Beewax wax therapy product and preparation method thereof

Abstract

The invention relates to the technical field of medical health care products, and particularly discloses a beewax wax therapy product and a preparation method thereof. The beeswax wax therapy product comprises the following components in parts by weight: 60-80 parts of beeswax, 10-16 parts of a propolis extract, 10-30 parts of a traditional Chinese medicine extract, 5-10 parts of a plasticizer, 1-3 parts of an absorption enhancer and 0.8-2.2 parts of a compatilizer, the absorption enhancer is prepared by mixing mannitol, azone and protein peptide according to the weight ratio of (1-5): (1-5): (0.2-0.6); the compatilizer is formed by mixing squalene and a surfactant according to the weight ratio of (1-3): (0.2-0.8); the preparation method of the traditional Chinese medicine extract comprises the following steps: respectively weighing corresponding parts by weight of traditional Chinese medicine raw materials, mixing, and then carrying out alcohol extraction and vacuum concentration. The beeswax wax therapy product prescription provided by the invention has the effects of warming and activating meridians, dispelling wind and eliminating dampness, promoting blood circulation to arrest pain, easing pain and resisting inflammation, and the beeswax wax therapy product provided by the invention has good safety and stability.

Description

Technical Field

[0001] The present application relates to the technical field of medical and health care products, and in particular to a beeswax wax therapy product and a preparation method thereof. Background Art

[0002] Beeswax, as a natural bioactive substance, has a long history of application in traditional Chinese medicine. Traditional beeswax therapy mainly involves applying heated beeswax to the affected area, using its thermal effect and pharmacological effects to achieve therapeutic effects.

[0003] However, existing beeswax products still need to be improved in terms of formulation, preparation process and application effect. Specifically, beeswax has a single component and lacks synergy with other Chinese medicine ingredients; the preparation process is simple and it is difficult to ensure the stability and safety of the product; the application effect is limited and cannot meet the diverse clinical needs.

[0004] Therefore, developing a beeswax wax therapy product with excellent therapeutic effect and its preparation method and application has important practical significance and market value. Summary of the invention

[0005] In order to solve the above technical problems, the present application provides a beeswax wax therapy product and a preparation method thereof.

[0006] The present application provides a beeswax wax therapy product, which specifically includes the following components in parts by weight: 60-80 parts of beeswax, 10-16 parts of propolis extract, 10-30 parts of Chinese herbal medicine extract, 5-10 parts of plasticizer, 1-3 parts of absorption promoter, and 0.8-2.2 parts of compatibilizer;

[0007] The absorption enhancer is composed of a mixture of mannitol, azone and protein peptide in a weight ratio of 1-5:1-5:0.2-0.6;

[0008] The compatibilizer is composed of a mixture of squalene and a surfactant in a weight ratio of 1-3:0.2-0.8;

[0009] The preparation method of the traditional Chinese medicine extract is as follows: according to weight parts, 60-80 parts of Chuanxiong, 20-30 parts of Angelica sinensis, 20-30 parts of ginseng, 10-20 parts of Panax notoginseng, 10-20 parts of Leonurus japonicus, 10-20 parts of Lycium barbarum, 5-10 parts of Notopterygium wilfordii, 5-10 parts of Angelica dahurica, 2-4 parts of Cassia twig, and 2-4 parts of Gentiana macrophylla are respectively weighed and mixed, and then the mixture is extracted with alcohol and concentrated under reduced pressure to obtain the extract.

[0010] The beeswax wax therapy product prescription provided in the present application has the effects of warming the meridians and dredge the collaterals, dispelling wind and dampness, promoting blood circulation and relieving pain, and has been proven to have analgesic and anti-inflammatory effects through efficacy tests; in the process of formula design, the applicant fully considered the characteristics of beeswax wax therapy products as an external dosage form, especially the characteristics of promoting transdermal absorption, so that the prepared beeswax wax therapy products have the characteristics of fast absorption speed, rapid onset of effect and long-lasting effect.

[0011] In the process of preparing beeswax wax therapy products, how to enhance the warming meridians and collaterals, and expelling wind and dampness effects of beeswax products through formula design is a difficult problem. This application is based on TCM syndrome differentiation and treatment, scientific formula, and reference to the achievements of modern pharmacological research, screens out natural edible herbal medicines, formulates according to TCM theory, and extracts the essence.

