Biochemical sample pretreatment device and method of multi-parameter full-automatic biochemical analysis system

Abstract

The invention discloses a biochemical sample pretreatment device and method of a multi-parameter full-automatic biochemical analysis system, and relates to the technical field of sample pretreatment. Comprising the following steps: 1, sample collection: obtaining a biochemical sample needing to be pretreated and pretreatment requirements, and placing the biochemical sample in a treatment test tube; 2, determining a preprocessing process: presetting a preprocessing method; in the centrifugal treatment process, infrared rays are emitted through the infrared emitter and irradiate a biochemical sample in the treatment tank through the perspective window, then the infrared rays emitted by the infrared emitter are received through the infrared receiver, and whether the biochemical sample is centrifuged or not can be judged by judging the intensity of the received infrared rays; the pretreatment efficiency and the pretreatment accuracy are improved, after the biochemical samples in the treatment mechanism are centrifuged, the treatment mechanism can be taken out from the placement groove through the lifting mechanism, and the situation that centrifugal treatment of the biochemical samples in other treatment mechanisms is hindered is avoided.

Description

Technical Field

[0001] The present invention relates to the technical field of sample pretreatment, and in particular to a biochemical sample pretreatment device and method for a multi-parameter fully automatic biochemical analysis system. Background Art

[0002] Biochemical samples refer to various biological fluids or tissues used for biochemical analysis. These samples are usually used in medical diagnosis, scientific research experiments or disease monitoring. Many samples may contain impurities that interfere with the analysis. Pretreatment of the samples helps remove these interfering substances, thereby improving the sensitivity and specificity of subsequent biochemical analysis.

[0003] Patent publication number CN113758781A discloses a sample pretreatment device and pretreatment method, including a tube body, a filter cup, a sample box and a connecting device; the tube body is open at the top, and an inner cavity is arranged inside; the filter cup is detachably arranged in the inner cavity of the tube body, and a plurality of filter holes are arranged at the bottom of the filter cup; the sample box is detachably arranged at the opening of the tube body; the connecting device is used to control the sample box to communicate with the inner cavity of the tube body. The sample pretreatment device and pretreatment method disclosed in the present application make the pretreatment operation simple and easy to complete, avoid sample contamination and infectious spread, and improve the efficiency and accuracy of sample detection.

[0004] In the process of pre-treating samples, it is important to ensure the timeliness of sample pre-treatment. When there are biochemical samples of acutely poisoned patients in the emergency room, medical staff need to quickly test the blood and urine samples of acutely poisoned patients to confirm the type of poison and formulate a treatment plan as soon as possible. In this urgent situation, the pre-treatment and analysis of biochemical samples must be high-speed, efficient and accurate. At present, when pre-treating samples, the degree of automation is not high, and when biochemical samples are centrifuged, due to the different types of substances contained in the biochemical samples, the centrifugation time required is different. At the same time, biochemical samples of the same substance have different substance concentrations and require different centrifugation times. If the biochemical samples are centrifuged at the same time, the centrifugation efficiency will be low, thereby reducing the efficiency and timeliness of the overall pre-treatment. The above-mentioned device has the disadvantages of not being able to automatically pre-treat the samples and ensure the efficiency and timeliness of the pre-treatment in the scenario where the samples are urgently needed to be pre-treated, and thus the present invention is proposed. Summary of the invention

[0005] The object of the present invention is to provide a biochemical sample pretreatment device and method for a multi-parameter fully automatic biochemical analysis system to solve the problems raised in the above background technology.

[0006] To achieve the above object, the present invention provides the following technical solution: a biochemical sample pretreatment method for a multi-parameter fully automatic biochemical analysis system, the method comprising: Step 1: Sample collection: Obtain the biochemical samples that need to be pretreated and the pretreatment requirements, and place the biochemical samples in the processing tube; Step 2: Determine the pretreatment process: preset the pretreatment method, which includes centrifugation, dilution, reaction and solid-liquid separation. Determine one or more pretreatment methods according to the pretreatment requirements to obtain the pretreatment steps; Step 3: biochemical sample pretreatment: pretreatment of the biochemical sample in the treatment test tube based on the pretreatment step to obtain a pretreated biochemical sample; Several kinds of biochemical samples are obtained, and several kinds of biochemical samples are centrifuged. An infrared transmitter is used to emit radiation to irradiate the biochemical samples, and an infrared receiver is used to receive the radiation emitted by the infrared transmitter. The radiation intensity emitted by the infrared transmitter is received by the infrared receiver when the biochemical samples are centrifuged, and the correlation between the biochemical samples and the radiation intensity is established. When performing the centrifugation operation, the biochemical samples are matched with the biochemical samples to obtain a matching result, and the radiation intensity is determined based on the matching result and the correlation to obtain a standard radiation intensity. The liquid in the test tube is irradiated by the infrared transmitter, and the radiation emitted by the infrared transmitter is received by the infrared receiver to obtain a target radiation intensity. When the target radiation intensity is equal to or greater than the standard radiation intensity, the biochemical sample is centrifuged, and when performing the dilution operation or the reaction operation, the dilution efficiency and the reaction efficiency of the biochemical sample are improved by stirring.

