Temperature control device of liquid chromatogram tandem mass spectrometer

Abstract

The invention relates to the technical field of liquid chromatography-mass spectrometers, and discloses a temperature control device of a liquid chromatography tandem mass spectrometer, which comprises a column oven, a partition plate is arranged in the column oven, the partition plate divides the interior of the column oven into an operation chamber and a refrigeration chamber, a heating box and a heat exchange assembly are arranged in the operation chamber, and the refrigeration chamber is communicated with the heating box. A refrigeration box is arranged in the refrigeration chamber; the heat exchange assembly comprises a fixing frame fixed to the partition plate, a sleeve is arranged on one side of the fixing frame, fixing plates are oppositely arranged at the two ends of the sleeve, the fixing plates are fixedly connected to the fixing frame, the chromatographic columns are fixed to the peripheral side of the sleeve, a plurality of air supply outlets are formed in the peripheral side wall of the sleeve, one end of the sleeve communicates with the heating box, and a cold air pipe is rotationally connected into the sleeve. The end, away from the heating box, of the cold air pipe extends out of the sleeve and communicates with the refrigerating box. Switching of cold air and hot air is achieved through the heat exchange assembly, accurate and rapid regulation and control of the temperature in the chromatographic column are achieved, and therefore the separation effect of the chromatographic column is improved.

Description

Technical Field

[0001] The present application relates to the technical field of temperature control devices, and in particular to a temperature control device for a liquid chromatography-tandem mass spectrometer. Background Art

[0002] Liquid chromatography-mass spectrometry combines the ability of liquid chromatography to effectively separate thermally unstable and high-boiling point compounds with the strong component identification capability of mass spectrometer. It is an effective means of separating and analyzing complex organic mixtures.

[0003] At present, the traditional column oven is mainly used to keep the chromatographic column warm. When the chromatographic column is placed inside the column oven, due to the large internal space of the column oven and the slow temperature control speed of the entire column, the temperature of the chromatographic column cannot be controlled timely and accurately, resulting in poor separation effect of the chromatographic column. Summary of the invention

[0004] In order to improve the problem that the existing column oven cannot timely and accurately control the temperature of the chromatographic column, resulting in poor separation effect of the chromatographic column, the present application provides a temperature control device for a liquid chromatography tandem mass spectrometer.

[0005] The present application provides a temperature control device for a liquid chromatography tandem mass spectrometer, which adopts the following technical solution: A temperature control device for a liquid chromatography tandem mass spectrometer, comprising a column temperature box, wherein a partition is arranged in the column temperature box, wherein the partition divides the interior of the column temperature box to form an operation chamber and a refrigeration chamber, wherein a heating box and a heat exchange component are arranged in the operation chamber, and a refrigeration box is arranged in the refrigeration chamber; The heat exchange component comprises a fixing frame fixed on the partition, a sleeve is provided on one side of the fixing frame, fixing plates are relatively provided at two ends of the sleeve, the fixing plate is fixedly connected to the fixing frame, the chromatographic column is fixed on the peripheral side of the sleeve, a plurality of air supply ports are provided on the peripheral side wall of the sleeve, one end of the sleeve is communicated with the heating box, a cold air pipe is rotatably connected in the sleeve, one end of the cold air pipe away from the heating box extends to the outside of the sleeve and is communicated with the refrigeration box; ventilation ducts corresponding to the air supply ports are provided on the cold air pipe, and cold air channels are provided on the cold air pipe between adjacent ventilation channels, wherein the air supply ports are connected to the ventilation duct or the cold air channel by rotating the cold air pipe; a driving component for driving the cold air pipe to rotate is provided on the partition; A heat-insulating cover for covering the chromatographic column is arranged on the peripheral side of the sleeve.

[0006] By adopting the above technical scheme, the chromatographic column is first fixed on the side of the casing, and a heat-insulating cover is arranged on the side of the chromatographic column, so that the chromatographic column is isolated from the external environment and is placed in a closed space, thereby reducing the space for temperature control, conveniently and quickly controlling the temperature of the chromatographic column, and reducing energy consumption; when heating, the driving component drives the cold air pipe to rotate, so that the air supply port is connected with the ventilation duct, and the hot air in the heating box is blown out through the air supply port to heat the chromatographic column fixed on the side of the casing; when cooling, the cold air pipe is rotated, so that the air supply port is connected with the cold air channel, and the cold air in the refrigeration box flows to the air supply port through the cold air channel, thereby quickly cooling the temperature control room, and improving the separation effect of the chromatographic column by accurately and quickly controlling the temperature in the chromatographic column.

