Mosquito repellent containing noottanone as well as preparation method and application of mosquito repellent

Abstract

The invention belongs to the technical field of mosquito repellent, and particularly relates to a noottanone-containing mosquito repellent as well as a preparation method and application thereof. The active substances of the mosquito repellent comprise noottanone and geraniol, the mosquito repellent is prepared from the following components in percentage by mass: 0.1 to 7 percent of noottanone and 0.1 to 1 percent of geraniol. According to the mosquito repellent disclosed by the invention, noottanone is taken as a main mosquito repellent active component, the mosquito repellent effect is remarkable, the protection capability is lasting, and the mosquito repellent time can reach 9 hours or longer; geraniol is added for compounding, it is found that the effective mosquito repelling time is prolonged, synergistic interaction can be achieved, and cost optimization is achieved; meanwhile, the fragrance is richer and has layering sense, and sensory enjoyment and pleasure of a user are greatly improved. The mosquito-repellent incense is simple in production process, stable in formula, free of deet or mosquito repellent grease, safe, non-toxic, harmless to a human body and unique in fragrance, and has an excellent mosquito-repellent effect.

Description

Technical Field

[0001] The invention belongs to the technical field of mosquito repellents, and particularly relates to a mosquito repellent containing grapefruit ketone, and a preparation method and application thereof. Background Art

[0002] As one of the "four pests", mosquitoes are the vectors of many diseases such as malaria, epidemic meningitis, dengue fever and yellow fever. Their potential transmission risks cannot be ignored. Once bitten by a mosquito, most people will experience symptoms of skin redness, swelling, itching and pain, and sometimes even unbearable itching. However, scratching will only aggravate skin irritation, promote the extravasation of tissue fluid and lymph fluid, and make the redness and swelling more severe, falling into a vicious cycle of scratching and itching. For people with allergies, the situation may be even worse. Excessive scratching may cause the redness and swelling to spread and the symptoms to worsen. With the improvement of living standards, modern people pay more and more attention to health, and the concept of preventing mosquito bites and eliminating the spread of diseases has been deeply rooted in the hearts of the people. This change has led to a booming market for mosquito repellent and mosquito repellent products, while consumers' requirements and expectations for products are also rising.

[0003] In daily life, applying repellents is a common strategy to prevent mosquito bites. Repellents can be roughly divided into two categories: chemical synthesis and plant sources. These products can release special odors to keep insects away, providing outdoor activities with a "protective shield" for a period of time to avoid insect infestation. Currently widely used chemical repellents, such as DEET, chlorpyrifos and picaridin, are popular among consumers for their significant mosquito repellent effects and durability. However, the potential harm of these chemical repellents to the human body has gradually surfaced. In particular, DEET has been frequently accused of having side effects on the human body and posing a threat to the environment in recent years. Studies have revealed that DEET can inhibit the activity of acetylcholinesterase in the central nervous system of mammals. In addition, there is a risk of excessive skin absorption in actual application, which may cause symptoms such as urticaria syndrome in children, allergic reactions, and bradycardia. What is more worrying is that when DEET is mixed with carbamate insecticides, its toxicity will increase, posing a serious threat to human health. As the public pays more and more attention to health and environmental protection issues, especially sanitary insecticides are directly used in people's lives and living environments and are in close contact with the human body, people have increasingly stringent requirements on the safety of such products. Based on this, the present invention is proposed. Summary of the invention

[0004] In order to overcome the shortcomings and deficiencies of the prior art, the object of the present invention is to provide a mosquito repellent containing oleocanthal and a preparation method and application thereof.

[0005] The mosquito repellent of the present invention uses oleic acid ketone as the main active mosquito repellent ingredient, has a significant mosquito repellent effect, a long-lasting protective ability, and a mosquito repellent time of more than 9 hours; adding geraniol for compounding, it is found that the effective mosquito repellent time is extended, and synergistic synergy can be achieved to achieve cost optimization; at the same time, the fragrance is more intense and has a sense of hierarchy, which greatly enhances the sensory enjoyment and pleasure of the user. The present invention has a simple production process, a stable formula, does not contain DEET or mosquito repellent, is safe and non-toxic and harmless to the human body, has a unique fragrance, and has an excellent mosquito repellent effect.

[0006] The purpose of the present invention is achieved through the following technical solutions: A mosquito repellent containing oleocanthal, wherein the active substances include oleocanthal and geraniol; the mass percentages of the components in the mosquito repellent are 0.1-7% of oleocanthal and 0.1-1% of geraniol.

