Health-care traditional Chinese medicine foot bath bag and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicine health-care products, and particularly relates to a health-care traditional Chinese medicine foot bath bag and a preparation method thereof.The traditional Chinese medicine foot bath bag comprises an enzymolysis extract, a volatile oil clathrate compound, slow-release disintegrating particles and non-woven fabric, the enzymolysis extract is prepared from traditional Chinese medicine rich in flavonoid and alkaloid through an enzymolysis technology, and the extraction efficiency and the utilization rate are improved; the volatile oil clathrate compound is prepared by a supercritical CO2 extraction method and an embedding technology according to the characteristic that traditional Chinese medicines are rich in volatile oil, has stability and permeation promotion effects, and has the effects of promoting blood circulation to remove blood stasis, dredging channels and activating collaterals, warming yang and dispelling cold and the like; the sustained-release disintegration particles are prepared by a modern granulation technology, and the added disintegration promoting agent can generate an effervescent effect, so that active ingredients in the traditional Chinese medicine foot bath bag can be dissolved out more easily and can be absorbed by a human body; all the components interact, so that the sleep quality and the skin state are improved, and meanwhile, the gout can be effectively prevented and relieved.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine health products, and particularly relates to a health-care traditional Chinese medicine foot bath bag and a preparation method thereof. Technical Background

[0002] As a traditional external treatment method of Chinese medicine, foot bath has a history of thousands of years. It is a health care method that achieves multiple functions such as promoting blood circulation, dredging meridians, and eliminating toxins by soaking feet in hot water and combining the effects of Chinese herbal medicine. In recent years, with the increase in people's demand for health and wellness, the foot bath product market has developed rapidly, especially foot bath bags containing Chinese herbal ingredients, which are favored by consumers due to their convenience and versatility. From the perspective of traditional Chinese medicine, the foot is considered to be the "second heart of the human body". Many meridians of the human body originate or end in the feet. Foot bath can stimulate acupuncture points and regulate meridians to achieve the effects of relieving fatigue, improving sleep, and promoting metabolism. From the perspective of modern medicine, foot bathing can dilate capillaries, accelerate blood circulation, relax nerves and muscles, and at the same time, combined with the penetration of drugs, it can achieve auxiliary absorption of drug efficacy.

[0003] The traditional Chinese medicine foot bath bags currently on the market are usually directly mixed with Chinese herbal powder or granules, and the active ingredients are released by soaking in hot water. However, this method has problems such as uneven ingredient release, low utilization rate of active ingredients and insufficient user experience. Therefore, how to combine the medicinal properties of the traditional Chinese medicine foot bath bag with user needs to achieve efficient release of active ingredients is a technical problem that needs to be solved urgently. Summary of the invention

[0004] In view of the above situation, the present invention provides a health-care Chinese medicine foot bath bag and a preparation method thereof. According to the characteristics of Chinese medicine and the main active ingredients, isatis indigotica, perilla leaf, kudzu root, angelica pubescens, bupleurum, betel nut, rhubarb, camphor fruit, scutellaria, white peony root, anemarrhena, magnolia bark, platycodon, raw licorice, scutellaria baicalensis, coptis chinensis, loblolly, peach kernel, safflower, calamus, reed root, fructus aurantii, hawthorn, forsythia suspensa, chicken gizzard lining, white mustard seed, fennel, cinnamon bark, star anise, ebony, gypsum, ligusticum chuanxiong, sophora flavescens, three needles, ephedra, knotweed, cassia twig, thatch root and almond are processed, and then enzymatic extracts, volatile oil inclusion compounds and sustained-release disintegrating particles are made using functional materials. As the temperature changes, the active ingredients in each group are released in stages. When the temperature is high, the volatile oil in the volatile oil inclusion complex is released first, dilating the skin pores, dredging the meridians and activating blood circulation, and invigorating the spleen and stomach; as the soaking time increases, the protein peptides, vitamins and unsaturated fatty acids in the sustained-release disintegrating granules nourish the skin, relieve inflammation, promote metabolism, etc. At the same time, they promote the synergistic release of components such as polysaccharides, polyphenols, saponins and flavonoids in the enzymatic extract, effectively enhance the excretion of uric acid, inhibit the infiltration of inflammatory cells, etc., and have the effect of relieving joint swelling.

[0005] To achieve the above purpose, the technical solution adopted by the present invention is as follows: The invention provides a health-care traditional Chinese medicine foot bath bag, which comprises an enzymatic hydrolysis extract, a volatile oil inclusion compound, slow-release disintegrating particles and a non-woven fabric.

[0006] Furthermore, the enzymatic extract is prepared from the following raw materials: isatis indigotica, scutellaria baicalensis, coptis chinensis, sophora flavescens, forsythia suspensa, three needles, knotweed, ligusticum chuanxiong, bamboo leaf, magnolia bark, gypsum, bupleurum, rhubarb, white mustard seeds, kudzu root, complex enzyme, carbomer 940 and purified water, and the mass ratio of isatis indigotica, scutellaria baicalensis, coptis chinensis, sophora flavescens, forsythia suspensa, three needles, knotweed, ligusticum chuanxiong, bamboo leaf, magnolia bark, gypsum, bupleurum, rhubarb, white mustard seeds and kudzu root is 10-15:20-22:20:20-24:15-18:10-15:20-25:25:10-13:18-20:10-12:12-15:10:12:10.

[0007] Furthermore, the complex enzyme consists of cellulase, pectinase and amylase in a mass ratio of 1:2:1.

[0008] Furthermore, the volatile oil inclusion compound is prepared from the following raw materials: perilla leaf, angelica dahurica, safflower, fennel, cinnamon bark, star anise, calamus, fructus aurantii, root of grass grass, camphor tree fruit, β-cyclodextrin, anhydrous ethanol and purified water, and the mass ratio of the perilla leaf, angelica dahurica, safflower, ligusticum chuanxiong, cinnamon bark, star anise, calamus, fructus aurantii, magnolia bark and camphor tree fruit is 12-15:10-13:9-12:10:10:8-10:8-10:6:6:6:5-8.

[0009] Furthermore, the sustained-release disintegrating granules are prepared from the following raw materials: ephedra, scutellaria baicalensis, raw licorice, platycodon, cinnamon twig, white peony root, anemarrhena asphodeloides, reed root, peach kernel, ebony, chicken gizzard lining, hawthorn, almond, betel nut, low-substituted hydroxypropyl cellulose and sodium bicarbonate, with a mass ratio of 13:12-13:11-13:12:12:10-12:10-12:12-15:10:8-11:10:8-10:6-10:3-5:10:2.

