Medicament for treating dyspepsia and preparation process thereof

Abstract

The invention discloses a treatment medicament for dyspepsia and a preparation process thereof, and is characterized in that the treatment medicament is prepared from the following raw material medicines: 20-40 parts of codonopsis pilosula, 10-20 parts of poria cocos, 5-10 parts of bighead atractylodes rhizome, 13-20 parts of immature bitter orange, 30-50 parts of pericarpium citri reticulatae, 5-10 parts of ginger, 10-15 parts of scutellaria baicalensis, 10-15 parts of coptis chinensis, 12-18 parts of golden cypress and 10-15 parts of gardenia, and the invention relates to the technical field of medicine and pharmacy. The medicament for treating dyspepsia and the preparation process thereof have the effects of appetizing, eliminating flatulence, invigorating spleen, replenishing qi, inducing diuresis and regulating qi, and can regulate the spleen and stomach of a patient, so that the dyspepsia of the patient can be treated fundamentally, and the condition of repeated attack of diseases is avoided.

Description

Technical Field

[0001] The invention relates to the technical field of medicine and pharmaceuticals, and in particular to a therapeutic agent for indigestion and a preparation process thereof. Background Art

[0002] Dyspepsia is a common and frequently-occurring disease of the digestive system in internal medicine. There are many people with the disease, and there is no obvious regional and temporal difference in the incidence rate in various places. The disease is called "piman syndrome", "food stagnation" and "diarrhea" in traditional Chinese medicine. The clinical manifestations are fullness or distending pain in the abdomen, liver and stomach stagnation, liver and stomach qi stagnation, poor appetite, warm air, loose stools or poor defecation, etc., which are common in children, the elderly and postoperative patients. This disease involves a wide range of people, and often requires long-term and repeated medication, long treatment time and high cost. At present, there are some conventional Western medicines for treating this disease at home and abroad, such as metoclopramide (domperidone), prebos, cisapride, metoclopramide, etc., which have certain good effects, but the condition is easy to recur and has certain side effects. For example, the side effects of metoclopramide (domperidone) on the central nervous system and extrapyramidal system, and cisapride can cause loose stools and diarrhea, etc., and the long-term efficacy of these Western medicines needs to be improved. In the past, traditional Chinese medicine theory believed that it was mainly caused by weak spleen and stomach. In recent years, modern medical research has found that insufficient gastrointestinal motility causing slow gastrointestinal motility is its main pathogenesis.

[0003] The drugs currently used to treat indigestion are usually less effective, can only treat the symptoms but not the root cause, and cannot nourish the patient's spleen and stomach. Summary of the invention

[0004] To achieve the above objectives, the present invention is implemented through the following technical scheme: a therapeutic agent for indigestion and its production process, characterized in that it is composed of the following raw materials, including: 20-40 parts of Codonopsis pilosula, 10-20 parts of Poria cocos, 5-10 parts of Atractylodes macrocephala, 13-20 parts of Citrus aurantium, 30-50 parts of dried tangerine peel, 5-10 parts of ginger, 10-15 parts of Scutellaria baicalensis, 10-15 parts of Coptis chinensis, 12-18 parts of Phellodendron chinense, and 10-15 parts of Gardenia jasminoides.

[0005] Preferably, the optimal dosage ratio of the therapeutic agent is 30 parts of Codonopsis pilosula, 15 parts of Poria cocos, 7 parts of Atractylodes macrocephala, 17 parts of Citrus aurantium, 40 parts of Tangerine peel, 7 parts of ginger, 13 parts of Scutellaria baicalensis, 13 parts of Coptis chinensis, 15 parts of Phellodendron chinense, and 13 parts of Gardenia jasminoides.

[0006] A process for preparing a therapeutic agent for indigestion, comprising the following steps:

[0007] Step 1: Prepare medicinal extract:

[0008] S1. Take the prescribed amount of each medicinal material and put it into the cleaning equipment to clean it, and then air dry it naturally for 3-5 hours;

[0009] S2, putting the air-dried medicinal materials in step S1 into an extraction tank, adding 6-8 times the amount of water, and heating to reflux;

[0010] S3, filtering the material after heating and reflux in step S2, and collecting the filtrate and the residue;

[0011] S4, add 5-7 times the amount of water to the extraction tank, and heat to reflux;

[0012] S5, filtering the material after heating and reflux in step S4, collecting the filtrate, and combining the filtrate with the filtrate in step S3;

[0013] S6, placing the mixed filtrate in step S5 into a concentration tank for reduced pressure concentration;

