Scar tissue blood flow contrast quantitative evaluation device and method

Abstract

The invention discloses a cicatrix tissue blood flow contrast quantitative evaluation device and method, and relates to the field of cicatrix evaluation. The device comprises a diffusion correlation spectrum module, a quantitative evaluation module and an optical probe, and the diffusion correlation spectrum module is used for sending near-infrared light to a detected tissue, detecting scattered light spots of a detected area and calculating a light intensity autocorrelation function according to the scattered light spots; the quantitative evaluation module is used for controlling acquisition of the diffusion correlation spectrum module, storing the acquired data, calculating a blood flow index BFI, calculating a comparison quantitative evaluation parameter Qs for evaluating the scar according to BFI real-time data, and displaying an output result; the optical probe is used for transmitting and diffusing near-infrared light of a related spectrum to the surface of a detected tissue, and receiving scattered light spots after diffuse reflection of the detected tissue to the detection module. According to the quantitative evaluation method, BFI collection of the tested tissue is completed through the device, Qs is calculated, and quantitative evaluation of the scar is achieved. The method overcomes the defects that the influence of subjective factors is large, and the restoration stage cannot be evaluated.

Description

Technical Field

[0001] The present invention relates to the field of scar assessment, and in particular to a scar tissue blood flow comparison and quantitative assessment device and method. Background Art

[0002] The formation mechanism and influencing factors of scars are complex and diverse, and scar assessment is crucial. Currently, scar assessment in clinical practice mainly relies on the scale method. Taking the Vancouver Scar Scale (VSS) as an example, doctors need to subjectively score scars in terms of pigmentation, scar thickness, vascular distribution, flexibility, pain level and itching, which lacks objectivity and accuracy. In addition, the above scar scale assessment method has limitations. The Vancouver Scar Scale cannot be scored immediately after surgical treatment, laser treatment, radiotherapy, etc., and it is necessary to wait until the scar area is repaired before scoring. Therefore, there is an urgent need for a method and device that can instantly and objectively quantify scars. Summary of the invention

[0003] Diffusion correlation spectroscopy (DCS) is an emerging near-infrared spectroscopy non-invasive detection technology for tissue blood flow, which can continuously, real-time and non-invasively obtain blood flow index (BFI) change data. Diffusion correlation spectroscopy uses near-infrared spectrum to illuminate the tissue surface, and calculates the light intensity autocorrelation function of the scattered light spot on the tissue surface to infer the movement state of red blood cells in the tissue, thereby calculating and realizing quantitative detection of blood flow index changes in tissue microcirculation.

[0004] In view of this, the present invention proposes a scar tissue blood flow comparison quantitative evaluation device and method, thereby solving the problem that quantitative evaluation cannot be performed in the existing scar repair stage.

[0005] Essentially, it overcomes the pain points of existing scar scale assessment methods, such as being greatly influenced by doctors' subjective factors and being unable to assess during the repair phase. By detecting the tissue blood flow index, the scar tissue blood flow comparison quantitative assessment parameter (Qs) can be calculated to achieve an objective quantitative assessment of scars.

[0006] The purpose of the present invention is to provide a scar tissue blood flow comparison quantitative evaluation device and method, so as to achieve quantitative evaluation of scars by directly obtaining the blood flow index (BFI).

[0007] To achieve the above object, the technical solution adopted by the present invention is as follows.