[0010] Furthermore, the mass ratio of the enzymatic extract, the volatile oil inclusion compound, and the sustained-release disintegrating granules is 8-10:5-9:20-30.

[0011] The preparation method of the enzymatic extract comprises the following steps: A1: Weigh Folium Isatidis, Radix Scutellariae, Rhizoma Coptidis, Radix Sophorae Flavescentis, Rhizoma Forsythiae, Rhizoma Tripterygii, Polygonum Cuspidati, Rhizoma Chuanxiong, Rhizoma Lophatheri, Cortex Magnoliae Officinalis, Gypsum, Radix Bupleuri, Rhubarb, Semen Sinapis and Radix Puerariae in a mass ratio of 10-15:20-22:20:20-24:15-18:10-15:20-25:25:10-13:18-20:10-12:12-15:10:12:10, grind them in a grinder and pass through a 20-mesh sieve to obtain Chinese medicine powder I; A2: Add 6 times the weight of purified water to the Chinese medicine powder I obtained in step A1, place in a constant temperature water bath, heat to 80°C and soak for 30 min, then cool to 40°C, adjust the pH of the soaking solution to 5.0-5.2 with 40% citric acid aqueous solution, weigh the composite enzyme according to the mass ratio of purified water to composite enzyme of 10:0.1, add it to the soaking solution, stir evenly, and perform enzymolysis for 40 min to obtain an enzymolysis mixture; A3: The enzymatic hydrolysis mixture obtained in step A2 was heated to 80°C for enzyme inactivation, decocted for 40 min, filtered with filter cloth to obtain drug residues and enzymatic hydrolysis extract, and the same amount of purified water as that in the first extraction was added to the drug residues for a second decoction for 30 min. The two decoctions were combined, centrifuged at 5000 rpm for 10 min, and the supernatant was obtained by transfer; A4: The supernatant obtained in step A3 is filtered through a 0.45 μm water filter membrane and then ultrafiltered using a polypropylene hollow fiber column to remove macromolecular impurities to obtain an enzymatic ultrafiltrate; A5: Weigh Carbomer 940 and add it to the enzymatic ultrafiltrate obtained in step A4, the mass volume ratio of Carbomer 940 to the enzymatic ultrafiltrate is 0.5-2 g: 100 mL, place it in a constant temperature magnetic stirrer and stir to dissolve, the speed is 80 rpm, the stirring time is 20 min, and the enzymatic extract gel is obtained. The enzymatic extract gel is frozen in a -80°C refrigerator for 24 h, and freeze-dried to obtain the enzymatic extract.

[0012] The preparation method of the volatile oil inclusion compound comprises the following steps: B1: Weigh perilla leaf, angelica dahurica, safflower, fennel, cinnamon bark, star anise, calamus, fructus aurantii, root of grass grass and camphor fruit in a mass ratio of 12-15:10-13:9-12:10:10:8-10:8-10:6:6:6:5-8, grind with a grinder and pass through a 40-mesh sieve to obtain Chinese medicine powder II; B2: Extract the volatile oil of traditional Chinese medicine by supercritical CO2 extraction method. Transfer the traditional Chinese medicine powder II obtained in step B1 to the supercritical CO2 extraction equipment, the extraction temperature is 40°C, the extraction pressure is 30 MPa, the pressure of separation kettle I is 8 MPa, the pressure of separation kettle II is 6 MPa, the extraction time is 2 h, and the volatile oil of traditional Chinese medicine is obtained; B3: The volatile oil of traditional Chinese medicine obtained in step B2 was dissolved in anhydrous ethanol of equal mass to obtain a volatile oil solution, β-cyclodextrin was weighed according to a mass ratio of volatile oil solution to β-cyclodextrin of 1:4, purified water was added to β-cyclodextrin according to a mass volume ratio of 1 g:8 mL, and stirred in a constant temperature magnetic stirrer for 10 min at a stirring temperature of 40°C and a rotation speed of 300 rpm to obtain a β-cyclodextrin solution; B4: The volatile oil solution obtained in step B3 is added to the β-cyclodextrin solution at a rate of 2-3 drops / s for inclusion. After the addition is complete, the inclusion is continued for 2 h. After cooling to room temperature, the volatile oil inclusion compound is refrigerated in a refrigerator at 4°C for 24 h to obtain a crude volatile oil inclusion compound. B5: The crude volatile oil inclusion compound obtained in step B4 was filtered through a Buchner funnel to obtain a filter residue, which was first washed with purified water for 3 times (10 mL / time), then washed with anhydrous ethanol for 3 times (10 mL / time), and dried in an oven at 45°C for 4 h to obtain a volatile oil inclusion compound.

[0013] The method for preparing the sustained-release disintegrating granules comprises the following steps: C1: Weigh ephedra, scutellaria baicalensis, raw liquorice, platycodon, cassia twig, white peony root, anemarrhena, reed root, peach kernel, ebony, chicken gizzard lining, hawthorn, almond, betel nut, low-substituted hydroxypropyl cellulose and sodium bicarbonate in a mass ratio of 13:12-13:11-13:12:12:10-12:10-12:12-15:10:8-11:10:8-10:6-10:3-5:10:2; C2: Crush the ephedra, scutellaria baicalensis, raw liquorice, platycodon, cassia twig, white peony root, rhizoma anemarrhenae, rhizoma rehmanniae, persica, ebony, chicken gizzard lining, hawthorn, apricot kernel, and betel nut weighed in step C1 with a high-speed grinder, and pass through a 20-mesh sieve to obtain Chinese medicine powder III. Mix the Chinese medicine powder III, low-substituted hydroxypropyl cellulose, and sodium bicarbonate with a mixer for 10 min at a spindle speed of 15 r / min to obtain an intermediate; C3: The intermediate obtained in step C2 was granulated using a dry granulator, with a feed speed of 50-60 rpm, a roller speed of 10-12 rpm, a granulation speed of 120-130 rpm, a molding pressure of 160 bar, and a particle size of 2.0-2.5 mm to obtain sustained-release disintegrating granules.

[0014] The present invention also provides a method for preparing a health-care Chinese medicine foot bath bag, which specifically comprises the following steps: Step 1: Weigh the enzymatic extract, volatile oil inclusion compound and sustained-release disintegrating granules in a mass ratio of 8-10:5-9:20-30, mix the enzymatic extract and sustained-release disintegrating granules in a mixer for 5 min at a main shaft speed of 15 r / min to obtain a primary mixture; Step 2: heating the primary mixture obtained in step 1 for 10 min at a flow rate of 100-150 mL / min in an argon atmosphere at a temperature of 40-45° C., and cooling to room temperature to obtain a gelled primary mixture; Step 3: Mix the volatile oil inclusion compound weighed in step 1 with the gelled primary mixture obtained in step 2, with a mixing time of 5 min and a spindle speed of 15 r / min to obtain a total mixture; Step 4: The total mixture obtained in step 3 is packaged with non-woven fabric to obtain a health-care Chinese medicine foot bath bag.

