A clinical medicinal solid reagent dissolution device

Abstract

The present invention provides a clinical medicinal solid reagent dissolving device, belonging to the technical field of dissolving medicinal solid reagents. It includes a fixed seat, and the outside of the fixed seat is fixedly connected with a first fixing frame and a second fixing frame. A grinding powder chamber is assembled in the second fixing frame. The top of the first fixing frame is symmetrically installed with second electric telescopic rods, and the bottom of the first fixing frame is symmetrically installed with first electric telescopic rods. By setting a current limiting component, the solid reagent after being pulverized in the grinding powder chamber is not added to the dissolving tank for dissolution at one time, but is gradually added into the dissolving tank, so that the reagent entering the dissolving tank can fully contact and dissolve with the solution in the dissolving tank. Compared with the method of adding to the dissolving tank for dissolution at one time, the dissolution efficiency is higher, and the working efficiency of the device is further improved.

Description

Technical Field

[0001] The invention relates to the technical field of dissolving medicinal solid reagents, and in particular to a clinical medicinal solid reagent dissolving device. Background Art

[0002] When conducting clinical pharmaceutical experiments, solid reagents need to be dissolved. In the specific operation, the solid reagents and solutions are mostly poured into a container, and then the operator holds the container and shakes it or uses a glass rod to stir and dissolve it, finally achieving the dissolution of the solid reagent. The solid reagent dissolving device for clinical pharmacy is a device specially designed for the field of clinical pharmacy. It is used to dissolve solid reagents efficiently and accurately to meet the needs of drug development, formulation preparation, clinical trials and other processes.

[0003] Existing dissolution devices generally achieve automatic dissolution of solid reagents by setting up a grinding mechanism and a stirring mechanism, that is, the solid reagent to be dissolved is ground and crushed by a grinding mechanism, and the crushed solid reagent is then mixed with a solution, and stirred and mixed by a stirring mechanism, so as to improve the dissolution efficiency of the solid reagent. However, since the ground solid reagent is added to the solution at one time, it is easy to cause the particles of the reagent to adhere to each other, thereby reducing the effective surface area in contact with the solvent, and ultimately affecting the dissolution rate. Secondly, in the process of crushing the solid reagent by the grinding mechanism, it is inevitable that powder and particle reagent residues will appear on the outside, which will then cause the dissolved amount of the reagent to be lower than the weighing value, affecting the final experimental data. Therefore, the present application provides a clinical pharmaceutical solid reagent dissolution device to meet the needs. Summary of the invention

[0004] The technical problem to be solved by the present invention is to provide a clinical pharmaceutical solid reagent dissolving device to solve the problem that the existing dissolving device has low dissolving efficiency and is prone to produce crushed solid reagent residues in the device.

[0005] In order to solve the above technical problems, the present invention provides the following technical solutions:

[0006] A clinical medicinal solid reagent dissolving device, comprising a fixed seat, wherein a first fixing frame and a second fixing frame are fixedly connected to the outside of the fixed seat, a grinding chamber is assembled in the second fixing frame, second electric telescopic rods are symmetrically installed at the top end of the first fixing frame, first electric telescopic rods are symmetrically installed at the bottom end of the first fixing frame, an installation frame is fixedly connected to the end of the second electric telescopic rod, a tray is fixedly connected to the end of the first electric telescopic rod, a dissolving tank is placed on the tray, a first connecting rod is sleeved in the grinding chamber, a sealing cover is fixedly connected to the bottom of the installation frame, and a servo motor is arranged on the top of the sealing cover; a connection assembly for associating the servo motor with the first connecting rod, and the connection assembly is respectively connected between the drive shaft of the servo motor and the first connecting rod; a current limiting assembly for restricting the discharge speed of the crushed solid reagent in the grinding chamber, and the current limiting assembly is respectively connected between the grinding chamber and the first connecting rod; a vibration assembly for generating vibration in the grinding chamber to discharge the residual reagent, and the vibration assembly is connected to the inner side wall of the grinding chamber.

[0007] Optionally, guide rods corresponding to the moving ranges of the installation frame and the tray are arranged on the fixed seat, the installation frame and the tray are both movably sleeved outside the guide rods, a controller is fixedly connected to the outside of the fixed seat, and the controller is electrically connected to the first electric telescopic rod, the second electric telescopic rod and the servo motor.

