Composition with effects of controlling oil and removing dandruff and application thereof

Abstract

The invention relates to a composition with effects of controlling oil and removing dandruff and application of the composition. The composition with the effects of controlling oil and removing dandruff comprises sophorolipid, myristicamidopropyl PG-dimethyl ammonium chloride phosphate, creatine, a phellinus linteus extract, a hop extract and sodium chloride. According to the composition, the sophorolipid, the myristicamidopropyl PG-dimethyl ammonium chloride phosphate, the creatine, the phellinus linteus extract, the humulus lupulus extract and the sodium chloride are matched for use, the synergistic interaction effect is achieved, the hair cleaning effect can be achieved, meanwhile, healthy water-oil balance is provided for scalp, and the hair care effect is achieved. The completeness of the scalp barrier is favorably kept, so that the sebum secretion of the scalp is better reduced, and the formation of dandruff is reduced.

Description

Technical Field

[0001] The invention belongs to the technical field of daily cosmetics, and particularly relates to a composition with oil-controlling and anti-dandruff effects and application thereof. Background Art

[0002] In daily life, hair is in close contact with the external environment all the time, facing the test of wind and sun, as well as the invasion of dust and microorganisms in the air. These factors, mixed with the sebum membrane in the hair and scalp, can easily break the natural balance of the scalp, causing various scalp health problems, and become a daily worry for many people. When consumers choose hair care products, oil control and dandruff removal are also hot topics of concern to consumers. Oil control and dandruff removal are two of the efficacy claims allowed for cosmetics in the "Evaluation Standards for Cosmetic Efficacy Claims", so they are also one of the focuses of efficacy research in the entire industry.

[0003] CN118001193A discloses a dandruff-removing, itching-relieving and oil-controlling shampoo and a preparation method thereof. The active ingredients of the invention include amino acid surfactants, alkyl glycosides, selenium disulfide, colloidal sulfur, SAPINDUS MUKUROSSI peel extract, lemon essential oil, sea salt, gentiana SCABRA root extract, bisabolol, PCA zinc, salicylic acid, MELALEUCA ALTERNIFOLIA extract, EPILOBIUM ANGUSTIFOLIUM leaf extract, and ZIZYPHUS JOAZEIRO bark extract. The shampoo prepared by the invention can inhibit the activity of Malassezia furfur and also has a hair care effect.

[0004] CN117257665A discloses an oil-removing and anti-dandruff shampoo and a preparation method thereof, and relates to the technical field of daily chemical products. The oil-removing and anti-dandruff shampoo prepared by the invention is added with an anti-dandruff agent and an oil-removing agent; the anti-dandruff agent is prepared by mixing an anionic composite gel and a dihydromyricetin derivative, the oil-removing agent includes a composite extract, an anionic surfactant and salicylic acid, the anionic composite gel is prepared by reacting the composite gel and 3-chloro-2-hydroxypropyltrimethylammonium chloride, the composite gel includes linseed gum and konjac gum, and the dihydromyricetin derivative is prepared by introducing a triazole sulfonyl group into dihydromyricetin, which not only improves the inhibition rate of Malassezia, further enhances the anti-dandruff effect, but also can achieve the dual effects of hair care and anti-dandruff, the combined extract includes lemon peel extract, sophora flavescens extract, camphor leaf extract and cinnamon bark extract, and the anionic surfactant is sodium lauryl polyether sulfate, which has the effects of oil control and hair care.

[0005] Although there are many oil-controlling and anti-dandruff cleaning products in the prior art, the ingredients used in them are often irritating to the scalp or the scalp bacteria are prone to tolerance after long-term use, thereby losing their due effects. Therefore, there is an urgent need to provide a product with mild ingredients, no irritation and which can keep the hair healthy for a long time to meet the needs of consumers. Summary of the invention

[0006] In view of the deficiencies in the prior art, the object of the present invention is to provide a composition with oil-controlling and anti-dandruff effects and its application.

[0007] In order to achieve the purpose of the invention, the present invention adopts the following technical solutions:

[0008] In a first aspect, the present invention provides a composition with oil-controlling and anti-dandruff effects, wherein the composition with oil-controlling and anti-dandruff effects comprises sophorolipids, myristamidopropyl PG-dimethylammonium chloride phosphate, creatine, medicinal pore fungus extract, hops extract and sodium chloride.

[0009] The sophorolipids in the composition of the present invention can repair the microecological balance of the scalp and effectively reduce the surface tension between water and oil, which enables it to penetrate into the oil layer of the scalp, emulsify and disperse the excess sebum, and then easily remove it through the washing process, which helps to remove excess oil that clogs the pores and reduce the oil basis that provides "nutrients" for the formation of dandruff. In addition, sophorolipids also have certain antibacterial and antifungal properties, which can inhibit the excessive reproduction of certain microorganisms, reduce their decomposition of scalp oil to produce irritating substances and accelerate the process of cell shedding, and control the formation of dandruff to a certain extent.

