Sodium-potassium-magnesium balanced salt and preparation method thereof

Abstract

The invention provides a sodium-potassium-magnesium balanced salt and a preparation method thereof, and is characterized in that the formula of the sodium-potassium-magnesium balanced salt comprises the following raw materials in parts by weight: 10 parts of magnesium chloride hexahydrate, 10-30 parts of potassium chloride, 1 part of an anti-caking agent and the balance of table salt, totaling 100 parts. According to the product disclosed by the invention, not only are the sensory quality, healthy intake requirements and effects of the product considered through reasonable and scientific design of the formula, but also the prepared sodium-potassium-magnesium balanced salt does not absorb moisture to cake and does not have a layering phenomenon through process innovation; the proportion of sodium, potassium and magnesium of each spoon of potassium-magnesium balanced salt taken by a consumer is ensured to be the same and is also consistent with the design proportion of the formula, so that the product value of the sodium-potassium-magnesium balanced salt is really embodied and exerted.

Description

Technical Field

[0001] The invention belongs to the technical field of food processing, and in particular relates to a sodium-potassium-magnesium balanced salt and a preparation method thereof. Background Art

[0002] The "Report on the Nutrition and Chronic Disease Status of Chinese Residents (2020)" shows that the prevalence of hypertension among residents aged 18 and above in my country is 27.5%, among which the prevalence of hypertension among residents aged 18 to 44, 45 to 59 and 60 and above is 13.3%, 37.8% and 59.2% respectively. The prevalence of hypertension among Chinese residents has generally shown an upward trend, gradually increasing from 5.1% in 1958. At present, the number of adults with hypertension is estimated to be 245 million. High salt intake has always been one of the important causes of high blood pressure and hypertension. Many of the risk factors for hypertension are related to eating habits, including high sodium, low potassium diet, and excessive drinking. Dietary intervention is an important measure for the prevention and treatment of hypertension recognized at home and abroad, and is extremely important for improving blood pressure. As people become more aware of the harm caused by a high-salt diet, they pay more and more attention to healthy eating and advocate salt reduction and low salt.

[0003] The mineral elements sodium, potassium, calcium and magnesium play a central role in the normal regulation of blood pressure. Evidence suggests that current levels of mineral element intake are not optimal for maintaining normal blood pressure, but rather predispose to the development of arterial hypertension. The results of Heikki Karppanen's study show that sodium restriction, potassium supplementation and magnesium supplementation in hypertensive patients can improve the therapeutic effect and reduce the adverse effects of prescribed antihypertensive drugs. Therefore, reducing sodium intake and increasing potassium and magnesium intake can help prevent and treat arterial hypertension.

[0004] Anna-Kaisa Pere et al. studied the protective effects of magnesium and potassium on cyclosporine A-induced cardiac and renal damage in spontaneously hypertensive rats under a high sodium diet. The results showed that both potassium and magnesium supplementation had a protective effect on cyclosporine A-induced hypertension and renal toxicity, but the protective effect of magnesium was more significant. Combined supplementation of potassium and magnesium may be an effective strategy for the prevention and treatment of cyclosporine A-induced hypertension and renal toxicity. Therefore, dietary magnesium, especially in combination with potassium, has a protective effect on cyclosporine A-induced cardiac and renal damage.

[0005] Salt is an indispensable seasoning in people's daily diet. Therefore, adding elemental magnesium and elemental potassium to salt to adjust the balance of sodium, potassium and magnesium intake and thus prevent or assist in the treatment of hypertension is a relatively ideal method. However, in specific applications, there are two technical difficulties: First, in order to achieve better prevention or auxiliary treatment effects on hypertension, it is usually necessary to determine the appropriate sodium, potassium and magnesium ratio in salt. However, the addition of elemental magnesium and elemental potassium may affect the salt's own salt salt, as well as bring in metallic or bitter tastes that are not conducive to the sensory quality of salt. Therefore, how to balance the ratio of sodium, potassium and magnesium to achieve its effect of preventing or treating hypertension without affecting its sensory flavor is the first technical problem that needs to be solved. Secondly, when adding elemental magnesium and elemental potassium to table salt, although there are fewer types of raw materials involved, table salt itself is easy to absorb moisture and agglomerate, and magnesium salt is even more hygroscopic. At the same time, there are differences in the physical properties of table salt mainly composed of sodium chloride, magnesium salt and potassium salt. Therefore, when the designed ratio of sodium, potassium and magnesium is determined, the final product is usually difficult to mix evenly and in a balanced state. As a result, the ratio of sodium, potassium and magnesium may be different each time the product is taken, and may also be different from the designed formula ratio. Summary of the invention

[0006] In view of the above problems, the present invention provides a sodium-potassium-magnesium balanced salt and a preparation method thereof. The product of the present invention not only takes into account the sensory quality, healthy intake requirements and efficacy of the product through the reasonable and scientific design of the formula, but also ensures that the prepared sodium-potassium-magnesium balanced salt will not absorb moisture and agglomerate, and will not have stratification through process innovation, thereby ensuring that the ratio of sodium, potassium and magnesium in each spoonful of potassium-magnesium balanced salt taken by consumers is the same and consistent with the designed ratio of the formula, thereby truly embodying and exerting the product value of the sodium-potassium-magnesium balanced salt.

[0007] The present invention is achieved through the following technical solutions.

