Composition with soothing and moisturizing effects and application thereof

Abstract

The invention relates to a composition with soothing and moisturizing effects and application of the composition. The composition comprises a piper nigrum extract, an oat kernel extract, schizophyllan and tranexamic acid. According to the invention, when the kava pepper extract, the oat kernel extract, the schizophyllan and the tranexamic acid are creatively combined for use, synergistic interaction can be realized in the aspects of soothing skin, moisturizing and repairing skin barrier, and the soothing and moisturizing effects of the product are further improved. The composition with the soothing and moisturizing effects has the specific effects of increasing the water content of the skin, calming and soothing the skin, improving the facial redness condition and reducing the inflammatory response, is very suitable for skin care products, and is mild, free of irritation and good in stability.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics and relates to a composition with soothing and moisturizing effects and application thereof. Background Art

[0002] The human skin is an important barrier that prevents the loss of water, electrolytes and other substances in the body and blocks the invasion of harmful substances from the outside. The integrity of the skin barrier is essential for maintaining skin health. The skin barrier protects the body from the external environment, including the invasion of harmful microorganisms, chemicals, pollutants and physical damage (such as ultraviolet radiation). The skin barrier helps maintain the moisture of the skin and prevents excessive water loss, thereby keeping the skin soft and elastic. This function is mainly achieved through the stratum corneum of the epidermis. The lipids and natural moisturizing factors in the stratum corneum work together to form an effective moisturizing barrier. However, with age and the accumulation of sun damage, the skin barrier function may gradually weaken, leading to dry, flaky and dull skin.

[0003] Sensitive skin is a problematic skin caused by damaged skin barrier. The skin becomes dry and dehydrated due to changes in temperature, humidity and other environmental factors. At the same time, due to increased stress in life, improper cleaning methods or skin care products, aging, weakened sebum membrane protection, etc., the skin barrier function is damaged and sensitive to external stimuli. In this state, the skin's moisturizing function decreases, not only losing moisture and elasticity, but also the skin barrier protection function decreases, causing the skin to become rough. And because the skin barrier is too weak, sensitive skin is prone to burning, stinging, itching and tightness when it is stimulated by the outside world, and is also accompanied by symptoms such as erythema and capillary dilation.

[0004] At present, the first way to improve sensitive skin is to replenish water. The skin can only metabolize normally when it is well hydrated. Therefore, it is necessary to fully achieve the balance of water and oil in the skin through efficient moisturizing. At the same time, try to use some natural and mild ingredients to soothe the skin, so as to effectively improve the sensitivity of the skin. It is very meaningful to provide a mild cosmetic product that can efficiently moisturize and soothe the skin. Summary of the invention

[0005] In view of the deficiencies of the prior art, the object of the present invention is to provide a composition with soothing and moisturizing effects and its application, in particular to provide a composition with soothing and moisturizing effects and its application in cosmetics.

[0006] In order to achieve the purpose of the invention, the present invention adopts the following technical solutions:

[0007] In a first aspect, the present invention provides a composition with soothing and moisturizing effects, wherein the composition comprises kava extract, oat kernel extract, schizophyllan and tranexamic acid.

[0008] Among them, kava extract is a natural ingredient extracted from the leaves, stems and roots of kava, which can not only block nerve receptors but also further inhibit nerve transmission after the nerve receptors are activated, thereby inhibiting the expression of corresponding proteins to achieve the effect of soothing allergies. It also contains a variety of kava lactone ingredients and has excellent moisturizing effects. Oat kernel extract has the effects of whitening, moisturizing and skin care, can promote the production of natural collagen, improve skin elasticity, and has antioxidant capacity, which can effectively delay skin aging. Schizophyllan is a non-ionic water-soluble polysaccharide, and its mild and non-irritating polyhydroxylated The structure can moisturize and lock in moisture, promote the production of natural moisturizing factors, maintain the water content of the skin's stratum corneum, and can be recognized and bound by receptors on the body's immune cells, activate immune cells, and help regulate skin immunity; Tranexamic acid is a component with multiple functions, which can inhibit the functional disorder of epidermal cells in the dark spots of the skin and the production of melanin enhancing factor group phenomenon, effectively reduce the savings insurance of red acne marks, and can also inhibit the production of inflammatory factors by reducing the number of local mast cells, further inhibit local capillary hyperplasia, improve the color of red acne marks and reduce skin redness and swelling.

