Preparation with antibacterial and anti-inflammatory effects

Abstract

The invention discloses an antibacterial and anti-inflammatory preparation. The preparation at least contains an antibacterial component and a non-antibiotic non-glucocorticoid anti-inflammatory component. The antibacterial component is a component containing effective iodine, and the non-antibiotic non-glucocorticoid anti-inflammatory component is one or a combination of glycyrrhizic acid compounds. When the preparation is used, the effective iodine contained in the preparation plays a bactericidal role, meanwhile, the glycyrrhizic acid compound plays an anti-inflammatory role to prevent inflammation expansion and shorten the duration time of inflammation, the sterilization and anti-inflammatory functions can be achieved at the same time when the preparation is sprayed on a wound surface, and the sterilization effect of the preparation is higher than that of some traditional Chinese medicines; and the use limitation and side effects of glucocorticoid anti-inflammatory preparations are avoided. Compared with the prior art, the preparation provided by the invention can improve the treatment efficiency of wound infection.

Description

Technical Field

[0003] The invention belongs to the field of infection treatment preparations, and in particular relates to a preparation with antibacterial and anti-inflammatory effects. Background Art

[0005] After the skin and mucous membranes are infected with bacteria and viruses, topical and oral Chinese medicine or chemical preparations have been widely used by clinical practitioners as an important and effective means of treatment. Among many infections, the most common infection is the infection of the oropharyngeal mucosa after a cold. Its symptoms are mainly dryness, pain, itching and cough in the oropharynx. Common clinical treatment methods: In the early stage of pharyngeal infection treatment, watermelon frost lozenges, ice penicillin powder, Kaihoujian spray, goldenrod spray, honeysuckle lozenges, isatis root granules, Pudilan oral liquid, blue scutellaria oral liquid and other sprays, lozenges, and granules are often used for treatment. However, as the infection process continues, the symptoms of some patients will worsen, and fever, pharyngeal suppuration, and obvious exudation will occur. At this time, it is necessary to confirm the type of bacterial infection according to the test and then take oral antibiotics such as amoxicillin and cephalosporin for treatment. If it is confirmed to be a viral infection, antiviral drugs should be used appropriately or wait for self-healing. When the symptoms of a very small number of patients develop to severe levels, dexamethasone and other glucocorticoids should be taken orally or infused to control the progression of inflammation.

[0006] Looking at the various Chinese herbal preparations used in the early stage of treatment, many studies have confirmed that the Chinese herbal medicines contained in them, such as Glauber's salt, borax, honeysuckle, isatis root, dandelion, Viola yedoensis, Octopus japonicus, Sophora flavescens, Solidago asiatica, Scutellaria baicalensis, Cyperus rotundus, Forsythia suspensa, etc., have certain antibacterial, antibacterial and antiviral effects, which play a certain role in treatment, but their antibacterial, antibacterial and antiviral effects are relatively weak; and the antibiotics and hormone anti-inflammatory drugs used in the process of infection from aggravation to severity also need to have clear indications for use during the treatment process, and there are limitations on their use, such as: the anti-inflammatory effect of antibiotics is by killing It blocks the progression of inflammation through bacterial action, but is usually ineffective against viruses. It should generally be used when there is fever, suppuration, or obvious exudation, and its use requires the support of test results and drug sensitivity results to avoid the indiscriminate use of antibiotics causing bacterial resistance; viral strains mutate quickly, and chemical antiviral drugs have a poor broad-spectrum effect. Traditional Chinese medicine with antiviral effects is usually used, and its effect is relatively weak; glucocorticoids are only used in patients with severe symptoms, and their use has more precautions: before use, gastric ulcers, tuberculosis, femoral head necrosis, severe hypertension, diabetes and other hormone contraindications must be ruled out before hormone drugs can be used for treatment.

