Traditional Chinese medicine composition for palpitation and preparation method thereof

Abstract

The invention belongs to the field of medicines, and particularly relates to a traditional Chinese medicine composition for palpitation and a preparation method thereof. Each dose of the traditional Chinese medicine composition comprises the following components by weight: 5-20 g of bighead atractylodes rhizome, 5-15 g of astragalus membranaceus, 5-15 g of ginger, 5-20 g of codonopsis pilosula, 5-15 g of radix ophiopogonis, 5-15 g of cassia twig, 15-25 g of radix rehmanniae, 5-20 g of honey-fried licorice root, 5-20 g of jujube, 3-7 g of vinegar schisandra chinensis, 5-15 g of semen boitae, 5-15 g of scorched hawthorn fruit, 5-15 g of mangnolia officinalis, 5-15 g of fructus alpiniae oxyphyllae, 10-20 g of fructus amomi and 10-20 g of roasted malt. Through organic compatibility, the components jointly play the effects of tonifying qi and blood, stabilizing the mind and the like, comprehensively regulate the immunity of the body, have the effects of nourishing yin and blood, tonifying qi, warming yang, restoring the pulse and setting palpitation, are mainly used for treating palpitation caused by deficiency of yin and blood and deficiency of qi and yin, and have a remarkable treatment effect.

Description

Technical Field

[0001] The invention belongs to the field of medicine, and particularly relates to a traditional Chinese medicine composition for palpitations and a preparation method thereof. Background Art

[0002] Palpitation is a feeling of discomfort or panic in the conscious heartbeat. When the heart rate speeds up, the heartbeat feels uncomfortable, and when the heart rate slows down, the heartbeat feels strong. When palpitations occur, the heart rate can be fast or slow, and there may be arrhythmias. People with normal heart rate and rhythm may also have palpitations. Because there are many causes of palpitations, clinically they are generally caused by emotional fluctuations or fatigue. Therefore, in daily life, it is prudent to use over-the-counter drugs for proper conditioning, improve physical fitness, and enhance the body's immunity, which has a significant effect on the prevention and treatment of palpitations. Therefore, providing a conditioning medicine that is suitable for patients with palpitations to take on a daily basis has positive clinical significance. Summary of the invention

[0003] The invention provides a traditional Chinese medicine composition for palpitations and a preparation method thereof, which can effectively prevent and treat palpitations and can be used for daily conditioning of patients with palpitations.

[0004] The technical solution of the present invention is achieved in this way:

[0005] A traditional Chinese medicine composition for palpitations, each dose comprising the following components by weight: 5-20g of Atractylodes macrocephala, 5-15g of Astragalus, 5-15g of ginger, 5-20g of Codonopsis pilosula, 5-15g of Ophiopogon japonicus, 5-15g of Cinnamomum cassia, 15-25g of Rehmannia glutinosa, 5-20g of Radix Glycyrrhizae Preparata, 5-20g of Jujube, 3-7g of Schisandra chinensis vine with vinegar, 5-15g of Platycladus orientalis, 5-15g of Charred Crataegus pinnatifida, 5-15g of Magnolia officinalis, 5-15g of Alpinia oxyphylla, 10-20g of Amomum villosum, and 10-20g of roasted malt.

[0006] Further, a Chinese medicine composition for palpitations comprises the following group of weight numbers: 10g of Atractylodes macrocephala, 10g of Astragalus, 10g of ginger, 10g of Codonopsis pilosula, 10g of Ophiopogon japonicus, 10g of cinnamon twig, 20g of Rehmannia glutinosa, 10g of roasted Licorice root, 10g of jujube, 5g of Schisandra chinensis 5g, 10g of Platycladus orientalis, 10g of charred Crataegus pinnatifida, 10g of Magnolia officinalis, 10g of Alpinia oxyphylla, 15g of Amomum villosum, and 15g of roasted malt.

[0007] A method for preparing a traditional Chinese medicine composition for palpitations comprises the following steps:

[0008] Take the prescribed amount of Atractylodes macrocephala, Astragalus membranaceus, ginger, Codonopsis pilosula, Ophiopogon japonicus, cinnamon twig, Rehmannia glutinosa, roasted licorice, jujube, vinegar Schisandra chinensis, cypress seed, charred hawthorn, Magnolia officinalis, Alpinia oxyphylla, Amomum villosum, and fried malt, add water and boil, and take the filtrate.

[0009] Furthermore, the amount of water added should be enough to cover the medicinal materials by 3-5 cm.

[0010] Furthermore, the decoction time is 30-40 minutes, and the decoction is performed 2-3 times.

[0011] Application of the above-mentioned Chinese medicine composition in preparing a preparation for treating palpitations.

