Magnetic field enhanced flexible plasma pad

Abstract

The invention relates to a magnetic field enhanced flexible plasma pad, which comprises a flexible pad body and a permanent magnet, the flexible pad body comprises a flexible insulating layer, a flexible high-voltage electrode, a flexible dielectric layer and a flexible grounding grid electrode which are arranged in sequence, and a plurality of small holes are formed in the grounding grid electrode in a penetrating manner; the permanent magnet is arranged on one side of the flexible pad body and used for generating a magnetic field. According to the magnetic field enhanced flexible plasma pad, voltage is applied to the flexible high-voltage electrode and the flexible grounding grid electrode of the flexible pad body, so that a large number of active particle components, namely cold plasmas, capable of promoting wound healing and killing bacteria can be generated in small holes of the flexible grounding grid electrode at normal temperature and normal pressure; meanwhile, the permanent magnet is arranged, the permanent magnet can generate a magnetic field, the performance of the plasma can be enhanced, and therefore the plasma treatment effect can be improved.

Description

Technical Field

[0001] The invention relates to the technical field of medical instruments, and in particular to a magnetic field enhanced flexible plasma pad. Background Art

[0002] In some developed countries, infected wounds are a major health problem. 1% of the population suffers from continuous trauma. The cost of treating these wounds accounts for about 2% to 3% of the total budget of the health care system. In clinical practice, there are various treatment strategies for wound healing, such as the most common drug therapy, growth factor therapy, epidermal stem cell transplantation, spray and stem cell therapy. Although there are many methods, there are still many limitations, such as drug resistance, high price, and complex operation. Therefore, new treatment methods are urgently needed to promote wound healing, especially complex chronic wounds.

[0003] Various types of wearable plasma devices are available in the form of plasma pads, plasma bandages, plasma socks, and plasma caps. However, unlike conventional plasma jet or dielectric barrier discharge (DBD) devices, wearable devices have attracted much attention due to their diverse applications and convenience. Therefore, since DBDs are not limited by treatment time and treatment area size, it has been proposed to integrate DBDs in adhesive devices for use on human limbs. However, existing flexible plasma devices still need to be improved in terms of performance. Summary of the invention

[0004] Based on this, the purpose of the present invention is to provide a magnetic field enhanced flexible plasma pad, which can generate a magnetic field by setting a permanent magnet, thereby enhancing the performance of plasma and improving the cold plasma treatment effect.

[0005] To achieve the above object, the present invention adopts the following technical solutions: The present invention provides a magnetic field enhanced flexible plasma pad, which comprises a flexible pad body and a permanent magnet; the flexible pad body comprises a flexible insulating layer, a flexible high-voltage electrode, a flexible dielectric layer, and a flexible grounding grid electrode which are arranged in sequence, and a plurality of small holes are penetrated through the grounding grid electrode; the permanent magnet is arranged on one side of the flexible pad body and is used to generate a magnetic field.

[0006] The magnetic field enhanced flexible plasma pad of the present invention can generate a large number of active particle components that can promote wound healing and kill bacteria, namely cold plasma, in the small holes of the flexible grounding grid electrode at normal temperature and pressure by applying voltage to the flexible high-voltage electrode and the flexible grounding grid electrode of the flexible pad body, thereby promoting wound healing and killing bacteria at the wound. At the same time, by arranging a permanent magnet, the permanent magnet can generate a magnetic field, which can enhance the performance of the plasma, thereby improving the plasma treatment effect.

[0007] As a further improvement of the above solution of the present invention, the flexible pad has a circular structure with a diameter of 20-40 mm, a frequency of 4.5 kHz-9.0 kHz, and a peak voltage of 3.2-6.4 KV. The circular structure can reduce the plasma damping effect, help achieve uniform electric field enhancement, and help achieve a more uniform treatment effect.

[0008] As a further improvement of the above solution of the present invention, the multiple small holes on the flexible grounding grid electrode are distributed in a matrix.

[0009] As a further improvement of the above solution of the present invention, each small hole is a circular hole with a diameter of 1 mm to 3 mm, and the side length of the matrix is ​​15 mm to 35 mm.

[0010] As a further improvement of the above solution of the present invention, the flexible insulating layer is made of polyimide and has a thickness of 35 μm to 65 μm.