[0008] On the one hand, the present invention provides a sodium-potassium-magnesium balanced salt, characterized in that the formula raw materials are calculated by weight as follows: 10 parts of magnesium chloride hexahydrate, 10-30 parts of potassium chloride, 1 part of anti-caking agent, and salt is supplemented to 100 parts.

[0009] Preferably, the formula raw materials of the sodium-potassium-magnesium balanced salt of the present invention are calculated by weight: 10 parts of magnesium chloride hexahydrate, 25 parts of potassium chloride, 1 part of anticaking agent, and 64 parts of salt.

[0010] Preferably, the content of sodium chloride in the table salt is greater than 99.6%.

[0011] On the other hand, the present invention provides a method for preparing a sodium-potassium-magnesium balanced salt, characterized in that it comprises the following steps:

[0012] S1. According to the product formula, weigh and prepare magnesium chloride hexahydrate, potassium chloride and anti-caking agent, and calculate and determine the corresponding required salt mass a;

[0013] S2, adding the magnesium chloride hexahydrate in step S1 into water, stirring and dissolving to obtain a magnesium chloride solution as a wall material, using the potassium chloride particles in step S1 as a core material, and coating the core material using a bottom spray fluidized bed process to obtain an intermediate product 1;

[0014] S3, add salt with a mass of b into water, stir and dissolve to obtain a salt solution as a wall material, use the intermediate product 1 as the core material, and use the bottom spray fluidized bed process to coat the intermediate product 2; wherein b is 0.15-0.2 times of a;

[0015] S4, measuring the particle size range of the intermediate product 2;

[0016] S4, taking salt with a particle size range within the particle size range of the intermediate product 2 and a mass of ab, adding it together with the intermediate product 2 obtained in step S3 and the anti-caking agent in step S1 into a three-dimensional mixer for mixing, to obtain a finished sodium-potassium-magnesium balanced salt.

[0017] Preferably, in step S1, the particle size of potassium chloride is 0.30 mm to 0.85 mm.

[0018] Preferably, in step S2, the weight ratio of magnesium chloride hexahydrate to water is 1:0.5-1; in step S3, the weight ratio of salt to water is 1:2.5-3.5.

[0019] Preferably, in steps S2 and S3, the parameters of the bottom spray fluidized bed process are as follows: the air inlet temperature is 85-105° C., the initial speed of the infusion pump is set to 2-4 rpm, after the coating starts, the speed is increased by 1 rpm every 10 minutes until it increases to 6-8 rpm and remains constant, and drying is continued for 15-30 minutes after the magnesium chloride solution is sprayed.

[0020] Preferably, in steps S2 and S3, the parameters of the bottom spray fluidized bed process are as follows: a fan frequency of 40 Hz, an air inlet temperature of 90° C., an infusion pump speed of 3 rpm, and after the start of coating, the speed is increased by 1 rpm every 10 min until it increases to 6 rpm and remains constant. After the magnesium chloride solution is sprayed, drying is continued for 20 min.

[0021] Preferably, in step S4, the mixing time is 20 to 35 minutes.

[0022] Compared with the prior art, the beneficial effects of the present invention include: the innovative ideas of the sodium-potassium-magnesium balanced salt of the present invention mainly include two aspects, one is the balance of product formula design, that is, the present invention selects suitable raw materials as the source of sodium, potassium and magnesium elements, and optimizes the ratio of each raw material, which can not only ensure the sensory quality of the product so that it is acceptable to consumers, but also the product meets the recommended appropriate intake requirements of potassium, sodium and magnesium elements, thereby matching consumers' pursuit of a healthy diet. In addition, the product of the present invention also has a certain effect of preventing or assisting in the treatment of hypertension, achieving a balance between the sensory quality of the final product, the healthy intake requirements and the efficacy. Second, process improvement ensures the balance of the product when it is taken. Specifically, the formula raw materials of the sodium-potassium-magnesium balanced salt of the present invention only include hexahydrate magnesium chloride, potassium chloride, an anti-caking agent and salt. Therefore, the prior art usually thinks of mixing the above raw materials directly. However, the applicant found that food-grade magnesium chloride hexahydrate is flaky crystals, which cannot be directly mixed with sodium chloride and potassium chloride particles. Therefore, the present invention first adopts a first coating, and the magnesium chloride is dissolved in water and then coated on the surface of potassium chloride particles by a bottom spray fluidized bed coating method, thereby preparing an intermediate product 1. In addition, since magnesium chloride is very easy to absorb moisture, the present invention innovatively performs a second coating on the basis of the first coating, that is, adopts a secondary coating process, and the salt is dissolved in water and then evenly coated on the surface of the intermediate product 1, thereby preparing an intermediate product 2, thereby avoiding exposure of magnesium chloride to the air, so as to prevent the product from absorbing moisture and agglomerating and affecting the product after mixing and when it is taken. Uniformity; At the same time, the applicant found in the exploration that due to the large proportion of salt in the sodium potassium magnesium balanced salt formula, if the second coating dissolves all the salt in the formula as the wall material, although the subsequent production process can be simplified, the particle size of the intermediate product 2 made by the second coating will be too large, and the coating time will also be too long, which will increase the production cost; Therefore, the present invention innovatively uses part of the salt in the formula as the wall material for the second coating, and then mixes the remaining salt with the prepared intermediate product 2, thereby better solving the above problems; Further, before mixing, the present invention also innovatively detects the particle size range of the intermediate product 2 first, and then selects the salt with a particle size within the particle size range of the intermediate product 2 for the final mixing, which can maximize the uniformity of the product after mixing, so that the product can be packaged, transported and stored in turn to enter the consumption link, and the product will not be stratified due to uneven particle size. Therefore, when consumers use the product of the present invention, the sodium potassium magnesium ratio of each spoonful of sodium potassium magnesium balanced salt they take is the same, and it will also be consistent with the design ratio of the formula. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 This is a scanning electron microscope image at 200 times magnification of the intermediate product 1 prepared in Example 2;

