Pressure control system of organ perfusion equipment

Abstract

The invention provides a pressure control system of organ perfusion equipment, which adopts a vein loop and an artery loop, and is additionally provided with a pressure monitoring sensor on each loop. The sensor transmits the arterial pressure value and the venous pressure value to the regulation and control module, so that the regulation and control module regulates and controls the rotating speed of the centrifugal pumps in the two loops through a PID control algorithm, the regulated venous pressure value and the regulated arterial pressure value reach preset values, and automatic pressure feedback and regulation are achieved in the organ perfusion process. Meanwhile, the preset arterial pressure value is a periodically changing numerical value, the pulsation effect of human blood can be simulated in the arteries, and the constant flow effect is adopted in the veins.

Description

Technical Field

[0001] The invention belongs to the medical field, and in particular relates to a pressure control system of an organ perfusion device. Background Art

[0002] Organ perfusion technology is an important clinical method in the process of organ preservation and repair, and is widely used in the maintenance of organ function in vitro, especially in transplantation of high-demand organs such as the liver, heart, and kidney. Although traditional cryopreservation methods can effectively slow down organ metabolism and reduce cell damage, due to the lack of blood perfusion and oxygen supply, there is still a risk of organ damage caused by ischemia and hypoxia, which affects the functional survival rate of the organ and the transplant effect. Therefore, normothermic in vitro organ perfusion technology has gradually become an important research direction.

[0003] During organ perfusion, perfusion pressure is one of the key parameters that determine organ function recovery and protection. Appropriate perfusion pressure can maintain the blood perfusion state of the organ, promote the removal of metabolic waste and functional recovery in the organ, while excessive perfusion pressure may cause organ vascular damage and affect the transplantation effect. Therefore, real-time monitoring and precise control of pressure during perfusion is of great clinical significance.

[0004] Most existing organ perfusion devices only have the function of monitoring pressure, requiring operators to manually adjust the perfusion pressure according to the monitored pressure value. This manual adjustment method not only relies heavily on the operator's experience, but also fails to make quick adjustments when the pressure changes, resulting in unstable perfusion pressure and insufficient control accuracy, which is difficult to meet clinical needs. Summary of the invention

[0005] The present invention provides a pressure control system for an organ perfusion device, so as to solve the problems that the existing organ perfusion device needs to manually adjust the pressure value, is prone to unstable perfusion pressure, and has insufficient control accuracy. In order to solve the above technical problems, the embodiments of the present invention disclose the following technical solutions: One aspect of the present invention provides a pressure control system for an organ perfusion device, which is applied to an organ perfusion device having a venous centrifugal pump and an arterial centrifugal pump, and the system comprises: A venous pressure sensor disposed at the outlet of the venous centrifugal pump is configured to collect the pressure value of the venous blood pumped out by the venous centrifugal pump; An arterial pressure sensor disposed at the outlet of the arterial centrifugal pump is configured to collect the pressure value of the arterial blood pumped out by the arterial centrifugal pump; A control module is respectively connected to the venous pressure sensor and the arterial pressure sensor in communication, and is configured to monitor the venous pressure value and the arterial pressure value in real time; The control module is further configured to control the rotation speed of the venous centrifugal pump using a PID control algorithm according to a preset venous pressure value, so that the adjusted real-time venous pressure value is equal to the preset venous pressure value, and the venous pressure value is a constant value; And, according to the preset arterial pressure value, the rotation speed of the arterial centrifugal pump is regulated by using a PID control algorithm so that the adjusted real-time arterial pressure value is equal to the preset arterial pressure value, and the preset arterial pressure value is a periodically changing value.

[0006] Optionally, the control module includes a control circuit and a signal acquisition board arranged in the control circuit, wherein: The signal acquisition board is in communication connection with the venous pressure sensor and the arterial pressure sensor, and is configured to receive the real-time venous pressure value and the real-time arterial pressure value transmitted by the venous pressure sensor and the arterial pressure sensor; The control circuit is configured to compare the real-time venous pressure value with the preset venous pressure value, and when the two are not equal, use a PID control algorithm to calculate the current target speed of the venous centrifugal pump; And, comparing the real-time arterial pressure value with the preset arterial pressure value, and using a PID control algorithm to calculate the current target speed of the arterial centrifugal pump when the two are not equal.

