Stent of interventional replacement valve and interventional replacement valve

Abstract

The invention provides a stent of an interventional replacement valve and the interventional replacement valve. The stent for interventional replacement of the valve comprises a first grid stent part which comprises a first main body formed by cutting a pipe, and the first main body comprises a first free end and a first connecting end which are oppositely arranged in the length direction of the stent; the second grid support part is arranged at the first connecting end of the first main body in the length direction of the support, the second grid support part comprises a second main body formed by weaving wires, the second main body comprises a second connecting end and a second free end which are oppositely arranged in the length direction, and the second connecting end is connected to the first connecting end. The interventional replacement valve comprises the stent of the interventional replacement valve.

Description

Technical Field

[0001] The present application relates to the field of medical devices, and in particular to a stent for an interventional valve replacement and an interventional valve replacement. Background Art

[0002] Transcatheter pulmonary valve replacement (TPVR), also known as percutaneous pulmonary valve implantation (PPVI), is a minimally invasive technique that uses X-ray and / or ultrasound images as a guide to insert an artificial pulmonary valve into the diseased pulmonary valve through transcatheter intervention while the heart is beating, thereby functionally completing the pulmonary valve replacement.

[0003] The interventional replacement valves used for TPVR can be divided into balloon-expandable valves and self-expandable valves according to their principles. The balloon-expandable valve adopts a straight-cylinder design and relies on radial support force to fix it, which is more suitable for patients with valved vascular channels. The self-expandable valve adopts a double dumbbell design to prevent the stent from shifting up and down, and is more suitable for patients with native outflow tracts.

[0004] In the related art, some stents for interventional valve replacement are made of woven metal wires or cut from metal tubes.

[0005] The radial support force of the stent woven with metal wire is relatively low. After being implanted in the human pulmonary artery, it is prone to displacement and paravalvular leakage. Improving the radial support force can only be achieved by increasing the metal surface area, which may increase the compression size of the valve and require a larger delivery system; it will also increase the risk of thrombosis - thrombi may form on the surface of the stent and cause blood flow obstruction, which may be a potential complication, and may also lead to increased tissue irritation - increasing the metal surface area may increase the contact area between the stent and the blood vessel wall, which may lead to more tissue irritation reactions, which may cause inflammation or allergic reactions in some patients.

[0006] The metal-cut stent is made of the same material and process, and the overall rigidity of the stent is relatively large. The large overall rigidity of the stent will lead to the unreasonable allocation of the performance of the interventional replacement valve at the proximal and distal ends of the pulmonary artery. At the same time, different connection structures and connection methods also affect the fatigue life of the stent.

[0007] The above statements are only used to provide background information related to the present application and do not necessarily constitute prior art. Summary of the invention

[0008] The purpose of the present application is to provide a stent and an interventional replacement valve for an interventional replacement valve, aiming to reasonably adjust the performance of the stent and the interventional replacement valve at the proximal and distal ends of the pulmonary artery.

[0009] The first aspect of the present application provides a stent for interventional valve replacement, comprising:

[0010] The first grid support part comprises a first main body made by cutting a tube, wherein the first main body comprises a first free end and a first connecting end which are arranged opposite to each other along the length direction of the support;

[0011] The second grid bracket portion is arranged at the first connection end of the first main body along the length direction of the bracket, and the second grid bracket portion includes a second main body made of woven wire, and the second main body includes a second connection end and a second free end arranged opposite to each other along the length direction, and the second connection end is connected to the first connection end.

[0012] In some embodiments of the stent for interventional valve replacement,

[0013] The first connecting end includes a plurality of first turning portions facing the second grid support portion;

[0014] The second connecting end includes a plurality of second turning portions facing the first grid support portion;

[0015] At least part of the first turning portion and at least part of the second turning portion are respectively opposite to each other and movably connected.

[0016] In some embodiments of the stent for interventional valve replacement, among the first turning portion and the second turning portion which are relatively and movably connected, a side of at least one of the first turning portions facing the corresponding second turning portion abuts against a side of the corresponding second turning portion facing the first turning portion.

[0017] In some embodiments of the stent for interventional valve replacement, among the first turning portion and the second turning portion which are relatively and movably connected, a side of at least one of the first turning portions facing the corresponding second turning portion includes a recessed portion which is recessed toward a side away from the second turning portion, and the corresponding second turning portion is located in the recessed portion.

[0018] In some embodiments of the stent for interventional valve replacement,

[0019] Among the first turning parts and the second turning parts which are relatively and movably connected, at least one of the first turning parts is provided with a wire installation hole or a wire installation groove, and the wire forming the corresponding second turning part is installed in the wire installation hole or the wire installation groove; and / or

[0020] Among the first turning part and the second turning part which are relatively and movably connected, at least one of the first turning parts is provided with a protrusion mounting hole or a protrusion mounting groove on the side facing the corresponding second turning part, and the corresponding second turning part has a protrusion connected to the wire forming the second turning part, and the protrusion is installed in the protrusion mounting hole or the protrusion mounting groove.

[0021] In some embodiments of the stent for interventional valve replacement,

[0022] The first grid support part comprises a support rod forming the first main body and a connecting part provided on the support rod, and the wire installation hole or the wire installation groove is provided on the connecting part; and / or

[0023] The wire installation hole or the wire installation groove extends along the circumference of the bracket; and / or

[0024] The dimension of the wire installation hole perpendicular to the extension direction thereof or the width of the wire installation slot is greater than the dimension of the wire forming the second turning portion in the corresponding direction, so that the wire forming the second turning portion has a movable margin in the wire installation hole or the wire installation slot; and / or

[0025] The first grid support part comprises a support rod forming the first main body and a connecting part provided on the support rod, and the protrusion mounting hole or the protrusion mounting groove is provided on the connecting part; and / or

[0026] The boss mounting hole or the boss mounting groove extends along the length direction of the bracket; and / or

[0027] The dimension of the boss mounting hole perpendicular to the extension direction thereof or the width of the boss mounting groove is greater than the dimension of the boss in the corresponding direction, so that the boss has a movable margin in the boss mounting hole or the boss mounting groove; and / or

[0028] The dimension of the protrusion mounting hole along the extending direction thereof or the dimension of the protrusion mounting groove along the extending direction thereof is greater than the dimension of the protrusion in the corresponding direction.

[0029] In some embodiments of the stent for interventional valve replacement,

[0030] An opening of at least one of the wire installation slots is formed radially inward of the first grid support portion; and / or

[0031] An opening of at least one of the wire installation grooves is formed on a side of the first grid support portion facing the second grid support portion; and / or

[0032] At least one of the protrusions extends from the wire of the second turning portion toward the first turning portion, and an opening of the protrusion mounting groove is formed on the radial inner side of the first grid support portion and on a side facing the second grid support portion.

[0033] In some embodiments of the stent for interventional valve replacement, the first mesh stent portion is directly connected to the second mesh stent portion and / or connected via sutures.

[0034] In some embodiments of the stent for interventional valve replacement, the first lattice stent portion includes suture holes for passing the suture.

[0035] In some embodiments of the stent for interventional valve replacement,

[0036] The first grid support portion comprises a support rod forming a first body, and the suture perforations are arranged on the support rod; and / or

[0037] The first grid support part includes a support rod forming a first main body and a connecting part arranged on the support rod, and the suture perforation is arranged on the connecting part.

[0038] In some embodiments of the stent for interventional valve replacement, the stent has a first diameter expansion section, a cylindrical section, and a second diameter expansion section along the length direction, the first diameter expansion section gradually increases in diameter from the cylindrical section to an end away from the cylindrical section, the large end of the first diameter expansion section forms the first free end, the first grid stent portion includes the first diameter expansion section and the cylindrical section, the second diameter expansion section gradually increases in diameter from the cylindrical section to an end away from the cylindrical section, the second grid stent portion includes the second diameter expansion section, and the large end of the second diameter expansion section forms the second free end, wherein,

[0039] The portion of the first main body located in the first diameter expansion section and the portion of the first main body located between the cylindrical sections are connected by a plurality of first connecting rods; and / or

[0040] The second main body includes more than one wavy ring arranged along the length direction, wherein the second grid support portion is conical or transitions from conical to cylindrical.

[0041] In some embodiments of the stent for interventional valve replacement, the second grid stent portion includes more than one wavy ring arranged along the length direction, wherein:

[0042] Among the one or more wavy rings, the waveform of at least one of the wavy rings is a waveform of constant amplitude; and / or

[0043] Among the one or more wavy rings, the waveform of at least one of the wavy rings is a variable amplitude waveform.

[0044] In some embodiments of the stent for interventional valve replacement,

[0045] The waveform of the wavy ring farthest from the first grid support portion is a variable amplitude waveform; and / or

[0046] The waveform of the wavy ring closest to the first grid support portion is a variable amplitude waveform.

[0047] In some embodiments of the stent for interventional valve replacement, the second body includes two or more wavy rings arranged along the length direction, wherein

[0048] The wave-shaped turning parts on opposite sides of at least two adjacent wave-shaped rings correspond to each other one by one; and / or

[0049] The wave-shaped turning parts on opposite sides of at least two adjacent wave-shaped rings are arranged in a staggered manner.

[0050] In some embodiments of the stent for interventional valve replacement,

[0051] The first connecting end includes a plurality of first turning portions facing the second grid support portion;

[0052] The second connecting end includes a plurality of second turning portions facing the first grid support portion;

[0053] At least a portion of the first turning portion and at least a portion of the second turning portion are respectively opposite to and fixedly connected.

[0054] In some embodiments of the stent for interventional valve replacement, at least a portion of the first turning portion and at least a portion of the second turning portion are respectively relatively and movably connected, and the top end of the first turning portion and the second turning portion that are relatively and movably connected facing the first grid stent portion is closer to the first grid stent portion than the top end of the first turning portion and the second turning portion that are relatively and fixedly connected facing the first grid stent portion.