[0010] The myristamidopropyl PG-dimethylammonium chloride phosphate has excellent emulsifying ability and can effectively interact with excess oil on the scalp to help emulsify and remove excess oil on the scalp surface, thereby controlling the oil secretion of the scalp and achieving an oil control effect.

[0011] The creatine completely blocks the pathway of 5a-reductase turning into the androgen DHT, thereby reducing oil secretion, thereby achieving the purpose of oil control and having a positive effect on scalp health.

[0012] The medicinal fusilli extract is a medicinal mushroom extract grown in Eastern Europe, which has a regulating effect, can help balance the oil secretion of the scalp, reduce excessive oil accumulation, thereby reducing the generation of dandruff and keeping the scalp clean; at the same time, the medicinal fusilli extract has anti-inflammatory and soothing effects, and its anti-inflammatory properties help relieve scalp inflammation, reduce scalp redness, swelling, itching and other problems, and can provide a soothing effect, especially for users with sensitive scalps or scalp inflammation.

[0013] The hop extract has natural anti-inflammatory properties, can help reduce scalp inflammation and irritation, and is particularly effective in relieving sensitive problems such as scalp itching, redness and swelling; at the same time, it can help regulate the oil balance of the scalp. For oily scalps, it can reduce excessive sebum secretion and prevent pores from being clogged, thereby reducing the formation of dandruff.

[0014] The sodium chloride can remove the stratum corneum of the scalp, inhibit oil secretion, and also has anti-inflammatory, antibacterial and antipruritic effects.

[0015] The composition of the present invention has a synergistic effect by using the above six ingredients in combination. While having a cleansing effect on the hair, it can provide a healthy water-oil balance for the scalp, help maintain the integrity of the scalp barrier, and thus better reduce the sebum secretion of the scalp and reduce the formation of dandruff.

[0016] Preferably, the composition with oil-controlling and anti-dandruff effects comprises, by weight, 10-30 parts of sophorolipids, 1-20 parts of myristamidopropyl PG-dimethylammonium chloride phosphate, 1-15 parts of creatine, 0.1-1 parts of medicinal pore fungus extract, 0.1-1 parts of hops extract and 0.1-2 parts of sodium chloride.

[0017] The amount of the sophorolipid added in the composition with oil control and anti-dandruff effect of the present invention can be 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts or 29 parts, etc.;

[0018] The amount of the myristamidopropyl PG-dimethylammonium chloride phosphate added can be 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts or 19 parts, etc.;

[0019] The amount of creatine added can be 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts or 14 parts, etc.;

[0020] The added amount of the medicinal porphyra extract can be 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts or 0.9 parts, etc.;

[0021] The amount of the hop extract added can be 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts or 0.9 parts, etc.;

[0022] The amount of sodium chloride added can be 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 parts, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts, 1.5 parts, 1.6 parts, 1.7 parts, 1.8 parts or 1.9 parts, etc.

[0023] Preferably, the composition with oil-controlling and anti-dandruff effects comprises, by weight, 15-30 parts of sophorolipids, 5-20 parts of myristamidopropyl PG-dimethylammonium chloride phosphate, 5-15 parts of creatine, 0.1-0.8 parts of medicinal pore fungus extract, 0.1-0.8 parts of hops extract and 0.5-2 parts of sodium chloride.

[0024] Preferably, the composition with oil-controlling and anti-dandruff effects comprises, by weight, 15-25 parts of sophorolipids, 10-20 parts of myristamidopropyl PG-dimethylammonium chloride phosphate, 8-13 parts of creatine, 0.1-0.5 parts of medicinal pore fungus extract, 0.1-0.5 parts of hops extract and 1-2 parts of sodium chloride.

[0025] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0026] In a second aspect, the present invention provides a use of the composition with oil-controlling and anti-dandruff effects as described in the first aspect in the preparation of toiletries.

[0027] Preferably, the toiletries are any one of shampoo, conditioner, hair mask, hair oil or hair spray.

[0028] Preferably, the composition with oil-controlling and anti-dandruff effects is added to toiletries in an amount of 1-10% (eg, 2%, 3%, 4%, 5%, 6%, 7%, 8% or 9%, etc.).

[0029] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0030] In a third aspect, the present invention provides an oil-controlling and anti-dandruff shampoo, comprising the composition with oil-controlling and anti-dandruff efficacy as described in the first aspect, a surfactant, a thickener, a chelating agent and water.

[0031] Preferably, the oil-control and anti-dandruff shampoo comprises, by mass percentage, 1-20 parts of the composition with oil-control and anti-dandruff efficacy described in the first aspect, 10-30 parts of a surfactant, 0.1-5 parts of a thickener, 0.1-2 parts of a chelating agent and 50-90 parts of water.

