Composition with scalp care effect as well as preparation method and application thereof

Abstract

The invention belongs to the field of cosmetics, and discloses a composition with a scalp care effect and a preparation method and application thereof. The composition is prepared from the following raw materials in parts by weight: 0.01 to 1 part of piroctone olamine salt, 0.0001 to 3 parts of citric acid and 0.0001 to 1 part of sarcosine. The composition disclosed by the invention has the effects of improving the phenomenon of scalp allergy, controlling oil for a long time, and improving the problems of greasy and non-refreshing hair, itching and desquamation, inflammatory lumps, appearance collapse and lack of fluffy feeling and the like.

Description

Technical Field

[0001] The invention belongs to the field of cosmetics, and in particular relates to a composition with scalp care efficacy and a preparation method and use thereof. Background Art

[0002] It is generally believed that the colonization of Malassezia yeast and the secretion of oil on the scalp are the main causes of dandruff. Since Malassezia cannot synthesize fatty acids, it tends to inhabit the parts of the human body and warm-blooded animals that secrete lipids, such as the scalp, face, back and chest. Malassezia fungi and Propionibacterium bacteria can convert lipids secreted by hair follicle glands into free fatty acids. The sebum secreted by the hair follicle sebaceous glands and sweat glands of the human body includes triglycerides, squalene, cholesterol esters, waxes and cholesterol.

[0003] Antidandruff agents are mainly divided into the following three types according to their different mechanisms of action: keratin exfoliants, cell growth inhibitors and antimicrobial agents; earlier antidandruff agents include sulfur, salicylic acid, selenium disulfide, etc. Salicylic acid and tar are not designed for antifungal effects, so they do not have obvious antifungal effects, have poor antidandruff effects, are highly irritating, and can easily damage the skin; antidandruff cosmetics with selenium disulfide as the main active ingredient are also highly irritating, and the hair feels rough after use. If not rinsed thoroughly, the hair may lose color. A small number of users will experience accelerated hair loss, and there is an odor. Later, zinc pyrithione (ZPT, 1-hydroxypyridine-2-sulfur copper zinc, also known as pyrithione zinc), climbazole (trade name climbazole, CLM) and piroctone olamine salt (OCT, 1-hydroxy-4-methyl-6-(2,4,4-trimethylphenyl) pyridone olamine complex salt) appeared one after another. Due to their good safety and anti-dandruff effects, they are widely used in current anti-dandruff products. In addition, promoting the proliferation of keratinocytes and the synthesis of sebum on the head will more directly restore and improve the barrier function of the scalp stratum corneum. Therefore, the use of surfactants, scalp stratum corneum lipid compensatory substances and antibacterial active substances will be more conducive to improving the scalp health of patients with dandruff.

[0004] Sulfate surfactants are a common type of surfactant that are widely used in shampoos and cleaning products because of their good cleaning ability and foaming properties. However, it may also cause redness and allergic reactions on the scalp, and may even cause frizzy and split hair; in addition, it may also damage the skin barrier, leading to dry skin and increased likelihood of skin irritation. Studies have shown that surfactants such as sodium lauryl sulfate (SLS), sodium allyl sulfonate (ALS), sodium lauryl sulfate (SLES), and sodium lauryl ether sulfate can inhibit enzymes that control desquamation, leading to dry skin and impaired barrier function. Summary of the invention

[0005] In view of the above-mentioned shortcomings of the prior art, the object of the present invention is to provide a composition with scalp care effect and a preparation method and use thereof, so as to solve the problems in the prior art.

[0006] To achieve the above objectives and other related objectives, the present invention is achieved through the following technical solutions.

[0007] The first aspect of the present invention provides a composition having scalp care efficacy, the composition comprising the following raw materials in parts by weight:

[0008] Piroctone ethanolamine salt 0.01~1 part

[0009] Citric acid 0.0001~3 parts

[0010] Sarcosine 0.0001 to 1 part.

[0011] In some embodiments, the weight portion of the piroctone olamine salt can be 0.01 to 0.2 parts, 0.1 to 0.5 parts, or 0.4 to 1 parts. In some preferred embodiments, it is 0.01 parts, 0.1 parts, 0.2 parts, or 0.3 parts.

