Full-frequency multi-power cell membrane potential intelligent regulator

Abstract

A full-frequency multi-power cell membrane potential intelligent regulator disclosed by the present invention comprises a space electric field generator, an electric field power regulation circuit and an electric field emission source, the space electric field generator comprises a primary coil and a secondary coil, the primary coil is connected to a power supply module, and one end of the secondary coil is connected with an input end of the electric field power regulation circuit. The other end of the secondary coil is connected with the recharging grounding capacitance circuit, and the output end of the electric field power adjusting circuit is connected with the electric field emission source. Electric fields with different powers can be output through the space electric field generator and the electric field power adjusting circuit, and the electric field emission source is used for forming an electric field in a specific space to adjust the cell membrane potential.

Description

Technical Field

[0001] The invention relates to the technical field of biomedical engineering, in particular to a full-frequency multi-power cell membrane potential intelligent regulator. Background Art

[0002] The cell membrane potential is a key indicator of cell activity. The cell membrane potential includes resting potential and action potential. The resting potential is the potential difference between the two sides of the membrane when the tissue cell is in a quiet state. The action potential is the potential change that occurs on the basis of the resting potential when the cell is stimulated. When the cell is in a quiet state, the positive charge is located on the outside of the membrane and the negative charge is located on the inside of the membrane. This state is called polarization. If the potential difference between the inside and outside of the membrane increases, that is, the value of the resting potential changes in the direction of increasing negative values ​​inside the membrane, it is called hyperpolarization. On the contrary, if the potential difference between the inside and outside of the membrane decreases, that is, the potential inside the membrane changes in the direction of decreasing negative values, it is called depolarization or depolarization.

[0003] There is a significant difference in the electrical potential intensity of human cell membrane potential in a young state and that in an old state. The younger the person, the higher the cell membrane potential, and the older the person, the lower the cell membrane potential. How to regulate the cell membrane potential so that the human cell membrane potential is in a younger state has attracted widespread attention. Summary of the invention

[0004] In order to overcome the above-mentioned shortcomings of the prior art, the purpose of the present invention is to provide a full-frequency multi-power cell membrane potential intelligent regulator, which can achieve the regulation of human cell membrane potential.

[0005] The technical solution adopted by the present invention to solve its technical problems is: a full-frequency multi-power cell membrane potential intelligent regulator, including a space electric field generator, an electric field power regulation circuit and an electric field emission source, a primary coil and a secondary coil of the space electric field generator, the primary coil is connected to a power supply module, one end of the secondary coil is connected to the input end of the electric field power regulation circuit, the other end of the secondary coil is connected to a recharge grounding capacitor circuit, and the output end of the electric field power regulation circuit is connected to the electric field emission source.

[0006] Among them, the output voltage of the space electric field generator is 1000V~3000V.

[0007] As a further improvement of the present invention: the electric field power regulation circuit is provided with a variable resistance module, the variable resistance module is connected to the control module, and the resistance range of the variable resistance module is 0 to 50 MΩ.

[0008] As a further improvement of the present invention: the power module is connected to the space electric field generator, and the working voltage of the power module is 3-220V.

[0009] As a further improvement of the present invention: the recharging grounding capacitor circuit is provided with at least one capacitor, and one end of the recharging grounding capacitor circuit is grounded.

[0010] As a further improvement of the present invention: it also includes a vital sign detector, which is connected to the control module and is used to detect heartbeat data and body temperature data. The control module adjusts the output voltage value of the space electric field generator and the resistance value of the variable resistor module according to the heartbeat data and body temperature data.

[0011] As a further improvement of the present invention: it also includes an electric field frequency regulating circuit, the input end of the electric field frequency regulating circuit is connected to the power supply module, and the output end of the electric field frequency regulating circuit is connected to the input end of the space electric field generator.

[0012] As a further improvement of the present invention: the electric field emission source is an emission pad, and electric field wires are evenly arranged on the emission pad.

[0013] As a further improvement of the present invention: body temperature and / or heartbeat are positively correlated with the resistance value of the variable resistor module.

