Method for cutting radioactive application material

Abstract

The invention relates to the technical field of nuclear medicine, in particular to a method for cutting a radioactive application material. The method comprises the following steps: obtaining a focus picture, and identifying the focus picture to obtain a clipping area; cutting the radioactive application material according to the cutting area; in the cutting process, a covering film coating spraying device is arranged behind a cutting device, and a notch is sealed while the radioactive application material is cut. According to the method, the focus position is photographed to recognize the cutting area, then the corresponding cutting size is obtained and used for subsequent cutting of the application material, the application base material or the radiation shielding material, in the application material cutting process, the covering film is sprayed along with the cutting head, radionuclide leakage at a fixed notch is prevented, the sealing effect is achieved, and the service life is prolonged. The preparation efficiency of the radioactive application material can be effectively improved, the use safety is improved, and the radioactive application material has important application value.

Description

Technical Field

[0001] The invention relates to the technical field of nuclear medicine, and in particular to a method for cutting radioactive dressing materials. Background Art

[0002] Nuclear medicine uses radionuclide applicators to treat hemangiomas and keloids, with phosphorus being the most widely used. 32 P] applicator and strontium [ 90 Sr] applicators use the high-energy β rays produced by the decay of radionuclides to act on the surface skin tissue to achieve the purpose of treatment. 32 P] The applicator is a homemade type, usually prepared by hospital staff according to the shape of the lesion. 90 The Sr] applicator is of a fixed shape and needs to cover normal skin tissue during treatment to prevent unnecessary exposure.

[0003] There are many problems in the actual medical operation of the two existing applicators, such as phosphorus [ 32 The preparation method of the applicator is the filter paper method. First, the shape of the scar and other lesion tissues needs to be copied onto transparent plastic paper, and the area and dosage of the medicine need to be calculated using graph paper. Then, the shape of the lesion needs to be printed onto the filter paper and cut out. Then, the calculated P-32 liquid is added to the filter paper and dried. Finally, it is sealed with plastic before use. The preparation process is very cumbersome. The area calculation and cutting in the process are done manually. Deviations and errors will lead to inaccurate medication. In addition, the numerous operation processes and long operation time will also lead to high radiation doses for medical staff.

[0004] For strontium with a fixed shape [ 90 Sr] applicator, because the shape of the lesion is usually irregular, radiation shielding materials are usually needed to cover the normal tissue during treatment, so the shape of the lesion tissue is generally cut out in the radiation shielding material and then attached to the skin tissue to leak out the lesion, so as to achieve auxiliary treatment and shielding effects. It also has the disadvantages of cumbersome operation process and low efficiency. Summary of the invention

[0005] In order to solve the problems existing in the prior art, the present invention provides a method for cutting radioactive dressing materials.

[0006] The present invention has found through research that a key operation of using radionuclide application is to cut radiation shielding materials or application base materials (such as filter paper) or large-area radioactive application materials according to irregular lesion tissues. However, the actual operation is all done manually, with low efficiency and accuracy, which affects the efficiency of medical operations and treatment effects to a certain extent.

[0007] The present invention can effectively improve the cutting efficiency and accuracy by identifying the lesion image to determine the cutting area. At the same time, a covering film coating spraying device is arranged behind the cutting device to seal the incision while cutting the radioactive dressing material to avoid radionuclide leakage and contamination.

[0008] In a first aspect, the present invention provides a method for cutting a radioactive dressing material, comprising: Obtaining a lesion image, and identifying the lesion image to obtain a cropping area; cutting the radioactive dressing material according to the cutting area; During the cutting process, a covering film coating spraying device is arranged behind the cutting device to seal the incision while cutting the radioactive dressing material.

[0009] Furthermore, the raw materials of the covering film coating include one or more of acrylate, polyurethane or UV coating; the cosolvent of the acrylate is ethanol, and the ethanol content is 50%-80%; the solid content of the polyurethane is 30%-50%; and the UV coating is a water-based environmentally friendly coating.

[0010] Furthermore, the nozzle of the covering film coating spraying device is 1-5 mm away from the cutting head, the spraying dimensions include a length of 1-5 mm, a width of 0.5-2 mm, and a thickness of the sprayed film of 10-500 μm.

[0011] Furthermore, after the cutting, heating and / or light treatment is adopted to cure the covering film coating into a film.

[0012] Furthermore, obtaining the lesion image includes: Use a picture taking machine or 3D scanner to take pictures or scan the lesion location to obtain the lesion image; If part of the lesion is located under the skin, the PET-CT technique is used to confirm the area.

[0013] Furthermore, before obtaining the lesion image, the method further includes: If the lesion could not be distinguished from normal tissue by images or instruments, the lesion was stained to distinguish the lesion from the normal skin area.

[0014] Furthermore, if the lesion tissue is in a position that is difficult to photograph (for example, at a curved part of the epidermis), or is deformed after photographing and does not match the actual lesion shape, a transparent material can be used to print the lesion shape and then flatten it for photographing.

