Implantable nerve acquisition and stimulation system, physiological electric signal transmission method and storage medium

Abstract

The invention belongs to the technical field of implantable medical instruments, and particularly relates to an implantable nerve acquisition and stimulation system, a physiological electric signal transmission method and a storage medium. The implantable nerve acquisition and stimulation system comprises a main controller; the plurality of sub-controllers are respectively and electrically connected with the main controller in a wired manner through connecting wires; the plurality of acquisition stimulation units are electrically connected with the corresponding sub-controllers in a wired manner; wherein the sub-controller is provided with a first circuit assembly, and the first circuit assembly comprises a digital-to-analog conversion circuit and an analog-to-digital conversion circuit. The analog-to-digital conversion circuit converts multiple analog electric signals acquired by the acquisition stimulation unit into at least one digital electric signal and transmits the digital electric signal to the main controller through a connecting line; or the digital-to-analog conversion circuit converts the stimulation digital electric signals into multi-path analog electric signals through the sub-controller and transmits the multi-path analog electric signals to the acquisition stimulation unit. The main controller and the sub-controller carry out labor division processing on multiple paths of analog electric signals, so that the energy consumption and heating of the main controller can be reduced, and the number of channels can be increased.

Description

Technical Field

[0001] The present invention belongs to the technical field of implantable medical devices, and in particular relates to an implantable neural acquisition and stimulation system, a method for transmitting physiological electrical signals, and a storage medium. Background Art

[0002] Implantable neuromodulation products are limited by factors such as implant volume, power consumption, and packaging process, resulting in a low number of channels, which can no longer meet the acquisition and stimulation needs in the field of neuromodulation. Since the implant is generally encapsulated in a titanium shell, with a battery and a charging coupling coil inside, and metal on the coupling path, increasing the number of channels will not only lead to a larger implant volume and poor sealing, but also increase the power of the processor, affecting the difficulty of implantation and postoperative life. Therefore, how to solve the problems of high throughput and sealing has always been a technical problem for implantable neuromodulation products.

[0003] For example, patent number CN118402799A discloses a neural interface device, an electrode preparation method, and a device replacement method. In the specification, it is disclosed that the first conductive contact of the first feedthrough is electrically connected to the neural signal circuit inside the implantable housing, and then the contact portion of the proximal end of the electrode is electrically connected to the first conductive contact of the first feedthrough through an interposer connector, thereby taking into account both detachability and sealing. The interposer connector 400 includes a matrix and an array of conductive contacts that penetrate the matrix. For example, the interposer connector 400 can be an ACF film (anisotropic conductive film), an LGA connector (LandGrid Array Connector, grid array packaging connector), or other two-dimensional dot matrix connectors with first and second surfaces. The interposer connector 400 is used for electrical interconnection between the proximal contact portion 310 of the flexible neural electrode 300 of high-throughput nerves and the electronic device 1. Obviously, this technical solution ignores the amount of channels occupied by analog electrical signals, resulting in limited increase in the number of channels. It mainly solves the sealing problem during the detachable process, as stated in paragraphs 0144-0145 of the specification, "Furthermore, when the original implantable housing is removed, the original neural electrode is not removed. Furthermore, when the proximal contact portion of the flexible neural electrode is connected to the first feedthrough sheet of the new implantable housing, a detachable connection method is adopted. The proximal contact portion of the flexible neural electrode is consistent with the contact of the new implantable housing, and the positioning pin can also match the proximal structure of the flexible neural electrode, so that the electrode can be directly connected to the new implantable housing; when it is necessary to replace the implantable housing, the pressure cover can be opened, which is very convenient to separate the flexible neural electrode from the implantable housing." Summary of the invention

[0004] The present invention provides an implantable neural acquisition and stimulation system, a method for transmitting physiological electrical signals, and a storage medium, which realizes digital-to-analog or analog-to-digital conversion of electrical signals during transmission by means of division of labor processing of multi-channel analog electrical signals by main and sub-controllers.

[0005] In order to solve the above technical problems, the present invention provides an implantable neural acquisition and stimulation system, comprising: a main controller; a plurality of sub-controllers, which are respectively electrically connected to the main controller by connecting wires; a plurality of acquisition and stimulation units, which are electrically connected to the corresponding sub-controllers by connecting wires; wherein the sub-controllers are provided with a first circuit component, including a digital-to-analog conversion circuit and an analog-to-digital conversion circuit.