[0007] Optionally, the heat preservation cover includes a first shield and a second shield hinged to each other, and the first shield and the second shield are respectively rotatably connected to fixed plates located at both ends of the sleeve, and bosses are provided on the fixed plates, and the inner walls of the first shield and the second shield at both ends abut against the peripheral side walls of the bosses; return air channels are provided on the inner walls of the first shield and the second shield, and the first shield is connected to each other at the hinge of the first shield and the second shield, and a return air port is provided on the first shield; a return air pipe is passed through the fixed plate close to the side of the heating box, and the return air pipe is connected to the return air port, and the end of the return air pipe away from the fixed plate is connected to the heating box.

[0008] By adopting the above technical solution, the space for temperature control is reduced by the heat preservation cover, which facilitates the temperature control. The circulation of gas in the heat preservation cover is realized through the return air channel, which reduces energy consumption and realizes fast and accurate temperature control.

[0009] Optionally, a locking assembly is provided between the first shield and the second shield, and the locking assembly includes a lock buckle provided on the first shield, and a lock hook rotatably connected to the second shield, the lock hook cooperates with the lock buckle, and the outer side wall of the second shield is provided with a handle connected to the lock hook.

[0010] By adopting the above technical solution, the handle is rotated to drive the lock hook to rotate, thereby achieving locking or opening of the lock hook and the lock buckle, and closing or opening of the first shield and the second shield.

[0011] Optionally, a fixing assembly is provided between the sleeve and the chromatographic column, the fixing assembly comprising a first fixing plate and a second fixing plate, the first fixing plate being rotatably sleeved on one end of the sleeve, the second fixing plate being rotatably and slidably sleeved on the other end of the sleeve, an adjusting rod and a plurality of guide rods being provided between the first fixing plate and the second fixing plate, one end of the adjusting rod being rotatably connected to the first fixing plate, the other end of the adjusting rod being threadedly connected to the second fixing plate, one end of the guide rod being fixedly connected to the first fixing plate, and the other end of the guide rod being slidably connected to the second fixing plate; a plurality of placement grooves are provided on the circumferential sides of the first fixing plate and the second fixing plate, and elastic clips for clamping the chromatographic column are fixed to the placement grooves.

[0012] By adopting the above technical solution, the chromatographic column is fixed to the first fixed plate and the second fixed plate by the elastic clip, and the installation and removal of the chromatographic column are facilitated by rotating the directions of the first fixed plate and the second fixed plate at the same time. The spacing between the first fixed plate and the second fixed plate is adjusted by rotating the adjustment rod, so that the fixing assembly is adapted to chromatographic columns of different sizes.

[0013] Optionally, the cold air duct includes an outer tube and an inner tube, one end of the outer tube and the inner tube are closed and connected, the ventilation duct runs through and connects the side walls of the outer tube and the inner tube, and the cold air channel is located between the outer tube and the inner tube.

[0014] By adopting the above technical solution, when temperature is controlled, an isolation barrier is formed by the outer tube and the inner tube, and different gas passages are formed when the temperature is increased or decreased, which facilitates temperature control.

[0015] Optionally, a refrigeration plate is provided in the refrigeration box, a radiator is provided outside the refrigeration box, an external circulation pipe is connected to the refrigeration box, the external circulation pipe passes through and is connected to the partition, one end of the external circulation pipe is rotatably connected to the outer pipe, and a first fan is provided at the end of the external circulation pipe away from the outer pipe; an inner circulation pipe is provided in the outer circulation pipe, one end of the inner circulation pipe is rotatably connected to the inner pipe, and the other end of the inner circulation pipe passes through the outer circulation side wall and is connected to the refrigeration box.

[0016] By adopting the above technical solution, the cold air is transported out from the outer circulation pipe through the first fan, and the gas is returned to the refrigeration box through the inner circulation pipe for cooling, thereby achieving rapid temperature reduction.

[0017] Optionally, baffles are provided at the ends of the connection between the inner circulation pipe and the inner pipe, and a plurality of through holes are opened on the baffles, wherein when the cold air duct rotates, the baffle on one side blocks the through holes on the baffle on the other side, or the through holes on the baffles on both sides are connected, so as to realize the connection or blocking of the inner circulation pipe and the inner pipe.