[0007] A biochemical sample pretreatment device for a multi-parameter fully automatic biochemical analysis system comprises a base, a placing table driven by a driving motor is installed on the top outer wall of the base, a plurality of placing slots are provided on the placing table, a processing mechanism for pretreatment of biochemical samples is placed in the placing slots, a lifting mechanism for taking the processing mechanism out of the placing slots is installed on the base, the processing mechanism comprises two processing tanks plugged into the placing slots, the two processing tanks are connected by a solid-liquid separation mechanism, a stirring mechanism for stirring and mixing the articles in the processing tanks is installed on the solid-liquid separation mechanism, a feeding mechanism for feeding materials into the processing tanks is installed on the lifting mechanism, a detachable top cover is installed on the processing tank, a receiving mechanism for cooperating with the feeding mechanism for feeding is installed on the top cover, and the processing tank is provided with a detachable top cover. The unloading mechanism cooperates with the receiving mechanism to complete the unloading mechanism to put materials into the processing tank. The top outer wall of the top cover is installed with a screw slide assembly driven by a rotating rod. The screw in the screw slide assembly is a bidirectional threaded rod. The slides are respectively sleeved on both sides of the bidirectional threaded rod. The two slide parts on the screw slide assembly are installed with ear blocks. The inner walls of the two ear blocks on one of the top covers are respectively embedded with an infrared transmitter and an infrared receiver, and the inner walls of the two ear blocks on the other top cover are respectively embedded with a camera and a fill light. Perspective windows are installed on both sides of the outer wall of the processing tank. The infrared transmitter and the infrared receiver complete infrared emission and reception through the perspective windows, and the centrifugal situation is obtained according to the infrared reception intensity. The camera and the fill light complete the acquisition of the video situation inside the processing tank through the perspective windows.

[0008] Furthermore, the lifting mechanism includes a connecting block installed on the base, a first lifting assembly is installed on the connecting block, a bearing plate is installed at one end of the piston rod of the first lifting assembly, electromagnet blocks are installed on the four corners of the outer wall of the bottom of the bearing plate, and magnetic metal blocks are embedded on the top of the ear blocks. The height adjustment of the processing mechanism is completed by energizing the electromagnet blocks to adsorb the magnetic metal blocks on the ear blocks and then cooperating with the first lifting assembly.

[0009] Furthermore, the unloading mechanism includes a storage tank plugged into both sides of the outer wall of the top of the supporting plate, a connecting pipe is installed at the bottom of the storage tank, a sleeve block is sleeved on the bottom outer wall of the connecting pipe, a second lifting assembly is installed on the bottom outer wall of the supporting plate, one end of a piston rod is fixedly connected to the sleeve block, the inner wall of the sleeve block is fixedly connected to a vertical pipe, the inner wall of the vertical pipe is provided with a unloading trough with a trapezoidal cross-section, vertical grooves are provided at both ends of the inner wall of the vertical pipe, sliders are slidably inserted in the vertical grooves, circular plates are installed between the sliders, and under the action of gravity, the circular plate cooperates with the slider to fall into the bottom of the unloading trough to complete the sealing of the vertical pipe.

[0010] Furthermore, the receiving mechanism includes a connecting sleeve installed on the top cover, the vertical pipe is inserted into the connecting sleeve, a receiving groove is opened on the bottom outer wall of the top cover, mounting plates are installed at both ends of the bottom outer wall of the top cover, a vertical rod is installed between the top inner wall of the receiving groove and the top outer wall of the mounting plate, a groove block is slidably sleeved on the outer wall of the vertical rod, a lifting ring is installed between the groove blocks, a connecting plate is installed between the mounting plates, a fixing block in the shape of an inverted cone is installed on the top outer wall of the connecting plate, the fixing block is inserted in the lifting ring, and a spring surrounding the vertical rod is installed between the bottom outer wall of the groove block and the top outer wall of the mounting plate.

[0011] Furthermore, the solid-liquid separation mechanism comprises a U-shaped separation tube embedded in two top covers of the processing mechanism, a pump is installed on the separation tube, and a filter plate is installed at one of the pipe openings of the separation tube.

[0012] Furthermore, the stirring mechanism includes a gear installed on the top cover and driven by a rotating motor, the outer wall and the inner wall of the separation tube are both provided with annular grooves at the top of the top cover and at the pipe mouth of the separation tube, a first gear ring is installed in the annular groove on the outer wall, an adsorption ring is installed in the annular groove on the inner wall, the first gear ring and the adsorption ring are connected by magnetic attraction, a transmission rod is installed on the inner wall of the adsorption ring through a cross block, a rotatable second gear ring is embedded in the bottom of the inner wall of the processing tank, a number of cleaning rods that are in contact with the inner wall of the processing tank are installed on the top and bottom of the second gear ring, a stirring rod is installed on the inner wall of the cleaning rod located at the bottom of the second gear ring, one of the first gear rings is meshed with the gear, and the other first gear ring is meshed with the second gear ring.