[0014] S7, under stirring, add 90% ethanol to the concentrated liquid medicine until the ethanol content reaches 60%, and put it into a cold storage for refrigeration;

[0015] S8, performing plate-and-frame filtration on the liquid medicine after refrigeration in step S7 to obtain an alcohol precipitation filtrate;

[0016] S9, adding the alcohol precipitation filtrate in step S8 into a concentration tank for reduced pressure concentration to obtain an extract;

[0017] S10, placing the extract in step S9 into a vacuum drying device for vacuum drying to obtain a dry extract;

[0018] Step 2: Preparation of granules:

[0019] A1. Grind the dry extract in step S10 and pass it through a 5-mesh sieve;

[0020] A2, take 5-10 parts of sodium carboxymethyl starch, 10-20 parts of dextrin and lactose, grind them separately and pass them through a 60-mesh sieve, then mix them with 10-20 parts of stevioside, stir and mix, and pass them through a 60-mesh sieve to obtain a mixed auxiliary material;

[0021] A3, putting the dry paste powder in step A1 and the mixed auxiliary materials in step A2 into a mixing device and mixing them evenly to obtain a mixture;

[0022] A4, adding 70% ethanol to the mixed material in step A3 at a ratio of 1:8 to obtain a finished material;

[0023] A5. The finished product in step A4 is sieved through a 12-mesh sieve for granulation. The wet granules are placed in a drying oven, ventilated and dried, and then sieved through a 12-mesh sieve for granulation;

[0024] A6. Continue drying the particles in step A5 at 55° C. for 6 hours to obtain finished particles.

[0025] Preferably, the heating reflux time in step S2 is 3-5 hours and the temperature is 50-60°C.

[0026] Preferably, the heating reflux time in step S4 is 2-4 hours and the temperature is 55-65°C.

[0027] Preferably, the reduced pressure concentration temperature in step S6 is maintained at 70-80° C., and the reduced pressure concentration is performed until the relative density reaches 1.12 to 1.14.

[0028] Preferably, the refrigeration temperature in step S7 is 2° C. and the refrigeration time is 18 hours.

[0029] Preferably, the reduced pressure concentration temperature in step S9 is maintained at 40-50° C., and the reduced pressure concentration is performed to a density of 1.24-1.26.

[0030] Preferably, the vacuum drying temperature in step 10 is 40-50° C., and the vacuum drying time is 18 hours.

[0031] Preferably, in step A5, the drying temperature is 55° C. and the ventilation drying time is 40 minutes.

[0032] The present invention provides a therapeutic agent for indigestion and a preparation process thereof.

[0033] Beneficial effects:

[0034] The production process of the therapeutic agent for indigestion has the effects of stimulating appetite and eliminating bloating, strengthening the spleen and replenishing qi, promoting diuresis and regulating qi, and can regulate the spleen and stomach of patients, thereby facilitating the fundamental treatment of patients' indigestion and avoiding recurrence of symptoms. DETAILED DESCRIPTION

[0035] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0036] In the first embodiment, the present invention provides a technical solution: a process for preparing a therapeutic agent for indigestion, comprising the following steps:

[0037] Step 1: Prepare medicinal extract:

[0038] S1, take 20 parts of Codonopsis pilosula, 10 parts of Poria cocos, 5 parts of Atractylodes macrocephala, 13 parts of Citrus aurantium, 30 parts of dried tangerine peel, 5 parts of ginger, 10 parts of Scutellaria baicalensis, 10 parts of Coptis chinensis, 12 parts of Phellodendron chinense, and 10 parts of Gardenia jasminoides, put each medicinal material into a cleaning device, clean it, and then air-dry it naturally for 3 hours;

[0039] S2, putting the air-dried medicinal materials in step S1 into an extraction tank, adding 6 times the amount of water, heating and reflux, the heating and reflux time is 3 hours, and the temperature is 50°C;

[0040] S3, filtering the material after heating and reflux in step S2, and collecting the filtrate and the residue;

[0041] S4, add 5 times the amount of water to the extraction tank, heat and reflux, the heating and reflux time is 2 hours, the temperature is 55 ° C;

[0042] S5, filtering the material after heating and reflux in step S4, collecting the filtrate, and combining the filtrate with the filtrate in step S3;

[0043] S6, placing the mixed filtrate in step S5 into a concentration tank for vacuum concentration, maintaining the vacuum concentration temperature at 70° C., and vacuum concentration until the relative density reaches 1.12;