[0006] Furthermore, the sub-controller includes: a first shell, which is assembled into a first closed space by a first outer shell, a first feedthrough flange, and a second outer shell; wherein the first circuit component is located in the first closed space and between the first feedthrough flange and the second outer shell; the first feedthrough flange includes a flange plate, on which a first feedthrough area and a second feedthrough area are arranged; both sides of the first feedthrough area are electrically connected to the collection stimulation unit and the first circuit component respectively; and both sides of the second feedthrough area are electrically connected to the first circuit component and the connecting line respectively.

[0007] Furthermore, the collection stimulation unit includes: an electrode sheet, on which a plurality of electrode contacts are arranged; a sheet lead, which protrudes from the side of the electrode sheet and extends to be inserted into the first closed space; and a lead matrix, which is located at the end of the sheet lead and is electrically connected to each electrode contact one by one through a conductive circuit.

[0008] Furthermore, the first circuit component also includes: a first circuit board, a first connection point matrix and a second connection point matrix respectively located on the first circuit board; the lead point matrix is ​​electrically connected to the first connection point matrix; the connecting line is electrically connected to the second connection point matrix; the digital-to-analog conversion circuit and the analog-to-digital conversion circuit are respectively arranged on the first circuit board.

[0009] Furthermore, a plurality of pads are provided on the first feedthrough area, and two ends of the pads are electrically connected to the first connection point matrix and the lead point matrix respectively; a plurality of first feed pins are provided on the second feedthrough area, and two ends of the pads are electrically connected to the second connection point matrix and the connection line respectively.

[0010] Furthermore, a notch is provided on a side surface of the first housing for inserting the sheet lead into the first closed space.

[0011] Furthermore, the main controller includes: a second shell with an opening on the side; a second circuit component, which is placed inside the second shell through the opening; a second feedthrough flange, which covers the opening to form a second closed space; wherein the two sides of the second feedthrough flange are electrically connected to the second circuit component and the connecting wire respectively.

[0012] Furthermore, the second feedthrough flange includes: a feedthrough cover covering the opening; a conductive ring array located on the outside of the feedthrough cover; a third feedthrough area arranged on the feedthrough cover; and a plurality of second feed pins are arranged on the third feedthrough area, and two ends of the second feed pins are respectively electrically connected to the second circuit component and the conductive ring array.

[0013] Furthermore, the conductive ring array is in the shape of a rod, a first conductive ring electrically connected to the second feed pin is arranged on its side, and a plug hole electrically connected to the connecting wire is arranged at its end.

[0014] Furthermore, the connecting line is configured as a multi-channel concentric cable; one end of the multi-channel concentric cable is connected to the first feed pin, and the other end is provided with a second conductive ring electrically connected to the plug hole.

[0015] Furthermore, the second circuit assembly includes: a second circuit board; an in-body coil arranged on one side of the second circuit board; and a magnetic isolation sheet located on the other side of the second circuit board, wherein a placement hole for accommodating the internal magnet is opened in the middle thereof.

[0016] In the second aspect, the present invention provides a method for transmitting physiological electrical signals, including: when performing an acquisition task, using a plurality of acquisition stimulation units to respectively acquire multiple analog electrical signals and transmit them to corresponding sub-controllers, the sub-controllers convert the multiple analog electrical signals into at least one digital electrical signal and transmit them to the main controller via a connecting line, the main controller transmits the digital electrical signal to an external processor via coil coupling and / or detects and processes the digital electrical signal; when performing a stimulation task, the main controller transmits the digital electrical signal to the corresponding sub-controller via a connecting line using a stimulation instruction, the sub-controller converts the digital electrical signal into multiple analog electrical signals and transmits them to the acquisition stimulation unit, and the acquisition stimulation unit sends an electrical stimulation signal to the tissue.

[0017] In a third aspect, the present invention provides a computer-readable storage medium having a computer program stored thereon, wherein the computer program implements the steps of the transmission method when executed by a processor.