[0055] In some embodiments of the stent for interventional valve replacement, the first turning portion and the second turning portion, which are relatively and fixedly connected, are connected by a second connecting rod, and the top end of the second turning portion facing the first grid stent portion of the first turning portion and the second turning portion, which are relatively and movably connected, is closer to the first grid stent portion than the end of the second connecting rod close to the first grid stent portion.

[0056] In some embodiments of the stent for interventional valve replacement, the first turning portion and the second turning portion which are relatively and fixedly connected are connected by a second connecting rod.

[0057] In some embodiments of the stent for interventional valve replacement,

[0058] The first free end is provided with a plurality of connection ears evenly distributed along the circumference of the interventional replacement valve; or

[0059] The second free end is provided with a plurality of second connecting ears evenly distributed along the circumference of the interventional replacement valve.

[0060] A second aspect of the present application provides an interventional replacement valve, comprising a stent, a sealing membrane and a valve leaflet, wherein the stent is the stent of the interventional replacement valve described in the first aspect of the present application.

[0061] In some embodiments of the interventional valve replacement,

[0062] The stent has a first diameter-expanding section, a cylindrical section, and a second diameter-expanding section along the length direction, the first diameter-expanding section gradually increases in diameter from the cylindrical section to an end away from the cylindrical section, the large end of the first diameter-expanding section forms the first free end, the first grid stent portion includes the first diameter-expanding section and the cylindrical section, the second diameter-expanding section gradually increases in diameter from the cylindrical section to an end away from the cylindrical section, the second grid stent portion includes the second diameter-expanding section, and the large end of the second diameter-expanding section forms the second free end; wherein

[0063] The sealing film is fixed to the inner periphery of the stent by sutures; and / or

[0064] The arc of the leaflet is sutured to the cylindrical segment; and / or

[0065] The columnar segment is provided with a fixing groove for installing a developing material, and the interventional replacement valve includes the developing material arranged on the fixing groove.

[0066] In some embodiments of the interventional replacement valve, the interventional replacement valve is a pulmonary valve.

[0067] Based on the stent of the interventional replacement valve provided by the present application, when forming an interventional replacement valve, such as a pulmonary valve, the first grid stent portion can be configured at the proximal end of the interventional replacement valve, and the second grid stent portion can be configured at the distal end of the interventional replacement valve. The shape of the distal end of patients with pulmonary artery lesions is more complex than the proximal end, and more are non-circular surfaces, and the proximal end and the valve ring position require a larger radial support force to ensure that the circular physiological morphology of the pulmonary artery is maintained after the stent is implanted. Since the stent is cut from a tubular material at the proximal end of the interventional replacement valve and the distal end is woven from a wire material, after the stent is implanted, the overall radial support force of the stent on the proximal end is relatively high, which is conducive to maintaining the circular physiological morphology of the proximal end. The stent has good flexibility and compliance at the distal end, which is conducive to making the stent have good wall adhesion performance, thereby reducing the risk of side leakage from both ends of the interventional replacement valve.

[0068] The interventional replacement valve provided in the present application has the same advantages as the stent of the interventional replacement valve provided in the present application.

[0069] Other features and advantages of the present application will become apparent from the following detailed description of exemplary embodiments of the present application with reference to the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0070] The drawings described herein are used to provide a further understanding of the present application and constitute a part of the present application. The illustrative embodiments of the present application and their descriptions are used to explain the present application and do not constitute an improper limitation on the present application. In the drawings:

[0071] Figure 1A and Figure 1B It is a schematic diagram of the structure of interventional valve replacement in different directions according to some embodiments of the present application.

[0072] Figure 2 It is a schematic diagram of the structure of a stent for interventional valve replacement in some embodiments of the present application.

[0073] Figure 3 This is a structural schematic diagram of the stent of the interventional replacement valve in some embodiments of the present application, which shows the closed grid structure of the proximal end portion of the stent and the wavy ring of the distal end portion of the stent, wherein A is the closed grid structure of the proximal end portion of the stent, and B is the wavy ring of the distal end portion of the stent.

[0074] Figure 4 It is a schematic diagram of the partial structure of the wavy ring at the distal end of the stent of the interventional valve replacement stent in some embodiments of the present application.

[0075] Figure 5A and Figure 5B It is a connection structure between a closed grid-type structure at the proximal end portion of the stent and a wavy ring at the distal end portion of the stent in the interventional valve replacement stent of some embodiments of the present application.

[0076] Fig. 6A and Figure 6B It is a connection structure between a closed grid-type structure at the proximal end portion of the stent and a wavy ring at the distal end portion of the stent in the interventional valve replacement stent of some embodiments of the present application.

[0077] FIG. 7A to FIG. 7C It is a connection structure between a closed grid-type structure at the proximal end portion of the stent and a wavy ring at the distal end portion of the stent in the interventional valve replacement stent of some embodiments of the present application.

[0078] FIG. 8A to FIG. 8CIt is a connection structure between a closed grid-type structure at the proximal end portion of the stent and a wavy ring at the distal end portion of the stent in the interventional valve replacement stent of some embodiments of the present application.

[0079] 9A to 9D It is a connection structure between a closed grid-type structure at the proximal end portion of the stent and a wavy ring at the distal end portion of the stent in the interventional valve replacement stent of some embodiments of the present application.

[0080] FIG. 10A to FIG. 10D It is a connection structure between a closed grid-type structure at the proximal end portion of the stent and a wavy ring at the distal end portion of the stent in the interventional valve replacement stent of some embodiments of the present application.

[0081] Fig.11A and Fig. 11B It is a connection structure between a closed grid-type structure at the proximal end portion of the stent and a wavy ring at the distal end portion of the stent in the interventional valve replacement stent of some embodiments of the present application.

[0082] Fig. 12A and Fig. 12B It is a connection structure between a closed grid-type structure at the proximal end portion of the stent and a wavy ring at the distal end portion of the stent in the interventional valve replacement stent of some embodiments of the present application.

[0083] Fig.13 It is a schematic diagram of the partial structure of the wavy ring at the distal end of the stent of the interventional valve replacement stent in some embodiments of the present application.

[0084] FIG. 14A to FIG. 14D It is a connection structure between a closed grid-type structure at the proximal end portion of the stent and a wavy ring at the distal end portion of the stent in the interventional valve replacement stent of some embodiments of the present application.

[0085] FIG. 15A to FIG. 15D It is a connection structure between a closed grid-type structure at the proximal end portion of the stent and a wavy ring at the distal end portion of the stent in the interventional valve replacement stent of some embodiments of the present application.

[0086] Fig.16 It is a schematic diagram of the structure of a stent for interventional valve replacement in some embodiments of the present application.

[0087] Fig.17 It is a schematic diagram of the structure of a stent for interventional valve replacement in some embodiments of the present application.

[0088] Fig.18 It is a schematic diagram of the structure of a stent for interventional valve replacement in some embodiments of the present application.

[0089] Fig.19 It is a schematic diagram of the structure of a stent for interventional valve replacement in some embodiments of the present application.

[0090] Fig. 20 It is a schematic diagram of the structure of the wavy rings of each layer at the distal end portion of the stent of the interventional replacement valve in some embodiments of the present application.

[0091] Fig.21 It is a schematic diagram of the structure of the wavy rings of each layer at the distal end portion of the stent of the interventional replacement valve in some embodiments of the present application.

[0092] Fig. 22 It is a schematic structural diagram of the outer layer of the wavy ring at the distal end portion of the stent of the interventional replacement valve in some embodiments of the present application.

[0093] Fig.23 It is a schematic diagram of the radially expanded structure of the stent of an interventional valve replacement according to some embodiments of the present application.

[0094] Fig.24 It is a schematic diagram of the radially expanded structure of the stent of an interventional valve replacement according to some embodiments of the present application.

[0095] Fig.25 It is a schematic diagram of the structure of a stent for interventional valve replacement in some embodiments of the present application. DETAILED DESCRIPTION

[0096] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all of the embodiments. The following description of at least one exemplary embodiment is actually only illustrative and is by no means intended to limit the present application and its application or use. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0097] Unless otherwise specifically stated, the relative arrangement, numerical expressions and numerical values ​​of the parts and steps set forth in these embodiments do not limit the scope of the application. Meanwhile, it should be understood that, for ease of description, the sizes of the various parts shown in the accompanying drawings are not drawn according to actual proportional relationships. The technology, methods and equipment known to those of ordinary skill in the relevant art may not be discussed in detail, but in appropriate cases, the technology, methods and equipment should be considered as a part of the specification. In all examples shown and discussed here, any specific value should be interpreted as being merely exemplary, rather than as a limitation. Therefore, other examples of exemplary embodiments may have different values. It should be noted that similar reference numerals and letters represent similar items in the following drawings, and therefore, once a certain item is defined in an accompanying drawing, it does not need to be further discussed in subsequent drawings.

[0098] In the description of the present application, it should be understood that the use of terms such as "first" and "second" to limit components is only for the convenience of distinguishing the corresponding components. Unless otherwise stated, the above terms have no special meaning and therefore cannot be understood as limiting the scope of protection of the present application.

[0099] In the description of the present application, it should be understood that the directions or positional relationships indicated by directional words such as "front, back, up, down, left, right", "lateral, vertical, perpendicular, horizontal" and "top, bottom" are usually based on the directions or positional relationships shown in the drawings, and are only for the convenience of describing the present application and simplifying the description. Unless otherwise specified, these directional words do not indicate or imply that the device or element referred to must have a specific direction or be constructed and operated in a specific direction, and therefore cannot be understood as limiting the scope of protection of the present application; the directional words "inside and outside" refer to the inside and outside relative to the contours of each component itself.

