the lifting mechanism includes a lifting plate located in the bottom box, a plurality of lifting columns installed on the top of the lifting plate and respectively located in a plurality of storage slots, a second magnetic block installed on the top of the lifting column and used in conjunction with the first magnetic block, and lifting components installed on both sides of the lifting plate.

[0010] As a further optimization scheme of the present invention, the lifting assembly includes a movable plate installed on one side of the lifting plate and extending to the outside of the bottom box, a card plate hinged on the top of the movable plate, and a plurality of card slots opened on the outside of the storage box and used in conjunction with the card plate. A movable slot is opened on one side of the bottom box to facilitate the movement of the movable plate.

[0011] As a further optimization solution of the present invention, both sides of the box cover are equipped with locks, and both sides of the storage box are equipped with tongues for use with multiple locks.

[0012] The beneficial effect of the present invention is that during use, the airbag can be inflated through the inflation mechanism, and the airbag will swell, so that the test tube can be wrapped. This not only fixes the test tube, but also reduces the pressure on the test tube because the airbag has a certain anti-deformation ability, thereby reducing the possibility of test tube rupture during transportation. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 is a first three-dimensional structural schematic diagram of the present invention;

[0014] Figure 2 is a second three-dimensional structural schematic diagram of the present invention;

[0015] Figure 3 It is a partial cross-sectional structural schematic diagram of the present invention;

[0016] Figure 4 It is a structural schematic diagram of the protection mechanism of the present invention;

[0017] Figure 5 The present invention Figure 1 Enlarged view of point A in the middle;

[0018] Figure 6 The present invention Figure 2 Enlarged view of point B in the middle;

[0019] Figure 7 The present invention Figure 4 Enlarged view of point C in the middle.

[0020] In the figure: 1. bottom box; 2. storage box; 3. box cover; 4. inflation box; 5. foot-operated inflation pump; 6. latch; 7. latch tongue; 8. clamping plate; 9. movable slot; 10. air inlet pipe; 11. latch slot; 12. movable plate; 13. lifting plate; 14. lifting column; 15. protective tube; 16. first magnetic block; 17. second magnetic block; 18. storage slot; 19. air bag; 20. inflation pipe; 21. air inlet hole. DETAILED DESCRIPTION

[0021] The present application is further described in detail below in conjunction with the accompanying drawings. It is necessary to point out here that the following specific implementation methods are only used to further illustrate the present application and cannot be understood as limiting the scope of protection of the present application. Technical personnel in this field can make some non-essential improvements and adjustments to the present application based on the above application content.

[0022] Example 1

[0023] like Figure 1 - Figure 7 As shown, a residual HCD extraction kit using a magnetic bead method comprises a box body and a box cover 3 used in conjunction with the box body, the box body comprises a bottom box 1, and a storage box 2 installed on the top of the bottom box 1, a plurality of storage slots 18 extending into the bottom box 1 are provided on the top of the storage box 2, a test tube protection mechanism is provided inside each of the plurality of storage slots 18, the protection mechanism comprises a protection tube 15 used in conjunction with the storage box 18, an air bag 19 installed on the inner wall of the protection tube 15, and a first magnetic block 16 installed at the bottom of the protection tube 15, a plurality of air inlet holes 21 are provided on the top of the protection tube 15, the bottom ends of the plurality of air inlet holes 21 are connected to the air bag 19 through an air inlet pipe 10, an inflation mechanism for inflating the air bag 19 is installed on the box cover 3, the inflation mechanism comprises a mounting slot provided on the top of the box cover 3, an inflation box 4 installed in the mounting slot, a foot-operated inflation pump 5 installed on the top of the inflation box 4 and connected to the inflation box 4 through a connecting pipe, and a first magnetic block 16 provided on the bottom of the box cover 3. There are multiple groups of inflatable components at the bottom of the cover 3, and the foot-operated inflatable pump 5 is a common inflatable mechanism in the prior art, and the air inlet and exhaust ports of the foot-operated inflatable pump 5 are both equipped with single-phase valves. When the leather bag is loosened, the inlet one-way valve is opened to inhale air, and the exhaust one-way valve is closed. When the leather bag is compressed, the inlet one-way valve is closed, and the exhaust one-way valve is opened to exhaust air. The inflatable component includes a plurality of inflatable tubes 20 installed at the bottom of the box cover 3 and extending into the inflatable box 4 and used in conjunction with the plurality of air inlet holes 21. The top of the protective tube 15 is made of rubber material, so that when the inflatable tube 20 enters and exits the interior of the air inlet hole 21, an effective sealing effect can be produced to reduce the air leakage between the inflatable tube 20 and the air inlet hole 21. Locks 6 are installed on both sides of the box cover 3, and tongues 7 used in conjunction with multiple locks 6 are installed on both sides of the storage box 2. The locks 6 and tongues 7 are locking components for the electric tricycle compartment, and a plurality of notches used in conjunction with test tubes are provided at the bottom of the box cover 3.