[0012] In some embodiments, the weight portion of citric acid can be 0.01 to 0.3 parts, 0.2 to 1.6 parts, or 1 to 3 parts. In some preferred embodiments, it is 0.1 parts, 0.005 parts, or 0.05 parts.

[0013] In some embodiments, the weight portion of sarcosine can be 0.003 to 0.2 parts, 0.1 to 0.7 parts, or 0.6 to 1 parts. In some preferred embodiments, it is 0.01 parts, 0.001 parts, 0.15 parts, or 0.1 parts.

[0014] In certain embodiments, the CAS number of sarcosine is 125275-25-10.

[0015] In some specific embodiments, the composition comprises the following raw materials in parts by weight:

[0016] 0.3 parts of piroctone ethanolamine salt

[0017] 0.1 part citric acid

[0018] 0.15 parts of sarcosine.

[0019] Another aspect of the present invention provides a method for preparing the composition as described above, comprising the steps of:

[0020] The raw materials are mixed according to parts by weight to obtain the composition.

[0021] Another aspect of the present invention provides use of the composition as described above as a raw material in the preparation of a cleaning product.

[0022] In some embodiments, the product is selected from at least one of shampoo, hair essence, conditioner, hair spray, and hair mask, but is not limited to shampoo, hair essence, conditioner, hair spray, and hair mask. Any form of hair care products is within the scope of protection of this application.

[0023] Another aspect of the present invention provides a cleaning product, comprising the composition as described above.

[0024] In certain embodiments, the hair care product is shampoo.

[0025] In certain specific embodiments, based on the total mass of the cleaning product, the mass concentration of the composition is 0.0001-5%, or 0.0001-0.1%, or 0.1-1%, or 1-5%, or 0.25%, 0.40%, 0.45%, or 0.55%.

[0026] In certain specific embodiments, the cleaning product further comprises one or more of a non-sulfate surfactant, a chelating agent, a conditioning agent, a preservative and a solvent.

[0027] In certain more specific embodiments, the non-sulfate surfactant is selected from one or both of sodium cocoyl isethionate and cocamidopropyl betaine.

[0028] In some specific embodiments, based on the total weight of the cleaning product, the amount of the non-sulfate surfactant added is 1-60%, preferably 35%.

[0029] In certain more specific embodiments, the chelating agent is selected from disodium ethylenediaminetetraacetate.

[0030] In some specific embodiments, based on the total weight of the cleaning product, the amount of the chelating agent added is 0.01-0.5%, preferably 0.1%.

[0031] In certain more specific embodiments, the conditioning agent is selected from polyquaternium-10 (cationic cellulose).

[0032] In some specific embodiments, based on the total weight of the cleaning product, the amount of the conditioning agent added is 0.01-1%, preferably 0.3%.

[0033] In certain more specific embodiments, the preservative is selected from one or both of sodium benzoate and phenoxyethanol.

[0034] In some specific implementations, based on the total weight of the cleaning product, the amount of the preservative added is 0.01-1.5%, preferably 0.9%.

[0035] In some more specific embodiments, the solvent is selected from water, preferably purified water.

[0036] Preferably, the cleaning product comprises a composition, a non-sulfate surfactant, a chelating agent, a conditioning agent, a preservative and a solvent.

[0037] In certain embodiments, the hair care product is a hair care serum.

[0038] In certain specific embodiments, based on the total mass of the cleaning product, the mass concentration of the composition is 0.0001-5%, or 0.0001-0.1%, or 0.1-1%, or 1-5%, or 0.25%, 0.40%, 0.45%, or 0.55%.

[0039] In certain specific embodiments, the cleaning product further comprises one or more of a thickener, a moisturizer, a cooling agent, an antioxidant and a solvent.

[0040] In certain more specific embodiments, the thickening agent is selected from hydroxyethyl cellulose.

[0041] In some specific implementations, based on the total weight of the cleaning product, the amount of the thickener added is 0.01-1%, preferably 0.2%.