[0032] The amount of the composition with oil-control and anti-dandruff efficacy in the oil-control and anti-dandruff shampoo of the present invention can be 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts or 19 parts, etc.;

[0033] The amount of the surfactant added can be 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts or 29 parts, etc.;

[0034] The thickener may be added in an amount of 0.3 parts, 0.5 parts, 0.7 parts, 0.9 parts, 1 parts, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts or 4.5 parts, etc.;

[0035] The amount of the chelating agent added can be 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 parts, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts, 1.5 parts, 1.6 parts, 1.7 parts, 1.8 parts or 1.9 parts, etc. The amount of water added can be 55 parts, 60 parts, 65 parts, 70 parts, 75 parts, 80 parts, 85 parts or 90 parts, etc.

[0036] Preferably, the surfactant includes any one of a nonionic surfactant, an amphoteric surfactant, an amino acid surfactant or an anionic surfactant, or a combination of at least two thereof.

[0037] Preferably, the surfactant includes a nonionic surfactant, an amphoteric surfactant, an amino acid surfactant and an anionic surfactant.

[0038] Preferably, the nonionic surfactant includes any one of lauryl glucoside, cocamide methyl MEA, PPG-10 sorbitol, trideceth-3, trideceth-7, and trideceth-9, or a combination of at least two thereof.

[0039] Preferably, the amino acid surfactant includes any one of sodium cocoyl aminopropionate, sodium lauroyl sarcosinate, sodium lauroyl oat amino acids or sodium cocoyl apple amino acids, or a combination of at least two thereof.

[0040] Preferably, the amino acid surfactant is a combination of sodium cocoyl aminopropionate, sodium lauroyl sarcosinate, sodium lauroyl oat amino acids and sodium cocoyl apple amino acids.

[0041] Preferably, the anionic surfactant comprises sodium cocoyl isethionate and / or sodium lauryl glycol carboxylate.

[0042] Preferably, the anionic surfactant is a combination of sodium cocoyl isethionate and sodium lauryl glycol carboxylate.

[0043] Preferably, the amphoteric surfactant comprises cocamidopropyl betaine.

[0044] The surfactant in the shampoo of the present invention is selected from nonionic surfactants, amphoteric surfactants, amino acid surfactants and anionic surfactants, which can not only improve the degreasing and decontamination effects of the shampoo, but also improve the foaming property of the shampoo. After use, the shampoo has rich and dense foam, thereby better removing grease and dirt from the scalp.

[0045] Preferably, the thickener is any one of carbomer, xanthan gum, acrylic copolymer, PEG-120 methyl glucose dioleate or guar hydroxypropyltrimonium chloride, or a combination of at least two thereof.

[0046] Preferably, the chelating agent includes any one of EDTA-2Na, EDTA-4Na or tetrasodium glutamate diacetate, or a combination of at least two thereof.

[0047] Preferably, the oil-controlling and anti-dandruff shampoo further comprises any one of a hair conditioner, a moisturizer, a pearlescent agent, a pH regulator, a preservative or a fragrance, or a combination of at least two thereof.

[0048] Preferably, the hair conditioning agent comprises any one or a combination of at least two of amodimethicone, polyquaternium-10, glycine, arginine or taurine.

[0049] Preferably, the humectant comprises glycerol and / or 1,2-hexanediol.

[0050] Preferably, the preservative includes any one of phenoxyethanol, ethylhexylglycerin or p-hydroxyacetophenone, or a combination of at least two thereof.

[0051] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0052] In a fourth aspect, the present invention provides a method for preparing the oil-controlling and anti-dandruff shampoo according to the third aspect, the preparation method comprising:

[0053] (1) heating the water, then adding thickener, chelating agent and surfactant and mixing them homogeneously;

[0054] (2) After cooling, add the composition with oil-controlling and anti-dandruff effects and continue to mix and homogenize, filter and let stand to obtain the oil-controlling and anti-dandruff shampoo.

[0055] Preferably, the temperature in step (1) is raised to 80-90°C, for example, 81°C, 83°C, 85°C, 87°C or 89°C.

[0056] Preferably, the temperature in step (2) is lowered to 50-60°C, for example, 51°C, 53°C, 55°C, 57°C or 59°C.

[0057] Preferably, the step (2) of mixing and homogenizing further comprises adding any one or a combination of at least two of a hair conditioner, a moisturizer, a pearlescent agent, a pH adjuster, a preservative or a fragrance.

