Pre-period contraction and compensation intermittence control method and system and storage medium
By setting up the collector waveform tracing area and stimulation condition control area in medical animal experiments, and using stimulation control logic to regulate stimulator parameters, it solved the problem that it was difficult for experimental personnel to accurately grasp the rhythm of heartbeat, improved the experimental efficiency and reduced sample damage.
Patent Information
- Application Number
- CN202411439826.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-15
- Publication Date
- 2025-02-11
AI Technical Summary
In existing medical animal experiments, it is difficult for experimental personnel to accurately grasp the rhythm of the heartbeat, resulting in improper stimulation timing, low efficiency and damage to the experimental samples.
By setting the collector waveform tracing area, stimulator parameter setting area and stimulation condition control area, the stimulator parameters and conditions are regulated using the stimulation control logic to apply cardiac stimulation at a specific waveform position.
The accuracy and efficiency of the experimenter applying stimuli at specific waveform locations is improved, and damage to the experimental samples is reduced.
Smart Images
Figure CN119405992A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the field of medical animal experiment technology, and in particular to a control method, system and storage medium for premature contraction and compensatory interval. Background Art
[0002] After each myocardial excitation, its excitability will undergo a series of periodic changes, and it will go through several periods such as the effective refractory period, relative refractory period, supernormal period and subnormal period before it can return to its original normal level. Compared with other excitable tissues, the effective refractory period of the myocardium is particularly long, equivalent to the entire systolic period and early diastolic period. During this period, any strong stimulation cannot cause it to produce action potentials and contract. However, after the early diastolic period, a suprathreshold stimulation can cause the ventricular myocytes to produce an early contraction before the normal sinoatrial node automatic rhythm reaches the ventricle, which is called premature contraction (premature beat). Premature contraction also has its own effective refractory period. Therefore, when the normal rhythm of the sinoatrial node is transmitted to the ventricle, it happens to fall within the effective refractory period of premature contraction, so it cannot cause the myocardium to be excited and contracted again. It will not produce contraction until the normal rhythm of the sinoatrial node is transmitted to the myocardium again. The longer diastolic time of the ventricle after premature contraction is called compensatory interval.
[0003] In the existing stimulation experiment, the experimenter needs to stimulate the myocardium through the stimulation electrode according to the rhythm of the heartbeat at the corresponding myocardial contraction stage. This requires the experimenter to predict the rhythm. If the timing is wrong, repeated stimulation is required. The efficiency is low, and excessive stimulation can also cause great damage to the experimental samples. Summary of the invention
[0004] The purpose of the present invention is to overcome the deficiencies of the prior art and to provide a control method, system and storage medium for premature contraction and compensatory interval.
[0005] The object of the present invention is achieved through the following technical solutions: The first aspect of the present invention provides: a method for controlling premature contraction and compensatory interval, comprising the following steps: A collector waveform tracing area, a stimulator parameter setting area, and a stimulation condition control area are set; the collector waveform tracing area is used to trace and display the cardiac signal data collected by the signal collector as a cardiac contraction curve; the stimulator parameter setting area is used to set cardiac stimulator parameters; the stimulation condition control area is used to set cardiac stimulation conditions, so as to apply cardiac stimulation at the target waveform position; The stimulator parameter setting area and the stimulation condition control area are regulated according to the stimulation control logic, so as to obtain stimulation output at the user's target domain value point.
[0006] Preferably, the cardiac stimulator parameters include full-wave stimulation voltage, wave width, and frequency.
[0007] Preferably, the stimulation condition control area includes a starting threshold line, a direction arrow and an end threshold line; and the stimulation control logic includes the following steps: Complete the stimulation experiment preparation; In the stimulator parameter setting area, set the cardiac stimulator parameters; Set the starting domain value line between the trough and the user's target domain value point; Make the end point domain value line intersect with the user's target domain value point; Make the direction arrow point to the end value line; Click the start button in the stimulator parameter setting area, and then obtain a stimulation output at the user's target domain value point in the next myocardial contraction period.
[0008] Preferably, the starting threshold line, the ending threshold line and the collector waveform tracing area use the same scale.