[0015] The beneficial effects achieved by the present invention are as follows: The health-care Chinese medicine foot bath bag prepared by the present invention is grouped according to the characteristics of Chinese medicine, and the utilization rate of active ingredients is effectively improved after being treated by different methods. The volatile oil components in Chinese medicines such as perilla leaf, angelica dahurica, safflower and camphor fruit are extracted by supercritical CO2 extraction, and the volatile oil components are embedded in β-cyclodextrin by thermosensitive embedding technology. The active ingredients are accurately released at the foot bath temperature (40-50°C), which effectively avoids the volatilization loss of active ingredients and significantly improves the absorption efficiency. It has the effects of promoting blood circulation and removing blood stasis, dredging meridians and activating collaterals, warming yang and removing cold, and is beneficial to promoting the transdermal absorption of other active ingredients. After enzymatic hydrolysis of Chinese medicines such as Polygonum cuspidatum, Ligusticum chuanxiong, Magnolia officinalis and Scutellaria baicalensis, the extraction efficiency of components such as polysaccharides, polyphenols and saponins is increased, and ultrafiltration treatment improves the purity of the extract, which effectively solves the problem of traditional Chinese medicine foot bath. The problem of low absorption and utilization rate of effective ingredients in bath bags is solved, and the skin is more easily absorbed by the active ingredients in the enzymatic extract under the pre-action of volatile oils, which can effectively promote the excretion of uric acid in the human body, relieve joint pain, and prevent or improve gout; the Chinese medicine sustained-release disintegrating granules prepared by adding low-substituted hydroxypropyl cellulose and sodium bicarbonate can continuously release active ingredients such as peptides and vitamins during the foot bath, play an antioxidant and nutrient supply role, and also avoid the problem of sudden release of ingredients in traditional foot baths and untimely absorption leading to inactivation. In addition, sodium bicarbonate produces a similar "effervescence" effect under the action of acidic substances in the Chinese medicine granules. The effective ingredients of the disintegrated Chinese medicine powder are more easily dissolved and absorbed through the skin under the action of gas. At the same time, it has a "timing" function to remind users of the foot bath time.

[0016] Compared with the prior art, the health-care Chinese medicine foot bath bag provided by the present invention not only realizes the efficient extraction and transdermal absorption of the active ingredients of Chinese medicine, but also optimizes the synergistic enhancement between different components, can effectively improve sleep quality and prevent and relieve gout, and has extremely strong market application prospects and promotion value. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 This is a preparation flow chart of a health-care Chinese medicine foot bath bag of the present invention; Figure 2 The in vitro cumulative skin permeability of Baicalin in the traditional Chinese medicine foot bath package prepared in Example 1-3 and Comparative Example 1-3; Figure 3 This is a graph showing the skin water loss results of the Chinese medicine foot bath packs prepared in Examples 1-3 and Comparative Examples 1-3.

[0018] The accompanying drawings are used to provide further understanding of the present invention and constitute a part of the specification. They are used to explain the present invention together with the embodiments of the present invention and do not constitute a limitation of the present invention. DETAILED DESCRIPTION

[0019] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments; based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0020] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as those familiar to those skilled in the art. In addition, any methods and materials similar or equivalent to those described herein may be applied to the present invention. The preferred implementation methods and materials described herein are for demonstration purposes only and are not intended to limit the content of this application.

[0021] The preparation process in the following examples is referred to Figure 1 Unless otherwise specified, all methods are conventional; the materials used in the following embodiments, unless otherwise specified, are new materials purchased from the market.

[0022] Example 1: This example provides a health-care Chinese medicine foot bath bag, comprising an enzymatic extract, a volatile oil inclusion compound, a sustained-release disintegrating granule and a non-woven fabric, wherein the mass ratio of the enzymatic extract, the volatile oil inclusion compound and the sustained-release disintegrating granule is 8:5:20; The preparation method of the enzymatic extract comprises the following steps: A1: Weigh isatis indigotica, scutellaria baicalensis, coptis root, sophora flavescens, forsythia suspensa, trifoliate needle, knotweed, ligusticum chuanxiong, lophatherum gracile, magnolia officinalis, gypsum, bupleurum, rhubarb, mustard seed and kudzu root in a mass ratio of 15:20:20:20:18:15:20:25:10:18:10:12:10, grind with a grinder and pass through a 20-mesh sieve to obtain Chinese medicine powder I; A2: Add 6 times the weight of purified water to the Chinese medicine powder I obtained in step A1, place in a constant temperature water bath, heat to 80°C and soak for 30 min, then cool to 40°C, adjust the pH of the soaking solution to 5.0-5.2 with 40% citric acid aqueous solution, weigh the composite enzyme according to the mass ratio of purified water to composite enzyme of 10:0.1, add it to the soaking solution, stir evenly, and perform enzymolysis for 40 min to obtain an enzymolysis mixture; A3: The enzymatic hydrolysis mixture obtained in step A2 was heated to 80°C for enzyme inactivation, decocted for 40 min, filtered with filter cloth to obtain drug residues and enzymatic hydrolysis extract, and the same amount of purified water as that in the first extraction was added to the drug residues for a second decoction for 30 min. The two decoctions were combined, centrifuged at 5000 rpm for 10 min, and the supernatant was obtained by transfer; A4: The supernatant obtained in step A3 is filtered through a 0.45 μm water filter membrane and then ultrafiltered using a polypropylene hollow fiber column to remove macromolecular impurities to obtain an enzymatic ultrafiltrate; A5: Weigh Carbomer 940 and add it to the enzymatic ultrafiltrate obtained in step A4, the mass volume ratio of Carbomer 940 to the enzymatic ultrafiltrate is 1 g: 100 mL, place it in a constant temperature magnetic stirrer and stir to dissolve, the speed is 80 rpm, the stirring time is 20 min, and the enzymatic extract gel is obtained. The enzymatic extract gel is frozen in a -80°C refrigerator for 24 h and freeze-dried to obtain the enzymatic extract.