[0012] Application of the above-mentioned Chinese medicine composition in the preparation of a preparation for improving anti-fatigue ability.

[0013] Furthermore, in the application, the Chinese medicine composition is taken as one dose per day, divided into two doses, each dose being 1 / 2 dose.

[0014] A preparation for treating palpitations, comprising the above Chinese medicine composition.

[0015] Beneficial effects of the present invention:

[0016] The Chinese medicine composition of the present invention has various components that are organically compatible. In the prescription, raw Rehmannia root is used as the main ingredient to nourish yin and blood. The "Famous Doctors' Records" states that Rehmannia root "replenishes the deficiency of internal injuries of the five internal organs, unclogs the blood vessels, and strengthens the qi and strength". The combination of roasted licorice, Codonopsis pilosula, jujube, Atractylodes macrocephala, and Astragalus membranaceus can benefit the heart qi and spleen qi, so as to provide the source of qi and blood biochemical transformation; Ophiopogon japonicus and Schisandra chinensis nourish the heart yin, nourish the heart blood, and replenish the blood vessels, which are all ministerial drugs. Cinnamon twig and ginger are used to warm and circulate, warm the heart yang, and unclog the blood vessels. Platycladus orientalis nourishes the heart, calms the mind, and calms palpitations. Scorched hawthorn, Magnolia officinalis, Amomum villosum, and fried malt promote qi and unclog the blood vessels, harmonize the stomach and digest food, and all heavy and greasy products are nourishing but not greasy. Alpinia oxyphylla warms the spleen and kidney, can warm and unclog the blood vessels of the spleen and kidney, and promote the medicinal power of qi and blood biochemical transformation. At the same time, it can communicate the heart and kidney, so it is a guiding drug. The above components are organically matched to work together to replenish qi and blood, stabilize the mind, comprehensively regulate the body's immunity, have the effects of nourishing yin and blood, invigorating qi and warming yang, restoring pulse and calming palpitations, and are mainly used to treat palpitations caused by insufficient yin and blood, and deficiency of qi and yin, with significant therapeutic effect. DETAILED DESCRIPTION

[0017] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0018] Example 1

[0019] A traditional Chinese medicine composition for palpitations, each dose comprising the following components by weight: 10g of Atractylodes macrocephala, 10g of Astragalus, 10g of ginger, 10g of Codonopsis pilosula, 10g of Ophiopogon japonicus, 10g of Cinnamon twig, 20g of Rehmannia glutinosa, 10g of Radix Glycyrrhizae Preparata, 10g of Jujube, 5g of Schisandra chinensis with vinegar, 10g of Platycladus orientalis seed, 10g of Charred Crataegus pinnatifida, 10g of Magnolia officinalis, 10g of Alpinia oxyphylla seed, 15g of Amomum villosum, and 15g of roasted malt.

[0020] A method for preparing a traditional Chinese medicine composition for palpitations comprises the following steps:

[0021] Take the formulated amount of Atractylodes macrocephala, Astragalus membranaceus, ginger, Codonopsis pilosula, Ophiopogon japonicus, cinnamon twig, Rehmannia glutinosa, roasted licorice, jujube, vinegar Schisandra chinensis, Platycladus orientalis, charred hawthorn, Magnolia officinalis, Alpinia oxyphylla, Amomum villosum, and fried malt, add water to cover the medicinal materials by 3-5 cm and boil for 30-40 minutes, boil 2-3 times, and take the filtrate.

[0022] Example 2

[0023] A traditional Chinese medicine composition for palpitations, each dose comprising the following components by weight: 5g of Atractylodes macrocephala, 5g of Astragalus, 5g of ginger, 5g of Codonopsis pilosula, 5g of Ophiopogon japonicus, 5g of Cinnamomum cassia, 15g of Rehmannia glutinosa, 5g of Radix Glycyrrhizae Preparata, 5g of Jujube, 3g of Schisandrae Chinensis Fruit with Vinegar, 5g of Platycladus Semen, 5g of Charred Crataegus pinnatifida, 5g of Magnolia officinalis, 5g of Alpinia oxyphylla, 10g of Amomum villosum, and 10g of roasted malt.

[0024] A method for preparing a traditional Chinese medicine composition for palpitations comprises the following steps:

[0025] Take the formulated amount of Atractylodes macrocephala, Astragalus membranaceus, ginger, Codonopsis pilosula, Ophiopogon japonicus, cinnamon twig, Rehmannia glutinosa, roasted licorice, jujube, vinegar Schisandra chinensis, Platycladus orientalis, charred hawthorn, Magnolia officinalis, Alpinia oxyphylla, Amomum villosum, and fried malt, add water to cover the medicinal materials by 3-5 cm and boil for 30-40 minutes, boil 2-3 times, and take the filtrate.