[0018] By adopting the above technical solution, when the cold air duct rotates, the baffle on one side blocks the through hole on the baffle on the other side, or the through holes on the baffles on both sides are connected, so that the inner circulation pipe and the inner pipe are connected or blocked, and gas circulation or isolation is achieved.

[0019] Optionally, the driving assembly includes a driving motor fixed on the partition, the output end of the driving motor is connected to a first gear, and the cold air duct is provided with a second gear that is transmission-connected to the first gear; a limiting groove is provided on the sleeve, and a limiting block that slides along the limiting groove is provided on the outer wall of the cold air duct.

[0020] By adopting the above technical scheme, the first gear is driven to rotate by the driving motor, thereby driving the rotation of the cold air duct, so that the air supply port is connected with the ventilation duct or the cold air channel, and the limit block slides along the limit groove to limit the rotation angle of the cold air duct, thereby ensuring that after the cold air duct rotates, when heating, the air supply port is connected with the ventilation duct and the cold air channel is blocked, or, when cooling, the air supply port is connected with the cold air channel and the ventilation duct is blocked, thereby forming different gas circuits to achieve rapid temperature control.

[0021] Optionally, an air inlet is provided on the heating box, an electric heating element is provided in the heating box, and a second fan is provided at the connection position of the sleeve in the heating box.

[0022] By adopting the above technical solution, the gas in the heating box is heated by the electric heating element, and the gas in the heating box is blown out by the second fan, thereby realizing the transportation of hot gas.

[0023] Optionally, a control panel is provided on the column oven, a temperature sensor for monitoring the temperature inside the heat preservation cover is provided on the fixed plate, the control panel is electrically connected to the temperature sensor, and a box door is provided on one side of the operating chamber.

[0024] By adopting the above technical solution, the temperature parameters are set through the control panel, and the temperature is detected by the temperature sensor to achieve automatic temperature control.

[0025] In summary, the present application includes at least one of the following beneficial technical effects: through the heat exchange component, the gas circulation in the heating box or the refrigeration box is realized, the temperature in the insulation cover is regulated, and the temperature in the chromatographic column is accurately and quickly regulated, thereby improving the separation effect of the chromatographic column. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a structural schematic diagram of the temperature control device of the liquid chromatography tandem mass spectrometer of the present application.

[0027] Figure 2 It is a schematic diagram of the internal structure of the temperature control device of the liquid chromatography tandem mass spectrometer of the present application.

[0028] Figure 3 It is a cross-sectional view of the temperature control device of the liquid chromatography tandem mass spectrometer of the present application.

[0029] Figure 4 yes Figure 3 Schematic diagram of the structure with the A part in the middle enlarged.

[0030] Figure 5 It is a structural schematic diagram of the heat exchange component of this application.

[0031] Figure 6 It is a cross-sectional view of the heat exchange component of the present application.

[0032] Figure 7 It is a structural schematic diagram of the thermal insulation cover of this application.

[0033] Figure numerals: 1, column temperature box; 11, partition; 12, operation chamber; 13, refrigeration chamber; 14, box door; 15, control panel; 2, heating box; 21, air inlet; 22, electric heating element; 23, second fan; 3, refrigeration box; 31, refrigeration plate; 33, radiator; 34, external circulation pipe; 35, internal circulation pipe; 36, baffle; 37, through hole; 38, first fan; 4, heat exchange component; 41, fixing frame; 42, sleeve; 411, air supply port; 412, limit groove; 43, fixing plate; 431, boss; 432, return air pipe; 44, cold air pipe ; 441. Outer tube; 442. Inner tube; 443. Cold air channel; 444. Ventilation duct; 445. Convex ring; 45. Limit block; 48. Second gear; 49. End cover; 5. Fixing assembly; 51. First fixing plate; 511. Placement slot; 52. Second fixing plate; 53. Adjustment rod; 54. Guide rod; 55. Elastic clip; 6. Insulation cover; 61. First protective cover; 62. Second protective cover; 63. Return air channel; 64. Return air port; 65. Lock hook; 66. Lock buckle; 67. Handle; 7. Drive assembly; 71. Drive motor; 72. First gear; 8. Chromatographic column. DETAILED DESCRIPTION

[0034] Embodiments of the present application are described in detail below, examples of which are shown in the accompanying drawings.

