Traditional Chinese medicine combined medicament and preparation process method thereof

Abstract

The invention relates to a traditional Chinese medicine combined medicament, which uses a combination of a plurality of medicament extracts which are easy to digest, excrete, warm and tonify as pills, and comprises a folium sennae extract pill, a rhizoma alismatis extract pill, a poria cocos extract pill, a semen cassiae extract pill, an angelica sinensis extract pill, a cinnamon extract pill and a lavender extract pill. A good weight-losing effect is achieved. According to different materials of the used raw materials, the extraction process is optimized, when the angelica sinensis is extracted, due to the fact that when an extract is obtained through an existing extraction process, the content of various active ingredients is often reduced, the effectiveness is reduced, and application is not facilitated, the multi-effect extraction process is provided, the various active ingredients can be reserved, and the extraction efficiency is improved. Effectiveness is prevented from being obviously reduced, and the value is improved.

Description

Technical Field

[0001] The invention relates to the technical field of food and health products, and in particular to a preparation process and product of an efficient Chinese medicine combination medicament. Background Art

[0002] With the increase in the number of obese people, the market size of weight loss drugs continues to expand. Traditional Chinese medicine weight loss drugs are favored by the market because of their small side effects and significant efficacy. In 2020, the market size of weight loss drugs increased to 1.9 billion yuan, a year-on-year increase of 72.73%. At the same time, the weight loss drug market is also facing challenges such as the diversification of consumers' choices of weight loss drugs, brand competition and product differentiation. More manufacturers are willing to increase their investment in the research and development of weight loss drugs, which has become a new research and development hotspot.

[0003] According to TCM theory, obesity is mainly related to spleen and kidney yang deficiency, hyperactivity of stomach fire, and imbalance of qi and blood. The principle of weight loss with Chinese medicine is mainly to achieve the purpose of weight loss by harmonizing the balance of yin and yang in the human body, the circulation of qi and blood, and the function of internal organs. Different Chinese medicines have different weight loss principles, which can be divided into: regulating the spleen and stomach, promoting water and dampness, promoting blood circulation and removing blood stasis, clearing away heat and detoxifying, nourishing yin and reducing fire, nourishing the liver and kidney, regulating endocrine, promoting intestinal peristalsis, and improving metabolism. Chinese medicine with the same origin of medicine and food shows the characteristics of safety and effectiveness in the treatment of obesity. For example, the specific chemical components contained in Phyllanthus emblica and Cassia seed can inhibit fat accumulation and reduce blood lipids. Due to the good characteristics of Chinese medicine with the same origin of medicine and food, people generally accept Chinese medicine weight loss agents, forming a variety of Chinese medicine weight loss agents, and achieving good results and economic benefits.

[0004] However, in the traditional preparation process of Chinese herbal medicine for weight loss, the medicinal materials are usually steamed and concentrated to obtain the extract of the Chinese medicine, and then the extract is prepared into the medicine. However, the traditional steaming method has a complicated extraction process and low extraction efficiency, which makes the preparation cost of the Chinese medicine medicine high and the benefit low. How to extract the Chinese medicinal materials and prepare the medicine in an efficient and simple process is a widespread problem currently faced in the preparation process of Chinese medicine medicine.

[0005] Although there are a variety of extraction processes used in the prior art, such as microwave extraction, water extraction and alcohol precipitation, the development of new processes is currently less, and most of the preparations of Chinese medicine are only the screening of Chinese medicine raw materials, and the problem of improving the preparation process is not fully considered. Plant raw materials can be divided into different parts such as leaves, stems, and roots in Chinese medicine raw materials. Among them, Chinese medicine extracts as leaves are easier to extract due to their texture, and for stems and roots, due to their thicker and harder cell wall structure, it is easy to cause the effectiveness of the extract to decrease during extraction. Conventional extraction processes in the prior art are often used, such as microwave extraction, water extraction, and alcohol extraction, which are easy to cause the type and content of the extracted active ingredients to be relatively reduced, which is not conducive to its application, resulting in the problem of reduced effectiveness of the medicinal materials. Especially for the many raw materials used in the present invention, the inventor found that the problem of reduced effectiveness of angelica sinensis during extraction, such as, ferulic acid showed a lower or difficult to show extraction content in some existing extraction processes, resulting in the reduction of some active ingredients and the inability to effectively retain, so it is necessary to optimize and improve the angelica sinensis extraction process in the raw material. Summary of the invention