[0007] Optionally, the control module further includes a venous encoder motor for driving a venous centrifugal pump and an arterial encoder motor for driving an arterial centrifugal pump, and a motor driver respectively connected to the venous encoder motor, the arterial encoder motor and the control circuit for communication, wherein: The motor driver is configured to generate a venous speed command according to a current target speed of the venous centrifugal pump and send it to the venous encoder motor; and to generate an arterial speed command according to a current target speed of the arterial centrifugal pump and send it to the arterial encoder motor; The venous encoder motor is configured to control the rotation of the venous centrifugal pump according to the received venous speed command, and collect the real-time speed and position state of the venous centrifugal pump and feed it back to the motor driver; The arterial encoder motor is configured to control the rotation of the arterial centrifugal pump according to the received arterial speed command, and collect the real-time speed and position state of the arterial centrifugal pump and feed it back to the motor driver.

[0008] Optionally, the regulation module also includes an input module communicatively connected to the control circuit, configured to receive a pressure adjustment instruction input by a user and send it to the control circuit, wherein the pressure adjustment instruction includes an arterial diastolic pressure value, a systolic pressure value, and a venous constant pressure.

[0009] Optionally, the control circuit is also configured to set the venous constant pressure in the pressure adjustment instruction to a preset venous pressure value, and to calculate the pressure values ​​at multiple moments in the arterial waveform of a single heartbeat based on the arterial diastolic pressure value and systolic pressure value in the pressure adjustment instruction, and set the pressure values ​​at the multiple moments as the preset arterial pressure value of a single heartbeat.

[0010] Optionally, the system also includes a lithium battery pack and a BMS battery management unit, the lithium battery pack is used to supply power to the control module, and the BMS battery management unit is communicatively connected to the lithium battery pack and the signal acquisition board respectively, for monitoring, protecting and managing the working status of the lithium battery pack, and sending the working status of the lithium battery pack to the signal acquisition board.

[0011] Optionally, the system further includes: A venous flow sensor which is communicatively connected to the signal acquisition board and arranged at the output port of the venous centrifugal pump is configured to collect the flow value of the venous blood pumped out by the venous centrifugal pump and send it to the signal acquisition board; The arterial flow sensor, which is communicatively connected to the signal acquisition board and disposed at the output port of the arterial centrifugal pump, is configured to collect the flow value of the arterial blood pumped out by the arterial centrifugal pump and send it to the signal acquisition board.

[0012] Optionally, the organ perfusion equipment further includes an organ preservation chamber and a blood storage tank; The system further comprises a bile detection sensor disposed in the organ preservation chamber and in communication connection with the signal acquisition board, and configured to detect index data of bile discharge from the liver and send the data to the signal acquisition board when the perfused organ is the liver; The system also includes a lactate detection sensor connected to the blood storage tank and in communication with the signal acquisition board, which is used to detect the blood pressure lactate value and send it to the signal acquisition board.

[0013] Optionally, the system further comprises a display screen communicatively connected to the signal acquisition board, and configured to display data collected by the signal acquisition board to a user.

[0014] The pressure control system of an organ perfusion device disclosed in an embodiment of the present invention adopts two circuits, a vein and an artery, and adds a pressure monitoring sensor to each circuit. The sensor transmits the arterial pressure value and the venous pressure value to the control module, so that it uses the PID control algorithm to control the speed of the centrifugal pump in the two circuits, so that the adjusted venous and arterial pressure values ​​reach the preset values, and realizes automatic pressure feedback and regulation during the organ perfusion process. At the same time, the preset arterial pressure value is a periodically changing value, which can simulate the pulsation effect of human blood in the artery, and the constant flow effect is adopted in the vein.