[0008] In a first aspect, the present invention provides a scar tissue blood flow contrast and quantitative evaluation device, the scar tissue blood flow contrast and quantitative evaluation device comprising: a diffusion-related spectroscopy module, a quantitative evaluation module and an optical probe; the diffusion-related spectroscopy module and the optical probe are both connected to the quantitative evaluation module; the diffusion-related spectroscopy module is connected to the optical probe;

[0009] The diffusion correlation spectroscopy module is used to send near-infrared light to the measured tissue (including scar tissue, normal tissue around the scar tissue, and contralateral tissue, etc.), detect the scattered light spots in the measured area, calculate the light intensity autocorrelation function based on the scattered light spots to determine the blood flow index (BFI) of the measured area, and can detect the change of the blood flow index of the measured part before and after the laser action in real time;

[0010] The quantitative evaluation module is used to: realize the control of the diffusion correlation spectrum module acquisition, store the acquired data and calculate the blood flow index (BFI), calculate the quantitative evaluation parameter (Qs) for evaluating the blood flow contrast of scar tissue according to the real-time data of the blood flow index (BFI), and display the output result;

[0011] The optical probe is used to transmit near-infrared light of the diffusion-related spectrum to the surface of the measured tissue, and at the same time receive the scattered light spots after diffuse reflection from the measured tissue to the detection module, and control the opening and closing of the light between the optical probe and the measured tissue according to the quantitative evaluation module.

[0012] In a second aspect, the present invention provides a method for quantitatively evaluating blood flow in scar tissue by contrast, the method comprising:

[0013] Step 1: Collection of tissue blood flow data in the scar stabilization stage: placing the optical probe on the surface of the tissue to be tested, and using the diffusion correlation spectroscopy module to carry out real-time collection of blood flow index (BFI) data;

[0014] Step 2: Collection of tissue blood flow data during scar repair: placing the optical probe on the surface of the tissue to be tested, and using the diffusion correlation spectroscopy module to carry out real-time collection of blood flow index (BFI) data;

[0015] Step 3: Data analysis and processing: Calculate the contrast quantitative evaluation parameter (Qs) based on the obtained blood flow index (BFI) data;

[0016] Step 4: Quantitative evaluation result display: Display the real-time changes of the patient's blood flow index (BFI) and compare the quantitative evaluation parameter (Qs) results.

[0017] According to the specific embodiments provided by the present invention, this application discloses the following technical effects:

[0018] The invention discloses a scar tissue blood flow comparison quantitative evaluation device and method, and the scar evaluation field.

[0019] The quantitative evaluation device includes a diffusion-related spectroscopy module, a quantitative evaluation module and an optical probe. The diffusion-related spectroscopy module is used to send near-infrared light to the measured tissue, detect scattered light spots in the measured area, and calculate the light intensity autocorrelation function based on the scattered light spots; the quantitative evaluation module is used to control the acquisition of the diffusion-related spectroscopy module, store the acquired data and calculate the blood flow index (BFI), calculate the quantitative evaluation parameter (Qs) for comparison based on the real-time data of the blood flow index (BFI), and display the output result; the optical probe is used to transmit near-infrared light to the surface of the measured tissue, and at the same time receive the scattered light spots of the measured tissue to the detection module, and control the opening and closing of the light between the optical probe and the measured tissue according to the quantitative evaluation module.

[0020] The quantitative evaluation method completes the collection of the blood flow index (BFI) of the tissue through the device, calculates and compares the quantitative evaluation parameter (Qs), and realizes the quantitative evaluation of the scar. The scar tissue blood flow comparison quantitative evaluation device and method involved in the present invention overcome the shortcomings of the existing scar scale evaluation method being greatly affected by the subjective factors of the doctor and being unable to evaluate in the repair stage, and provides an objective evaluation device and method for scar evaluation. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0022] Figure 1 A schematic diagram of the structure of a scar tissue blood flow comparison and quantitative evaluation device provided by an embodiment of the present invention;

[0023] Figure 2 A flowchart of a method for comparative quantitative evaluation of scar tissue blood flow provided by an embodiment of the present invention. DETAILED DESCRIPTION

[0024] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0025] The present invention provides a scar tissue blood flow comparison and quantitative evaluation device and method, aiming to solve the problem that the existing scar tissue blood flow evaluation method is greatly affected by the subjective factors of doctors and has a long evaluation period.