[0009] In the present invention, it is found that when the above four components are used in combination, they can synergistically enhance the effects of soothing the skin, moisturizing, and repairing the skin barrier, thereby further improving the soothing and moisturizing effects of the product.

[0010] Preferably, the composition comprises, by weight, 0.01-0.5 parts of kava extract, 0.01-0.5 parts of oat kernel extract, 0.5-3 parts of schizophyllan and 0.1-2 parts of tranexamic acid;

[0011] The above “0.01-0.5 parts” can be, for example, 0.01 parts, 0.02 parts, 0.05 parts, 0.08 parts, 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, etc.;

[0012] The above-mentioned “0.5-3 parts” can be, for example, 0.5 parts, 0.8 parts, 1 parts, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.2 parts, 2.5 parts, 2.8 parts, 3 parts, etc.;

[0013] The above-mentioned "0.1-2 parts" can be, for example, 0.1 parts, 0.2 parts, 0.5 parts, 0.8 parts, 1 parts, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, etc. Other specific point values ​​within the numerical range can be selected, and they will not be elaborated here one by one.

[0014] In the present invention, when the amount of the components of the composition with soothing and moisturizing effects is within the above specific range, the effect of soothing the skin and moisturizing and repairing the skin barrier is better.

[0015] Preferably, the Kava extract is prepared by a preparation method comprising the following steps:

[0016] The kava raw material is crushed, mixed with an alcohol aqueous solution, and subjected to a high-voltage pulse electric field extraction treatment. The treated liquid is filtered, the filtrate is collected, concentrated to remove alcohol, and freeze-dried to obtain the kava extract.

[0017] Preferably, the volume fraction of alcohol in the alcohol water is 40%-90%, for example, it can be 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, etc. Other specific point values ​​within this numerical range can be selected and will not be described one by one here; preferably, it is 60%-80%.

[0018] Preferably, the alcohol is selected from any one of ethanol, 1,3-butanediol, 1,3-propylene glycol, n-butanol, n-propanol or isopropanol, or a combination of at least two thereof.

[0019] Preferably, the field strength of the high-voltage pulse electric field is 2-8 kV / cm, for example, it can be 2 kV / cm, 2.5 kV / cm, 3 kV / cm, 3.5 kV / cm, 4 kV / cm, 4.5 kV / cm, 5 kV / cm, 5.5 kV / cm, 6 kV / cm, 6.5 kV / cm, 7 kV / cm, 7.5 kV / cm, 8 kV / cm, etc. Other specific point values ​​within this numerical range can be selected, and they will not be described one by one here.

[0020] Preferably, the number of high-voltage pulse electric field extraction treatments is 50-100 times, for example, it can be 50 times, 55 times, 60 times, 65 times, 70 times, 75 times, 80 times, 85 times, 90 times, 95 times, 100 times, etc. Other specific point values ​​within this numerical range can be selected, and they will not be described here one by one.

[0021] In the present invention, the kava pepper is extracted by using a high-voltage pulse electric field-assisted alcohol-water solution extraction method, and the obtained kava pepper extract has more significant effects in increasing skin moisture content and soothing and calming.

[0022] Preferably, the oat kernel extract is prepared by a preparation method comprising the following steps:

[0023] The oat kernel raw material is mixed with water and then subjected to ultra-high pressure treatment, the treated mixture is subjected to heating reflux extraction, and the extract is filtered and dried to obtain the oat kernel extract.

[0024] Preferably, the pressure of the ultra-high pressure treatment is 150-280 MPa, for example, it can be 150 MPa, 160 MPa, 175 MPa, 180 MPa, 200 MPa, 225 MPa, 240 MPa, 255 MPa, 260 MPa, 280 MPa, etc.; the holding time is 5-20 min, for example, it can be 5 min, 6 min, 8 min, 10 min, 12 min, 15 min, 18 min, 19 min, 20 min.

[0025] Compared with the traditional single heating reflux extraction method, the ultra-high pressure treatment of the oat kernel sample in the present invention has a better extract efficacy when the processed product is extracted, and the ultra-high pressure treatment has a better treatment effect when the above-mentioned specific process parameter range is adopted.

[0026] In a second aspect, the present invention provides a use of the composition with soothing and moisturizing effects according to the first aspect in cosmetics.