[0058] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0059] Compared with the prior art, the present invention has the following beneficial effects:

[0060] (1) The six ingredients of the composition of the present invention, namely, sophorolipids, myristamidopropyl PG-dimethylammonium chloride phosphate, creatine, medicinal porphyra extract, hops extract and sodium chloride, are used in combination to have a synergistic effect. While having a cleansing effect on the hair, it can provide a healthy water-oil balance for the scalp, help maintain the integrity of the scalp barrier, and thus better reduce the sebum secretion of the scalp and reduce the formation of dandruff.

[0061] (2) The shampoo provided by the present invention not only has a cleaning effect, but also has a scalp conditioning effect, controls the oil content of the skin, has an antibacterial effect to a certain extent, and achieves the effects of oil control and dandruff removal. In addition, the selected ingredients are mild and less irritating to the human body, which can better meet people's pursuit of green life. DETAILED DESCRIPTION

[0062] In order to further explain the technical means and effects adopted by the present invention, the technical solution of the present invention is further described below in conjunction with the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.

[0063] The following materials and comparative examples are as follows:

[0064]

[0065] The rest of the raw materials can be used as long as they are purchased from regular dealers.

[0066] Example 1

[0067] The present embodiment provides a composition with oil-controlling and anti-dandruff effects, which comprises, by weight, 23 parts of sophorolipids, 17 parts of myristamidopropyl PG-dimethylammonium chloride phosphate, 10 parts of creatine, 0.1 parts of medicinal pore fungus extract, 0.1 parts of hops extract and 1.8 parts of sodium chloride.

[0068] Example 2

[0069] The present embodiment provides a composition with oil-controlling and anti-dandruff effects, which comprises, by weight, 25 parts of sophorolipids, 15 parts of myristamidopropyl PG-dimethylammonium chloride phosphate, 12 parts of creatine, 0.3 parts of medicinal pore fungus extract, 0.2 parts of hops extract and 1.5 parts of sodium chloride.

[0070] Example 3

[0071] The present embodiment provides a composition with oil-controlling and anti-dandruff effects, wherein the composition with oil-controlling and anti-dandruff effects comprises, by weight, 20 parts of sophorolipids, 20 parts of myristamidopropyl PG-dimethylammonium chloride phosphate, 9 parts of creatine, 0.2 parts of medicinal pore fungus extract, 0.2 parts of hops extract, and 1.6 parts of sodium chloride.

[0072] Example 4

[0073] The present embodiment provides a composition with oil-controlling and anti-dandruff effects, wherein the composition with oil-controlling and anti-dandruff effects comprises, by weight, 5 parts of sophorolipids, 25 parts of myristamidopropyl PG-dimethylammonium chloride phosphate, 20 parts of creatine, 2 parts of medicinal pore fungus extract, 2 parts of hop extract and 3 parts of sodium chloride.

[0074] Example 5

[0075] The present embodiment provides a composition with oil-controlling and anti-dandruff effects, which comprises, by weight, 35 parts of sophorolipids, 5 parts of myristamidopropyl PG-dimethylammonium chloride phosphate, 0.5 parts of creatine, 2 parts of medicinal pore fungus extract, 2 parts of hops extract and 0.5 parts of sodium chloride.

[0076] Comparative Example 1

[0077] This comparative example provides a composition with oil-controlling and anti-dandruff effects, which comprises, by weight, 23 parts of sophorolipids, 17 parts of myristamidopropyl PG-dimethylammonium chloride phosphate, 10 parts of creatine, 0.1 parts of medicinal pore fungus extract and 0.1 parts of hops extract.

[0078] Comparative Example 2

[0079] This comparative example provides a composition with oil-controlling and anti-dandruff effects, which comprises, by weight, 23 parts of sophorolipids, 17 parts of myristamidopropyl PG-dimethylammonium chloride phosphate, 10 parts of creatine, 0.1 parts of medicinal pore fungus extract, and 1.8 parts of sodium chloride.

[0080] Comparative Example 3

[0081] This comparative example provides a composition with oil-controlling and anti-dandruff effects, which comprises, by weight, 23 parts of sophorolipids, 17 parts of myristamidopropyl PG-dimethylammonium chloride phosphate, 10 parts of creatine, 0.1 parts of hop extract and 1.8 parts of sodium chloride.

[0082] Comparative Example 4

[0083] This comparative example provides a composition with oil-controlling and anti-dandruff effects, which comprises, by weight, 23 parts of sophorolipids, 17 parts of myristamidopropyl PG-dimethylammonium chloride phosphate, 0.1 parts of hop extract, 0.1 parts of medicinal pore fungus extract, and 1.8 parts of sodium chloride.

[0084] Comparative Example 5

[0085] This comparative example provides a composition with oil-controlling and anti-dandruff effects, which comprises, by weight, 23 parts of sophorolipids, 10 parts of creatine, 0.1 parts of hop extract, 0.1 parts of medicinal pore fungus extract, and 1.8 parts of sodium chloride.