[0026] Example 3

[0027] A traditional Chinese medicine composition for palpitations, each dose comprising the following components by weight: 20g of Atractylodes macrocephala, 15g of Astragalus, 15g of ginger, 20g of Codonopsis pilosula, 15g of Ophiopogon japonicus, 15g of Cinnamomum cassia, 25g of Rehmannia glutinosa, 20g of Radix Glycyrrhizae Preparata, 20g of Jujube, 7g of Schisandra chinensis with vinegar, 15g of Platycladus orientalis, 15g of Charred Crataegus pinnatifida, 15g of Magnolia officinalis, 15g of Alpinia oxyphylla, 20g of Amomum villosum, and 20g of roasted malt.

[0028] A method for preparing a traditional Chinese medicine composition for palpitations comprises the following steps:

[0029] Take the formulated amount of Atractylodes macrocephala, Astragalus membranaceus, ginger, Codonopsis pilosula, Ophiopogon japonicus, cinnamon twig, Rehmannia glutinosa, roasted licorice, jujube, vinegar Schisandra chinensis, Platycladus orientalis, charred hawthorn, Magnolia officinalis, Alpinia oxyphylla, Amomum villosum, and fried malt, add water to cover the medicinal materials by 3-5 cm and boil for 30-40 minutes, boil 2-3 times, and take the filtrate.

[0030] (I) In vitro efficacy study

[0031] Since fatigue is an important factor leading to palpitations, the improvement of fatigue resistance can effectively avoid the occurrence of palpitations. And exercise endurance can directly reflect fatigue resistance. The present invention uses a mouse swimming experiment to examine the difference in fatigue resistance of mice with different formulations and evaluate the difference in efficacy of different formulations.

[0032] SPF grade Kunming mice, weighing 20-22g, were randomly divided into groups for the experiment, with 6 mice in each group, half male and half female, and gavage was administered at a dosage of 10ml / kg, 3 times a day. The experiment was divided into an experimental group, a control group and a blank group. The experimental groups were given the Chinese medicine compositions prepared in the three embodiments respectively. The control group prepared the medicinal solution according to the method of Example 1, and the medicinal materials were combined according to the following compatibility. The blank group was given an equal amount of physiological saline to the medicinal solution. All mice were uniformly raised and fed freely.

[0033] Comparative Example 1: Atractylodes macrocephala 10g, Astragalus membranaceus 10g, ginger 10g, Codonopsis pilosula 10g, Ophiopogon japonicus 10g, cinnamon twig 10g, Rehmannia glutinosa 20g, roasted Licorice root 10g, jujube 10g, vinegar Schisandra chinensis 5g, Platycladus orientalis seed 10g, Magnolia officinalis 10g.

[0034] Comparative Example 2: 10g of Atractylodes macrocephala, 10g of Astragalus, 10g of ginger, 10g of Codonopsis pilosula, 10g of Ophiopogon japonicus, 10g of cinnamon twig, 20g of Rehmannia glutinosa, 10g of roasted Licorice root, 10g of jujube, 5g of Schisandra chinensis with vinegar, 10g of Torreya grandis seed, 10g of Magnolia officinalis, 15g of Amomum villosum, and 15g of roasted malt.

[0035] Comparative Example 3: 10g of Atractylodes macrocephala, 10g of Astragalus, 10g of ginger, 10g of Codonopsis pilosula, 10g of Ophiopogon japonicus, 10g of cinnamon twig, 20g of Rehmannia glutinosa, 10g of roasted Licorice root, 10g of jujube, 5g of Schisandra chinensis with vinegar, 10g of Torreya grandis seed, 10g of Magnolia officinalis, 10g of charred Crataegus pinnatifida, and 10g of Alpinia oxyphylla seed.

[0036] All mice were gavaged for 10 days and 30 minutes after the last gavage, and then a swimming test was performed. The mice were weighed and a lead sheet was tied to the base of the tail according to 5% of their body weight. The water temperature of the swimming box was 25°C and the water depth was 40 cm. The mice were placed in the swimming box to swim, and the time from the start of swimming to death was recorded. The results are shown in Table 1.

[0037] Table 1 Effects of different prescriptions on the swimming time of mice

[0038] Treatment Swimming time (min) Example 1 140.1 Example 2 137.2 Example 3 139.5 Comparative Example 1 110.6 Comparative Example 2 123.3 Comparative Example 3 112.8 Blank Group 105.3

[0039] As can be seen from Table 1, compared with the blank group, the swimming time of mice in the embodiment group and the comparative example group was improved to varying degrees, indicating that the anti-fatigue ability of mice can be improved by intragastric administration of the Chinese medicine composition of the embodiment group and the comparative example group. The swimming time of mice in the embodiment group was improved more significantly than that of the comparative example group, indicating that the Chinese medicine composition of the present invention can significantly improve the anti-fatigue ability of experimental mice, effectively prevent palpitations, and significantly improve the efficacy.