[0014] As a further improvement of the present invention: the output frequency of the electric field frequency regulating circuit is 5 to 500 Hz.

[0015] Compared with the prior art, the present invention has the following beneficial effects:

[0016] The present invention designs a boost circuit in the space electric field generator to boost the input voltage and output it, and adjusts the output power of the space electric field generator through the electric field power regulation circuit, so that the electric field emission source connected to the output end of the electric field power regulation circuit forms an electric field of the output power, thereby realizing the regulation of the cell membrane potential. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 The figure is a schematic diagram of the principle of a full-frequency multi-power cell membrane potential intelligent regulator according to an embodiment of the present invention.

[0018] Figure 2 The present invention is a schematic structural diagram of a full-frequency multi-power cell membrane potential intelligent regulator according to an embodiment of the present invention.

[0019] Figure 3 The present invention is a logic diagram of a full-frequency multi-power cell membrane potential intelligent regulator according to an embodiment of the present invention.

[0020] Figure 4 The present invention is a logic diagram of a full-frequency multi-power cell membrane potential intelligent regulator according to an embodiment of the present invention.

[0021] Figure 5 It is a schematic diagram of the structure of the transmitting pad according to an embodiment of the present invention.

[0022] Figure 6 This is a schematic diagram of the spatial electric field frequency output for regulating the cell membrane potential of cardiomyocytes according to an embodiment of the present invention.

[0023] Reference numerals:

[0024] 1. Power module, 2. Electric field frequency adjustment circuit, 3. Primary coil, 4. Secondary coil, 5. Electric field power adjustment circuit, 6. Recharge grounding capacitor circuit. DETAILED DESCRIPTION

[0025] In order to make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be clearly and completely described below in conjunction with the specific embodiments of the present invention and the corresponding drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0026] In order to solve the technical problems in the prior art, the present invention is further described in conjunction with the accompanying drawings and embodiments:

[0027] like Figures 1 to 6 As shown, an embodiment of the present invention discloses a full-frequency multi-power cell membrane potential intelligent regulator, including a space electric field generator, an electric field power regulation circuit 5 and an electric field emission source, a primary coil 3 and a secondary coil 4 of the space electric field generator, the primary coil 3 is connected to a power module 1, one end of the secondary coil 4 is connected to the input end of the electric field power regulation circuit 5, the other end of the secondary coil 4 is connected to a recharge grounding capacitor circuit 6, the primary coil 3 is connected to the power module 1, and the output end of the electric field power regulation circuit 5 is connected to the electric field emission source.

[0028] The primary coil 3 and the secondary coil 4 constitute a boost circuit, and the output end of the boost circuit is connected to the input end of the electric field power regulation circuit 5. The boost circuit of the space electric field generator boosts the input voltage and outputs it, which is processed by the electric field power regulation circuit 5 to adjust the electric field power output by the space electric field generator, thereby adjusting the intensity of the output electric field, so that the electric field emission source can stably release static electricity, form an electric field around the electric field emission source, and act on the human body to achieve the regulation of cell membrane potential.

[0029] The primary coil 3 and the secondary coil 4 are increased according to the voltage boosting requirements. For example, if the primary coil is 3220V, the secondary coil 4 increases the coil tenfold and boosts the voltage to 2200V.

[0030] Preferably, the ratio of the primary coil 3 to the secondary coil 4 is 1:2 to 1:10.

[0031] The recharging grounding capacitor circuit 6 is provided with at least one capacitor, one end of which is connected to the secondary coil 4, and the other end of which is connected to the ground. Current is generated in both the primary coil 3 and the secondary coil 4 of the space electric field generator, and the current of the secondary coil 4 of the space electric field generator is grounded through the recharging grounding capacitor circuit 6.

[0032] The output voltage of the space electric field generator is adjustable, and the cell membrane potential needs to be adjusted to a preset potential, corresponding to a set output voltage value and electric field power. To this end, the space electric field generator outputs the set electric field power through the electric field power adjustment circuit 5, and finally the electric field emission source is used to output the electric field corresponding to the set power value and voltage value within a specific spatial range.