[0044] S7, under stirring, add 90% ethanol to the concentrated drug solution until the ethanol content is 60%, and put it into a cold storage for refrigeration at a temperature of 2°C for 18 hours;

[0045] S8, performing plate-and-frame filtration on the liquid medicine after refrigeration in step S7 to obtain an alcohol precipitation filtrate;

[0046] S9, adding the alcohol precipitation filtrate in step S8 into a concentration tank for vacuum concentration to obtain an extract, maintaining the vacuum concentration temperature at 40° C. and vacuum concentrating to a density of 1.24;

[0047] S10, placing the extract in step S9 into a vacuum drying device for vacuum drying to obtain a dry extract, the vacuum drying temperature is 40° C., and the vacuum drying time is 18 hours;

[0048] Step 2: Preparation of granules:

[0049] A1. Grind the dry extract in step S10 and pass it through a 5-mesh sieve;

[0050] A2, take 6 parts of sodium carboxymethyl starch, 12 parts of dextrin and lactose, grind them separately and pass them through a 60-mesh sieve, then mix them with 12 parts of stevioside, stir and mix, and pass them through a 60-mesh sieve to obtain a mixed auxiliary material;

[0051] A3, putting the dry paste powder in step A1 and the mixed auxiliary materials in step A2 into a mixing device and mixing them evenly to obtain a mixture;

[0052] A4, adding 70% ethanol to the mixed material in step A3 at a ratio of 1:8 to obtain a finished material;

[0053] A5. The finished material in step A4 is sieved through a 12-mesh sieve for granulation. The wet granules are placed in a drying oven, ventilated and dried, and then sieved through a 12-mesh sieve for granulation. The drying temperature is 55° C. and the ventilated drying time is 40 minutes.

[0054] A6. Continue drying the particles in step A5 at 55° C. for 6 hours to obtain finished particles.

[0055] In the second embodiment, the present invention provides a technical solution: a process for preparing a therapeutic agent for indigestion, comprising the following steps:

[0056] Step 1: Prepare medicinal extract:

[0057] S1, take 24 parts of Codonopsis pilosula, 12 parts of Poria cocos, 6 parts of Atractylodes macrocephala, 15 parts of Citrus aurantium, 34 parts of Citrus reticulata, 6 parts of ginger, 11 parts of Scutellaria baicalensis, 11 parts of Coptis chinensis, 13 parts of Phellodendron amurense, and 11 parts of Gardenia jasminoides, put each medicinal material into a cleaning device, clean it, and then air-dry it naturally for 3-5 hours;

[0058] S2, putting the air-dried medicinal materials in step S1 into an extraction tank, adding 6 times the amount of water, heating and reflux, the heating and reflux time is 3 hours, and the temperature is 50°C;

[0059] S3, filtering the material after heating and reflux in step S2, and collecting the filtrate and the residue;

[0060] S4, add 5 times the amount of water to the extraction tank, heat and reflux, the heating and reflux time is 2 hours, the temperature is 55 ° C;

[0061] S5, filtering the material after heating and reflux in step S4, collecting the filtrate, and combining the filtrate with the filtrate in step S3;

[0062] S6, placing the mixed filtrate in step S5 into a concentration tank for vacuum concentration, maintaining the vacuum concentration temperature at 70° C., and vacuum concentration until the relative density reaches 1.12;

[0063] S7, under stirring, add 90% ethanol to the concentrated drug solution until the ethanol content is 60%, and put it into a cold storage for refrigeration at a temperature of 2°C for 18 hours;

[0064] S8, performing plate-and-frame filtration on the liquid medicine after refrigeration in step S7 to obtain an alcohol precipitation filtrate;

[0065] S9, adding the alcohol precipitation filtrate in step S8 into a concentration tank for vacuum concentration to obtain an extract, maintaining the vacuum concentration temperature at 40° C. and vacuum concentrating to a density of 1.24;

[0066] S10, placing the extract in step S9 into a vacuum drying device for vacuum drying to obtain a dry extract, the vacuum drying temperature is 40° C., and the vacuum drying time is 18 hours;

[0067] Step 2: Preparation of granules:

[0068] A1. Grind the dry extract in step S10 and pass it through a 5-mesh sieve;

[0069] A2, take 6 parts of sodium carboxymethyl starch, 12 parts of dextrin and lactose, grind them separately and pass them through a 60-mesh sieve, then mix them with 12 parts of stevioside, stir and mix, and pass them through a 60-mesh sieve to obtain a mixed auxiliary material;

[0070] A3, putting the dry paste powder in step A1 and the mixed auxiliary materials in step A2 into a mixing device and mixing them evenly to obtain a mixture;

[0071] A4, adding 70% ethanol to the mixed material in step A3 at a ratio of 1:8 to obtain a finished material;

[0072] A5. The finished material in step A4 is sieved through a 12-mesh sieve for granulation. The wet granules are placed in a drying oven, ventilated and dried, and then sieved through a 12-mesh sieve for granulation. The drying temperature is 55° C. and the ventilated drying time is 40 minutes.

