Cosmetic composition containing deoxyarbutin and preparation method thereof

Abstract

The invention belongs to the technical field of cosmetics, and particularly relates to a cosmetic composition containing deoxyarbutin and a preparation method of the cosmetic composition. The cosmetic composition is prepared from the following raw materials in percentage by weight: 2%-5% of deoxyarbutin, 9%-20% of polyol, 0.7%-1.5% of a bacteriostatic agent, 50%-75% of nanocellulose hydrogel, 0-5% of a humectant, 0-1% of a thickening agent and the balance of deionized water. According to the invention, oxygenolysis of deoxyarbutin in water is prevented, the texture and the smearing feeling of cosmetics are remarkably improved, the cosmetics can be better attached to skin, the product action time is prolonged, and the action effect and the use comfort feeling are improved.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics, and in particular relates to a cosmetic composition containing deoxyarbutin and a preparation method thereof. Background Art

[0002] Deoxyarbutin is a new and highly effective tyrosinase inhibitor, which can be used as a whitening functional ingredient in cosmetics. Under the condition of ensuring 95% cell survival, deoxyarbutin has the best effect in inhibiting tyrosinase activity, which is 10 times that of hydroquinone, 38.5 times that of α-arbutin, and 350 times that of β-arbutin, and the safe concentration is more than 4 times that of hydroquinone. Deoxyarbutin is easily decomposed by light and rapidly degraded in water, which greatly hinders its large-scale application in cosmetics. Therefore, improving the stability of deoxyarbutin is of great significance to its application and development.

[0003] As factors such as environmental changes and aging cause the skin to lose moisture and become rough, cosmetics with high water content can increase the water content of the stratum corneum, keeping the skin hydrated, and making the skin appear smooth, soft and elastic. In addition, by increasing the skin's acceptance of nutrients and synergizing with products with different functionalities, it provides moisture, protection and nutrition to the skin, playing an important role in the skin care process.

[0004] The high specific surface area of ​​nanocellulose can quickly absorb water molecules. Its surface contains abundant hydrophilic groups such as hydroxyl groups, which can form hydrogen bonds with water molecules and attract a large number of water molecules more quickly, allowing nanocellulose to quickly absorb a large amount of water and form a stable bond. Nanocellulose can play a variety of roles in cosmetics. It can be used as a cosmetic modifier, moisturizer, nanofiller, skin feel regulator and film. It is a nanomaterial extracted from natural cellulose resources. It has the characteristics of biodegradability, biocompatibility, non-toxicity, etc., and has broad application prospects.

[0005] Chih-Chien Lin et al. disclosed a study on the stability of deoxyarbutin in an anhydrous emulsion system in Int. J. Mol. Sci. 2011, 12, 5946-5954, and used deoxyarbutin in an anhydrous emulsification system to avoid contact between deoxyarbutin and water, thereby preventing deoxyarbutin from decomposing in water. However, the document requires the addition of deoxyarbutin to the anhydrous emulsification system, and still does not solve the problem of rapid degradation of deoxyarbutin in water. Summary of the invention

[0006] The invention provides a cosmetic composition containing deoxyarbutin and a preparation method thereof.

[0007] To achieve the above object, the present invention adopts the following technical solution: A cosmetic composition containing deoxyarbutin is prepared from the following raw materials: by weight, 2% to 5% of deoxyarbutin, 9% to 20% of polyol, 0.7% to 1.5% of antibacterial agent, 50% to 75% of nanocellulose hydrogel, 0% to 5% of moisturizing agent, 0% to 1% of thickening agent, and the balance is deionized water.

[0008] Preferably, the weight ratio of the polyol to deoxyarbutin is 3-9:1.

[0009] Preferably, the weight ratio of the nanocellulose hydrogel to deoxyarbutin is 15-25:1.

[0010] Preferably, the mass concentration of dry cellulose in the nanocellulose hydrogel is 2-5 wt%.

[0011] Preferably, the diameter of the dry cellulose in the nanocellulose hydrogel is 3-5 nm, and the aspect ratio is 180-300.

[0012] Preferably, the polyol is one or more of glycerol, butylene glycol, propylene glycol, sorbitol and polyethylene glycol.

[0013] Preferably, the antibacterial agent is one or more of ethylhexylglycerin, phenoxyethanol, p-hydroxyacetophenone, 1,2-hexanediol, p-hydroxybenzoic acid esters and salicylic acid.

[0014] Preferably, the moisturizer is one or more of niacinamide, sodium hyaluronate and vitamin E.

[0015] Preferably, the thickener is one or more of carbomer, xanthan gum, starch, acrylic acid and ethyl acrylate.

