Traditional Chinese medicine composition for treating cervical spondylosis and preparation method and application thereof

Abstract

The invention provides a traditional Chinese medicine composition for treating cervical spondylosis. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 4-8 parts of frankincense, 4-8 parts of myrrh, 4-8 parts of radix aconiti, 7-11 parts of angelica sinensis, 11-19 parts of lycopodium clavatum, 8-16 parts of radix angelicae, 4-8 parts of radix aconiti agrestis, 11-19 parts of caulis spatholobi and 7-11 parts of rhizoma arisaematis. The invention further provides application of the traditional Chinese medicine composition. The traditional Chinese medicine has the advantages that clinical and animal experiments prove that the traditional Chinese medicine is better in cervical spondylosis treatment effect, has the effects of dispelling wind and dredging collaterals, promoting blood circulation and dissipating blood stasis, easing joint movement and relieving swelling and pain, and is worthy of popularization.

Description

[Technical field]

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for treating cervical spondylosis, and a preparation method and application thereof. [Background technology]

[0002] With the accelerated development of urbanization, people's learning, working methods and living habits have undergone earth-shaking changes. More and more people have begun to work at desks for a long time and use electronic devices with their heads down, which has greatly increased the incidence of cervical spondylosis. Among them, cervical spondylosis often appears as an early lesion in the course of other types of cervical spondylosis. Long-term head-down activities make the muscles and ligaments of the neck fatigued for a long time, which leads to chronic strain of muscles and ligaments. Over time, the curvature of the cervical spine gradually becomes smaller, straighter, and even arched, and eventually symptoms such as stiffness and pain in the neck, shoulders and back, and limited movement appear. According to the human bowstring mechanical anatomy system, cervical spondylosis is caused by the destruction of the mechanical balance of the cervical bowstring mechanical anatomy system. The system uses the occipital bone, cervical vertebral body, and scapula as bows, and the muscles, ligaments, fascia, joint capsules and other soft tissues attached to them as strings. Under normal physiological conditions, the bow and string of the cervical bowstring mechanical anatomy system maintain a normal mechanical relationship and maintain the physiological curvature of the cervical lordosis. Long-term habit of bending over a desk with head down will increase the stress on the strings, leading to chronic damage to the soft tissues. The damaged strings will compensate through adhesions, scars, and contractures, and the bows will proliferate and develop bone spurs, causing mechanical imbalance in the cervical spine and changes in the physiological curvature of the cervical spine, leading to symptoms such as pain and stiffness in local soft tissues.

[0003] The document "58 cases of knee osteoarthritis treated with Xiaohuoluodan" disclosed "clinical treatment of knee osteoarthritis with Xiaohuoluodan": patients were randomly divided into a Chinese patent medicine group and a glucosamine group. The Chinese patent medicine group took Beijing Tongrentang Xiaohuoluo Pills, 2 pills each time, twice a day; the glucosamine group took Enbet glucosamine soft capsules, 2 capsules each time, twice a day, and both groups took it for 2 consecutive months. The knee arthritis function score, joint rest pain score and ground walking pain score were observed before and after 2 months of treatment. Results: Xiaohuoluodan has a good effect in treating knee osteoarthritis.

[0004] Chinese invention patent CN201010011628.3 discloses "a Chinese herbal medicine for treating cervical and lumbar diseases and its preparation method". The Chinese herbal medicine composition includes: safflower, cinnamon twig, millettia reticulata, turmeric, radix rehmanniae, saposhnikovia divaricata, radix spatholobi, ternate lancea, curcuma, papaya, fructus aurantii, radix aurantii, notopterygium wilfordii, angelica dahurica, gentiana macrophylla, salvia miltiorrhiza, spatholobi, radix spatholobi, radix spatholobi, radix spatholobi, radix spatholobi, radix spatholobi, radix spatholobi, radix spatholobi, radix spatholobi, radix spatholobi, radix spatholobi, radix spatholobi, radix spatholobi, radix spatholobi, The plaster made from the raw materials of earthworm, frankincense, myrrh, rehmannia root, seven-leaf lily, white mustard, cinnamon, Corydalis, black snake, centipede, atractylodes, chuanxiong, earthworm, ephedra, angelica, clematis, stramonium, star maple, dipsacus, angelica dahurica, akebia, turtle shell, Xanthium sibiricum, Sanguisorba officinalis, Panax notoginseng, asarum, borneol, camphor, dried black chicken blood, grub, calomel and yellow lead is effective in treating bone and joint diseases such as cervical spondylosis, lumbar disc herniation, periarthritis of the shoulder, bone hyperplasia, arthritis, etc., with a total effective rate of 95%.