[0033] It is important to understand that the activity of charged particles will be different in electric field environments of different power intensities. Charged particles will be more active in higher electric field environments; low potential electric fields will be enhanced in high potential electric field environments. In response to this, in the case of low cell membrane potential, a high potential electric field is applied to the external environment of the human body. The electric field penetrates the human body to stimulate the cell membrane potential, adjust the potential, and increase the cell membrane potential.

[0034] like Figure 4 As shown, the electric field emission source can be an emission pad. The user lies flat on the emission pad, starts the regulator, controls the space electric field generator and the electric field power regulation circuit 5 to work, and outputs a suitable electric field strength through the emission pad to achieve the effect of regulating the cell membrane potential.

[0035] The transmitting pad is provided with electric field wires, which are evenly arranged on the transmitting pad. The resistance of the electric field wires is 0-1Ω per meter. The electric field wires form a loop, which is processed by the space electric field transmitter and the electric field power adjustment circuit 5 to form a large-scale electric field on the transmitting pad. The spatial range of the electric field effect can be expanded by increasing the area of ​​the transmitting pad and the arrangement range of the electric field wires.

[0036] Preferably, the electric field wires are equidistantly distributed on the transmitting pad with a spacing width of 1 to 10 cm, the wire cores at both ends of the electric field wires are butted together to form a loop, and are insulated and sealed with the output end of the electric field power regulation circuit 5 .

[0037] Usually, the space electric field generator and the electric field power regulating circuit 5 are integrated into an integral device, the output end of the device is connected to the loop formed by the electric field wire, and the control module is integrated on the single chip motherboard, and the control module is located in the device.

[0038] More preferably, the interlayer in the middle of the emitting pad is provided with an electric field conductor, and the interlayer is a cloth layer. The interlayer is arranged with 0.1 ohm per meter copper-nickel wires evenly wired, and the wiring width is equal per square meter, and the upper and lower layers of the emitting pad are far-infrared cloth layers.

[0039] like Figures 1 to 3 As shown, the power module 1 is connected to the input end of the space electric field generator, and the power module 1 provides a stable power supply for the entire system. The power module 1 provides an input voltage for the space electric field generator, and the space electric field generator boosts the output voltage, and cooperates with the electric field power regulation circuit 5 to regulate the power of the space electric field generator, thereby regulating the power and intensity of the electric field output by the electric field emission source, and realizing the regulation of different cell membrane potentials.

[0040] Preferably, the input voltage of the space electric field generator ranges from 3V to 220V, and is adjusted to a maximum output of 400V to 3000V by a booster circuit of the space electric field generator.

[0041] Preferably, the input voltage of the space electric field generator is 220V, and the output voltage is 1000V to 3000V. More preferably, the input voltage of the space electric field generator is 220V, and the output voltage is 2000V.

[0042] In this embodiment, the input voltage of the space electric field generator is 220V, and the parameters of the power module 1 can be selected as: 220V / 1A / 50HZ, the working voltage of the power module 1 is AC 220V, the working frequency is 50Hz, and the current is 1A. Therefore, the output voltage of the space electric field generator is AC voltage, and its output end is connected to the electric field power adjustment circuit 5, which outputs electric fields of different intensities to adjust the cell membrane potential.

[0043] Specifically, the boost circuit is provided with two input ports connected to the live wire and the neutral wire of the power module 1. In other words, the live wire and the neutral wire of the power module 1 are connected to the primary coil 3 of the boost circuit, and the 3~220V voltage input by the power module 1 is boosted to 1000V~3000V. The secondary coil 4 of the boost circuit has an output end connected to the variable resistance module of the electric field power regulation circuit 5, and the secondary coil 4 of the boost circuit is provided with another output end connected to the recharge grounding capacitor circuit 6.

[0044] like Figure 2 As shown, the electric field power regulating circuit 5 is provided with a variable resistor module, which is connected to the control module. The resistance value of the variable resistor module can be adjusted to regulate the electric field power output by the space electric field generator. Figure 3 The variable boost circuit shown integrates the boost circuit and the electric field power regulating circuit 5 into one body.