[0100] In addition, the technical features involved in the different embodiments of the present application described below can be combined with each other as long as they do not conflict with each other.

[0101] like Figures 1A to 24 As shown, the embodiment of the present application provides a stent 1 for an interventional replacement valve and an interventional replacement valve.

[0102] like Figure 1A and Figure 1B As shown, the interventional replacement valve (such as a pulmonary valve) mainly includes a stent 1 , a sealing membrane 2 and a valve 3 .

[0103] like Figures 1A to 24 As shown, the stent 1 of the interventional valve replacement of the embodiment of the present application includes a first grid stent portion 11 and a second grid stent portion 12. The first grid stent portion 11 includes a first main body made by cutting a tube, and the first main body includes a first free end 11E and a first connecting end 11F arranged oppositely along the length direction of the stent 1. The second grid stent portion 12 is arranged at the first connecting end 11F of the first main body along the length direction of the stent 1, and the second grid stent portion 12 includes a second main body made by a wire, and the second main body includes a second connecting end 12F and a second free end 12E arranged oppositely along the length direction. The second connecting end 12F is connected to the first connecting end 11F.

[0104] The stent 1 of the interventional replacement valve of the embodiment of the present application, when forming an interventional replacement valve, such as forming a pulmonary valve, can configure the first grid stent portion 11 at the proximal end of the interventional replacement valve (in the present application, "proximal end" refers to the end of the stent 1 close to the right ventricle of the heart, and the first grid stent portion 11 is also called the proximal end portion of the stent), and configure the second grid stent portion 12 at the distal end of the interventional replacement valve (in the present application, "distal end" is the end of the stent 1 away from the right ventricle of the heart, and the second grid stent portion 12 is also called the distal end portion of the stent). The shape of the distal end of the pulmonary artery is more complex than the proximal end, and more of it is a non-circular surface, and the proximal end and the valve ring position require a larger radial support force to ensure that the circular physiological morphology of the pulmonary artery is maintained after the stent 1 is implanted. Since the stent 1 uses a first main body cut from a tube at the proximal end of the interventional replacement valve and a second main body woven from wires at the distal end, after the stent 1 is implanted, the stent 1 has a relatively high overall radial support force on the proximal end, which is beneficial to maintaining the circular physiological shape of the proximal end. The stent 1 has good flexibility and compliance at the distal end, which is beneficial to making the stent 1 have good wall adhesion performance, thereby reducing the risk of side leakage from both ends of the interventional replacement valve.

[0105] The stent 1 of the interventional replacement valve adopts a split structural design with two structures, the distal end and the proximal end. The second body of the second grid stent part 12 of the woven structure can withstand greater deformation. The deformation of the stent 1 at the distal end of the pulmonary artery is large, so that the split structure can disperse stress concentration, thereby helping to improve the fatigue life of the interventional replacement valve.

[0106] Since the first grid stent portion 11 and the second grid stent portion 12 are connected, it is helpful to avoid stress concentration and at the same time, when the stent 1 has begun to release the second grid stent portion 12 and the first grid stent portion 11 has not been released or has been partially released during the operation, the interventional replacement valve can be retracted into the valve-related delivery system, so as to facilitate the readjustment of the valve release position.

[0107] like Figures 1A to 25 As shown, in some embodiments of the stent 1 for interventional valve replacement, the first connection end 11F includes a plurality of first turning portions 11A facing the second grid stent portion 12; the second connection end 12F includes a plurality of second turning portions 12A facing the first grid stent portion 11. At least part of the first turning portions 11A and at least part of the second turning portions 12A are respectively and movably connected relative to each other.

[0108] At least part of the first turning portion 11A and at least part of the second turning portion 12A are respectively and movably connected relative to each other, which is beneficial for the second grid stent portion 12 to withstand greater deformation, so that the stent 1 can better disperse stress concentration, thereby being more conducive to improving the fatigue life of the interventional replacement valve.

[0109] like Figure 5A and5B , FIG. 11A to FIG. 12B , Figures 23 to 24 As shown, in the stent 1 of an interventional valve replacement in some embodiments, in the first turning portion 11A and the second turning portion 12A that are relatively and movably connected, a side of at least one first turning portion 11A facing the corresponding second turning portion 12A abuts against a side of the corresponding second turning portion 12A facing the first turning portion 11A.

[0110] The side of the first turning portion 11A facing the second turning portion 12A abuts against the side of the second turning portion 12A facing the first turning portion 11A, so that the second turning portion 12A to which the first turning portion 11A is movably connected has a simple structure and is easy to connect.

[0111] like FIG. 11A to FIG. 12B , Figures 23 to 24 As shown, in some embodiments of the stent 1 for interventional valve replacement, in the first turning portion 11A and the second turning portion 12A that are relatively and movably connected, a side of at least one first turning portion 11A facing the corresponding second turning portion 12A includes a recessed portion 119 recessed toward a side away from the second turning portion 12A, and the corresponding second turning portion 12A is located in the recessed portion 119.

[0112] The side of the first turning portion 11A facing the corresponding second turning portion 12A includes a recessed portion 119 that is recessed toward the side away from the second turning portion 12A. The corresponding second turning portion 12A is located in the recessed portion 119, which is beneficial to maintaining the relative position stability of the first grid stent portion 11 and the second grid stent portion 12 in the circumferential and longitudinal directions, and reducing the possibility of twisting and / or overlapping along the longitudinal direction of the stent 1 and the interventional replacement valve after implantation into the human body.

[0113] like 6A to 10D As shown, in the stent 1 of an interventional valve replacement in some embodiments, among the first turning portion 11A and the second turning portion 12A which are relatively and movably connected, at least one first turning portion 11A is provided with a wire mounting hole 116 or a wire mounting groove 117, so that the wire of the corresponding second turning portion 12A is mounted in the wire mounting hole 116 or the wire mounting groove 117.

[0114] The first turning portion 11A has a wire installation hole 116 or a wire installation groove 117, which is conducive to maintaining the relative position stability of the first grid bracket portion 11 and the second grid bracket portion 12 on the basis of having a required amount of movement between the first grid bracket portion 11 and the second grid bracket portion 12 in a certain dimension.

[0115] like 6A to 10DAs shown, in some embodiments of the stent 1 for interventional valve replacement, the first grid stent portion 11 includes a stent rod 112 forming a first main body and a connecting portion 115 arranged on the stent rod 112, and a wire mounting hole 116 or a wire mounting groove 117 is arranged on the connecting portion 115; and / or the wire mounting hole 116 or the wire mounting groove 117 extends along the circumference of the stent 1; and / or the dimension of the wire mounting hole 116 perpendicular to its extension direction or the width of the wire mounting groove 117 is greater than the dimension of the wire forming the second turning portion 12A in the corresponding direction, so that the wire forming the second turning portion 12A has a movable margin in the wire mounting hole 116 or the wire mounting groove 117.

[0116] In the case of providing the connection part 115, the connection part 115 and the wire installation hole 116 or the wire installation groove 117 thereon can be made integrally with the first body by cutting, or the connection part 115 and the wire installation hole 116 or the wire installation groove 117 thereon can be processed separately and then the connection part 115 is connected to the first body. 7A to 10D As shown, in some embodiments of the stent 1 for interventional valve replacement, the opening of the wire installation groove 117 is formed on the radial inner side of the first grid stent portion 11; or the opening of the wire installation groove 117 is formed on the side of the first grid stent portion 11 facing the second grid stent portion 12.

[0117] By setting the opening of the wire installation groove 117 in the above direction, it is beneficial to reasonably control the movable dimension and the relative position stability dimension between the first grid bracket part 11 and the second grid bracket part 12; at the same time, it is beneficial to recover the bracket 1 when the release position of the bracket 1 is inaccurate during the operation.

[0118] like Figures 13 to 15D As shown, in some embodiments of the stent 1 for interventional valve replacement, in at least one of the first turning portion 11A and the second turning portion 12A that are relatively and movably connected, a boss mounting hole 116' or a boss mounting groove 117' is provided on the side of the first turning portion 11A facing the corresponding second turning portion 12A, and the second turning portion 12A has a boss 122 connected to the wire forming the second turning portion 12A, and the boss 122 is installed in the boss mounting hole 116' or the boss mounting groove 117'.

[0119] The first transition portion 11A has a protrusion mounting hole 116 ′ or a protrusion mounting groove 117 ′, and the second transition portion 12A has a protrusion 122 , which is conducive to reasonably controlling the movable dimension and relative position stability dimension between the first grid bracket portion 11 and the second grid bracket portion 12 .

[0120] like FIG. 14A to FIG. 15DAs shown, in some embodiments of the stent 1 for interventional valve replacement, the first grid stent portion 11 includes a stent rod 112 forming a grid and a connecting portion 115 provided on the stent rod 112, and a boss mounting hole 116' or a boss mounting groove 117' is provided on the connecting portion 115; and / or the boss mounting hole 116' or the boss mounting groove 117' extends along the length direction of the stent 1; and / or the dimension of the boss mounting hole 116' perpendicular to its extension direction or the width of the boss mounting groove 117' is greater than the dimension of the boss 122 in the corresponding direction, so that the boss 122 has a movable margin in the boss mounting hole 116' or the boss mounting groove 117'; and / or the dimension of the boss mounting hole 116' along its extension direction or the dimension of the boss mounting groove 117' along its extension direction is greater than the dimension of the boss 122 in the corresponding direction.