[0015] This Summary is provided to introduce a selection of concepts in a simplified form that are further described below in the Detailed Description. This Summary is not intended to identify key features or essential features of the disclosure, nor is it intended to limit the scope of the disclosure. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The above and other objects, features and advantages of the present disclosure will become more apparent through a more detailed description of exemplary embodiments of the present disclosure in conjunction with the accompanying drawings, wherein like reference numerals generally represent like components throughout the exemplary embodiments of the present disclosure.

[0017] Figure 1 A schematic diagram of the structure of a pressure control system for an organ perfusion device provided by an embodiment of the present invention; Figure 2 A schematic structural diagram of a pressure control system of another organ perfusion device provided by an embodiment of the present invention; Figure 3 A schematic structural diagram of a pressure control system of another organ perfusion device provided in an embodiment of the present invention. DETAILED DESCRIPTION

[0018] Embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. Although embodiments of the present disclosure are shown in the accompanying drawings, it should be understood that the present disclosure can be implemented in various forms and should not be limited by the embodiments set forth herein. On the contrary, these embodiments are provided to make the present disclosure more thorough and complete, and to fully convey the scope of the present disclosure to those skilled in the art.

[0019] As used herein, the term "including" and its variations mean open inclusion, i.e., "including but not limited to". Unless otherwise stated, the term "or" means "and / or". The term "based on" means "based at least in part on". The terms "an example embodiment" and "an embodiment" mean "at least one example embodiment". The term "another embodiment" means "at least one additional embodiment". The terms "first", "second", etc. may refer to different or the same objects. Other explicit and implicit definitions may also be included below.

[0020] Figure 1 A schematic diagram of a pressure control system for an organ perfusion device provided in an embodiment of the present invention is applied to an organ perfusion device having a venous centrifugal pump and an arterial centrifugal pump, such as Figure 1 As shown, the system includes the following components: The venous pressure sensor 1 arranged at the outlet of the venous centrifugal pump, i.e., the first section of the venous blood entering the organ venous perfusion pathway after being pumped out of the centrifugal pump, can collect the pressure value of the venous blood pumped out by the venous centrifugal pump, directly reflect the blood pressure output by the venous centrifugal pump, and avoid the influence of other variables (such as the resistance of blood flow in the pipeline) on the measured value.

[0021] The system further comprises an arterial pressure sensor 2 arranged at the outlet of the arterial centrifugal pump, which is similar to the venous pressure sensor 1 and is used to collect the pressure value of the arterial blood pumped out by the arterial centrifugal pump.

[0022] The system also includes a control module 3 which is respectively connected to the venous pressure sensor 1 and the arterial pressure sensor 2. The venous pressure sensor 1 and the arterial pressure sensor 2 collect the current pressure value at a high frequency and transmit it to the control module 3, so that it can monitor the venous pressure value and the arterial pressure value in real time.

[0023] The control module 3 can also use the PID control algorithm to control the speed of the venous centrifugal pump according to the preset venous pressure value so that the adjusted real-time venous pressure value is equal to the preset venous pressure value, and use the PID control algorithm to control the speed of the arterial centrifugal pump according to the preset arterial pressure value so that the adjusted real-time arterial pressure value is equal to the preset arterial pressure value.

[0024] Among them, the preset venous pressure value remains constant during the operation of the perfusion device until the user changes the value, and then the new preset value is used to guide the speed of the venous centrifugal pump. The preset arterial pressure value is a periodically changing value, that is, when simulating the arterial pulsation effect, the pressure value in each fluctuation process is changing. The fluctuation process is regarded as a cycle, and multiple pressure values ​​are set in a cycle. When comparing the real-time arterial pressure value with the preset arterial pressure value, it is necessary to compare it with the preset pressure value at the corresponding moment in the cycle.

[0025] In one embodiment disclosed in the present invention, Figure 2 As shown, the control module 3 includes a control circuit 301 and a signal acquisition board 302 arranged in the control circuit 301, wherein: The signal acquisition board 302 is communicatively connected with the venous pressure sensor 1 and the arterial pressure sensor 2 , and is capable of receiving the real-time venous pressure value and the real-time arterial pressure value transmitted by the venous pressure sensor 1 and the arterial pressure sensor 2 .