[0027] Preferably, the cosmetics include lotion, emulsion, cream, skin care essence or facial mask.

[0028] In a third aspect, the present invention provides a facial cream with soothing and moisturizing effects, wherein the facial cream comprises the composition with soothing and moisturizing effects described in the first aspect.

[0029] Preferably, the facial cream comprises, by mass fraction, 1%-15% of the composition with soothing and moisturizing effects described in the first aspect, 5%-10% of an emulsifier, 20%-35% of a moisturizer, 0.1%-3% of a thickener, 6%-15% of an emollient, and 40%-70% of water;

[0030] The above-mentioned “1%-15%” may be, for example, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, etc.;

[0031] The above-mentioned “5%-10%” may be, for example, 5%, 5.5%, 6%, 6.5%, 7%, 7.5%, 8%, 8.5%, 9%, 9.5%, 10%, etc.;

[0032] The above-mentioned “20%-35%” may be, for example, 20%, 22%, 24%, 25%, 26%, 28%, 30%, 32%, 34%, 35%, etc.;

[0033] The above-mentioned “0.1%-3%” may be, for example, 0.1%, 0.2%, 0.5%, 0.8%, 1%, 1.2%, 1.5%, 1.8%, 2%, 2.2%, 2.5%, 2.8%, 3%, etc.;

[0034] The above-mentioned “6%-15%” may be, for example, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, etc.;

[0035] The above-mentioned "40%-70%" can be, for example, 40%, 42%, 45%, 48%, 50%, 52%, 55%, 58%, 60%, 62%, 65%, 68%, 70%, etc. Other specific point values ​​within the numerical range can be selected, and they will not be elaborated here.

[0036] Preferably, the emulsifier includes any one of dimethicone, dimethicone / PEG-10 / 15 crosspolymer, PEG-10 dimethicone, hydroxypropyl cyclodextrin, polyethylene glycol or sodium cetearyl sulfate, or a combination of at least two thereof.

[0037] In the present invention, when polydimethylsiloxane, polydimethylsiloxane / PEG-10 / 15 cross-linked polymer and PEG-10 polydimethylsiloxane are used in combination as emulsifiers, it is found that the three can act synergistically to further improve the stability of the product and promote the relevant active ingredients to stably and efficiently exert their relevant functions.

[0038] Preferably, the moisturizing agent includes any one of polydimethylsiloxane, glycerin, trehalose, butylene glycol, propylene glycol, dipropylene glycol, betaine or sodium hyaluronate, or a combination of at least two thereof.

[0039] Preferably, the thickener comprises any one of sodium chloride, carbomer, xanthan gum, gelatin or carboxymethyl cellulose, or a combination of at least two thereof.

[0040] Preferably, the emollient includes any one or a combination of at least two of isononyl isononanoate, cyclopentasiloxane, pentylene glycol, caprylyl glycol, palmitole fruit oil or squalane.

[0041] In a fourth aspect, the present invention provides a method for preparing the facial cream according to the third aspect, the preparation method comprising uniformly mixing the composition with soothing and moisturizing effects according to the first aspect with other preparation raw materials to obtain the facial cream.

[0042] Preferably, the preparation method specifically comprises the following steps: mixing a moisturizer and an emollient with water at 60-70°C to obtain a mixed solution, cooling the mixed solution to 40-50°C and then uniformly mixing the mixed solution with an emulsifier, a thickener and the composition with soothing and moisturizing effects described in the first aspect to obtain the facial cream.

[0043] Compared with the prior art, the present invention has the following beneficial effects:

[0044] The present invention creatively combines the four components of kava extract, oat kernel extract, schizophyllan and tranexamic acid for synergistic effect in soothing the skin and moisturizing and repairing the skin barrier, further improving the soothing and moisturizing effect of the product. Specifically, it significantly increases the moisture content of the skin, improves redness, reduces inflammatory reactions, etc., and the composition is very suitable for skin care products, is mild and non-irritating, and has good stability. DETAILED DESCRIPTION

[0045] In order to further explain the technical means and effects adopted by the present invention, the technical solution of the present invention is further described below in conjunction with the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.

[0046] If no specific techniques or conditions are specified in the examples, the techniques or conditions described in the literature in the field or the product instructions are used. If no manufacturer is specified for the reagents or instruments used, they are all conventional products that can be purchased through regular channels.