[0045] The output voltage value of the space electric field generator is different from the resistance value of the variable resistor module, which can adjust the membrane potential of different cells. When it is determined that the cell membrane potential needs to be adjusted to the set value, the corresponding output voltage value and resistance value will be determined. After the space electric field generator is connected to the input voltage, the boost circuit is controlled to boost the output voltage value set, and the resistance value set by the variable resistor module is adjusted to adjust the power value of the output electric field. Finally, the electric field of the specific voltage and power is output through the electric field emission source.

[0046] This embodiment also includes a vital sign detector, the electric field power adjustment circuit 5 is connected to the vital sign detector, and the vital sign detector is connected to the control module. The vital sign detector is used to detect the user's vital sign information, and the vital sign information includes the user's body temperature data and heartbeat data. The control module adjusts the output voltage value of the space electric field generator and the resistance value of the variable resistor module according to the user's body temperature data and heartbeat data, so that the electric field generated by the electric field emission source adjusts the cell membrane potential.

[0047] The body temperature and heart rate of the user are fed back by the vital sign detector to determine the required electric field power, intelligently adjust the output voltage of the space electric field generator, and adjust the resistance value of the variable resistor module to adjust the power of the space electric field generator. A specific electric field is formed by the electric field emission source to act on the human body to regulate the cell membrane potential.

[0048] Preferably, the vital sign detector uses a vital sign detection bracelet. The user wears the bracelet, and the heartbeat and body temperature data detected by the bracelet are sent to the control module. The control module intelligently determines the resistance size and adjusts the resistance of the variable resistor module to achieve the voltage value that needs to be matched between 400V and 3000V for the electric field.

[0049] Generally speaking, body temperature and / or heartbeat are positively correlated with the resistance value of the variable resistor module. After receiving the heartbeat and body temperature data sent by the vital sign detector, the control module adjusts the resistance value of the variable resistor module according to the positive correlation.

[0050] The basic adjustment strategy of the space electric field generator and the electric field power adjustment circuit 5 includes: when the heartbeat and temperature are above the normal range, the resistance of the variable resistor module is increased and the power is reduced; when the heartbeat and temperature are within the normal range, the resistance of the variable resistor module is moderate; when the heartbeat and temperature are below the normal range, the resistance of the variable resistor module is decreased and the power is increased.

[0051] The following table shows a specific adjustment strategy for output voltage intensity and variable resistor module resistance value when adjusting cell membrane potential.

[0052]

[0053] This embodiment also includes an electric field frequency adjustment circuit, the input end of the electric field frequency adjustment circuit is connected to the power module 1, and the output end of the electric field frequency adjustment circuit is connected to the input end of the space electric field generator. The electric field frequency adjustment circuit is arranged between the power module 1 and the space electric field generator, adjusts the frequency of the input voltage to the set frequency, and then connects to the input end of the space electric field generator.

[0054] Specifically, the electric field frequency regulating circuit, the space electric field generator / boosting circuit and the electric field power regulating circuit 5 / variable resistor module are integrated as a whole in the space electric field generating device.

[0055] The electric field frequency regulation circuit is provided with two input ports connected to the live wire and the neutral wire of the power module 1, and the two output ports of the electric field frequency regulation circuit are connected to the two input ports of the primary coil 3 of the boost circuit. In other words, the live wire and the neutral wire of the power module 1 are connected to the boost coil of the boost circuit after frequency conversion, and the 3~220V voltage input by the power module 1 is boosted to 1000V~3000V.

[0056] A recharging grounding capacitor circuit 6 is further provided between the single input port of the boost circuit and the ground line. The recharging grounding capacitor circuit 6 includes N capacitors connected in series, where N is a natural number greater than or equal to 1.

[0057] Preferably, the recharge grounding capacitor circuit 6 is provided with a first capacitor and a second capacitor. The first capacitor and the second capacitor are connected in series to form a first capacitor group. One end of the first capacitor group is connected to the other end of the auxiliary coil 4, and the other end of the first capacitor group is grounded.