[0013] Furthermore, gravity sensors for monitoring weight changes of the processing tank are installed in the placement grooves, plug blocks are installed on the inner walls of the ear blocks, slots adapted to the plug blocks are opened on the outer walls of the processing tank, and the plug blocks are inserted into the slots, card slots are opened on both sides of the bottom outer wall of the top cover, card blocks adapted to the card slots are installed on the tops of both sides of the inner wall of the processing tank, and the card blocks are inserted into the card slots, and a number of prompt blocks facing the processing mechanism are installed in the middle of the placement table.

[0014] Compared with the prior art, the present invention has the following beneficial effects: The biochemical sample pretreatment device and method of the multi-parameter fully automatic biochemical analysis system, during the centrifugal treatment process, infrared rays are emitted by the infrared transmitter to illuminate the biochemical samples in the treatment tank through the perspective window, and then the infrared rays emitted by the infrared transmitter are received by the infrared receiver. By judging the intensity of the received infrared rays, it can be judged whether the biochemical sample has been centrifuged, which is beneficial to improving the pretreatment efficiency and pretreatment accuracy. When the biochemical samples in the treatment mechanism are centrifuged, the treatment mechanism can be taken out from the placement tank through the lifting mechanism to avoid interfering with the centrifugal treatment of the biochemical samples in other treatment mechanisms.

[0015] At the same time, the supernatant and sediment produced by centrifugation can be separated through the solid-liquid separation mechanism, and the supernatant can be pumped into another processing tank. The material can be put into the two processing tanks through the unloading mechanism and the receiving mechanism. The specific processing tank into which the material is put is determined according to the actual use situation. When it is put into the processing tank storing the supernatant, the dilution or reaction state of the supernatant can be observed through the camera and the fill light, which is convenient for use. The mixing efficiency of the material in the processing tank and the biochemical sample can be checked through the set stirring mechanism, which is convenient for use. Moreover, through the set receiving mechanism, when no unloading is carried out, the lifting ring is closed under the action of the spring, which plays a sealing role to prevent external dust or bacteria from entering the processing tank and affecting the pretreatment results of the biochemical samples, which is convenient for use.

[0016] At the same time, through the provided gravity sensor, the weight of the items in the processing tank can be monitored in real time, and then the materials can be put in according to the weight of the items, which is convenient for use. The ear blocks and the top cover can be fixed on the processing tank through the provided plug blocks and slots. By rotating the rotating rod, the screw in the screw slide assembly is driven to rotate, and the distance between the two ear blocks on the screw slide assembly can be adjusted, and then the top cover and the ear blocks can be removed from the processing tank, which is convenient for maintenance personnel to maintain the components installed on the ear blocks. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a schematic diagram of the overall structure of the present invention; Figure 2 It is a schematic diagram of the internal structure of the placement table of the present invention; Figure 3 It is a schematic diagram of the structure of part of the processing mechanism of the present invention; Figure 4 It is a schematic diagram of the bottom structure of the top cover of the present invention; Figure 5 It is a structural schematic diagram of the lifting mechanism and the unloading mechanism of the present invention; Figure 6 It is a schematic diagram of the cross-sectional structure of the vertical pipe of the present invention; Figure 7 It is a schematic diagram of the cross-sectional structure of the processing tank of the present invention; Figure 8 It is a schematic diagram of the cross-sectional structure of the separation tube of the present invention; Fig. 9 It is a schematic diagram of the enlarged structure of point A of the present invention; Fig.10 It is a schematic diagram of the cross-sectional structure of the top cover of the present invention.

[0018] In the figure: 1, base; 2, placing table; 3, processing mechanism; 301, processing tank; 302, screw slide assembly; 303, top cover; 304, ear block; 305, card block; 306, infrared transmitter; 307, camera; 308, plug block; 309, card slot; 4, lifting mechanism; 401, first lifting assembly; 402, bearing plate; 403, electromagnet block; 404, connecting block; 5, unloading mechanism; 501, storage tank; 502, connecting pipe; 503, second lifting assembly; 504, sleeve block; 505, vertical pipe; 506, vertical slot; 507, slider; 508, round plate; 6 , placement slot; 7, prompt block; 8, gravity sensor; 9, solid-liquid separation mechanism; 901, separation tube; 902, pump; 903, filter plate; 10, stirring mechanism; 1001, gear; 1002, first gear ring; 1003, cleaning rod; 1004, second gear ring; 1005, stirring rod; 1006, transmission rod; 1007, adsorption ring; 1008, horizontal block; 11, receiving mechanism; 1101, connecting sleeve; 1102, lifting ring; 1103, slot block; 1104, vertical rod; 1105, spring; 1106, fixing block; 1107, mounting plate; 12, perspective window. DETAILED DESCRIPTION

[0019] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0020] In the process of dealing with emergency poisoning patients in the emergency room, it is often necessary to obtain biochemical samples of the patients and analyze and study the biochemical samples of the patients to infer how to treat the emergency patients. Before analyzing and studying the biochemical samples, it is often necessary to pre-treat the biochemical samples. The biochemical sample pre-treatment device provided by the present invention is specially used for automating and improving the pre-treatment efficiency of biochemical sample pre-treatment operations. In the process of using the device for biochemical operation pre-treatment, it is necessary to ensure in advance that the power supply of the components in the device is normal, and before each use, the components for storing samples or solvents and other materials need to be cleaned and disinfected to ensure the normal operation of the device. The pre-treatment of biochemical samples can greatly improve data quality, improve analysis efficiency, and ensure the consistency and reliability of experimental operations.