[0005] The Chinese medicine composition of the present invention is modified from Xiaohuoluodan as a base formula, and the internal prescription is changed into an external washing prescription. On the basis of Chuanwu and Caowu, Shenjincao is added to enhance the effect of dispelling wind and unblocking meridians; on the basis of frankincense and myrrh, Millettia spatholobi, Chinese angelica and Angelica dahurica are added, firstly, the light and agile characteristics of vine medicine are brought into play to promote blood circulation, dissipate blood stasis and unblock joints; secondly, Millettia spatholobi and Chinese angelica both have the effect of nourishing blood, can promote blood circulation and nourish blood, have both the function of moving and guarding, and have therapeutic effects on blood deficiency and blood stasis; thirdly, Chinese angelica and Angelica dahurica both have the function of reducing swelling, and have good effect on joint pain and swelling.

[0006] At present, there is no report on the Chinese medicine composition for treating cervical spondylosis of cervical type and its preparation method and application. [Summary of the invention]

[0007] The purpose of the present invention is to provide a Chinese medicine composition for treating cervical spondylosis in view of the deficiencies in the prior art.

[0008] Another object of the present invention is to provide a use of the above-mentioned Chinese medicine composition.

[0009] To achieve the above object, the technical solution adopted by the present invention is:

[0010] In a first aspect, the present invention provides a traditional Chinese medicine composition for treating cervical spondylosis, which is prepared from the following raw materials in parts by weight: 4-8 parts of frankincense, 4-8 parts of myrrh, 4-8 parts of Chuanwu, 7-11 parts of angelica, 11-19 parts of Lycopodiella cuneata, 8-16 parts of Angelica dahurica, 4-8 parts of Aconitum kusnezoffii, 11-19 parts of Millettia reticulata, and 7-11 parts of Arisaema consanguineum.

[0011] Preferably, the traditional Chinese medicine composition is made of the following raw materials in parts by weight: 5-7 parts of frankincense, 5-7 parts of myrrh, 5-7 parts of Chuanwu, 8-10 parts of angelica, 13-17 parts of Lycopodiella cuneata, 10-14 parts of Angelica dahurica, 5-7 parts of Aconitum kusnezoffii, 13-17 parts of Millettia reticulata, and 8-10 parts of Arisaema consanguineum.

[0012] More preferably, the Chinese medicine composition is made of the following raw materials in parts by weight: 6 parts of frankincense, 6 parts of myrrh, 6 parts of Chuanwu, 9 parts of Angelica sinensis, 15 parts of Lycopodiella cuneata, 12 parts of Angelica dahurica, 6 parts of Aconitum kusnezoffii, 15 parts of Millettia spatholobi, and 9 parts of Arisaema consanguineum.

[0013] Preferably, the dosage form of the Chinese medicine composition is an external dosage form.

[0014] Preferably, the preparation method of the medicine is: grind the Chinese medicine composition, use maltose adhesive to mix the powder, maltose and water in a certain proportion, put them into an electric rice cooker to heat them, and after heating, they become a black paste, and apply the heated ointment on the inner wall of a bamboo jar so that it adheres to the affected area without falling off.

[0015] In a second aspect, the present invention provides use of any of the above-described traditional Chinese medicine compositions in the preparation of a drug for treating cervical spondylosis.

[0016] Preferably, the cervical spondylosis is cervical type cervical spondylosis.