[0012] In the technical scheme of the present application, beeswax is used as the main raw material, which has the effects of detoxification, tissue regeneration, diarrhea, hemostasis and pain relief, and is mainly used to treat carbuncle, back ulcer, acute heart pain, diarrhea with pus and blood, chronic diarrhea, fetal bleeding, spermatorrhea and leucorrhea, as the main drug. Propolis extract is used as an auxiliary material, which has the effects of antioxidant, antibacterial, anti-inflammatory and anti-cancer; as a ministerial drug, it assists and strengthens the efficacy of the main drug.

[0013] Among the Chinese herbal extracts, the selected Chuanxiong is pungent, warm, fragrant and dry, and can move without staying. It can disperse and go up to the top of the head; it can also enter the blood and go down to the blood sea, and has a wide range of blood circulation and blood stasis removal effects. It is suitable for various diseases of blood stasis, wind and pain relief, and has a very good effect; the selected Angelica sinensis is sweet, pungent and warm in nature, and enters the liver, heart and spleen meridians, which can nourish blood, promote blood circulation, regulate menstruation and relieve pain, moisturize dryness and lubricate the intestines; the selected ginseng is sweet and slightly bitter, warm or flat in nature, and enters the spleen, lung and heart meridians. Its main effects include greatly replenishing vital energy, restoring pulse and consolidating collapse, and replenishing spleen and benefiting The selected Panax notoginseng has multiple functions and applications, including hemostasis, blood circulation and blood stasis, swelling and pain relief; the selected Leonurus japonicus has the main functions of blood circulation and menstruation regulation, diuresis and swelling relief, heat-clearing and detoxification, etc.; the selected Lycium barbarum is sweet and flat in nature, belongs to the liver and kidney meridians, and has the functions of nourishing the liver and kidney, delaying aging, replenishing deficiency and producing essence, nourishing the liver and improving eyesight; therefore, it is an adjuvant, assisting the main drug, and can also assist the main drug in relieving certain secondary symptoms, such as reducing other side effects of damage to liver and kidney functions and reduced appetite. The selected Qiang active herb has a pungent and warm taste, enters the bladder and kidney meridians, and has the functions of dispersing superficial cold, removing rheumatism, and benefiting joints; the selected Duhuo herb has a pungent and warm taste, enters the kidney and bladder meridians, and has the functions of dispelling wind, overcoming dampness, dispersing cold, and relieving pain, and is used to treat wind-cold-damp arthritis, sore waist, cramps and pains in hands and feet, chronic bronchitis, headache, and toothache; the selected Guizhi has a pungent and sweet taste, and is warm, enters the bladder, heart, and lung meridians, and has the functions of sweating, relieving muscles, warming the meridians and dredgeing blood vessels; the selected Qinjiao has a bitter and pungent taste, and is flat, enters the liver, stomach, and gallbladder meridians, and has the functions of dispelling wind and dampness, harmonizing blood and relaxing muscles, and clearing away heat and promoting diuresis; as the guiding drug.

[0014] It should be noted that the beeswax wax therapy product of the present application is a dosage form for external use, and its specific effects may be affected by multiple factors such as Chinese medicine ingredients, application site and individual differences; at the same time, the applicant found that the ingredients of beeswax wax therapy products are complex, and chemical reactions may occur between different ingredients, affecting the stability and efficacy of the ointment; therefore, in the preparation process of beeswax wax therapy product ointment, it is necessary to fully consider the compatibility of the absorption enhancer with other ingredients to ensure the stability and safety of the ointment.

[0015] In order to solve the above problems, the applicant added absorption enhancers and compatibilizers during the preparation of beeswax wax therapy products, and made adjustments and optimizations so that the beeswax wax therapy products can be promoted to be absorbed through the skin to achieve the best therapeutic effect while ensuring the stability and safety of the ointment.

[0016] Among absorption enhancers, mannitol has good permeability and can quickly penetrate the surface of the skin, creating favorable conditions for the absorption of Chinese medicine ingredients; secondly, mannitol can change the osmotic pressure of local tissues, thereby improving blood circulation and promoting the accumulation and penetration of Chinese medicine ingredients in target areas; in addition, mannitol may also increase the hydration of the stratum corneum of the skin through its moisturizing effect, making the stratum corneum softer and easier for Chinese medicine ingredients to penetrate. Azone is a highly efficient permeant that mainly affects the stratum corneum on the surface of active organisms, allowing effective drugs to quickly enter the body through the epidermis and reach the target directly, have affinity and infiltration with cells, and reduce defense capabilities, thereby promoting the smooth entry of drugs and exerting their effects; in specific applications, azone may help the effective ingredients of Chinese medicine penetrate the skin or mucosal barriers through its permeation enhancement effect, thereby improving the bioavailability and therapeutic effect of drugs. Protein peptides have multiple active sites that can specifically bind to different ingredients in beeswax wax therapy products, have excellent permeability and biocompatibility, and form complexes that are more easily absorbed by the skin. By adjusting the microenvironment of beeswax wax therapy products, changing the solubility or dispersion and release state of Chinese medicine ingredients, promoting uniform mixing between them, reducing interactions and decomposition between Chinese medicine ingredients, and making the entire ointment system more uniform and stable, its bioavailability and absorption efficiency are improved.