[0023] The preparation method of the volatile oil inclusion compound comprises the following steps: B1: Weigh perilla leaf, angelica dahurica, safflower, fennel, cinnamon bark, star anise, calamus, fructus aurantii, root of grass grass and camphor fruit in a mass ratio of 15:10:10:10:10:10:8:6:6:6:6, grind them in a grinder and pass through a 40-mesh sieve to obtain Chinese medicine powder II; B2: Extract the volatile oil of traditional Chinese medicine by supercritical CO2 extraction method. Transfer the traditional Chinese medicine powder II obtained in step B1 to the supercritical CO2 extraction equipment, the extraction temperature is 40°C, the extraction pressure is 30 MPa, the pressure of separation kettle I is 8 MPa, the pressure of separation kettle II is 6 MPa, the extraction time is 2 h, and the volatile oil of traditional Chinese medicine is obtained; B3: The volatile oil of traditional Chinese medicine obtained in step B2 was dissolved in anhydrous ethanol of equal mass to obtain a volatile oil solution, β-cyclodextrin was weighed according to a mass ratio of volatile oil solution to β-cyclodextrin of 1:4, purified water was added to β-cyclodextrin according to a mass volume ratio of 1 g:8 mL, and stirred in a constant temperature magnetic stirrer for 10 min at a stirring temperature of 40°C and a rotation speed of 300 rpm to obtain a β-cyclodextrin solution; B4: The volatile oil solution obtained in step B3 is added to the β-cyclodextrin solution at a rate of 2-3 drops / s for inclusion. After the addition is complete, the inclusion is continued for 2 h. After cooling to room temperature, the volatile oil inclusion compound is refrigerated in a refrigerator at 4°C for 24 h to obtain a crude volatile oil inclusion compound. B5: The crude volatile oil inclusion compound obtained in step B4 was filtered through a Buchner funnel to obtain a filter residue, which was first washed with purified water for 3 times (10 mL / time), then washed with anhydrous ethanol for 3 times (10 mL / time), and dried in an oven at 45°C for 4 h to obtain a volatile oil inclusion compound.

[0024] The method for preparing the sustained-release disintegrating granules comprises the following steps: C1: Ephedra, Semen Lemongrass, Licorice, Platycodon, Cinnamon Twig, White Peony Root, Rhizoma Anemarrhenae, Rhizoma Phragmites, Semen Persicae, Prunus Mume, Gallus Officinalis, Hawthorn, Apricot, Areca Nut, Low-substituted Hydroxypropylcellulose and Sodium Bicarbonate were weighed in a mass ratio of 13:13:13:12:12:10:10:12:10:10:10:8:8:5:10:2; C2: Crush the ephedra, scutellaria baicalensis, raw liquorice, platycodon, cassia twig, white peony root, rhizoma anemarrhenae, rhizoma rehmanniae, persica, ebony, chicken gizzard lining, hawthorn, apricot kernel, and betel nut weighed in step C1 with a high-speed grinder, and pass through a 20-mesh sieve to obtain Chinese medicine powder III. Mix the Chinese medicine powder III, low-substituted hydroxypropyl cellulose, and sodium bicarbonate with a mixer for 10 min at a spindle speed of 15 r / min to obtain an intermediate; C3: The intermediate obtained in step C2 was granulated using a dry granulator with a feed speed of 50 rpm, a roller speed of 10 rpm, a granulation speed of 120 rpm, a molding pressure of 160 bar, and a particle size of 2.0-2.5 mm to obtain sustained-release disintegrating granules.

[0025] This embodiment also provides a method for preparing a health-care Chinese medicine foot bath bag, which specifically comprises the following steps: Step 1: Weigh the enzymatic extract, volatile oil inclusion compound and sustained-release disintegrating granules in a mass ratio of 8:5:20, mix the enzymatic extract and sustained-release disintegrating granules in a mixer for 5 min at a main shaft speed of 15 r / min to obtain a primary mixture; Step 2: heating the primary mixture obtained in step 1 for 10 min at a flow rate of 120 mL / min in an argon atmosphere at a temperature of 45° C., and cooling to room temperature to obtain a gelled primary mixture; Step 3: Mix the volatile oil inclusion compound weighed in step 1 with the gelled primary mixture obtained in step 2, with a mixing time of 5 min and a spindle speed of 15 r / min to obtain a total mixture; Step 4: The total mixture obtained in step 3 is packaged with non-woven fabric to obtain a health-care Chinese medicine foot bath bag.

[0026] Example 2: This example provides a health-care Chinese medicine foot bath bag, comprising an enzymatic extract, a volatile oil inclusion compound, sustained-release disintegrating particles and a non-woven fabric, wherein the mass ratio of the enzymatic extract, the volatile oil inclusion compound and the sustained-release disintegrating particles is 9:8:25; The preparation method of the enzymatic extract comprises the following steps: A1: Weigh isatis indigotica, scutellaria baicalensis, coptis root, sophora flavescens, forsythia suspensa, trifoliate needle, knotweed, ligusticum chuanxiong, lophatherum gracile, magnolia officinalis, gypsum, bupleurum, rhubarb, mustard seed and kudzu root in a mass ratio of 15:20:20:20:18:15:20:25:10:18:10:12:10, grind with a grinder and pass through a 20-mesh sieve to obtain Chinese medicine powder I; A2: Add 6 times the weight of purified water to the Chinese medicine powder I obtained in step A1, place in a constant temperature water bath, heat to 80°C and soak for 30 min, then cool to 40°C, adjust the pH of the soaking solution to 5.0-5.2 with 40% citric acid aqueous solution, weigh the composite enzyme according to the mass ratio of purified water to composite enzyme of 10:0.1, add it to the soaking solution, stir evenly, and perform enzymolysis for 40 min to obtain an enzymolysis mixture; A3: The enzymatic hydrolysis mixture obtained in step A2 was heated to 80°C for enzyme inactivation, decocted for 40 min, filtered with filter cloth to obtain drug residues and enzymatic hydrolysis extract, and the same amount of purified water as that in the first extraction was added to the drug residues for a second decoction for 30 min. The two decoctions were combined, centrifuged at 5000 rpm for 10 min, and the supernatant was obtained by transfer; A4: The supernatant obtained in step A3 is filtered through a 0.45 μm water filter membrane and then ultrafiltered using a polypropylene hollow fiber column to remove macromolecular impurities to obtain an enzymatic ultrafiltrate; A5: Weigh Carbomer 940 and add it to the enzymatic ultrafiltrate obtained in step A4, the mass volume ratio of Carbomer 940 to the enzymatic ultrafiltrate is 1 g: 100 mL, place it in a constant temperature magnetic stirrer and stir to dissolve, the speed is 80 rpm, the stirring time is 20 min, and the enzymatic extract gel is obtained. The enzymatic extract gel is frozen in a -80°C refrigerator for 24 h and freeze-dried to obtain the enzymatic extract.