[0073] A6. Continue drying the particles in step A5 at 55° C. for 6 hours to obtain finished particles.

[0074] In a third embodiment, the present invention provides a technical solution: a process for preparing a therapeutic agent for indigestion, comprising the following steps:

[0075] Step 1: Prepare medicinal extract:

[0076] S1, take 28 parts of Codonopsis pilosula, 14 parts of Poria cocos, 7 parts of Atractylodes macrocephala, 16 parts of Citrus aurantium, 38 parts of dried orange peel, 7 parts of ginger, 12 parts of Scutellaria baicalensis, 12 parts of Coptis chinensis, 14 parts of Phellodendron chinense, and 12 parts of Gardenia jasminoides, put each medicinal material into a cleaning device, clean it, and then air-dry it naturally for 3 hours;

[0077] S2, putting the air-dried medicinal materials in step S1 into an extraction tank, adding 6 times the amount of water, heating and reflux, the heating and reflux time is 3 hours, and the temperature is 50°C;

[0078] S3, filtering the material after heating and reflux in step S2, and collecting the filtrate and the residue;

[0079] S4, add 5 times the amount of water to the extraction tank, heat and reflux, the heating and reflux time is 2 hours, the temperature is 55 ° C;

[0080] S5, filtering the material after heating and reflux in step S4, collecting the filtrate, and combining the filtrate with the filtrate in step S3;

[0081] S6, placing the mixed filtrate in step S5 into a concentration tank for vacuum concentration, maintaining the vacuum concentration temperature at 70° C., and vacuum concentration until the relative density reaches 1.12;

[0082] S7, under stirring, add 90% ethanol to the concentrated drug solution until the ethanol content is 60%, and put it into a cold storage for refrigeration at a temperature of 2°C for 18 hours;

[0083] S8, performing plate-and-frame filtration on the liquid medicine after refrigeration in step S7 to obtain an alcohol precipitation filtrate;

[0084] S9, adding the alcohol precipitation filtrate in step S8 into a concentration tank for vacuum concentration to obtain an extract, maintaining the vacuum concentration temperature at 40° C. and vacuum concentrating to a density of 1.24;

[0085] S10, placing the extract in step S9 into a vacuum drying device for vacuum drying to obtain a dry extract, the vacuum drying temperature is 40° C., and the vacuum drying time is 18 hours;

[0086] Step 2: Preparation of granules:

[0087] A1. Grind the dry extract in step S10 and pass it through a 5-mesh sieve;

[0088] A2, take 6 parts of sodium carboxymethyl starch, 12 parts of dextrin and lactose, grind them separately and pass them through a 60-mesh sieve, then mix them with 12 parts of stevioside, stir and mix, and pass them through a 60-mesh sieve to obtain a mixed auxiliary material;

[0089] A3, putting the dry paste powder in step A1 and the mixed auxiliary materials in step A2 into a mixing device and mixing them evenly to obtain a mixture;

[0090] A4, adding 70% ethanol to the mixed material in step A3 at a ratio of 1:8 to obtain a finished material;

[0091] A5. The finished material in step A4 is sieved through a 12-mesh sieve for granulation. The wet granules are placed in a drying oven, ventilated and dried, and then sieved through a 12-mesh sieve for granulation. The drying temperature is 55° C. and the ventilated drying time is 40 minutes.

[0092] A6. Continue drying the particles in step A5 at 55° C. for 6 hours to obtain finished particles.