[0017] At the same time, a compatibilizer is formed by mixing squalene and surfactants in a weight ratio of 1-3:0.2-0.8; squalene can improve the oxidative stress state during the preparation and extraction of beeswax wax therapy products by scavenging free radicals, provide a more suitable physiological environment for the components of beeswax wax therapy products, and protect the active ingredients in beeswax wax therapy products from oxidative damage, thereby maintaining its original efficacy; at the same time, it can reduce the harmful substances produced by oxidation during the storage and processing of beeswax wax therapy products, which can not only ensure the safety of traditional Chinese medicine, but also improve its stability and extend the shelf life of the medicine. The emulsification and dispersing effects of surfactants can be used to effectively prevent the active ingredients in beeswax wax therapy products from aggregation or precipitation during the preparation process, ensuring the uniformity and stability of the extract. The applicant studied the synergistic mechanism between surfactants and squalene, and found the best ratio and use conditions so that the two can exert the greatest stabilizing effect in the extraction process of traditional Chinese medicine. The optimized compatibilizer is used in combination with the absorption enhancer to promote the transdermal absorption of beeswax wax therapy products, thereby achieving the best therapeutic effect and greatly improving the stability and safety of the products.

[0018] Preferably, the beeswax wax therapy product specifically comprises the following components in parts by weight: 65-75 parts of beeswax, 12-14 parts of propolis extract, 15-25 parts of traditional Chinese medicine extract, 6-9 parts of plasticizer, 1.5-2.5 parts of absorption enhancer, and 1.2-1.8 parts of compatibilizer.

[0019] Preferably, the protein peptide is selected from one or more of soybean protein peptide, egg white protein peptide and silk protein peptide.

[0020] Preferably, the absorption enhancer is composed of a mixture of mannitol, azone and egg white protein peptide in a weight ratio of 2-4:2-4:0.3-0.5.

[0021] Preferably, the compatibilizer is composed of a mixture of squalene and a surfactant in a weight ratio of 1.5-2.5:0.3-0.7.

[0022] Preferably, in the compatibilizer, the surfactant is one or more of cocamidopropyl betaine, lauroamidopropyl betaine, cocamidopropyl hydroxysulfobetaine, lauroamidopropyl amine oxide, and sodium laurylamphoacetate.

[0023] Preferably, the compatibilizer is composed of a mixture of squalene and a surfactant in a weight ratio of 1.5-2.5:0.3-0.7.

[0024] Preferably, the plasticizer is selected from one or more of glycerol, hyaluronic acid, collagen and gelatin.

[0025] Preferably, the preparation method of the Chinese medicine extract is: weigh each raw material according to weight, place it in 1000 weight parts of 40-60wt% ethanol aqueous solution, soak for 4-6 hours, heat and extract at 60-80°C for 4-6 hours, repeat the extraction twice, combine the extracts and concentrate under reduced pressure to a clear paste with a relative density of 1.1-1.3.

[0026] In a second aspect, the present application provides a method for preparing the above-mentioned beeswax wax therapy product, which specifically comprises the following steps in sequence:

[0027] Mix beeswax, propolis extract and Chinese herbal medicine extract, and heat until completely melted;

[0028] Add plasticizer, absorption promoter and compatibilizer, stir evenly; cool to room temperature to obtain the beeswax wax therapy product.

[0029] In summary, the technical solution of this application has the following effects:

[0030] The beeswax wax therapy product prescription provided in the present application has the effects of warming the meridians and dredge the collaterals, dispelling wind and dampness, promoting blood circulation and relieving pain, and has the effects of analgesia and anti-inflammatory.