[0027] The preparation method of the volatile oil inclusion compound comprises the following steps: B1: Weigh perilla leaf, angelica dahurica, safflower, fennel, cinnamon bark, star anise, calamus, fructus aurantii, root of grass grass and camphor fruit in a mass ratio of 15:10:10:10:10:10:8:6:6:6:6, grind them in a grinder and pass through a 40-mesh sieve to obtain Chinese medicine powder II; B2: Extract the volatile oil of traditional Chinese medicine by supercritical CO2 extraction method. Transfer the traditional Chinese medicine powder II obtained in step B1 to the supercritical CO2 extraction equipment, the extraction temperature is 40°C, the extraction pressure is 30 MPa, the pressure of separation kettle I is 8 MPa, the pressure of separation kettle II is 6 MPa, the extraction time is 2 h, and the volatile oil of traditional Chinese medicine is obtained; B3: The volatile oil of traditional Chinese medicine obtained in step B2 was dissolved in anhydrous ethanol of equal mass to obtain a volatile oil solution, β-cyclodextrin was weighed according to a mass ratio of volatile oil solution to β-cyclodextrin of 1:4, purified water was added to β-cyclodextrin according to a mass volume ratio of 1 g:8 mL, and stirred in a constant temperature magnetic stirrer for 10 min at a stirring temperature of 40°C and a rotation speed of 300 rpm to obtain a β-cyclodextrin solution; B4: The volatile oil solution obtained in step B3 is added to the β-cyclodextrin solution at a rate of 2-3 drops / s for inclusion. After the addition is complete, the inclusion is continued for 2 h. After cooling to room temperature, the volatile oil inclusion compound is refrigerated in a refrigerator at 4°C for 24 h to obtain a crude volatile oil inclusion compound. B5: The crude volatile oil inclusion compound obtained in step B4 was filtered through a Buchner funnel to obtain a filter residue, which was first washed with purified water for 3 times (10 mL / time), then washed with anhydrous ethanol for 3 times (10 mL / time), and dried in an oven at 45°C for 4 h to obtain a volatile oil inclusion compound.

[0028] The method for preparing the sustained-release disintegrating granules comprises the following steps: C1: Ephedra, Semen Lemongrass, Licorice, Platycodon, Cinnamon Twig, White Peony Root, Rhizoma Anemarrhenae, Rhizoma Phragmites, Semen Persicae, Prunus Mume, Gallus Officinalis, Hawthorn, Apricot, Areca Nut, Low-substituted Hydroxypropylcellulose and Sodium Bicarbonate were weighed in a mass ratio of 13:13:13:12:12:10:10:12:10:10:10:8:8:5:10:2; C2: Crush the ephedra, scutellaria baicalensis, raw liquorice, platycodon, cassia twig, white peony root, rhizoma anemarrhenae, rhizoma rehmanniae, persica, ebony, chicken gizzard lining, hawthorn, apricot kernel, and betel nut weighed in step C1 with a high-speed grinder, and pass through a 20-mesh sieve to obtain Chinese medicine powder III. Mix the Chinese medicine powder III, low-substituted hydroxypropyl cellulose, and sodium bicarbonate with a mixer for 10 min at a spindle speed of 15 r / min to obtain an intermediate; C3: The intermediate obtained in step C2 was granulated using a dry granulator with a feed speed of 50 rpm, a roller speed of 10 rpm, a granulation speed of 120 rpm, a molding pressure of 160 bar, and a particle size of 2.0-2.5 mm to obtain sustained-release disintegrating granules.

[0029] This embodiment also provides a method for preparing a health-care Chinese medicine foot bath bag, which specifically comprises the following steps: Step 1: Weigh the enzymatic extract, volatile oil inclusion compound and sustained-release disintegrating granules in a mass ratio of 9:8:25, mix the enzymatic extract and sustained-release disintegrating granules in a mixer for 5 min at a main shaft speed of 15 r / min to obtain a primary mixture; Step 2: heating the primary mixture obtained in step 1 at a flow rate of 120 mL / min of argon atmosphere for 10 min at a heating temperature of 45° C., and cooling to room temperature to obtain a gelled primary mixture; Step 3: Mix the volatile oil inclusion compound weighed in step 1 with the gelled primary mixture obtained in step 2, with a mixing time of 5 min and a spindle speed of 15 r / min to obtain a total mixture; Step 4: The total mixture obtained in step 3 is packaged with non-woven fabric to obtain a health-care Chinese medicine foot bath bag.

[0030] Example 3: This example provides a health-care Chinese medicine foot bath bag, comprising an enzymatic extract, a volatile oil inclusion compound, a sustained-release disintegrating granule and a non-woven fabric, wherein the mass ratio of the enzymatic extract, the volatile oil inclusion compound and the sustained-release disintegrating granule is 10:9:30; The preparation method of the enzymatic extract comprises the following steps: A1: Weigh isatis indigotica, scutellaria baicalensis, coptis root, sophora flavescens, forsythia suspensa, trifoliate needle, knotweed, ligusticum chuanxiong, lophatherum gracile, magnolia officinalis, gypsum, bupleurum, rhubarb, mustard seed and kudzu root in a mass ratio of 15:20:20:20:18:15:20:25:10:18:10:12:10, grind with a grinder and pass through a 20-mesh sieve to obtain Chinese medicine powder I; A2: Add 6 times the weight of purified water to the Chinese medicine powder I obtained in step A1, place in a constant temperature water bath, heat to 80°C and soak for 30 min, then cool to 40°C, adjust the pH of the soaking solution to 5.0-5.2 with 40% citric acid aqueous solution, weigh the composite enzyme according to the mass ratio of purified water to composite enzyme of 10:0.1, add it to the soaking solution, stir evenly, and perform enzymolysis for 40 min to obtain an enzymolysis mixture; A3: The enzymatic hydrolysis mixture obtained in step A2 was heated to 80°C for enzyme inactivation, decocted for 40 min, filtered with filter cloth to obtain drug residues and enzymatic hydrolysis extract, and the same amount of purified water as that in the first extraction was added to the drug residues for a second decoction for 30 min. The two decoctions were combined, centrifuged at 5000 rpm for 10 min, and the supernatant was obtained by transfer; A4: The supernatant obtained in step A3 is filtered through a 0.45 μm water filter membrane and then ultrafiltered using a polypropylene hollow fiber column to remove macromolecular impurities to obtain an enzymatic ultrafiltrate; A5: Weigh Carbomer 940 and add it to the enzymatic ultrafiltrate obtained in step A4, the mass volume ratio of Carbomer 940 to the enzymatic ultrafiltrate is 1 g: 100 mL, place it in a constant temperature magnetic stirrer and stir to dissolve, the speed is 80 rpm, the stirring time is 20 min, and the enzymatic extract gel is obtained. The enzymatic extract gel is frozen in a -80°C refrigerator for 24 h and freeze-dried to obtain the enzymatic extract.