[0018] The beneficial effects of the present invention are that the implantable neural acquisition and stimulation system, the transmission method of physiological electrical signals, and the storage medium of the present invention connect the sub-controller to the main controller by wire, and the acquisition and stimulation unit to the corresponding sub-controller by wire. During the signal transmission process, the sub-controller first converts the multi-channel analog electrical signals collected by the acquisition and stimulation unit into at least one digital electrical signal, which can reduce the number of channels occupied, and then transmits the digital electrical signal to the main controller through the connecting line, which is analyzed and processed by the main controller or transmitted to the external machine, thereby avoiding excessive occupation of the number of channels by the analog electrical signal during the signal transmission process, and while ensuring that the volume of the implant remains unchanged, more channels can be vacated for the acquisition electrode. In addition, the sub-controller near the target point converts the analog signal into a digital signal and transmits it to the main controller, which can also achieve efficient and accurate data acquisition conversion and transmission, and avoid signal distortion during long-distance transmission.

[0019] Other features and advantages of the present invention will be described in the following description, and partly become apparent from the description, or understood by practicing the present invention. The purpose and other advantages of the present invention are realized and obtained by the structures particularly pointed out in the description, claims and drawings.

[0020] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, preferred embodiments are given below and described in detail with reference to the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the specific implementation methods of the present invention or the technical solutions in the prior art, the drawings required for use in the specific implementation methods or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some implementation methods of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0022] Figure 1 It is a schematic diagram of the structure of an implantable neural acquisition and stimulation system.

[0023] Figure 2 It is a principle block diagram of an implantable neural acquisition and stimulation system.

[0024] Figure 3 It is a schematic diagram of the exploded structure of the sub-controller.

[0025] Figure 4 It is a cross-sectional view of the sub-controller.

[0026] Figure 5 Schematic diagram of the structure of the first feed-through flange.

[0027] Figure 6 is a schematic structural diagram of a first circuit component.

[0028] Figure 7 It is a schematic diagram of the main controller's exploded structure.

[0029] Figure 8 It is a structural diagram of the main controller.

[0030] In the figure:

[0031] Main controller 1, second housing 11, third metal connector 111, second circuit assembly 12, second circuit board 121, in-body coil 122, magnetic isolation sheet 123, placement hole 1231, inner magnet 124, second feedthrough flange 13, feedthrough cover 131, conductive ring array 132, first conductive ring 1321, plug hole 1322, third feedthrough area 133, second protective layer 14;

[0032] Sub-controller 2, first housing 21, first shell 211, notch 2111, first feedthrough flange 212, flange 2121, first feedthrough area 2122, second feedthrough area 2123, first metal connector 2124, second metal connector 2125, second shell 213, first circuit assembly 22, first circuit board 221, second connection matrix 222, first protective layer 23;

[0033] Connecting wire 3, second conductive ring 31;

[0034] Collection stimulation unit 4, electrode sheet 41, electrode contact 411, sheet lead 42, lead array 43. DETAILED DESCRIPTION

[0035] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution of the present invention will be clearly and completely described below in conjunction with the accompanying drawings. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0036] Example 1

[0037] Since analog electrical signals need to form a one-to-one relationship with the acquisition channel to be used for signal analysis, and implants are limited by surgery and long-term use requirements, there are strict restrictions on the power consumption and heat generation of the processor, and they cannot process signals from a large number of channels at the same time, so high-throughput implants cannot be formed. Figure 1-Figure 8As shown, this embodiment 1 provides an implantable neural acquisition stimulation system, including: a main controller 1; a plurality of sub-controllers 2, which are respectively connected to the main controller 1 by connecting lines 3; a plurality of acquisition stimulation units 4, which are connected to the corresponding sub-controllers 2 by wires; the sub-controllers 2 are provided with a first circuit component 22, including a digital-to-analog conversion circuit and an analog-to-digital conversion circuit.