[0042] In certain more specific embodiments, the humectant is selected from one or more of glycerin, panthenol, pentylene glycol and 1,2-hexanediol.

[0043] In some specific implementations, based on the total weight of the cleaning product, the amount of the moisturizer added is 0.01-30%, preferably 4.7%.

[0044] In certain more specific embodiments, the cooling agent is selected from menthol lactate.

[0045] In some specific implementations, based on the total weight of the cleaning product, the amount of the cooling agent added is 0.01-4%, preferably 0.1%.

[0046] In certain more specific embodiments, the antioxidant is selected from p-hydroxyacetophenone.

[0047] In some specific implementations, based on the total weight of the cleaning product, the amount of the antioxidant added is 0.01-2%, preferably 0.4%.

[0048] Preferably, the cleaning product comprises a composition, a thickener, a moisturizer, a cooling agent, an antioxidant and a solvent.

[0049] In some more specific embodiments, the solvent is selected from water, preferably purified water.

[0050] Another aspect of the present invention provides use of the composition as described above or the care product as described above in scalp care.

[0051] In certain embodiments, the scalp care refers to alleviating scalp allergies or controlling oiliness.

[0052] In certain specific embodiments, the scalp irritation is caused by sulfate surfactants.

[0053] In certain more specific embodiments, the sulfate surfactant is selected from one or more of sodium dodecyl sulfate, sodium lauryl sulfate, sodium allyl sulfonate, sodium dodecyl sulfate and sodium dodecyl ether sulfate.

[0054] In a specific embodiment, it is sodium lauryl sulfate (SLS).

[0055] The present application uses a patch device to apply sulfate surfactants to the skin surface for 24 hours, and it is found that it will cause skin allergy redness and erythema; after applying the solution of the composition of the present application, it is found that there is no redness, and the erythema caused by sulfate surfactants can also be eliminated. In addition, the composition of the present application and the culture medium are mixed to culture epidermal cells, which can alleviate the decrease in cell activity caused by sulfate surfactants. It is generally stated that the composition of the present application has the effect of relieving scalp allergies.

[0056] In addition, the cleaning product formed by the composition of the present application can effectively control the oil content of the skin and control the ability of sebaceous gland cells to synthesize oil from the source, which shows that the composition of the present application has an oil control effect.

[0057] Compared with the prior art, the present invention has the following beneficial effects:

[0058] The composition with scalp care effect of the present application has significant oil control effect and skin allergy relief effect, has a good feeling of use, and improves the problems of greasy and unclear scalp, itching and desquamation, inflammatory pimples, collapsed appearance and lack of fluffiness. BRIEF DESCRIPTION OF THE DRAWINGS

[0059] Figure 1 Before and after pictures of one of the volunteers.

[0060] Figure 2 is the oil content value of the skin in each test group.

[0061] Figure 3 The graphs were prepared using GraphPad Prism 8.0 according to Table 6. DETAILED DESCRIPTION

[0062] The following is a description of the implementation of the present invention by means of specific embodiments. Those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification.

[0063] Before further describing the specific embodiments of the present invention, it should be understood that the scope of protection of the present invention is not limited to the specific embodiments described below; it should also be understood that the terms used in the examples of the present invention are intended to describe specific embodiments, rather than to limit the scope of protection of the present invention. The test methods in the following examples without specifying specific conditions are generally carried out under conventional conditions or under conditions recommended by the manufacturers.

[0064] When the embodiments give numerical ranges, it should be understood that, unless otherwise specified in the present invention, both endpoints of each numerical range and any numerical value between the two endpoints can be selected. Unless otherwise defined, all technical and scientific terms used in the present invention have the same meaning as those generally understood by those skilled in the art. In addition to the specific methods, equipment, and materials used in the embodiments, according to the grasp of the prior art by those skilled in the art and the record of the present invention, any methods, equipment, and materials of the prior art similar or equivalent to the methods, equipment, and materials described in the embodiments of the present invention can also be used to realize the present invention.