[0058] More preferably, the recharge grounding capacitor circuit 6 is provided with a first capacitor, a second capacitor, a third capacitor and a third capacitor. The first capacitor and the second capacitor are connected in series to form a first capacitor group, the third capacitor and the third capacitor are connected in series to form a second capacitor group, the first capacitor group and the second capacitor group are connected in parallel, one end of the first capacitor group is connected to the other end of the auxiliary coil 4, and the other end of the first capacitor group is grounded.

[0059] Preferably, the vital sign detector is also connected to the electric field frequency regulating circuit. The vital sign detector is connected to the electric field frequency regulating circuit to provide the user with current electric field frequency data.

[0060] The output frequency of the electric field frequency regulating circuit is 5-500 Hz. The electric field frequency regulating circuit is a prior art circuit, which converts the voltage of the power module 1 into a frequency and then connects it to the primary coil 3 of the space electric field generator.

[0061] According to the research records of cell membrane potential in "Cell Biology", the action potential cycle of the cell membrane at different times is mainly concentrated in the range of 2 to 150ms. According to the frequency conversion of the cell membrane potential action cycle, it will help the cell membrane potential to play an auxiliary synergistic role in different action stages. In this embodiment, the frequency of the input voltage can be adjusted by the electric field frequency adjustment circuit, so that the space electric field generator is connected to the periodically changing input voltage, and the periodically changing output voltage is obtained after the boost process. The resistance value is also adjusted by the variable resistance module of the electric field power adjustment circuit 5, thereby adjusting the electric field power, and the electric field emission source is used to form an electric field with the frequency and resistance value corresponding to the power within a specific spatial range. The frequency of the input voltage / output voltage of the space electric field generator can be specifically set for the action potential cycle of different cell membranes to improve the accuracy and effectiveness of cell membrane potential regulation.

[0062] According to the basic period of cell membrane potential of 2 to 150ms, the corresponding minimum and maximum range values ​​of the electric field fluctuation frequency are set to: 5 to 500 Hz / s. There is a certain limited range for cell membrane potential stimulation, and the duration of each stage is used as a reference as the main frequency for intervening in cell membrane potential.

[0063] For example, taking myocardial cells as an example, the total time of phases 0 to 4 is about 350ms. Among them, the depolarization period of phase 0 is 1 to 2ms, 2ms is taken; the initial repolarization period of phase 1 is 10 to 20ms, 20ms is taken; the plateau period of phase 2 is 100 to 150ms, 150ms is taken; the rapid repolarization period of phase 3 is 100 to 150ms, 150ms is taken; the resting period of phase 4 is 20 to 40ms, 30ms is taken. From this, it can be concluded that the frequency and maintenance time of voltage frequency conversion in each phase of the myocardial cell membrane potential change are:

[0064] Phase 0: 1000ms / 2ms=500Hz / s, maintained for 2ms;

[0065] Phase 1: 1000ms / 20ms=50Hz / s, maintained for 20ms;

[0066] Phase 2: 1000ms / 150ms=6.7Hz / s, take 7Hz, maintain 150ms;

[0067] Phase 3: 1000ms / 150ms=6.7Hz / s, take 7Hz, maintain 150ms;

[0068] Phase 4: 1000ms / 30ms=33.3Hz, take 33Hz / s, maintain 30ms;

[0069] 1000ms / 352ms=2.84 times. If the cell membrane potential of myocardial cells is regulated, then Figure 4 The spatial electric field frequency output is shown.

[0070] Similarly, according to the different action cycles of human cell membrane potential, different cell membrane potential adjustment frequencies are designed to achieve accurate stimulation of different human cell membrane potentials. According to the action cycles of cell membrane potential of different cells, the frequency interference of each complete cycle is carried out in turn to achieve full-frequency stimulation of all cells in the human body.

[0071] This embodiment also includes an operation display module, which provides operation buttons and display functions. The operation display module is integrated on the spatial electric field generating device.