[0026] The signal acquisition board 302 can process signals from multiple sensors simultaneously, and can ensure timely feedback of pressure values ​​of two independent perfusion pathways, venous and arterial.

[0027] The control circuit 301 is used to compare the real-time venous pressure value and the preset venous pressure value, and when the two are not equal, use the PID control algorithm to calculate the current target speed of the venous centrifugal pump; and compare the real-time arterial pressure value and the preset arterial pressure value, and when the two are not equal, use the PID control algorithm to calculate the current target speed of the arterial centrifugal pump.

[0028] The control circuit 301 receives the real-time venous pressure value and compares it with the preset venous pressure value. If the two are found to be unequal, the PID control algorithm is immediately started to calculate the target speed that the venous centrifugal pump currently needs to adjust until the venous pressure reaches the set value.

[0029] Similar to venous regulation, the control circuit 301 receives and compares the real-time arterial pressure value and the preset arterial pressure value. If a deviation is found, the target speed that the arterial centrifugal pump needs to adjust is calculated by the PID control algorithm. Arterial regulation needs to take into account the pulsation simulation of blood, so the speed adjustment of the arterial centrifugal pump presents periodic fluctuations to approach the natural state of the human body.

[0030] The PID algorithm combines proportional (P), integral (I) and differential (D) regulation methods to convert the deviation between the current pressure value and the preset pressure value into a control signal, which is used to calculate the target speed currently required by the centrifugal pump. Among them, proportional regulation can quickly adjust the speed according to the size of the real-time deviation; integral regulation can accumulate pressure deviations to eliminate long-term errors and ensure the accuracy of the target value; differential regulation can predict the adjustment direction according to the pressure change trend to avoid over-adjustment or oscillation.

[0031] The PID algorithm is capable of high-frequency iterative calculations, ensuring that the control system responds quickly to pressure changes and maintains the stability of the target pressure value.

[0032] In one embodiment disclosed in the present invention, Figure 2 As shown, the control module 3 also includes a venous encoder motor 303 for driving a venous centrifugal pump and an arterial encoder motor 304 for driving an arterial centrifugal pump, and a motor driver 305 respectively connected to the venous encoder motor 303, the arterial encoder motor 304 and the control circuit 301 for communication.

[0033] The motor driver 305 can generate a venous speed command according to the current target speed of the venous centrifugal pump and send it to the venous encoder motor 303. The venous encoder motor 303 controls the rotation of the venous centrifugal pump according to the received venous speed command, and collects the real-time speed and position state of the venous centrifugal pump and feeds it back to the motor driver 305.

[0034] The motor driver 305 can also generate an arterial speed command according to the current target speed of the arterial centrifugal pump and send it to the arterial encoder motor 304. The arterial encoder motor 304 can control the rotation of the arterial centrifugal pump according to the received arterial speed command, and collect the real-time speed and position state of the arterial centrifugal pump and feed it back to the motor driver 305.

[0035] The venous encoder motor 303 and the arterial encoder motor 304 are connected to the control circuit 301 through the motor driver 305 to form a complete signal transmission and feedback path, ensuring that the device can accurately control the speed of the pump, thereby achieving precise pressure control.

[0036] In addition, the encoder motor not only provides driving function, but also has the ability to measure position and speed. Through the encoder signal, the motor driver 305 can understand the actual operating status of the centrifugal pump in real time to ensure the accuracy and response speed of regulation.

[0037] In one embodiment disclosed in the present invention, Figure 2 As shown, the regulation module 3 also includes an input module 306 that is communicatively connected to the control circuit 301 and is configured to receive pressure adjustment instructions input by the user and send them to the control circuit 301 . The pressure adjustment instructions include arterial diastolic pressure value, systolic pressure value, and venous constant pressure.

[0038] The core function of the input module 306 is to receive the pressure adjustment instruction input by the user and accurately transmit it to the control circuit 301 to achieve real-time regulation of arterial and venous pressure. The content of the pressure adjustment instruction mainly includes three parameters: arterial diastolic pressure value, arterial systolic pressure value, and venous constant pressure value. These parameters can be set through the input module 306, reflecting the pressure requirements and control targets of different vascular circuits.