[0017] The present invention has the advantages that:

[0018] The Chinese medicine composition of the present invention conforms to the compatibility of "monarch, minister, assistant and messenger". In the prescription, Chuanwu and Caowu are monarchs, which are good at dispelling wind, dampness and pain. Both can penetrate into the tendons and bones, dispel wind, cold and dampness, and relieve pain; Arisaema is a minister, which can dry dampness and resolve phlegm, and assist the monarch to enhance the curative effect; Olibanum and Myrrh are adjuvants, which can promote blood circulation and relieve pain, reduce swelling and promote tissue regeneration, and reduce inflammation and prevent corrosion; Herba Lycopodii, Millettia reticulata, Chinese Angelicae Sinensis and Angelicae Dahuricae are messengers, which can nourish blood and promote blood circulation, dispel wind and dampness. The whole prescription has the effects of dispelling wind and unblocking collaterals, promoting blood circulation and dispersing blood stasis, unblocking joints, and reducing swelling and relieving pain. [Specific implementation method]

[0019] The specific implementation modes provided by the present invention are described in detail below.

[0020] Example 1 Preparation of a Chinese medicine composition for treating cervical spondylosis (I)

[0021] 6 parts of frankincense, 6 parts of myrrh, 6 parts of Chuanwu, 9 parts of angelica, 15 parts of Lycopodiella, 12 parts of Angelica dahurica, 6 parts of Aconiti Kusnezoffii, 15 parts of Millettia reticulata, and 9 parts of Arisaema.

[0022] Example 2 Preparation of a Chinese medicine composition for treating cervical spondylosis (II)

[0023] 6 parts of frankincense, 5 parts of myrrh, 7 parts of Chuanwu, 7 parts of angelica, 19 parts of Lycopodiella, 12 parts of Angelica dahurica, 5 parts of Aconitum, 17 parts of Millettia reticulata, and 7 parts of Arisaema.

[0024] Example 3 Preparation of a Chinese medicine composition for treating cervical spondylosis (III)

[0025] 5 parts of frankincense, 7 parts of myrrh, 4 parts of Chuanwu, 11 parts of angelica, 15 parts of Lycopodiella cuneata, 10 parts of Angelica dahurica, 7 parts of Aconiti Kusnezoffii, 11 parts of Millettia reticulata, and 11 parts of Arisaema consanguineum.

[0026] Example 4 Preparation of a Chinese medicine composition for treating cervical spondylosis (IV)

[0027] 7 parts of frankincense, 4 parts of myrrh, 8 parts of Chuanwu, 9 parts of angelica, 13 parts of Lycopodiella, 14 parts of Angelica dahurica, 4 parts of Aconiti Kusnezoffii, 19 parts of Millettia reticulata, and 9 parts of Arisaema.

[0028] Example 5 Preparation of a Chinese medicine composition for treating cervical spondylosis (V)

[0029] 4 parts of frankincense, 8 parts of myrrh, 6 parts of Chuanwu, 8 parts of angelica, 17 parts of Lycopodiella, 8 parts of Angelica dahurica, 8 parts of Aconiti Kusnezoffii, 15 parts of Millettia reticulata, and 8 parts of Arisaema.

[0030] Example 6 Preparation of a Chinese medicine composition for treating cervical spondylosis (VI)

[0031] 8 parts of frankincense, 6 parts of myrrh, 5 parts of Chuanwu, 10 parts of angelica, 11 parts of Lycopodiella cuneata, 16 parts of Angelica dahurica, 6 parts of Aconiti Kusnezoffii, 13 parts of Millettia reticulata, and 10 parts of Arisaema consanguineum.

[0032] Example 7 Preparation of a Chinese medicine composition for treating cervical spondylosis (VII)

[0033] 6 parts of frankincense, 7 parts of myrrh, 4 parts of Chuanwu, 11 parts of angelica, 15 parts of Lycopodiella cuneata, 10 parts of Angelica dahurica, 7 parts of Aconiti Kusnezoffii, 11 parts of Millettia reticulata, and 11 parts of Arisaema consanguineum.

[0034] Example 8 Preparation of a Chinese medicine composition for treating cervical spondylosis (VIII)

[0035] 5 parts of frankincense, 4 parts of myrrh, 8 parts of Chuanwu, 9 parts of angelica, 13 parts of Lycopodiella, 14 parts of Angelica dahurica, 4 parts of Aconiti Kusnezoffii, 19 parts of Millettia reticulata, and 9 parts of Arisaema.

[0036] Example 9 Preparation of a Chinese medicine composition for treating cervical spondylosis (IX)

[0037] 7 parts of frankincense, 8 parts of myrrh, 6 parts of Chuanwu, 8 parts of angelica, 17 parts of Lycopodiella, 8 parts of Angelica dahurica, 8 parts of Aconiti Kusnezoffii, 15 parts of Millettia reticulata, and 8 parts of Arisaema.