[0035] In the description of this specification, the description with reference to the terms "certain embodiments", "one embodiment", "some embodiments", "illustrative embodiments", "examples", "specific examples", or "some examples" means that the specific features, structures, materials, or characteristics described in conjunction with the embodiments or examples are included in at least one embodiment or example of the present application. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described may be combined in any one or more embodiments or examples in a suitable manner.

[0036] The present application embodiment discloses a temperature control device for a liquid chromatography tandem mass spectrometer, referring to Figure 1 and Figure 2 , including a column temperature box 1, a partition 11 is installed in the column temperature box 1, and the partition 11 divides the inside of the column temperature box 1 into an operation chamber 12 and a refrigeration chamber 13. A heating box 2 and a heat exchange component 4 are arranged in the operation chamber 12, and a refrigeration box 3 is arranged in the refrigeration chamber 13; Reference Figure 2-6 The heat exchange component 4 includes a fixing frame 41 fixed on the partition 11, a sleeve 42 is arranged on one side of the fixing frame 41, and fixing plates 43 are arranged at opposite ends of the sleeve 42, and the fixing plates 43 are fixedly connected to the fixing frame 41, and the chromatographic column 8 is fixed on the peripheral side of the sleeve 42, and a plurality of air supply ports 411 are opened on the peripheral side wall of the sleeve 42, and the air supply ports 411 are evenly spaced along the peripheral side of the sleeve 42, and one end of the sleeve 42 is connected to the heating box 2, and a cold air pipe 44 is rotatably connected in the sleeve 42, and the end of the cold air pipe 44 away from the heating box 2 extends to the outside of the sleeve 42 and is connected to the refrigeration box 3; the cold air pipe 44 is opened The ventilation ducts 444 correspond to the air supply ports 411 one by one, and the cold air ducts 44 are provided with cold air ducts 443 between the adjacent ventilation ducts 444. The cold air ducts 44 include an outer tube 441 and an inner tube 442. One end of the outer tube 441 and the inner tube 442 are closed and connected. The ventilation ducts 444 penetrate and connect the side walls of the outer tube 441 and the inner tube 442. The cold air ducts 443 are located between the outer tube 441 and the inner tube 442. The air supply ports 411 are connected to the ventilation ducts 444 or the cold air ducts 443 by rotating the cold air ducts 44. The partition 11 is provided with a driving component 7 for driving the cold air duct 44 to rotate. A heat-insulating cover 6 for covering the chromatographic column 8 is arranged around the sleeve 42. The heat-insulating cover 6 is made of heat-insulating material to reduce heat loss.

[0037] Reference Figure 2 , Figure 3 and Figure 7 The heat preservation cover 6 includes a first protective cover 61 and a second protective cover 62 which are hinged to each other. The first protective cover 61 and the second protective cover 62 are of arc-shaped hollow plate-like structures. The first protective cover 61 and the second protective cover 62 are respectively rotatably connected to the fixed plates 43 located at both ends of the sleeve. A boss 431 is arranged on the fixed plate 43. The inner side walls of the first protective cover 61 and the second protective cover 62 at both ends abut against the peripheral side walls of the boss 431. The inner side walls of the first protective cover 61 and the second protective cover 62 are both provided with a return air channel 63, and the first protective cover 61 and the second protective cover 62 are connected to each other at the hinged joint. A return air port 64 is provided on the first protective cover 61. A return air pipe 432 is passed through the fixed plate 43 on the side close to the heating box 2. The return air pipe 432 is connected to the return air port 64, and the end of the return air pipe 432 away from the fixed plate 43 is connected to the heating box 2.

[0038] A locking assembly is provided between the first shield 61 and the second shield 62, and the locking assembly includes a lock catch 66 provided on the first shield 61, and a lock hook 65 rotatably connected to the second shield 62, the lock hook 65 cooperates with the lock catch 66, and a handle 67 connected to the lock hook 65 is provided on the outer side wall of the second shield 62. By rotating the handle 67, the lock hook 65 is driven to rotate, so that the lock hook 65 and the lock catch 66 are locked or opened, and the first shield 61 and the second shield 62 are closed or opened.