[0026] Based on this, the present invention provides a scar tissue blood flow comparison and quantitative evaluation device and method. The device includes a diffusion-related spectroscopy module, a quantitative evaluation module and an optical probe, which can directly obtain the changes in the measured blood flow index in real time to perform quantitative evaluation of the scar tissue blood flow; the method completes the collection of the blood flow index (BFI) of the measured tissue through the device, calculates the quantitative evaluation index (Qs), and realizes the quantitative evaluation of the scar.

[0027] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and understandable, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0028] In an exemplary embodiment, Figure 1 As shown, the present invention provides a scar tissue blood flow contrast quantitative evaluation device, including a diffusion-related spectroscopy module 1, a quantitative evaluation module 2 and an optical probe 3; the diffusion-related spectroscopy module 1 and the optical probe 3 are both connected to the quantitative evaluation module 2; the diffusion-related spectroscopy module 1 is connected to the optical probe 3.

[0029] The diffusion correlation spectroscopy module 1 is used to: send near-infrared light to the tissue under test, detect the scattered light spots in the tested area, and calculate the light intensity autocorrelation function based on the scattered light spots;

[0030] The quantitative evaluation module 2 is used to: realize the control of the diffusion correlation spectrum module acquisition, store the acquired data and calculate the blood flow index (BFI), calculate the quantitative evaluation parameter (Qs) for comparison based on the real-time data of the blood flow index (BFI), and display the output result;

[0031] The optical probe 3 is used to transmit near-infrared light of the diffusion-related spectrum to the surface of the measured tissue, and at the same time receive the scattered light spots after diffuse reflection from the measured tissue to the detection module, and control the opening and closing of the light between the optical probe and the measured tissue according to the quantitative evaluation module.

[0032] In this embodiment, the diffusion correlation spectrum module 1 includes: a light source module, a detection module, and an autocorrelation calculation module;

[0033] The light source module is used to: send near-infrared light to the tissue being tested;

[0034] The detection module is used to: receive scattered light spots after diffuse reflection;

[0035] The autocorrelation calculation module is used to calculate the light intensity autocorrelation function according to the near-infrared scattered light spot signal to evaluate the movement state of red blood cells in the measured tissue.

[0036] In this embodiment, the quantitative evaluation module 2 includes: a data storage module, a control module, a blood flow index (BFI) calculation module, a comparative quantitative evaluation parameter (Qs) calculation module, and a display interaction interface;

[0037] The data storage module is used to store the near-infrared scattered light spot signal acquired by the optical probe, the light intensity autocorrelation function signal calculated by the diffusion correlation spectrum module, the real-time change signal of the blood flow index and other related data;

[0038] The control module is used to: control the diffusion-related spectroscopy module and the optical probe to illuminate and detect the tissue under test;

[0039] The blood flow index (BFI) calculation module is used to: obtain a real-time BFI by fitting and calculating according to the light intensity autocorrelation function signal in the data storage module;

[0040] The comparative quantitative evaluation parameter (Qs) calculation module is used to: calculate Qs according to the blood flow index (BFI) signal obtained before and after the laser action;

[0041] The display interaction interface is used to display the real-time changes in BFI and Qs results of the measured area, and the operator can choose to continue or stop the measurement according to the displayed results.

[0042] A specific implementation process of the scar tissue blood flow comparison and quantitative evaluation device in practical application is as follows:

[0043] Step 1: Input the information of the object to be measured.

[0044] The scar tissue blood flow comparison and quantitative evaluation device first inputs the basic information of the subject, including name, age, gender, etc., through an input detection device (such as a touch screen, a keyboard, or an external data interface).

[0045] Step 2: Continuous monitoring of blood flow index (BFI).

[0046] The optical probe 3 is placed on the surface of the measured tissue, and the diffusion correlation spectrum module 1 sends near-infrared light to the area to detect the scattered light spots in the measured area. The blood flow index of the measured area is determined based on the light intensity autocorrelation function of the scattered light spots, and the BFI of the measured part is detected in real time.

[0047] Step 3: Start scar quantitative assessment.