[0047] The raw material information involved in the following examples and comparative examples is as follows:

[0048] Tranexamic acid comes from Guangzhou Nuoyan Biotechnology Co., Ltd.; schizophyllan comes from Guangzhou Nuoyan Biotechnology Co., Ltd.

[0049] Preparation Example 1

[0050] This preparation example provides a kava extract, and the preparation method thereof is as follows:

[0051] The kava raw material is ground and crushed, mixed with a 75% ethanol aqueous solution, with a material-liquid ratio of 1g:40mL, and subjected to a high-voltage pulse electric field extraction treatment with a field strength of 5kV / cm for 70 times. The treated liquid is filtered through 5 layers of gauze, the filtrate is collected, concentrated to remove alcohol, and freeze-dried to obtain the kava extract.

[0052] This preparation example also provides an oat kernel extract, and the preparation method thereof is as follows:

[0053] The oat kernel raw material is ground and crushed and mixed with water at a solid-liquid ratio of 1g:50mL. The mixture is treated with ultra-high pressure at a pressure of 220MPa and a holding time of 12min. The treated mixture is heated and refluxed for 10min. The extract is filtered through 5 layers of gauze, the filtrate is collected, and dried to obtain the oat kernel extract.

[0054] Preparation Example 2

[0055] This preparation example provides a kava extract, and the preparation method thereof is as follows:

[0056] The kava raw material is ground and crushed, and then mixed with a 60% ethanol and isopropanol mixed aqueous solution, wherein the volume ratio of ethanol to isopropanol is 1:1, and the material-liquid ratio is 1g:40mL, and a high-voltage pulse electric field extraction treatment is performed, the field strength is 3kV / cm, and the number of times is 85 times, the treated liquid is filtered through 5 layers of gauze, the filtrate is collected, concentrated to remove alcohol, and freeze-dried to obtain the kava extract.

[0057] This preparation example also provides an oat kernel extract, and the preparation method thereof is as follows:

[0058] The oat kernel raw material is ground and crushed and mixed with water at a solid-liquid ratio of 1g:40mL. The mixture is subjected to ultra-high pressure treatment at a pressure of 160MPa and a holding time of 18min. The treated mixture is heated and refluxed for 8min. The extract is filtered through 5 layers of gauze, the filtrate is collected, and dried to obtain the oat kernel extract.

[0059] Preparation Example 3

[0060] This preparation example provides a kava extract, and the preparation method thereof is as follows:

[0061] The kava raw material is ground and crushed, and then mixed with an 80% ethanol and 1,3-propylene glycol mixed aqueous solution, wherein the volume ratio of ethanol to 1,3-propylene glycol is 2:1, and the material-liquid ratio is 1g:60mL. A high-voltage pulse electric field extraction treatment is performed, the field strength is 7kV / cm, and the number of times is 60 times. The treated liquid is filtered through 5 layers of gauze, the filtrate is collected, concentrated to remove alcohol, and freeze-dried to obtain the kava extract.

[0062] This preparation example also provides an oat kernel extract, and the preparation method thereof is as follows:

[0063] The oat kernel raw material is ground and crushed and mixed with water at a solid-liquid ratio of 1g:60mL. The mixture is treated with ultra-high pressure at a pressure of 240MPa and a holding time of 8min. The treated mixture is heated and refluxed for 12min. The extract is filtered through 5 layers of gauze, the filtrate is collected, and dried to obtain the oat kernel extract.

[0064] Preparation Example 4

[0065] The present preparation example provides a kava extract, wherein the kava sample ground and crushed in Preparation Example 1 is mixed with a 75% ethanol aqueous solution at a solid-liquid ratio of 1 g:40 mL, and the mixture is heated in a water bath for 2 h of reflux extraction. The extract is filtered through 5 layers of gauze, the filtrate is collected, and freeze-dried to obtain the kava extract.

[0066] Preparation Example 5

[0067] This preparation example provides an oat kernel extract, which uses the oat kernel raw material in Preparation Example 1. The preparation method thereof is different from that in Preparation Example 1 only in that the pressure of the ultra-high pressure treatment is 120 MPa, the pressure holding time is 12 min, and subsequent treatment is performed to obtain the oat kernel extract.