[0008] Optionally, one end of the first connecting rod is located inside the grinding chamber, and the other end of the first connecting rod extends outside the grinding chamber and is fixedly connected with uniformly distributed stirring rods. A crushing column and a crushing disc are fixedly connected to the outside of the area where the first connecting rod is located in the grinding chamber.

[0009] Optionally, a storage groove adapted to the bottom shape of the dissolving tank is formed on the tray, and a first annular guard plate surrounding the outside of the storage groove is fixedly connected to the tray. Uniformly distributed reinforcing ribs are arranged between the outer side wall of the first annular guard plate and the tray.

[0010] Optionally, the connection assembly includes a second connecting rod fixedly connected to the outside of the drive shaft of the servo motor and a transmission sleeve fixedly connected to the end of the first connecting rod. A transmission head is fixedly connected to the end of the second connecting rod, and a docking groove adapted to the shape of the transmission head is formed in the transmission sleeve.

[0011] Optionally, the transmission sleeve is located at one end of the first connecting rod away from the stirring rod, the second connecting rod is movably connected to the sealing cover through a bearing, and an inclined surface is arranged at the entrance of the docking groove.

[0012] Optionally, the current-limiting component includes a current-limiting sleeve fixedly connected to the outside of the first connecting rod and a second through-opening formed at the bottom end of the grinding chamber. The bottom of the grinding chamber is in the shape of an inverted frustum of a cone, and the second through-openings are evenly distributed at the bottom of the grinding chamber. The current-limiting sleeve is provided with evenly distributed first through-openings.

[0013] Optionally, the upper half of the current-limiting sleeve is provided with a second annular guard plate adapted to the shape of the bottom of the grinding chamber, and the lower half of the current-limiting sleeve is provided with a concentrated chamber. The first through-openings are arranged in the middle area of the current-limiting sleeve, and the shape of the first through-openings is adapted to the shape of the second through-openings.

[0014] Optionally, the vibration component includes vibration frames fixedly connected to the inner side wall of the grinding chamber and evenly distributed. A feeding chamber is formed at the connecting end between the vibration frame and the inner side wall of the grinding chamber. The bottom of the feeding chamber is provided with an inclined surface facing the inner side wall of the grinding chamber, and a feeding hole is formed at the bottom of the feeding chamber.

[0015] Optionally, a vibration end facing the central axis of the grinding chamber is fixedly connected to the outside of the vibration frame. A groove adapted to the shape of the end of the vibration end is formed on the outside of the transmission head. A wave-shaped deformation area is arranged between the vibration end and the vibration frame.

[0016] Compared with the prior art, the present invention has at least the following beneficial effects:

[0017] In the above solution, by setting the current-limiting component, the solid reagent after being pulverized in the grinding chamber is not added to the dissolution tank for dissolution at one time, but is gradually added into the dissolution tank, so that the reagent entering the dissolution tank can fully contact and dissolve with the solution in the dissolution tank. Compared with the method of adding to the dissolution tank for dissolution at one time, the dissolution efficiency is higher, and the working efficiency of the device is further improved.

[0018] By setting the connection component and the current-limiting component, after the connection component connects the first connecting rod, it can drive the rotation of the first connecting rod, drive other structures associated with the first connecting rod to work synchronously, and then make the current-limiting component, the stirring rod, the pulverizing column and the pulverizing disc on the first connecting rod work synchronously, so that the pulverization of the solid reagent in the grinding chamber, the stirring in the dissolution tank, and the gradual discharge of the pulverized reagent in the grinding chamber can be carried out synchronously. The structures cooperate with each other, complement each other, and jointly realize the technical solution of the whole device.

[0019] By setting the vibrating end and the deformation area in the vibration component, after the solid reagent is crushed, gradually discharged, stirred and dissolved in the grinding chamber, the closing cover can drive the transmission head to move to a position corresponding to the vibrating end, and then the vibrating end is deformed at the deformation area by the rotation and impact of the transmission head, driving the entire vibration component and the grinding chamber to generate high-frequency vibrations, discharging the residual reagent powder particles in the structure of the grinding chamber, and ensuring the accuracy of experimental data.