[0048] During the scar repair stage, repeat step 2 to obtain BFI data at multiple locations in real time; start scar quantitative assessment, and analyze and calculate Qs based on the real-time change data of BFI.

[0049] Step 4: Output and display the results.

[0050] The scar tissue blood flow comparison and quantitative evaluation device displays and outputs blood flow index (BFI) data and comparison and quantitative evaluation parameters (Qs) through the display interaction interface.

[0051] In an exemplary embodiment, Figure 2 As shown, a method for quantitatively evaluating blood flow contrast in scar tissue is provided, comprising:

[0052] Step 1: Collection of scar tissue blood flow data.

[0053] Specifically, the optical probe is placed on the surface of the tissue to be tested, and the blood flow index (BFI) data is collected in real time using the diffusion correlation spectroscopy module;

[0054] Specifically, the optical probe is on the surface of the tissue to be measured, including the scar tissue, healthy tissue surrounding the scar tissue, and contralateral tissue;

[0055] Specifically, the blood flow index (BFI) data is multi-position data (ie, scar tissue, normal tissue surrounding the scar tissue, and contralateral tissue).

[0056] Specifically, based on the diffusion correlation spectroscopy technology, the near-infrared scattered light spot signal is detected and the light intensity autocorrelation function is calculated to evaluate the movement state of red blood cells in the measured tissue, and the real-time blood flow index (BFI) signal is obtained by fitting and calculating the light intensity autocorrelation function (g2(τ)).

[0057] Furthermore, the calculation formula of the light intensity autocorrelation function (g2(τ)) is:

[0058]

[0059] Where I(t) represents the light intensity detected at time t, τ is the delay time, and < > represents the time average.

[0060] Furthermore, based on the Siegert relationship, the normalized electric field autocorrelation function can be derived from the measured normalized light intensity autocorrelation function, and the normalized electric field autocorrelation function and the solution of the related diffusion equation can be fitted through a nonlinear minimization algorithm or with the help of a deep learning method to obtain the blood flow index BFI used to characterize tissue blood flow changes.

[0061] Furthermore, in the stable stage, the blood flow index data obtained for scar tissue, normal tissue surrounding the scar tissue, and contralateral tissue are: BFI s1 (t), BFI h1 (t), BFI c1 (t).

[0062] Step 2: scar repair phase, tissue blood flow data collection.

[0063] Specifically, in the scar repair stage, step 1 is repeated to complete the real-time collection of blood flow index (BFI) data;

[0064] Specifically, the diffusion correlation spectroscopy module is used to carry out real-time collection of blood flow index (BFI) data during the scar repair stage;

[0065] Specifically, the blood flow index (BFI) data is also multi-position data (i.e., scar tissue, normal tissue surrounding the scar tissue, and contralateral tissue, etc.);

[0066] Specifically, the process of calculating the blood flow index (BFI) based on diffusion correlation spectroscopy technology is consistent with step 1.

[0067] Furthermore, in the scar repair stage, the blood flow index data obtained for scar tissue, normal tissue surrounding the scar tissue, and contralateral tissue are: BFI s2 (t), BFI h2 (t), BFI c2 (t).

[0068] Step 3: data analysis and processing.

[0069] Specifically, the contrast quantitative assessment parameter (Qs) was calculated based on the obtained blood flow index (BFI) data;

[0070] Specifically, the Qs is calculated based on the obtained multi-position blood flow index data analysis in the resting stage and the repair stage. The calculation process of the Qs involves the selection and processing of multiple parameters, including data of different treatment stages at the same position and data of different positions at the same treatment stage, that is, the changes in the blood flow index in space and time. It can be seen that the quantitative evaluation parameter (Qs) described in the present invention integrates the multi-position blood flow index (BFI) data obtained based on the diffusion correlation spectroscopy technology and is calculated by considering the correlation relationship of the repair stage, and is ultimately used to achieve quantitative evaluation of scars.