[0093] In a fourth embodiment, the present invention provides a technical solution: a process for preparing a therapeutic agent for indigestion, comprising the following steps:

[0094] Step 1: Prepare medicinal extract:

[0095] S1, take 32 parts of Codonopsis pilosula, 16 parts of Poria cocos, 8 parts of Atractylodes macrocephala, 17 parts of Citrus aurantium, 42 parts of Citrus reticulata, 8 parts of ginger, 13 parts of Scutellaria baicalensis, 13 parts of Coptis chinensis, 16 parts of Phellodendron chinense, and 13 parts of Gardenia jasminoides, put each medicinal material into a cleaning device, clean it, and then air-dry it naturally for 3 hours;

[0096] S2, putting the air-dried medicinal materials in step S1 into an extraction tank, adding 6 times the amount of water, heating and reflux, the heating and reflux time is 3 hours, and the temperature is 50°C;

[0097] S3, filtering the material after heating and reflux in step S2, and collecting the filtrate and the residue;

[0098] S4, add 5 times the amount of water to the extraction tank, heat and reflux, the heating and reflux time is 2 hours, the temperature is 55 ° C;

[0099] S5, filtering the material after heating and reflux in step S4, collecting the filtrate, and combining the filtrate with the filtrate in step S3;

[0100] S6, placing the mixed filtrate in step S5 into a concentration tank for vacuum concentration, maintaining the vacuum concentration temperature at 70° C., and vacuum concentration until the relative density reaches 1.12;

[0101] S7, under stirring, add 90% ethanol to the concentrated drug solution until the ethanol content is 60%, and put it into a cold storage for refrigeration at a temperature of 2°C for 18 hours;

[0102] S8, performing plate-and-frame filtration on the liquid medicine after refrigeration in step S7 to obtain an alcohol precipitation filtrate;

[0103] S9, adding the alcohol precipitation filtrate in step S8 into a concentration tank for vacuum concentration to obtain an extract, maintaining the vacuum concentration temperature at 40° C. and vacuum concentrating to a density of 1.24;

[0104] S10, placing the extract in step S9 into a vacuum drying device for vacuum drying to obtain a dry extract, the vacuum drying temperature is 40° C., and the vacuum drying time is 18 hours;

[0105] Step 2: Preparation of granules:

[0106] A1. Grind the dry extract in step S10 and pass it through a 5-mesh sieve;

[0107] A2, take 6 parts of sodium carboxymethyl starch, 12 parts of dextrin and lactose, grind them separately and pass them through a 60-mesh sieve, then mix them with 12 parts of stevioside, stir and mix, and pass them through a 60-mesh sieve to obtain a mixed auxiliary material;

[0108] A3, putting the dry paste powder in step A1 and the mixed auxiliary materials in step A2 into a mixing device and mixing them evenly to obtain a mixture;

[0109] A4, adding 70% ethanol to the mixed material in step A3 at a ratio of 1:8 to obtain a finished material;

[0110] A5. The finished material in step A4 is sieved through a 12-mesh sieve for granulation. The wet granules are placed in a drying oven, ventilated and dried, and then sieved through a 12-mesh sieve for granulation. The drying temperature is 55° C. and the ventilated drying time is 40 minutes.

[0111] A6. Continue drying the particles in step A5 at 55° C. for 6 hours to obtain finished particles.

[0112] In a fifth embodiment, the present invention provides a technical solution: a process for preparing a therapeutic agent for indigestion, comprising the following steps:

[0113] Step 1: Prepare medicinal extract:

[0114] S1, take 40 parts of Codonopsis pilosula, 20 parts of Poria cocos, 10 parts of Atractylodes macrocephala, 20 parts of Citrus aurantium, 50 parts of dried tangerine peel, 10 parts of ginger, 15 parts of Scutellaria baicalensis, 15 parts of Coptis chinensis, 18 parts of Phellodendron chinense, and 15 parts of Gardenia jasminoides, put each medicinal material into a cleaning device, clean it, and then air-dry it naturally for 3 hours;

[0115] S2, putting the air-dried medicinal materials in step S1 into an extraction tank, adding 6 times the amount of water, heating and reflux, the heating and reflux time is 3 hours, and the temperature is 50°C;

[0116] S3, filtering the material after heating and reflux in step S2, and collecting the filtrate and the residue;

[0117] S4, add 5 times the amount of water to the extraction tank, heat and reflux, the heating and reflux time is 2 hours, the temperature is 55 ° C;

[0118] S5, filtering the material after heating and reflux in step S4, collecting the filtrate, and combining the filtrate with the filtrate in step S3;

[0119] S6, placing the mixed filtrate in step S5 into a concentration tank for vacuum concentration, maintaining the vacuum concentration temperature at 70° C., and vacuum concentration until the relative density reaches 1.12;

[0120] S7, under stirring, add 90% ethanol to the concentrated drug solution until the ethanol content is 60%, and put it into a cold storage for refrigeration at a temperature of 2°C for 18 hours;

[0121] S8, performing plate-and-frame filtration on the liquid medicine after refrigeration in step S7 to obtain an alcohol precipitation filtrate;