[0009] The second aspect of the present invention provides: a control system for premature contraction and compensatory interval, which is used to implement any of the above-mentioned control methods for premature contraction and compensatory interval, comprising: The area setting module is used to set the collector waveform tracing area, the stimulator parameter setting area, and the stimulation condition control area; the collector waveform tracing area is used to trace and display the cardiac signal data collected by the signal collector as a cardiac contraction curve; the stimulator parameter setting area is used to set cardiac stimulator parameters; the stimulation condition control area is used to set cardiac stimulation conditions, so as to apply cardiac stimulation at the target waveform position; The stimulation control module is used to adjust the stimulator parameter setting area and the stimulation condition control area according to the stimulation control logic, so as to obtain stimulation output at the user's target domain value point.
[0010] The third aspect of the present invention provides: a computer-readable storage medium, wherein the computer-readable storage medium stores computer-executable instructions, and when the computer-executable instructions are loaded and executed by a processor, any of the above-mentioned methods for controlling premature contractions and compensatory intervals is implemented.
[0011] The beneficial effects of the present invention are: 1) It can solve the problem of experimenters' inaccurate grasp of timing and rhythm during the experiment, making it more convenient for experimenters to apply stimulation at specific waveform positions, which helps to improve scientific research efficiency. BRIEF DESCRIPTION OF THE DRAWINGS
[0012] Figure 1 This is a schematic diagram of the initial control interface; Figure 2 This is a schematic diagram of the control interface after the stimulation logic is executed; In the figure, 1. Collector waveform recording area; 2. Stimulator parameter setting area; 3. Starting domain value line; 4. Direction arrow; 5. Ending domain value line; 6. User target domain value point. DETAILED DESCRIPTION
[0013] The technical solution of the present invention will be clearly and completely described below in conjunction with the embodiments. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the present invention.
[0014] See also Figure 1-Figure 2 The first aspect of the present invention provides: a method for controlling premature contraction and compensatory interval, comprising the following steps: A collector waveform tracing area, a stimulator parameter setting area, and a stimulation condition control area are set; the collector waveform tracing area is used to trace and display the cardiac signal data collected by the signal collector as a cardiac contraction curve; the stimulator parameter setting area is used to set cardiac stimulator parameters; the stimulation condition control area is used to set cardiac stimulation conditions, so as to apply cardiac stimulation at the target waveform position; The stimulator parameter setting area and the stimulation condition control area are regulated according to the stimulation control logic, so as to obtain stimulation output at the user's target domain value point.
[0015] In this embodiment, the main function of the collector waveform tracing area is to trace and display the data collected by the signal collector hardware as a cardiac contraction curve on the computer monitor; the main function of the stimulation condition control area is to allow the experimenter to set appropriate stimulation conditions, that is, at which stage of myocardial contraction to output stimulation. This area is often superimposed or displayed in association with the collector waveform tracing area.
[0016] In some embodiments, the cardiac stimulator parameters include full-wave stimulation voltage, wave width, and frequency.
[0017] In some embodiments, the stimulation condition control area includes a starting threshold line, a direction arrow, and an end threshold line; and the stimulation control logic includes the following steps: Complete the stimulation experiment preparation; In the stimulator parameter setting area, set the cardiac stimulator parameters; Set the starting domain value line between the trough and the user's target domain value point; Make the end point domain value line intersect with the user's target domain value point; Make the direction arrow point to the end value line; Click the start button in the stimulator parameter setting area, and then obtain a stimulation output at the user's target domain value point in the next myocardial contraction period.
[0018] In this embodiment, the direction arrow can be as follows Figure 1-2 The domain line that points to the lower left or upper right, and the domain line that intersects with the starting point of the direction arrow is called the starting domain line, and the domain line that intersects with the end point of the direction arrow is called the end domain line; wherein the starting domain line and the end domain line can be moved vertically by dragging the mouse, and the direction arrow can be switched between pointing to the lower right and the upper right by clicking. The stimulation experiment preparation includes the following steps: 1. Destroy the brain and spinal cord of the experimental sample (toad); 2. Fix the experimental sample (toad) in a supine position on the frog board; 3. Cut the skin and chest wall of the experimental sample (toad) to expose the heart; 4. Cut the pericardium of the experimental sample (toad) to free the apex; 5. Clamp the apex with a frog heart clamp, adjust the position of the tension transducer, and draw a clear heart contraction curve in the signal acquisition system (including signal acquisition hardware and PC software); 6. Connect the stimulation electrode to the ventricular wall.