[0038] Specifically, the sub-controller 2 is used to convert the multiple analog electrical signals collected by the collection stimulation unit 4 into at least one digital electrical signal and transmit it to the main controller 1 through the connecting line 3; or the main controller 1 is used to convert the stimulation digital electrical signal into multiple analog electrical signals through the sub-controller 2 and transmit it to the collection stimulation unit 4. The process is as follows: Figure 2 , the connection mode between the internal machine and the external machine is that the main controller obtains energy and transmits data through wireless coupling between the internal coil and the external coil; the connection relationship between the components of the internal machine is that the main controller is connected to the sub-controller through a connecting line, supplies energy to the sub-controller and transmits data; the sub-controller is connected to the acquisition stimulation unit through a connecting line, supplies energy to the acquisition stimulation unit and transmits data. The specific working process is as follows: when performing the acquisition task, each acquisition stimulation unit or electrode sheet transmits the collected multi-channel analog electrical signals to the sub-controller, the sub-controller converts the multi-channel analog electrical signals into at least one digital electrical signal and transmits it to the main controller through a multi-channel concentric cable, the main controller transmits the digital electrical signal to the outside of the body through coil coupling, or the main controller does not need to transmit the digital electrical signal, and performs detection or stimulation processing on the digital electrical signal according to the machine training or the set threshold parameters. On the contrary, when performing the stimulation task, the main controller makes a stimulation instruction according to the machine training or the set threshold parameters, and transmits the digital electrical signal to the corresponding sub-controller through the connecting line, and the sub-controller converts the digital electrical signal into a multi-channel analog electrical signal and transmits it to the acquisition stimulation unit, and the acquisition stimulation unit sends an electrical stimulation signal to the tissue. Obviously, the main controller receives or sends digital electrical signals; the sub-controller, as an intermediary between the collection and stimulation unit and the main controller, is responsible for the digital-to-analog or analog-to-digital conversion of the electrical signal. In this process, the main controller is responsible for coupling with the external machine, obtaining electrical energy and supplying energy to the sub-controller and the collection and stimulation unit, which significantly reduces the energy consumption and power limitation of the main controller, and also avoids the distortion of the electrical signal during transmission. However, compared with the prior art, a sub-controller is added, and thereby the connection seal between the sub-controller and the collection and stimulation unit, and the connection seal between the sub-controller and the main controller are increased, and the number of circuits at both ends of the sub-controller is different, resulting in a special structural design for its connection method to meet the one-to-one circuit connection and sealing requirements. The specific connection relationship and technical solution are as follows:

[0039] As an optional implementation of the acquisition stimulation unit.

[0040] See Figure 3 The collection stimulation unit 4 includes: an electrode sheet 41, on which a plurality of electrode contacts 411 are arranged; a sheet lead 42, which protrudes from the side of the electrode sheet 41 and extends to be inserted into the interior of the sub-controller 2; a lead matrix 43, which is located at the end of the sheet lead 42 and is electrically connected to each electrode contact 411 through a conductive circuit.

[0041] Optionally, the acquisition stimulation unit 4 can be provided in plurality as needed, and form a one-to-one correspondence with the sub-controller 2, so as to realize the digital-to-analog conversion of the stimulation electrical signal from the main controller via the sub-controller to the acquisition stimulation unit, or realize the analog-to-digital conversion of the acquisition signal from the acquisition stimulation unit via the sub-controller to the main controller.

[0042] As an optional implementation of the sub-controller.

[0043] See Figure 3 , Figure 4 , Figure 5 The sub-controller 2 includes: a first shell 21, which is assembled into a first closed space by a first shell 211, a first feedthrough flange 212, and a second shell 213; wherein the first circuit component 22 is located between the first feedthrough flange 211 and the second shell 213; the first feedthrough flange 212 includes a flange plate 2121, on which a first feedthrough area 2122 and a second feedthrough area 2123 are arranged; the two sides of the first feedthrough area 2122 are respectively electrically connected to the collection stimulation unit 4 and the first circuit component 22; the two sides of the second feedthrough area 2123 are respectively electrically connected to the first circuit component 22 and the connecting line 3.