[0065] Piroctone olamine salt (trade name OCT), citric acid and sarcosine were purchased from Nanjing Ruibo Technology Co., Ltd.; sebaceous gland cells (SZ95) were purchased from Qingqi (Shanghai) Biotechnology Development Co., Ltd.; HaCaT cells were purchased from Shanghai Jingkang Bioengineering Co., Ltd.; the spot tester was purchased from Beijing Baiyi Yida Technology Development Co., Ltd.; DMEM culture medium was purchased from Gibco, USA.

[0066] Examples 1-4

[0067] According to the formula in Table 1, piroctone olamine salt, citric acid and sarcosine are mixed to obtain a composition having scalp care efficacy.

[0068] Then, the composition and purified water were mixed at a mass volume ratio of 1 g:99 g to obtain an aqueous solution of the composition.

[0069] There are 8 groups of aqueous solutions of the composition. Among them, Examples 1-4 and Comparative Examples 1-3 have a negative control group. SLS is prepared into a 2wt% SLS aqueous solution with purified water. 0.02mL of 2wt% SLS solution is placed in the center of each patch chamber.

[0070] The effects of the aqueous solutions of the compositions of Examples 1-4 and Comparative Examples 1-3 on relieving skin allergies were investigated, and the specific operations were as follows:

[0071] 1) According to the inclusion and exclusion criteria of the Cosmetic Safety Technical Specifications, 35 eligible subjects were selected and enrolled. They were asked to sit quietly for 30 minutes in a constant temperature and humidity environment (50%±5%, 20℃±2℃).

[0072] 2) Eight areas of 3cm*3cm in size were selected on the inner side of the forearms of both hands of each subject, with a distance of 2cm between each area. A spot tester containing SLS aqueous solution in the center of the chamber was applied to each area for 24 hours, and then the spot tester was removed.

[0073] 3) Then apply the aqueous solution formed by the composition in Table 1 and purified water in sequence. Apply 2 mg / cm2 twice a day. 2 ; On the 5th day, observe whether there is any skin reaction.

[0074] Table 1 Composition patch results

[0075]

[0076] As can be seen from Table 1, 24 hours after the patch application, it was found that the test group that applied the aqueous solution of the composition had no skin reaction, no redness or erythema, etc.

[0077] Example 5 Investigation of the effect of the composition on relieving skin allergies

[0078] This Example 5 prepares a composition with scalp care efficacy, prepares the composition and culture medium into experimental culture medium containing different concentrations of the composition, and then inoculates and cultures human immortalized epidermal cells (HaCaT cells) in the experimental culture medium, respectively, and observes the activity of HaCaT cells to detect the inhibition of cell death induced by sodium dodecyl sulfate (SLS) by compositions of different concentrations, so as to investigate the efficacy of the composition in relieving skin allergies caused by surfactants. It includes the following:

[0079] SLS can cause irreversible damage to cells, leading to cell breakage and cell DNA damage, and in severe cases, it can even induce cell apoptosis. SLS was applied to HaCaT cells, and the cell activity was detected by the MTT colorimetric method.

[0080] 5.1. Preparation of a composition having scalp care efficacy

[0081] 0.3 parts by weight of piroctone olamine salt, 0.1 parts by weight of citric acid and 0.15 parts by weight of sarcosine are mixed to obtain a composition having scalp care efficacy.

[0082] 5.2. Cultivation of HaCaT cells

[0083] HaCaT cells were routinely cultured with DMEM complete medium (containing 10% fetal bovine serum and 1% penicillin-streptomycin double antibody) in an incubator at 37°C, 5% CO2, and saturated humidified air. Cells in the logarithmic growth phase were inoculated in 96-well culture plates.

[0084] 5.3 Experimental Group Design

[0085] Experimental group: Prepare culture medium containing different concentrations of the composition. Specifically, first mix the composition with DMEM culture medium to prepare an experimental culture medium with a concentration of 25 μg / mL; then use DMEM culture medium to dilute to a concentration gradient of 10 μg / mL, 4 μg / mL, 1.6 μg / mL and 0.64 μg / mL. That is, a total of 5 concentration gradient test groups are set up. Concentration here refers to the ratio of the mass of the composition to the volume of the culture medium. For example, an experimental culture medium of 25 μg / mL refers to a mixture of 2.5 g of the composition and 100 mL of the culture medium.