[0020] By setting the vibration frame, the feeding chamber and the deformation area in the vibration component, it provides positioning for the operation of putting the solid reagent into the grinding chamber, ensures the falling trajectory of the solid reagent after entering the grinding chamber, ensures that the solid reagent can be in the working area of the crushing column and the crushing disc after entering the grinding chamber, avoids the situation that the solid reagent falls into the docking groove and cannot be taken out, ensures that the connection component can work normally, and further avoids the residue of the solid reagent, ensuring the working quality of the device. Brief Description of the Drawings

[0021] The drawings incorporated herein and constituting a part of the specification illustrate embodiments of the present invention and, together with the specification, are further used to explain the principles of the present invention and enable those skilled in the relevant art to implement and use the present invention.

[0022] Figure 1 It is a three-dimensional structural schematic diagram of the first state of the clinical medicinal solid reagent dissolving device;

[0023] Figure 2 It is a three-dimensional structural schematic diagram of the second state of the clinical medicinal solid reagent dissolving device;

[0024] Figure 3 It is a three-dimensional structural schematic diagram of the dissolving tank and the tray;

[0025] Figure 4 It is a schematic diagram of the cooperation structure of the closing cover and the second connecting rod;

[0026] Figure 5 It is a schematic diagram of the inner structure of the grinding chamber;

[0027] Figure 6 It is a three-dimensional structural schematic diagram of the first connecting rod;

[0028] Figure 7 It is a schematic diagram of the partial sectional structure of the flow limiting sleeve;

[0029] Figure 8 It is a sectional view of the grinding chamber;

[0030] Figure 9 For Figure 8 The enlarged structural schematic diagram at position A in

[0031] Figure 10For Figure 8 Schematic enlarged structure diagram at position B in

[0032] Figure 11 Schematic cooperation structure diagram of the drive head and the vibration frame;

[0033] Figure 12 Schematic three-dimensional structure diagram of the vibration frame.

[0034] Reference numerals:

[0035] 1. Fixed seat; 2. First fixing frame; 3. Second fixing frame; 4. Mounting frame; 5. First electric telescopic rod; 6. Second electric telescopic rod; 7. Grinding powder chamber; 8. Sealing cover; 9. Servo motor; 10. Current limiting sleeve; 11. First connecting rod; 12. Stirring rod; 13. Dissolving tank; 14. Tray; 15. Controller; 16. Storage groove; 17. First annular guard plate; 18. Second connecting rod; 19. Drive head; 20. Drive sleeve; 21. Docking groove; 22. Vibration frame; 23. Feeding chamber; 24. Vibration end; 25. Crushing column; 26. Crushing disc; 27. Second annular guard plate; 28. Concentrating chamber; 29. First through opening; 30. Second through opening; 31. Groove; 32. Deformation area; 33. Feeding hole.

[0036] As shown in the figure, in order to clearly show the structure of the embodiments of the present invention, specific structures and devices are marked in the figure. However, this is only for schematic purposes and is not intended to limit the present invention to this specific structure, device and environment. Those of ordinary skill in the art can adjust or modify these devices and environments according to specific needs. Detailed Description of the Embodiment

[0037] The following will describe in detail a clinical medicinal solid reagent dissolving device provided by the present invention with reference to the accompanying drawings and specific embodiments. At the same time, it should be noted here that in order to make the embodiments more detailed, the following embodiments are the best and preferred embodiments. For some well-known technologies, those skilled in the art can also adopt other alternative methods for implementation; moreover, the accompanying drawings are only for more specifically describing the embodiments and are not intended to specifically limit the present invention.

[0038] It should be pointed out that in the specification, when referring to "an embodiment", "embodiment", "exemplary embodiment", "some embodiments", etc., it indicates that the described embodiment may include specific features, structures or characteristics, but not necessarily every embodiment includes such specific features, structures or characteristics. In addition, when combining an embodiment to describe a specific feature, structure or characteristic, implementing such feature, structure or characteristic in combination with other embodiments (whether explicitly described or not) should be within the knowledge of those skilled in the relevant art.