[0044] Optional, see Figure 6 The first circuit assembly 22 includes: a first circuit board 221, a first connection matrix and a second connection matrix 222 respectively located on the first circuit board 221; wherein the lead matrix 43 is electrically connected to the first circuit board 221 through the first connection matrix; the connecting wire 3 is electrically connected to the first circuit board 221 through the second connection matrix 222; the digital-to-analog conversion circuit and the analog-to-digital conversion circuit are respectively arranged on the first circuit board 221. The specific structure is as follows: Figure 3 and Figure 4 The side of the first housing 211 is provided with a notch 2111 for inserting the sheet lead 42 into the first closed space, that is, the sheet lead 42 is located between the flange 2121 and the first housing 211, and the lead matrix 43 on the sheet lead 42 can be welded to the pad end of the first feedthrough area 2122. Figure 5The first feedthrough flange 212 is configured as a flange 2121 made of metal, and the first feedthrough area 2122 and the second feedthrough area 2123 thereon are both ceramic bodies, which are welded to the flange 2121 by ceramic metallization, that is, two through holes are first opened inside the metal flange 2121, and metal connectors are welded at the through holes, and then the first feedthrough area 2122 and the first metal connector 2124 are brazed together, and the second feedthrough area 2123 and the second metal connector 2125 are brazed together. The first feedthrough area 2122 is provided with a plurality of pads, and the two ends thereof are respectively electrically connected to the first connection dot matrix and the lead dot matrix 43 in a point-to-point correspondence; the second feedthrough area 2123 is provided with a plurality of first feed pins, and the two ends thereof protrude from the two sides of the flange 2121, and are respectively electrically connected to the second connection dot matrix 222 in a point-to-point correspondence, and are respectively electrically connected to the multiple routes of the connection line 3 in a point-to-point correspondence, thereby forming an electrical connection path of the collection stimulation unit-sub-controller (in which the digital-to-analog conversion or analog-to-digital conversion of the electrical signal is realized)-connection line-main controller, so that the first circuit component can realize the conversion of digital electrical signals to analog signals when performing the electrical stimulation function, and realize the conversion of analog signals to digital electrical signals when performing the collection task. In particular, the electrode sheet and the first circuit board are connected by directly aligning the dot matrix to the dot matrix at the first end of the sub-controller, which is conducive to the transmission and sealing of the analog electrical signal, and the connection method of the dot matrix to the multi-channel coaxial cable is adopted at the second end of the sub-controller, which is conducive to reducing the number of channels occupied by the digital electrical signal. Obviously, the number of pads (ie, the number of channels) is significantly greater than the number of first feed pins.

[0045] Optionally, the first circuit board is configured as, for example but not limited to, an FPGA development board, and the FPGA development board directly controls multiple analog sub-cards, including an ADC chip (i.e., an analog-to-digital conversion circuit), a DAC chip (i.e., a digital-to-analog conversion circuit) and peripheral circuits; the FPGA development board is configured as a signal generator as a control chip of a sub-controller. When performing the electrical stimulation function, a stimulation waveform can be generated according to the stimulation protocol sent by the main controller and transmitted to the DAC chip, and the DAC chip converts the stimulation waveform (digital signal) into an electrical stimulation signal (analog signal) and sends it to the corresponding acquisition stimulation unit. When performing the signal acquisition task, the ADC chip converts the electrophysiological signal (analog signal) collected by the acquisition stimulation unit into a digital electrical signal (digital signal) and uploads it to the main controller. The above-mentioned mutual conversion function of analog signals to digital electrical signals and its implementation circuit belong to the prior art, and this application does not make substantial improvements to it.

[0046] Optional, see Figure 4, with the two sides of the first feed-through flange 212 or the flange 2121 as the boundary, the first housing 211 is assembled on the upper side, and the second housing 213 is assembled on the lower side. The first housing 211 is a metal part, and a rib is provided on the lower circumference of the first housing 211 to form an assembly relationship with the upper circumference of the flange 2121. A notch is provided on the rib for the sheet lead 42 to be inserted into the first closed space; the lower circumference of the flange 2121 is provided with a rib to form an assembly relationship with the second housing 213, thereby assembling the first housing 211, the first feed-through flange 212, and the second housing 213 into a first closed space, which is divided into an upper and lower part by the first feed-through flange 212 as the boundary, the upper part is inserted with the sheet lead 42, and the lower part accommodates the first circuit component 22. During processing and assembly, the sheet lead 42 is first inserted into the first closed space, and the lead matrix 43 is electrically connected to the end of the pad by welding or plugging, and the bottom of the pad is electrically connected to the first connection matrix point-to-point (due to the Figure 6 is a bottom view of the first circuit board, and the pad is located on the top of the first circuit board, and the first connection point matrix is ​​also located on the top surface of the first circuit board. Figure 6 The dot matrix arrangement diagram is not visible in the figure), since the first connection dot matrix and the second connection dot matrix 222 are electrically connected through the first circuit board 221, and then the second connection dot matrix 222 is electrically connected to the bottom of the first feed needle, and the top of the first feed needle is electrically connected to the multi-path of the connecting line 3, the above electrical connection methods can all be welding methods, and then the first shell 211 is covered on the top of the first feed-through flange 212, and the second shell 213 is covered on the bottom of the first feed-through flange 212 to form the first closed space, and the side parts of which are respectively led out to the collection stimulation unit 4 and the connecting line 3, and finally the first protective layer 23, such as injection-molded silicone, is wrapped on the outside of the sub-controller 2, thereby realizing the electrical connection and sealed assembly between the collection stimulation unit and the sub-controller.