[0021] The present invention provides a technical solution: a biochemical sample pretreatment method of a multi-parameter fully automatic biochemical analysis system, the method comprising: Step 1: Sample collection: Obtain the biochemical samples that need to be pretreated and the pretreatment requirements, and place the biochemical samples in the processing tube; Step 2: Determine the pretreatment process: preset the pretreatment method, which includes centrifugation, dilution, reaction and solid-liquid separation. Determine one or more pretreatment methods according to the pretreatment requirements to obtain the pretreatment steps; Step 3: biochemical sample pretreatment: pretreatment of the biochemical sample in the treatment test tube based on the pretreatment step to obtain a pretreated biochemical sample; It should be noted that in step one, when obtaining the biochemical sample and placing the biochemical sample in the processing test tube, it is necessary to ensure that the biochemical sample is clean and contaminant-free. It should be carried out in a sterile environment to reduce or avoid contamination of the biochemical sample, resulting in poor subsequent pretreatment of the biochemical sample. The pretreatment requirements depend on the type of biochemical sample or are determined by the treating physician, usually centrifugation, dilution and reaction, etc. In step two, the pretreatment method is determined according to the functions of the device. Usually, the device for pretreatment of biochemical samples contains the functions of centrifugation, dilution, reaction and solid-liquid separation. At the same time, it may also have the function of real-time pH monitoring to achieve the function of regulating the pH of the biochemical sample. The pretreatment steps are determined according to the pretreatment requirements. Different treating physicians or biochemical samples have different steps. In step three, the pretreated biochemical sample can be obtained by pretreating the biochemical sample through the pretreatment steps.

[0022] Several kinds of biochemical samples are obtained, and several kinds of biochemical samples are centrifuged. An infrared transmitter is used to emit radiation to irradiate the biochemical samples, and an infrared receiver is used to receive the radiation emitted by the infrared transmitter. The radiation intensity emitted by the infrared transmitter is received by the infrared receiver when the biochemical samples are centrifuged, and the correlation between the biochemical samples and the radiation intensity is established. When performing the centrifugation operation, the biochemical samples are matched with the biochemical samples to obtain a matching result, and the radiation intensity is determined based on the matching result and the correlation to obtain a standard radiation intensity. The liquid in the test tube is irradiated by the infrared transmitter, and the radiation emitted by the infrared transmitter is received by the infrared receiver to obtain a target radiation intensity. When the target radiation intensity is equal to or greater than the standard radiation intensity, the biochemical sample is centrifuged, and when performing the dilution operation or the reaction operation, the dilution efficiency and the reaction efficiency of the biochemical sample are improved by stirring.

[0023] It should be noted that the more types of biochemical samples there are, the richer the biochemical samples that serve as matching sources will be. During the centrifugation process, the better the centrifugation effect, the clearer the supernatant will usually be. The biochemical samples in the test tube are then irradiated with an infrared transmitter, and the intensity of the radiation transmitted through the biochemical samples is received by the infrared receiver. The intensity of the radiation is then compared with the standard intensity of the biochemical samples after centrifugation to determine whether the biochemical samples are qualified. The judgment process is simple and fast, which is conducive to improving the efficiency and accuracy of biochemical sample pretreatment.

[0024] like Figure 1-Figure 10As shown, a biochemical sample pretreatment device of a multi-parameter fully automatic biochemical analysis system includes a base 1, a placement table 2 driven by a driving motor is installed on the top outer wall of the base 1, a plurality of placement slots 6 are opened on the placement table 2, a processing mechanism 3 for pretreatment of biochemical samples is placed in the placement slots 6, a lifting mechanism 4 for taking the processing mechanism 3 out of the placement slots 6 is installed on the base 1, the processing mechanism 3 includes two processing tanks 301 inserted in the placement slots 6, the two processing tanks 301 are connected by a solid-liquid separation mechanism 9, a stirring mechanism 10 for stirring and mixing the items in the processing tanks 301 is installed on the solid-liquid separation mechanism 9, a feeding mechanism 5 for feeding materials into the processing tanks 301 is installed on the lifting mechanism 4, a detachable top cover 303 is installed on the processing tank 301, a receiving mechanism 11 for cooperating with the feeding mechanism 5 to discharge materials is installed on the top cover 303, and the feeding mechanism 5 cooperates with the receiving mechanism 11 to discharge materials. The receiving mechanism 11 completes the feeding of materials into the processing tank 301 by the unloading mechanism 5. The top outer wall of the top cover 303 is equipped with a screw slide assembly 302 driven by a rotating rod. The screw in the screw slide assembly 302 is a bidirectional threaded rod. The slides are respectively sleeved on both sides of the bidirectional threaded rod. The two slide parts on the screw slide assembly 302 are both equipped with ear blocks 304. The inner walls of the two ear blocks 304 on one of the top covers 303 are respectively embedded with an infrared transmitter 306 and an infrared receiver. The inner walls of the two ear blocks 304 on the other top cover 303 are respectively embedded with a camera 307 and a fill light. The outer wall of the processing tank 301 is equipped with perspective windows 12 on both sides. The infrared transmitter 306 and the infrared receiver complete infrared emission and reception through the perspective windows 12, and the centrifugal situation is obtained according to the infrared reception intensity. The camera 307 and the fill light complete the acquisition of the internal video situation of the processing tank 301 through the perspective windows 12.