[0086] Comparative Example 6

[0087] This comparative example provides a composition with oil-controlling and anti-dandruff effects, which comprises, by weight, 17 parts of myristamidopropyl PG-dimethylammonium chloride phosphate, 10 parts of creatine, 0.1 parts of hops extract, 0.1 parts of medicinal pore fungus extract, and 1.8 parts of sodium chloride.

[0088] Application Example 1

[0089] This embodiment provides an oil-controlling anti-dandruff shampoo. The components of the oil-controlling anti-dandruff shampoo are shown in the following table, and the amount of each component in the table is in parts:

[0090]

[0091]

[0092] The preparation method of the oil-controlling anti-dandruff shampoo is:

[0093] (1) Heat water to 85°C, then add thickener, chelating agent and surfactant and mix well;

[0094] (2) After cooling to 55° C., the oil-controlling and anti-dandruff shampoo, hair conditioner, fragrance, moisturizer and preservative are added and mixed until homogenized, filtered and allowed to stand to obtain the oil-controlling and anti-dandruff shampoo.

[0095] Application Example 2-5

[0096] This application example provides 4 kinds of oil-controlling and anti-dandruff shampoos. The difference between the oil-controlling and anti-dandruff shampoos and application example 1 is that the composition with oil-controlling and anti-dandruff effect in example 1 is replaced by the composition with oil-controlling and anti-dandruff effect in examples 2-5 in equal amounts, and the other components and amounts are the same as those in application example 1. The preparation method refers to application example 1.

[0097] Application Example 6

[0098] This application example provides an oil-control and anti-dandruff shampoo. The only difference between the oil-control and anti-dandruff shampoo and application example 1 is that the surfactant does not include a non-ionic surfactant, and the reduced amount is supplemented by an amphoteric surfactant. The other components and amounts are consistent with those in application example 1, and the preparation method refers to application example 1.

[0099] Application Example 7

[0100] This application example provides an oil-control and anti-dandruff shampoo. The only difference between the oil-control and anti-dandruff shampoo and application example 1 is that the surfactant does not include amphoteric surfactants, and the reduced amount is supplemented by the components of non-ionic surfactants in proportion to the number of parts. The other components and amounts are consistent with those in application example 1, and the preparation method refers to application example 1.

[0101] Application Example 8

[0102] This application example provides an oil-control and anti-dandruff shampoo. The only difference between the oil-control and anti-dandruff shampoo and application example 1 is that the surfactant does not include anionic surfactant, and the reduced amount is supplemented by the amino acid surfactant components in proportion to the number of parts. The other components and amounts are consistent with those in application example 1, and the preparation method refers to application example 1.

[0103] Application Example 9

[0104] This application example provides an oil-control and anti-dandruff shampoo. The only difference between the oil-control and anti-dandruff shampoo and application example 1 is that the surfactant does not include an amino acid surfactant, and the reduced amount is supplemented by the various components of the anionic surfactant in proportion to the number of parts. The other components and amounts are consistent with those in application example 1, and the preparation method refers to application example 1.

[0105] Comparative Application Examples 1-6

[0106] This comparative application example provides 6 kinds of oil-controlling and anti-dandruff shampoos. The difference between the oil-controlling and anti-dandruff shampoos and application example 1 is that the composition with oil-controlling and anti-dandruff effect of example 1 is replaced by the composition with oil-controlling and anti-dandruff effect of comparative examples 1-6 in equal amounts, and the other components and amounts are the same as those in application example 1. The preparation method refers to application example 1.

[0107] Comparative Application Example 7

[0108] This comparative application example provides an oil-controlling and anti-dandruff shampoo. The only difference between the oil-controlling and anti-dandruff shampoo and Application Example 1 is that the components do not include a composition with oil-controlling and anti-dandruff effects, and the reduced amount is supplemented by water. The other components and amounts are consistent with those in Application Example 1, and the preparation method refers to Application Example 1.

[0109] Test Example 1

[0110] 5α-Reductase Inhibition Test

[0111] Test samples: shampoo provided in Application Examples 1-9 and shampoo provided in Comparative Application Examples 1-7;

[0112] Experimental subjects: 8 male SD rat livers;

