Medicine for treating rhinitis sicca and preparation method thereof

Abstract

The invention discloses a medicine for treating rhinitis sicca, which is prepared from the following raw materials in parts by weight: 320 to 400 parts of sesame oil, 60 to 100 parts of fructus xanthii, 6 to 10 parts of flos magnoliae, 3 to 5 parts of radix angelicae, 3 to 5 parts of radix ligustici sinensis, 3 to 5 parts of radix paeoniae rubra, 1 to 3 parts of herba pogostemonis, 1 to 3 parts of folium perillae and 1 to 3 parts of herba hedyotidis diffusae. The invention further discloses a preparation method of the traditional Chinese medicine composition, so that the problems that the existing medicine is relatively strong in irritation, relatively strong in smell and relatively troublesome and uncomfortable in use process are solved.

Description

Technical Field

[0001] The invention relates to a Chinese medicine for external use and a preparation method thereof, in particular to a medicine for treating dry rhinitis and a preparation method thereof. Background Art

[0002] At present, both Chinese and Western medicine advocate local medication for dry rhinitis. In view of the pathological characteristics of dry nasal mucosa in patients with dry rhinitis, modern medicine advocates symptomatic treatment with compound menthol nasal drops and compound hibiscus nasal ointment as the main local moisturizing method. The dual effects of local moisturizing and mucosal repair of traditional Chinese medicine can better guarantee long-term efficacy.

[0003] Compound menthol nasal drops can promote the moistening of nasal mucosa, stimulate sensory nerve endings, and enhance the secretion of mucus by nasal mucosa, but they are highly irritating, have a strong odor, and have a strong local sensation. The menthol component contained in them can easily lead to allergic reactions. Compound hibiscus nasal ointment requires the ointment to be inserted deeply into the nasal cavity, which is troublesome to operate, cannot ensure that the nasal mucosa is evenly exposed to the drug, and the implementation process is uncomfortable, and children have poor compliance. Summary of the invention

[0004] The present invention aims to provide a medicine for treating dry rhinitis and a preparation method thereof, so as to solve the problems that the existing medicines are highly irritating, have a strong odor, and are troublesome and uncomfortable to use.

[0005] To achieve the above object, the present invention provides the following technical solution: a medicine for treating dry rhinitis, comprising the following raw materials by weight:

[0006] 320-400 parts of sesame oil, 60-100 parts of Xanthium sibiricum, 6-10 parts of magnolia, 3-5 parts of angelica dahurica, 3-5 parts of Ligusticum chuanxiong, 3-5 parts of red peony root, 1-3 parts of Patchouli, 1-3 parts of Perilla leaves, and 1-3 parts of Hedyotis diffusa.

[0007] Preferably, the preferred weight portions are: 368 parts of sesame oil, 80 parts of Xanthium sibiricum, 8 parts of Magnolia officinalis, 4 parts of Angelica dahurica, 4 parts of Ligusticum chuanxiong, 4 parts of Paeonia lactiflora, 2 parts of Patchouli, 2 parts of Perilla frutescens, and 2 parts of Hedyotis diffusa.

[0008] The preparation method of the above-mentioned medicine for treating dry rhinitis comprises the following steps:

[0009] Step 1: Screen the raw materials and take samples by weight;

[0010] Step 2: Soak Xanthium sibiricum in sesame oil for 24-30 hours, then add Magnolia officinalis, Ligusticum chuanxiong, Angelica dahurica and Paeonia lactiflora;

[0011] Step 3: Set the oil temperature to 100℃ and cook for 5-10 minutes until the Xanthium sibiricum turns slightly yellow;

[0012] Step 4: Heat the oil at 180℃ until the temperature reaches 145℃, then turn off the heat, add Patchouli, Perilla Leaf, and Hedyotis Diffusa, and stir evenly;

[0013] Step 5: Let stand, cool, filter, bottle and seal for storage.

[0014] The principle and beneficial effects of this technical solution:

[0015] This prescription uses Xanthium sibiricum and sesame oil as the main ingredients, and Magnolia officinalis and Angelica dahurica as the auxiliary ingredients, which are powerful in dispelling wind and cold and clearing the nasal passages. It is supplemented with Ligusticum chuanxiong, Patchouli, and Perilla leaves to dispel wind and dampness, and Hedyotis diffusa and Paeonia lactiflora to cool blood and reduce swelling, which can promote blood circulation, reduce swelling of nasal conchas, and help repair local nasal mucosa. Sesame oil is sweet and mild in nature, moisturizing and nourishing yin, which can not only moisten the nasal mucosa, but also block the damage to the mucosa by external factors. After being processed with sesame oil, the various drugs complement each other and can better play their effects of dispelling wind and clearing the passages, nourishing yin and moistening dryness.