[0011] As a further improvement of the above solution of the present invention, the flexible dielectric layer is made of polyimide and has a thickness of 80 μm to 120 μm.

[0012] As a further improvement of the above solution of the present invention, the flexible high-voltage electrode and the flexible grounding grid electrode are both copper electrodes.

[0013] Compared with the prior art, the present invention has the following beneficial effects: 1. The magnetic field enhanced flexible plasma pad of the present invention can generate a large number of active particle components that can promote wound healing and kill bacteria, namely cold plasma, in the small holes of the flexible grounding grid electrode at room temperature and pressure by applying voltage to the flexible high-voltage electrode and the flexible grounding grid electrode of the flexible pad body, thereby promoting wound healing and killing bacteria at the wound. At the same time, a magnetic field is generated by the permanent magnet to enhance the performance of the plasma, thereby improving the plasma treatment effect.

[0014] 2. The magnetic field enhanced flexible plasma pad of the present invention can be bent arbitrarily according to different parts of the human body to fit closely with the skin, and can be used for wound treatment in different parts of the human body, thus expanding the scope of application.

[0015] 3. The invention has a simple structure, reasonable design, easy use, safe and reliable performance, and broad market prospects. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 A schematic diagram of the structure of a magnetic field enhanced flexible plasma pad proposed in an embodiment of the present invention; Figure 2 A schematic diagram of the structure of a flexible grounding grid electrode in a magnetic field enhanced flexible plasma pad proposed in an embodiment of the present invention; Figure 3 The graph of cell viability changes of keratinocytes treated with plasma in the embodiment and the comparative example and incubated for 24 hours; Figure 4 This is a graph showing the colony changes of Staphylococcus aureus after plasma treatment for 24 hours in the embodiments and comparative examples; Figure 5 This is a graph showing the colony changes of Escherichia coli after plasma treatment in the embodiments and comparative examples and the colony changes after 24 hours.

[0017] Figure numerals: 1. flexible insulating layer; 2. flexible high-voltage electrode; 3. flexible dielectric layer; 4. flexible grounding grid electrode; 41. small hole; 5. permanent magnet. DETAILED DESCRIPTION

[0018] For ease of understanding of the present invention, the present invention will be described more fully below in conjunction with specific embodiments. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present invention more thoroughly understood.

[0019] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art of the present invention. The terms used in the specification of the present invention herein are only for the purpose of describing specific embodiments and are not intended to limit the present invention.

[0020] Example Reference Figure 1 This embodiment provides a magnetic field enhanced flexible plasma pad, which includes a flexible pad body and a permanent magnet 5.

[0021] The flexible pad body includes a flexible insulating layer 1, a flexible high-voltage electrode 2, a flexible dielectric layer 3 and a flexible grounding grid electrode 4 arranged in sequence. In this embodiment, the flexible insulating layer 1, the flexible high-voltage electrode 2, the flexible dielectric layer 3 and the flexible grounding grid electrode 4 can be bonded by glue. In this embodiment, the flexible pad body has a circular structure and its overall diameter is 30 mm. Of course, in other embodiments, as long as the use requirements are met, the flexible pad body can also be 20 mm, 35 mm, 40 mm or other diameters, and the flexible pad body can also be square, oval or other shapes.

[0022] In this embodiment, the flexible insulating layer 1 is a circular structure, which is made of polyimide material, with a diameter of 30 mm and a thickness of 50 μm. The flexible insulating layer 1 mainly prevents electric shock injuries and plays a role in insulation safety. Of course, in other embodiments, the flexible insulating layer 1 can also be made of other insulating materials such as silicone rubber.

[0023] In this embodiment, the flexible high-voltage electrode 2 uses a copper electrode, which is in a circular structure with a diameter of 30 mm. In this embodiment, the flexible high-voltage electrode 2 is provided with a wiring port to facilitate the connection of the flexible high-voltage electrode 2 with an external power source.

[0024] In this embodiment, the flexible dielectric layer 3 is made of polyimide material, has a circular structure as a whole, and has a thickness of 100 μm. Of course, in other embodiments, the flexible insulating layer 1 can also be made of other insulating materials such as silicone rubber.