[0038] Example 10 Preparation of a Chinese medicine composition for treating cervical spondylosis (X)

[0039] 4 parts of frankincense, 6 parts of myrrh, 5 parts of Chuanwu, 10 parts of angelica, 11 parts of Lycopodiella cuneata, 16 parts of Angelica dahurica, 6 parts of Aconiti Kusnezoffii, 13 parts of Millettia reticulata, and 10 parts of Arisaema consanguineum.

[0040] Example 11 Preparation of a Chinese medicine composition for treating cervical spondylosis (XI)

[0041] 8 parts of frankincense, 5 parts of myrrh, 7 parts of Chuanwu, 7 parts of angelica, 19 parts of Lycopodiella, 12 parts of Angelica dahurica, 5 parts of Aconitum, 17 parts of Millettia reticulata, and 7 parts of Arisaema.

[0042] Example 12 Clinical Trial

[0043] Fei Moumou, female, 89 years old, had a cervical spine score of 7 before admission, and the treatment time was from 2023.6.10 to 2023.6.24. The treatment drug was the Chinese medicine composition of the present invention, and the cupping area was the shoulder and neck. After the treatment, the cervical spine score was 12.

[0044] Mr. Shao, male, 56 years old, had a cervical spine score of 8 points before admission, and the treatment time was 2023.11.5-2023.11.9. The treatment drug was the Chinese medicine composition of the present invention, and the cupping area was the shoulder and neck. After the treatment, the cervical spine score was 13 points.

[0045] Lin, male, 65 years old, had a cervical vertebra score of 6 before admission, and the treatment time was from 2023.7.30 to 2023.8.4. The treatment drug was the Chinese medicine composition of the present invention, and the cupping area was the shoulder and neck. After the treatment, the cervical vertebra score was 11.

[0046] Zuo Moumou, female, 89 years old, had a cervical spine score of 6 before admission, and the treatment time was from September 10, 2023 to September 24, 2023. The treatment drug was the Chinese medicine composition of the present invention, and the cupping area was the shoulder and neck. After the treatment, the cervical spine score was 12.

[0047] Huang Moumou, male, 90 years old, had a cervical vertebra score of 6 before admission, and the treatment time was 2023.5.16-2023.5.30. The treatment drug was the Chinese medicine composition of the present invention, and the cupping area was the shoulder and neck. After the treatment, the cervical vertebra score was 12 points.

[0048] Zhang XX, male, 60 years old, had a cervical vertebra score of 6 before admission, and the treatment time was from 2023.7.20 to 2023.8.4. The treatment drug was the Chinese medicine composition of the present invention, and the cupping area was the shoulder and neck. After the treatment, the cervical vertebra score was 12.

[0049] Example 13 Animal Experiment

[0050] 1. Experimental Materials

[0051] 1.1 Animal grouping

[0052] 50 SD male rats, weighing about (250±10) g, were purchased from Shanghai Xipuer-Bikai Experimental Animal Co., Ltd. They were fed normally for 1 week, and after adapting to the environment and showing no abnormalities, they were weighed and divided into five groups according to the random number method: the present invention group, control group 1, control group 2, model group, and blank group, with 10 rats in each group.