[0071] Furthermore, in the scar stabilization stage, the ratios of scar tissue blood flow index to the surrounding healthy tissue and contralateral tissue blood flow index are: rBFI s1 / h1 , rBFI s1 / c1 .Right now,

[0072]

[0073] Furthermore, the scar repair status, the ratio of scar tissue blood flow index to the surrounding healthy tissue and contralateral tissue blood flow index are: rBFI s2 / h2 , rBFI s2 / c2 .Right now,

[0074]

[0075] Furthermore, we compare the quantitative evaluation parameter (Qs), that is,

[0076]

[0077] Step 4: Display the quantitative evaluation results.

[0078] Specifically, the real-time changes of blood flow index (BFI) and the results of comparative quantitative assessment parameters (Qs) are displayed.

[0079] The present invention independently develops a scar tissue blood flow contrast quantitative assessment device based on diffusion correlation spectroscopy technology, and proposes a scar tissue blood flow contrast quantitative assessment method. It is the first time that diffusion correlation spectroscopy technology is used for the quantitative assessment of scars. The contrast quantitative assessment parameter (Qs) is calculated by the change of blood flow index (BFI), and the quantitative assessment of scars is realized. The present invention essentially overcomes the pain points of existing scar scale assessment methods, such as being greatly affected by the subjective factors of doctors and being unable to be assessed during the repair stage, and realizes objective quantitative assessment of scars.

[0080] In addition, there are some alternatives to the above scar tissue blood flow comparison quantitative evaluation device and method that can also achieve the purpose of the present invention, that is, to achieve quantitative evaluation of scars. The following are several possible alternatives:

[0081] (1) Scar quantitative assessment based on multimodal biological signals.

[0082] In addition to the blood flow index, other medical signals of the measured object (such as electrocardiogram, blood pressure, respiratory rate, etc.) also contain rich and effective information. Therefore, a scar quantitative assessment system based on multimodal biological signals can be designed. The system comprehensively judges the scar of the measured object by simultaneously collecting and analyzing multiple medical signals.

[0083] (2) Comprehensive evaluation based on artificial intelligence and big data

[0084] With the continuous development of artificial intelligence and big data technology, we can use these advanced technologies to build a comprehensive evaluation model to achieve accurate prediction of scar tissue blood flow. This model can integrate multi-source data (including biological signals, medical images, blood biochemical indicators, etc.), extract key features through deep learning and data mining algorithms, and train and optimize based on a large amount of historical data to improve the accuracy and reliability of the evaluation.

[0085] It should be noted that although these alternatives can measure scar tissue blood flow, in actual work, the accuracy and consistency of the evaluation results are affected due to factors such as the connection problems between various examination methods, the complexity of data integration, and differences in interpretation capabilities. In addition, it is difficult to achieve the requirements of real-time non-invasive monitoring. Therefore, they are of little use in early warning, medical intervention, and ultimately improving prognosis.

[0086] The technical features of the above embodiments may be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0087] This article uses specific examples to illustrate the principles and implementation methods of this application. The description of the above embodiments is only used to help understand the method and core ideas of this application. At the same time, for those skilled in the art, according to the ideas of this application, there will be changes in the specific implementation methods and application scope. In summary, the content of this specification should not be understood as limiting this application.

Claims

1. A scar tissue blood flow comparison and quantitative evaluation device, characterized in that: The method comprises: a diffusion-related spectroscopy module, a quantitative evaluation module and an optical probe; the diffusion-related spectroscopy module and the optical probe are both connected to the quantitative evaluation module; the diffusion-related spectroscopy module is connected to the optical probe; The diffusion-related spectroscopy module is used to send near-infrared light to the measured tissue, detect the scattered light spots in the measured area, and calculate the light intensity autocorrelation function based on the scattered light spots; the quantitative evaluation module is used to control the acquisition of the diffusion-related spectroscopy module, fit the stored light intensity autocorrelation function to obtain the blood flow index BFI, calculate the comparative quantitative evaluation parameter Qs for scar evaluation based on the real-time data of the blood flow index BF, and display the output result; The optical probe is used to transmit near-infrared light of the diffusion-related spectrum to the surface of the tissue to be measured, and at the same time receive the scattered light spots after diffuse reflection from the tissue to the detection module.