[0040] (II) Clinical efficacy study

[0041] Using the "Guidelines for Clinical Research of New Chinese Medicines (Trial)" as the diagnostic criteria, 120 patients with palpitations who visited the First Affiliated Hospital of Hainan Medical College were included in the study and randomly divided into 3 implementation groups and a control group (Western medicine treatment), with 30 cases in each group. There was no statistically significant difference in gender, age, and course of disease between the two groups (P>0.05), and they were comparable. This study was approved by the Ethics Committee of Hainan Medical College, and the patients and their families signed the informed consent.

[0042] The embodiment group was treated with the Chinese medicine composition prepared in Examples 1-3, one dose per day, and the decoction was taken orally, with 1 / 2 dose taken each time. A course of treatment was 7 days, and the longest course of treatment was 5 courses, and the treatment effect was statistically analyzed. The control group was given corresponding Western medicine for symptomatic treatment according to the symptoms. Smoking and drinking were prohibited during the treatment. Recurrence was visited one month after the completion of treatment.

[0043] Table 2 Clinical efficacy of the Chinese medicine composition of the present invention

[0044]

[0045] As can be seen from Table 2, the total effective rate of the present invention can reach more than 90%, and the cure rate can reach more than 43%, which are significantly higher than the control group. The recurrence rate of the 1-month follow-up visit, the number of relapses in the control group was 6, and there were 3, 2 and 2 relapses in the 3 embodiments, which were significantly lower than the control group. Therefore, relative to the control group, the total effective rate and cure rate of the 3 embodiments of the present invention are significantly improved, and the relapse rate is significantly reduced, indicating that the Chinese medicine composition of the present invention has a significant therapeutic effect on palpitations.

[0046] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A Chinese medicine composition for palpitations, characterized in that: Each dose includes the following components by weight: Atractylodes macrocephala 5-20g, Astragalus membranaceus 5-15g, Ginger 5-15g, Codonopsis pilosula 5-20g, Ophiopogon japonicus 5-15g, Cinnamon twig 5-15g, Rehmannia glutinosa 15-25g, Radix Glycyrrhizae uralensis 5-20g, Jujube 5-20g, Schisandra chinensis 3-7g, Torreya grandis seed 5-15g, Charred Crataegus pinnatifida 5-15g, Magnolia officinalis 5-15g, Alpinia oxyphylla seed 5-15g, Amomum villosum 10-20g, and roasted malt 10-20g.

2. A Chinese medicine composition for palpitations as claimed in claim 1, characterized in that: The group includes the following weight numbers: 10g of Atractylodes macrocephala, 10g of Astragalus, 10g of ginger, 10g of Codonopsis pilosula, 10g of Ophiopogon japonicus, 10g of cinnamon twig, 20g of Rehmannia glutinosa, 10g of roasted Licorice root, 10g of jujube, 5g of Schisandra chinensis with vinegar, 10g of Platycladus orientalis, 10g of charred Crataegus pinnatifida, 10g of Magnolia officinalis, 10g of Alpinia oxyphylla, 15g of Amomum villosum, and 15g of roasted malt.

3. A method for preparing a Chinese medicine composition for palpitations as claimed in claim 1 or 2, characterized in that: The following steps are involved: Take the prescribed amount of Atractylodes macrocephala, Astragalus membranaceus, ginger, Codonopsis pilosula, Ophiopogon japonicus, cinnamon twig, Rehmannia glutinosa, roasted licorice, jujube, vinegar Schisandra chinensis, cypress seed, charred hawthorn, Magnolia officinalis, Alpinia oxyphylla, Amomum villosum, and fried malt, add water and boil, and take the filtrate.

4. The preparation method according to claim 3, characterized in that: The amount of water added should be enough to cover the medicinal materials by 3-5 cm.

5. The preparation method according to claim 3, characterized in that: The decoction time is 30-40 minutes, and decoction is 2-3 times.

6. Use of a traditional Chinese medicine composition for palpitations as claimed in claim 1 or 2 in the preparation of a preparation for treating palpitations.

7. Use of a traditional Chinese medicine composition for palpitations as claimed in claim 1 or 2 in the preparation of a preparation for improving fatigue resistance.

8. The use according to claim 6 or 7, characterized in that The Chinese medicine composition is taken once a day, divided into two doses, each dose being 1 / 2 dose.

9. A preparation for treating palpitations, characterized in that: Including the Chinese medicine composition according to claim 1 or 2.

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