[0121] In the case of providing the connection part 115, the connection part 115 and the boss mounting hole 116' or the boss mounting groove 117' thereon can be made integrally with the first body by cutting, or the connection part 115 and the boss mounting hole 116' or the boss mounting groove 117' thereon can be processed separately and then the connection part 115 is connected to the first body. Figures 13 to 15D As shown, in the stent 1 for interventional valve replacement in some embodiments, the protrusion 122 extends from the wire of the second turning portion 12A toward the first turning portion 11A.

[0122] The protrusion 122 extends from the wire of the second turning portion 12A toward the first turning portion 11A to stabilize the relative position of the first grid support portion 11 and the second grid support portion 12 along the length direction of the support 1 and perpendicular to the length direction. The protrusion 122 can be made of the same wire as the wavy ring 121 forming the second grid support portion 12.

[0123] like FIG. 15A to FIG. 15D As shown, in some embodiments of the stent 1 for interventional valve replacement, the opening of the protrusion mounting groove 117 ′ is formed on the radial inner side of the first grid stent part 11 and on the side facing the second grid stent part 12 .

[0124] Reasonable setting of the opening direction of the protrusion mounting groove 117' is conducive to reasonable control of the movable dimension and relative position stability dimension between the first grid bracket part 11 and the second grid bracket part 12; at the same time, it is conducive to recovering the bracket 1 when the release position of the bracket 1 is inaccurate during the operation.

[0125] In some embodiments of the stent 1 for interventional valve replacement, for example Figures 6A to 10D , Figures 14A to 15DIn the illustrated embodiment, the connection portion 115 and the support rod 112 may be connected in an integrated manner or in a split manner. The integrated connection has high requirements for laser cutting and requires laser etching of local fine structures. When a split connection is adopted, the connection portion 115 may be prefabricated in advance, and the wire mounting hole 116, the wire mounting groove 117, the raised portion mounting hole 116' or the raised portion mounting groove 117' may be made at the same time, and then connected to the support rod 112 by nesting, perforation or welding.

[0126] In the stent 1 for interventional valve replacement in some embodiments, the first lattice stent portion 11 is directly connected to the second lattice stent portion 12 and / or connected via sutures.

[0127] For example, FIG. 6A to FIG. 6B In the illustrated embodiment, the first grid support portion 11 is directly connected to the second grid support portion 12 without being connected by sutures. FIG. 5A to FIG. 5B , FIG. 11A to FIG. 12B In the illustrated embodiment, the first grid stent portion 11 and the second grid stent portion 12 are connected by sutures, wherein the sutures may connect the first grid stent portion 11 and the second grid stent portion 12 alone, or may connect the first grid stent portion 11 and the second grid stent portion 12 while connecting the sealing membrane 2 or the valve 3 . 7A to 10D , FIG. 14A to FIG. 15D In the illustrated embodiment, the first grid support portion 11 is directly connected to the second grid support portion 12 and / or connected via sutures.

[0128] like Figures 8A to 8C , FIG. 10A to FIG. 10D , FIG. 12A to FIG. 12B As shown, in some embodiments of the stent 1 for interventional valve replacement, the first lattice stent portion 11 includes suture holes 118 for passing sutures.

[0129] The suture perforations 118 are provided to facilitate the positional definition of the sutures connecting the first grid support portion 11 and the second grid support portion 12 , so that the relative positions of the first grid support portion 11 and the second grid support portion 12 are stable when they are connected by sutures.

[0130] like Figures 8A to 8C , FIG. 10A to FIG. 10D , FIG. 12A to FIG. 12B As shown, in some embodiments of the stent 1 for interventional valve replacement, the first grid stent portion 11 includes a stent rod 112 forming a first main body, and a suture perforation 118 is arranged on the stent rod 112; and / or the first grid stent portion 11 includes a stent rod 112 forming a first main body and a connecting portion 115 arranged on the stent rod 112, and the suture perforation 118 is arranged on the connecting portion 115.

[0131] like Figures 8A to 8C , FIG. 10A to FIG. 10D , FIG. 12A to FIG. 12B As shown, in some embodiments of the stent 1 for interventional valve replacement, the first connection end 11F of the first body includes a plurality of first turning portions 11A facing the second grid stent portion 12, the second grid stent portion 12 is connected to at least a portion of the first turning portions 11A, and the suture perforations 118 are arranged at at least a portion of the first turning portions 11A connected to the second grid stent portion 12.

[0132] like Figures 1A to 3 , Figures 16 to 19 As shown, in some embodiments of the stent 1 for interventional valve replacement, the stent 1 has a first expanded diameter section 1A, a cylindrical section 1B and a second expanded diameter section 1C along the length direction, the first expanded diameter section 1A gradually increases in diameter from the cylindrical section 1B to an end away from the cylindrical section 1B, the large head end of the first expanded diameter section 1A forms a first free end 11E, the first grid stent portion includes the first expanded diameter section 1A and the cylindrical section 1B, the second expanded diameter section 1C gradually increases in diameter from the cylindrical section 1B to an end away from the cylindrical section 1B, the second grid stent portion 12 includes the second expanded diameter section 1C, and the large head end of the second expanded diameter section 1C forms a second free end 12E.

[0133] The stent 1 has a first enlarged diameter section 1A, a cylindrical section 1B and a second enlarged diameter section 1C along the length direction, which is conducive to the shape and size of the interventional replacement valve being consistent with the structure of the human cavity to be inserted, and is conducive to reliable fixation with the human cavity.

[0134] like Figures 1A to 3 , Figures 16 to 19 As shown, in some embodiments of the stent 1 for interventional valve replacement, the portion of the first body located at the first diameter expansion section and the portion of the first body located between the cylindrical sections are connected by a plurality of first connecting rods 113. The number of the first connecting rods 113 may be 3 to 15, for example.

[0135] like Figures 1A to 3 , Figures 16 to 19 As shown, in some embodiments of the stent 1 for interventional valve replacement, the second body includes one or more wavy rings 121 arranged along the length direction, wherein the second grid stent portion 12 is conical or transitions from conical to cylindrical.

[0136] like Figures 1A to 3 , Figures 16 to 19 As shown, in some embodiments of the stent 1 for interventional replacement valves, at least some of the one or more wavy rings 121 are conical wavy rings; and / or at least some of the one or more wavy rings 121 are cylindrical wavy rings; and / or at least some of the one or more wavy rings 121 include conical wavy ring segments arranged along the length direction and cylindrical wavy ring segments located on the side of the conical wavy ring segments away from the first grid stent portion 11.

[0137] like Figures 1A to 3 , Figures 16 to 24 As shown, in some embodiments of the stent 1 for interventional valve replacement, the second body includes one or more wavy rings 121 arranged along the length direction, wherein, among the one or more wavy rings 121, the waveform of at least one wavy ring 121 is a waveform of equal amplitude; and / or among the one or more wavy rings 121, the waveform of at least one wavy ring 121 is a waveform of variable amplitude.

[0138] The waveform of at least one wavy ring 121 is a constant-amplitude waveform, which is conducive to the second grid stent part 12 forming a desired shape. The waveform of at least one wavy ring 121 is a variable-amplitude waveform, which is conducive to the second grid stent part 12 meeting more functions, such as better adapting to the shape of the human lumen, facilitating the recovery of the stent 1 when the release position of the stent 1 is inaccurate during surgery, etc.

[0139] In some embodiments of the stent 1 for interventional valve replacement, Fig. 22 As shown, among the more than one wavy rings 121, the waveform of at least one wavy ring 121 is a variable amplitude waveform with one high and one low alternately arranged; Fig.21 As shown, among the more than one wavy rings 121, the waveform of at least one wavy ring 121 is a variable amplitude waveform with one high and two lows arranged alternately; Fig.23 and Fig.24 As shown, among the more than one wavy rings 121, the waveform of at least one wavy ring 121 is a variable amplitude waveform with two highs and one low alternately arranged.

[0140] In some embodiments of the stent 1 for interventional valve replacement, Fig.21 and Fig. 22 As shown, the waveform of the wavy ring 121 farthest from the first grid support part 11 is a variable amplitude waveform; and / or as Fig.23 and Fig.24 As shown, the waveform of the wavy ring 121 closest to the first grid support portion 11 is a variable amplitude waveform.

[0141] In some embodiments of the stent 1 for interventional valve replacement, the number of the wavy rings 121 is less than five.

[0142] Reasonable setting of the number of the wavy rings 121 is conducive to the second grid support part 12 having a suitable size and supporting force.

[0143] like Figures 1A to 3 , Figures 16 to 24 As shown, in some embodiments of the stent 1 for interventional valve replacement, the second body includes two or more wavy rings 121 arranged along the length direction, wherein the wavy turning parts on opposite sides of at least two adjacent wavy rings 121 correspond one to one; and / or the wavy turning parts on opposite sides of at least two phases of the wavy rings 121 are staggered.

[0144] like Fig.23 and Fig.24 As shown, in some embodiments of the stent 1 for interventional valve replacement, the first connection end 11F includes a plurality of first turning portions 11A facing the second grid stent portion 12; the second connection end 12F includes a plurality of second turning portions 12A facing the first grid stent portion 11, and at least part of the first turning portions 11A and at least part of the second turning portions 12A are respectively and fixedly connected relative to each other.

[0145] At least part of the first turning portion 11A and at least part of the second turning portion 12A are respectively and fixedly connected relative to each other, so as to satisfy the required deformation of the bracket 1 while trying to maintain the relative position stability between the first grid bracket portion 11 and the second grid bracket portion 12 .

[0146] like Fig.23 and Fig.24 As shown, in some embodiments of the stent 1 for interventional valve replacement, at least a portion of the first turning portion 11A and at least a portion of the second turning portion 12A are respectively relatively and movably connected, and the top end of the second turning portion 12A of the first turning portion 11A and the second turning portion 12A that are relatively and movably connected facing the first grid stent portion 11 is closer to the first grid stent portion 11 than the top end of the second turning portion 12A of the first turning portion 11A and the second turning portion 12A that are relatively and fixedly connected facing the first grid stent portion 11.