[0039] Reference Figure 3 , Figure 5 and Figure 6 A fixing assembly 5 is arranged between the sleeve 42 and the chromatographic column 8, and the fixing assembly 5 includes a first fixing plate 51 and a second fixing plate 52. The first fixing plate 51 is rotatably sleeved on one end of the sleeve 42, and the second fixing plate 52 is rotatably and slidably sleeved on the other end of the sleeve 42. An adjusting rod 53 and a plurality of guide rods 54 are arranged between the first fixing plate 51 and the second fixing plate 52. One end of the adjusting rod 53 is rotatably connected to the first fixing plate 51, and the other end of the adjusting rod 53 is threadedly connected to the second fixing plate 52. One end of the guide rod 54 is fixedly connected to the first fixing plate 51, and the other end of the guide rod 54 is slidably connected to the second fixing plate 52. A plurality of placement grooves 511 are provided on the circumferential sides of the first fixing plate 51 and the second fixing plate 52, and an elastic clip 55 for clamping the chromatographic column 8 is fixed to the placement groove 511.

[0040] When in use, the chromatographic column 8 is fixed to the first fixing plate 51 and the second fixing plate 52 by the elastic clip 55. By rotating the directions of the first fixing plate 51 and the second fixing plate 52 at the same time, the installation and removal of the chromatographic column 8 are facilitated. By rotating the adjustment rod 53 to adjust the distance between the first fixing plate 51 and the second fixing plate 52, the fixing assembly 5 can adapt to chromatographic columns 8 of different sizes.

[0041] A refrigeration plate 31 is arranged in the refrigeration box 3, a radiator 33 is arranged outside the refrigeration box 3, an external circulation pipe 34 is connected to the refrigeration box 3, the external circulation pipe 34 passes through and is connected to the partition 11, one end of the external circulation pipe 34 is rotatably connected to the outer pipe 441, and a first fan 38 is arranged at the end of the external circulation pipe 34 away from the outer pipe 441; an internal circulation pipe 35 is arranged in the external circulation pipe 34, one end of the internal circulation pipe 35 is rotatably connected to the inner pipe 442, and the other end of the internal circulation pipe 35 passes through the external circulation side wall and is connected to the refrigeration box 3.

[0042] An end cover 49 is provided at the connection between the outer tube 441 and the outer circulation tube 34 , a convex ring 445 is provided at the end of the outer tube 441 , the end cover 49 is sleeved on the outer tube 441 , one end of the end cover 49 abuts against the side of the convex ring 445 , and the end cover 49 is threadedly connected to the inner wall of the outer circulation tube 34 .

[0043] Baffles 36 are provided at the ends of the connection between the inner circulation pipe 35 and the inner pipe 442, and a plurality of through holes 37 are opened on the baffles 36. When the cold air pipe 44 rotates, the baffles 36 on one side block the through holes 37 on the baffles 36 on the other side, or the through holes 37 on the baffles 36 on both sides are connected, so that the inner circulation pipe 35 and the inner pipe 442 are connected or blocked.

[0044] The driving assembly 7 includes a driving motor 71 fixed on the partition 11, the output end of the driving motor 71 is connected to the first gear 72, and the cold air duct 44 is provided with a second gear 48 which is transmission-connected to the first gear 72; a limiting groove 412 is provided on the sleeve 42, and a limiting block 45 which slides along the limiting groove 412 is provided on the outer wall of the cold air duct 44.

[0045] The heating box 2 is provided with an air inlet 21, and an electric heating element 22 is provided in the heating box 2. The electric heating element 22 can be a heating plate, a heating resistor, etc. The heating box 2 is provided with a second fan 23 at the connection of the sleeve 42. The electric heating element 22 heats the gas in the heating box 2, and the second fan 23 is used to blow the gas in the heating box 2 out, so as to realize the transportation of hot gas.

[0046] A control panel 15 is installed on the column oven 1 , a temperature sensor for monitoring the temperature in the heat preservation cover 6 is arranged on the fixing plate 43 , the control panel 15 is electrically connected to the temperature sensor, and a box door 14 is arranged on one side of the operation chamber 12 .

[0047] The implementation principle of the temperature control device of a liquid chromatography tandem mass spectrometer in an embodiment of the present application is: according to the size of the chromatographic column 8, the adjustment rod 53 is rotated to adjust the distance between the first fixed disk 51 and the second fixed disk 52; the chromatographic column 8 is attached to the first fixed disk 51 and the second fixed disk 52 by the elastic clip 55, and the first protective cover 61 and the second protective cover 62 are closed.