[0068] Preparation Example 6

[0069] This preparation example provides an oat kernel extract, which uses the oat kernel raw material in Preparation Example 1. The preparation method thereof is different from that in Preparation Example 1 only in that the pressure of the ultra-high pressure treatment is 320 MPa, the pressure holding time is 12 min, and subsequent treatment is performed to obtain the oat kernel extract.

[0070] Example 1

[0071] The present embodiment provides a composition with soothing and moisturizing effects, which includes the following components in parts by mass: 0.15 parts of Kava extract (Preparation Example 1), 0.15 parts of oat kernel extract (Preparation Example 1), 1.5 parts of schizophyllan and 1 part of tranexamic acid.

[0072] Example 2

[0073] The present embodiment provides a composition with soothing and moisturizing effects, which includes the following components in parts by mass: 0.4 parts of Kava extract (Preparation Example 2), 0.05 parts of oat kernel extract (Preparation Example 2), 0.5 parts of schizophyllan and 1.85 parts of tranexamic acid.

[0074] Example 3

[0075] The present embodiment provides a composition with soothing and moisturizing effects, which includes the following components in parts by mass: 0.05 parts of Kava pepper extract (Preparation Example 3), 0.35 parts of oat kernel extract (Preparation Example 3), 2 parts of schizophyllan and 0.4 parts of tranexamic acid.

[0076] Example 4

[0077] This embodiment provides a composition with soothing and moisturizing effects, which is different from Example 1 only in that the Piper methysticum extract (Preparation Example 1) is replaced by an equal amount of the Piper methysticum extract prepared in Preparation Example 4.

[0078] Example 5

[0079] This embodiment provides a composition with soothing and moisturizing effects, which is different from Example 1 only in that the oat kernel extract (Preparation Example 1) is replaced by an equal amount of the kava extract prepared in Preparation Example 5.

[0080] Example 6

[0081] This embodiment provides a composition with soothing and moisturizing effects, which is different from Example 1 only in that the oat kernel extract (Preparation Example 1) is replaced by an equal amount of the kava extract prepared in Preparation Example 6.

[0082] Comparative Example 1

[0083] This comparative example provides a composition with soothing and moisturizing effects. The only difference from the remaining Example 1 is that the kava extract is not added, and the reduced amount thereof is proportionally distributed to the three components of oat kernel extract, schizophyllan and tranexamic acid.

[0084] Comparative Example 2

[0085] This comparative example provides a composition with soothing and moisturizing effects. The only difference from the remaining Example 1 is that oat kernel extract is not added, and the reduced amount thereof is proportionally distributed to the three components of kava extract, schizophyllan and tranexamic acid.

[0086] Comparative Example 3

[0087] This comparative example provides a composition with soothing and moisturizing effects. The only difference from the remaining Example 1 is that schizophyllan is not added, and its reduced amount is proportionally distributed to the three components of kava pepper extract, oat kernel extract and tranexamic acid.

[0088] Comparative Example 4

[0089] This comparative example provides a composition with soothing and moisturizing effects. The only difference from the remaining Example 1 is that tranexamic acid is not added, and the reduced amount thereof is proportionally distributed to the three components of kava extract, oat kernel extract and schizophyllan.

[0090] Application Example 1

[0091] This application example provides a facial cream with soothing and moisturizing effects, and its formula is as follows:

[0092]

[0093]

[0094] The preparation method is as follows: a moisturizer, an emollient and water are mixed, the mixture is stirred at a speed of 30 rpm and heated to 60° C., after complete dissolution, the mixture is cooled to 50° C. and then mixed with an emulsifier, a thickener and a soothing moisturizing composition, and the mixture is homogenized at 800 rpm for 60 seconds under a vacuum degree of -0.04 MPa, and then the mixture is stirred at 60 rpm and cooled to 38° C. to obtain the facial cream.

[0095] Application Example 2-6

[0096] This application example provides five kinds of facial creams, the formulas of which differ from those of application example 1 only in that the composition of example 1 is replaced with equal amounts of the compositions of examples 2-6, respectively, and the other ingredients and contents remain unchanged. The preparation method refers to that of application example 1.

[0097] Comparative Application Examples 1-4

[0098] This application example provides four types of facial creams, the formulas of which differ from those of application example 1 only in that the composition of example 1 is replaced with equal amounts of the compositions of comparative examples 1-4, respectively, and other ingredients and contents remain unchanged. The preparation method refers to that of application example 1.