[0015] Furthermore, the step of identifying the lesion image to obtain the cropped area includes: The lesion image is adjusted to a black and white mode, wherein the lesion portion is black; and a cropping area is determined according to the black portion and the white portion.

[0016] Further, determining the cropping area according to the black part and the white part includes: Based on the outer contour of the black part, expand outward by 1 to 5 mm as the boundary of the cropping area.

[0017] Furthermore, the cutting includes: cutting using a device with an automated cutting function, such as a laser cutting machine, which can complete the cutting of irregular areas of the target material according to a predetermined cutting size.

[0018] In a second aspect, the present invention provides a dressing material cut by the method described above.

[0019] Furthermore, the dressing material is one or more of a radioactive dressing material (applicator), a radiation shielding material or a base material.

[0020] The method provided by the present invention is applicable to cutting of radioactive dressing materials, wherein the aforementioned radioactive dressing materials are large-area cuttable radionuclide applicators carrying radioactive nuclides; Dressing shielding materials, materials used to cover normal skin tissue, such as strontium [ 90 Sr] radiation shielding material lead rubber used with the applicator; the base material is the base material used to prepare or support the applicator (such as in the preparation of phosphorus [ 32 P] The filter paper used in the process of the applicator is the base material)

[0021] In a third aspect, the present invention provides the use of the radioactive dressing material in preparing biological materials for treating diseases; Preferably, the disease comprises one or more of hemangioma, keloid, melanoma, neurodermatitis or psoriasis.

[0022] The present invention has the following beneficial effects: The present invention acquires and identifies images of lesions, and then processes them to determine the application area and cutting area. A specific cutting method is used to quickly and accurately obtain an applicator, radiation shielding material or base material with a suitable area. The present invention also provides a covering film coating spraying device behind the cutting device, and sealing the incision while cutting the radioactive application material can effectively ensure that the radioactive nuclide does not leak.

[0023] Based on the method provided by the present invention, patients can take pictures of lesions by themselves and transmit them to the hospital to realize remote diagnosis and treatment and determine the shape of the lesions and the dosage of medication in advance, or prepare the required dressing materials in advance, further improving the efficiency of dressing treatment and saving patients' treatment time and medical expenses.

[0024] The method provided by the present invention can significantly improve the efficiency of preparing radionuclide patches, and has high efficiency and accuracy, which is of great significance in the field of patch therapy in nuclear medicine. DETAILED DESCRIPTION

[0025] In order to make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be described clearly and completely below. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0026] The experimental methods involved in the following examples, unless otherwise mentioned, are all conventional methods in the art, for example, reference may be made to experimental manuals in the art, or the conditions recommended in the manufacturer's instructions.

[0027] Unless otherwise specified, the experimental materials and reagents involved in the following examples can be obtained from commercial sources.

[0028] Example

[0029] 1. Lesion photography

[0030] The lesion is photographed using a device with a photographing function, such as a digital camera, mobile phone, SLR camera or video camera, to obtain an electronic picture in the format of jpg, jpeg, raw, tiff, png, BMP, gif or WEBP.

[0031] When shooting, please pay attention to the following: (1) When the color of certain lesions is not very different from that of normal skin tissue, the lesions can be painted brightly, such as black or red with chemical reagents or dyes. At the same time, the photos can be taken under sufficient sunlight.

[0032] (2) The machine with a photographing function used should preferably be one with the function of identifying, measuring or calibrating image size. If it does not have the corresponding function, a scale (such as a ruler) or a standard-sized object (such as a 1mm×1mm square card, etc.) should be photographed at the same time when taking the photo, and the size measurement can be performed after the photo is taken.

[0033] Alternatively, fix the camera parameters, such as distance from the object, exposure, contrast, etc., to obtain a uniform standard ratio between the actual object and the image, which is convenient for unified processing later.

[0034] During formal shooting, the lens should be facing the lesion, and the distance should be within 50cm. The lesion and the ruler should be photographed together. Note that the ruler cannot block the lesion.

[0035] If the lesion tissue is located at the curvature of the epidermis and is difficult to photograph, or if it is deformed after photographing and does not match the actual lesion shape, you can use transparent material to print the lesion shape and then lay it flat for photographing.

[0036] 2. Image processing

[0037] Import the captured image into graphics processing software, such as PS, GIMD, Meitu Xiuxiu or CAD. Eliminate the rest of the image except the lesion shape and the ruler, and adjust the contrast of the image. Preferably, the black and white mode is used, that is, the background is adjusted to white mode, and the lesion shape and the ruler are adjusted to black; or use the cutout function to cut out the lesion shape and the ruler to obtain the cropped area.

[0038] Area calculation: Import the processed image into software with the function of identifying and automatically calculating contour area or relative contour area, such as PS and CAD software, and compare it with the standard size area or with a ruler. The contour area of ​​the lesion obtained in this way will provide support for the amount of medication used in the treatment.