[0122] S9, adding the alcohol precipitation filtrate in step S8 into a concentration tank for vacuum concentration to obtain an extract, maintaining the vacuum concentration temperature at 40° C. and vacuum concentrating to a density of 1.24;

[0123] S10, placing the extract in step S9 into a vacuum drying device for vacuum drying to obtain a dry extract, the vacuum drying temperature is 40° C., and the vacuum drying time is 18 hours;

[0124] Step 2: Preparation of granules:

[0125] A1. Grind the dry extract in step S10 and pass it through a 5-mesh sieve;

[0126] A2, take 6 parts of sodium carboxymethyl starch, 12 parts of dextrin and lactose, grind them separately and pass them through a 60-mesh sieve, then mix them with 12 parts of stevioside, stir and mix, and pass them through a 60-mesh sieve to obtain a mixed auxiliary material;

[0127] A3, putting the dry paste powder in step A1 and the mixed auxiliary materials in step A2 into a mixing device and mixing them evenly to obtain a mixture;

[0128] A4, adding 70% ethanol to the mixed material in step A3 at a ratio of 1:8 to obtain a finished material;

[0129] A5. The finished material in step A4 is sieved through a 12-mesh sieve for granulation. The wet granules are placed in a drying oven, ventilated and dried, and then sieved through a 12-mesh sieve for granulation. The drying temperature is 55° C. and the ventilated drying time is 40 minutes.

[0130] A6. Continue drying the particles in step A5 at 55° C. for 6 hours to obtain finished particles.

[0131] In a sixth embodiment, the present invention provides a technical solution: a process for preparing a therapeutic agent for indigestion, comprising the following steps:

[0132] Step 1: Prepare medicinal extract:

[0133] S1, take 40 parts of Codonopsis pilosula, 20 parts of Poria cocos, 10 parts of Atractylodes macrocephala, 20 parts of Citrus aurantium, 50 parts of dried tangerine peel, 10 parts of ginger, 15 parts of Scutellaria baicalensis, 15 parts of Coptis chinensis, 18 parts of Phellodendron chinense, and 15 parts of Gardenia jasminoides, put each medicinal material into a cleaning device, clean it, and then air-dry it naturally for 3 hours;

[0134] S2, putting the air-dried medicinal materials in step S1 into an extraction tank, adding 8 times the amount of water, heating and reflux, the heating and reflux time is 5 hours, and the temperature is 60°C;

[0135] S3, filtering the material after heating and reflux in step S2, and collecting the filtrate and the residue;

[0136] S4, add 7 times the amount of water to the extraction tank, heat and reflux, the heating and reflux time is 4 hours, the temperature is 65 ° C;

[0137] S5, filtering the material after heating and reflux in step S4, collecting the filtrate, and combining the filtrate with the filtrate in step S3;

[0138] S6, placing the mixed filtrate in step S5 into a concentration tank for vacuum concentration, maintaining the vacuum concentration temperature at 80° C., and vacuum concentration until the relative density reaches 1.14;

[0139] S7, under stirring, add 90% ethanol to the concentrated drug solution until the ethanol content is 60%, and put it into a cold storage for refrigeration at a temperature of 2°C for 18 hours;

[0140] S8, performing plate-and-frame filtration on the liquid medicine after refrigeration in step S7 to obtain an alcohol precipitation filtrate;

[0141] S9, adding the alcohol precipitation filtrate in step S8 into a concentration tank for vacuum concentration to obtain an extract, maintaining the vacuum concentration temperature at 50° C. and vacuum concentrating to a density of 1.26;

[0142] S10, placing the extract in step S9 into a vacuum drying device for vacuum drying to obtain a dry extract, the vacuum drying temperature is 50° C., and the vacuum drying time is 18 hours;

[0143] Step 2: Preparation of granules:

[0144] A1. Grind the dry extract in step S10 and pass it through a 5-mesh sieve;

[0145] A2, take 10 parts of sodium carboxymethyl starch, 20 parts of dextrin and lactose, grind them separately and pass them through a 60-mesh sieve, then mix them with 20 parts of stevioside, stir and mix, and pass them through a 60-mesh sieve to obtain a mixed auxiliary material;

[0146] A3, putting the dry paste powder in step A1 and the mixed auxiliary materials in step A2 into a mixing device and mixing them evenly to obtain a mixture;

[0147] A4, adding 70% ethanol to the mixed material in step A3 at a ratio of 1:8 to obtain a finished material;

[0148] A5. The finished material in step A4 is sieved through a 12-mesh sieve for granulation. The wet granules are placed in a drying oven, ventilated and dried, and then sieved through a 12-mesh sieve for granulation. The drying temperature is 55° C. and the ventilated drying time is 40 minutes.