[0024] Figure 2This is a scanning electron microscope image at 50 times magnification of the intermediate product 1 prepared in Example 2;

[0025] Figure 3 This is a scanning electron microscope image at 200 times magnification of the intermediate product 2 prepared in Example 2;

[0026] Figure 4 This is a scanning electron microscope image at 50 times magnification of the intermediate product 2 prepared in Example 2;

[0027] Figure 5 Detect radar images for electronic tongue;

[0028] Figure 6 The moisture absorption rate diagram of the sodium potassium magnesium balanced salt prepared in Example 2;

[0029] Figure 7 This is a graph showing the moisture absorption rate of the sodium-potassium-magnesium balanced salt prepared in Comparative Example 1;

[0030] Figure 8 This is the moisture absorption rate diagram of the sodium potassium magnesium balanced salt prepared in Comparative Example 2. DETAILED DESCRIPTION

[0031] The present invention is further described below in the form of specific embodiments in conjunction with the accompanying drawings. It should be pointed out that the following implementation modes are only illustrative descriptions of the present invention in the form of examples, but the protection scope of the present invention is not limited thereto. All equivalent replacements made by technicians in this field to the present invention in the spirit of the present invention shall fall within the protection scope of the present invention.

[0032] Example 1

[0033] The invention relates to the screening of product raw materials and determination of the formula of the sodium potassium magnesium balanced salt.

[0034] 1. Selection of raw materials

[0035] The present invention selects salt that complies with the national standard GB 2712 and has a sodium chloride content greater than 99.6% as the sodium element raw material;

[0036] In food processing, potassium chloride is commonly used as a food-grade compound rich in potassium, so the present invention uses potassium chloride as a raw material for potassium. Food-grade compounds rich in magnesium mainly include magnesium sulfate and magnesium chloride. According to national standards, magnesium sulfate is not allowed to be used in condiments, so the present invention uses food-grade magnesium chloride hexahydrate as a raw material for magnesium.

[0037] 2. Determination of formula

[0038] After checking, the amount of magnesium sulfate heptahydrate added in Finland's "pan salt" is 12% and the amount of magnesium sulfate heptahydrate added in Japan's low sodium salt is 10%, and the former is supported by relevant efficacy tests, so the present invention selects 10% of magnesium chloride hexahydrate, which is basically the same as the amount of magnesium added in the 12% magnesium sulfate heptahydrate formula. Since the addition range of potassium chloride is 10%-35% as stipulated in the national standard GB 2712 for edible salt, the following three groups of formulas are selected for experimentation in this embodiment: in parts by mass, magnesium chloride hexahydrate is fixed to 10 parts, potassium chloride is 10 parts, 20 parts, and 30 parts respectively, and anti-caking agent is 1 part, and salt is supplemented to 100 parts, as shown in Table 1.

[0039] Table 1 Formulation design

[0040]

[0041] 3. Experimental results

[0042] The three groups of formulated products in Table 1 and the common food salt reference sample that meets the national standard GB 2712 were respectively prepared into 0.5% brine. The saltiness, bitterness, and metallic taste of the three groups of samples were evaluated manually compared with the reference sample. The specific results are shown in Tables 2, 3 and 4.

[0043] Table 2 Saltiness of different sodium, potassium and magnesium formulas

[0044]

[0045]

[0046] Note: The salinity of the reference sample is set to 100, and 6 gradients are set: 60, 70, 80, 90, 95, and 100.

[0047] Table 3 Bitterness of different sodium, potassium and magnesium formulas

[0048]

[0049] Note: A. Far lower than the standard sample. B. Lower than the standard sample. C. Same as the standard sample. D. Higher than the standard sample. E. Far higher than the standard sample.

[0050] Table 4 Investigation of metallic taste of different sodium potassium magnesium formulas

[0051]

[0052]

[0053] Note: A. Same as the standard sample. B. Slight metallic taste, acceptable. C. Strong metallic taste, unacceptable.

[0054] As shown in Table 2, when the potassium chloride in the formula is 30 parts, that is, when the potassium chloride addition amount increases to 30%, the saltiness score is only 84.6, which shows that when the potassium chloride addition amount is too large, the saltiness of the product decreases significantly. As shown in Tables 3 and 4, most people think that the bitterness, astringency and metallic taste of the three samples are not much different from the reference sample.

[0055] Studies have shown that when the mass ratio of sodium to potassium is 1:1, the blood pressure reduction effect is the best and most beneficial to health. Considering that the greater the amount of potassium chloride added, the closer the mass ratio of sodium to potassium is to 1, and the saltiness is significantly reduced when the potassium chloride addition is increased to 30%, by consulting medical information, dietary nutrition guidelines for residents and foreign low-sodium salt formulas, it is finally determined that 25 parts of potassium chloride in the formula of the present invention is more suitable (the amount of potassium chloride added is 25%), that is, the formula raw materials of the sodium-potassium-magnesium balanced salt of the present invention are calculated by weight: 10 parts of magnesium chloride hexahydrate, 25 parts of potassium chloride, 1 part of anti-caking agent, and 64 parts of salt.