[0099] Test Example 1

[0100] Matrix efficacy testing

[0101] This test example tests the moisturizing effects of the compositions in Examples 1-6 and Comparative Examples 1-4.

[0102] (1) First, the compositions in Examples 1-6 and Comparative Examples 1-4 were thoroughly mixed with deionized water to prepare test samples with a concentration of 1% for later use.

[0103] (2) A total of 66 healthy Chinese female subjects aged 24 to 40 years old who met the voluntary inclusion and exclusion criteria were selected and divided into 11 groups, with 6 subjects in each group.

[0104] (3) After cleansing and using toner in the morning and evening, the subjects took an appropriate amount of the complex solution and evenly applied it to the face. Massage gently until absorbed. Use twice a day, once in the morning and once in the evening, for 28 consecutive days.

[0105] (4) The relative moisture content of the skin surface was detected using a skin moisture content tester. The relative moisture content of the skin surface was recorded before using the sample, 14 days after using the sample, and 28 days after using the sample. The change rate of the relative moisture content of the skin surface relative to that before using the sample was calculated. At the same time, a group that only used lotion after cleansing was set as a blank control group. The cleansers and lotions used in each group were the same commercially available products. The results are shown in Table 1.

[0106] Table 1

[0107]

[0108] From the data in the table, we can see that:

[0109] (1) It can be seen from Examples 1 to 3 that the composition provided by the present invention has an excellent moisturizing effect and can significantly increase the moisture content of the skin after use.

[0110] (2) By comparing Example 1 with Examples 4-6, it can be seen that the kava extract and oat kernel extract prepared by the specific extraction process in the present invention have better moisturizing and soothing effects.

[0111] (3) By comparing Example 1 with Comparative Examples 1-4, it can be seen that when the compositions of Comparative Examples 1-4 do not contain any of the four components of Piper methysticum extract, oat kernel extract, schizophyllan and tranexamic acid, the moisturizing effect of the compositions is reduced compared with that of Example 1. It can be seen that the composition formed by the four components of Piper methysticum extract, oat kernel extract, schizophyllan and tranexamic acid in the present invention can effectively improve the moisturizing effect of the product.

[0112] Test Example 2

[0113] Facial Cream Efficacy Test-Moisturizing and Repairing

[0114] (1) 60 healthy Chinese female subjects with dry, red, fragile, sensitive and rough faces were selected, with 6 subjects in each group, ranging in age from 35 to 60 years old, with an average age of 46.3±5.6 years old. After arriving at the laboratory, the subjects cleaned their faces with facial cleanser and used lotion, sat still for 30 minutes, and tested their skin. After applying the cream product and massaging until absorbed, the skin was tested again. The subjects used the product every morning and evening, and a follow-up visit was conducted after 14 days. During the follow-up visit, the subjects cleaned their faces with facial cleanser and used lotion, sat still for 30 minutes, and tested their skin. The changes before and after the skin were statistically analyzed to obtain the change rate.

[0115] (2) Test items include:

[0116] Skin moisture tester Comeometer CM825 tests the moisture content of the skin stratum corneum;

[0117] Cutometer MPA580 is a skin elasticity tester that tests skin elasticity and firmness;

[0118] Skin-Colorimeter CL 400 tests the skin a* value;

[0119] Skin melanin and hemoglobin tester Mexamter MX18 tests skin hemoglobin.

[0120] (3) The test products are the cream products prepared in Application Examples 1-6 and Comparative Application Examples 1-4; the test environment is at a temperature of 20° C. and a humidity of 50%, which meets the requirements of the scheme design; the improvement after using the product (%) = (data after use - data before use) / data before use × 100%; the results are shown in Table 2:

[0121] Table 2

[0122]

[0123] From the data in the table we can see that:

[0124] (1) It can be seen from Application Examples 1 to 3 that the facial cream product prepared by the present invention has significant moisturizing and soothing repairing effects, among which Application Example 1 has the best comprehensive effect.

[0125] (2) By comparing Application Example 1 with Application Examples 4-6, it can be seen that the kava extract and oat kernel extract prepared by the specific extraction method in the present invention have better moisturizing and soothing effects.