[0025] In this embodiment, the flexible grounding grid electrode 4 is made of copper electrode, which is in a circular structure and has a thickness of 85 μm. Figure 2 The flexible grounding mesh electrode 4 is provided with a plurality of small holes 41, each of which is a circular hole with a diameter of 1.5 mm, and the plurality of small holes 41 are distributed in a matrix, and the side length of the matrix is ​​20 mm. In this embodiment, the flexible grounding mesh electrode 4 is provided with a wiring port to facilitate the connection of the flexible grounding mesh electrode 4 with an external power source. Of course, in other embodiments, each small hole 41 may also be a square, oval or other shaped hole.

[0026] The above-mentioned structural setting of the flexible pad body of the present embodiment makes the flexible pad body have the characteristic of being bendable, so that the flexible pad body can be bent at will according to different parts of the human body to fit closely with the skin, and can be used for wound treatment in different parts of the human body, thereby expanding the scope of application; by applying voltage to the flexible high-voltage electrode 2 and the flexible grounding grid electrode 4, a large number of active particle components that can promote wound healing and kill bacteria, i.e., cold plasma, can be generated in the small holes 41 of the flexible grounding grid electrode 4 at normal temperature and pressure, thereby promoting wound healing and killing bacteria at the wound.

[0027] In the present embodiment, the permanent magnet 5 is arranged on one side of the flexible pad. In the present embodiment, when in use, the permanent magnet 5 is arranged on the side of the flexible pad away from the skin, and the permanent magnet 5 can generate a magnetic field, which can enhance the performance of the plasma generated by the flexible pad. In the present embodiment, the permanent magnet 5 can be arranged in a circular structure, and the diameter of the permanent magnet 5 is greater than the diameter of the flexible pad. Of course, in other embodiments, in order to improve the effect, the permanent magnet 5 can also be arranged on the side of the flexible pad facing the skin, and the permanent magnet 5 can be arranged in a contoured structure so that the permanent magnet 5 can fit the position of the skin wound.

[0028] The frequency of the magnetic field enhanced flexible plasma pad of this embodiment is 6.83 kHz, and the peak voltage is 4.8 KV.

[0029] When the magnetic field enhanced flexible plasma pad of this embodiment is used, the flexible pad body is brought into contact with the skin wound, and the bending degree of the flexible pad body can be changed according to the wound position to attach the flexible pad body to the skin wound position, and then the flexible high-voltage electrode 2 and the flexible grounding grid electrode 4 are connected to an external power supply, and an AC voltage is applied to the flexible high-voltage electrode 2 and the flexible grounding grid electrode 4. Air is used as the working gas, and cold plasma can be generated in the small hole 41 of the flexible grounding grid electrode 4 at normal temperature and pressure. The cold plasma reaches the skin wound position, promotes wound healing and kills bacteria at the wound. At the same time, a magnetic field is generated by the permanent magnet 5 to enhance the performance of the cold plasma and improve the treatment effect; the flexible high-voltage electrode 2 and the flexible grounding grid electrode 4 are respectively made on the upper and lower surfaces of the flexible dielectric layer 3, and the surface of the flexible high-voltage electrode 2 is covered with a flexible insulating layer 1. No voltage and current are generated on the surface of the flexible grounding grid electrode 4, so it has electrical safety, can effectively prevent electric shock injuries, and ensure safety in use.

[0030] Comparative Example This comparative example proposes a flexible plasma pad. This comparative example adopts the same implementation as the embodiment, but is different from the embodiment in that the flexible plasma pad of this comparative example does not include a permanent magnet.

[0031] Test Case (1) Improve cell viability performance test The magnetic field enhanced flexible plasma pad (denoted as LTP+SMF) of the embodiment and the flexible plasma pad (denoted as LTP) of the comparative example were used to perform continuous plasma stimulation treatment on keratinocytes (HaCaT cells) for 0s, 30s, 60s, 90s, 120s, and 150s, respectively. Cell viability was measured after incubation for 24h. The test results are shown in FIG. Figure 3 As shown, Figure 3 Data are the mean ± SD of three independent experiments, ***p < 0.001, compared with the untreated group (i.e., treatment 0s group) using analysis of variance.