[0007] Preferably, among the active substances, the mass percentages of the components in the mosquito repellent are: 0.3-7% of oleic acid ketone and 0.1-1% of geraniol.

[0008] Further preferably, among the active substances, the mass percentages of the components in the mosquito repellent are: 0.3-5% of oleic acid ketone and 0.1-1% of geraniol.

[0009] More preferably, among the active substances, the mass percentages of the components in the mosquito repellent are: 0.3-5% of oleic acid ketone and 0.5±0.1% of geraniol.

[0010] Preferably, the mosquito repellent further comprises the following components in percentage by mass: 2-60% solvent, 0.5-10% dispersant, 0-5% moisturizer, 0-0.5% antibacterial agent, and the remainder water; the total is 100%, calculated as a percentage by mass of the mosquito repellent.

[0011] Grapefruit ketone, also known as nootkatone, is a natural organic compound and the most important and expensive aromatic substance in grapefruit. It has a long-lasting and strong citrus-like fruity aroma, and a typical grapefruit aroma at lower dilutions. Grapefruit ketone in spray form has been proven to be an effective mosquito repellent or insecticide, and can also repel bed bugs, head lice and other insects. In August 2020, the U.S. Environmental Protection Agency (EPA) and the U.S. Centers for Disease Control and Prevention (CDC) officially approved the use of grapefruit ketone as an insecticide (mosquito repellent). Grapefruit ketone has become the sixth active mosquito repellent ingredient recommended by the CDC in recent decades. Compared with other non-natural mosquito repellent compounds, grapefruit ketone has the advantages of safety, non-toxicity, good mosquito repellent effect and long duration. As a new type of green mosquito repellent ingredient, it has great potential for application and development in personal protective preparations such as portable mosquito repellent water.

[0012] In order to further enhance the mosquito repellent effect of the mosquito repellent and effectively alleviate the current high cost of oleocanthal, the present invention introduces geraniol, which is more affordable, for compound preparation, synergistically enhancing the effect, effectively extending the mosquito repellent time, and achieving cost optimization. In addition, the addition of geraniol also gives the mosquito repellent a richer and more layered aroma, greatly enhancing the user's sensory enjoyment and pleasure, making the mosquito repellent experience more pleasant and memorable.

[0013] The solvent is one or more of ethanol, isopropanol, benzyl alcohol, octanol, isopentanol, 1,2-pentanediol, 1,4-butanediol, isopropyl myristate, diethyl phthalate, butyl phthalate and the like.

[0014] Preferably, the solvent is one or any combination of ethanol, isopropanol and benzyl alcohol; Further preferably, the solvent is a combination of ethanol, isopropanol and benzyl alcohol; Preferably, the mass percentage of the solvent in the mosquito repellent is 8 to 60%; more preferably, it is 21±1%.

[0015] Further preferably, the solvent is a combination of ethanol, isopropanol and benzyl alcohol, and the mass percentage of each component in the mosquito repellent is: ethanol 2-20%, isopropanol 5-30%, benzyl alcohol 1-15%; further preferably, ethanol 5±1%, isopropanol 10±1%, benzyl alcohol 6±1%.

[0016] The dispersant is one or more of polyvinyl pyrrolidone, polyacrylate, polyacrylic acid, polyethylene glycol, polyvinyl alcohol, polyvinyl acetate, polyacrylate carboxylate copolymer, styrene acrylic acid copolymer, alkyl polyglucoside and the like.

[0017] Preferably, the dispersant is polyvinyl pyrrolidone.

[0018] Preferably, the mass percentage of the dispersant in the mosquito repellent is 2±1%.

[0019] The moisturizing agent is one or any combination of glycerin, propylene glycol, sodium hyaluronate, oat protein, glycine, serine, and alanine; Preferably, the humectant is at least one of glycerol and propylene glycol; More preferably, the moisturizing agent is a combination of glycerin and propylene glycol.

[0020] The antibacterial agent is one or any combination of phenoxyethanol, sodium benzoate, 2,4-dichlorobenzyl alcohol, o-cymene-5-ol, benzoic acid, dehydroacetic acid and sodium dehydroacetate; Preferably, the antibacterial agent is at least one of phenoxyethanol, sodium benzoate, 2,4-dichlorobenzyl alcohol and o-cymene-5-ol.