[0126] (3) By comparing Application Example 1 with Comparative Application Examples 1-4, it can be seen that the present invention uses a compound of four components, namely, kava extract, oat kernel extract, schizophyllan and tranexamic acid, to make the product have good moisturizing, water-locking, soothing and repairing effects. When the soothing and moisturizing compositions used in Comparative Application Examples 1-4 do not contain any of the above four components, the moisturizing and soothing effects of the facial cream products prepared from the formed compositions are all lower than those in Application Example 1, indicating that the above four components have a synergistic promotion effect in moisturizing and soothing effects that is difficult for technicians in the field to predict.

[0127] Test Example 3

[0128] Facial Cream Efficacy Test-Anti-Inflammatory

[0129] Test method: RAW264.7 mouse macrophages in logarithmic growth phase with good morphology were selected and inoculated in DMEM culture medium containing 10% FBS fetal bovine serum and incubated for 24 hours. 5 The cells were seeded at a density of cells / well in a 24-well plate and incubated in an incubator at 37°C and 5% CO2 for 2 hours. The cells were stimulated with 1 μg / mL lipopolysaccharide for 24 hours to establish a cellular inflammation model.

[0130] 0.5% of the cream products prepared in Application Examples 1-6 and Comparative Application Examples 1-4 were added to each group of cells, wherein the negative control group was a DMEM culture medium with an equal amount of 10% FBS fetal bovine serum added, and the positive control group was added with 0.01% dexamethasone. After incubation at 37°C for 24 hours, the cell supernatant was taken and tested according to the instructions of the ELISA kit, and the contents of TNF-1β, IL-6 and PGE2 inflammatory factors in the collected cell supernatant were detected respectively, and the experimental results were analyzed by data processing software, and the results are shown in Table 3.

[0131] Table 3

[0132]

[0133]

[0134] TNF-1β, IL-6 and PGE2 are important pro-inflammatory mediators that mediate the occurrence of a variety of inflammatory reactions. By reducing their content, the inflammatory response can be inhibited, thereby achieving an anti-inflammatory effect. The data in the table show that:

[0135] (1) It can be seen from Application Examples 1 to 3 that the facial cream product prepared from the composition of the four components provided by the present invention, including kava extract, oat kernel extract, schizophyllan and tranexamic acid, has a significant inhibitory effect on the three pro-inflammatory mediators when used in trace amounts, proving that it has excellent anti-inflammatory efficacy.

[0136] (2) By comparing Application Example 1 with Application Examples 4-6, it can be seen that the specific extraction method used in the present invention can promote the efficient extraction of relevant active ingredients, and the kava extract and oat kernel extract prepared by the specific extraction method are added to the product to obtain a better anti-inflammatory effect.

[0137] (3) By comparing Application Example 1 with Comparative Application Examples 1-4, it can be seen that the present invention uses a compound of four components, namely, kava extract, oat kernel extract, schizophyllan and tranexamic acid, to make the product have a good moisturizing, water-locking, soothing and repairing effect. When the soothing and moisturizing compositions used in Comparative Application Examples 1-4 do not contain any of the above four components, the anti-inflammatory effect of the facial cream products prepared from the formed compositions is lower than that of Application Example 1, indicating that the above four components have a synergistic promotion effect on the relevant effects that is difficult for technicians in the field to predict.

[0138] Test Example 4

[0139] Safety Testing

[0140] This test example tests the safety of the facial cream products prepared according to Examples 1-6.

[0141] According to the inclusion criteria, 30 women and 30 men were selected to participate in the test and randomly divided into 6 groups (5 men and 5 women in each group) to receive the trial. Use a syringe to take 0.025mL of sample and place it in the chamber of the spot test tape. The spot tester with sample is applied to the skin of the curved side of the forearm of the subject with medical tape for 24 hours. 30 minutes after removing the test spot tester, observe the skin reaction after the indentation disappears. For those with negative results, observe again 24 hours and 48 hours after the test, and record the skin reaction results.

[0142] The results show that the products prepared in Application Examples 1-6 showed negative reactions 24h and 48h after the test, and there was no irritation or erythema. It can be seen that the cream product prepared by the composition with soothing and moisturizing effects provided by the present invention has no irritation to the skin and no positive reaction, which proves that the product is highly safe, less irritating, and milder.