[0032] from Figure 3It can be seen that for HaCaT cells, compared with the untreated group (i.e., the treatment 0s group), the activity of HaCaT cells treated with plasma for 60s and 90s was significantly increased, and the activity of HaCaT cells reached a peak when the treatment was 60s. When the plasma treatment time was increased to 120s and 150s, the cell survival rate dropped sharply, which was significantly lower than that of the untreated group. Compared with the plasma treatment alone in the comparative example, the magnetic field combined with plasma treatment in the embodiment significantly increased the cell viability when the treatment was 30s and 60s. When the treatment time was 90s, 120s and 150s, the magnetic field combined with plasma treatment decreased the cell viability more. This shows that the plasma treatment of HaCaT cells by the magnetic field enhanced flexible plasma pad of the present application can improve the viability of HaCaT cells (HaCaT cells are an important cellular component in the wound healing process), is beneficial to wound healing, and the presence of the magnetic field enhances the performance of the plasma.

[0033] (2) Bacterial killing performance test ① The magnetic field enhanced flexible plasma pad of the embodiment (referred to as LTP+SMF) and the flexible plasma pad of the comparative example (referred to as LTP) were respectively applied to a Staphylococcus aureus culture dish (the initial concentration of Staphylococcus aureus was about 10 7 / mL) were continuously treated with plasma for 0s, 30s, 60s, 90s, 120s, and 150s. After 24h, the CFU counting method was used to quantify the inactivation efficiency of plasma on Staphylococcus aureus. The test results are shown in Figure 4 shown.

[0034] ② The magnetic field enhanced flexible plasma pad of the embodiment (referred to as LTP+SMF) and the flexible plasma pad of the comparative example (referred to as LTP) were respectively subjected to the test (the initial concentration of Escherichia coli was about 10 7 / mL) were continuously treated with plasma for 0s, 30s, 60s, 90s, 120s, and 150s. After 24h, the CFU counting method was used to quantify the inactivation efficiency of plasma on Escherichia coli. The test results are shown in Figure 5 shown.

[0035] from Figure 4 , Figure 5 It can be seen that when the plasma treatment time reaches 30s, the number of the two bacteria decreases by 10 orders of magnitude; when the treatment time reaches 90s, the number of the two bacteria suddenly decreases, and the number of the two bacteria decreases by 10 4 When the treatment time reached 150s, the number of both bacteria was less than 10 2Compared with the plasma treatment alone in the comparative example, the magnetic field plasma combined treatment of the embodiment has better effect. For the same treatment time, the combined treatment of magnetic field and plasma has better inhibitory effect on bacteria and less bacteria. This shows that the magnetic field enhanced flexible plasma pad of the present application shows excellent effect in killing bacteria through the combined treatment of magnetic field and plasma, and can kill bacteria quickly and effectively. The presence of the magnetic field enhances the performance of plasma.

[0036] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0037] The above-mentioned embodiments only express several implementation methods of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A magnetic field enhanced flexible plasma pad, characterized in that: It comprises a flexible pad body and a permanent magnet (5); the flexible pad body comprises a flexible insulating layer (1), a flexible high-voltage electrode (2), a flexible dielectric layer (3), and a flexible grounding grid electrode (4) which are arranged in sequence, and a plurality of small holes (41) are provided through the grounding grid electrode; the permanent magnet (5) is arranged on one side of the flexible pad body and is used to generate a magnetic field.

2. The magnetic field enhanced flexible plasma pad according to claim 1, characterized in that: The flexible pad body is in a circular structure, with a diameter of 20-40 mm, a frequency of 4.5 kHZ-9.0 kHZ, and a peak voltage of 3.2-6.4 KV.

3. The magnetic field enhanced flexible plasma pad according to claim 1, characterized in that: The plurality of small holes (41) on the flexible grounding grid electrode (4) are distributed in a matrix.

4. The magnetic field enhanced flexible plasma pad according to claim 3, characterized in that: Each small hole (41) is a circular hole with a diameter of 1 mm to 3 mm, and the side length of the matrix is ​​15 mm to 35 mm.

5. The magnetic field enhanced flexible plasma pad according to claim 1, characterized in that: The flexible insulating layer (1) is made of polyimide and has a thickness of 35 μm to 65 μm.

6. The magnetic field enhanced flexible plasma pad according to claim 1, characterized in that: The flexible medium layer (3) is made of polyimide and has a thickness of 80 μm to 120 μm.

7. The magnetic field enhanced flexible plasma pad according to claim 1, characterized in that: The flexible high-voltage electrode (2) and the flexible grounding grid electrode (4) are both made of copper electrodes.

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