[0025] It should be noted that when the biochemical sample needs to be pre-processed, the biochemical sample is placed in the processing tank 301 installed with the infrared transmitter 306 in the processing mechanism 3, and the placement table 2 is driven by the driving motor to rotate, so that the biochemical sample in the processing tank 301 can be centrifuged. During the centrifugal process, infrared rays are emitted by the infrared transmitter 306, and the biochemical sample in the processing tank 301 is irradiated through the perspective window 12, and then the infrared rays emitted by the infrared transmitter 306 are received by the infrared receiver. By judging the intensity of the received infrared rays, it can be judged whether the biochemical sample has been centrifuged. Before centrifugation, it is necessary to prepare a variety of biochemical samples as reference samples, and record the infrared intensity of the infrared receiver after the infrared transmitter 306 irradiates the reference sample that has been centrifuged, so as to compare the infrared intensity to judge whether the biochemical sample has been centrifuged successfully. The process of judging whether the centrifugation is completed is simple and fast. It is beneficial to improve the pretreatment efficiency and pretreatment accuracy. At the same time, when the biochemical sample in the processing mechanism 3 is centrifuged, the processing mechanism 3 is taken out from the placement slot 6 through the lifting mechanism 4 to avoid interfering with the centrifugal treatment of the biochemical samples in other processing mechanisms 3. After lifting, the supernatant and the precipitate produced by the centrifugation can be separated through the solid-liquid separation mechanism 9, and the supernatant is pumped to another processing tank 301. The material can be put into the two processing tanks 301 through the unloading mechanism 5 and the receiving mechanism 11. Which material is put into which processing tank 301 is determined according to the actual use. When it is put into the processing tank 301 storing the supernatant, the dilution or reaction state of the supernatant can be observed through the camera 307 and the fill light, which is beneficial to use. The mixing efficiency of the material in the processing tank 301 and the biochemical sample can be adjusted through the provided stirring mechanism 10, which is beneficial to use.

[0026] like Figure 5 As shown, the lifting mechanism 4 includes a connecting block 404 installed on the base 1, a first lifting component 401 is installed on the connecting block 404, a bearing plate 402 is installed at one end of the piston rod of the first lifting component 401, electromagnet blocks 403 are installed at the four corners of the bottom outer wall of the bearing plate 402, and magnetic metal blocks are embedded and installed on the top of the ear blocks 304. The height adjustment of the processing mechanism 3 is completed by energizing the electromagnet block 403 to adsorb the magnetic metal block on the ear block 304 and then cooperating with the first lifting component 401.

[0027] It should be noted that the first lifting component 401 is a component that provides lifting function such as an electric push rod or a hydraulic cylinder. When the lifting mechanism 4 needs to be used, the first lifting component 401 is started to lower the electromagnet block 403 on the carrier plate 402 to fit with the ear block 304 on the processing mechanism 3, and the electromagnet block 403 is energized to adsorb the processing mechanism 3, and then the entire processing mechanism 3 can be taken out from the placement slot 6 to end the centrifugation operation, which is conducive to directly carrying out the next operation and avoiding affecting the centrifugation of other processing mechanisms 3.

[0028] like Figure 5 and Figure 6 As shown, the material discharge mechanism 5 includes a storage tank 501 plugged into both sides of the outer wall of the top of the supporting plate 402, a connecting pipe 502 is installed at the bottom of the storage tank 501, and a sleeve block 504 is sleeved on the bottom outer wall of the connecting pipe 502, and a second lifting component 503 with one end of a piston rod fixedly connected to the sleeve block 504 is installed on the bottom outer wall of the supporting plate 402, and a vertical pipe 505 is fixedly connected to the inner wall of the sleeve block 504. The inner wall of the vertical pipe 505 is provided with a material discharge trough with a trapezoidal cross-section, and vertical grooves 506 are provided at both ends of the inner wall of the vertical pipe 505. Slide blocks 507 are slidably inserted in the vertical grooves 506, and circular plates 508 are installed between the slide blocks 507. Under the action of gravity, the circular plate 508 cooperates with the slide block 507 to fall into the bottom of the material discharge trough to complete the sealing of the vertical pipe 505.