[0039] Generally, terms can be understood, at least in part, from their use in context. For example, depending at least in part on the context, the term "one or more" as used herein can be used to describe any feature, structure, or characteristic in a singular sense, or can be used to describe a combination of features, structures, or characteristics in a plural sense. Additionally, the term "based on" can be understood as not necessarily intended to convey a set of exclusive factors, but rather, depending at least in part on the context, can alternatively allow for the presence of other factors that are not necessarily expressly described.

[0040] It will be understood that the meanings of "on", "above", and "over" in the present invention should be construed in the broadest manner such that "on" not only means "directly on" something, but also includes the meaning of being "on" something with intervening features or layers therebetween, and "above" or "over" not only means "above" or "over" something, but can also include the meaning of being "above" or "over" something with no intervening features or layers therebetween.

[0041] Furthermore, spatial relative terms such as "under", "below", "lower", "above", "upper", etc. may be used herein for convenience of description to describe the relationship of one element or feature to another or other elements or features, as illustrated in the figures. Spatial relative terms are intended to encompass different orientations in the use or operation of the device in addition to the orientation depicted in the figures. The device may be otherwise oriented, and the spatial relative descriptors used herein may be interpreted accordingly.

[0042] As Figures 1 to 12As shown, an embodiment of the present invention provides a clinical medicinal solid reagent dissolving device, including a fixed seat 1. There are a first fixing frame 2 and a second fixing frame 3 fixedly connected to the outside of the fixed seat 1. A grinding chamber 7 is assembled in the second fixing frame 3. Second electric telescopic rods 6 are symmetrically installed at the top of the first fixing frame 2, and first electric telescopic rods 5 are symmetrically installed at the bottom of the first fixing frame 2. An installation frame 4 is fixedly connected to the end of the second electric telescopic rod 6, and a tray 14 is fixedly connected to the end of the first electric telescopic rod 5. A dissolving tank 13 is placed on the tray 14. A first connecting rod 11 is sleeved in the grinding chamber 7. A closing cover 8 is fixedly connected to the bottom of the installation frame 4. A servo motor 9 is arranged on the top of the closing cover 8. The setting of the first fixing frame 2 provides an installation position outside the fixed seat 1 for the first electric telescopic rod 5 and the second electric telescopic rod 6, and provides a stable working environment for the first electric telescopic rod 5 and the second electric telescopic rod 6. The second fixing frame 3 is used to fix the grinding chamber 7 and keep the position of the grinding chamber 7 outside the fixed seat 1 fixed. When the second electric telescopic rod 6 works, it can drive the installation frame 4 and the closing cover 8 to lift, and then realize the opening and closing of the top of the grinding chamber 7 through the closing cover 8, so that the structure in the grinding chamber 7 remains in a closed state during the process of crushing the solid reagent. The first connecting rod 11 can rotate in the grinding chamber 7, and drive each structure in the device to perform corresponding operations during the rotation process, so as to ensure that each structure in the device can operate synchronously, and cooperate to complete the crushing of the solid reagent, the gradual discharge of the crushed solid reagent, and the stirring and mixing of the discharged granular reagent in the dissolving tank 13, so that the entire device can complete the dissolving operation of the solid reagent completely.

[0043] A connecting component is used to associate the servo motor 9 with the first connecting rod 11. The connecting component is respectively connected between the drive shaft of the servo motor 9 and the first connecting rod 11. The connecting component remains connected when the closing cover 8 is closed. At this time, the drive shaft of the servo motor 9 and the first connecting rod 11 are associated through the connecting component. When the servo motor 9 works, it can drive the first connecting rod 11 to rotate through the drive shaft, and then make all other structures related to the first connecting rod 11 be in a working state, realizing the dissolution operation of the solid reagent by the device; A flow-limiting component is used to limit the discharge speed of the crushed solid reagent in the grinding chamber 7. The flow-limiting component is respectively connected between the grinding chamber 7 and the first connecting rod 11. The flow-limiting component works following the rotation of the first connecting rod 11, and gradually releases the crushed solid reagent stored in the grinding chamber 7, so as to control the amount of reagent entering the dissolution tank 13, thereby avoiding the adhesion between the particles of the reagent, increasing the effective surface area of contact between the reagent and the solvent, and accelerating the dissolution speed; A vibration component is used to generate vibration in the grinding chamber 7 to discharge the remaining reagent. The vibration component is connected to the inner side wall of the grinding chamber 7. The setting of the vibration component enables the closing cover 8 to be opened after the device completes the crushing and gradual discharge of the solid reagent, making the structure in the connecting component correspond to the position of the vibration component. Then, through the operation of the servo motor 9, the connecting component touches the vibration component to work, generating high-frequency vibration in the grinding chamber 7, shaking down the solid reagent remaining in the grinding chamber 7, and ensuring that all the solid reagent in the grinding chamber 7 is discharged into the dissolution tank 13 for dissolution.