[0016] The lungs and nose have a close relationship. For example, "Suwen·Jinkui Zhenlun Lun" says "the west is white in color, enters the lungs, and opens the orifices in the nose" and "Suwen·Five Zang Organs Formation Chapter" says "the lungs are connected to the skin, and their glory is the hair." The nasal mucosa also belongs to "skin and hair." Dry rhinitis is mainly manifested by local nasal mucosal symptoms. However, its onset is closely related to the internal state of the human body, and is particularly closely related to the lungs. The selection of the monarch and ministerial ingredients that enter the lung meridian and most of the adjuvants in the Qingbi Tongqiao Oil reflects the holistic view of traditional Chinese medicine and the concept of treating the disease at its root.

[0017] This pure Chinese herbal preparation not only has remarkable therapeutic effects, but also does not contain irritating ingredients. It has the advantages of few side effects and fewer adverse reactions. Local medication is less irritating, more convenient to use, has a stronger ability to promote nasal mucosa repair, and has more definite long-term efficacy, which is conducive to patients' adherence to long-term medication. DETAILED DESCRIPTION

[0018] The present invention is further described in detail below in conjunction with the embodiments:

[0019] A medicine for treating dry rhinitis, comprising the following raw materials by weight:

[0020] 320-400 parts of sesame oil, 60-100 parts of Xanthium sibiricum, 6-10 parts of magnolia, 3-5 parts of angelica dahurica, 3-5 parts of Ligusticum chuanxiong, 3-5 parts of red peony root, 1-3 parts of Patchouli, 1-3 parts of Perilla leaves, and 1-3 parts of Hedyotis diffusa.

[0021] The preparation method of the above-mentioned medicine for treating dry rhinitis comprises the following steps:

[0022] Step 1: Screen the raw materials and take samples by weight;

[0023] Step 2: Soak Xanthium sibiricum in sesame oil for 24-30 hours, then add Magnolia officinalis, Ligusticum chuanxiong, Angelica dahurica and Paeonia lactiflora;

[0024] Step 3: Set the oil temperature to 100℃ and cook for 5-10 minutes until the Xanthium sibiricum turns slightly yellow;

[0025] Step 4: Heat the oil at 180℃ until the temperature reaches 145℃, then turn off the heat, add Patchouli, Perilla Leaf, and Hedyotis Diffusa, and stir evenly;

[0026] Step 5: Let stand, cool, filter, bottle and seal for storage.

[0027] Embodiment 1:

[0028] A medicine for treating dry rhinitis is prepared by screening raw materials: 1840 grams of sesame oil, 400 grams of Xanthium sibiricum, 40 grams of Magnolia officinalis, 20 grams of Angelica dahurica, 20 grams of Ligusticum chuanxiong, 20 grams of Red Peony Root, 10 grams of Patchouli, 10 grams of Perilla Leaf, and 10 grams of Hedyotis diffusa; and the medicine is prepared by the above method.

[0029] Embodiment 2:

[0030] A medicine for treating dry rhinitis is prepared by screening raw materials: 1840 grams of Rhizoma Cibotii, 500 grams of Xanthium sibiricum, 50 grams of Magnolia officinalis, 25 grams of Angelica dahurica, 25 grams of Ligusticum chuanxiong, 25 grams of Paeonia lactiflora, 15 grams of Patchouli, 15 grams of Perilla frutescens, and 15 grams of Hedyotis diffusa, and preparing the medicine according to the above method.

[0031] Embodiment 3:

[0032] A medicine for treating dry rhinitis is prepared by screening raw materials: 1840 grams of sesame oil, 300 grams of Xanthium sibiricum, 30 grams of magnolia, 15 grams of angelica dahurica, 15 grams of Ligusticum chuanxiong, 15 grams of red peony root, 5 grams of Patchouli, 5 grams of Perilla frutescens, and 5 grams of Hedyotis diffusa, and preparing the medicine according to the above method.

[0033] Comparative Example 1:

[0034] Use the existing drug compound menthol nasal drops (approval number: E Wei Xiao Zheng Zi (2015) No. 0005).

[0035] Comparative Example 2:

[0036] Use existing medicated sesame oil.