[0016] The preparation method of the above-mentioned cosmetic composition containing deoxyarbutin comprises the following steps: (1) Mix deoxyarbutin and polyol, and stir evenly at room temperature to obtain a mixed solution A; (2) Evenly mix the moisturizer, thickener and deionized water to obtain a mixed solution B; (3) Add the mixed solution B and the mixed solution A to the nanocellulose hydrogel, add the antibacterial agent, stir evenly, and perform high-pressure homogenization to obtain the nanocellulose hydrogel.

[0017] The positive beneficial effects of the present invention are: 1. The present invention provides a deoxyarbutin cosmetic with water as the main component, wherein the nanocellulose hydrogel contains nanocellulose with a large aspect ratio, which has a high specific surface area and is rich in hydroxyl groups to form hydrogen bonds with water, forming a more stable network structure in the cosmetic formula, which helps to stabilize various active ingredients in the product and prevent the separation or sedimentation of the ingredients, thereby preventing deoxyarbutin from being oxidized and decomposed in water. The large surface area of ​​the nanocellulose with a large aspect ratio increases the contact surface between the mesh and the skin, which helps to effectively transport the active agent to deeper parts of the skin, and the nanocellulose with a large aspect ratio has high viscosity and shear thinning properties, and the reduced shear viscosity helps the deoxyarbutin to be mixed and stirred, and the high viscosity property is restored after mixing, thereby improving the stability of the cosmetic ingredients. Nanocellulose can absorb a large amount of water molecules and release them. The cosmetics of the present invention have a high water content, which keeps the skin moisturized, significantly improves the texture and application feel of the cosmetics, facilitates better adhesion to the skin, prolongs the product action time, enhances the effect and the comfort of use, and makes the skin feel more refreshing, moisturized and non-greasy. In addition, the nanocellulose contains rich polyphenols, which can inhibit the generation of free radicals and prevent skin aging, and is suitable for all skin types.

[0018] The present invention utilizes the hydroxyl structure of nanocellulose and the polyhydroxyl structure of polyol to form a hydrogen bond network and the nanocellulose to act as a surfactant, thereby encapsulating deoxyarbutin therein and reducing its contact with external factors; the nanocellulose hydrogel and the certain viscosity of the polyol provide a stable physical barrier for deoxyarbutin, thereby reducing the oxidative decomposition of deoxyarbutin in water and playing a protective role. The weight ratio of the polyol to deoxyarbutin is 3-9:1, and the weight ratio of the nanocellulose hydrogel to deoxyarbutin is 15-25:1. The present invention effectively slows down the oxidative decomposition of deoxyarbutin in solvent water, innovatively applies deoxyarbutin directly to high-water content system cosmetics, and solves the application limitations of deoxyarbutin in oil-free, low-oil or high-water content systems. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 The comparison diagram of the cosmetic composition Example 1 (left) and Comparative Example 1 (right) at different temperatures; Figure 2 The figures are comparative diagrams of the cosmetic composition Example 1 (left) and Comparative Example 2 (right) of the present invention after being placed for different number of days. DETAILED DESCRIPTION

[0020] The present invention is further described below in conjunction with some specific embodiments.

[0021] The preparation method of the nanocellulose hydrogel of the present invention is as follows: The wood pulp cellulose pulp was placed in an electron beam irradiation device for irradiation, with an irradiation voltage of 150 KeV and a dose of 120 kGy, and then mixed with sodium hydroxide and ethanol in a mass ratio of 10:1:9, placed in a kneader, and reacted at 70°C for 3 hours. After being taken out and washed with water, dry cellulose was obtained. The diameter of the dry cellulose was 3-5 nm, and the aspect ratio was 180-300. The dry cellulose was configured into a cellulose aqueous dispersion with a mass concentration of 2%, and after stirring and homogenization, a nanocellulose hydrogel was obtained.

[0022] Example 1 A cosmetic composition containing deoxyarbutin is prepared from the following raw materials: by weight, 3% deoxyarbutin, 15% 1,3-butylene glycol, 0.8% of a blend of ethylhexylglycerin and phenoxyethanol (the weight ratio of the two is 1:1), 75% nanocellulose hydrogel, 2% niacinamide, and the remainder is deionized water.

[0023] The preparation method of the above-mentioned cosmetic composition containing nanohydrogel of deoxyarbutin comprises the following steps: (1) Mix deoxyarbutin and 1,3-butanediol, and stir evenly at room temperature to obtain a mixed solution A; (2) Mixing nicotinamide and deionized water uniformly to obtain a mixed solution B; (3) Add the mixed solution B and the mixed solution A to the nanocellulose hydrogel, add the blend of ethylhexylglycerin and phenoxyethanol, and homogenize under high pressure to obtain the product.