[0044] In this embodiment, as Figures 1 to 6As shown, a guide rod corresponding to the movement ranges of the mounting frame 4 and the tray 14 is provided on the fixed seat 1. Both the mounting frame 4 and the tray 14 are movably sleeved outside the guide rod. An external controller 15 is fixedly connected to the outside of the fixed seat 1. The controller 15 is electrically connected to the first electric telescopic rod 5, the second electric telescopic rod 6, and the servo motor 9. The controller 15 is used to control the working states of the first electric telescopic rod 5, the second electric telescopic rod 6, and the closing cover 8 in the device, so that they can cooperate with each other, enabling different electrical devices to work in different states of the whole device. The principle and the using process of this controller 15 are the same as those of the prior art, and will not be elaborated here. When the whole device is in the first state, the closing cover 8 is kept open under the action of the second electric telescopic rod 6, and the tray 14 is kept in contact with the bottom of the inner wall of the fixed seat 1 under the action of the first electric telescopic rod 5. The open state of the closing cover 8 exposes the opening at the top of the grinding chamber 7, facilitating the experimenter to add solid reagent raw materials into the grinding chamber 7. And the position of the tray 14 provides enough space between the tray 14 and the stirring rod 12 for the experimenter to place the dissolution tank 13 containing the solvent on the tray 14. Under the control of the controller 15, the whole device can be switched from the first state to the second state. When the whole device is in the second state, both the first electric telescopic rod 5 and the second electric telescopic rod 6 are in the contracted state, the closing cover 8 seals the top of the grinding chamber 7, and the dissolution tank 13 rises with the tray 14 and is sleeved outside the stirring rod 12, and the solvent in the dissolution tank 13 submerges the stirring rod 12, preparing for the crushing and dissolution operations of the solid reagent. One end of the first connecting rod 11 is located inside the grinding chamber 7, and the other end of the first connecting rod 11 extends outside the grinding chamber 7 and is fixedly connected with uniformly distributed stirring rods 12. A crushing column 25 and a crushing disc 26 are fixedly connected to the outside of the area where the first connecting rod 11 is located in the grinding chamber 7. When the whole device is in the second state, through the association of the connecting assembly, when the servo motor 9 works, it can drive the crushing column 25 and the crushing disc 26 on the first connecting rod 11 to rotate and strike and crush the solid reagent, so that the solid reagent can be discharged from the grinding chamber 7 in the form of powder particles, facilitating the subsequent dissolution operation.

[0045] In this embodiment, as Figures 1 to 3As shown, a storage groove 16 adapted to the shape of the bottom of the dissolution tank 13 is formed in the tray 14, and a first annular guard plate 17 surrounding the outside of the storage groove 16 is fixedly connected to the tray 14. Uniformly distributed reinforcing ribs are provided between the outer side wall of the first annular guard plate 17 and the tray 14. The tray 14 is provided to provide a stable working environment for the dissolution tank 13. After the dissolution tank 13 is placed on the tray 14, the bottom of the dissolution tank 13 is sleeved in the storage groove 16 on the tray 14. The first annular guard plate 17 surrounds the outside of the dissolution tank 13, and the structural strength of the first annular guard plate 17 is strengthened by the reinforcing ribs, further ensuring the stability of the dissolution tank 13 after being placed on the tray 14. The lifting of the tray 14 can drive the dissolution tank 13 to produce a corresponding displacement, and by changing the space size between the tray 14 and the stirring rod 12, sufficient space is provided for the taking and placing of the dissolution tank 13, facilitating the placement of the dissolution tank 13 before the dissolution of solid reagents and the taking operation after the completion of reagent dissolution.