[0056] In addition, the appropriate sodium intake in the 2020 version of the "Guidelines for Good Eating for Chinese Residents" is 1.5g / d, that is, the appropriate dietary intake of sodium chloride is 3.8g. The appropriate sodium intake recommended by the World Health Organization is 100mmol / d, that is, the appropriate dietary intake of sodium chloride is 5.8g. In summary, the appropriate dietary intake of sodium chloride should be 3.8g / d to 5.8g / d. The appropriate potassium intake in the 2020 version of the "Guidelines for Good Eating for Chinese Residents" is 2g / d, that is, the appropriate dietary intake of potassium chloride is 3.82g / d. The most suitable potassium intake for adults in the "Guidelines for Potassium Intake for Adults and Children" formulated by the World Health Organization is 90mmol, that is, the appropriate dietary intake of potassium chloride is 6.71g / d. If potassium is supplemented through salt at 30% of the dietary intake, the appropriate intake of potassium chloride in the sodium-potassium-magnesium balanced salt formula is 1.15g / d to 2g / d. According to the daily intake of 5g sodium-potassium-magnesium balanced salt of the present invention, when the addition of potassium chloride is 25%, the actual intake of potassium chloride is 1.25g, which meets the requirement that the intake of potassium chloride is 1.15g / d~2g / d, and the addition of sodium chloride is 64% at this time, and the actual intake of sodium chloride is 3.25g, which is slightly lower than the requirement that the dietary intake should be 3.8g / d~5.8g / d. But considering other intakes except diet, the intake of sodium chloride is also suitable. In summary, the formula of sodium-potassium-magnesium balanced salt of the present invention, i.e., 10 parts of magnesium chloride hexahydrate, 25 parts of potassium chloride, 1 part of anticaking agent, and 64 parts of salt, meets the recommended intake requirements of the dietary nutrition guide for residents about sodium chloride and green potassium, and also meets the addition requirements of magnesium chloride, and the organoleptic quality is not much different from ordinary salt, and it is also proved by animal experiments that it has certain hypertension prevention or auxiliary treatment effects.

[0057] Example 2

[0058] This embodiment provides a sodium-potassium-magnesium balanced salt, and the preparation method thereof is as follows:

[0059] S1. According to the product formula, weigh and prepare 10kg of magnesium chloride hexahydrate, 25kg of potassium chloride and 1kg of silicon dioxide, and calculate and determine that the corresponding required salt mass a is 64kg;

[0060] S2, adding 10kg of magnesium chloride hexahydrate in step S1 to 6.5kg of water, stirring and dissolving, to obtain a magnesium chloride solution as a wall material for standby use; using 25kg of potassium chloride particles in step S1 as core material, adopting a bottom spray fluidized bed coating process, setting the fan frequency to 40Hz, the air inlet temperature to 90°C, and the infusion pump speed to 3rpm, after starting the coating, increase 1rpm every 10min until it remains constant at 6rpm, and continue drying for 20min after the magnesium chloride solution is sprayed, so that the magnesium chloride is evenly coated on the surface of the potassium chloride particles to obtain an intermediate product 1, which is standby use; the scanning electron microscope 200x and 50x images of the intermediate product 1 are shown in Figure 1 , Figure 2 ; From the scanning electron microscope image, it can be seen that the surface of the intermediate product 1 obtained by the first coating is columnar crystal particles, and the magnesium chloride is evenly coated on the surface of the potassium chloride particles;

[0061] S3. Take 10 kg of salt with a mass b and add it to 30 kg of water, stir and dissolve it thoroughly to obtain a salt solution as a wall material for standby use. Use the intermediate product 1 as the core material, adopt a bottom spray fluidized bed process, set the fan frequency to 40 Hz, the air inlet temperature to 90 ° C, and the infusion pump speed to 3 rpm. After the coating starts, increase 1 rpm every 10 minutes until it remains constant at 6 rpm. After the sodium chloride solution is sprayed, continue drying for 20 minutes, so that the sodium chloride is evenly coated on the surface of the intermediate product 1 particles to obtain the intermediate product 2 for standby use; the scanning electron microscope 200 times and 50 times images of the intermediate product 2 are shown in FIG. Figure 3 , Figure 4 ; From the scanning electron microscope image, it can be seen that the surface of the secondary coated intermediate product 2 is cubic crystal particles, and sodium chloride is evenly coated on the surface of the intermediate product 2;

[0062] S4, the particle size range of the intermediate product 2 is measured to be 0.5 mm-1.0 mm;

[0063] S4, select a sieve with a suitable mesh number, sieve to obtain salt with a particle size range of 0.5mm-1.0mm and a mass of ab, i.e., 54kg, and add the salt together with the intermediate product 2 obtained in step S3 and the silicon dioxide in step S1 into a three-dimensional mixer for mixing, to obtain the finished sodium-potassium-magnesium balanced salt of the present invention.

[0064] Comparative Example 1

[0065] This comparative example provides a sodium-potassium-magnesium balanced salt, and the preparation method thereof is as follows: 10 kg of magnesium chloride hexahydrate is crushed and mixed with 64 kg of edible salt, 25 kg of potassium chloride, and 1 kg of silicon dioxide in a three-dimensional mixer for 30 minutes to obtain the product of comparative example 1.