2. The scar tissue blood flow comparison and quantitative evaluation device according to claim 1, characterized in that: The quantitative evaluation module includes: a data storage module, a control module, a blood flow index BFI calculation module, a comparative quantitative evaluation parameter Qs calculation module, and a display interaction interface; The data storage module is used to store the near-infrared scattered light spot signal obtained by the optical probe, i.e., the photon number data, the light intensity autocorrelation function signal calculated by the diffusion-related spectrum module, and the real-time change signal of the blood flow index and other related data; The control module is used to: control the diffusion-related spectroscopy module and the optical probe to illuminate and detect the tissue under test; The blood flow index BFI calculation module is used to: obtain the real-time blood flow index BFI by fitting and calculation according to the light intensity autocorrelation function in the data storage module; The contrast quantitative evaluation parameter Qs calculation module is used to: calculate the contrast quantitative evaluation parameter Qs according to the blood flow index BFI signal; The display interaction interface is used to display the real-time changes of the blood flow index BFI of the measured area and compare the results of the quantitative evaluation parameter Qs.

3. A method for quantitatively evaluating scar tissue blood flow comparison, characterized in that: The scar tissue blood flow comparison and quantitative evaluation method comprises: Step 1: Collection of tissue blood flow data in the scar stabilization stage: placing the optical probe on the surface of the tissue to be tested, and using the diffusion correlation spectroscopy module to carry out real-time collection of blood flow index BFI data; Step 2: Collection of tissue blood flow data during scar repair: placing the optical probe on the surface of the tissue to be tested, and using the diffusion correlation spectroscopy module to carry out real-time collection of blood flow index BFI data; Step 3: Data analysis and processing: Calculate and compare the quantitative evaluation parameter Qs based on the obtained blood flow index BFI data fusion; Step 4: Result display: Display the real-time changes of blood flow index BFI and compare the results of quantitative evaluation parameter Qs.

4. The method for quantitatively evaluating scar tissue blood flow comparison according to claim 3, characterized in that: Placing the optical probe on the surface of the tissue to be tested specifically includes: The measured tissue includes scar tissue, normal tissue surrounding the scar tissue and contralateral tissue; The blood flow index BFI data is multi-position data, namely, scar tissue, healthy tissue surrounding the scar tissue, and contralateral tissue; wherein, the contralateral tissue is tissue in the same position on the other side of the human body; taking the scar tissue in the left forearm as an example, the measured tissue includes the scar tissue in the left forearm, the healthy tissue surrounding the scar tissue in the left forearm, and tissue in the same position in the right forearm.

5. The method for quantitatively evaluating scar tissue blood flow comparison according to claim 3, characterized in that: Tissue blood flow data were collected during the scar stabilization stage and the repair stage, including: The step 1 is to collect blood flow index (BFI) data in real time during the scar stabilization stage; The step 2 is to collect blood flow index (BFI) data in real time during the scar repair stage; The blood flow index BFI data are also multi-location data, namely, scar tissue, normal tissue surrounding the scar tissue, and contralateral tissue.

6. The scar tissue blood flow contrast quantitative evaluation method according to claim 3, characterized in that: The quantitative evaluation parameter Qs is calculated based on the obtained blood flow index BFI data, including: The comparative quantitative evaluation parameter Qs is: The rBFI s1 / h1 , rBFI s1 / c1 In the stable stage of scar, the ratio of scar tissue blood flow index to the blood flow index of surrounding healthy tissue and contralateral tissue is, The rBFI s2 / h2 , rBFI s2 / c2 is the scar repair state, which is the ratio of the scar tissue blood flow index to the surrounding healthy tissue and contralateral tissue blood flow index, that is,

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