[0046] In this embodiment, as Figures 4 to 9 shown, the connection assembly includes a second connecting rod 18 fixedly connected to the outside of the drive shaft of the servo motor 9 and a transmission sleeve 20 fixedly connected to the end of the first connecting rod 11. A transmission head 19 is fixedly connected to the end of the second connecting rod 18. A docking groove 21 adapted to the shape of the transmission head 19 is formed in the transmission sleeve 20. The transmission sleeve 20 is located at one end of the first connecting rod 11 away from the stirring rod 12. The second connecting rod 18 is movably connected to the closing cover 8 through a bearing. A slope is provided at the entrance of the docking groove 21. The bearing between the second connecting rod 18 and the closing cover 8 ensures the rotational movement ability of the second connecting rod 18 below the closing cover 8. When the whole device is in the second state, the transmission head 19 and the transmission sleeve 20 in the connection assembly are mutually docked, so that the second connecting rod 18 and the first connecting rod 11 are in an associated connection state. The slope at the entrance of the docking groove 21 increases the area of the entrance of the docking groove 21, so that the area of the entrance of the docking groove 21 is larger than the end face area of the transmission head 19, facilitating the insertion of the transmission head 19 into the docking groove 21 and easily forming a connection state between the transmission head 19 and the transmission sleeve 20. After the servo motor 9 works and drives the second connecting rod 18 to rotate through its drive shaft, the first connecting rod 11 can be driven to rotate and work through the transmission of the transmission head 19 and the transmission sleeve 20, so that the stirring rod 12, the crushing column 25, and the crushing disk 26 on the first connecting rod 11 all rotate. The rotation of the crushing column 25 and the crushing disk 26 can crush the solid reagents in the grinding chamber 7, and the reagents discharged after crushing enter the dissolution tank 13 and come into contact with the solution and dissolve. The rotation of the stirring rod 12 driven by the first connecting rod 11 can also stir the solution in the dissolution tank 13, further increasing the contact area between the solution and the crushed reagents and further accelerating the dissolution rate of the solid reagents.

[0047] In this embodiment, as Figures 5 to 10 shown, the current-limiting component includes a current-limiting sleeve 10 fixedly connected to the outside of the first connecting rod 11 and a second through-opening 30 formed at the bottom end of the grinding powder chamber 7. The bottom of the grinding powder chamber 7 is in the shape of an inverted frustum of a cone. The second through-openings 30 are evenly distributed at the bottom of the grinding powder chamber 7. The current-limiting sleeve 10 is provided with evenly distributed first through-openings 29. The upper half of the current-limiting sleeve 10 is provided with a second annular guard plate 27 adapted to the shape of the bottom of the grinding powder chamber 7, and the lower half of the current-limiting sleeve 10 is provided with a concentration chamber 28. The first through-openings 29 are arranged in the middle area of the current-limiting sleeve 10, and the shape of the first through-openings 29 is adapted to the shape of the second through-openings 30. The second annular guard plate 27 on the upper half of the current-limiting sleeve 10 is sleeved on the outside of the bottom end of the grinding powder chamber 7 to enhance the sealing effect of the current-limiting sleeve 10 on the bottom end of the grinding powder chamber 7. The setting of the concentration chamber 28 forms a shield for the solid reagent powder particles at the bottom of the current-limiting sleeve 10, so that the powder particles can be more concentratedly put into the dissolution tank 13 after being discharged through the current-limiting sleeve 10. When the whole device is in the second state, the rotation of the first connecting rod 11 can not only drive the crushing column 25 and the crushing disc 26 to crush the solid reagent in the grinding powder chamber 7, but also drive the current-limiting sleeve 10 to rotate. Since the first through-openings 29 are evenly distributed on the current-limiting sleeve 10 and the second through-openings 30 are formed at the bottom of the grinding powder chamber 7, the rotation of the current-limiting sleeve 10 will cause the first through-openings 29 and the second through-openings 30 to alternately correspond to each other, and then the bottoms of the grinding powder chamber 7 and the current-limiting sleeve 10 will be intermittently in an open state due to the rotation of the first connecting rod 11, so that the solid reagent that has been crushed in the grinding powder chamber 7 and the particle size of which is smaller than the opening sizes of the first through-openings 29 and the second through-openings 30 can be gradually discharged, rather than being poured into the dissolution tank 13 all at once after being crushed. In this way, the crushed solid reagent can gradually contact the solution in the dissolution tank 13, so that the reagents entering the dissolution tank 13 can all fully contact the solution in the dissolution tank 13, and a small amount of reagent is added gradually, and the solute concentration in the solution gradually increases, avoiding the problem of too high local concentration. Avoiding the enhancement of the interaction between solute molecules due to too high local concentration and inhibiting the dissolution process, and cooperating with the stirring of the stirring rod 12 in the dissolution tank 13 to enable the solid reagent to quickly complete the dissolution process.