[0147] The above arrangement facilitates the recovery of the stent 1 when the release position of the stent 1 is inaccurate during surgery.

[0148] like Figure 23 to Figure 24 As shown, in some embodiments of the stent 1 for interventional valve replacement, the first turning portion 11A and the second turning portion 12A that are relatively and fixedly connected are connected by a second connecting rod, and the top end of the second turning portion 12A facing the first grid stent portion 11 of the relatively and movably connected first turning portion 11A and the second turning portion 12A is closer to the first grid stent portion 11 than the end of the second connecting rod close to the first grid stent portion 11.

[0149] The above arrangement facilitates the recovery of the stent 1 when the release position of the stent 1 is inaccurate during surgery.

[0150] like Figure 23 to Figure 24 As shown, in some embodiments of the stent 1 for interventional valve replacement, the first turning portion 11A and the second turning portion 12A, which are relatively and fixedly connected, are connected by a second connecting rod.

[0151] In some embodiments of the stent 1 for interventional valve replacement, Fig.23As shown, at least part of the second connecting rod is a straight rod 13 that is connected to the first turning portion 11A and the second turning portion 12A that are relatively and fixedly connected.

[0152] like Fig.24 As shown, at least part of the second connecting rod is a curved rod, and the curved rod is an S-shaped rod 13'.

[0153] Compared with the straight rod 13 , the curved rod and the S-shaped rod have the advantage of buffering the pressure exerted on the stent 1 in the lumen after installation.

[0154] In the stent 1 for interventional valve replacement in some embodiments, the tube is a nickel-titanium alloy tube; and / or the wire is a nickel-titanium alloy wire.

[0155] like Figures 1A to 3 , Figures 16 to 19 As shown, in some embodiments of the stent 1 for the interventional replacement valve, the first free end 11E has a plurality of first connecting ears 111 evenly distributed along the circumference of the interventional replacement valve. Fig.25 As shown, in some embodiments of the stent 1 for an interventional replacement valve, the second free end 12E is provided with a plurality of second connecting ears 129 evenly distributed along the circumference of the interventional replacement valve.

[0156] In some embodiments of the stent 1 for interventional valve replacement, the number of the first connecting ears 111 or the second connecting ears 129 is 3-15.

[0157] like Figures 1A to 3 , Figures 16 to 19 As shown, in some embodiments of the stent 1 for interventional valve replacement, the first grid stent portion 11 includes a multi-layer grid arranged along the length direction formed by a plurality of stent rods 112, and the stent rods 112 of each grid layer are different in length and / or width from the stent rods 112 of the remaining grid layers.

[0158] The length and / or width of the support rods 112 of each grid layer are different from those of the support rods 112 of the remaining grid layers, which is beneficial for the support 1 to form a desired shape and support capacity after being unfolded.

[0159] like Figures 1A to 3 , Figures 16 to 19 As shown, in some embodiments of the stent 1 for interventional valve replacement, the number of grids in the first grid stent portion 11 is 9-15; and / or the number of grids in the second grid stent portion 12 is 9-15.

[0160] like Figures 1A to 3 , Figures 16 to 19As shown, in some embodiments of the stent 1 for interventional valve replacement, the stent 1 has a first expanded diameter section 1A, a cylindrical section 1B and a second expanded diameter section 1C along the length direction, the first expanded diameter section 1A gradually increases in diameter from the cylindrical section 1B to an end away from the cylindrical section 1B, the large end of the first expanded diameter section 1A forms a first free end 11E, the first grid stent portion 11 includes the first expanded diameter section 1A and the cylindrical section 1B, the second expanded diameter section 1C gradually increases in diameter from the cylindrical section 1B to an end away from the cylindrical section 1B, the second grid stent portion 12 includes the second expanded diameter section 1C, the large end of the second expanded diameter section 1C forms a second free end 12E, and the cylindrical section 1B is provided with a fixing groove 114 for installing a developing material.

[0161] A fixing groove 114 for mounting the developer material is disposed on the columnar section 1B, which facilitates the developer material to be stably connected to the bracket 1 .

[0162] like Figure 1A and Figure 1B As shown, the interventional replacement valve of the embodiment of the present application comprises a stent 1, a sealing membrane 2 and a valve leaflet 3. The stent 1 is the stent 1 of the interventional replacement valve of the embodiment of the present application.

[0163] like Figure 1A and Figure 1B As shown, in some embodiments of the interventional replacement valve, the stent 1 has a first diameter expansion section 1A, a cylindrical section 1B and a second diameter expansion section 1C along the length direction. The diameter of the first diameter expansion section 1A gradually increases from the cylindrical section 1B to the end away from the cylindrical section 1B, and the large end of the first diameter expansion section 1A forms a first free end 11E. The first grid stent part 11 includes the first diameter expansion section 1A and the cylindrical section 1B, and the diameter of the second diameter expansion section 1C gradually increases from the cylindrical section 1B to the end away from the cylindrical section 1B. The second grid stent part 12 includes the second diameter expansion section 1C, and the large end of the second diameter expansion section 1C forms a second free end 12E. The sealing membrane 2 is fixed to the inner periphery of the stent 1 by sutures. The arc of the leaflet 3 is sutured on the cylindrical section 1B.

[0164] The arc of the leaflet 3 is sutured on the cylindrical segment 1B, which is beneficial to the stable connection between the leaflet 3 and the stent 1 and helps to reduce the risk of tearing at the suture during long-term operation of the leaflet 3.

[0165] like Figure 1A and Figure 1B As shown, in some embodiments of the interventional replacement valve, the first grid stent portion 11 includes a multi-layer grid arranged along the length direction formed by a plurality of stent rods 112; the number of leaflets 3 is three, the leaflets are semilunar in shape, and the two sides of the leaflets are sutured in pairs and fixed on the first connecting rod 113 of the cylindrical segment 1B.

[0166] In the interventional replacement valve of some embodiments, the material of the valve leaflets is a polymer material or biological tissue; and / or the material of the sealing membrane is a polymer material or biological tissue.

[0167] In some embodiments of the interventional replacement valve, the interventional replacement valve includes a developing material disposed on the fixing groove 114 of the stent 1 , and the developing material is, for example, nickel-titanium alloy.

[0168] The following combination Figures 1A to 24 The interventional replacement valve and stent 1 provided in the present application are further described.

[0169] like Figure 1A and Figure 1B As shown, the interventional replacement valve is a pulmonary valve, including a stent 1, a sealing membrane 2 and a leaflet 3. The interventional replacement valve as a whole presents a structure with large ends and a small middle. The stent 1 is a segmented structure, in which the proximal end of the stent is a cross-closed grid structure formed by a stent rod 112. The closed grid structure is used as the first grid stent part 11, which is made of a nickel-titanium alloy tube by laser cutting. The closed grid structure is divided into two sections, including a first layer of grids and a second layer of grids in sequence. The first layer of grids and the second layer of grids are connected by a plurality of first connecting rods 113. The first layer of grids transitions from a conical shape to a cylindrical shape, serving as the first diameter expansion section 1A. The second layer of grids is columnar, serving as the columnar section 1B. The outer end of the first layer of grids is provided with a plurality of evenly distributed first connecting ears 111 for assembly. The stent rod 112 of the second layer of grids is provided with a fixing groove 114 for installing a developing material, and the developing material is a nickel-titanium alloy material.

[0170] like Figures 1A to 3 , Figures 16 to 19 As shown, the distal end of the stent is in a conical transition to a cylindrical or conical shape. The distal end of the stent includes a plurality of metal rings of wavy annular sinusoidal structures, namely, wavy rings 121, and each wavy ring 121 is similar to a corolla.

[0171] like Figures 1A to 3 , Figures 16 to 19 As shown, in the implementation of the present application, two wavy rings 121 form a third layer of mesh. The third layer of mesh serves as the second diameter expansion section 1C and the second mesh support portion 12. In an embodiment not shown, the wavy rings 121 may be other numbers, for example, 1 to 5.

[0172] A sealing film 2 is installed on the inner side of each layer of mesh of the stent 1, and the sealing film 2 is sutured and fixed around the inner side of the stent 1. The leaflets 3 are fixed on the second layer of mesh, and the arc of the leaflets 3 is sutured on the second layer of mesh. There are three leaflets 3, and the leaflets 3 are in a semi-lunar structure. The two sides of the leaflets 3 are sutured and fixed on the first connecting rod 113 in pairs, and the arc of the leaflets 3 is sutured on the second layer of mesh. The materials of the leaflets 3 and the sealing film 2 can be polymer materials, such as PET, e-PTFE, etc., or biological tissues, such as bovine pericardium, porcine pericardium, etc.

[0173] The number of grids at the proximal end of the stent is any number from nine to fifteen. The number of grids at the distal end of the stent is any number from nine to fifteen. The number of first connecting rods 113 between the first layer of grids and the second layer of grids is any number from three to fifteen. The number of first connecting ears 111 of the stent 1 is any number from three to fifteen.

[0174] like Figures 1A to 3 , Figures 16 to 19 As shown, the stent rods 112 of each layer of grid units at the proximal end of the stent have different lengths and widths, so that the stent 1 can form a desired shape and support capacity after being deployed.

[0175] like Figures 1A to 3 , Figures 16 to 19 As shown, the wavy ring 121 at the distal end of the stent is formed by bending a round metal wire.

[0176] like Figure 4 As shown, the second turning portion 12A is a turning point of the wavy ring 121 close to the first grid bracket portion 12 toward the first grid bracket portion 12 .