[0024] Example 2 A cosmetic composition containing deoxyarbutin is prepared from the following raw materials: by weight, 2.5% of deoxyarbutin, 20% of 1,3-butylene glycol, 0.8% of a blend of ethylhexylglycerin and phenoxyethanol (the weight ratio of the two is 1:1), 60% of nanocellulose hydrogel, 2% of niacinamide, 0.1% of carbomer, and the remainder is deionized water.

[0025] The preparation method of the above-mentioned cosmetic composition containing nanohydrogel of deoxyarbutin comprises the following steps: (1) Mix deoxyarbutin and 1,3-butanediol, and stir evenly at room temperature to obtain a mixed solution A; (2) Evenly mixing niacinamide, carbomer and deionized water to obtain a mixed solution B; (3) Add the mixed solution B and the mixed solution A to the nanocellulose hydrogel, add the blend of ethylhexylglycerin and phenoxyethanol, and homogenize under high pressure to obtain the product.

[0026] Example 3 A cosmetic composition containing deoxyarbutin is prepared from the following raw materials: by weight percentage, 2% deoxyarbutin, 12% 1,3-butylene glycol, 0.8% of a blend of ethylhexylglycerin and phenoxyethanol (the weight ratio of the two is 1:1), 50% nanocellulose hydrogel, 2% niacinamide, 0.2% carbomer, and the remainder is deionized water.

[0027] The preparation method of the above-mentioned cosmetic composition containing nanohydrogel of deoxyarbutin comprises the following steps: (1) Mix deoxyarbutin and 1,3-butanediol, and stir evenly at room temperature to obtain a mixed solution A; (2) Evenly mixing niacinamide, carbomer and deionized water to obtain a mixed solution B; (3) Add the mixed solution B and the mixed solution A to the nanocellulose hydrogel, add the blend of ethylhexylglycerin and phenoxyethanol, and homogenize under high pressure to obtain the product.

[0028] Example 4 A cosmetic composition containing deoxyarbutin is prepared from the following raw materials: by weight percentage, 5% deoxyarbutin, 8% 1,3-butylene glycol, 7% polyethylene glycol 400, 0.8% of a blend of ethylhexylglycerin and phenoxyethanol (the weight ratio of the two is 1:1), 75% nanocellulose hydrogel, 2% sodium hyaluronate, and the remainder is deionized water.

[0029] The preparation method of the above-mentioned cosmetic composition containing nanohydrogel of deoxyarbutin comprises the following steps: (1) Mix deoxyarbutin, 1,3-butanediol and polyethylene glycol 400, and stir evenly at room temperature to obtain a mixed solution A; (2) Mixing sodium hyaluronate and deionized water uniformly to obtain a mixed solution B; (3) Add the mixed solution B and the mixed solution A to the nanocellulose hydrogel, add the blend of ethylhexylglycerin and phenoxyethanol, and homogenize under high pressure to obtain the product.

[0030] Example 5 A cosmetic composition containing deoxyarbutin is prepared from the following raw materials: by weight percentage, 3% deoxyarbutin, 10% 1,3-butylene glycol, 10% polyethylene glycol 400, 1.5% ethylhexylglycerol and phenoxyethanol blend (the weight ratio of the two is 1:1), 60% nanocellulose hydrogel, 2% vitamin E, 0.1% carbomer, and the rest is deionized water.

[0031] The preparation method of the above-mentioned cosmetic composition containing nanohydrogel of deoxyarbutin comprises the following steps: (1) Mix deoxyarbutin, 1,3-butanediol and polyethylene glycol 400, and stir evenly at room temperature to obtain a mixed solution A; (2) Mixing vitamin E, carbomer and deionized water uniformly to obtain a mixed solution B; (3) Add the mixed solution B and the mixed solution A to the nanocellulose hydrogel, add the blend of ethylhexylglycerin and phenoxyethanol, and homogenize under high pressure to obtain the product.

[0032] Example 6 A cosmetic composition containing deoxyarbutin is prepared from the following raw materials: by weight percentage, 2% deoxyarbutin, 10% 1,3-butylene glycol, 8% polyethylene glycol 400, 0.7% ethylhexylglycerin and phenoxyethanol blend (the weight ratio of the two is 1:1), 50% nanocellulose hydrogel, 2% sodium hyaluronate, 0.2% xanthan gum, and the rest is deionized water.