[0048] In this embodiment, as Figures 11 to 12As shown in the figure, the vibration assembly includes vibration frames 22 fixedly connected to the inner side wall of the grinding chamber 7 and evenly distributed. A feeding chamber 23 is provided at the connection end between the vibration frame 22 and the inner side wall of the grinding chamber 7. The bottom of the feeding chamber 23 is provided with an inclined surface facing the inner side wall of the grinding chamber 7, and a feeding hole 33 is opened at the bottom of the feeding chamber 23. The opening of the feeding chamber 23 can provide positioning for the experimenter to put solid reagents into the grinding chamber 7. The solid reagents put in from the feeding chamber 23 leak into the grinding chamber 7 through the feeding hole 33, providing guidance and limitation for the entry of the solid reagents and preventing the solid reagents from entering the docking groove 21 on the transmission sleeve 20. An outer part of the vibration frame 22 is fixedly connected with a vibration end 24 facing the central axis of the grinding chamber 7. A groove 31 adapted to the shape of the end of the vibration end 24 is opened on the outer part of the transmission head 19. A wave-shaped deformation area 32 is provided between the vibration end 24 and the vibration frame 22. The setting of the deformation area 32 makes the thickness value of the vibration end 24 at the deformation area 32 smaller than the thickness values of other areas on the vibration frame 22 and the vibration end 24, with lower strength. Then, when the vibration end 24 is hit during the rotation of the transmission head 19, it can deform more easily at the deformation area 32, causing the entire vibration frame 22 and the grinding chamber 7 to generate corresponding vibrations. When the reagents stored in the grinding chamber 7 are completely pulverized and gradually discharged into the dissolution tank 13, the dissolution tank 13 remains sleeved outside the stirring rod 12. The first electric telescopic rod 5 drives the mounting frame 4 and the sealing cover 8 to generate displacement, so that the position of the sealing cover 8 corresponds to the position of the first state of the whole device. The first through-opening 29 on the current-limiting sleeve 10 remains corresponding to the second through-opening 30 at the bottom of the grinding chamber 7, keeping the bottom end of the grinding chamber 7 in an open state. At this time, the transmission head 19 at the end of the second connecting rod 18 is docked with the end of the vibration end 24 on the vibration frame 22, and the end of the vibration end 24 is embedded in the groove 31 on the transmission head 19. In this way, when the servo motor 9 continues to work and drives the transmission head 19 to rotate through the second connecting rod 18, it will cause the vibration end 24 to generate a bending deformation at the deformation area 32. Then, through the impact of the transmission head 19 on the vibration end 24, the vibration frame 22 and the entire grinding chamber 7 generate corresponding high-frequency vibrations, shaking down the residual solid reagents in the grinding chamber 7, so that the solid reagents for dissolution can completely enter the dissolution tank 13 for dissolution, effectively reducing the residue of the reagents in the device and ensuring the accuracy of experimental data.

[0049] This invention covers any substitutions, modifications, equivalent methods, and solutions made within the essence and scope of this invention. To enable the public to have a thorough understanding of this invention, specific details are described in detail in the following preferred embodiments of this invention. However, those skilled in the art can fully understand this invention even without the description of these details. Additionally, to avoid unnecessary confusion to the essence of this invention, well-known methods, processes, procedures, components, and circuits are not described in detail.

[0050] The above are only the preferred embodiments of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and modifications can be made, and these improvements and modifications should also be regarded as the protection scope of the present invention.