[0039] 3. Cutting

[0040] Choose a machine with laser cutting or physical cutting functions, especially an instrument that can cut according to the shape and outline of the picture. It is preferred to choose a machine that can physically cut and has the function of setting the cutting size.

[0041] For example, a laser cutting machine, a vibration knife cutting machine, a CNC cutting machine, etc. can be used.

[0042] Furthermore, a machine capable of recognizing the outer contour of an image is used, and at the same time, it has the function of enlarging the outer contour in the same proportion. For example, after enlargement, the contour is 1-5mm larger than the original size, ensuring that the edge of the lesion is fully covered.

[0043] The cropping ratio needs to be calibrated before cropping. The processed image data is transferred to the software of the cutting machine, and the shooting ruler in the image is compared with the cropping size of the machine to ensure that the cutting ratio is consistent with the proportion of the photographed object. If the cutting machine does not have the function of setting the cropping size, the image ruler can be cut out, and the cropping ratio can be adjusted after measurement so that the cropped size is consistent with the size of the photographed image. After the cropping ratio is calibrated, the machine can cut according to the irregular shape of the lesion, such as flexible radionuclide applicators, radiation shielding materials, base materials, etc. that can be cut in a large area. In the end, a radioactive applicator (applicator), radiation shielding material or base material with a suitable area and less waste is obtained.

[0044] During the cutting process, a covering film coating spraying device is arranged behind the cutting device to seal the incision while cutting the radioactive dressing material. The covering film coating is made of different materials according to the different cutting objects. The raw materials of the optional covering film coating include one or more of acrylate, polyurethane, and UV coating; wherein the cosolvent of acrylate is ethanol, and the ethanol content is 50%-80%; the solid content of polyurethane is 30%-50%; and the UV coating is a water-based environmentally friendly coating. The film-forming material is atomized and then sprayed. The spraying size is 1-5mm long and 0.5-2mm wide. The thickness of the sprayed film is 10-500μm.

[0045] During cutting, the nozzle works synchronously with the cutting head, and the spraying distance is 1-5mm from the cutting head, so that spraying can be achieved while cutting, which can effectively avoid radionuclide leakage.

[0046] After cutting, heating and / or light treatment may be used to further cure the cover film coating.

[0047] The present invention creatively arranges a covering film coating spraying device behind the cutting device, and during the cutting process, the covering film coating is sprayed while the cutting is in progress, which can seal the radioactive dressing material immediately after cutting to prevent nuclide leakage. In addition, the covering film coating provided by the present invention can be quickly solidified after spraying, and has both better sealing efficiency and better leakage prevention effect, and has important application value in the field of dressing material preparation.

[0048] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A method for cutting radioactive dressing material, characterized in that: include: Obtaining a lesion image, and identifying the lesion image to obtain a cropping area; cutting the radioactive dressing material according to the cutting area; During the cutting process, a covering film coating spraying device is arranged behind the cutting device to seal the incision while cutting the radioactive dressing material.

2. The method according to claim 1, characterized in that: When the radioactive dressing material is of fiber texture, it is cut by laser cutting; When the radioactive dressing material is of high molecular weight, it is cut by a physical cutting method.

3. The method according to claim 1, characterized in that The raw materials of the covering film coating include one or more of acrylate, polyurethane or UV coating; the cosolvent of the acrylate is ethanol, and the ethanol content is 50%-80%; the solid content of the polyurethane is 30%-50%; and the UV coating is a water-based environmentally friendly coating.

4. The method according to any one of claims 1 to 3, characterized in that: The nozzle of the covering film coating spraying device is 1-5 mm away from the cutting head, the spraying size includes a length of 1-5 mm, a width of 0.5-2 mm, and a thickness of the sprayed film of 10-500 μm.

5. The method according to claim 1, characterized in that The obtaining of the lesion image comprises: Use a picture taking machine or 3D scanner to take pictures or scan the lesion location to obtain the lesion image; If part of the lesion is located under the skin, the PET-CT technique is used to confirm the area.

6. The method according to claim 5, characterized in that Before obtaining the lesion image, the method further includes: If the lesion could not be distinguished from normal tissue by images or instruments, the lesion was stained to distinguish the lesion from the normal skin area.

7. The method according to claim 1, characterized in that The step of identifying the lesion image to obtain the cropped area includes: The lesion image is adjusted to a black and white mode, wherein the lesion portion is black; and a cropping area is determined according to the black portion and the white portion.

8. The method according to claim 7, characterized in that Determining the cropping area according to the black part and the white part includes: Based on the outer contour of the black portion, expand outward by 1-5 mm as the boundary of the cropping area.

9. The radioactive dressing material obtained by cutting according to the method of any one of claims 1 to 8.

10. Use of the radioactive dressing material according to claim 7 or 8 in preparing biological materials for treating diseases; Preferably, the disease includes: One or more of hemangioma, keloid, melanoma, neurodermatitis, or psoriasis.