[0006] The purpose of the present invention is to provide a Chinese medicine extraction process different from the prior art, by optimizing the process steps, so that the complexity and time length of the process are reduced, and the efficiency of the process is significantly improved, so as to solve the problems raised in the above background technology.

[0007] To achieve the above object, the present invention provides the following technical solutions:

[0008] First, the present invention provides a combination of Chinese medicine weight loss pills, characterized in that it includes the following Chinese medicine pills, the Chinese medicine pills are respectively senna leaf extract pills, oriental rhizome extract pills, tuckahoe extract pills, cassia seed extract pills, angelica extract pills, cinnamon extract pills, and lavender extract pills. When used, one pill is used every day, and 21 days is used as a use cycle.

[0009] Secondly, in view of the shortcomings of the prior art, the present invention provides a multi-effect Chinese herbal medicine extraction process by optimizing the extraction process, thereby improving the effectiveness of the herbal medicine extract. Specifically, according to the type of Chinese herbal medicine raw materials used in the pills, the present invention provides a multi-effect preparation process of angelica extract in view of the problem of reduced effectiveness of angelica during extraction, comprising the following steps:

[0010] (1) washing and removing impurities from the angelica sinensis, and then drying the angelica sinensis to obtain pretreated angelica sinensis;

[0011] (2) spraying the pretreated angelica with deionized water so that the moisture content of the angelica is maintained at 60%-80%, thereby obtaining a moistened angelica;

[0012] (3) The wetted angelica is subjected to freezing treatment, wherein the freezing treatment is carried out at -15°C to -25°C so that the inside of the wetted angelica can be completely frozen and frozen. After standing for a period of time, the angelica is subjected to a thawing treatment so that the ice inside the angelica is completely melted.

[0013] (4) coarsely crushing the angelica obtained in step (3) to obtain angelica slices;

[0014] (5) preparing an ultrasonic treatment liquid, mixing water and ethanol in a volume ratio of 3:1-2 to obtain an ultrasonic treatment liquid, immersing the Angelica sinensis fragments obtained in step (4) in the ultrasonic treatment liquid at a solid-liquid ratio of 1:25-30, performing ultrasonic treatment, and filtering and separating to obtain a supernatant and a solid separator;

[0015] (6) subjecting the solid isolate obtained in step (5) to low-temperature drying to obtain a dry solid isolate; adding the dry solid isolate to a 60%-80% ethanol solution, heating and refluxing for extraction for 0.5-1 h to obtain an extract;

[0016] (7) Mixing the supernatant obtained in step (5) and the extract obtained in step (6) to obtain a mixed extract, and concentrating the mixed extract by rotary evaporation to obtain a concentrated solution, that is, a multi-effect extract; adding the multi-effect extract to the auxiliary materials to obtain angelica extract pills.

[0017] As a further preferred embodiment, the angelica sinensis is removed from the soil and cleaned in step (1) by placing the angelica sinensis in a soaking tank for rinsing and soaking, then taken out and air-dried to obtain pretreated angelica sinensis, thereby avoiding the influence of dirt, dust, impurities, etc. attached to the whole angelica sinensis.

[0018] As a further preferred embodiment, in step (2), the moisture content of the angelica is first measured, and the angelica is sprayed according to the measured moisture content, so as to avoid water waste during the spraying process and the moisture content of the angelica after spraying exceeding the required moisture content target.

[0019] As a further preferred embodiment, the freezing treatment time in step (3) is 20-30 minutes, and the mixture is allowed to stand for 0.5-1 hour after freezing.