[0143] In summary, the present invention creatively combines the four components of kava extract, oat kernel extract, schizophyllan and tranexamic acid, and finds that these four components can interact with each other and have a synergistic promoting effect on moisturizing and soothing and repairing effects that is difficult for technicians in this field to predict, and can further improve the soothing and moisturizing effect of the product.

[0144] The applicant declares that the present invention illustrates the technical solution of the present invention through the above-mentioned embodiments, but the present invention is not limited to the above-mentioned embodiments, that is, it does not mean that the present invention must rely on the above-mentioned embodiments to be implemented. Those skilled in the art should understand that any improvement of the present invention, equivalent replacement of various raw materials of the product of the present invention, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

[0145] The preferred embodiments of the present invention are described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the technical concept of the present invention, a variety of simple modifications can be made to the technical solution of the present invention, and these simple modifications all belong to the protection scope of the present invention.

[0146] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not further describe various possible combinations.

Claims

1. A composition with soothing and moisturizing effects, characterized in that: The composition includes kava extract, oat kernel extract, schizophyllan and tranexamic acid.

2. The composition with soothing and moisturizing effects according to claim 1, characterized in that: The composition comprises, by weight, 0.01-0.5 parts of kava extract, 0.01-0.5 parts of oat kernel extract, 0.5-3 parts of schizophyllan and 0.1-2 parts of tranexamic acid.

3. The composition with soothing and moisturizing effects according to claim 1 or 2, characterized in that: The kava extract is prepared by a preparation method comprising the following steps: The kava raw material is crushed, mixed with an alcohol aqueous solution, and subjected to a high-voltage pulse electric field extraction treatment. The treated liquid is filtered, the filtrate is collected, concentrated to remove alcohol, and freeze-dried to obtain the kava extract.

4. The composition with soothing and moisturizing effects according to claim 3, characterized in that: The volume fraction of alcohol in the alcohol water is 40%-90%; Preferably, the alcohol is selected from any one or a combination of at least two of ethanol, 1,3-butanediol, 1,3-propylene glycol, n-butanol, n-propanol or isopropanol; Preferably, the field strength of the high voltage pulse electric field is 2-8 kV / cm; Preferably, the high voltage pulse electric field extraction treatment is performed 50-100 times.

5. The composition with soothing and moisturizing effects according to claim 1 or 2, characterized in that: The oat kernel extract is prepared by a preparation method comprising the following steps: The oat kernel raw material is mixed with water and then subjected to ultra-high pressure treatment, the treated mixture is subjected to heating reflux extraction, and the extract is filtered and dried to obtain the oat kernel extract.

6. The composition with soothing and moisturizing effects according to claim 5, characterized in that: The pressure of the ultra-high pressure treatment is 150-280 MPa, and the pressure holding time is 5-20 min.

7. Use of the composition with soothing and moisturizing effects according to any one of claims 1 to 6 in cosmetics; Preferably, the cosmetics include lotion, emulsion, cream, skin care essence or facial mask.

8. A facial cream with soothing and moisturizing effects, characterized in that: The facial cream comprises the composition with soothing and moisturizing effects according to any one of claims 1 to 6.

9. The facial cream according to claim 8, characterized in that The facial cream comprises, by mass fraction, 1%-15% of the composition with soothing and moisturizing effects according to any one of claims 1 to 6, 5%-10% of an emulsifier, 20%-35% of a moisturizer, 0.1%-3% of a thickener, 6%-15% of an emollient, and 40%-70% of water.

10. The facial cream according to claim 8 or 9, characterized in that The emulsifier includes any one of dimethicone, dimethicone / PEG-10 / 15 crosspolymer, PEG-10 dimethicone, hydroxypropyl cyclodextrin, polyethylene glycol or sodium cetearyl sulfate or a combination of at least two thereof; Preferably, the moisturizing agent includes any one of polydimethylsiloxane, glycerin, trehalose, butylene glycol, propylene glycol, dipropylene glycol, betaine or sodium hyaluronate, or a combination of at least two thereof; Preferably, the thickener comprises any one or a combination of at least two of sodium chloride, carbomer, xanthan gum, gelatin or carboxymethyl cellulose; Preferably, the emollient comprises any one of isononyl isononanoate, cyclopentasiloxane, pentylene glycol, caprylyl glycol, palmitole fruit oil or squalane, or a combination of at least two thereof.

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