[0007] That is to say, the problem of low bactericidal efficiency of the drugs used in the early stage of treatment exists, and no other anti-inflammatory preparations are used to treat the infection from the early stage of infection to the aggravated stage. As the disease progresses, some patients will not see a doctor until their symptoms worsen to determine whether it is a bacterial infection and determine which sensitive drugs to use. Most patients with viral infections need to wait for the pharyngeal infection to heal itself, and anti-inflammatory treatments such as glucocorticoids are only used as treatment drugs for patients with severe symptoms, and are intervened late or not at all. Given that the use of antibiotic anti-inflammatory preparations and glucocorticoids requires clear indications, and considering that the abuse of antibiotics should be avoided, if safe anti-inflammatory preparations can be used as soon as possible while improving the bactericidal efficiency, the infection and the symptoms caused by the infection can be relieved more quickly. Therefore, it is a clinical problem to seek a non-antibiotic, non-glucocorticoid anti-inflammatory preparation that has a high bactericidal efficiency against both bacteria and viruses, is safe and reliable, and can intervene in inflammation treatment earlier. Summary of the invention

[0009] The technical problem to be solved by the present invention is to develop a preparation for the problem that the sterilization efficiency of bacteria and viruses is low during the clinical treatment of skin and mucous membrane infections, and non-antibiotic and non-glucocorticoid anti-inflammatory preparations are intervened late or not at all during the treatment process. To solve this problem, a preparation with antibacterial and anti-inflammatory effects is provided, which contains antibacterial ingredients and non-antibiotic and non-glucocorticoid anti-inflammatory ingredients, and can achieve a high killing efficiency for bacteria and viruses during clinical treatment, while achieving the purpose of early intervention of non-antibiotic and non-glucocorticoid anti-inflammatory treatment.

[0010] To solve this problem, the technical solution adopted by the present invention is as follows: a preparation with antibacterial and anti-inflammatory effects contains antibacterial ingredients and non-antibiotic non-glucocorticoid anti-inflammatory ingredients.

[0011] The antibacterial component in a preparation with antibacterial and anti-inflammatory effects is a preparation component containing an effective iodine component. An effective iodine component refers to a preparation component that uses iodine (including elemental iodine, iodine ions, iodine complexes, organic iodine, etc.) as an antibacterial component. The principle of effective iodine sterilization is mainly that the iodine in the iodine preparation oxidizes the active groups of pathogen proteins and combines with the amino groups of the pathogens, thereby denaturing the amino acids and enzymes of the pathogens and achieving the purpose of sterilization. Common preparations in life are iodine tincture, iodine wine, and compound iodine-containing disinfectants.

[0012] Non-antibiotic non-glucocorticoid anti-inflammatory ingredients refer to other preparation ingredients that do not use antibiotics to kill bacteria and viruses as anti-inflammatory treatment and do not use glucocorticoids as anti-inflammatory ingredients. In addition to antibiotic anti-inflammatory ingredients, the most common is glucocorticoid anti-inflammatory ingredients, which can help eliminate inflammatory reactions and inhibit inflammation, thereby preventing the spread of inflammation and eliminating various symptoms caused by inflammation, thereby achieving the purpose of treating infection. Anti-inflammatory pathways are usually achieved: 1. Inhibit the migration of granulocytes and macrophages outside blood vessels and reduce inflammatory invasive tissue reactions. 2. Inhibit the recruitment of neutrophils, monocytes and macrophages to inflammatory sites. 3. Inhibit inflammatory capillary dilation, reduce the permeability of capillary walls and the formation of edema. 4. Stabilize lysosomal membranes to reduce the release of hydrolases in lysosomes, thereby reducing damage to tissues. However, because glucocorticoids have many side effects, they cannot be used when there is no indication for use in the early stage of infection. Therefore, seeking a component with glucocorticoid anti-inflammatory properties and no glucocorticoid side effects, and not constrained by the indication for use, is the anti-inflammatory component condition to be selected by the present invention.