[0113] Experimental principle: Sebaceous gland hyperfunction is mainly related to the imbalance of sex hormone secretion. Sebaceous glands are the target organs of androgens. Testosterone increases the size of sebaceous glands and increases secretion. In particular, the overactive 5α-reductase, a catalyst for sebum synthesis in the human body, causes increased secretion of dihydrotestosterone, which causes the sebaceous glands to enlarge abnormally. Therefore, male skin is generally oilier than female skin, with larger pores, and there are also genetic factors. Mechanism of action of androgens: Most of the testosterone in the circulation is bound to sex hormone binding protein, and only 1-2% is free. This part enters the sebaceous gland cells and affects their function. Other male hormones in the circulation, dehydroepiandrosterone and androstenedione secreted by the adrenal glands, can also enter the sebaceous gland cells and be converted into testosterone to exert their effects. Testosterone entering the sebaceous glands is converted into 5α-dihydrotestosterone by 5α-reductase in the cells, and then binds to steroid cells in the cytoplasm, enters the cell nucleus, and binds to chromatin. By up-regulating and activating the sterol regulatory factor binding protein pathway to affect DNA transcription, it promotes sebaceous gland cell proliferation, differentiation and secretion;

[0114] Experimental steps: 16 identical 5α-reductase solutions were prepared using liver homogenates from 8 male SD rats and divided into 16 groups. One of the composition samples was added to each group. Through a series of reaction systems, the inhibition rate of the oil-control composition containing the oil-control composition on the 5α-reductase solution was detected. The higher the inhibition rate, the better the oil-control effect.

[0115] The specific test results are shown in Table 1 below:

[0116] Table 1

[0117] Test samples Inhibition rate of 5α-reductase solution / % Application Example 1 90.4 Application Example 2 89.9 Application Example 3 90.3 Application Example 4 78.6 Application Example 5 77.8 Application Example 6 67.4 Application Example 7 65.8 Application Example 8 61.3 Application Example 9 60.7 Comparative application example 1 65.8 Comparative Application Example 2 67.3 Comparative Application Example 3 66.9 Comparative Application Example 4 64.5 Comparative Application Example 5 63.7 Comparative Application Example 6 63.4 Comparative Application Example 7 44.9

[0118] It can be seen from the test results in Table 1 that, compared with Comparative Application Example 7, the shampoo prepared by adding the oil-controlling and anti-dandruff composition of the present invention has a significantly improved inhibition rate on 5α-reductase solution, which is above 75%.

[0119] It can be seen from Application Examples 4-5 that only when the amounts of sophorolipids, myristamidopropyl PG-dimethylammonium chloride phosphate, creatine, medicinal porphyrin extract, hop extract and sodium chloride are within the defined range of the present invention, the final shampoo can have a better effect of inhibiting 5α-reductase;

[0120] It can be seen from Application Examples 6-8 that the various surfactants used in the shampoo of the present invention have a synergistic effect, which can better improve the removal of oil from the scalp and promote the penetration effect of the composition, thereby improving the absorption and utilization of the active ingredients by the scalp;

[0121] The oil content reduction rate after use of comparative application examples 1-6 changes little, which shows that the sophorolipids, myristamidopropyl PG-dimethylammonium chloride phosphate, creatine, medicinal pore fungus extract, hops extract and sodium chloride in the composition with oil control and anti-dandruff effects involved in the present invention have a synergistic effect, which effectively solves the problem of excessive skin sebum secretion by inhibiting 5α-reductase, and further has the effect of regulating the balance of scalp sebum.

[0122] Test Example 2

[0123] (1) Test samples: shampoos provided in Application Examples 1-5 and shampoos provided in Comparative Application Examples 1-7;

[0124] (2) Test principle: Since Malassezia mainly grows in the stratum corneum of the skin, its increased growth rate destroys the microenvironment on the surface of the head skin, causing skin desquamation on the surface of the head skin, thus producing dandruff. Inhibiting the growth of Malassezia can inhibit the production of dandruff.

[0125] (3) Test method: Malassezia inhibition rate test:

[0126] ①Preparing a Malassezia furfur suspension;

[0127] ② Use PBS (0.03 mol / L phosphate buffer) to dilute the suspension of Malassezia (GDMCC2.181 as an example) appropriately. The concentration is: take 0.1 mL and drop it into 5.0 mL of the control sample PBS. The number of recovered bacteria is 1×10 4 -9×10 4 cfu / mL;

[0128] ③ Dilute the test sample with sterile water to the specified concentration;

[0129] ④Put 5.0mL of the test sample stock solution into a sterile test tube and keep it at 20℃ for 5 minutes;

[0130] ⑤ Pipette 0.1 mL of Malassezia liquid into the test tube containing 5.0 mL of sample, stir quickly, and start timing immediately;

[0131] ⑥ After 5 minutes of action, take 0.5 mL of the mixture of Malassezia and sample, add it to a test tube containing 4.5 mL of sterilized PBS, and mix thoroughly;

[0132] ⑦ After 10 minutes, take 1 mL of the sample solution and place it in a sterile plate. Inoculate two sterile plates with each sample solution, pour 15 mL of Leeming-Notman medium at 40℃-45℃, rotate the plate to make it fully uniform, turn the plate over after the Leeming-Notman medium solidifies, and culture at 28℃ for 7 days, then count the number of live bacteria.