[0031] This application uses formula design, based on Chinese medicine syndrome differentiation and treatment, scientific formula formulation, and reference to the achievements of modern pharmacological research, so that the prepared beeswax wax therapy products have the characteristics of fast absorption, rapid onset of effect, and long-lasting effect. DETAILED DESCRIPTION

[0032] The present application is further described in detail below in conjunction with examples, comparative examples and performance testing experiments. These examples should not be construed as limiting the scope of protection claimed in the present application.

[0033] Beeswax was purchased from Cangzhou Xintai Wax and Glue Co., Ltd.; propolis extract was purchased from Xi'an Zhanxun Biotechnology Co., Ltd.; soybean protein peptide, egg white protein peptide, and silk protein peptide were purchased from Xinyang Mufan Biotechnology Co., Ltd.; the remaining raw materials can be obtained commercially.

[0034] Example

[0035] Examples 1-5

[0036] Examples 1-5 respectively provide a beeswax wax therapy product and a preparation method thereof.

[0037] The difference between the above embodiments is that the amounts of the components in the beeswax wax treatment are different, as shown in Table 1.

[0038] Preparation of Chinese medicine extract: Weigh 70g of Chuanxiong, 25g of Angelica sinensis, 25g of ginseng, 15g of Panax notoginseng, 15g of Leonurus japonicus, 15g of Lycium barbarum, 8g of Notopterygium wilfordii, 8g of Angelica pubescens, 3g of cinnamon twig, and 3g of Gentiana macrophylla respectively, mix, place in 1000g of 50wt% ethanol aqueous solution, soak for 5h, heat and extract at 70℃ for 5h, repeat the extraction twice, combine the extracts and concentrate under reduced pressure to a clear paste with a relative density of 1.15 (60℃).

[0039] Mix beeswax, propolis extract and traditional Chinese medicine extract, heat to 120°C to completely melt, and stir for 60 minutes; add plasticizer glycerin, absorption promoter (the absorption promoter is composed of a mixture of mannitol, azone, and egg white protein peptide in a weight ratio of 3:3:0.4), and 3g of compatibilizer (composed of a mixture of squalene and cocamidopropyl hydroxysulfobetaine in a weight ratio of 2:0.5), stir at a speed of 80 rpm, and stir evenly; cool to 25°C to obtain a beeswax wax therapy product.

[0040] Table 1 The amount of each component in the beeswax wax treatment system in Examples 1-5 and Comparative Examples 1-3

[0041]

[0042] Embodiment 6-9

[0043] Examples 6-9 respectively provide a beeswax wax therapy product and a preparation method thereof.

[0044] The difference between the above embodiment and embodiment 3 is as follows.

[0045] In Example 6: the absorption enhancer is composed of a mixture of mannitol, azone and egg white protein peptide in a weight ratio of 1:5:0.6.

[0046] In Example 7: the absorption enhancer is composed of a mixture of mannitol, azone and egg white protein peptide in a weight ratio of 5:1:0.2.

[0047] In Example 8: the absorption enhancer is composed of a mixture of mannitol, azone and soybean protein peptide in a weight ratio of 3:3:0.4.

[0048] In Example 9: the absorption enhancer is composed of a mixture of mannitol, azone and silk protein peptide in a weight ratio of 3:3:0.4.

[0049] In Example 10: the absorption enhancer is composed of a mixture of mannitol, azone and egg white protein peptide in a weight ratio of 2:4:0.3.

[0050] In Example 11: the absorption enhancer is composed of a mixture of mannitol, azone and silk protein peptide in a weight ratio of 4:2:0.5.

[0051] The remaining parameters of the above embodiment are the same as those of embodiment 3.

[0052] Examples 12-19

[0053] Examples 12-19 respectively provide a beeswax wax therapy product and a preparation method thereof.

[0054] The difference between the above embodiment and embodiment 3 is: the type of compatibilizer, which is specifically shown below.

[0055] In Example 12: the compatibilizer is composed of a mixture of squalene and lauryl amide propyl amine oxide in a weight ratio of 2:0.5.

[0056] In Example 13, the compatibilizer is composed of a mixture of squalene and sodium lauryl amphoacetate in a weight ratio of 1:0.8. In Example 14, the compatibilizer is composed of a mixture of squalene and cocamidopropyl hydroxysulfobetaine in a weight ratio of 3:0.2.

[0057] In Example 15: the compatibilizer is composed of a mixture of squalene and cocamidopropyl hydroxysulfobetaine in a weight ratio of 1.5:0.6.

[0058] In Example 16: the compatibilizer is composed of a mixture of squalene and cocamidopropyl hydroxysulfobetaine in a weight ratio of 2.5:0.4.