[0029] It should be noted that the second lifting component 503 is a component that provides lifting function such as an electric push rod or a hydraulic cylinder. When the unloading mechanism 5 needs to be used, the material to be put in needs to be stored in the storage tank 501 in advance. Under the action of the gravity of the material, the circular plate 508 will be squeezed to play a sealing role. By setting the vertical groove 506 and the slider 507, the lifting and lowering of the circular plate 508 is more stable.

[0030] like Fig.10 As shown, the receiving mechanism 11 includes a connecting sleeve 1101 installed on the top cover 303, the vertical pipe 505 is inserted into the connecting sleeve 1101, the bottom outer wall of the top cover 303 is provided with a receiving groove, and mounting plates 1107 are installed at both ends of the bottom outer wall of the top cover 303. A vertical rod 1104 is installed between the top inner wall of the receiving groove and the top outer wall of the mounting plate 1107. A groove block 1103 is slidably sleeved on the outer wall of the vertical rod 1104, a lifting ring 1102 is installed between the groove blocks 1103, a connecting plate is installed between the mounting plates 1107, a fixing block 1106 in the shape of an inverted cone is installed on the top outer wall of the connecting plate, the fixing block 1106 is inserted in the lifting ring 1102, and a spring 1105 surrounding the vertical rod 1104 is installed between the bottom outer wall of the groove block 1103 and the top outer wall of the mounting plate 1107.

[0031] It should be noted that when the receiving mechanism 11 is needed, the vertical pipe 505 is inserted into the connecting sleeve 1101 by starting the second lifting component 503, and the second lifting component 503 is continued to start to squeeze the lifting ring 1102. Under the action of the spring 1105, the lifting ring 1102 tends to slowly descend, and the circular plate 508 is lifted by the fixed block 1106, so that the material in the storage tank 501 can be discharged into the processing tank 301. The material discharge chute is shaped like an inverted cone and the fixed block 1106 is shaped like an inverted cone. The lower the lifting ring 1102 is lowered, the faster the material discharge speed is, thereby achieving the effect of controlling the material discharge rate. When the material discharge is completed, the vertical pipe 505 is driven upward by the second lifting component 503, so that the lifting ring 1102 rises under the action of the spring 1105, and the closure is completed, which plays a sealing role, preventing external dust or bacteria from entering the processing tank 301 and affecting the pretreatment results of the biochemical samples, which is convenient for use.

[0032] like Figure 7 and Figure 8 As shown, the solid-liquid separation mechanism 9 includes a U-shaped separation tube 901 embedded in two top covers 303 in the processing mechanism 3, a pump 902 is installed on the separation tube 901, and a filter plate 903 is installed at one of the pipe openings of the separation tube 901.

[0033] It should be noted that by starting the pump 902 on the separation tube 901 and then through the action of the filter plate 903, solid-liquid separation can be performed on one of the processing tanks 301 in the processing mechanism 3, which is convenient for use.

[0034] like Figure 1 As shown, the stirring mechanism 10 includes a gear 1001 installed on the top cover 303 and driven by a rotating motor. The outer wall and the inner wall of the separation tube 901 are both provided with annular grooves at the top of the top cover 303 and at the pipe mouth of the separation tube 901. A first gear ring 1002 is installed in the annular groove of the outer wall, and an adsorption ring 1007 is installed in the annular groove of the inner wall. The first gear ring 1002 is connected to the adsorption ring 1007 by magnetic attraction. The inner wall of the adsorption ring 1007 is provided with a horizontal block 1008. A transmission rod 1006 is installed, and a rotatable second gear ring 1004 is embedded in the bottom of the inner wall of the processing tank 301. Several cleaning rods 1003 that are in contact with the inner wall of the processing tank 301 are installed on the top and bottom of the second gear ring 1004. A stirring rod 1005 is installed on the inner wall of the cleaning rod 1003 located at the bottom of the second gear ring 1004, one of the first gear rings 1002 is meshed with the gear 1001, and the other first gear ring 1002 is meshed with the second gear ring 1004.

[0035] It should be noted that when the stirring mechanism 10 needs to be used, the rotating motor is started to drive the gear 1001 to rotate, and the rotation of the gear 1001 drives the first toothed ring 1002 located at the top of the top cover 303 to rotate, thereby driving the adsorption ring 1007 magnetically connected to it to rotate, thereby driving the transmission rod 1006 and the adsorption ring 1007, the first toothed ring 1002, and the second toothed ring 1004 located at the bottom of the transmission rod 1006 to rotate, and the rotation of the second toothed ring 1004 can drive the cleaning rod 1003 and the stirring rod 1005 to rotate, thereby fully stirring the biochemical samples and materials in the processing tank 301, which is beneficial to improve the mixing efficiency, and then improve the efficiency of dilution, pH adjustment and reaction during the pretreatment process, which is convenient for use.

[0036] like Figure 2 and Figure 4 As shown, gravity sensors 8 for monitoring weight changes of the processing tank 301 are installed in the placement grooves 6, plug blocks 308 are installed on the inner walls of the ear blocks 304, slots adapted to the plug blocks 308 are opened on the outer walls of the processing tank 301, and the plug blocks 308 are inserted into the slots, and card slots 309 are opened on both sides of the bottom outer wall of the top cover 303, and card blocks 305 adapted to the card slots 309 are installed on the tops of both sides of the inner wall of the processing tank 301, and the card blocks 305 are inserted into the card slots 309, and a plurality of prompt blocks 7 facing the processing mechanism 3 are installed in the middle of the placement table 2.