[0024] It should be noted that, when using this magnetic bead method residual HCD extraction kit, the test tube can be placed inside the protective tube 15. After the test tube is placed, the box cover 3 can be covered on the top of the box body. After the box cover 3 is covered, the multiple inflation tubes 20 will move to the multiple air inlet holes 21 respectively, and then the lock 6 will be stuck on the tongue 7 to fix the box cover 3 to the box body. Then, the foot-operated inflation pump 5 is continuously pressed, and the external gas will continuously enter the interior of the inflation box 4. The gas entering the inflation box 4 will enter the multiple air bags 19 through the multiple connecting tubes under the action of the multiple air inlet tubes 20. At this time, the air bags 19 will swell, so that the test tubes can be wrapped. In this way, the test tubes can be effectively protected during transportation to reduce the possibility of test tubes being broken due to shaking.

[0025] like Figure 1 - Figure 7 As shown, the difference between this embodiment and embodiment 1 is that: a lifting plate 13 is provided inside the bottom box 1 pair, and a plurality of lifting columns 14 are installed on the top of the lifting plate 13, and the plurality of lifting columns 14 are respectively located in a plurality of storage slots 18, and a second magnetic block 17 used in conjunction with the first magnetic block 16 is installed on the top of the lifting column 14, and the protective tube 15 and the lifting column 14 can be fixed by the first magnetic block 16 and the second magnetic block 17, and a movable plate 12 with one side extending to the outside of the bottom box 1 is installed on both sides of the lifting plate 13, and a card plate 8 is hinged on the top of the two movable plates 12, and a plurality of card slots 11 used in conjunction with the card plate 8 are provided on both sides of the outside of the storage box 2, and a movable slot 9 for facilitating the movement of the two movable plates 12 is provided on both sides of the bottom box 1.

[0026] The further improved feature of this embodiment is that when the protective mechanism needs to be replaced, the movable plate 12 can be pulled upwards, and the lifting plate 13 will drive the multiple lifting columns 14 to move upwards. Under the push of the lifting columns 14, the multiple protective tubes 15 will move upwards, thereby pushing the protective tubes 15 out from the inside of the storage slot 18. At this time, the protective tubes 15 can be directly removed, so that it is convenient to replace the protective tubes 15. In this way, the test kit can be recycled, thereby saving resources. In addition, when the test tube breaks, it is also convenient for the staff to clean the protective tubes 15, which is more convenient for people to use.

[0027] The above-mentioned embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the present invention. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention.

Claims

1. A magnetic bead method residual HCD extraction kit, comprising a box body and a box cover (3) used in conjunction with the box body, characterized in that: The box body comprises a bottom box (1) and a storage box (2) mounted on the top of the bottom box (1); the top of the storage box (2) is provided with a plurality of storage slots (18) extending into the bottom box (1); the interiors of the plurality of storage slots (18) are provided with test tube protection mechanisms; the protection mechanisms comprise a protection tube (15), an air bag (19) mounted on the inner wall of the protection tube (15), and a first magnetic block (16) mounted on the bottom of the protection tube (15); the top of the protection tube (15) is provided with a plurality of air inlet holes (21); the bottom ends of the plurality of air inlet holes (21) are connected to the air bag (19) through an air inlet pipe (10); an inflation mechanism for inflating the air bag (19) is mounted on the box cover (3); and a lifting mechanism for driving the plurality of protection mechanisms to be lifted and lowered is mounted inside the bottom box (1).

2. A magnetic bead method residual HCD extraction kit according to claim 1, characterized in that: The inflation mechanism comprises a mounting groove provided on the top of the box cover (3), an inflation box (4) installed in the mounting groove, a foot-operated inflation pump (5) installed on the top of the inflation box (4) and connected to the inflation box (4) via a connecting pipe, and a plurality of inflation components arranged on the bottom of the box cover (3).

3. A magnetic bead method residual HCD extraction kit according to claim 2, characterized in that: The inflation assembly comprises a plurality of inflation tubes (20) which are mounted on the bottom of the box cover (3), extend into the inflation box (4) and cooperate with the plurality of air inlet holes (21).

4. A magnetic bead method residual HCD extraction kit according to claim 1, characterized in that: The lifting mechanism comprises a lifting plate (13) located in the bottom box (1), a plurality of lifting columns (14) mounted on the top of the lifting plate (13) and respectively located in a plurality of storage slots (18), a second magnetic block (17) mounted on the top of the lifting column (14) and used in conjunction with a first magnetic block (16), and lifting components mounted on both sides of the lifting plate (13).

5. A magnetic bead method residual HCD extraction kit according to claim 4, characterized in that: The lifting assembly comprises a movable plate (12) mounted on one side of a lifting plate (13) and extending to the outside of the bottom box (1), a card plate (8) hinged on the top of the movable plate (12), and a plurality of card slots (11) provided on the outside of the storage box (2) and used in conjunction with the card plate (8); a movable slot (9) is provided on one side of the bottom box (1) to facilitate the movement of the movable plate (12).

6. A magnetic bead method residual HCD extraction kit according to claim 1, characterized in that: Both sides of the box cover (3) are equipped with latches (6), and both sides of the storage box (2) are equipped with latch tongues (7) for use with the latches (6).

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