[0021] Preferably, when the moisturizing agent is 1-5% and the antibacterial agent is 0.1-0.3% (more preferably, the moisturizing agent is 5±0.5% and the antibacterial agent is 0.3±0.03%), a mosquito repellent wet wipe liquid containing grapefruit ketone can be prepared, or the mosquito repellent wet wipe liquid and the non-woven fabric carrying the mosquito repellent wet wipe liquid constitute a mosquito repellent wet wipe containing grapefruit ketone.

[0022] Further preferably, when the moisturizer is 1-5% and the antibacterial agent is 0.1-0.3% (more preferably, the moisturizer is 5±0.5% and the antibacterial agent is 0.3±0.03%), the moisturizer is a combination of glycerin and propylene glycol; and the mass percentage of each component in the mosquito repellent is: glycerin 2%, propylene glycol 3%; the antibacterial agent is a combination of phenoxyethanol and sodium benzoate; and the mass percentage of each component in the mosquito repellent is: phenoxyethanol 0.1%, sodium benzoate 0.2%.

[0023] Preferably, when the moisturizer is 0.5-5% and the antibacterial agent is 0.2-0.5% (more preferably, the moisturizer is 3±0.3% and the antibacterial agent is 0.5±0.05%), a mosquito repellent spray for pets containing grapefruit ketone can be prepared.

[0024] Further preferably, when the moisturizer is 0.5-5% and the antibacterial agent is 0.2-0.5% (more preferably, the moisturizer is 3±0.3% and the antibacterial agent is 0.5±0.05%), the moisturizer is a combination of glycerol and propylene glycol; and the mass percentage of each component in the mosquito repellent is: glycerol 1%, propylene glycol 2%; the antibacterial agent is a combination of 2,4-dichlorobenzyl alcohol and o-cymene-5-ol; and the mass percentage of each component in the mosquito repellent is: 2,4-dichlorobenzyl alcohol 0.3%, o-cymene-5-ol 0.2%.

[0025] The present invention also provides a method for preparing a mosquito repellent containing grapefruit ketone, comprising the following steps: dissolving a moisturizer and a dispersant in water according to mass percentage; then sequentially adding a solvent, grapefruit ketone, geraniol and an antibacterial agent, stirring evenly, and filtering to obtain the mosquito repellent.

[0026] In one technical solution, the mosquito repellent is a spray or a coating.

[0027] The present invention also provides a use of a mosquito repellent containing grapefruit ketone in repelling mosquitoes; Preferably, the mosquito repellent containing oleocanthal is used for repelling Aedes mosquitoes; Preferably, the Aedes mosquito includes at least one of Aedes albopictus and Aedes aegypti.

[0028] The application is: spraying or applying the mosquito repellent on the protected area, with a dosage of 1 to 5 mg / cm 2 .

[0029] Compared with the prior art, the present invention has the following advantages and effects: (1) Mosquitoes are important health pests that spread diseases. A concentration of more than 1% of oleocanthal can provide an average of more than 4 hours of protection time, and the protection rate is as high as more than 99%. The higher the content of oleocanthal in the repellent, the longer the protection time can be provided. Therefore, the mosquito repellent of the present invention uses oleocanthal as the main mosquito repellent active substance, has a significant mosquito repellent effect, and has a long-lasting protective ability. It does not contain chemical mosquito repellent ingredients such as DEET or chlorpyrifos, and is green, safe and non-toxic.

[0030] (2) The more affordable geraniol was introduced into the compound formulation. This strategy not only achieved cost optimization, but also greatly extended the effective duration of mosquito repellent through the synergistic effect of the two. In addition, the addition of geraniol also gave the mosquito repellent a richer and more layered fragrance, greatly enhancing the user's sensory enjoyment and pleasure, making the mosquito repellent experience more pleasant and memorable.

[0031] (3) The mosquito repellent of the present invention can also be prepared into mosquito repellent wet wipes, mosquito repellent spray for pets, etc. After using the mosquito repellent wet wipes, there is no discomfort, and the skin feels moisturized, comfortable and non-irritating. The citrus fragrance is long-lasting and rich in layers, which is pleasing to the senses. The mosquito repellent spray for pets can achieve mosquito repelling, insect repelling, and antibacterial effects at the same time. The citrus fragrance is long-lasting, and it can effectively remove pet body odor and other odors, keeping the indoor air fresh. Therefore, the mosquito repellent of the present invention has a good application prospect. DETAILED DESCRIPTION

[0032] The present invention is further described in detail below in conjunction with the embodiments, but the embodiments of the present invention are not limited thereto. The technical scheme of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments; based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0033] Examples 1-4 The components and weight contents of the mosquito repellent containing oleocanthal described in Examples 1-4 are shown in Table 1.