[0020] As a further preferred embodiment, in step (4), a grinder is used to coarsely grind the angelica into fragments of 3mm-5mm in length. The coarse grinding method is conducive to the subsequent efficient extraction of multi-functional active substances and can avoid the introduction of excessive impurities.

[0021] As a further preferred embodiment, in step (5), the ratio of water to ethanol is 3:1, the ultrasonic treatment time is 20-30 minutes, and the material-liquid ratio is 1:30. As a further preferred embodiment, in step (6), the temperature of low-temperature drying is 25-40°C, the drying time is 4-6 hours; the concentration of the ethanol solution used is 70%, and the heating reflux time is 40 minutes.

[0022] Beneficial Effects

[0023] First, the seven pills used in the present invention have the advantages of being easy to use and having long-lasting efficacy. One pill a day can be used conveniently. Secondly, the present invention realizes efficient extraction of angelica in the raw material. In the prior art, extraction methods such as extraction and solvent reflux can often obtain extracts with a single category of component content that meets the requirements during extraction, and the active ingredients of multiple medicinal materials are significantly reduced during extraction; and although the existing decoction extraction of Chinese medicinal materials can retain Chinese medicinal materials to obtain multi-effect extraction during hot water immersion, the extract is difficult to dissolve efficiently, the extraction efficiency is low, and impurity components are easily introduced, and the extraction content of some volatile components and the dissolved components shows a large difference. Therefore, the prior art does not provide a multi-effect extraction process that retains multiple components. The present invention wets, freezes and thaws, coarsely crushes, and ultrasonically extracts the pretreated angelica successively, wherein, in order to achieve efficient precipitation of multiple components such as amino acids, organic acids, angelic acid ketone, etc. inside the angelica cells, at the same time, the treatment method adopted is mild, and while enhancing the exudation of multiple active ingredients, impurities caused by severe damage to the cells are avoided. By maintaining the water content after spraying at 60-80%, the degree of freezing inside the cells is controlled during freezing, and partial damage to the cells is obtained. Freezing creates pores on the cells, which not only creates micropores that are conducive to the dissolution of active substances in the cells, but also does not cause greater damage to the cells. The freezing treatment is combined with the coarse crushing treatment to avoid the various impurities that appear in the powder during grinding and crushing when the powder is crushed to several tens of meshes during the dry crushing in the prior art. The extraction is still carried out under the condition of maintaining the structure of Angelica sinensis. At the same time, in order to maintain efficient dissolution, the Angelica sinensis that has been frozen is subjected to ultrasonic extraction. Under the treatment conditions of a mixed solution of water and ethanol, a variety of water-soluble or alcohol-soluble active substances can be dissolved. Due to the use of a mixed solution mainly composed of water, more water-soluble extracts can be dissolved during extraction, and a small amount of alcohol-soluble substances can be dissolved at the same time, which can be extracted in conjunction with subsequent ethanol heating and reflux. After ultrasonic extraction, since some active substances have been dissolved, the remaining difficult-to-dissolve active substances still exist in the Angelica sinensis, and then the solvent reflux heating extraction is used to extract the remaining active substances in the Angelica sinensis, and the Angelica sinensis is efficiently utilized. DETAILED DESCRIPTION

[0024] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0025] Example 1

[0026] A preparation process of angelica extract pills, characterized by comprising the following specific steps:

[0027] (1) washing and removing impurities from the angelica sinensis, and then drying the angelica sinensis to obtain pretreated angelica sinensis;

[0028] (2) spraying the pretreated angelica with deionized water to maintain the moisture content of the angelica at 70%, thereby obtaining a moistened angelica;

[0029] (3) The wetted angelica is subjected to freezing treatment at a temperature of -20°C, so that the wetted angelica can be completely frozen inside. After standing for a period of time, the angelica is subjected to thawing treatment, and the ice inside the angelica is completely melted. The freezing treatment time is 25 minutes, and the angelica is allowed to stand for 1 hour after freezing.