[0066] Comparative Example 2

[0067] This comparative example provides a sodium-potassium-magnesium balanced salt, and the preparation method thereof is as follows: the intermediate product 1 prepared in Example 2 is mixed with 64 kg of edible salt and 1 kg of silicon dioxide in a three-dimensional mixer for 30 minutes to obtain the product of comparative example 2.

[0068] Example 3

[0069] 1. Sensory evaluation: The finished sodium-potassium-magnesium balanced salts of Example 2, Comparative Examples 1 and 2, as well as edible salt and low sodium salt (25% KCl) were used as experimental objects. The SA402B electronic tongue (Insent, Japan) was used for detection. The artificial lipid membrane sensing technology similar to the working principle of taste bud cells was used to recognize and characterize the taste intensity and taste characteristics. The detection method is as follows: Accurately weigh 0.4g (±0.0003g) of the sample, completely dissolve it in 100mL of the reference solution, take 35mL of the sample for testing on the machine, and repeat the measurement 4 times. The Taste Analysis System Application software provided by the electronic tongue was used to collect and analyze the data. The test results are shown in Tables 5 and Figure 5 .

[0070] Table 5 Electronic tongue detection results

[0071] sample sour bitterness Astringency Bitter aftertaste Astringent aftertaste Umami Richness Salty Salt -0.97 1.03 0.46 0.16 0.02 0.11 0.84 5.82 Low sodium salt -1 0.99 0.45 0.16 0.02 0.11 0.75 5.73 Comparative Example 1 -1 0.98 0.44 0.16 0.02 0.15 0.85 5.53 Comparative Example 2 -1 0.98 0.44 0.17 0.02 0.12 0.76 5.59 Example 2 -0.96 0.95 0.43 0.17 0.03 0.12 0.73 5.54

[0072] From Table 5 and Figure 1 The data show that the saltiness and bitterness values ​​of Example 2, Comparative Example 1 and Comparative Example 2 are consistent, because the raw material ratios of the sodium potassium magnesium balanced salt prepared in Comparative Example 1, Comparative Example 2 and Example 2 are consistent, but the processes are different. The saltiness value of the sodium potassium magnesium balanced salt is slightly lower than that of edible salt and low sodium salt, and the bitterness value is consistent. Therefore, while reducing sodium by 35%, the saltiness value of the sodium potassium magnesium balanced salt only decreases slightly, and the bitterness will not increase due to the addition of potassium chloride and magnesium chloride, and the effect of reducing sodium without reducing saltiness can be basically achieved.

[0073] 2. Mixing uniformity test: The sodium potassium magnesium balanced salts prepared in Example 2, Comparative Example 1 and Comparative Example 2 were tested for mixing uniformity. Samples were taken at the front, back, left and middle positions of the three-dimensional mixer to test the magnesium content. The results are shown in Table 6.

[0074] Table 6 Mixing uniformity test results

[0075]

[0076]

[0077] As shown in the above table, comparative example 1 is to directly mix several materials, and the RSD value is relatively high, and the uniformity is general. Comparative example 2 is to wrap magnesium chloride on the surface of potassium chloride particles, and then mix with the remaining raw materials, and the RSD value is relatively low, and the uniformity is good. And the inventive method, i.e., the sodium potassium magnesium balanced salt RSD prepared by embodiment 2 is the lowest, and it is used by reasonably distributing the edible salt dosage in the formula to twice coating, and by measuring the particle size range of intermediate product 2 at the same time, and selecting the edible salt of suitable particle size range to be finally mixed with intermediate product 2, the uniformity of product mixing can be guaranteed to the greatest extent.

[0078] 3. Hygroscopicity investigation

[0079] Prepare the following saturated solutions with different humidity levels and add them to the bottom of the desiccator.

[0080] Table 7 Saturated solution configuration table at different humidity

[0081] Saturated solution name humidity(%) Potassium acetate 22.5 Magnesium chloride 32.8 Potassium carbonate 43.2 Magnesium Nitrate 54.4 Sodium chloride 75.3 Potassium chloride 84.3 Potassium Nitrate 93.5

[0082] Take a dry stoppered glass weighing bottle (outer diameter 50 mm, height 15 mm), place it in a suitable desiccator (with saturated solution at the bottom) one day before the test, and accurately weigh the weight (m1).

[0083] Take an appropriate amount of the test sample and spread it evenly in the above-mentioned weighing bottle. The thickness of the test sample is generally about 5-10mm. Accurately weigh the weight (m2).

[0084] Open the weighing bottle and place it with the bottle cap under the above-mentioned constant temperature and humidity conditions.

[0085] On the 1st, 3rd, 7th and 15th day respectively, take out the weighing bottle, cover the weighing bottle lid, and accurately weigh the weight (m3); wherein, moisture absorption rate = (m3-m2) / (m2-m1)×100%.

[0086] The test results of product hygroscopicity are shown in Tables 8-10, and Figure 6-Figure 8 .