[0019] In some embodiments, the starting threshold line, the ending threshold line and the collector waveform tracing area use the same scale.
[0020] The second aspect of the present invention provides: a control system for premature contraction and compensatory interval, which is used to implement any of the above-mentioned control methods for premature contraction and compensatory interval, comprising: The area setting module is used to set the collector waveform tracing area, the stimulator parameter setting area, and the stimulation condition control area; the collector waveform tracing area is used to trace and display the cardiac signal data collected by the signal collector as a cardiac contraction curve; the stimulator parameter setting area is used to set cardiac stimulator parameters; the stimulation condition control area is used to set cardiac stimulation conditions, so as to apply cardiac stimulation at the target waveform position; The stimulation control module is used to adjust the stimulator parameter setting area and the stimulation condition control area according to the stimulation control logic, so as to obtain stimulation output at the user's target domain value point.
[0021] The third aspect of the present invention provides: a computer-readable storage medium, wherein the computer-readable storage medium stores computer-executable instructions, and when the computer-executable instructions are loaded and executed by a processor, any of the above-mentioned methods for controlling premature contractions and compensatory intervals is implemented.
[0022] The above is only a preferred embodiment of the present invention. It should be understood that the present invention is not limited to the form disclosed herein, and should not be regarded as excluding other embodiments, but can be used in various other combinations, modifications and environments, and can be modified within the scope of the concept described herein through the above teachings or the technology or knowledge of the relevant field. The changes and modifications made by those skilled in the art shall not deviate from the spirit and scope of the present invention, and shall be within the scope of protection of the claims attached to the present invention.
Claims
1. A method for controlling premature contraction and compensatory interval, characterized in that: The following steps are involved: A collector waveform tracing area, a stimulator parameter setting area, and a stimulation condition control area are set; the collector waveform tracing area is used to trace and display the cardiac signal data collected by the signal collector as a cardiac contraction curve; the stimulator parameter setting area is used to set cardiac stimulator parameters; the stimulation condition control area is used to set cardiac stimulation conditions, so as to apply cardiac stimulation at the target waveform position; The stimulator parameter setting area and the stimulation condition control area are regulated according to the stimulation control logic, so as to obtain stimulation output at the user's target domain value point.
2. The method for controlling premature contraction and compensatory pause according to claim 1, characterized in that: The cardiac stimulator parameters include full-wave stimulation voltage, wave width, and frequency.
3. The method for controlling premature contraction and compensatory pause according to claim 1, characterized in that: The stimulation condition control area includes a starting threshold line, a direction arrow and an end threshold line; the stimulation control logic includes the following steps: Complete the stimulation experiment preparation; In the stimulator parameter setting area, set the cardiac stimulator parameters; Set the starting domain value line between the trough and the user's target domain value point; Make the end point domain value line intersect with the user's target domain value point; Make the direction arrow point to the end value line; Click the start button in the stimulator parameter setting area, and then obtain a stimulation output at the user's target domain value point in the next myocardial contraction period.
4. The method for controlling premature contraction and compensatory pause according to claim 3, characterized in that: The starting domain value line, the ending domain value line and the waveform tracing area of the collector use the same scale.
5. A control system for premature contraction and compensatory interval, characterized in that: A method for controlling premature contraction and compensatory interval according to any one of claims 1 to 4, comprising: The area setting module is used to set the collector waveform tracing area, the stimulator parameter setting area, and the stimulation condition control area; the collector waveform tracing area is used to trace and display the cardiac signal data collected by the signal collector as a cardiac contraction curve; the stimulator parameter setting area is used to set cardiac stimulator parameters; the stimulation condition control area is used to set cardiac stimulation conditions, so as to apply cardiac stimulation at the target waveform position; The stimulation control module is used to adjust the stimulator parameter setting area and the stimulation condition control area according to the stimulation control logic, so as to obtain stimulation output at the user's target domain value point.
6. A computer-readable storage medium, characterized in that: The computer-readable storage medium stores computer-executable instructions, and when the computer-executable instructions are loaded and executed by the processor, the method for controlling premature contractions and compensatory intervals as described in any one of claims 1 to 4 is implemented.