[0030] (4) coarsely crushing the angelica obtained in step (3) to obtain angelica fragments;

[0031] (5) preparing an ultrasonic treatment liquid, mixing water and ethanol in a volume ratio of 3:1 to obtain an ultrasonic treatment liquid, immersing the Angelica sinensis fragments obtained in step (4) in the ultrasonic treatment liquid at a solid-liquid ratio of 1:25, performing ultrasonic treatment, and filtering and separating to obtain a supernatant and a solid separator;

[0032] (6) subjecting the solid isolate obtained in step (5) to low-temperature drying to obtain a dry solid isolate; adding the dry solid isolate to a 70% ethanol solution, heating and refluxing for extraction for 1 hour to obtain an extract; the low-temperature drying temperature is 30° C., and the drying time is 6 hours;

[0033] (7) Mixing the supernatant obtained in step (5) and the extract obtained in step (6) to obtain a mixed extract, and concentrating the mixed extract by rotary evaporation to obtain a concentrated solution, that is, a multi-effect extract.

[0034] Example 2

[0035] A preparation process of angelica extract pills, characterized by comprising the following specific steps:

[0036] (1) washing and removing impurities from the angelica sinensis, and then drying the angelica sinensis to obtain pretreated angelica sinensis;

[0037] (2) spraying the pretreated angelica with deionized water to maintain the moisture content of the angelica at 70%, thereby obtaining a moistened angelica;

[0038] (3) The wetted angelica is subjected to freezing treatment, wherein the freezing treatment temperature is -25°C, so that the wetted angelica can be completely frozen inside, and after standing for a period of time, the angelica is subjected to thawing treatment, and the ice inside the angelica is completely melted. The freezing treatment time is 20 minutes, and the angelica is allowed to stand for 0.5 hours after freezing.

[0039] (4) coarsely crushing the angelica obtained in step (3) to obtain angelica fragments;

[0040] (5) preparing an ultrasonic treatment liquid, mixing water and ethanol in a volume ratio of 3:1 to obtain an ultrasonic treatment liquid, immersing the Angelica sinensis fragments obtained in step (4) in the ultrasonic treatment liquid at a solid-liquid ratio of 1:30, performing ultrasonic treatment, and filtering and separating to obtain a supernatant and a solid separator;

[0041] (6) subjecting the solid isolate obtained in step (5) to low-temperature drying to obtain a dry solid isolate; adding the dry solid isolate to a 70% ethanol solution, heating and refluxing for extraction for 1 hour, and obtaining an extract; the low-temperature drying temperature is 40° C., and the drying time is 4 hours;

[0042] (7) Mixing the supernatant obtained in step (5) and the extract obtained in step (6) to obtain a mixed extract, and concentrating the mixed extract by rotary evaporation to obtain a concentrated solution, that is, a multi-effect extract.

[0043] Example 3

[0044] A preparation process of angelica extract pills, characterized by comprising the following specific steps:

[0045] (1) washing and removing impurities from the angelica sinensis, and then drying the angelica sinensis to obtain pretreated angelica sinensis;

[0046] (2) spraying the pretreated angelica with deionized water to maintain the moisture content of the angelica at 60%, thereby obtaining a moistened angelica;

[0047] (3) The wetted angelica is subjected to freezing treatment, wherein the freezing treatment temperature is -15°C, so that the wetted angelica can be completely frozen inside, and after standing for a period of time, the angelica is subjected to thawing treatment, and the ice inside the angelica is completely melted. The freezing is allowed to stand for 1 hour.