[0039] The user inputs the arterial diastolic pressure value, arterial systolic pressure value, and venous constant pressure value through the input module 306, such as a touch screen, a knob, a button, or other interactive devices. After receiving the instructions, the input module 306 digitally processes them and transmits them to the control circuit 301. The control circuit 301 dynamically adjusts the corresponding centrifugal pump speed through the PID control algorithm according to these set values ​​to achieve accurate maintenance of the target pressure.

[0040] In one embodiment disclosed in the present invention, Figure 2 As shown, the control circuit 301 is also configured to set the venous constant pressure in the pressure adjustment instruction to a preset venous pressure value, and to calculate the pressure values ​​at multiple moments in the arterial waveform of a single heartbeat based on the arterial diastolic pressure value and systolic pressure value in the pressure adjustment instruction, and set the pressure values ​​at these multiple moments to the preset arterial pressure value of a single heartbeat.

[0041] For the venous blood vessels, the pressure characteristic is constant, and the venous constant pressure value input by the user is used as the preset venous pressure value. The control circuit 301 compares the real-time collected venous pressure value with the preset value, and calculates the current target speed of the venous centrifugal pump through the PID algorithm. The speed of the venous centrifugal pump is adjusted with the real-time pressure change, so as to maintain a stable venous pressure output.

[0042] For arterial blood vessels, the input diastolic pressure value and systolic pressure value will be used to generate a periodic arterial pressure waveform to simulate the pressure change of human blood during heart beats. After receiving the arterial diastolic pressure value and arterial systolic pressure value, the control circuit 301 converts the two pressure values ​​into a single heartbeat arterial waveform using the standard arterial pressure value waveform of a single heartbeat.

[0043] For example, a standard arterial pressure value waveform is preset, and its diastolic pressure value A1 and systolic pressure value B1 are compared with the diastolic pressure value A2 and systolic pressure value B2 input by the user, and the pressure values ​​of other data points in the waveform are modified accordingly (for example, the diastolic pressure value in the curve takes the diastolic pressure value A2 input by the user, the systolic pressure value in the curve takes the systolic pressure value B2 input by the user, and the pressure values ​​of other data points are the sum of the original value and [(A1-A2)+(B1-B2)] / 2), and the newly obtained waveform is used as the arterial waveform of a single heartbeat.

[0044] The deviation between the real-time monitored arterial pressure value and the corresponding time point of the arterial waveform of a single heartbeat is periodically compared (i.e., the arterial waveform of a single heartbeat is taken as a cycle, and the real-time arterial pressure value and the arterial waveform are compared according to the cycle). By adjusting the speed of the arterial centrifugal pump, accurate tracking and dynamic regulation of arterial pressure can be achieved.

[0045] In one embodiment disclosed in the present invention, Figure 2 As shown, the system also includes a lithium battery pack 4 and a BMS battery management unit 5. The lithium battery pack 4 is used to supply power to the control module 3. The BMS battery management unit 5 is respectively communicated with the lithium battery pack 4 and the signal acquisition board 302 for monitoring, protecting and managing the working status of the lithium battery pack 4, and sending the working status of the lithium battery pack 4 to the signal acquisition board 302.

[0046] As the power source of the system, the lithium battery pack 4 is responsible for supplying power to various components in the control module 3. The lithium battery pack 4 has high energy density, long service life and good charging and discharging characteristics, which enables the device to maintain stable power supply during long-term operation. In addition, the portability of the lithium battery pack 4 also enhances the flexibility of the device, enabling it to be widely used in clinical operating rooms, laboratories, and even field rescue scenarios.

[0047] The BMS battery management unit 5 is connected to the lithium battery pack 4 in communication and assumes the core functions of monitoring, protecting and managing the battery pack. The BMS ensures that the battery pack is always in a safe and stable working state by monitoring the key parameters of the battery pack in real time, such as voltage, current, temperature and remaining power. For example, when the voltage of the battery pack is too high or too low, the temperature is too high, or there is an overload current, the BMS will promptly issue a warning signal and take corresponding protective measures, such as cutting off power supply or reducing power consumption, to prevent damage to the battery pack or safety accidents.