[0086] Control group: a positive control group with only 1 wt% SLS solution, a negative control group with cells and DMEM medium, and a blank control group with no cells and only DMEM medium were set up.

[0087] The positive control group was a mixture of SLS solution and DMEM culture medium, that is, 1 wt % SLS aqueous solution and DMEM culture medium were mixed in a mass ratio of 1:1.

[0088] Six parallel wells were set up for each group and the experiment was repeated 3 times.

[0089] 5.3 Cell experiments

[0090] 1) Add 50 μL of experimental culture medium to the 96-well plate prepared in step 5.2, and then add 50 μL of 1 wt% SLS aqueous solution.

[0091] 2) Then place the 96-well plate in an incubator at 37°C, 5% CO2, and saturated humidified air for 24 hours.

[0092] 3) After washing HaCaT cells with PBS buffer, serum-free DMEM medium was added, followed by 5 mg / mL MTT solution. After incubation in the incubator for 3 hours in the dark, the original medium was discarded, and 150 μL DMSO solution was directly added to the 96-well plate. The plate was placed on a shaker and fully shaken at room temperature for 15 minutes. The absorbance value (OD value) at 490 nm was measured by an ELISA reader. The blank well background was deducted from the relevant values. The results are shown in Table 2.

[0093] Cell activity = [(experimental group or positive control group - blank group) / (negative control group - blank group)] * 100%

[0094] Table 2 Cell activity of HaCaT cells after the combination and SLS acted together

[0095] Group (μg / ml) <![CDATA[OD 490 Value]]> HaCaT cell activity (%) Negative control group 1.632 100 25 1.561 95.65 10 1.471 90.13 4 1.255 76.90 1.6 1.106 67.77 0.64 1.028 62.99 Positive control group 0.7444 45.61

[0096] From Table 2, the test groups added with different concentrations of the composition have higher cell activity than the positive control group, which can significantly alleviate cell damage and relieve the stimulation caused by SLS.

[0097] Example 6 Composition to form a cleansing product and investigate the oil control effect

[0098] In this Example 6, the composition and other auxiliary materials are formed into a washing and care product (shampoo) to investigate the oil control effect.

[0099] 6.1. Group settings

[0100] Common shampoo was used as a matrix and mixed with the compositions of Comparative Examples 1-3 and Example 4, respectively. The specific formula is shown in Table 3, and a washing and care product (in the form of shampoo) was prepared. Then, the oil control effect of the shampoo was examined.

[0101] Table 3 Shampoo ingredient formula of Example 4 and Comparative Examples 1-3 (wt%)

[0102] Recipe Ingredients Comparative Example 1 Comparative Example 2 Comparative Example 3 Example 4 EDTA-2NA (Ethylenediaminetetraacetic acid disodium) 0.1 0.1 0.1 0.1 Polyquaternium-10 (Cationic Cellulose) 0.3 0.3 0.3 0.3 Sodium Cocoyl Isethionate 10.0 10.0 10.0 10.0 Cocamidopropyl Betaine 25.0 25.0 25.0 25.0 Sodium Benzoate 0.4 0.4 0.4 0.4 Phenoxyethanol 0.5 0.5 0.5 0.5 Piroctone olamine — 0.3 0.3 0.3 Citric acid 0.1 — 0.1 0.1 Creatine 0.15 0.15 — 0.15 Purified water To 100 To 100 To 100 To 100

[0103] 6.2. Evaluation of oil control efficacy

[0104] Test method: According to the inclusion and exclusion criteria of the human efficacy test, voluntary subjects were recruited, and the principle of before and after control was adopted. 120 people were randomly divided into 4 groups. On the day of the 0-week visit test, after balancing for 20 minutes under the standard test environment, the skin oil content of the test area was measured using a skin oil tester (SM815). Each time you use it, wet your hair thoroughly, take 15mL of the sample and apply it evenly to the scalp, gently massage for 1-2 minutes, and rinse with clean water. Use the same method to blow dry your hair. After using the product for 4 weeks continuously, visit the site and test the oil content of the skin again. By statistically analyzing the oil content of the skin before and after the use of Example 4 and Comparative Examples 1-3 (4 weeks), the oil control efficacy of the shampoo and care product was evaluated. The results are shown in Table 4.