[0037] It should be noted that, by means of the provided gravity sensor 8, the weight of the articles in the processing tank 301 can be monitored in real time, and then the materials can be put in according to the weight of the articles, which is convenient for use; by means of the provided plug block 308 and the slot, the ear block 304 and the top cover 303 can be fixed on the processing tank 301; by rotating the rotating rod, the screw in the screw slide assembly 302 is driven to rotate, and the distance between the two ear blocks 304 on the screw slide assembly 302 can be adjusted, and then the top cover 303 and the ear block 304 can be removed from the processing tank 301; by means of the provided card block 305 and the card slot 309, a positioning function can be played when installing the top cover 303; by means of the provided prompt block 7, a prompt function can be played, and it is convenient for medical staff to distinguish between the processing mechanisms 3 for placing different biochemical samples, which is convenient for use.

[0038] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is limited by the attached embodiments and their equivalents.

Claims

1. A biochemical sample pretreatment method for a multi-parameter fully automatic biochemical analysis system, characterized in that: The method comprises: Step 1: Sample collection: Obtain the biochemical samples that need to be pretreated and the pretreatment requirements, and place the biochemical samples in the processing tube; Step 2: Determine the pretreatment process: preset the pretreatment method, which includes centrifugation, dilution, reaction and solid-liquid separation. Determine one or more pretreatment methods according to the pretreatment requirements to obtain the pretreatment steps; Step 3: biochemical sample pretreatment: pretreatment of the biochemical sample in the treatment test tube based on the pretreatment step to obtain a pretreated biochemical sample; Several kinds of biochemical samples are obtained, and several kinds of biochemical samples are centrifuged. An infrared transmitter is used to emit radiation to irradiate the biochemical samples, and an infrared receiver is used to receive the radiation emitted by the infrared transmitter. The radiation intensity emitted by the infrared transmitter is received by the infrared receiver when the biochemical samples are centrifuged, and the correlation between the biochemical samples and the radiation intensity is established. When performing the centrifugation operation, the biochemical samples are matched with the biochemical samples to obtain a matching result, and the radiation intensity is determined based on the matching result and the correlation to obtain a standard radiation intensity. The liquid in the test tube is irradiated by the infrared transmitter, and the radiation emitted by the infrared transmitter is received by the infrared receiver to obtain a target radiation intensity. When the target radiation intensity is equal to or greater than the standard radiation intensity, the centrifugation of the biochemical sample is completed. When performing the dilution operation or the reaction operation, the dilution efficiency and the reaction efficiency of the biochemical sample are improved by stirring.

2. A biochemical sample pretreatment device for a multi-parameter fully automatic biochemical analysis system, comprising a base (1), characterized in that: A placement table (2) driven by a driving motor is installed on the top outer wall of the base (1); a plurality of placement slots (6) are provided on the placement table (2); a processing mechanism (3) for pre-processing a biochemical sample is placed in the placement slots (6); a lifting mechanism (4) for removing the processing mechanism (3) from the placement slots (6) is installed on the base (1); the processing mechanism (3) comprises two processing tanks (301) plugged into the placement slots (6); the two processing tanks (301) are connected by a solid-liquid separator The solid-liquid separation mechanism (9) is connected to the processing tank (301), the solid-liquid separation mechanism (9) is equipped with a stirring mechanism (10) for stirring and mixing the articles in the processing tank (301), the lifting mechanism (4) is equipped with a feeding mechanism (5) for feeding materials into the processing tank (301), the processing tank (301) is equipped with a detachable top cover (303), and the top cover (303) is equipped with a receiving mechanism (11) for cooperating with the feeding mechanism (5) to discharge materials, and the feeding mechanism (5) cooperates with the receiving mechanism (11) to complete The material discharge mechanism (5) discharges materials into the processing tank (301). The top outer wall of the top cover (303) is equipped with a screw slide assembly (302) driven by a rotating rod. The screw in the screw slide assembly (302) is a bidirectional threaded rod. The slides are respectively sleeved on both sides of the bidirectional threaded rod. The two slide parts on the screw slide assembly (302) are both equipped with ear blocks (304). The inner walls of the two ear blocks (304) on one of the top covers (303) are respectively embedded with an infrared transmitter (306) and an infrared The inner walls of the two ear blocks (304) on the other top cover (303) are respectively embedded with a camera (307) and a fill light. The outer wall of the processing tank (301) is provided with a perspective window (12) on both sides. The infrared transmitter (306) and the infrared receiver transmit and receive infrared rays through the perspective window (12). The centrifugal condition is obtained according to the infrared receiving intensity. The camera (307) and the fill light obtain the video condition inside the processing tank (301) through the perspective window (12).