[0034] Table 1 Comparative Examples 1-6 The components and weight contents of the mosquito repellents described in Comparative Examples 1-6 are shown in Table 2.

[0035] Table 2 The above-mentioned mosquito repellent is prepared according to the following method: Dissolve polyvinyl pyrrolidone in water; then add ethanol, isopropanol, benzyl alcohol, oleic acid ketone and geraniol in sequence, stir evenly, and filter to obtain a mosquito repellent containing oleic acid ketone.

[0036] Mosquito repellent effect test The mosquito repellent experiment process this time refers to the relevant standard: GB / T 13917.9-2009 Indoor efficacy test and evaluation of public health insecticides for pesticide registration (Part 9: Repellents).

[0037] (1) Experimental conditions The laboratory environment temperature is 27±2℃, and the humidity is 65±10%. The indoor temperature and humidity are controlled by air conditioning and humidifier.

[0038] (2) Attack power test 500 test insects (Aedes albopictus about 3 days after emergence, with an equal ratio of males and females) were placed in a mosquito cage (30×30×30 cm). 12 volunteers (6 men and 6 women) washed and dried their hands and put on medical latex gloves. A 4cm×4cm notch was cut on the back of the hand, and the rest of the hands were tightly covered. The hands without any samples were placed in the mosquito cage and closely observed. When the mosquito landed on the exposed skin area on the back of the hand for 2 seconds or more, it was recorded as a mosquito attack. Volunteers and test insects with more than 30 mosquito attacks within 2 minutes were considered to have qualified attack power, and this volunteer and this cage of mosquitoes could be used for subsequent repellent experiments.

[0039] (3) Repellent experiment During the experiment, one hand was used as a blank control without any sample; the other hand was sprayed directly on the exposed part of the back of the hand with the mosquito repellent of Examples 1-4 and Comparative Examples 1-6, respectively, with a spraying dose of one pump (about 1-1.2 mL). After air drying, the hand was placed in a mosquito cage to start the test. During the test, the back of each volunteer's hand was placed in the mosquito cage for 2 minutes, and the number of mosquitoes landing on the exposed area was recorded, and then the test was conducted every 1 hour.

[0040] The complete protection was considered to have failed until one mosquito was observed to land or attempt to bite, and the time recorded was the average complete protection time. The experiment was repeated 3 times, and the experimental results were taken as the average of each experiment.

[0041] After the test, the repellency rate (Percentage Repellency) of each repellent is calculated according to the following formula: C refers to the control group, that is, the number of mosquitoes landing when no sample was applied to the back of the hand; T refers to the experimental group, that is, the number of mosquitoes landing after the corresponding sample was applied to the back of the hand.

[0042] Table 3 Complete protection time and 4h and 8h repellency rate of mosquitoes sprayed with different repellents As can be seen from the data in Table 3, the mosquito repellent provided by Examples 1-4 of the present invention exhibits an excellent mosquito repellent effect, and with the increasing content of oleic acid, the effective protection time and repellent rate also show a steady upward trend. It is worth noting that compared with DEET, a powerful mosquito repellent ingredient that is widely recognized at present, the mosquito repellent of the present invention is superior in mosquito repellent effect.

[0043] In addition, it can be seen from Table 3 that the complete protection time of the mosquito repellent after the combination of nutmeg ketone and geraniol on mosquitoes shows an effect of "1+1>2", and the 8h repellency rate also shows an effect of "1+1>2", which belongs to synergistic effect, that is, the complete protection time of Example 1 is longer than the sum of the complete protection time of Comparative Example 2 and Comparative Example 3 acting alone, and the 8h repellency rate of Example 1 is higher than the sum of the 8h repellency rates of Comparative Example 2 and Comparative Example 3 acting alone; similarly, Example 2> Comparative Example 2+Comparative Example 4, Example 3> Comparative Example 2+Comparative Example 5, Example 4> Comparative Example 2+Comparative Example 6, all of which belong to synergistic effect; Examples 1-4 use a combination of nutmeg ketone and geraniol, while Comparative Example 2 and Comparative Examples 3-6 use geraniol and nutmeg ketone as single components, respectively. The repellency effects of the mosquito repellents of Examples 1-4 are all better than those of Comparative Example 2 and Comparative Example 3-6, respectively, indicating that the combined use of nutmeg ketone and geraniol synergizes.