[0031] The preparation method of the volatile oil inclusion compound comprises the following steps: B1: Weigh perilla leaf, angelica dahurica, safflower, fennel, cinnamon bark, star anise, calamus, fructus aurantii, root of grass grass and camphor fruit in a mass ratio of 15:10:10:10:10:10:8:6:6:6:6, grind them in a grinder and pass through a 40-mesh sieve to obtain Chinese medicine powder II; B2: Extract the volatile oil of traditional Chinese medicine by supercritical CO2 extraction method. Transfer the traditional Chinese medicine powder II obtained in step B1 to the supercritical CO2 extraction equipment, the extraction temperature is 40°C, the extraction pressure is 30 MPa, the pressure of separation kettle I is 8 MPa, the pressure of separation kettle II is 6 MPa, the extraction time is 2 h, and the volatile oil of traditional Chinese medicine is obtained; B3: The volatile oil of the traditional Chinese medicine obtained in step B2 was dissolved in an equal mass of anhydrous ethanol to obtain a volatile oil solution, β-cyclodextrin was weighed according to a mass ratio of volatile oil solution to β-cyclodextrin of 1:4, purified water was added to β-cyclodextrin according to a mass volume ratio of 1 g:8 mL, and stirred in a constant temperature magnetic stirrer for 10 min at a stirring temperature of 40°C and a rotation speed of 300 rpm to obtain a β-cyclodextrin solution; B4: The volatile oil solution obtained in step B3 is added to the β-cyclodextrin solution at a rate of 2-3 drops / s for inclusion. After the addition is complete, the inclusion is continued for 2 h. After cooling to room temperature, the volatile oil inclusion compound is refrigerated in a refrigerator at 4°C for 24 h to obtain a crude volatile oil inclusion compound. B5: The crude volatile oil inclusion compound obtained in step B4 was filtered through a Buchner funnel to obtain a filter residue, which was first washed with purified water for 3 times (10 mL / time), then washed with anhydrous ethanol for 3 times (10 mL / time), and dried in an oven at 45°C for 4 h to obtain a volatile oil inclusion compound.

[0032] The method for preparing the sustained-release disintegrating granules comprises the following steps: C1: Ephedra, Semen Lemongrass, Licorice, Platycodon, Cinnamon Twig, White Peony Root, Rhizoma Anemarrhenae, Rhizoma Phragmites, Semen Persicae, Prunus Mume, Gallus Officinalis, Hawthorn, Apricot, Areca Nut, Low-substituted Hydroxypropylcellulose and Sodium Bicarbonate were weighed in a mass ratio of 13:13:13:12:12:10:10:12:10:10:10:8:8:5:10:2; C2: Crush the ephedra, scutellaria baicalensis, raw liquorice, platycodon, cassia twig, white peony root, rhizoma anemarrhenae, rhizoma rehmanniae, persica, ebony, chicken gizzard lining, hawthorn, apricot kernel, and betel nut weighed in step C1 with a high-speed grinder, and pass through a 20-mesh sieve to obtain Chinese medicine powder III. Mix the Chinese medicine powder III, low-substituted hydroxypropyl cellulose, and sodium bicarbonate with a mixer for 10 min at a spindle speed of 15 r / min to obtain an intermediate; C3: The intermediate obtained in step C2 was granulated using a dry granulator with a feed speed of 50 rpm, a roller speed of 10 rpm, a granulation speed of 120 rpm, a molding pressure of 160 bar, and a particle size of 2.0-2.5 mm to obtain sustained-release disintegrating granules.

[0033] This embodiment also provides a method for preparing a health-care Chinese medicine foot bath bag, which specifically comprises the following steps: Step 1: Weigh the enzymatic extract, volatile oil inclusion compound and sustained-release disintegrating granules in a mass ratio of 10:9:30, mix the enzymatic extract and sustained-release disintegrating granules in a mixer for 5 min at a main shaft speed of 15 r / min to obtain a primary mixture; Step 2: heating the primary mixture obtained in step 1 for 10 min at a flow rate of 120 mL / min in an argon atmosphere at a temperature of 45° C., and cooling to room temperature to obtain a gelled primary mixture; Step 3: Mix the volatile oil inclusion compound weighed in step 1 with the gelled primary mixture obtained in step 2, with a mixing time of 5 min and a spindle speed of 15 r / min to obtain a total mixture; Step 4: The total mixture obtained in step 3 is packaged with non-woven fabric to obtain a health-care Chinese medicine foot bath bag.

[0034] The difference between Comparative Example 1 and Example 1 is that no enzymatic extract is added, and the rest is the same as Example 1.

[0035] The difference between Comparative Example 2 and Example 1 is that no volatile oil inclusion compound is added, and the rest is the same as Example 1.

[0036] The difference between Comparative Example 3 and Example 1 is that no sustained-release disintegrating particles are added, and the rest is the same as Example 1.

[0037] Obviously, the above comparative examples and embodiments are only a part of comparative examples and embodiments of the present invention, and they and the comparative examples and embodiments based on such references are all within the scope of protection of the present invention.

[0038] In vitro permeation test The baicalin in the foot bath bag was used as the detection component index, and the HPLC (high performance liquid chromatography) quality standard was established by using the baicalin standard product. The mobile phase was acetonitrile-1% formic acid aqueous solution. The in vitro transdermal absorption experiment was carried out by using the modified Franz diffusion cell method. The abdominal skin of the ex vivo SD rat was taken, and the body hair, subcutaneous fat, capillaries and other tissues were removed. The skin was rinsed with physiological saline and fixed on the Franz diffusion cell with the stratum corneum facing up. The 20% ethanol PBS pre-ultrasonic degassed was used as the receiving solution. The temperature was 45°C. The heavy baicalin content of the soaking solution of the Chinese medicine foot bath bag in an isothermal and equal amount of immersion for 30 min was determined as the content detection endpoint. The Chinese medicine foot bath bags prepared in Examples 1-3 and Comparative Examples 1-3 were respectively added to the supply chamber. 0.3 mL of the receiving solution was taken at 2, 5, 10, 15, 20, and 30 min, respectively, and an equal amount of fresh blank receiving solution at the same temperature was supplemented. The receiving solution sample was heated at 12000 The supernatant was centrifuged at rpm for 10 min, and the content of baicalin was determined by HPLC. The cumulative permeability of baicalin at different time points was calculated, and the permeation curve was drawn. The results are shown in Figure 2 shown.