[0177] FIG. 5A to FIG. 12B The second grid support portion 12 in the support 1 of the embodiment shown has Figure 4 The second transition portion 12A is shown.

[0178] FIG. 5A to FIG. 5B In the illustrated embodiment, each first transition portion 11A is opposite to each second transition portion 12A and is movably connected.

[0179] The proximal end portion and the distal end portion of the stent are both pure rhombus grids, and the side of the first turning portion 11A facing the second turning portion 12A abuts against the side of the second turning portion 12A facing the first turning portion 11A, that is, there is no fixed constraint between the proximal end portion and the distal end portion of the stent, and the two are connected together with the sealing membrane 2 by sutures.

[0180] Fig. 6A and Figure 6B In the illustrated embodiment, each first transition portion 11A is opposite to each second transition portion 12A and is movably connected.

[0181] The first turning portion 11A has a wire installation hole 116 , and the wire forming the second turning portion 12A is installed in the wire installation hole 116 .

[0182] In this embodiment, a connecting portion 115 is provided on the first turning portion 11A, and a wire mounting hole 116 is provided on the connecting portion 115. The connecting portion 115 is, for example, a rectangular connecting block. The connecting portion 115 is beneficial for preventing the wire mounting hole provided on the bracket rod 112 from affecting the overall strength of the bracket 1.

[0183] The wire installation hole 116 is a circular through hole provided on the connection part 115 and extending along the circumference of the stent 1. The diameter of the circular through hole is larger than the diameter of the metal wire forming the second body of the second grid stent part 12, which is conducive to reducing the constraint of the proximal end of the stent on the wavy ring 121 of the distal end of the stent.

[0184] FIG. 7A to FIG. 7C In the illustrated embodiment, each first transition portion 11A is opposite to each second transition portion 12A and is movably connected.

[0185] The first turning portion 11A has a wire installation groove 117 , and the wire forming the second turning portion 12A is installed in the wire installation groove 117 .

[0186] The opening of the wire installation groove 117 is formed on a side of the first grid bracket portion 11 facing the second grid bracket portion 12 .

[0187] In this embodiment, a connecting portion 115 is disposed on the first turning portion 11A, and a wire installation groove 117 is disposed on the connecting portion 115. The connecting portion 115 is, for example, a rectangular parallelepiped connecting block.

[0188] The wire installation groove 117 is a U-shaped groove provided on the connecting portion 115 and extending along the circumferential direction of the stent 1. The metal wire forming the second turning portion 12A is clamped in the U-shaped groove and connected to the connecting portion 115. The width of the U-shaped groove is larger than the diameter of the metal wire, which is conducive to reducing the constraint of the proximal end of the stent on the wavy ring 121 of the distal end of the stent.

[0189] There is limited constraint between the proximal end portion of the stent and the distal end portion of the stent, and the two are connected together with the sealing membrane 2 through sutures.

[0190] FIG. 8A to FIG. 8C The embodiment shown is FIG. 7A to FIG. 7C The embodiment shown is different in that the first grid support portion 11 has a suture hole 118 for passing a suture. The suture hole 118 is provided at least partially in the first transition portion 11A connected to the second grid support portion 12. FIG. 8A to FIG. 8CAs shown, two suture holes 118 are arranged side by side along the circumference of the stent 1 on a side of the wire installation groove 117 of the connecting portion 115 away from the first grid stent portion 12 .

[0191] There is limited constraint between the proximal end portion of the stent and the distal end portion of the stent, and the two are connected together with the sealing membrane 2 by sutures. The sutures pass through the suture perforations 118, which facilitates better positioning of the sutures.

[0192] FIG. 8A to FIG. 8C The embodiment shown is FIG. 7A to FIG. 7C The same parts of the embodiments shown can be referred to FIG. 7A to FIG. 7C Description of the illustrated embodiment.

[0193] 9A to 9D In the illustrated embodiment, each first transition portion 11A is opposite to each second transition portion 12A and is movably connected.

[0194] The first turning portion 11A has a wire installation groove 117 , and the wire forming the second turning portion 12A is installed in the wire installation groove 117 .

[0195] The opening of the wire installation groove 117 is formed at the radial inner side of the first grid bracket part 11 .

[0196] In this embodiment, a connecting portion 115 is disposed on the first turning portion 11A, and a wire installation groove 117 is disposed on the connecting portion 115. The connecting portion 115 is, for example, a rectangular parallelepiped connecting block.

[0197] The wire installation groove 117 is a U-shaped groove provided on the connecting portion 115 and extending along the circumferential direction of the stent 1. The metal wire forming the second turning portion 12A is clamped in the U-shaped groove and connected to the connecting portion 115. The width of the U-shaped groove is larger than the diameter of the metal wire, which is conducive to reducing the constraint of the proximal end of the stent on the wavy ring 121 of the distal end of the stent.

[0198] There is a limited constraint between the proximal end portion of the stent and the distal end portion of the stent, and the two are connected together with the sealing membrane 2 through sutures. Since the second turning portion 12A adopts an inner buckle assembly structure relative to the first turning portion 11A, it is convenient to recover the stent 1 when the release position of the stent 1 is inaccurate during the operation.

[0199] FIG. 10A to FIG. 10D The embodiment shown is 9A to 9C The embodiment shown is different in that the first grid support portion 11 has a suture hole 118 for passing a suture. The suture hole 118 is provided at least partially in the first transition portion 11A connected to the second grid support portion 12. FIG. 10A to FIG. 10DAs shown, four suture perforations 118 are arranged in groups of two on the side of the wire installation groove 117 of the connecting portion 115 away from the first grid bracket portion 12 and the side close to the first grid bracket portion 12, and the two suture perforations 118 in each group are arranged side by side along the circumference of the bracket 1.

[0200] There is limited constraint between the proximal end portion of the stent and the distal end portion of the stent, and the two are connected together with the sealing membrane 2 by sutures. The sutures pass through the suture perforations 118, which facilitates better positioning of the sutures.

[0201] FIG. 10A to FIG. 10D The embodiment shown is 9A to 9D The same parts of the embodiments shown can be referred to 9A to 9D Description of the illustrated embodiment.

[0202] Fig.11A and Fig. 11B In the illustrated embodiment, each first transition portion 11A is opposite to each second transition portion 12A and is movably connected.

[0203] The side of the first transition portion 11A facing the second transition portion 12A abuts against the side of the second transition portion 12A facing the first transition portion 11A, and the side of the first transition portion 11A facing the second transition portion 12A includes a recessed portion 119 recessed toward the side away from the second transition portion 12A, and the second transition portion 12A is located in the recessed portion 119. The recessed portion 119 forms a V-shaped structure that roughly matches the second transition portion 12A.

[0204] There is limited constraint between the proximal end portion of the stent and the distal end portion of the stent, and the two are connected together with the sealing membrane 2 through sutures.

[0205] Fig. 12A and Fig. 12B The embodiment shown is Fig.11A and Fig. 11B The embodiment shown is different in that the first grid support part 11 has a suture perforation 118 for passing a suture. The suture perforation 118 is arranged at the connection between the rod end of the support rod 112 of at least part of the first transition part 11A connected to the second grid support part 12 and the V-shaped structure. Two suture perforations 118 are arranged side by side along the circumference of the support 1.

[0206] There is limited constraint between the proximal end portion of the stent and the distal end portion of the stent, and the two are connected together with the sealing membrane 2 by sutures. The sutures pass through the suture perforations 118, which facilitates better positioning of the sutures.

[0207] Fig. 12A and Fig. 12B The embodiment shown is Fig.11A and Fig. 11B The same parts of the embodiments shown can be referred to Fig.11A and Fig. 11B Description of the illustrated embodiment.

[0208] like Fig.13 As shown, the second turning portion 12A of the wavy ring 121 has a protrusion 122 connected to the wire forming the second turning portion 12A. The protrusion 122 extends from the wire of the second turning portion 12A toward the first turning portion 11A. The protrusion 122 is, for example, formed of the same wire as the wavy ring 121. The protrusion 122 can be fixedly connected to the wire forming the second turning portion 12A by welding.

[0209] FIG. 14A to FIG. 15D The second grid bracket portion 12 in the bracket 1 of the illustrated embodiment has a protrusion 122 as shown in FIG. 15 .

[0210] FIG. 14A to FIG. 14D In the illustrated embodiment, each first transition portion 11A is opposite to each second transition portion 12A and is movably connected.

[0211] The first turning portion 11A has a protrusion mounting hole 116 ′, and the second turning portion 12A has a protrusion 122 connected to the wire forming the second turning portion 12A, and the protrusion 122 is mounted in the protrusion mounting hole 116 ′.

[0212] The protrusion mounting hole 116' is a circular hole extending along the length direction of the bracket 1. The opening of the protrusion mounting hole 116' is on the side facing the second transition portion 12A. When connecting the first grid bracket portion 11 and the second grid bracket portion 12, the protrusion 122 is inserted into the circular hole to achieve the connection and matching between the two.

[0213] The diameter of the circular hole is larger than the diameter of the protrusion 122 , and the depth of the circular hole is smaller than the length of the protrusion 122 , which helps to reduce the constraint of the proximal end of the stent on the wavy ring 121 of the distal end of the stent.

[0214] FIG. 15A to FIG. 15D In the illustrated embodiment, each first transition portion 11A is opposite to each second transition portion 12A and is movably connected.

[0215] The first turning portion 11A has a protrusion installation groove 117 ′, and the protrusion 122 on the wire rod forming the second turning portion 12A is installed in the protrusion installation groove 117 ′.

[0216] The boss mounting groove 117 ′ extends along the length direction of the bracket 1 , and an opening of the boss mounting groove 117 ′ is formed at the radial inner side of the first grid bracket part 11 and at a side facing the second grid bracket part 12 .