Claims

1. A clinical pharmaceutical solid reagent dissolving device, characterized in that: The invention comprises a fixing seat, the outside of which is fixedly connected with a first fixing frame and a second fixing frame, a grinding chamber is installed in the second fixing frame, a second electric telescopic rod is symmetrically installed at the top of the first fixing frame, a first electric telescopic rod is symmetrically installed at the bottom of the first fixing frame, a mounting frame is fixedly connected to the end of the second electric telescopic rod, a tray is fixedly connected to the end of the first electric telescopic rod, a dissolving tank is placed on the tray, a first connecting rod is sleeved in the grinding chamber, a closing cover is fixedly connected to the bottom of the mounting frame, and a servo motor is arranged on the top of the closing cover; A connecting assembly, used to associate the servo motor with the first connecting rod, the connecting assembly being connected to the driving shaft of the servo motor and the first connecting rod respectively; A flow limiting component, used for limiting the discharge speed of the crushed solid reagent in the grinding chamber, wherein the flow limiting component is respectively connected to the grinding chamber and the first connecting rod; A vibration assembly, used to generate vibration in the grinding chamber to discharge the residual reagent, the vibration assembly being connected to the inner side wall of the grinding chamber; The connecting assembly includes a second connecting rod fixedly connected to the outside of the driving shaft of the servo motor and a transmission sleeve fixedly connected to the end of the first connecting rod, the end of the second connecting rod is fixedly connected to a transmission head, and the transmission sleeve is provided with a docking groove adapted to the shape of the transmission head; The transmission sleeve is located at one end of the first connecting rod away from the stirring rod, the second connecting rod is movably connected to the closing cover via a bearing, and an inclined surface is provided at the entrance of the docking groove; The current limiting assembly includes a current limiting sleeve fixedly connected to the outside of the first connecting rod and a second through opening opened at the bottom end of the grinding chamber, the bottom of the grinding chamber is in an inverted truncated cone shape, the second through openings are evenly distributed at the bottom of the grinding chamber, and the current limiting sleeve is provided with evenly distributed first through openings; The upper part of the limiting sleeve is provided with a second annular guard plate adapted to the shape of the bottom of the grinding chamber, and the lower part of the limiting sleeve is provided with a concentration chamber, the first through opening is provided in the middle area of ​​the limiting sleeve, and the shape of the first through opening is adapted to the shape of the second through opening; The vibration assembly includes a vibration frame fixedly connected to the inner side wall of the grinding chamber and evenly distributed, a material injection chamber is provided at the connection end between the vibration frame and the inner side wall of the grinding chamber, a slope facing the inner side wall of the grinding chamber is provided at the bottom of the material injection chamber, and a material inlet hole is provided at the bottom of the material injection chamber; The outside of the vibration frame is fixedly connected with a vibration end facing the central axis of the grinding chamber, the outside of the transmission head is provided with a groove matched with the end shape of the vibration end, and a wavy deformation zone is provided between the vibration end and the vibration frame.

2. The clinical pharmaceutical solid reagent dissolving device according to claim 1, characterized in that: The fixing seat is provided with a guide rod corresponding to the movable range of the mounting frame and the tray. The mounting frame and the tray are movably mounted on the outside of the guide rod. A controller is fixedly connected to the outside of the fixing seat. The controller is electrically connected to the first electric telescopic rod, the second electric telescopic rod and the servo motor.

3. The clinical pharmaceutical solid reagent dissolving device according to claim 2, characterized in that: One end of the first connecting rod is located inside the grinding chamber, and the other end of the first connecting rod extends to the outside of the grinding chamber and is fixedly connected to evenly distributed stirring rods, and the first connecting rod is fixedly connected to a crushing column and a crushing disk outside the area where the first connecting rod is located in the grinding chamber.

4. The clinical pharmaceutical solid reagent dissolving device according to claim 3, characterized in that: The tray is provided with a storage groove matched with the bottom shape of the dissolving tank, and the tray is fixedly connected with a first annular guard plate surrounding the outside of the storage groove, and evenly distributed reinforcing ribs are arranged between the outer wall of the first annular guard plate and the tray.

Images