[0013] A non-antibiotic non-glucocorticoid anti-inflammatory ingredient in a preparation with antibacterial and anti-inflammatory effects is a glycyrrhizic acid compound. Glycyrrhizic acid compounds are a general term for glycyrrhizic acid, glycyrrhizic acid glycosides, and glycyrrhizic acid salts, including: glycyrrhizic acid, ammonium glycyrrhizinate, diammonium glycyrrhizinate, glycyrrhizic acid glycosides, potassium glycyrrhizinate, sodium glycyrrhizinate, and magnesium glycyrrhizinate. Glycyrrhizic acid compounds have anti-inflammatory effects similar to glucocorticoids, among which glycyrrhizic acid is the most representative, which has a strong anti-inflammatory effect and can inhibit inflammatory reactions. The anti-inflammatory mechanism of glycyrrhizic acid is: inhibiting the metabolic levels of phospholipase A2 / arachidonic acid (PLA2 / AA), NF-κB and MAPK / AP-1 key inflammatory response signals induced by inflammatory stimulation at the initial stage, inhibiting the activity of inflammatory response signals related to the three inflammatory pathways, down-regulating the expression of pro-inflammatory cytokines related to the upstream of the inflammatory pathway, including TNF-α, IL-8, IL-1β, IIL-6, related chemokines and cyclooxygenase (COX), and blocking the downstream of the inflammatory pathway, including the generation of nitric oxide (NO), prostaglandins (PG) and reactive oxygen species (ROS). In other words, glycyrrhizic acid can play a good inhibitory role in the further development and expansion of inflammatory diseases, and glycyrrhizic acid does not have some side effects and indications of glucocorticoids, and can be used as a non-antibiotic anti-inflammatory preparation for early application to the site of infection.

[0014] A preparation with antibacterial and anti-inflammatory effects contains antibacterial ingredients and non-antibiotic non-glucocorticoid anti-inflammatory ingredients. In addition to being used on the oropharyngeal mucosa, it can also be applied to other skin mucosa sites. It can still play a bactericidal role and early intervention role in non-antibiotic anti-inflammatory treatment during the treatment process.

[0015] In summary, when using a preparation with antibacterial and anti-inflammatory effects, the effective iodine contained in it exerts a bactericidal effect while the glycyrrhizic acid compound exerts an anti-inflammatory effect to prevent the expansion of inflammation and shorten the duration of inflammation. Spraying on the wound surface can simultaneously achieve the functions of bactericidal and anti-inflammatory. Its bactericidal effect is more efficient than some traditional Chinese medicines, and there are no restrictions and side effects on the use of glucocorticoid anti-inflammatory preparations. Compared with existing treatment technologies, this preparation can improve the treatment efficiency of wound infection. DETAILED DESCRIPTION

[0017] The embodiments of the present invention include but are not limited to the following:

[0018] 1. Take 500ml of purified water, add 3g of glycyrrhizic acid (HPLC 70%) into the water, heat and stir until completely dissolved, take another 500ml of purified water, slowly add 100g of povidone iodine powder and stir, wait until the temperature of the glycyrrhizic acid solution drops to room temperature, add the glycyrrhizic acid solution into the povidone iodine solution and stir evenly, and the preparation containing povidone iodine and glycyrrhizic acid is obtained. The test items and effects are as follows: the killing rate of Staphylococcus aureus, Escherichia coli, and Candida albicans is ≥90% (suspension quantitative method, 2 minutes of action); glycyrrhizic acid content is 0.2% (w / v).

Claims

1. A preparation having antibacterial and anti-inflammatory effects, characterized in that: The preparation contains at least an antibacterial component and a non-antibiotic non-glucocorticoid anti-inflammatory component.

2. The preparation having antibacterial and anti-inflammatory effects according to claim 1, characterized in that: The antibacterial component is a preparation component containing an effective iodine component.

3. The preparation with antibacterial and anti-inflammatory effects according to claim 1, characterized in that: The non-antibiotic and non-glucocorticoid anti-inflammatory component is one or a combination of glycyrrhizic acid compounds.