[0072] The present invention is mainly based on biological sign detection and potential adjustment technology. During the working process, the real-time data of human body signs is first obtained through the physical sign detector, and then transmitted to the control module for data processing and analysis. The control module calculates the adjustment amount according to the preset parameters and real-time data, and controls the adjustment module to adjust the potential. During the adjustment process, the physical sign detection module continuously monitors the changes in cell membrane potential, and feeds back the data to the control module in real time to achieve closed-loop feedback adjustment.

[0073] The main functions of the present invention are:

[0074] 1. The present invention designs a space electric field generator and an electric field power regulating circuit to output electric fields of different powers, and uses an electric field emission source to form an electric field in a specific space to regulate the cell membrane potential. According to the electric field power required by different cell membranes, the space electric field generator and the electric field power regulating circuit are used to adjust the electric field to the required power.

[0075] 2. The present invention also monitors the user's heartbeat and body temperature data through a vital sign detector. The control module receives the heartbeat and body temperature data, intelligently matches the electric field power, and controls the spatial electric field generator and the electric field power regulation circuit to output the electric field of the power to regulate the cell membrane potential.

[0076] 3. The present invention also designs an electric field frequency adjustment circuit, which sets the corresponding cell membrane potential adjustment frequency according to different cell membrane potential cycles to achieve precise stimulation of different cell membrane potentials.

[0077] In summary, after reading the present invention document, ordinary technicians in this field can make various other corresponding transformation schemes based on the technical scheme and technical concept of the present invention without creative mental work, which all fall within the scope of protection of the present invention.

Claims

1. A full-frequency multi-power cell membrane potential intelligent regulator, characterized in that: It includes a space electric field generator, an electric field power regulation circuit and an electric field emission source. The space electric field generator includes a primary coil and a secondary coil. The primary coil is connected to a power supply module, one end of the secondary coil is connected to the input end of the electric field power regulation circuit, the other end of the secondary coil is connected to the recharging grounding capacitor circuit, and the output end of the electric field power regulation circuit is connected to the electric field emission source.

2. A full-frequency multi-power cell membrane potential intelligent regulator according to claim 1, characterized in that: The output voltage of the space electric field generator is 1000V~3000V.

3. A full-frequency multi-power cell membrane potential intelligent regulator according to claim 1 or 2, characterized in that: The electric field power regulation circuit is provided with a variable resistance module, the variable resistance module is connected to the control module, and the resistance range of the variable resistance module is 0 to 50 MΩ.

4. A full-frequency multi-power cell membrane potential intelligent regulator according to claim 3, characterized in that: The power supply module is connected to the space electric field generator, and the working voltage of the power supply module is 3-220V.

5. A full-frequency multi-power cell membrane potential intelligent regulator according to claim 4, characterized in that: The recharging grounding capacitor circuit is provided with at least one capacitor, and one end of the recharging grounding capacitor circuit is grounded.

6. A full-frequency multi-power cell membrane potential intelligent regulator according to claim 2, 4 or 5, characterized in that: It also includes a vital sign detector, which is connected to the control module and is used to detect heartbeat data and body temperature data. The control module adjusts the output voltage value of the space electric field generator and the resistance value of the variable resistor module according to the heartbeat data and body temperature data.

7. A full-frequency multi-power cell membrane potential intelligent regulator according to claim 6, characterized in that: It also includes an electric field frequency regulating circuit, the input end of the electric field frequency regulating circuit is connected to the power supply module, and the output end of the electric field frequency regulating circuit is connected to the input end of the space electric field generator.

8. A full-frequency multi-power cell membrane potential intelligent regulator according to claim 1, 2, 5 or 7, characterized in that: The electric field emission source is an emission pad, on which electric field wires are evenly arranged.

9. The full-frequency multi-power cell membrane potential intelligent regulator according to claim 6, characterized in that: Body temperature and / or heartbeat are positively correlated with the resistance value of the variable resistor module.

10. The full-frequency multi-power cell membrane potential intelligent regulator according to claim 7, characterized in that: The output frequency of the electric field frequency adjustment circuit is 5-500 Hz.

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