[0105] Table 4 Statistical analysis results of oil content before and after use

[0106] Grouping <![CDATA[Mean (μg / cm 2 ) - Initial value (T0)]]> <![CDATA[Mean (μg / cm 2 ) - Using sample for 4 weeks (T4)]]> Downward adjustment rate P-value Significance Comparative Example 1 135.43±28.03 84.01±22.63 37.97% <0.0001 **** Comparative Example 2 126.63±31.23 105.45±24.04 16.73% <0.0001 **** Comparative Example 3 129.15±25.47 66.56±22.93 48.46% <0.0001 **** Example 4 124.35±27.71 45.78±18.14 63.18% <0.0001 ****

[0107] Figure 1 This is a comparison picture of one of the volunteers before and after use.

[0108] from Figure 1 It can be seen that before use, the scalp has vigorous oil secretion and a large amount of oil is attached; after use, the scalp becomes clean and refreshed.

[0109] Table 4 and Figure 2 The oil content values ​​of the skin in each group of tests were listed, and t-test analysis was performed on this parameter using GraphPad Prism 8.0. The results showed that the oil content after using the samples for 4 weeks was significantly different from the initial value (i.e. before use), and the shampoo containing the composition of Example 4 had the highest reduction rate.

[0110] Example 7 Composition forms cleansing product and investigates oil control efficacy

[0111] In this Example 7, the composition and other auxiliary materials are combined to form a hair care product (hair care essence) to investigate the oil control effect.

[0112] Excessive sebum secretion is the main factor causing various skin problems such as acne, and the main factor affecting sebum secretion is the disorder of hormone levels in the body. Sebaceous gland cells synthesize a large amount of oil and secrete it outside the cells in the form of lipid droplets, affecting cell function and causing various skin problems. The amount of lipid droplets is the main indicator for measuring the degree of oil control. Therefore, this test evaluates the oil control effect of the cleaning product by detecting the lipid droplet content of sebaceous gland cells after the sample is acted on.

[0113] 7.1. Group settings

[0114] A common hair care essence was used as a matrix and mixed with the compositions of Comparative Examples 1-3 and Example 4, respectively. The specific formula is shown in Table 5, and a hair care product (in the form of a hair care essence) was prepared. The oil control effect of the hair care product was then examined.

[0115] Table 5 Hair care essence ingredient formula of Example 4 and Comparative Examples 1-3 (wt%)

[0116] Recipe Ingredients Comparative Example 1 Comparative Example 2 Comparative Example 3 Example 4 Hydroxyethyl Cellulose 0.3 0.3 0.3 0.3 glycerin 2 2 2 2 Panthenol 0.2 0.2 0.2 0.2 Menthyl Lactate 0.1 0.1 0.1 0.1 Alcohol 15 15 15 15 Pentylene glycol 2 2 2 2 p-Hydroxyacetophenone 0.4 0.4 0.4 0.4 1,2-Hexanediol 0.5 0.5 0.5 0.5 Piroctone olamine - 0.3 0.3 0.3 Citric acid 0.1 - 0.1 0.1 Creatine 0.15 0.15 - 0.15 Purified water To 100 To 100 To 100 To 100

[0117] 7.2. Evaluation of Oil Control Efficacy

[0118] 1) Cell seeding: 3.5×10 4 SZ95 cells were inoculated into 24-well plates at a density of 10 cells / well and incubated in an incubator (37°C, 5% CO2) for 16 h.

[0119] 2) Drug administration: According to the hair care essence obtained in Table 5, when the cell plating rate in the 24-well plate reaches 60%-70%, the drug administration is carried out separately, with 1 mL of hair care essence added to each well, and 6 replicate wells are set up for each group.

[0120] 3) Oil Red O staining: discard the old solution, wash the cells once with PBS, add 500 μL of Oil Red O working solution (1 μg / mL) to each well, stain for 15 min in the dark (incubate at 37°C), wash twice with PBS, and detect lipid droplet synthesis by Oil Red O staining. Oil Red O staining method reference 1 (Shi Ge, Wang Tingting. Effects of short-wave ultraviolet irradiation on sebum secretion of sebaceous gland cells [J]. Journal of Guangdong Medical College, 2016, 34(4): 370-377).