[0047] As an optional implementation of the main controller.

[0048] See Figure 7 and Figure 8 The main controller 1 includes: a second shell 11 with an opening on the side; a second circuit component 12, which is disposed inside the second shell 11 through the opening; a second feedthrough flange 13, which covers the opening to form a second closed space; wherein the two sides of the second feedthrough flange 13 are electrically connected to the second circuit component 12 and the connecting line 3 respectively.

[0049] Optionally, the second shell is formed of a ceramic material, and an end of the second shell is brazed with a third metal connector 111 and then welded to the feed-through cover 131 to form a second closed space.

[0050] Optional, see Figure 7 and Figure 8The second feed-through flange 13 includes: a feed-through cover 131, covering the opening; a conductive ring array 132, located on the outside of the feed-through cover 131; a third feed-through area 133, arranged on the feed-through cover 131; a plurality of second feed pins are arranged on the third feed-through area 133, and both ends of the second feed pins protrude from both sides of the feed-through cover 131, and are electrically connected to the second circuit component 12 and the conductive ring array 132 respectively.

[0051] Optional, see Figure 8 , the conductive ring array 132 is in the shape of a rod, and a first conductive ring 1321 electrically connected to the second feed pin is provided on its side, and a plug hole 1322 electrically connected to the connecting line 3 is provided at its end. The connecting line 3 is configured as a multi-channel concentric cable; the first end of the multi-channel concentric cable is connected to the first feed pin, and the second end is provided with a second conductive ring 31 electrically connected to the plug hole 1322. When the connecting line 3 is inserted into the plug hole 1322, the second conductive ring 31 contacts the first conductive ring 1321 to form a one-to-one circuit connection. Therefore, the number of first conductive rings 1321 can be multiple, the same as the number of acquisition units 4 or sub-controllers 2, and each first conductive ring 1321 is independently arranged and electrically insulated to avoid electrical signal interference between different acquisition units 4. The second protective layer 44 can also be wrapped around the outer side of the main controller 1 as a whole.

[0052] Optional, see Figure 7 The second circuit component 12 includes: a second circuit board 121, located inside the second closed space; an in-vivo coil 122, arranged on one side of the second circuit board 121. In order to reduce the occupied space, the in-vivo coil 122 can be directly printed on the second circuit board 121, and through coupling with the external coil, it can supply energy or transmit signals to the in-vivo device; a magnetic isolation sheet 123, located on the other side of the second circuit board 121, and a placement hole 1231 for accommodating the internal magnet 124 is opened in the middle thereof.

[0053] In this case, the preparation method of the implantable neural collection and stimulation system includes: preparing a main controller, a sub-controller, and a collection and stimulation unit respectively; connecting the collection and stimulation units to the corresponding sub-controllers one by one by wires; and connecting each sub-controller to the main controller by connecting wires. The specific process is as follows:

[0054] (1) Preparation of the collection stimulation unit: making a bottom silicone sheet as an electrode sheet; bonding a metal sheet to the bottom silicone sheet, laser cutting the metal sheet to form electrode contacts at the distal end of the electrode sheet and a lead matrix at the proximal end, and making the metal sheet between the two form a conductive circuit; spin coating an upper silicone sheet, laser cutting the upper silicone sheet to expose the electrode contacts and the lead matrix.

[0055] (2) Preparing the main controller includes: connecting the in-body coil to the second circuit component, and installing the magnetic isolation sheet and the internal magnet; welding the second circuit component to the second feed pin on the second feed-through flange and then installing it into the second shell; welding and encapsulating the second feed-through flange to the second shell; welding the second feed pin on the feed-through cover to the first conductive ring; and performing overall injection molding to form a second protective layer.