[0044] The final results were evaluated with reference to the national standard of the People's Republic of China "Indoor efficacy evaluation of pesticide registration and hygienic insecticides / repellents GB / T 13917.9-2009", and the efficacy was evaluated according to the effective protection time (h) of the repellent to the test personnel. The efficacy results were divided into two levels, A and B, and those that did not meet the B-level standard were unqualified products (A-level effective protection time ≥6.0h, B-level effective protection time ≥4.0h). It can be seen from the above table that Examples 1-4 of the present invention all meet the qualified standards, among which Examples 1-2 reached B level, and Examples 3-4 reached A level.

[0045] Example 5 This embodiment is an application example of preparing mosquito repellent wet wipes by using the mosquito repellent combination containing grapefruit ketone described in Examples 1-4. A mosquito repellent wet wipes, comprising a mosquito repellent wet wipes liquid and a non-woven fabric carrying the mosquito repellent wet wipes liquid; the mosquito repellent wet wipes liquid comprises the components of the mosquito repellent except water, a moisturizer, an antibacterial agent and water.

[0046] The mosquito repellent containing grapefruit ketone described in Examples 1-4 is used to prepare mosquito repellent wet wipes and wet wipes, comprising the following steps: (1) Prepare the components according to the mosquito repellent wet wipes liquid formulas numbered 1-4 in Preparation Table 4.

[0047] (2) Add the formulated amount of deionized water into a mixing bucket, add glycerin and propylene glycol during the stirring process and mix well, add the components of the mosquito repellent except water, phenoxyethanol, and sodium benzoate into the mixing bucket, stir until evenly mixed, and filter to obtain mosquito repellent wipes liquid.

[0048] (3) Add the prepared mosquito repellent wet wipes liquid and non-woven fabric at a mass ratio of 2.5:1 to the non-woven fabric, and then cut into the required size and package to obtain mosquito repellent wet wipes.

[0049] The mosquito repellent wet wipes and wet wipes No. 1-4 were tested for mosquito repellent effect. The test method of the mosquito repellent effect of this embodiment is the same as that of Embodiments 1-4, but based on the usage of the product, the test process adopts the smearing method. The specific formula and results are shown in Table 4.

[0050] Table 4 After testing, after the test group wiped the mosquito repellent wet wipes, the mosquito repellent protection duration and mosquito repellent rate were similar to those of the mosquito repellents of Examples 1 to 4. After using the mosquito repellent wet wipes, the experimental group members did not feel uncomfortable, and the skin was moisturized, comfortable and non-irritating, and the citrus fragrance was long-lasting and rich in layers, which was pleasing to the senses.

[0051] Example 6 This embodiment is an application example of preparing a mosquito repellent spray for pets by using the mosquito repellent combination containing grapefruit ketone. A mosquito repellent spray for pets is composed of the components of the mosquito repellent except water, a moisturizer and an antibacterial agent.

[0052] The mosquito repellent containing grapefruit ketone described in Examples 1-4 is used to prepare a mosquito repellent spray for pets, comprising the following steps: (1) Prepare the components according to the formulations of pet mosquito repellent spray numbered Ⅰ to Ⅳ in Preparation Table 5.

[0053] (2) Add the formulated amount of deionized water into a mixing bucket, add glycerin and propylene glycol during the stirring process and stir evenly, add the components of the mosquito repellent except water, 2.4-dichlorobenzyl alcohol, and o-cymene-5-ol into the mixing bucket, stir until evenly, and filter to obtain a mosquito repellent spray for pets.

[0054] The mosquito repellent sprays for pets numbered Ⅰ-Ⅳ were tested for mosquito repellent effect. The test method for the mosquito repellent effect of this embodiment is the same as that of embodiments 1-4. The specific formula and results are shown in Table 5.

[0055] Table 5 After testing, the mosquito repellent spray for pets provided by the present invention has a mosquito repellent protection duration and mosquito repellent rate similar to those of the mosquito repellents of Examples 1 to 4. It has a long effective mosquito repellent effect time of more than 8 hours, can achieve mosquito repellent and insect repellent, and inhibit bacteria, and has a long-lasting citrus fragrance, can effectively remove pet body odor and other odors, and keep the indoor air fresh.

[0056] The above embodiments are preferred implementation modes of the present invention, but the implementation modes of the present invention are not limited to the above embodiments. Any other changes, modifications, substitutions, combinations, and simplifications that do not deviate from the spirit and principles of the present invention should be equivalent replacement methods and are included in the protection scope of the present invention.