[0217] The protrusion mounting groove 117' is a U-shaped groove. When connecting the first grid bracket part 11 and the second grid bracket part 12, the protrusion 122 is inserted into the U-shaped groove to realize the connection between the first grid bracket part 11 and the second grid bracket part 12. The width of the U-shaped groove is larger than the size of the protrusion 122, and the depth of the U-shaped groove is smaller than the length of the protrusion 122, so as to reduce the constraint of the proximal end part of the bracket on the wavy ring 121 of the distal end part of the bracket.

[0218] Since the second turning portion 12A adopts an inner buckle assembly structure relative to the first turning portion 11A, it is convenient to recover the stent 1 when the release position of the stent 1 is inaccurate during the operation.

[0219] Figures 16 to 19 The structure of the stent 1 for interventional valve replacement according to some embodiments of the present application is shown.

[0220] Fig.16 A schematic diagram of connecting two different layers of wavy rings 121 at the distal end of a stent in one embodiment is shown. The wavy turning parts on opposite sides of the two different layers of wavy rings 121 correspond to each other. At the same time, the distal end of the stent transitions from a conical shape to a cylindrical shape starting from the connection part. The advantage of this structure is that the radial support force of the distal end of the stent is relatively large.

[0221] Fig.17 A schematic diagram of connecting two different layers of wavy rings 121 at the distal end of a stent in one embodiment is shown. The wavy turning parts of the two different layers of wavy rings 121 on opposite sides are arranged in a staggered manner. At the same time, the distal end transitions from a conical shape to a cylindrical shape starting from the connection part. The advantage of this structure is that the distal end of the stent has better flexibility.

[0222] Fig.18 A schematic diagram showing the connection of two different layers of wavy rings 121 at the distal end of a stent according to an embodiment.

[0223] The wave-shaped turning parts of the two different layers of wave-shaped rings 121 on the opposite side are staggered, and the advantage of this structure is that the distal end of the stent has good flexibility. At the same time, the distal end of the stent is divided into a conical shape, which is convenient for fixing the distal end of the stent and has good anti-displacement performance.

[0224] Fig.19 The schematic diagram of the connection of two different layers of wavy rings 121 at the distal end of a stent in one embodiment is shown. The wavy turning parts on the opposite sides of the two different layers of wavy rings 121 correspond to each other. The advantage of this structure is that the radial support force of the distal end of the stent is large enough. At the same time, the distal end of the stent is divided into a conical shape, which facilitates the fixation of the distal end of the stent and has good anti-displacement performance.

[0225] Fig. 20It is a schematic diagram of the structure of the wavy rings of each layer at the distal end of the stent of the interventional replacement valve in some embodiments of the present application, wherein the waveforms of the two wavy rings 121 are equal-amplitude waveforms.

[0226] Fig.21 The structure diagram of the wavy rings of each layer at the distal end of the stent of the interventional replacement valve in some embodiments of the present application is shown. The waveform of one wavy ring 121 close to the first grid stent part 11 is a constant amplitude waveform, and the waveform of the wavy ring 121 far from the first grid stent part 11 is a variable amplitude waveform with one high and two low waveforms arranged alternately.

[0227] Fig. 22 The structure diagram of the wavy ring of the outer layer of the distal end portion of the stent of the interventional replacement valve in some embodiments of the present application is shown in FIG. The waveform of the wavy ring 121 is a variable amplitude waveform with one high and one low alternately arranged.

[0228] Fig.23 It is a schematic diagram of the radially expanded structure of the stent 1 for interventional valve replacement in some embodiments of the present application.

[0229] like Fig.23 As shown, the first connection end 11F of the first body includes a plurality of first turning portions 11A facing the second grid bracket portion 12 ; the second connection end 12F of the second body includes a plurality of second turning portions 12A facing the first grid bracket portion 11 .

[0230] Part of the first turning portion 11A is opposite to each second turning portion 12A and is movably connected. Part of the first turning portion 11A is opposite to at least part of the second turning portion 12A and is fixedly connected.

[0231] In the first transition portion 11A and the second transition portion 12A which are relatively and movably connected, the side of the first transition portion 11A facing the second transition portion 12A abuts against the side of the second transition portion 12A facing the first transition portion 11A, and the side of the first transition portion 11A facing the second transition portion 12A includes a concave portion 119 concave toward the side away from the second transition portion 12A, and the second transition portion 12A is located in the concave portion 119. The concave portion 119 forms a V-shaped structure that substantially matches the second transition portion 12A.

[0232] like Fig.23 As shown, the second body includes two wavy rings 121, and the waveform of one wavy ring 121 close to the proximal end of the stent is a variable amplitude waveform with two high and one low alternating arrangements.

[0233] like Fig.23As shown, the top of the second turning portion 12A facing the first grid support portion 11 in the first turning portion 11A and the second turning portion 12A that are relatively and movably connected is closer to the first grid support portion 11 than the top of the second turning portion 12A facing the first grid support portion 11 in the first turning portion 11A and the second turning portion 12A that are relatively and fixedly connected. The height difference h between the two is as shown in FIG. Fig.23 shown.

[0234] like Fig.23 As shown, in some embodiments of the stent 1 for interventional valve replacement, the first turning portion 11A and the second turning portion 12A that are relatively and fixedly connected are connected by a second connecting rod, and the top end of the second turning portion 12A facing the first grid stent portion 11 of the relatively and movably connected first turning portion 11A and the second turning portion 12A is closer to the first grid stent portion 11 than the end of the second connecting rod close to the first grid stent portion 11.

[0235] like Fig.23 As shown, the first transition portion 11A and the second transition portion 12A which are relatively and fixedly connected are connected by a second connecting rod. Fig.23 In the embodiment shown, the second connecting rod is a straight rod 13. Fig.23 As shown, the height difference h is greater than the length of the projection of the second connecting rod in the length direction of the bracket 1 .

[0236] Fig.23 In the illustrated embodiment, the second body formed by weaving wires and the first body formed by laser cutting of tubular materials can be partially connected by concave-convex embedding of the first turning portion 11A and the second turning portion 12A, and partially the first turning portion 11A and the second turning portion 12A are connected by a second connecting rod. The area where the concave-convex embedded parts are located along the length direction of the stent 1 constitutes the embedding section of the stent 1, and the area where the second connecting rod is located constitutes the transition section of the stent 1. The embedding section is at least partially not in the transition section, and the waveform of the wavy ring 121 on the side of the proximal end of the stent at the distal end of the stent is a variable amplitude waveform with two highs and one low, that is, the lowest point on the side of the proximal end of the stent forms a height difference h, the highest point is connected to the transition section, and the lowest point is interspersed in the second layer of the grid of the proximal end of the stent. The above arrangement facilitates the recovery of the stent 1 when the release position of the stent 1 is inaccurate during the operation.

[0237] Fig.23 In the embodiment shown, only one way in which the first transition portion 11A and the second transition portion 12A are relatively and movably connected is used as an example for explanation. In the embodiment not shown, the aforementioned FIG. 5A to FIG. 12B , FIG. 14A to FIG. 15DAny of the movable connection methods shown in the figure is applicable to the situation where part of the first turning portion 11A is relatively and movably connected to each second turning portion 12A, and part of the first turning portion 11A is relatively and fixedly connected to at least part of the second turning portion 12A.

[0238] Fig.24 It is a schematic diagram of the radially expanded structure of the stent 1 for interventional valve replacement in some embodiments of the present application. Fig.24 The embodiment shown is Fig.23 The difference between the illustrated embodiment is that the second connecting rod is a curved rod, specifically an S-shaped rod 13'. The curved rod and the S-shaped rod are conducive to buffering the pressure on the bracket 1 in the lumen after installation.

[0239] Fig.24 The embodiment shown is Fig.23 The same parts of the embodiments shown can be referred to Fig.23 Description of the illustrated embodiment.

[0240] Fig.25 In the illustrated embodiment, the second connecting ears 129 are disposed at the second free end 12F of the second body. The number of the second connecting ears 129 is any number from three to fifteen.

[0241] In addition, in an embodiment not shown in the figure, each first turning portion 11A may be opposite to and fixedly connected to each second turning portion 12A.

[0242] The above description of various embodiments tends to emphasize the differences between the various embodiments. The same or similar parts can be referenced to each other, and for the sake of brevity, they will not be repeated in this article.

[0243] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present application and not to limit it. Although the present application has been described in detail with reference to the preferred embodiments, ordinary technicians in the relevant field should understand that the specific implementation methods of the present application can still be modified or some technical features can be replaced by equivalents, which should all be included in the scope of the technical solution requested for protection in this application.

Claims

1. A stent (1) for interventional valve replacement, characterized in that: include: The first grid support part (11) comprises a first main body made by cutting a tube, wherein the first main body comprises a first free end (11E) and a first connecting end (11F) which are arranged opposite to each other along the length direction of the support (1); A second grid support portion (12) is arranged at the first connection end (11F) of the first main body along the length direction of the support (1), the second grid support portion (12) comprises a second main body made of braided wire, the second main body comprises a second connection end (12F) and a second free end (12E) arranged opposite to each other along the length direction, the second connection end (12F) is connected to the first connection end (11F).

2. The stent (1) for interventional valve replacement according to claim 1, characterized in that: The first connecting end (11F) comprises a plurality of first turning portions (11A) facing the second grid support portion (12); The second connecting end (12F) comprises a plurality of second turning portions (12A) facing the first grid support portion (11); At least part of the first turning portion (11A) and at least part of the second turning portion (12A) are respectively relatively and movably connected.

3. The stent (1) for interventional valve replacement according to claim 2, characterized in that: Among the first turning parts (11A) and the second turning parts (12A) which are relatively and movably connected, a side of at least one of the first turning parts (11A) facing the corresponding second turning part (12A) abuts against a side of the corresponding second turning part (12A) facing the first turning part (11A).