[0033] The preparation method of the above-mentioned cosmetic composition containing nanohydrogel of deoxyarbutin comprises the following steps: (1) Mix deoxyarbutin, 1,3-butanediol and polyethylene glycol 400, and stir evenly at room temperature to obtain a mixed solution A; (2) Evenly mix sodium hyaluronate, xanthan gum and deionized water to obtain a mixed solution B; (3) Add the mixed solution B and the mixed solution A to the nanocellulose hydrogel, add the blend of ethylhexylglycerin and phenoxyethanol, and homogenize under high pressure to obtain the product.

[0034] Example 7 A cosmetic composition containing deoxyarbutin is prepared from the following raw materials: by weight, 3% deoxyarbutin, 9% 1,3-butylene glycol, 0.8% a blend of ethylhexylglycerin and phenoxyethanol (the weight ratio of the two is 1:1), 60% nanocellulose hydrogel, 2% niacinamide, and the remainder is deionized water.

[0035] The preparation method of the above-mentioned cosmetic composition containing nanohydrogel of deoxyarbutin comprises the following steps: (1) Mix deoxyarbutin and 1,3-butanediol, and stir evenly at room temperature to obtain a mixed solution A; (2) Mixing nicotinamide and deionized water uniformly to obtain a mixed solution B; (3) Add the mixed solution B and the mixed solution A to the nanocellulose hydrogel, add the blend of ethylhexylglycerin and phenoxyethanol, and homogenize under high pressure to obtain the product.

[0036] Example 8 A cosmetic composition containing deoxyarbutin is prepared from the following raw materials: by weight, 2.5% of deoxyarbutin, 10% of 1,3-butylene glycol, 10% of glycerol, 1% of a blend of ethylhexylglycerol and phenoxyethanol (the weight ratio of the two is 1:1), 60% of nanocellulose hydrogel, 2% of niacinamide, 0.1% of xanthan gum, and the remainder is deionized water.

[0037] The preparation method of the above-mentioned cosmetic composition containing nanohydrogel of deoxyarbutin comprises the following steps: (1) Mix deoxyarbutin, 1,3-butanediol and glycerol, and stir evenly at room temperature to obtain a mixed solution A; (2) Evenly mixing niacinamide, xanthan gum and deionized water to obtain a mixed solution B; (3) Add the mixed solution B and the mixed solution A to the nanocellulose hydrogel, add the blend of ethylhexylglycerin and phenoxyethanol, and homogenize under high pressure to obtain the product.

[0038] Example 9 A cosmetic composition containing deoxyarbutin is prepared from the following raw materials: by weight percentage, 2.5% of deoxyarbutin, 10% of 1,3-butylene glycol, 0.7% of a blend of ethylhexylglycerin and phenoxyethanol (the weight ratio of the two is 1:1), 55% of nanocellulose hydrogel, 2% of niacinamide, 0.2% of carbomer, and the remainder is deionized water.

[0039] The preparation method of the above-mentioned cosmetic composition containing nanohydrogel of deoxyarbutin comprises the following steps: (1) Mix deoxyarbutin and 1,3-butanediol, and stir evenly at room temperature to obtain a mixed solution A; (2) Evenly mixing niacinamide, carbomer and deionized water to obtain a mixed solution B; (3) Add the mixed solution B and the mixed solution A to the nanocellulose hydrogel, add the blend of ethylhexylglycerin and phenoxyethanol, and homogenize under high pressure to obtain the product.

[0040] Comparative Example 1 A cosmetic composition containing deoxyarbutin is prepared from the following raw materials: by weight percentage, 3% deoxyarbutin, 0.8% of a blend of ethylhexylglycerin and phenoxyethanol (the weight ratio of the two is 1:1), 75% nanocellulose hydrogel, 2% niacinamide, and the remainder is deionized water.

[0041] Comparative Example 2 A cosmetic composition containing deoxyarbutin is prepared from the following raw materials: by weight percentage, 3% deoxyarbutin, 15% 1,3-butylene glycol, 0.8% of a blend of ethylhexylglycerin and phenoxyethanol (the weight ratio of the two is 1:1), 2% niacinamide, and the rest is deionized water.

[0042] The stability test was performed on Example 1 of the present invention and Comparative Examples 1 and 2: Compared with Example 1 in which nanocellulose hydrogel and 1,3-butanediol were used in combination, Comparative Example 1 was used without using 1,3-butanediol, and stability tests were performed at low temperature of 4°C, room temperature, and high temperature of 50°C. Figure 1 Example 1 (left) and Comparative Example 1 (right) are shown after being placed at a low temperature of 4°C, room temperature, and a high temperature of 50°C for 10 days respectively.