Claims

1. A mosquito repellent containing grapefruit ketone, characterized in that: Its active substances include: nutmeg ketone and geraniol; the mass percentage of each component in the mosquito repellent is: nutmeg ketone 0.1-7% and geraniol 0.1-1%; Furthermore, among the active substances, the mass percentages of the components in the mosquito repellent are: 0.3-7% of naringenone and 0.1-1% of geraniol; Furthermore, among the active substances, the mass percentages of the components in the mosquito repellent are: 0.3-5% of naringenone and 0.1-1% of geraniol; Furthermore, among the active substances, the mass percentages of the components in the mosquito repellent are: 0.3-5% of oleic acid ketone and 0.5±0.1% of geraniol.

2. The mosquito repellent containing grapefruit ketone according to claim 1, characterized in that: The mosquito repellent further comprises the following components in percentage by mass: 2-60% solvent, 0.5-10% dispersant, 0-5% moisturizer, 0-0.5% antibacterial agent, and the remainder water; the total is 100%, calculated as a percentage by mass of the mosquito repellent.

3. The mosquito repellent containing grapefruit ketone according to claim 2, characterized in that: When the moisturizer is 1-5% and the antibacterial agent is 0.1-0.3%, a mosquito repellent wet wipe liquid containing grapefruit ketone is prepared, or the mosquito repellent wet wipe liquid and the non-woven fabric carrying the mosquito repellent wet wipe liquid form a mosquito repellent wet wipe containing grapefruit ketone; Alternatively, when the moisturizer is 0.5-5% and the antibacterial agent is 0.2-0.5%, a mosquito repellent spray for pets containing oleocanthocyanin can be prepared.

4. The mosquito repellent containing grapefruit ketone according to claim 2, characterized in that: The solvent is one or more of ethanol, isopropanol, benzyl alcohol, octanol, isopentanol, 1,2-pentanediol, 1,4-butanediol, isopropyl myristate, diethyl phthalate, and butyl phthalate; Further, the solvent is one or any combination of ethanol, isopropanol and benzyl alcohol; Still further, the solvent is a combination of ethanol, isopropanol and benzyl alcohol; Furthermore, the solvent is a combination of ethanol, isopropanol and benzyl alcohol, and the mass percentage of each component in the mosquito repellent is: ethanol 2-20%, isopropanol 5-30%, benzyl alcohol 1-15%.

5. The mosquito repellent containing grapefruit ketone according to claim 2, characterized in that: The dispersant is one or more of polyvinyl pyrrolidone, polyacrylate, polyacrylic acid, polyethylene glycol, polyvinyl alcohol, polyvinyl acetate, polyacrylate carboxylate copolymer, styrene acrylic copolymer, and alkyl polyglucoside; further, the dispersant is polyvinyl pyrrolidone.

6. The mosquito repellent containing grapefruit ketone according to claim 2, characterized in that: The moisturizing agent is one or any combination of glycerin, propylene glycol, sodium hyaluronate, oat protein, glycine, serine, and alanine; Further, the moisturizing agent is at least one of glycerol and propylene glycol; Furthermore, the moisturizing agent is a combination of glycerin and propylene glycol.

7. The mosquito repellent containing grapefruit ketone according to claim 2, characterized in that: The antibacterial agent is one or any combination of phenoxyethanol, sodium benzoate, 2,4-dichlorobenzyl alcohol, o-cymene-5-ol, benzoic acid, dehydroacetic acid and sodium dehydroacetate; Furthermore, the antibacterial agent is at least one of phenoxyethanol, sodium benzoate, 2,4-dichlorobenzyl alcohol and o-cymene-5-ol.

8. The mosquito repellent containing grapefruit ketone according to any one of claims 1 to 7, characterized in that: The mosquito repellent is in the form of a spray or a coating.

9. The method for preparing the mosquito repellent containing grapefruit ketone according to any one of claims 2 to 8, characterized in that: The following steps are involved: The moisturizer and the dispersant are dissolved in water according to the mass percentage; then the solvent, grapefruit ketone, geraniol and the antibacterial agent are added in sequence, stirred evenly, and filtered to obtain the mosquito repellent.

10. The use of the mosquito repellent containing grapefruit ketone according to any one of claims 1 to 8, characterized in that: Application of the mosquito repellent containing oleocanthal in repelling mosquitoes; Furthermore, the use of the mosquito repellent containing oleocanthal in repelling Aedes mosquitoes; Furthermore, the Aedes mosquito includes at least one of Aedes albopictus and Aedes aegypti.

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