[0121] A blank control group was set up, which was different from Example 4 and Comparative Examples 1-3 in that 1 mL of distilled water was added in step 2) instead of adding hair care essence, and the other conditions were the same.

[0122] The comparison among the groups was performed using one-way analysis of variance, with a test level of α = 0.05, P < 0.05 was considered to be significantly different, and P < 0.01 was considered to be extremely significantly different. The results are shown in Table 6, and the graphs were drawn using GraphPad Prism 8.0. Figure 3 .

[0123] Table 6 Results of lipid droplet synthetic Oil Red O staining

[0124] Group Relative IOD value (mean) SD (standard deviation) P-value Blank control group 1.000 0.065 Comparative Example 1 0.780 0.047 <0.0001 Comparative Example 2 0.850 0.054 0.0211 Comparative Example 3 0.750 0.042 <0.0001 Example 4 0.660 0.048 <0.0001

[0125] Sebaceous gland cells synthesize a large amount of oil and secrete it outside the cells in the form of lipid droplets, which affects cell function and causes a variety of skin problems. The amount of lipid droplets is the main indicator to measure the degree of oil control.

[0126] from Figure 3As shown in Table 6, compared with Comparative Examples 1-3 and the control group, the relative IOD values ​​of Example 4 are significantly reduced, indicating that the cleaning product of the present application can have a good oil control effect.

[0127] The above embodiments are merely illustrative of the principles and effects of the present invention, and are not intended to limit the present invention. Anyone familiar with the art may modify or alter the above embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or alterations made by a person of ordinary skill in the art without departing from the spirit and technical concept disclosed by the present invention shall still be covered by the claims of the present invention.

Claims

1. A composition having scalp care efficacy, characterized in that: The composition comprises the following raw materials in parts by weight: Piroctone ethanolamine salt 0.01~1 part Citric acid 0.0001~3 parts Sarcosine 0.0001 to 1 part.

2. Use of the composition as claimed in claim 1 as a raw material in the preparation of cleaning products.

3. The use according to claim 2, characterized in that The hair care product is selected from at least one of shampoo, hair care essence, hair conditioner, hair mask and hair care spray.

4. A cleaning product, characterized in that: The cleaning product comprises the composition according to claim 1.

5. The cleaning product according to claim 4, characterized in that: Also includes one or more of non-sulfate surfactants, chelating agents, conditioning agents, preservatives and solvents; And / or, the cleaning product is shampoo; Preferably, the non-sulfate surfactant is selected from one or both of sodium cocoyl isethionate and cocamidopropyl betaine; Preferably, the chelating agent is selected from disodium ethylenediaminetetraacetate; Preferably, the conditioning agent is selected from polyquaternium-10; Preferably, the preservative is selected from one or both of sodium benzoate and phenoxyethanol; Preferably, the solvent is selected from water.

6. The cleaning product according to claim 4, characterized in that: Also includes one or more of a thickener, a humectant, a cooling agent, an antioxidant and a solvent; And / or, the cleaning product is a hair care essence; Preferably, the thickener is selected from hydroxyethyl cellulose; Preferably, the humectant is selected from one or more of glycerol, panthenol, pentylene glycol and 1,2-hexanediol; Preferably, the cooling agent is selected from menthol lactate; Preferably, the antioxidant is selected from p-hydroxyacetophenone; Preferably, the solvent is selected from ethanol.

7. Use of the composition according to claim 1 or the care product according to claim 4 in scalp care.

8. The use according to claim 2 or 7, characterized in that The scalp care refers to alleviating scalp allergies or controlling oil.

9. The use according to claim 8, characterized in that The scalp allergy is caused by surfactants.

10. The use according to claim 9, characterized in that The surfactant is selected from one or more of sodium dodecyl sulfate, sodium lauryl sulfate, sodium dodecyl sulfate and sodium dodecyl ether sulfate.

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