[0048] At the same time, the BMS battery management unit 5 is also connected to the signal acquisition board 302 for communication, and transmits the real-time working status of the battery pack to the signal acquisition board 302 through a dedicated data interface or wireless communication. The signal acquisition board 302 transmits the working status of the battery pack to the device interface to display the battery status information in real time, such as the remaining power and operating time, and can also issue an early warning to the user when the battery power is low, thereby ensuring the continuous operation of the device.

[0049] In addition, the BMS can also control the balanced charging of the lithium battery pack 4. By monitoring the voltage of each battery cell, the BMS can dynamically adjust the charging rate of the single battery during the charging process to ensure that all battery cells in the battery pack remain in a balanced state.

[0050] In one embodiment disclosed in the present invention, Figure 2 As shown, the system also includes a venous flow sensor 6 which is communicatively connected to the signal acquisition board 302 and disposed at the output port of the venous centrifugal pump, and is configured to collect the flow value of the venous blood pumped out by the venous centrifugal pump and send it to the signal acquisition board 302; and an arterial flow sensor 7 which is communicatively connected to the signal acquisition board 302 and disposed at the output port of the arterial centrifugal pump, and is configured to collect the flow value of the arterial blood pumped out by the arterial centrifugal pump and send it to the signal acquisition board 302.

[0051] The venous flow sensor 6 and the arterial flow sensor 7 monitor the flow of venous and arterial blood independently. The purpose of monitoring venous flow is to ensure that the portal vein of the perfused organ can maintain a constant blood flow, to prevent organ ischemia due to insufficient flow, and to avoid tissue damage caused by excessive flow. The purpose of monitoring arterial flow is to simulate the pulsation characteristics of human arteries, and to ensure that the arterial blood supply of the perfused organ is sufficient but not excessive. The combination of the two makes the entire perfusion process closer to the natural physiological state of the human body, and optimizes the preservation and repair effect of the organ.

[0052] In one embodiment disclosed in the present invention, Figure 2 As shown, the organ perfusion equipment also includes an organ preservation chamber and a blood storage tank; The system further includes a bile detection sensor 8 disposed in the organ storage bin and in communication connection with the signal acquisition board 302, configured to detect index data (such as weight) of bile discharged by the liver and send it to the signal acquisition board 302 when the perfused organ is the liver; The system also includes a lactate detection sensor 9 which is connected to the blood storage tank and is in communication with the signal acquisition board 302 , and is used to detect the blood pressure lactate value and send it to the signal acquisition board 302 .

[0053] The organ storage chamber provides a stable environment for the perfused organs. Its design is suitable for the fixation and protection of the organs and supports the regulation of pressure, flow and other physiological parameters during the perfusion process. The blood storage tank is used to store and circulate the blood required for perfusion, ensuring the stability of the blood supply and facilitating the monitoring and regulation of the biochemical state of the blood.

[0054] In the organ storage chamber, a bile detection sensor 8 is configured to communicate with the signal acquisition board 302. When the perfused organ is the liver, the bile detection sensor 8 can monitor the bile discharged from the liver in real time and transmit the bile-related index data to the signal acquisition board 302. Bile secretion is an important physiological indicator for evaluating liver function. By detecting the secretion volume, composition and change trend of bile, it can be intuitively judged whether the liver is in a healthy state, whether it is suitable for transplantation or needs further repair. In addition, the detection data can also help optimize the perfusion process. For example, when bile secretion is reduced or stopped, the arteriovenous perfusion pressure or flow can be adjusted in time to stimulate the recovery of liver function.

[0055] A lactic acid detection sensor 9 is arranged at the pipeline connected to the blood storage tank, which is in communication connection with the signal acquisition board 302 for real-time detection of the concentration of lactic acid in the blood. Lactic acid is an important metabolite in the blood, and changes in its concentration reflect the metabolic state of the perfused organ and the quality of blood circulation. If the lactic acid concentration increases, it may mean that the perfused organ is in a state of hypoxia or metabolic disorder. Through the data provided by the lactic acid detection sensor 9, the signal acquisition board 302 can adjust the perfusion parameters in time, such as increasing the blood flow rate or improving the oxygen supply efficiency, thereby reducing the lactic acid level and improving the metabolic environment of the organ.