[0056] (3) preparing a sub-controller, including: welding the first connection point matrix and the second connection point matrix on the first circuit component to the solder pad and the first feed pin on the first feed-through flange respectively; welding the first shell and the first feed-through flange to encapsulate; welding the lead matrix and the first end of the connecting wire to the solder pad and the first feed pin on the first feed-through flange respectively; welding the second shell and the first feed-through flange; and integrally injecting the first protective layer.

[0057] (4) Connecting each sub-controller to the main controller via a connecting wire includes: inserting the second conductive ring at the second end of the connecting wire into the plug hole of the first conductive ring to achieve electrical connection between the connecting wire and the conductive ring array; and installing each conductive ring array into an insulating sleeve, arranging and injection molding.

[0058] In summary, the main controller and sub-controller of the implantable neural acquisition stimulation system of the present embodiment 1 respectively perform different tasks, and can share power consumption and heat. Through the coupling of the internal coil and the external coil, both energy supply and signal transmission can be realized. There is no metal on the coupling path, and no eddy current heat generation. The volume of the electronic device in the body can be further reduced, and the safety of the electronic device in the body can be improved. It can also support higher internal circuit power consumption and realize more functions such as closed-loop processing. In particular, it can support implantable acquisition stimulation equipment with wireless power supply transmission, and does not require batteries. At the same time, with the help of the electrical signal conversion between the acquisition stimulation unit, the sub-controller and the main controller, the sub-controller is used as the transfer center of analog electrical signals and digital electrical signals, which can avoid the circuit number requirement of the analog electrical signal in the transmission process, and can also realize the requirement of the digital electrical signal to perform the stimulation task, and can realize efficient and accurate data acquisition conversion and transmission. With the help of high-density ceramic feedthrough, more channels can be added, the volume is smaller, and the cost is lower, resulting in a smaller volume of the main controller or sub-controller, which is conducive to surgical implantation.

[0059] Example 2

[0060] On the basis of Example 1, this Example 2 provides a method for transmitting physiological electrical signals, including: when performing an acquisition task, using a plurality of acquisition stimulation units to respectively acquire multiple analog electrical signals and transmit them to corresponding sub-controllers, the sub-controllers convert the multiple analog electrical signals into at least one digital electrical signal and transmit them to the main controller via a connecting line, the main controller transmits the digital electrical signal to an external processor via coil coupling and / or performs detection and processing on the digital electrical signal; when performing a stimulation task, the main controller transmits the digital electrical signal from the stimulation instruction to the corresponding sub-controller via a connecting line, the sub-controller converts the digital electrical signal into multiple analog electrical signals and transmits them to the acquisition stimulation unit, and the acquisition stimulation unit sends an electrical stimulation signal to the tissue.

[0061] Example 3

[0062] On the basis of Embodiment 1, this Embodiment 3 provides a computer-readable storage medium on which a computer program is stored. When the computer program is executed by a processor, the steps of the transmission method are implemented.

[0063] In the description of the embodiments of the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0064] In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", and "third" are used for descriptive purposes only, and cannot be understood as indicating or implying relative importance.

[0065] In the several embodiments provided in this application, it should be understood that the disclosed systems, devices and methods can be implemented in other ways. The device embodiments described above are only schematic. For example, the division of the units is only a logical function division. There may be other division methods in actual implementation. For example, multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed.

[0066] Based on the above ideal embodiments of the present invention, the relevant staff can make various changes and modifications without departing from the technical concept of the present invention through the above description. The technical scope of the present invention is not limited to the contents of the specification, and its technical scope must be determined according to the scope of the claims.

Claims

1. An implantable neural collection and stimulation system, characterized in that: include: Main controller; Several sub-controllers are electrically connected to the main controller via connecting wires; A plurality of collection and stimulation units are electrically connected to corresponding sub-controllers by wires; in The sub-controller is provided with a first circuit component, including a digital-to-analog conversion circuit and an analog-to-digital conversion circuit.