[0048] (4) coarsely crushing the angelica obtained in step (3) to obtain angelica fragments;

[0049] (5) preparing an ultrasonic treatment liquid, mixing water and ethanol in a volume ratio of 3:2 to obtain an ultrasonic treatment liquid, immersing the Angelica sinensis fragments obtained in step (4) in the ultrasonic treatment liquid at a solid-liquid ratio of 1:25, performing ultrasonic treatment, and filtering and separating to obtain a supernatant and a solid separator;

[0050] (6) subjecting the solid isolate obtained in step (5) to low-temperature drying to obtain a dry solid isolate; adding the dry solid isolate to an 80% ethanol solution, heating and refluxing for extraction for 1 hour, and obtaining an extract; the low-temperature drying temperature is 30° C., and the drying time is 6 hours;

[0051] (7) Mixing the supernatant obtained in step (5) and the extract obtained in step (6) to obtain a mixed extract, and concentrating the mixed extract by rotary evaporation to obtain a concentrated solution, that is, a multi-effect extract.

[0052] Example 4

[0053] A preparation process of angelica extract pills, characterized by comprising the following specific steps:

[0054] (1) washing and removing impurities from the angelica sinensis, and then drying the angelica sinensis to obtain pretreated angelica sinensis;

[0055] (2) spraying the pretreated angelica with deionized water to maintain the moisture content of the angelica at 80%, thereby obtaining a moistened angelica;

[0056] (3) The wetted angelica is subjected to freezing treatment at a temperature of -20°C, so that the wetted angelica can be completely frozen inside. After standing for a period of time, the angelica is subjected to thawing treatment, and the ice inside the angelica is completely melted. The freezing treatment time is 30 minutes, and the angelica is allowed to stand for 0.5 hours after freezing.

[0057] (4) coarsely crushing the angelica obtained in step (3) to obtain angelica fragments;

[0058] (5) preparing an ultrasonic treatment liquid, mixing water and ethanol in a volume ratio of 3:2 to obtain an ultrasonic treatment liquid, immersing the Angelica sinensis fragments obtained in step (4) in the ultrasonic treatment liquid at a solid-liquid ratio of 1:30, performing ultrasonic treatment, and filtering and separating to obtain a supernatant and a solid separator;

[0059] (6) subjecting the solid isolate obtained in step (5) to low-temperature drying to obtain a dry solid isolate; adding the dry solid isolate to a 70% ethanol solution, heating and refluxing for extraction for 1 hour, and obtaining an extract; the low-temperature drying temperature is 25° C., and the drying time is 6 hours;

[0060] (7) Mixing the supernatant obtained in step (5) and the extract obtained in step (6) to obtain a mixed extract, and concentrating the mixed extract by rotary evaporation to obtain a concentrated solution, that is, a multi-effect extract.

[0061] Comparative Example 1

[0062] A preparation process of angelica extract pills, characterized by comprising the following specific steps:

[0063] (1) washing and removing impurities from the angelica sinensis, and then drying the angelica sinensis to obtain pretreated angelica sinensis;

[0064] (2) coarsely crushing the angelica obtained in step (1) to obtain angelica fragments;

[0065] (3) preparing an ultrasonic treatment solution, which is obtained by mixing water and ethanol in a volume ratio of 3:1, immersing the Angelica sinensis fragments obtained in step (2) in the ultrasonic treatment solution at a solid-liquid ratio of 1:25, performing ultrasonic treatment, and filtering and separating to obtain a supernatant and a solid separator; the supernatant is reserved for later use.

[0066] (4) drying the solid isolate obtained in step (3) to obtain a dry solid isolate; adding the dry solid isolate to a 60% ethanol solution, heating and refluxing for extraction for 2 hours to obtain an extract;

[0067] (5) Mixing the supernatant obtained in step (3) and the extract obtained in step (4) to obtain a mixed extract, and concentrating the mixed extract by rotary evaporation to obtain a concentrated solution, that is, a multi-effect extract.

[0068] Comparative Example 2

[0069] A preparation process of angelica extract pills, characterized by comprising the following specific steps:

[0070] (1) washing and removing impurities from the angelica sinensis, and then drying the angelica sinensis to obtain pretreated angelica sinensis;

[0071] (2) spraying the pretreated angelica with deionized water to maintain the moisture content of the angelica at 70%, thereby obtaining a moistened angelica;

[0072] (3) The wetted angelica is subjected to freezing treatment, wherein the freezing treatment temperature is -15°C to -25°C, so that the inside of the wetted angelica can be completely frozen and frozen. After standing for a period of time, the angelica is subjected to a thawing treatment, and the ice inside the angelica is completely melted.