[0056] The output data of the bile detection sensor 8 and the lactate detection sensor 9 are transmitted to the upper monitoring system through the signal acquisition board 301, which is not only used to control the perfusion parameters in real time, but also can be used as an objective evaluation index of organ function and perfusion effect, providing a basis for decision-making for medical staff. For example, if the bile secretion continues to increase and the lactate concentration decreases, it can be judged that the perfused organ function has recovered well and is suitable for transplantation; on the contrary, if the bile secretion decreases and the lactate concentration increases, it indicates that there may be a problem, and the perfusion strategy needs to be adjusted or the organ status needs to be re-evaluated.

[0057] In one embodiment disclosed in the present invention, Figure 2 As shown, the system also includes a display screen 10 that is in communication with the signal acquisition board 302 and is configured to display the data collected by the signal acquisition board 302 to the user, so as to realize an intuitive display of the data collected by the system. As one of the human-computer interaction interfaces of the device, the display screen 10 can display the data collected and processed by the signal acquisition board 302 to the user in real time in the form of numbers, charts or dynamic waveforms, so that the user can have a comprehensive understanding of the key parameters of the perfusion process.

[0058] The display screen 10 is configured to display various types of data, including but not limited to venous pressure, arterial pressure, venous flow, arterial flow, bile secretion, lactate concentration, and the working status of the lithium battery pack 4. These data are classified and arranged on the interface of the display screen 10, and the user can obtain important information at a glance. For example, the pressure curve and flow waveform on the display screen 10 can help the user evaluate whether the current perfusion state meets expectations, and the bile secretion and lactate concentration data provide an intuitive reference for the recovery of organ function.

[0059] In addition, the display screen 10 can also display the system's operating prompts and alarm information. When abnormal data is detected, such as excessive pressure, insufficient flow, or increased lactate concentration, the system will issue a warning through the display screen 10 to prompt the user to take timely measures. Through the intuitive feedback of the display screen 10, the user can quickly locate the problem and make adjustments, thereby avoiding organ damage caused by abnormal parameters.

[0060] The display screen 10 also supports interactive operations between the user and the system. The user can view historical data records through the display screen 10 to understand the trend of parameter changes during the perfusion process and judge the perfusion effect through comparative analysis. In addition, the display screen 10 can also be used to display the target parameters input by the user, such as arterial diastolic pressure, systolic pressure, and venous constant pressure, so that the user can confirm whether the set value is correct.

[0061] Figure 3 The specific structure of a pressure control system of an organ perfusion device disclosed in the present invention is shown, which can be used as a supplement and reference to the above embodiments.

[0062] The embodiments of the present disclosure have been described above, and the above description is exemplary, not exhaustive, and is not limited to the disclosed embodiments. Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments. The selection of terms used herein is intended to best explain the principles of the embodiments, practical applications, or technical improvements to the technology in the market, or to enable other persons of ordinary skill in the art to understand the embodiments disclosed herein.

Claims

1. A pressure control system for an organ perfusion device, applied to an organ perfusion device having a venous centrifugal pump and an arterial centrifugal pump, characterized in that: The system comprises: A venous pressure sensor disposed at the outlet of the venous centrifugal pump is configured to collect the pressure value of the venous blood pumped out by the venous centrifugal pump; An arterial pressure sensor disposed at the output port of the arterial centrifugal pump is configured to collect the pressure value of the arterial blood pumped out by the arterial centrifugal pump; A control module is respectively connected to the venous pressure sensor and the arterial pressure sensor in communication, and is configured to monitor the venous pressure value and the arterial pressure value in real time; The control module is further configured to control the rotation speed of the venous centrifugal pump using a PID control algorithm according to a preset venous pressure value, so that the adjusted real-time venous pressure value is equal to the preset venous pressure value, and the venous pressure value is a constant value; And, according to the preset arterial pressure value, the rotation speed of the arterial centrifugal pump is regulated by using a PID control algorithm so that the adjusted real-time arterial pressure value is equal to the preset arterial pressure value, and the preset arterial pressure value is a periodically changing value.