[0043] Depend on Figure 1 It can be seen that when the temperature gradually rises from the low temperature of 4°C to the room temperature and the high temperature of 50°C, the color of Example 1 is lighter than that of Comparative Example 1, and the degree of change is low. This is because the nanocellulose hydrogel and 1,3-butanediol can provide a relatively stable environment for deoxyarbutin when used in conjunction, effectively slowing down the decomposition rate of deoxyarbutin in water, and promoting the action time of deoxyarbutin in oil-free, low-oil or high-water content formulas, thereby enhancing the effect of deoxyarbutin.

[0044] 2. Compared with Example 1 in which nanocellulose hydrogel and butanediol are combined, Example 2 is comparatively free of nanocellulose hydrogel and comparative tests are performed at room temperature for 1 day, 7 days, and 21 days. Figure 2 Shown are the comparative changes of Example 1 (left) and Comparative Example 2 (right) at room temperature after 1 day, 7 days, and 21 days.

[0045] Depend on Figure 2 It can be seen that under the conditions of 1 day, 7 days and 21 days at room temperature, on the 7th day, Example 1 hardly changes in color, while the color of Comparative Example 2 becomes visibly darker. On the 21st day, Example 1 changes slightly in color, while the color of Comparative Example 2 becomes significantly darker, and the color is darker than that of Example 1. Therefore, the color change degree of Example 1 is lower than that of Comparative Example 2, and the color is lighter, indicating that when nanocellulose hydrogel and 1,3-butanediol are used in combination, deoxyarbutin decomposes slowly, and the resulting cosmetic composition is more stable.

[0046] In summary, the synergistic use of the nanocellulose hydrogel of the present invention and 1,3-butanediol can effectively promote the stability of deoxyarbutin in water, prolong the action time of deoxyarbutin in cosmetics with oil-free, low-oil or high-water content formulas, and delay the decomposition of deoxyarbutin in water, thereby prolonging the effect of deoxyarbutin.

[0047] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit it. Other modifications or equivalent substitutions made to the technical solution of the present invention by ordinary technicians in the field should be included in the scope of the claims of the present invention as long as they do not depart from the spirit and scope of the technical solution of the present invention.

Claims

1. A cosmetic composition containing deoxyarbutin, characterized in that: The invention is prepared from the following raw materials: by weight, 2% to 5% of deoxyarbutin, 9% to 20% of polyol, 0.7% to 1.5% of antibacterial agent, 50% to 75% of nanocellulose hydrogel, 0% to 5% of moisturizing agent, 0% to 1% of thickening agent, and the balance is deionized water.

2. The cosmetic composition containing deoxyarbutin according to claim 1, characterized in that: The weight ratio of the polyol to deoxyarbutin is 3-9:

1.

3. The cosmetic composition containing deoxyarbutin according to claim 1, characterized in that: The weight ratio of the nanocellulose hydrogel to deoxyarbutin is 15-25:

1.

4. The cosmetic composition containing deoxyarbutin according to claim 1, characterized in that: The mass concentration of dry cellulose in the nanocellulose hydrogel is 2-5 wt %.

5. The cosmetic composition containing deoxyarbutin according to claim 4, characterized in that: The diameter of dry cellulose in the nanocellulose hydrogel is 3-5 nm, and the aspect ratio is 180-300.

6. The cosmetic composition containing deoxyarbutin according to claim 1, characterized in that: The polyol is one or more of glycerol, butylene glycol, propylene glycol, sorbitol and polyethylene glycol.

7. The cosmetic composition containing deoxyarbutin according to claim 1, characterized in that: The antibacterial agent is one or more of ethylhexylglycerin, phenoxyethanol, p-hydroxyacetophenone, 1,2-hexanediol, p-hydroxybenzoic acid ester and salicylic acid.

8. The cosmetic composition containing deoxyarbutin according to claim 1, characterized in that: The moisturizing agent is one or more of niacinamide, sodium hyaluronate and vitamin E.

9. The cosmetic composition containing deoxyarbutin according to claim 1, characterized in that: The thickener is one or more of carbomer, xanthan gum, starch, acrylic acid and ethyl acrylate.

10. A method for preparing a cosmetic composition containing deoxyarbutin according to any one of claims 1 to 9, characterized in that: The steps include: (1) Mix deoxyarbutin and polyol, and stir evenly at room temperature to obtain a mixed solution A; (2) Evenly mix the moisturizer, thickener and deionized water to obtain a mixed solution B; (3) Add the mixed solution B and the mixed solution A to the nanocellulose hydrogel, add the antibacterial agent, stir evenly, and perform high-pressure homogenization to obtain the nanocellulose hydrogel.

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