[0133] ⑧ Replace the test sample with PBS and follow the above steps as the control sample;

[0134] ⑨ Repeat the experiment three times and calculate the average value. The calculation formula is as follows.

[0135]

[0136] Where I represents the average colony count of the control sample; II represents the average colony count of the test sample.

[0137] The results are shown in Table 2.

[0138] Table 2

[0139]

[0140] It can be seen from the test data in Table 2 that, from the comparison between comparative application example 7 and application examples 1-3, the shampoo prepared by adding the composition with oil control and anti-dandruff efficacy of the present invention has a significantly improved inhibition rate for Malassezia, and the inhibition rate is above 60%. It shows that the combination of the sophorolipids, myristamidopropyl PG-dimethylammonium chloride phosphate, creatine, medicinal lamina extract, hop extract and sodium chloride of the present invention has a synergistic effect, which can effectively inhibit the massive proliferation of Malassezia, thereby solving the problem of scalp desquamation.

[0141] Test Example 3 Consumer Sensory Effect Evaluation

[0142] 160 volunteers aged between 30 and 35 with scalp problems such as oily scalp and dandruff were selected as test subjects and randomly divided into 16 groups, 10 people in each group. Test method: The test subjects used the products of application examples 1-9 and comparative application examples 1-7 respectively, washed their hair once every two days, and used them continuously for 40 days. After use, the test subjects scored the use effect using a 5-point system: 4.5-5 points or more means very good, very satisfied; 3.5-4.5 points means good; 2.5-3.5 points means medium and acceptable; and below 2.5 points means bad, unacceptable. The score of each group is the average of 10 people, and the results are shown in Table 3.

[0143] Table 3

[0144]

[0145]

[0146] According to Table 3, the comprehensive score of the oil-controlling and anti-dandruff shampoo provided by the present invention is above 4.5 points on average, indicating that the shampoo has excellent anti-dandruff and oil-removing effects, rich and dense foam, and better scalp comfort after use.

[0147] In contrast, the scores of each item in Application Examples 1-6 have all decreased, indicating that the sophorolipids, myristamidopropyl PG-dimethylammonium chloride phosphate, creatine, medicinal pore fungus extract, hops extract and sodium chloride can be used in combination to better improve the oil control and anti-dandruff effect of the shampoo.

[0148] Test Example 4 Safety Evaluation:

[0149] The specific method is as follows: 40 females aged 18-35 years old with no history of allergies were selected, and each subject tried the samples prepared in Application Examples 1-9. After cleaning the back of the subject, the spot tester with the sample was applied to the selected position on the back with a non-irritating tape, and after pasting, it was lightly pressed with fingers to make it evenly attached to the skin for 48 hours. The subject kept the patch area dry within 48 hours, and avoided intense exercise, scratching the patch area, long-term sunlight exposure, etc. After 48 hours, the tester was removed and marked, and after 30 minutes, the indentation disappeared and the judgment was made under sufficient light.

[0150] The grading standards for adverse skin reactions are shown in Table 4:

[0151] Table 4

[0152]

[0153] The results are shown in Table 5:

[0154] Table 5

[0155]

[0156] It can be seen from the data in Table 5 that after removing the spot tester, no adverse reactions were observed on the skin of the volunteers, which indicates that the raw materials used in the shampoo of the present invention are safe and non-irritating, have no adverse reactions to the human body, and are highly safe.

[0157] The applicant declares that the present invention illustrates a composition with oil control and anti-dandruff effects and its application through the above embodiments, but the present invention is not limited to the above embodiments, that is, it does not mean that the present invention must rely on the above embodiments to be implemented. Those skilled in the art should understand that any improvement of the present invention, equivalent replacement of various raw materials of the product of the present invention, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

[0158] The preferred embodiments of the present invention are described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the technical concept of the present invention, a variety of simple modifications can be made to the technical solution of the present invention, and these simple modifications all belong to the protection scope of the present invention.

[0159] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not further describe various possible combinations.

Claims

1. A composition having oil control and anti-dandruff effects, characterized in that: The composition with oil-controlling and anti-dandruff effects comprises sophorolipids, myristamidopropyl PG-dimethylammonium chloride phosphate, creatine, medicinal porphyra extract, hop extract and sodium chloride.