4. The stent (1) for interventional valve replacement according to claim 3, characterized in that: Among the first turning parts (11A) and the second turning parts (12A) that are relatively and movably connected, at least one of the first turning parts (11A) includes a recessed part (119) on the side facing the corresponding second turning part (12A) that is recessed toward the side away from the second turning part (12A), and the corresponding second turning part (12A) is located in the recessed part (119).

5. The stent (1) for interventional valve replacement according to claim 2, characterized in that: Among the first turning part (11A) and the second turning part (12A) which are relatively and movably connected, at least one of the first turning parts (11A) is provided with a wire installation hole (116) or a wire installation groove (117), and the wire forming the corresponding second turning part (12A) is installed in the wire installation hole (116) or the wire installation groove (117); and / or Among the first turning parts (11A) and the second turning parts (12A) which are relatively and movably connected, at least one of the first turning parts (11A) is provided with a protrusion mounting hole (116') or a protrusion mounting groove (117') on one side facing the corresponding second turning part (12A), and the corresponding second turning part (12A) has a protrusion (122) connected to the wire forming the second turning part (12A), and the protrusion (122) is installed in the protrusion mounting hole (116') or the protrusion mounting groove (117').

6. The stent (1) for interventional valve replacement according to claim 5, characterized in that: The first grid support portion (11) comprises a support rod (112) forming the first main body and a connecting portion (115) provided on the support rod (112), and the wire installation hole (116) or the wire installation groove (117) is provided on the connecting portion (115); and / or The wire installation hole (116) or the wire installation groove (117) extends along the circumference of the bracket (1); and / or The dimension of the wire installation hole (116) perpendicular to its extension direction or the width of the wire installation groove (117) is greater than the dimension of the wire forming the second turning portion (12A) in the corresponding direction, so that the wire forming the second turning portion (12A) has a movable margin in the wire installation hole (116) or the wire installation groove (117); and / or The first grid support portion (11) comprises a support rod (112) forming the first main body and a connecting portion (115) provided on the support rod (112), and the protrusion mounting hole (116') or the protrusion mounting groove (117') is provided on the connecting portion (115); and / or The protrusion mounting hole (116') or the protrusion mounting groove (117') extends along the length direction of the bracket (1); and / or The dimension of the protrusion mounting hole (116') perpendicular to its extension direction or the width of the protrusion mounting groove (117') is greater than the dimension of the protrusion (122) in the corresponding direction, so that the protrusion (122) has a movable margin in the protrusion mounting hole (116') or the protrusion mounting groove (117'); and / or The dimension of the protrusion mounting hole (116') along its extension direction or the dimension of the protrusion mounting groove (117') along its extension direction is greater than the dimension of the protrusion (122) in the corresponding direction.

7. The stent (1) for interventional valve replacement according to claim 6, characterized in that: An opening of at least one of the wire installation grooves (117) is formed on the radial inner side of the first grid support portion (11); and / or An opening of at least one of the wire installation grooves (117) is formed on a side of the first grid support portion (11) facing the second grid support portion (12); and / or At least one of the protrusions (122) extends from the wire of the second turning portion (12A) toward the first turning portion (11A), and an opening of the protrusion mounting groove (117') is formed on the radial inner side of the first grid support portion (11) and on a side facing the second grid support portion (12).

8. The stent (1) for interventional valve replacement according to claim 1, characterized in that: The first grid support part (11) and the second grid support part (12) are directly connected and / or connected via sutures.

9. The stent (1) for interventional valve replacement according to claim 8, characterized in that: The first grid support part (11) comprises a suture hole (118) for passing the suture.

10. The stent (1) for interventional valve replacement according to claim 9, characterized in that: The first grid support portion (11) comprises a support rod (112) forming the first body, and the suture perforation (118) is arranged on the support rod (112); and / or The first grid support portion (11) comprises a support rod (112) forming the first main body and a connecting portion (115) arranged on the support rod (112), and the suture perforation (118) is arranged on the connecting portion (115).

11. The stent (1) for interventional valve replacement according to claim 1, characterized in that: The stent (1) comprises a first diameter-expanding section (1A), a columnar section (1B) and a second diameter-expanding section (1C) along the length direction; the diameter of the first diameter-expanding section (1A) gradually increases from the columnar section (1B) to an end away from the columnar section (1B); the large end of the first diameter-expanding section (1A) forms the first free end (11E); the first grid stent portion (11) comprises the first diameter-expanding section (1A) and the columnar section (1B); the diameter of the second diameter-expanding section (1C) gradually increases from the columnar section (1B) to an end away from the columnar section (1B); the second grid stent portion (12) comprises the second diameter-expanding section (1C); the large end of the second diameter-expanding section (1C) forms the second free end (12E); wherein, The portion of the first main body located in the first expanded diameter section (1A) and the portion of the first main body located between the cylindrical sections (1B) are connected by a plurality of first connecting rods (113); and / or The second body comprises one or more wavy rings (121) arranged along the length direction, wherein the second grid support portion (12) is conical or transitions from conical to cylindrical.

12. The stent (1) for interventional valve replacement according to claim 1, characterized in that: The second body comprises one or more wavy rings (121) arranged along the length direction, wherein: Among the one or more wavy rings (121), the waveform of at least one of the wavy rings (121) is a waveform of equal amplitude; and / or Among the one or more wavy rings (121), the waveform of at least one of the wavy rings (121) is a variable amplitude waveform.

13. The stent (1) for interventional valve replacement according to claim 12, characterized in that: The waveform of the wavy ring (121) farthest from the first grid support portion (11) is a variable amplitude waveform; and / or The waveform of the wavy ring (121) closest to the first grid support portion (11) is a variable amplitude waveform.

14. The stent (1) for interventional valve replacement according to claim 1, characterized in that: The second body comprises two or more wavy rings (121) arranged along the length direction, wherein The wave-shaped turning parts on opposite sides of at least two adjacent wave-shaped rings (121) correspond to each other one by one; and / or The wave-shaped turning parts on opposite sides of at least two adjacent wave-shaped rings (121) are arranged in a staggered manner.

15. The stent (1) for interventional valve replacement according to any one of claims 1 to 14, characterized in that: The first connecting end (11F) comprises a plurality of first turning portions (11A) facing the second grid support portion (12); The second connecting end (12F) comprises a plurality of second turning portions (12A) facing the first grid support portion (11); At least part of the first turning portion (11A) and at least part of the second turning portion (12A) are respectively relatively and fixedly connected.

16. The stent (1) for interventional valve replacement according to claim 15, characterized in that: At least part of the first turning portion (11A) and at least part of the second turning portion (12A) are respectively relatively and movably connected, and the top end of the second turning portion (12A) facing the first grid support portion (11) in the first turning portion (11A) and the second turning portion (12A) that are relatively and movably connected is closer to the first grid support portion (11) than the top end of the second turning portion (12A) facing the first grid support portion (11) in the first turning portion (11A) and the second turning portion (12A) that are relatively and fixedly connected.

17. The stent (1) for interventional valve replacement according to claim 16, characterized in that: The first turning portion (11A) and the second turning portion (12A) which are relatively and fixedly connected are connected via a second connecting rod, and the top end of the second turning portion (12A) facing the first grid bracket portion (11) of the first turning portion (11A) and the second turning portion (12A) which are relatively and movably connected is closer to the first grid bracket portion (11) than an end of the second connecting rod which is close to the first grid bracket portion (11).

18. The stent (1) for interventional valve replacement according to claim 17, characterized in that: The first turning part (11A) and the second turning part (12A) which are relatively and fixedly connected are connected via a second connecting rod.

19. The stent (1) for interventional valve replacement according to any one of claims 1 to 14, characterized in that: The first free end (11E) is provided with a plurality of first connecting ears (111) uniformly distributed along the circumference of the interventional replacement valve; or The second free end (12E) is provided with a plurality of second connecting ears (129) uniformly distributed along the circumference of the interventional replacement valve.

20. The stent (1) for interventional valve replacement according to any one of claims 1 to 14, characterized in that: The first grid support portion (11) comprises a plurality of grid layers formed by a plurality of support rods (112) arranged along the length direction, wherein the support rods (112) of each grid layer have a different length and / or width from the support rods (112) of the remaining grid layers.

21. An interventional replacement valve, comprising a stent (1), a sealing membrane (2) and a valve leaflet (3), characterized in that: The stent (1) is a stent (1) for interventional valve replacement according to any one of claims 1 to 20.

22. The interventional valve replacement according to claim 21, characterized in that: The stent (1) comprises a first diameter-expanding section (1A), a columnar section (1B) and a second diameter-expanding section (1C) along the length direction; the diameter of the first diameter-expanding section (1A) gradually increases from the columnar section (1B) to an end away from the columnar section (1B); the large end of the first diameter-expanding section (1A) forms the first free end (11E); the first grid stent portion (11) comprises the first diameter-expanding section (1A) and the columnar section (1B); the diameter of the second diameter-expanding section (1C) gradually increases from the columnar section (1B) to an end away from the columnar section (1B); the second grid stent portion (12) comprises the second diameter-expanding section (1C); the large end of the second diameter-expanding section (1C) forms the second free end (12E); wherein, The sealing film (2) is fixed to the inner periphery of the stent (1) by suturing; and / or The arc of the leaflet (3) is sutured to the cylindrical segment (1B); and / or The columnar section (1B) is provided with a fixing groove (114) for installing a developing material, and the interventional replacement valve comprises the developing material arranged on the fixing groove (114).

23. The interventional valve replacement according to claim 21, characterized in that: The interventional replacement valve is a pulmonary valve.

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