[0073] (4) coarsely crushing the angelica obtained in step (3) to obtain angelica fragments;

[0074] (5) Add the Angelica fragments obtained in step (4) to a 70% ethanol solution for heating and reflux extraction to obtain an extract, which is a multi-effect extract.

[0075] By improving the implementation method, the present invention increases the retention of phthalides, polysaccharides, ferulic acid and amino acids in angelica by more than 10% compared with the extraction method of the comparative example, so that volatile oil, polysaccharides, organic acids and amino acids are retained in multiple ways.

[0076] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine combination preparation, characterized in that: The invention comprises the following several kinds of traditional Chinese medicine pills, which are senna leaf extract pills, oriental rhizome extract pills, tuckahoe extract pills, cassia seed extract pills, angelica extract pills, cinnamon extract pills and lavender extract pills.

2. A preparation process for angelica extract pills, characterized in that: The specific steps include: (1) washing and removing impurities from the angelica sinensis, and then drying the angelica sinensis to obtain pretreated angelica sinensis; (2) spraying the pretreated angelica with deionized water to maintain the moisture content of the angelica at 60%-80%, thereby obtaining a moistened angelica; (3) The wetted angelica is subjected to freezing treatment, wherein the freezing treatment temperature is -15°C to -25°C, so that the inside of the wetted angelica can be completely frozen and frozen. After standing for a period of time, the angelica is subjected to a thawing treatment, and the ice inside the angelica is completely melted. (4) coarsely crushing the angelica obtained in step (3) to obtain angelica fragments; (5) preparing an ultrasonic treatment liquid, mixing water and ethanol in a volume ratio of 3:1-2 to obtain an ultrasonic treatment liquid, immersing the Angelica sinensis fragments obtained in step (4) in the ultrasonic treatment liquid at a solid-liquid ratio of 1:25-30, performing ultrasonic treatment, and filtering and separating to obtain a supernatant and a solid separator; (6) subjecting the solid isolate obtained in step (5) to low-temperature drying to obtain a dry solid isolate; adding the dry solid isolate to a 60%-80% ethanol solution, heating and refluxing for extraction for 0.5-1 h to obtain an extract; (7) Mixing the supernatant obtained in step (5) and the extract obtained in step (6) to obtain a mixed extract, and concentrating the mixed extract by rotary evaporation to obtain a concentrated solution, that is, a multi-effect extract; adding the multi-effect extract to auxiliary materials to obtain angelica extract pills.

3. The preparation process of the multi-effect angelica extract according to claim 2, characterized in that: In step (1), the angelica is removed from the impurities and cleaned by placing the angelica in a soaking box for washing and soaking, and then taken out and dried to obtain the pretreated angelica.

4. The preparation process of the multi-effect angelica extract according to claim 2, characterized in that: In step (2), the moisture content of the angelica is first measured, and the angelica is sprayed according to the measured moisture content.

5. The preparation process of the multi-effect angelica extract according to claim 2, characterized in that: The freezing treatment time in step (3) is 20-30 minutes, and the product is allowed to stand for 0.5-1 hour after freezing.

6. The preparation process of the multi-effect angelica extract according to claim 2, characterized in that: In step (4), a grinder is used to coarsely grind the angelica into pieces with a length of 3 mm to 5 mm.

7. The preparation process of the multi-effect angelica extract according to claim 2, characterized in that: In step (5), the ratio of water to ethanol is 3:1, the ultrasonic treatment time is 20-30 minutes, and the solid-liquid ratio is 1:25, preferably 1:

30.

8. The preparation process of the multi-effect angelica extract according to claim 2, characterized in that: In step (6), the temperature of low-temperature drying is 25-40° C., and the drying time is 4-6 hours; the concentration of the ethanol solution used is 70%, and the heating reflux time is 40 minutes.