[0053] 1.2 Modeling

[0054] The rat knee osteoarthritis model was established using the modified Hulth modeling method: 1 day before surgery, the left lower limbs of rats in each group were depilated with 8% sodium sulfide aqueous solution. No food was given for 12 hours and no water was given for 4 hours before surgery. The surgery was performed on a clean bench in the animal laboratory. After intraperitoneal anesthesia with 10% chloral hydrate 0.2ml / 100g, the rats were fixed on a mouse board in the supine position. The left knee of each rat was routinely disinfected with iodine solution for 3 times, and sterile towels were laid. The medial side of the left knee joint of the rat was taken as the surgical approach, and a longitudinal incision was made from the side of the patellar tendon, with a range of about 1 cm, and the medial collateral ligament was cut off, so that the knee joint was in an extremely flexed state, the patella was everted, the joint cavity was exposed, the anterior cruciate ligament was cut off, the medial meniscus was removed, and the drawer test was performed. After a positive result, it was alternately rinsed with complex iodine and normal saline for 2 times to clean the bloody liquid in the wound, and then 80,000 U of gentamicin sulfate injection was dripped and infiltrated into the surgical field to prevent intra-articular infection, and then the incision was sutured layer by layer with 3-0 mousse thread, and sterile dressing was used to bandage, and the operation was completed. The normal group was given a sham operation, only the joint cavity was opened, the ligament and meniscus were not damaged, the skin was sutured, and sterile dressing was used. During the operation, the joint cartilage surface of each group should be protected from damage. The injured limb was not fixed after the operation, and it was allowed to move freely. Each operated rat was injected with 80,000 U of penicillin per time in the buttocks, once a day for 3 consecutive days, and the wound of the rat was disinfected with complex iodine once a day to prevent wound infection. The animals were observed to be lame on the second day after surgery, and the diet and water were normal, and there was no infection in the wound. One week after the operation, all modeling rats survived, the surgical wounds had no redness, swelling, or suppuration, the wounds were basically healed, the reactions were sensitive, and the excretion was normal. The rats were forced to move once a day, 30 minutes each time, for 4 consecutive weeks.

[0055] 1.3 Drugs

[0056] The invention comprises 6 parts of frankincense, 6 parts of myrrh, 6 parts of Chuanwu, 9 parts of angelica, 15 parts of Lycopodiella cuneata, 12 parts of Angelica dahurica, 6 parts of Aconiti Kusnezoffii, 15 parts of Millettia spatholobi, and 9 parts of Arisaema consanguineum (the drugs are crushed, and after passing through a maltose adhesive, they are placed in an electric rice cooker and heated to form a black paste, and the heated ointment is smeared on gauze for later use);

[0057] Control group 1: Xiaohuo Luo Wan (using compound Xiaohuo Luo Wan produced by Beijing Tong Ren Tang, oral administration);

[0058] Control group 2: 6 parts of Chuanxiong, 6 parts of Myrrh, 6 parts of Chuanwu, 9 parts of Angelica, 12 parts of Liquidambar formosana, 10 parts of Ephedra, 6 parts of Aconiti Kusnezoffii, 15 parts of Millettia reticulata, 6 parts of Inula japonica (preparation method is the same as the Chinese medicine composition of the present invention);

[0059] Model group: normal saline;

[0060] Blank group: normal saline.

[0061] From the first day of the experiment, the control group 1 was treated with Xiaohuo Luo Dan by gavage (7.8 ml / kg / day), the control group 2 and the present invention group were treated with control group 2 and the present invention by external application, once a day, and the model group and the blank group were treated with an equal volume of normal saline by gavage, which lasted for 4 weeks.

[0062] 1.4 Collection indicators

[0063] After 4 weeks, 1 day before surgery, the abdomen of each group of rats was depilated with 8% sodium sulfide aqueous solution. After the last administration, the rats were fasted for 12 hours. After being anesthetized, they were placed on the mouse board of the clean bench in the animal laboratory, placed in a supine position, the abdominal wall was disinfected, and a sterile towel was laid. A V-shaped incision was made, the abdominal wall was cut from bottom to top, the abdominal wall was opened and fixed, the abdominal cavity was entered, the internal organs were removed, the abdominal aorta was exposed, 5 ml of arterial blood was taken, injected into the blood collection tube, placed in a 50°C constant temperature box for 2 hours, and then centrifuged (3000r / min, 15min), and 1 ml of the supernatant was taken and placed in a -20°C refrigerator for testing.

[0064] 1.5 Detection

[0065] Detection of experimental indicators IL-1β and TNF-ɑ.

[0066] 1.6 Statistical analysis

[0067] All data results of this experiment were analyzed using SPSS18.0 statistical software and expressed as mean ± standard deviation. One-way analysis of variance was used to test the significance of differences between groups. P<0.05 indicated statistical significance.

[0068] 2. Experimental results

[0069] 2.1 General

[0070] During the experiment, there was no death in each group of rats, they ate and drank water normally, their weight increased, their reactions were sensitive, their fur was bright and clean, and their excretion was normal. Compared with the rats in the control group and the rats in the model group, the rats in the present invention had more activities.