[0149] A6. Continue drying the particles in step A5 at 55° C. for 6 hours to obtain finished particles.

[0150] In the seventh embodiment, the present invention provides a technical solution: a process for preparing a therapeutic agent for indigestion, comprising the following steps:

[0151] Step 1: Prepare medicinal extract:

[0152] S1, take 30 parts of Codonopsis pilosula, 15 parts of Poria cocos, 7 parts of Atractylodes macrocephala, 17 parts of Citrus aurantium, 40 parts of dried tangerine peel, 7 parts of ginger, 13 parts of Scutellaria baicalensis, 13 parts of Coptis chinensis, 15 parts of Phellodendron chinense, and 13 parts of Gardenia jasminoides, put each medicinal material into a cleaning device, clean it, and then air-dry it naturally for 3 hours;

[0153] S2, putting the air-dried medicinal materials in step S1 into an extraction tank, adding 8 times the amount of water, heating and reflux, the heating and reflux time is 5 hours, and the temperature is 60°C;

[0154] S3, filtering the material after heating and reflux in step S2, and collecting the filtrate and the residue;

[0155] S4, add 7 times the amount of water to the extraction tank, heat and reflux, the heating and reflux time is 4 hours, the temperature is 65 ° C;

[0156] S5, filtering the material after heating and reflux in step S4, collecting the filtrate, and combining the filtrate with the filtrate in step S3;

[0157] S6, placing the mixed filtrate in step S5 into a concentration tank for vacuum concentration, maintaining the vacuum concentration temperature at 80° C., and vacuum concentration until the relative density reaches 1.14;

[0158] S7, under stirring, add 90% ethanol to the concentrated drug solution until the ethanol content is 60%, and put it into a cold storage for refrigeration at a temperature of 2°C for 18 hours;

[0159] S8, performing plate-and-frame filtration on the liquid medicine after refrigeration in step S7 to obtain an alcohol precipitation filtrate;

[0160] S9, adding the alcohol precipitation filtrate in step S8 into a concentration tank for vacuum concentration to obtain an extract, maintaining the vacuum concentration temperature at 50° C. and vacuum concentrating to a density of 1.26;

[0161] S10, placing the extract in step S9 into a vacuum drying device for vacuum drying to obtain a dry extract, the vacuum drying temperature is 50° C., and the vacuum drying time is 18 hours;

[0162] Step 2: Preparation of granules:

[0163] A1. Grind the dry extract in step S10 and pass it through a 5-mesh sieve;

[0164] A2, take 10 parts of sodium carboxymethyl starch, 20 parts of dextrin and lactose, grind them separately and pass them through a 60-mesh sieve, then mix them with 20 parts of stevioside, stir and mix, and pass them through a 60-mesh sieve to obtain a mixed auxiliary material;

[0165] A3, putting the dry paste powder in step A1 and the mixed auxiliary materials in step A2 into a mixing device and mixing them evenly to obtain a mixture;

[0166] A4, adding 70% ethanol to the mixed material in step A3 at a ratio of 1:8 to obtain a finished material;

[0167] A5. The finished material in step A4 is sieved through a 12-mesh sieve for granulation. The wet granules are placed in a drying oven, ventilated and dried, and then sieved through a 12-mesh sieve for granulation. The drying temperature is 55° C. and the ventilated drying time is 40 minutes.

[0168] A6. Continue drying the particles in step A5 at 55°C for 6 hours to obtain finished particles.

[0169] After comparing the effects of the finished products of the above embodiments, it is found that the medicine prepared in the seventh embodiment has the best effect;

[0170] The best ratio of the medicine is: 30 parts of Codonopsis pilosula, 15 parts of Poria cocos, 7 parts of Atractylodes macrocephala, 17 parts of Citrus aurantium, 40 parts of Tangerine peel, 7 parts of ginger, 13 parts of Scutellaria baicalensis, 13 parts of Coptis chinensis, 15 parts of Phellodendron chinense, and 13 parts of Gardenia jasminoides.

[0171] Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field and related fields without creative work should fall within the scope of protection of the present invention. The structures, devices and operating methods not specifically described and explained in the present invention are implemented according to the conventional means in the field unless otherwise specified and limited.