[0037] Comparison of treatment effects:

[0038] 1. Case

[0039] 150 patients with dry rhinitis who meet the research design criteria will be treated in the TCM clinic of Xiling Branch of Yichang Central People's Hospital in 2024. (Case selection criteria: ① The diagnosis meets the diagnostic criteria of dry rhinitis symptoms and signs; ② The age is between 5 and 75 years old; ③ The patient voluntarily participates in this trial, signs the informed consent form, and fills in the relevant scale according to the facts)

[0040] 2. Treatment Methods

[0041] The patient was treated with the drugs of the three different embodiments and two comparative examples at 30:30:30:30:30:30, respectively, with nasal drops of the drugs, 1 drop in each nostril each time, 2 times a day. The treatment lasted for 2 weeks, and a return visit was conducted in the 4th week.

[0042] 3. Effect Evaluation

[0043] Clinical cure: nasal symptoms return to normal and physical signs basically disappear;

[0044] Markedly effective: Nasal symptoms are close to normal, and most signs disappear;

[0045] Effective: nasal symptoms and signs improved compared with before treatment;

[0046] Ineffective: No significant improvement in nasal symptoms and signs.

[0047] IV. Summary of efficacy

[0048] In the 4th week, the nasal symptoms of 6 patients who used the drug of Example 1 returned to normal and the physical signs basically disappeared, and the nasal symptoms of the remaining 24 patients were close to normal and the physical signs mostly disappeared.

[0049] In the 4th week, 10 patients who used the drug in Example 2 had nasal symptoms close to normal, with most of the signs disappearing, and the remaining 20 patients had nasal symptoms and signs improved compared with before treatment.

[0050] At week 4, the nasal symptoms and signs of all 30 patients who used the drug of Example 3 were improved compared with those before treatment.

[0051] In the 4th week, 5 patients with comparative example 1 had nasal symptoms close to normal, and most of the signs disappeared. The remaining 25 patients had nasal symptoms and signs improved compared with before treatment.

[0052] At week 4, 16 patients who used the drug in Comparative Example 2 had improved nasal symptoms and signs compared with before treatment, while the remaining 14 patients had no significant improvement in nasal symptoms and signs.

[0053] The clinical trials above prove that the present invention has a curative effect on dry rhinitis, and the drugs in the three embodiments are effective for patients, among which the drug ratio in embodiment 1 is the best. It can be seen from the two comparative examples that the drug of the present formula is more effective than the existing drugs.

[0054] The above is only an embodiment of the present invention, and the common knowledge such as the known specific technical solutions or characteristics in the solution is not described in detail here. For those skilled in the art, without departing from the technical solution of the present invention, several modifications and improvements can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicality of the patent. The scope of protection required by this application shall be based on the content of its claims, and the specific implementation methods and other records in the specification can be used to interpret the content of the claims.

Claims

1. A medicine for treating dry rhinitis, characterized in that: By weight, it contains the following raw materials: 320-400 parts of sesame oil, 60-100 parts of Xanthium sibiricum, 6-10 parts of magnolia, 3-5 parts of angelica dahurica, 3-5 parts of Ligusticum chuanxiong, 3-5 parts of red peony root, 1-3 parts of Patchouli, 1-3 parts of Perilla leaves, and 1-3 parts of Hedyotis diffusa.

2. A drug for treating dry rhinitis according to claim 1, characterized in that: The preferred weight portions are: 368 parts of sesame oil, 80 parts of Xanthium sibiricum, 8 parts of Magnolia officinalis, 4 parts of Angelica dahurica, 4 parts of Ligusticum chuanxiong, 4 parts of Paeonia lactiflora, 2 parts of Patchouli, 2 parts of Perilla frutescens, and 2 parts of Hedyotis diffusa.

3. A method for preparing the drug for treating dry rhinitis according to claim 1, characterized in that: The following steps are involved: Step 1: Screen the raw materials and take samples by weight; Step 2: Soak Xanthium sibiricum in sesame oil for 24-30 hours, then add Magnolia officinalis, Ligusticum chuanxiong, Angelica dahurica and Paeonia lactiflora; Step 3: Set the oil temperature to 100℃ and cook for 5-10 minutes until the Xanthium sibiricum turns slightly yellow; Step 4: Heat the oil at 180℃ until the temperature reaches 145℃, then turn off the heat, add Patchouli, Perilla Leaf, and Hedyotis Diffusa, and stir evenly; Step 5: Let stand, cool, filter, bottle and seal for storage.