2. The pressure control system according to claim 1, characterized in that: The control module includes a control circuit and a signal acquisition board arranged in the control circuit, wherein: The signal acquisition board is in communication connection with the venous pressure sensor and the arterial pressure sensor, and is configured to receive the real-time venous pressure value and the real-time arterial pressure value transmitted by the venous pressure sensor and the arterial pressure sensor; The control circuit is configured to compare the real-time venous pressure value with the preset venous pressure value, and when the two are not equal, use a PID control algorithm to calculate the current target speed of the venous centrifugal pump; And, comparing the real-time arterial pressure value with the preset arterial pressure value, and using a PID control algorithm to calculate the current target speed of the arterial centrifugal pump when the two are not equal.

3. The pressure control system according to claim 2, characterized in that: The control module also includes a venous encoder motor for driving a venous centrifugal pump and an arterial encoder motor for driving an arterial centrifugal pump, and a motor driver respectively connected to the venous encoder motor, the arterial encoder motor and the control circuit for communication, wherein: The motor driver is configured to generate a venous speed command according to a current target speed of the venous centrifugal pump and send it to the venous encoder motor; and to generate an arterial speed command according to a current target speed of the arterial centrifugal pump and send it to the arterial encoder motor; The venous encoder motor is configured to control the rotation of the venous centrifugal pump according to the received venous speed command, and collect the real-time speed and position state of the venous centrifugal pump and feed it back to the motor driver; The arterial encoder motor is configured to control the rotation of the arterial centrifugal pump according to the received arterial speed command, and collect the real-time speed and position state of the arterial centrifugal pump and feed it back to the motor driver.

4. The pressure control system according to claim 2, characterized in that: The control module also includes an input module that is communicatively connected to the control circuit and is configured to receive a pressure adjustment instruction input by a user and send it to the control circuit. The pressure adjustment instruction includes an arterial diastolic pressure value, a systolic pressure value, and a venous constant pressure.

5. The pressure control system according to claim 4, characterized in that: The control circuit is also configured to set the venous constant pressure in the pressure adjustment instruction to a preset venous pressure value, and to calculate the pressure values ​​at multiple moments in the arterial waveform of a single heartbeat based on the arterial diastolic pressure value and systolic pressure value in the pressure adjustment instruction, and to set the pressure values ​​at the multiple moments to the preset arterial pressure value of a single heartbeat.

6. The pressure control system according to claim 2, characterized in that: The system also includes a lithium battery pack and a BMS battery management unit. The lithium battery pack is used to supply power to the control module. The BMS battery management unit is respectively communicated with the lithium battery pack and the signal acquisition board to monitor, protect and manage the working status of the lithium battery pack, and send the working status of the lithium battery pack to the signal acquisition board.

7. The pressure control system according to claim 2, characterized in that: The system further comprises: A venous flow sensor which is communicatively connected to the signal acquisition board and arranged at the output port of the venous centrifugal pump is configured to collect the flow value of the venous blood pumped out by the venous centrifugal pump and send it to the signal acquisition board; The arterial flow sensor, which is communicatively connected to the signal acquisition board and disposed at the output port of the arterial centrifugal pump, is configured to collect the flow value of the arterial blood pumped out by the arterial centrifugal pump and send it to the signal acquisition board.

8. The pressure control system according to claim 2, characterized in that: The organ perfusion equipment also includes an organ storage chamber and a blood storage tank; The system further comprises a bile detection sensor disposed in the organ preservation chamber and in communication connection with the signal acquisition board, and configured to detect index data of bile discharge from the liver and send the data to the signal acquisition board when the perfused organ is the liver; The system also includes a lactate detection sensor connected to the blood storage tank and in communication with the signal acquisition board, which is used to detect the blood pressure lactate value and send it to the signal acquisition board.

9. The pressure control system according to any one of claims 1 to 8, characterized in that: The system also includes a display screen that is communicatively connected to the signal acquisition board and is configured to display data collected by the signal acquisition board to a user.

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