Claims

1. A therapeutic agent for indigestion, characterized in that: The medicine is composed of the following raw materials: 20-40 parts of Codonopsis pilosula, 10-20 parts of Poria cocos, 5-10 parts of Atractylodes macrocephala, 13-20 parts of Citrus aurantium, 30-50 parts of Tangerine peel, 5-10 parts of Ginger, 10-15 parts of Scutellaria baicalensis, 10-15 parts of Coptis chinensis, 12-18 parts of Phellodendron amurense, and 10-15 parts of Gardenia jasminoides.

2. The therapeutic agent for indigestion according to claim 1, characterized in that: The optimal dosage ratio of the therapeutic agent is 30 parts of Codonopsis pilosula, 15 parts of Poria cocos, 7 parts of Atractylodes macrocephala, 17 parts of Citrus aurantium, 40 parts of Tangerine peel, 7 parts of ginger, 13 parts of Scutellaria baicalensis, 13 parts of Coptis chinensis, 15 parts of Phellodendron amurense, and 13 parts of Gardenia jasminoides.

3. The manufacturing process of the therapeutic agent for indigestion according to claim 2, characterized in that: The following steps are involved: Step 1: Prepare medicinal extract: S1. Take the prescribed amount of each medicinal material and put it into the cleaning equipment to clean it, and then air dry it naturally for 3-5 hours; S2, putting the air-dried medicinal materials in step S1 into an extraction tank, adding 6-8 times the amount of water, and heating to reflux; S3, filtering the material after heating and reflux in step S2, and collecting the filtrate and the residue; S4, add 5-7 times the amount of water to the extraction tank, and heat to reflux; S5, filtering the material after heating and reflux in step S4, collecting the filtrate, and combining the filtrate with the filtrate in step S3; S6, placing the mixed filtrate in step S5 into a concentration tank for reduced pressure concentration; S7, under stirring, add 90% ethanol to the concentrated liquid medicine until the ethanol content reaches 60%, and put it into a cold storage for refrigeration; S8, performing plate-and-frame filtration on the liquid medicine after refrigeration in step S7 to obtain an alcohol precipitation filtrate; S9, adding the alcohol precipitation filtrate in step S8 into a concentration tank for reduced pressure concentration to obtain an extract; S10, placing the extract in step S9 into a vacuum drying device for vacuum drying to obtain a dry extract; Step 2: Preparation of granules: A1. Grind the dry extract in step S10 and pass it through a 5-mesh sieve; A2, take 5-10 parts of sodium carboxymethyl starch, 10-20 parts of dextrin and lactose, grind them separately and pass them through a 60-mesh sieve, then mix them with 10-20 parts of stevioside, stir and mix, and pass them through a 60-mesh sieve to obtain a mixed auxiliary material; A3, putting the dry paste powder in step A1 and the mixed auxiliary materials in step A2 into a mixing device and mixing them evenly to obtain a mixture; A4, adding 70% ethanol to the mixed material in step A3 at a ratio of 1:8 to obtain a finished material; A5. The finished product in step A4 is sieved through a 12-mesh sieve for granulation. The wet granules are placed in a drying oven, ventilated and dried, and then sieved through a 12-mesh sieve for granulation. A6. Continue drying the particles in step A5 at 55° C. for 6 hours to obtain finished particles.

4. The manufacturing process of the therapeutic agent for indigestion according to claim 3, characterized in that: The heating reflux time in step S2 is 3-5 hours, and the temperature is 50-60°C.

5. The manufacturing process of the therapeutic agent for indigestion according to claim 3, characterized in that: The heating reflux time in step S4 is 2-4 hours, and the temperature is 55-65°C.

6. The manufacturing process of the therapeutic agent for indigestion according to claim 3, characterized in that: The reduced pressure concentration temperature in step S6 is maintained at 70-80° C., and the reduced pressure concentration is performed until the relative density reaches 1.12 to 1.

14.

7. The manufacturing process of the therapeutic agent for indigestion according to claim 3, characterized in that: The refrigeration temperature in step S7 is 2° C., and the refrigeration time is 18 hours.

8. The manufacturing process of the therapeutic agent for indigestion according to claim 3, characterized in that: In step S9, the reduced pressure concentration temperature is maintained at 40-50° C., and the reduced pressure concentration is performed to a density of 1.24-1.

26.

9. The manufacturing process of the therapeutic agent for indigestion according to claim 3, characterized in that: The vacuum drying temperature in step 10 is 40-50° C., and the vacuum drying time is 18 hours.

10. The manufacturing process of the therapeutic agent for indigestion according to claim 3, characterized in that: In step A5, the drying temperature is 55° C. and the ventilation drying time is 40 minutes.