[0071] 2.2 IL-1β detection

[0072] Compared with the model group and the control group: the IL-1β content level in the serum of the rats in the model group was significantly higher (P<0.01), and the difference was statistically significant; compared with the present invention group and the model group: the IL-1β content level in the serum of the rats in the present invention group was significantly lower (P<0.01), and the difference was statistically significant; compared with the present invention group and the control group 1 and the control group 2: the IL-1β content level in the serum of the rats in the present invention group was significantly lower (P<0.01), and the difference was statistically significant; compared with the control group and the model group: the IL-1β content level in the serum of the rats in the control group was significantly lower (P<0.01), and the difference was statistically significant, as shown in Table 1.

[0073] Table 1

[0074]

[0075] Note: #Compared with the normal group, P<0.01; *Compared with the model group, P<0.01; &Compared with the control group, P<0.01.

[0076] 2.2 TNF-ɑ detection

[0077] Compared with the model group and the blank group: the TNF-ɑ content in the serum of the rats in the model group was significantly higher (P<0.01), and the difference was statistically significant; compared with the present invention group and the model group: the TNF-ɑ content in the serum of the rats in the experimental group was significantly lower (P<0.01), and the difference was statistically significant; compared with the present invention group and the control group: the TNF-ɑ content in the serum of the rats in the present invention group was significantly lower (P<0.01), and the difference was statistically significant; compared with the control group 1 and the control group 2 and the model group: the TNF-ɑ content in the serum of the rats in the control group was lower (P<0.05), and the difference was statistically significant, as shown in Table 2.

[0078] Table 2

[0079]

[0080] Note: #Compared with the normal group, P<0.01; *Compared with the model group, P<0.01; &Compared with the control group, P<0.05.

[0081] The above-mentioned related explanations and descriptions of the embodiments are for the convenience of those skilled in the art to understand and apply the present invention. It is obvious that those familiar with the art can easily make various modifications to these contents and apply the general principles described herein to other embodiments without creative work. Therefore, the present invention is not limited to the above-mentioned related explanations and descriptions of the embodiments. Improvements and modifications made by those skilled in the art based on the disclosure of the present invention without departing from the scope of the present invention should be within the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating cervical spondylosis, characterized in that: The invention is prepared from the following raw materials in parts by weight: 4-8 parts of frankincense, 4-8 parts of myrrh, 4-8 parts of Chuanwu, 7-11 parts of angelica, 11-19 parts of Lycopodiella cuneata, 8-16 parts of Angelica dahurica, 4-8 parts of Aconitum kusnezoffii, 11-19 parts of Millettia reticulata and 7-11 parts of Arisaema consanguineum.

2. The Chinese medicine composition according to claim 1, characterized in that: The invention is prepared from the following raw materials in parts by weight: 5-7 parts of frankincense, 5-7 parts of myrrh, 5-7 parts of Chuanwu, 8-10 parts of angelica, 13-17 parts of Lycopodiella cuneata, 10-14 parts of Angelica dahurica, 5-7 parts of Aconitum kusnezoffii, 13-17 parts of Millettia reticulata and 8-10 parts of Arisaema consanguineum.

3. The Chinese medicine composition according to claim 2, characterized in that: The invention is prepared from the following raw materials in parts by weight: 6 parts of frankincense, 6 parts of myrrh, 6 parts of Chuanwu, 9 parts of angelica, 15 parts of Lycopodiella cuneata, 12 parts of Angelica dahurica, 6 parts of Aconitum kusnezoffii, 15 parts of Millettia spatholobi and 9 parts of Arisaema consanguineum.

4. The Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The dosage form of the Chinese medicine composition is an external dosage form.

5. The Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The preparation method of the traditional Chinese medicine composition is as follows: the traditional Chinese medicine composition is crushed, the powder, maltose and water are mixed in a certain proportion by a maltose adhesive, and the mixture is put into an electric rice cooker for heating to form a black paste, and the heated ointment is applied to the inner wall of a bamboo pot so that the ointment adheres to the affected area without falling off, so as to treat the affected area.

6. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of medicines for treating cervical spondylosis.

7. The use according to claim 6, characterized in that: The cervical spondylosis is cervical type cervical spondylosis.

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