2. The implantable neural collection and stimulation system according to claim 1, characterized in that: The sub-controller also includes: The first housing is composed of a first outer shell, a first feed-through flange, and a second outer shell assembled into a first closed space; The first circuit assembly is located in the first enclosed space and between the first feed-through flange and the second housing; The first feedthrough flange comprises a flange plate, on which a first feedthrough area and a second feedthrough area are arranged; The two sides of the first feedthrough area are electrically connected to the collection stimulation unit and the first circuit component respectively; Two sides of the second feedthrough region are electrically connected to the first circuit component and the connecting line respectively.

3. The implantable neural collection and stimulation system according to claim 2, characterized in that: The collection stimulation unit comprises: An electrode sheet having a plurality of electrode contacts disposed thereon; A sheet lead protrudes from a side of the electrode sheet and extends to be inserted into the first closed space; The lead matrix is ​​located at the end of the sheet lead and is electrically connected to each electrode contact point through a conductive circuit in a one-to-one correspondence.

4. The implantable neural collection and stimulation system according to claim 3, characterized in that: The first circuit assembly further comprises: A first circuit board and a first connection point matrix and a second connection point matrix respectively located on the first circuit board; wherein The lead matrix is ​​electrically connected to the first connection matrix; The connecting wire is electrically connected to the second connecting point matrix; The digital-to-analog conversion circuit and the analog-to-digital conversion circuit are respectively arranged on the first circuit board.

5. The implantable neural collection and stimulation system according to claim 4, characterized in that: A plurality of pads are provided on the first feedthrough area, and two ends of the pads are electrically connected to the first connection dot matrix and the lead dot matrix respectively; A plurality of first feed pins are arranged on the second feed-through area, and two ends of the first feed pins are electrically connected to the second connection point matrix and the connection line respectively.

6. The implantable neural collection and stimulation system according to claim 3, characterized in that: A notch is provided on the side of the first housing for inserting the sheet lead into the first closed space.

7. The implantable neural collection and stimulation system according to claim 1, characterized in that: The main controller comprises: A second shell having an opening on the side; A second circuit assembly is disposed inside the second housing through the opening; The second feed-through flange covers the opening to form a second closed space; Two sides of the second feed-through flange are electrically connected to the second circuit component and the connecting wire respectively.

8. The implantable neural collection and stimulation system according to claim 1, characterized in that: The second feed-through flange comprises: A feedthrough cover, covering the opening; a conductive ring array located on the outside of the feedthrough cover; A third feedthrough area, disposed on the feedthrough cover; A plurality of second feed pins are arranged on the third feed-through area, and two ends of the second feed pins are electrically connected to the second circuit component and the conductive ring array respectively.

9. The implantable neural collection and stimulation system according to claim 8, characterized in that: The conductive ring array is in the shape of a rod, a first conductive ring electrically connected to the second feed pin is arranged on its side, and a plug hole electrically connected to the connecting wire is arranged on its end.

10. The implantable neural collection and stimulation system according to claim 9, characterized in that: The connecting lines are configured as multi-channel concentric cables; One end of the multi-channel coaxial cable is connected to the first feed pin, and the other end is provided with a second conductive ring electrically connected to the plug hole.

11. The implantable neural collection and stimulation system according to claim 7, characterized in that: The second circuit assembly comprises: a second circuit board; An in-body coil is arranged on one side of the second circuit board; The magnetic isolation sheet is located on the other side of the second circuit board, and a placement hole for accommodating the inner magnet is opened in the middle thereof.

12. A method for transmitting physiological electrical signals, characterized in that: include: When performing the acquisition task, a plurality of acquisition stimulation units are used to respectively acquire multiple analog electrical signals and transmit them to the corresponding sub-controllers, the sub-controllers convert the multiple analog electrical signals into at least one digital electrical signal and transmit them to the main controller via a connecting line, the main controller transmits the digital electrical signal to an external processor via coil coupling and / or performs detection and processing on the digital electrical signal; When performing a stimulation task, the main controller transmits the stimulation instruction to the corresponding sub-controller via a connecting line in the form of a digital electrical signal. The sub-controller converts the digital electrical signal into a multi-channel analog electrical signal and transmits it to the acquisition stimulation unit, which sends an electrical stimulation signal to the tissue.

13. A computer-readable storage medium having a computer program stored thereon, characterized in that: When the computer program is executed by a processor, the steps of the transmission method according to claim 12 are implemented.

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