[0087] Table 8 Example 2 Preparation of Sodium Potassium Magnesium Balance Salt Hygroscopic Test Data Table

[0088]

[0089]

[0090] Table 9 Hygroscopic test data of sodium potassium magnesium balanced salt prepared in comparative example 1

[0091] Saturated salt humidity / % 1d moisture absorption rate / % 3d moisture absorption rate / % 7d moisture absorption rate / % 15d moisture absorption rate / % Potassium acetate 22.5 0.53 0.66 0.75 0.60 Magnesium chloride 32.8 0.85 0.97 1.02 1.08 Potassium carbonate 43.2 1.85 1.68 1.57 1.96 Magnesium Nitrate 54.4 3.77 4.67 5.91 5.81 Sodium chloride 75.3 4.91 7.98 12.28 24.57 Potassium chloride 84.3 8.07 14.67 26.87 50.68 Potassium Nitrate 93.5 13.54 28.42 56.27 87.25

[0092] Table 10 Hygroscopic test data of sodium potassium magnesium balanced salt prepared in comparative example 2

[0093] Saturated salt humidity / % 1d moisture absorption rate / % 3d moisture absorption rate / % 7d moisture absorption rate / % 15d moisture absorption rate / % Potassium acetate 22.5 0.58 0.62 0.77 0.82 Magnesium chloride 32.8 0.88 0.94 1.17 1.01 Potassium carbonate 43.2 1.58 1.78 1.62 1.70 Magnesium Nitrate 54.4 4.08 4.92 5.88 5.57 Sodium chloride 75.3 4.07 6.44 11.01 15.57 Potassium chloride 84.3 7.85 14.27 24.56 45.68 Potassium Nitrate 93.5 12.22 25.95 55.17 83.27

[0094] As can be seen from the above data, when the humidity is 54.4% or less, the sodium potassium magnesium balanced salt prepared in Example 2 and Comparative Example 1 and Comparative Example 2 is substantially non-hygroscopic. When the humidity is above 75.3%, the sodium potassium magnesium balanced salt prepared in Example 2 and Comparative Example 1 and Comparative Example 2 increases rapidly with the increase of the moisture absorption time. When the humidity is 84.3% and 93.5%, the moisture absorption rates of Comparative Example 1 and Comparative Example 2 are substantially the same, while the moisture absorption rate of Example 2 is significantly lower than that of Comparative Example 1 and Comparative Example 2. Because magnesium chloride is exposed to the outside in Comparative Example 1 and Comparative Example 2, and magnesium chloride has strong hygroscopicity, the sodium potassium magnesium balanced salt of the present invention wraps magnesium chloride in the middle of the particles, so under higher humidity conditions, the sodium potassium magnesium balanced salt has a stronger anti-hygroscopicity.

[0095] Example 4

[0096] Animal experiment on the effect of sodium-potassium-magnesium balanced salt on maintaining healthy blood pressure level

[0097] 1. Test sample

[0098] Edible salt, specification: 300g / bag, batch number: 20231229, manufacturer: Xuetian Salt Group Co., Ltd., valid until: 2026.12.28, storage conditions: room temperature.

[0099] Low sodium salt (KCl 15%), batch number: 20231229, specification: 300g / bag, manufacturer: Xuetian Salt Group Co., Ltd., valid until: 2026.12.28, storage conditions: room temperature.

[0100] Low sodium salt (KCl 25%), batch number: 20231229, specification: 300g / bag, manufacturer: Xuetian Salt Group Co., Ltd.; valid until: 2026.12.28, storage conditions: room temperature.

[0101] Low sodium salt (KCl 35%), batch number: 20240129, specification: 300g / bag, manufacturer: Xuetian Salt Group Co., Ltd., valid until: 2027.01.27, storage conditions: room temperature.

[0102] The sodium-potassium-magnesium balanced salt prepared in Example 2, batch number: 20240129, specification: 300 g / bag, manufacturer: Xuetian Salt Group Co., Ltd., valid until: 2027.01.27, storage conditions: room temperature.

[0103] 2. Positive control

[0104] Irbesartan tablets, batch number: 4230801056, specification: 0.15g*7 tablets / box, manufacturer: Shenzhen Haibin Pharmaceutical Co., Ltd.

[0105] 3. Experimental animals

[0106] 125 SPF male SHR rats and 8 WKY rats, weighing 180.0-211.1 g, were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., with the experimental animal use license number: SYXK (Xiang) 2020-0015, the experimental animal production license number: SCXK (Beijing) 2021-0006, and the animal quality certificate numbers are: 11011241105526281 and 110011241105526364. The animals were kept in the D area of ​​the barrier environment animal laboratory of our company, with a light intensity of 12h / 12h alternating light and dark, a laboratory temperature range of 20.0-26.0℃, and a relative humidity range of 40%-70%. The animals were routinely raised and fed and watered freely, and all animals were fed adaptively before the experiment began.

[0107] 4. Main instruments

[0108] ME2002E / 02 electronic balance (Center No.: 779, Mettler); non-invasive blood pressure measuring instrument (Center No.: 806 / 807, Shanghai Xinruan Information Technology Co., Ltd.).

[0109] 5. Experimental methods

[0110] 125 SPF male SHR rats and 8 WKY rats that passed the quarantine were selected, with a body weight of 180.0-211.1 g. After 5 days of adaptive feeding, the SHR rats were randomly divided into 12 groups according to their body weight, including model control group, irbesartan tablet group, low-dose edible salt group, high-dose edible salt group, low-sodium salt (KCl 15%) low-dose group, low-sodium salt (KCl 15%) high-dose group, low-sodium salt (KCl 25%) low-dose group, low-sodium salt (KCl 25%) high-dose group, low-sodium salt (KCl 35%) low-dose group, low-sodium salt (KCl 35%) high-dose group, sodium-potassium-magnesium balanced salt low-dose group, and sodium-potassium-magnesium balanced salt high-dose group, with 8 rats in each group, and 8 male WKY rats were taken as blank control group. Each drug-treated group was given the corresponding sample by gavage at 10 mL / kg, and the blank control group and model control group were given an equal volume of pure water by gavage, once a day, for 4 consecutive weeks. The blood pressure and heart rate of the animals were measured before and on the 7th, 14th, 21st, and 28th days after the sampling.