2. The oil-control and anti-dandruff composition according to claim 1, characterized in that: The composition with oil-controlling and anti-dandruff effects comprises, by weight, 10-30 parts of sophorolipids, 1-20 parts of myristamidopropyl PG-dimethylammonium chloride phosphate, 1-15 parts of creatine, 0.1-1 parts of medicinal pore fungus extract, 0.1-1 parts of hop extract, and 0.1-2 parts of sodium chloride; Preferably, the composition with oil control and anti-dandruff effects comprises, by weight, 15-30 parts of sophorolipids, 5-20 parts of myristamidopropyl PG-dimethylammonium chloride phosphate, 5-15 parts of creatine, 0.1-0.8 parts of medicinal pore fungus extract, 0.1-0.8 parts of hops extract, and 0.5-2 parts of sodium chloride; Preferably, the composition with oil-controlling and anti-dandruff effects comprises, by weight, 15-25 parts of sophorolipids, 10-20 parts of myristamidopropyl PG-dimethylammonium chloride phosphate, 8-13 parts of creatine, 0.1-0.5 parts of medicinal pore fungus extract, 0.1-0.5 parts of hops extract and 1-2 parts of sodium chloride.

3. Use of the composition with oil-controlling and anti-dandruff effects as claimed in claim 1 or 2 in the preparation of toiletries.

4. The use according to claim 3, characterized in that: The toiletries are any one of shampoo, conditioner, hair mask, hair oil or hair spray; Preferably, the composition with oil-controlling and anti-dandruff effects is added in an amount of 1-10% in toiletries.

5. An oil-controlling anti-dandruff shampoo, characterized in that: The oil-controlling and anti-dandruff shampoo comprises the composition with oil-controlling and anti-dandruff efficacy according to claim 1 or 2, a surfactant, a thickener, a chelating agent and water.

6. The oil-controlling anti-dandruff shampoo according to claim 5, characterized in that: The oil-control and anti-dandruff shampoo comprises, by mass percentage, 1-20 parts of the composition with oil-control and anti-dandruff efficacy according to claim 1 or 2, 10-30 parts of a surfactant, 0.1-5 parts of a thickener, 0.1-2 parts of a chelating agent and 50-90 parts of water.

7. The oil-control anti-dandruff shampoo according to claim 5 or 6, characterized in that: The surfactant includes any one of a nonionic surfactant, an amphoteric surfactant, an amino acid surfactant or an anionic surfactant, or a combination of at least two thereof; Preferably, the surfactant includes a nonionic surfactant, an amphoteric surfactant, an amino acid surfactant and an anionic surfactant; Preferably, the nonionic surfactant includes any one of lauryl glucoside, cocamide methyl MEA, PPG-10 sorbitol, trideceth-3, trideceth-7, trideceth-9, or a combination of at least two thereof; Preferably, the amino acid surfactant includes any one or a combination of at least two of sodium cocoyl aminopropionate, sodium lauroyl sarcosinate, sodium lauroyl oat amino acids or sodium cocoyl apple amino acids; Preferably, the amino acid surfactant is a combination of sodium cocoyl aminopropionate, sodium lauroyl sarcosinate, sodium lauroyl oat amino acids and sodium cocoyl apple amino acids; Preferably, the anionic surfactant comprises sodium cocoyl isethionate and / or sodium lauryl glycol carboxylate; Preferably, the anionic surfactant is a combination of sodium cocoyl isethionate and sodium lauryl glycol carboxylate; Preferably, the amphoteric surfactant comprises cocamidopropyl betaine.

8. The oil-controlling anti-dandruff shampoo according to any one of claims 5 to 7, characterized in that: The thickener is any one of carbomer, xanthan gum, acrylic copolymer, PEG-120 methyl glucose dioleate or guar hydroxypropyltrimonium chloride, or a combination of at least two thereof; Preferably, the chelating agent comprises any one of EDTA-2Na, EDTA-4Na or tetrasodium glutamate diacetate or a combination of at least two thereof; Preferably, the oil-control anti-dandruff shampoo further comprises any one or a combination of at least two of a hair conditioner, a moisturizer, a pearlescent agent, a pH adjuster, a preservative or a fragrance; Preferably, the hair conditioning agent comprises any one or a combination of at least two of amodimethicone, polyquaternium-10, glycine, arginine or taurine; Preferably, the humectant comprises glycerol and / or 1,2-hexanediol; Preferably, the preservative includes any one of phenoxyethanol, ethylhexylglycerin or p-hydroxyacetophenone, or a combination of at least two thereof.

9. A method for preparing the oil-controlling anti-dandruff shampoo according to any one of claims 5 to 8, characterized in that: The preparation method comprises: (1) heating the water, then adding thickener, chelating agent and surfactant and mixing them homogeneously; (2) After cooling, add the composition with oil-controlling and anti-dandruff effects and continue to mix and homogenize, filter and let stand to obtain the oil-controlling and anti-dandruff shampoo.

10. The preparation method according to claim 9, characterized in that: Step (1) wherein the temperature is raised to 80-90° C. Preferably, the temperature in step (2) is lowered to 50-60°C; Preferably, the step (2) of mixing and homogenizing further comprises adding any one or a combination of at least two of a hair conditioner, a moisturizer, a pearlescent agent, a pH adjuster, a preservative or a fragrance.

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