[0048] When the temperature rises, the driving motor 71 drives the cold air pipe 44 to rotate, so that the ventilation duct 444 is connected to the air supply port 411, the cold air channel 443 is blocked, and the through hole 37 on the baffle 36 is blocked, so that the inner tube 442 and the inner circulation tube 35 are blocked, and the hot air flows from the heating box 2 through the sleeve 42, the inner tube 442 and the ventilation duct 444 in turn, and finally flows out from the air supply port 411 to heat the chromatographic column 8. The hot air then flows back to the heating box 2 through the return air channel 63 and the return air pipe 432, forming a closed circulation channel, realizing the recycling of hot air and reducing heat loss.

[0049] When cooling, the electric heating element 22 is powered off, and the driving motor 71 drives the cold air pipe 44 to rotate, so that the air supply port 411 is connected with the cold air channel 443, the ventilation channel 444 is blocked, and the inner tube 442 is connected with the inner circulation pipe 35. The cold air in the refrigeration box 3 is transported from the outer circulation pipe 34 to the cold air channel 443, and then to the air supply port 411, and then cools the chromatographic column 8. The cold air then flows to the heating box 2 through the return air channel 63 and the return air pipe 24, and then flows to the refrigeration box 3 through the sleeve 42, the inner tube 442 and the inner circulation pipe 35, forming a closed channel to achieve rapid cooling.

[0050] Although the embodiments of the present application have been shown and described above, it can be understood that the above embodiments are exemplary and cannot be understood as limitations on the present application. Ordinary technicians in this field can change, modify, replace and modify the above embodiments within the scope of the present application.

Claims

1. A temperature control device for a liquid chromatography-tandem mass spectrometer, comprising a column oven (1), characterized in that: The column temperature box (1) is provided with a partition (11), the partition (11) divides the interior of the column temperature box (1) to form an operation chamber (12) and a refrigeration chamber (13), the operation chamber (12) is provided with a heating box (2) and a heat exchange component (4), and the refrigeration chamber (13) is provided with a refrigeration box (3); The heat exchange component (4) comprises a fixing frame (41) fixed on the partition (11), a sleeve (42) is arranged on one side of the fixing frame (41), fixing plates (43) are arranged opposite to each other at two ends of the sleeve (42), the fixing plates (43) are fixedly connected to the fixing frame (41), the chromatographic column is fixed on the peripheral side of the sleeve (42), a plurality of air supply ports (411) are opened on the peripheral side wall of the sleeve (42), one end of the sleeve (42) is connected to the heating box (2), a cold air pipe (44) is rotatably connected inside the sleeve (42), and the cold air pipe (44) 44) extends from one end of the heating box (2) to the outside of the sleeve (42) and is connected to the refrigeration box (3); the cold air pipe (44) is provided with ventilation ducts (444) corresponding to the air supply ports (411) one by one, and the cold air pipe (44) is provided with cold air channels (443) between adjacent ventilation channels (444), wherein the air supply ports (411) are connected to the ventilation channels (444) or the cold air channels (443) by rotating the cold air pipe (44); the partition (11) is provided with a driving component (7) for driving the cold air pipe (44) to rotate; The cold air pipe (44) comprises an outer pipe (441) and an inner pipe (442); one end of the outer pipe (441) and the inner pipe (442) are closed and connected; the ventilation passage (444) penetrates and connects the side walls of the outer pipe (441) and the inner pipe (442); and the cold air channel (443) is located between the outer pipe (441) and the inner pipe (442); A heat-insulating cover (6) for covering the chromatographic column is arranged on the peripheral side of the sleeve (42).

2. The temperature control device of liquid chromatography tandem mass spectrometer according to claim 1, characterized in that: The heat-insulating cover (6) comprises a first shield (61) and a second shield (62) which are hinged to each other. The first shield (61) and the second shield (62) are respectively rotatably connected to fixing plates (43) located at two ends of the sleeve. The fixing plates (43) are provided with bosses (431). The inner side walls at two ends of the first shield (61) and the second shield (62) abut against the peripheral side walls of the bosses (431). ) are provided with return air channels (63) on the inner walls, and are interconnected at the hinged joint of the first protective cover (61) and the second protective cover (62), and a return air port (64) is provided on the first protective cover (61); a return air pipe (432) is passed through and connected to the fixed plate (43) on the side close to the heating box (2), and the return air pipe (432) is connected to the return air port (64), and the end of the return air pipe (432) away from the fixed plate (43) is connected to the heating box (2).