[0111] 6. Dosage design

[0112] Based on the recommended daily intake of table salt for humans being 5 g / day, calculated according to the average adult body weight of 60 kg, it is 0.083 g / kg. In this experiment, the low and high doses of table salt were respectively 1 and 2 times the equivalent dose for rats converted by the kilogram body weight method, that is, 0.083 and 0.167 g / kg.

[0113] The clinically recommended dosage of irbesartan tablets is 0.15 g / day. The equivalent dose for rats converted by body surface area is 0.15 g / day * 0.018 / 0.2 kg = 0.0135 g / kg. In this experiment, 1 times the equivalent dose for rats converted by body surface area was used as the administration dosage of irbesartan tablets. See Table 11 for details.

[0114] Table 11 Experimental groupings and dose designs

[0115]

[0116] 7. Index detection

[0117] Using a non-invasive blood pressure monitor, the blood pressure of rats was measured indirectly by the tail artery method. The blood pressure and heart rate of the animals were detected on days 0, 7, 14, 21, and 28 before dosing. At each measurement, there was a certain time interval, and the average value was taken from three consecutive readings with a heart rate change ≤ 10 beats / min and a blood pressure change ≤ 6 mmHg.

[0118] 8. Data processing and statistical analysis

[0119] The significant figures of the data in this experiment were rounded according to the rule of rounding up or down, and statistical analysis was carried out in accordance with the provisions of "Statistical Processing of Experimental Data" (SOP-R-d-003). The software used for statistics was SPSS 23.0. Blood pressure measurement was quantitative data, and analysis of variance was used. However, according to the procedure of analysis of variance, a homogeneity of variance test was first carried out. If the variances were homogeneous, the F value was calculated. If the F value < F0.05, the conclusion was that there was no significant difference among the means of each group; if the F value ≥ F0.05 and P ≤ 0.05, pairwise comparison of the means between multiple experimental groups and a control group was used for statistics; for non-normal or heterogeneous variance data, appropriate variable transformation was carried out. After meeting the requirements of normality or homogeneity of variance, the transformed data was used for statistics; if the purpose of normality or homogeneity of variance was still not achieved after variable transformation, the rank sum test was used for statistics.

[0120] 9. Experimental results

[0121] Compared with the blank control group, the systolic blood pressure of rats W1, W2, W3, and W4 in the model control group were significantly increased (P≤0.01). Compared with the model control group, the systolic blood pressure of rats W3 and W4 in the irbesartan tablets group and W3 in the low-dose sodium-potassium-magnesium balanced salt group were significantly decreased (P≤0.05), and there was no statistical difference in the systolic blood pressure of the other groups at each time point (P>0.05). Compared with the low-dose and high-dose edible salt groups, there was no significant difference in the systolic blood pressure of the low-dose and high-dose groups of different gradients of low sodium salt (P>0.05). Compared with the low-dose sodium-potassium-magnesium balanced salt group, the systolic blood pressure of rats W3 in the low-dose edible salt group, the low-dose low sodium salt (KCl 15%) group, and the low-dose low sodium salt (KCl 25%) group was significantly increased (P≤0.05 or P≤0.01).

[0122] Table 12 Effects on systolic blood pressure in rats ( mmHg, n=8)

[0123] Group W1 W2 W3 W4 Blank control group 132.9±13.0 130±9.7 129.1±9.8 134.8±7 Model control group 177.3±26.6** 189.7±16.9** 201.6±12.5** 195.2±18.2** Irbesartan Tablets 169.1±19.7 174±28.6 <![CDATA[181.3±19.6 + ]]> <![CDATA[171.8±23.6 + ]]> Low-dose salt group 174.7±22.4 198.8±15.3 <![CDATA[205.3±21.4 ## ]]> 185.8±13.7 Low sodium salt (KCl 15%) low dose group 188.5±17.1 186.4±20.9 <![CDATA[203.0±14.7 ## ]]> 192.8±24.2 Low sodium salt (KCl 25%) low dose group 169.3±16.1 197.5±10.6 <![CDATA[197.6±9.5 ## ]]> 181.5±14.3 Low sodium salt (KCl 35%) low dose group 182.9±25.6 203.8±32.0 192.6±20.1 194.7±31.0 Low-dose sodium-potassium-magnesium balanced salt group 188.5±23.2 184.9±22.3 <![CDATA[180.0±21.1 ++ ]]> 184.7±19.1 High-dose salt group 179.9±21.9 192.5±26.9 191.2±16.7 188.0±27.4 Low sodium salt (KCl 15%) high dose group 189.8±23.3 175.3±28.5 205.2±15.2 197.8±27.2 Low sodium salt (KCl 25%) high dose group 183.5±18.1 193.5±18.6 189.9±16.4 174.1±23.0 Low sodium salt (KCl 35%) high dose group 188.0±15.8 193.9±33.4 195.4±20.5 191.1±10.9 High-dose sodium-potassium-magnesium balanced salt group 185.6±13.6 191.8±9.8 189.8±9.5 181.9±11.8

[0124] Note: Compared with the blank control group, ** P<0.01; compared with the model control group, + P<0.05; compared with sodium, potassium and magnesium balanced salt, # P<0.05 or ## P<0.01.