[0039] Investigation of skin water loss The water loss of the skin after the foot bath pack treatment was measured using a skin performance tester. After anesthetizing male SD rats, the abdominal hair was removed with a blade, washed with warm water, and naturally raised overnight. The abdominal skin of the rats was fixed upward, and the TEWL value of the selected skin area was measured as the initial value; the Chinese medicine foot bath packs prepared in Examples 1-3 and Comparative Examples 1-3 were taken and soaked in constant temperature 45°C purified water for 30 min, and 20 μL of the soaking liquid was taken and applied to one of the skins on the rat's abdomen for 30 min. The TEWL value of the skin after treatment was measured, and ΔTEWL=TEWL was calculated. 处理后 -TEWL 初始值 , with ΔTEWL value (g·m -2 ·h -1 ) represents the water loss of rat skin. The results are shown in Figure 3 .

[0040] Evaluation of pain index and TCM syndrome score 40 patients with chronic gout were selected as research subjects and randomly divided into 4 groups. The patients were treated with the Chinese medicine foot bath bags prepared in Example 1 and Comparative Examples 1-3 every day for 30 min. The pain of the patients was evaluated by the visual analogue scale (VAS). The patients scored between 0 and 10 points according to their tolerance to pain, with 0 for painlessness and 10 for severe pain. The TCM syndrome score was used to score the patients' joint pain, swelling, activity function, fatigue, abdominal distension and other symptoms. Each item was divided into four levels according to severity, namely, none, mild, moderate and severe, which were recorded as 0, 1, 2 and 3 points respectively. The syndrome score was reduced by ≥95%, which was cured; the syndrome score was reduced by ≥70%, which was effective; the syndrome score was reduced by ≥30%, which was effective; the syndrome score was reduced by <30%, which was invalid. The scores were expressed by the average value, and the results are shown in Table 1.

[0041] Table 1 Evaluation of the health-care effects of Chinese medicine foot bath bags

[0042] The results in Table 1 show that the Chinese medicine foot bath bag prepared in Example 1 has the effects of relieving pain, improving gout, etc., and the components work together to play a role in health care and treatment, thereby improving the quality of life of patients.

[0043] Figure 2 The results show that the Chinese herbal foot bath bags prepared in Examples 1-3 have good skin permeability in the presence of volatile oils and disintegrated particles, which are better than those prepared in Comparative Examples 1-3. The skin penetration rate of flavonoid glycosides in the Chinese herbal foot bath bags in Examples 1-3 reaches 80%, and the effective utilization rate is improved, indicating that the components in volatile oils, enzymatic extracts and disintegrated particles interact with each other to promote absorption.

[0044] Figure 3 The results showed that compared with comparative examples 1-3, the Chinese medicine foot bath bag prepared in Examples 1-3 had a higher ΔTEWL, indicating that the skin's barrier function to polar components such as flavonoids, glycosides, alkaloids, and vitamins was reduced, and it had a significant penetration-enhancing effect. The foot bath also replenished moisture, and its effect of opening the skin barrier was non-destructive and reversible.

[0045] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

[0046] The present invention and its implementation methods are described above, which is not restrictive. The drawings are only one of the implementation methods of the present invention, and the actual application is not limited thereto. In short, if ordinary technicians in the field are inspired by it and design methods and embodiments similar to the technical solution without creativity without departing from the purpose of the invention, they should all fall within the protection scope of the present invention.

Claims

1. A health-care Chinese medicine foot bath bag, characterized in that: The traditional Chinese medicine foot bath bag comprises a volatile oil inclusion compound, an enzymatic hydrolysis extract, slow-release disintegrating particles and a non-woven fabric; The enzymatic extract is prepared from the following raw materials: Folium Isatidis, Radix Scutellariae, Rhizoma Coptis, Radix Sophorae Flavescentis, Rhizoma Forsythiae, Rhizoma Polygoni Cuspidati, Rhizoma Chuanxiong, Folium Lophatherum, Cortex Magnoliae, Gypsum, Radix Bupleuri, Rhubarb, Semen Sinapis, Radix Puerariae, complex enzyme, Carbomer 940 and purified water, and the specific preparation method is as follows: A1: Weigh Folium Isatidis, Radix Scutellariae, Rhizoma Coptis, Radix Sophorae Flavescentis, Rhizoma Forsythiae, Radix Tripterygii, Polygonum Cuspidati, Rhizoma Chuanxiong, Folium Lophatherum, Cortex Magnoliae Officinalis, Gypsum, Radix Bupleuri, Rhubarb, Semen Sinapis, and Radix Puerariae, grind and sieve to obtain Chinese medicine powder I; A2: The Chinese medicine powder I obtained in step A1 is heated, soaked, cooled with purified water, and after adjusting the pH, a composite enzyme is added, stirred, and enzymolyzed to obtain an enzymolysis mixture; A3: heating, boiling, and filtering the enzymatic hydrolysis mixture obtained in step A2 to obtain a medicinal residue and an enzymatic hydrolysis extract, adding purified water to the medicinal residue for secondary boiling, combining the two decoctions, and centrifuging to obtain a supernatant; A4: The supernatant obtained in step A3 is filtered through a membrane and ultrafiltered to obtain an enzymatic ultrafiltrate; A5: Weigh Carbomer 940 and dissolve it in the enzymatic ultrafiltrate obtained in step A4 to obtain an enzymatic extract gel, and freeze-dry the enzymatic extract gel to obtain an enzymatic extract.

2. A health-care Chinese medicine foot bath bag according to claim 1, characterized in that: In step A1, the weight ratio of isatis indigotica, scutellaria, rhizoma coptidis, sophora flavescens, forsythia suspensa, trifoliate needle, knotweed, ligusticum chuanxiong, folium lanuginosa, magnolia officinalis, gypsum, radix bupleuri, rhubarb, mustard seeds and kudzu root is 10-15:20-22:20:20-24:15-18:10-15:20-25:25:10-13:18-20:10-12:12-15:10:12:10, and the powder is crushed by a grinder with a sieve of 20 mesh; Step A2: the composite enzyme is composed of cellulase, pectinase and amylase in a mass ratio of 1:2:1, and the mass ratio of the Chinese medicine powder I, purified water and composite enzyme is 1:6:0.