3. The temperature control device of liquid chromatography tandem mass spectrometer according to claim 2, characterized in that: A locking assembly is provided between the first shield (61) and the second shield (62), the locking assembly comprising a lock catch (66) provided on the first shield (61), and a lock hook (65) rotatably connected to the second shield (62), the lock hook (65) cooperating with the lock catch (66), and a handle (67) connected to the lock hook (65) is provided on the outer side wall of the second shield (62).

4. The temperature control device of liquid chromatography tandem mass spectrometer according to claim 1, characterized in that: A fixing assembly (5) is arranged between the sleeve (42) and the chromatographic column, and the fixing assembly (5) comprises a first fixing plate (51) and a second fixing plate (52), wherein the first fixing plate (51) is rotatably sleeved on one end of the sleeve (42), and the second fixing plate (52) is rotatably and slidably sleeved on the other end of the sleeve (42), and an adjusting rod (53) and a plurality of guide rods (54) are arranged between the first fixing plate (51) and the second fixing plate (52), and one end of the adjusting rod (53) is The adjusting rod (53) is rotatably connected to the first fixed disk (51), the other end of the adjusting rod (53) is threadedly connected to the second fixed disk (52), one end of the guiding rod (54) is fixedly connected to the first fixed disk (51), and the other end of the guiding rod (54) is slidably connected to the second fixed disk (52); a plurality of placement grooves (511) are provided on the circumference of the first fixed disk (51) and the second fixed disk (52), and the placement grooves (511) are fixed with elastic clips (55) for clamping the chromatographic column.

5. The temperature control device for liquid chromatography tandem mass spectrometer according to claim 1, characterized in that: A refrigeration fin (31) is arranged inside the refrigeration box (3), a radiator (33) is arranged outside the refrigeration box (3), an external circulation pipe (34) is connected to the refrigeration box (3), the external circulation pipe (34) passes through and is connected to the partition (11), one end of the external circulation pipe (34) is rotatably connected to the external pipe (441), and a first fan (38) is arranged at one end of the external circulation pipe (34) away from the external pipe (441); an internal circulation pipe (35) is arranged inside the external circulation pipe (34), one end of the internal circulation pipe (35) is rotatably connected to the internal pipe (442), and the other end of the internal circulation pipe (35) passes through the external circulation side wall and is connected to the refrigeration box (3).

6. The temperature control device for liquid chromatography tandem mass spectrometer according to claim 5, characterized in that: The ends of the connection between the inner circulation pipe (35) and the inner pipe (442) are both provided with baffles (36), and a plurality of through holes (37) are provided on the baffles (36), wherein when the cold air pipe (44) rotates, the baffles (36) on one side block the through holes (37) on the baffles (36) on the other side, or the through holes (37) on the baffles (36) on both sides are connected, and the through holes (37) realize the connection or blocking of the inner circulation pipe (35) and the inner pipe (442).

7. The temperature control device for liquid chromatography tandem mass spectrometer according to claim 1, characterized in that: The driving assembly (7) comprises a driving motor (71) fixed on the partition (11); the output end of the driving motor (71) is connected to a first gear (72); the cold air pipe (44) is provided with a second gear (48) drivingly connected to the first gear (72); the sleeve (42) is provided with a limiting groove (412); the outer side wall of the cold air pipe (44) is provided with a limiting block (45) sliding along the limiting groove (412).

8. The temperature control device for liquid chromatography tandem mass spectrometer according to claim 1, characterized in that: The heating box (2) is provided with an air inlet (21), an electric heating element (22) is arranged inside the heating box (2), and a second fan (23) is arranged at the connection point of the heating box (2) with the sleeve (42).

9. The temperature control device for liquid chromatography tandem mass spectrometer according to claim 1, characterized in that: The column temperature box (1) is provided with a control panel (15), the fixed plate (43) is provided with a temperature sensor for monitoring the temperature inside the heat preservation cover (6), the control panel (15) is electrically connected to the temperature sensor, and a box door (14) is provided on one side of the operation chamber (12).

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