3. The biochemical sample pretreatment device of the multi-parameter fully automatic biochemical analysis system according to claim 2, characterized in that: The lifting mechanism (4) comprises a connecting block (404) mounted on the base (1), a first lifting assembly (401) being mounted on the connecting block (404), a bearing plate (402) being mounted on one end of a piston rod of the first lifting assembly (401), electromagnet blocks (403) being mounted on four corners of the outer wall at the bottom of the bearing plate (402), and magnetic metal blocks being embedded and mounted on the tops of the ear blocks (304), and the height adjustment of the processing mechanism (3) is completed by energizing the electromagnet blocks (403) to adsorb the magnetic metal blocks on the ear blocks (304) and then cooperating with the first lifting assembly (401).

4. The biochemical sample pretreatment device of the multi-parameter fully automatic biochemical analysis system according to claim 2, characterized in that: The material discharge mechanism (5) comprises a material storage tank (501) plugged into the two sides of the top outer wall of the supporting plate (402); a connecting pipe (502) is installed at the bottom of the material storage tank (501); a sleeve block (504) is sleeved on the bottom outer wall of the connecting pipe (502); a second lifting assembly (503) having one end of a piston rod fixedly connected to the sleeve block (504) is installed on the bottom outer wall of the supporting plate (402); a vertical pipe (505) is fixedly connected to the inner wall of the sleeve block (504); a material discharge trough with a trapezoidal cross section is provided on the inner wall of the vertical pipe (505); vertical grooves (506) are provided at both ends of the inner wall of the vertical pipe (505); a slider (507) is slidably inserted in the vertical groove (506); a circular plate (508) is installed between the sliders (507); under the action of gravity, the circular plate (508) cooperates with the slider (507) to fall into the bottom of the material discharge trough to complete the sealing of the vertical pipe (505).

5. The biochemical sample pretreatment device of the multi-parameter fully automatic biochemical analysis system according to claim 2, characterized in that: The receiving mechanism (11) comprises a connecting sleeve (1101) mounted on the top cover (303), the vertical pipe (505) being inserted into the connecting sleeve (1101), a receiving groove being provided on the bottom outer wall of the top cover (303), mounting plates (1107) being installed at both ends of the bottom outer wall of the top cover (303), a vertical rod (1104) being installed between the top inner wall of the receiving groove and the top outer wall of the mounting plate (1107), and a groove being slidably sleeved on the outer wall of the vertical rod (1104) A lifting ring (1102) is installed between the slot block (1103), a connecting plate is installed between the mounting plates (1107), a fixing block (1106) in the shape of an inverted cone is installed on the top outer wall of the connecting plate, the fixing block (1106) is plugged into the lifting ring (1102), and a spring (1105) surrounding the vertical rod (1104) is installed between the bottom outer wall of the slot block (1103) and the top outer wall of the mounting plate (1107).

6. The biochemical sample pretreatment device of the multi-parameter fully automatic biochemical analysis system according to claim 2, characterized in that: The solid-liquid separation mechanism (9) comprises a U-shaped separation tube (901) embedded in two top covers (303) in the processing mechanism (3), a pump (902) is installed on the separation tube (901), and a filter plate (903) is installed at one of the tube openings of the separation tube (901).

7. The biochemical sample pretreatment device of the multi-parameter fully automatic biochemical analysis system according to claim 2, characterized in that: The stirring mechanism (10) comprises a gear (1001) mounted on a top cover (303) and driven by a rotating motor; an annular groove is provided on the outer wall and inner wall of the separation tube (901) at the top of the top cover (303) and at the tube mouth of the separation tube (901); a first toothed ring (1002) is mounted in the annular groove of the outer wall; an adsorption ring (1007) is mounted in the annular groove of the inner wall; the first toothed ring (1002) and the adsorption ring (1007) are connected by magnetic attraction; a horizontal block (1008) is mounted on the inner wall of the adsorption ring (1007); A transmission rod (1006) is installed, and a rotatable second gear ring (1004) is embedded in the bottom of the inner wall of the processing tank (301). A plurality of cleaning rods (1003) that are in contact with the inner wall of the processing tank (301) are installed on the top and bottom of the second gear ring (1004). A stirring rod (1005) is installed on the inner wall of the cleaning rod (1003) located at the bottom of the second gear ring (1004), wherein one of the first gear rings (1002) is meshed with the gear (1001), and the other first gear ring (1002) is meshed with the second gear ring (1004).

8. The biochemical sample pretreatment device of the multi-parameter fully automatic biochemical analysis system according to claim 2, characterized in that: The placement grooves (6) are each equipped with a gravity sensor (8) for monitoring the weight change of the processing tank (301); an insert block (308) is each equipped on the inner wall of the ear block (304); a slot adapted to the insert block (308) is provided on the outer wall of the processing tank (301); the insert block (308) is plugged into the slot; both sides of the bottom outer wall of the top cover (303) are equipped with a card slot (309); both top sides of the inner wall of the processing tank (301) are equipped with a card block (305) adapted to the card slot (309); the card block (305) is plugged into the card slot (309); and a plurality of prompt blocks (7) facing the processing mechanism (3) are installed in the middle of the placement table (2).

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