06. The mixture is heated to 80°C in a constant temperature water bath and soaked for 30 min, cooled to 40°C, and the pH is adjusted to 5.0-5.2 with 40% citric acid aqueous solution. The enzymolysis time is 40 min; The decoction time in step A3 is 40 min, the temperature is 80° C., the same amount of purified water as that in the first decoction is added for the second decoction, and the centrifugation process is performed using a high-speed centrifuge at 5000 rpm for 10 min; The membrane filtration in step A4 uses a 0.45 μm water filter membrane, and the ultrafiltration process uses a polypropylene hollow fiber column; In step A5, the mass volume ratio of Carbomer 940 and enzymatic ultrafiltrate is 0.5-2 g: 100 mL, and the dissolution process is carried out in a constant temperature magnetic stirrer with a speed of 80 rpm and a stirring time of 20 min, and is frozen in a -80°C refrigerator for 24 h.

3. A health-care Chinese medicine foot bath bag according to claim 1, characterized in that: The volatile oil inclusion compound is prepared from the following raw materials: perilla leaf, angelica dahurica, safflower, fennel, cinnamon bark, star anise, calamus, fructus aurantii, root of grass grass, camphor fruit, β-cyclodextrin, anhydrous ethanol and purified water. The specific preparation method is as follows: B1: Weigh perilla leaf, angelica dahurica, safflower, fennel, cinnamon bark, star anise, calamus, fructus aurantii, root of grass grass and camphor fruit, crush and sieve to obtain Chinese medicine powder II; B2: extracting the Chinese medicine powder II obtained in step B1 to obtain Chinese medicine volatile oil; B3: dissolving the volatile oil of traditional Chinese medicine obtained in step B2 in anhydrous ethanol to obtain a volatile oil solution, weighing β-cyclodextrin and dissolving it in purified water to obtain a β-cyclodextrin solution; B4: adding the volatile oil solution obtained in step B3 dropwise to the β-cyclodextrin solution for inclusion, and obtaining a crude volatile oil inclusion compound after refrigeration; B5: Filter the crude volatile oil inclusion compound obtained in step B4 to obtain a filter residue, wash and dry it to obtain a volatile oil inclusion compound.

4. A health-care Chinese medicine foot bath bag according to claim 3, characterized in that: In step B1, the mass ratio of perilla leaf, angelica dahurica, safflower, fennel, cinnamon bark, star anise, calamus calamus, fructus aurantii, grass root and camphor fruit is 12-15:10-13:9-12:10:10:8-10:8-10:6:6:6:5-8, and the powder is crushed by a grinder, and the sieve is 40 mesh; The extraction process of step B2 uses supercritical CO2 extraction equipment, the temperature is 40°C, the extraction pressure is 30 MPa, the pressure of separation kettle I is 8 MPa, the pressure of separation kettle II is 6 MPa, and the extraction time is 2 h; In step B3, the mass ratio of the Chinese herbal volatile oil to anhydrous ethanol is 1:1, the mass volume ratio of the β-cyclodextrin to purified water is 1 g:8 mL, and the dissolution process is carried out in a constant temperature magnetic stirrer, stirring for 10 min, the stirring temperature is 40°C, and the rotation speed is 300 rpm; The dripping rate in step B4 is 2-3 drops / s, the inclusion is carried out for 2 hours, and the mixture is refrigerated in a refrigerator at 4°C for 24 hours; In step B5, a Buchner funnel was used for the filtration process. The filter residue was first washed three times with purified water and then washed three times with anhydrous ethanol, 10 mL / times, and dried in an oven at 45°C for 4 h.

5. A health-care Chinese medicine foot bath bag according to claim 1, characterized in that: The sustained-release disintegrating granules are prepared from the following raw materials: ephedra, scutellaria baicalensis, raw liquorice, platycodon, cassia twig, white peony root, rhizoma anemarrhenae, rhizoma rehmanniae, peach kernel, ebony, chicken gizzard lining, hawthorn, almond, betel nut, low-substituted hydroxypropyl cellulose and sodium bicarbonate. The specific preparation method is as follows: C1: Weigh ephedra, scutellaria baicalensis, raw liquorice, platycodon grandiflorum, cinnamon twig, white peony root, rhizoma anemarrhenae, rhizoma rehmanniae, peach kernel, ebony, chicken gizzard lining, hawthorn, apricot kernel and betel nut, grind and sieve to obtain Chinese medicine powder III; C2: Weigh low-substituted hydroxypropyl cellulose and sodium bicarbonate, and mix them with the traditional Chinese medicine powder III obtained in step C1 to obtain an intermediate; C3: Granulate the intermediate obtained in step C2 to obtain sustained-release disintegrating granules.

6. A health-care Chinese medicine foot bath bag according to claim 5, characterized in that: The mass ratio of ephedra, scutellaria baicalensis, raw liquorice, platycodon, cassia twig, white peony root, rhizoma anemarrhenae, rhizoma rehmanniae, peach kernel, black plum, chicken gizzard lining, hawthorn, almond, betel nut, low-substituted hydroxypropyl cellulose and sodium bicarbonate is 13:12-13:11-13:12:12:10-12:10-12:12-15:10:8-11: 10:8-10:6-10:3-5:10:2, the pulverizing process in step C1 uses a high-speed pulverizer, the sieving screen is 20 mesh, the mixing process in step C2 uses a mixer, the mixing time is 10 min, the main shaft speed is 15 r / min, the granulation process in step C3 uses a dry granulator, the feeding speed is 50-60 rpm, the pressure roller speed is 10-12 rpm, the granulation speed is 120-130 rpm, the molding pressure is 160 bar, and the particle size is 2.0-2.5 mm.

7. A method for preparing a health-care Chinese medicine foot bath bag according to any one of claims 1 to 6, characterized in that: The steps include: Step 1: weigh the enzymatic extract and the sustained-release disintegrating granules, mix them, and obtain a primary mixture; Step 2: heating the primary mixture obtained in step 1 under an argon atmosphere, and cooling the primary mixture to obtain a gelled primary mixture; Step 3: weighing the volatile oil inclusion compound and mixing it with the gelled primary mixture obtained in step 2 to obtain a total mixture; Step 4: Encapsulate the total mixture obtained in step 3 to obtain a health-care Chinese medicine foot bath bag.

8. The method for preparing a health-care Chinese medicine foot bath bag according to claim 7, characterized in that: The mass ratio of the enzymatic extract, the volatile oil inclusion compound and the sustained-release disintegrating granules is 8-10:5-9:20-30. The mixing process is carried out in a mixer with a mixing time of 5 min and a spindle speed of 15 r / min. The argon atmosphere flow rate in step 2 is 100-150 mL / min, the heating time is 10 min, and the mixture is cooled to room temperature. Non-woven fabric is used for packaging in step 4.

Images