[0125] 10 Experimental Results

[0126] Salt sensitive hypertension (SSH) is a special type of hypertension. Studies have found that compared with essential hypertension (EH), SSH patients have more severe kidney damage. The reason is that high salt intake causes increased blood pressure and high salt itself can cause kidney damage. Many reports have pointed out that regulating the intake of sodium, potassium and magnesium is beneficial to the prevention and control of hypertension. Wang Youliang et al. showed that the sodium-potassium ratio intervention method can effectively reduce the systolic, diastolic and mean blood pressure of hypertensive patients. In this project, the test sample was given to SHR rats by oral gavage for 28 days. The results showed that compared with the blank control group, the systolic, diastolic, mean blood pressure and heart rate of rats W1, W2, W3 and W4 in the model control group were significantly increased, indicating that the model was successful. The experimental results showed that compared with the low-dose group of sodium-potassium-magnesium balanced salt, the systolic blood pressure of W3 in the low-dose group of edible salt, the low-dose group of low sodium salt (KCl 15%) and the low-dose group of low sodium salt (KCl 25%) was significantly increased. This suggests that sodium-potassium-magnesium balanced salt is superior to low-dose low-sodium salt groups at different concentration gradients in reducing systolic blood pressure in hypertensive rats.

[0127] In summary, oral administration of different doses of edible salt and low sodium salt for 28 consecutive days had no significant effect on the blood pressure of SHR rats. However, the low-dose group of sodium-potassium-magnesium balanced salt can significantly reduce the W3 systolic blood pressure of SHR rats, which has a certain effect on the prevention or auxiliary treatment of hypertension.

Claims

1. A sodium-potassium-magnesium balanced salt, characterized in that The raw materials of the formula are calculated by weight as follows: 10 parts of magnesium chloride hexahydrate, 10-30 parts of potassium chloride, 1 part of anti-caking agent, and salt is supplemented to 100 parts.

2. A sodium-potassium-magnesium balanced salt as claimed in claim 1, characterized in that The raw materials of the formula are calculated by weight: 10 parts of magnesium chloride hexahydrate, 25 parts of potassium chloride, 1 part of anti-caking agent and 64 parts of salt.

3. A sodium-potassium-magnesium balanced salt as claimed in claim 2, characterized in that The table salt meets the requirements of national standard GB2712.

4. A method for preparing a sodium-potassium-magnesium balanced salt, characterized in that: The steps include: S1. According to the product formula, weigh and prepare magnesium chloride hexahydrate, potassium chloride and anti-caking agent, and calculate and determine the corresponding required salt mass a; S2, adding the magnesium chloride hexahydrate in step S1 into water, stirring and dissolving to obtain a magnesium chloride solution as a wall material, using the potassium chloride in step S1 as a core material, and coating the solution using a bottom spray fluidized bed process to obtain an intermediate product 1; S3, adding salt with a mass of b into water, stirring and dissolving to obtain a salt solution as a wall material, using the intermediate product 1 obtained in step S2 as a core material, and coating the intermediate product 2 using a bottom spray fluidized bed process; wherein b is 0.15-0.2 times of a; S4, measuring the particle size range of the intermediate product 2; S4, taking salt with a particle size range within the particle size range of the intermediate product 2 and a mass of ab, adding it together with the intermediate product 2 obtained in step S3 and the anti-caking agent in step S1 into a three-dimensional mixer for mixing, to obtain a finished sodium-potassium-magnesium balanced salt.

5. The method for preparing a sodium-potassium-magnesium balanced salt according to claim 4, characterized in that: In the step S1, the particle size of potassium chloride is 0.30 mm to 0.85 mm.

6. The method for preparing a sodium-potassium-magnesium balanced salt according to claim 4, characterized in that: In the step S2, the weight ratio of magnesium chloride hexahydrate to water is 1:0.5-1; in the step S3, the weight ratio of salt to water is 1:2.5-3.

5.

7. The method for preparing a sodium-potassium-magnesium balanced salt according to claim 4, characterized in that: In the steps S2 and S3, the parameters of the bottom spray fluidized bed process are as follows: the air inlet temperature is 85-105° C., the initial speed of the infusion pump is set to 2-4 rpm, after the coating starts, the speed is increased by 1 rpm every 10 minutes until it increases to 6-8 rpm and remains constant, and after the magnesium chloride solution is sprayed, drying is continued for 15-30 minutes.

8. The method for preparing a sodium-potassium-magnesium balanced salt according to claim 7, characterized in that: In the steps S2 and S3, the parameters of the bottom spray fluidized bed process are as follows: the fan frequency is 40 Hz, the air inlet temperature is 90° C., the infusion pump speed is set to 3 rpm, and after the coating starts, the speed is increased by 1 rpm every 10 minutes until it increases to 6 rpm and remains constant. After the magnesium chloride solution is sprayed, drying is continued for 20 minutes.

9. The method for preparing a sodium-potassium-magnesium balanced salt according to claim 7, characterized in that: In step S4, the mixing time is 20 to 35 minutes.

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