[0059] The remaining parameters of the above embodiment are the same as those of embodiment 3.

[0060] Comparative Example

[0061] Comparative Examples 1-3

[0062] Comparative Examples 1-3 respectively provide a beeswax wax therapy product and a preparation method thereof.

[0063] The difference between the comparative example and Example 3 is that the amounts of the components in the beeswax wax preparation are different, as shown in Table 1.

[0064] The remaining parameters of the comparative example and embodiment 3 are the same.

[0065] Comparative Examples 4-7

[0066] Comparative Examples 4-7 respectively provide a beeswax wax therapy product and a preparation method thereof.

[0067] The difference between the above comparative example and Example 3 is as follows.

[0068] In Comparative Example 4: the absorption enhancer is azone.

[0069] In Comparative Example 5: the absorption enhancer is composed of a mixture of mannitol, azone and egg white protein peptide in a weight ratio of 6:0.8:0.1.

[0070] In Comparative Example 6: no compatibilizer was added.

[0071] In Comparative Example 7: the compatibilizer is squalene.

[0072] The remaining parameters of the comparative example and embodiment 3 are the same.

[0073] Performance testing

[0074] Healthy SPF Kunming mice weighing (20±2) g were selected and placed in the laboratory, half male and half female, and the animals were raised in a standard environment and fed with standard pellet feed. They were randomly divided into groups, with 8 mice in each group.

[0075] (1) Safety test: The hair on the back of the mice was trimmed, and the intact skin was selected for local skin toxicity and irritation experiments. The beeswax wax therapy product ointment obtained in each case was applied to the hair-cut area, and the occurrence of erythema and edema at the application site was observed and recorded. The observation period was 15 days; the experimental results showed that no skin erythema or edema occurred in each group, proving that the beeswax wax therapy product ointment prepared in this application had good safety.

[0076] (2) Cytotoxicity test: Freshly prepared beeswax ointment, beeswax ointment sealed and stored at room temperature for 6 months, and beeswax ointment sealed and stored at room temperature for 12 months were used as test objects, and the cytotoxicity test of beeswax ointment was tested by MTT method. The specific test method is as follows:

[0077] S1: Cell culture: 1×10 5 Fibroblasts were inoculated at a density of 10 cells / mL and cultured at 5% CO2 and 37°C for 24 h.

[0078] S2: drug administration: using serum-free fibroblast growth culture medium, prepare a culture medium containing 4 wt% beeswax wax therapy product ointment as the experimental group culture medium, replace the culture medium in step S1 with the prepared experimental group culture medium, and continue culturing for 24 hours;

[0079] At the same time, a culture medium containing 4 wt % DMSO was prepared as a positive control group; and a culture medium without any treatment was used as a blank group.

[0080] S3: Detection: After the culture is completed, the supernatant is discarded, and 200 μL of 0.5 mg / mL MTT working solution is added. After incubation at 37°C in the dark for 4 hours, the supernatant is discarded, 150 μL of dimethyl sulfoxide is added to each well, and the OD490 value is read using a microplate reader.

[0081] The cell OD value of the blank group was taken as 100% cell viability, and the cell viability values ​​of the experimental group and the positive control group were calculated. Three groups were measured in parallel, and the average value of cell viability was calculated to evaluate cytotoxicity.

[0082] Test results: as shown in Table 2.

[0083] Table 2 Cytotoxicity test results of beeswax wax products

[0084]

[0085]

[0086] Combined with the cell viability test results in Table 2, it can be seen that the beeswax wax therapy products prepared in the present application are added to the culture medium for culturing fibroblasts, and the cell viability after 6 months of storage is higher than 90.48%; the cell viability after 12 months of storage is higher than 85.85%, indicating that the beeswax wax therapy products of the present application are non-cytotoxic and highly safe.

[0087] (3) Hot plate analgesic test: Take experimental mice and measure the pain threshold according to the following method before administration: Place the experimental mice on an intelligent hot plate instrument preheated to 55±0.5℃, start timing from the time when the mouse's hind foot touches the hot plate, and use the mouse licking its hind foot as the pain response index. Measure 3 times and take the average value. Then, the drugs are divided into the following groups: the blank group is not given any drug; the example group and the comparative group are given 0.4g of the ointment respectively, and the right hind limb of the rat is applied with appropriate massage to promote drug absorption, and fixed with medical tape. The drug is administered once a day, 6 hours each time, for 3 consecutive days. The pain threshold is measured 15min, 30min, and 60min after the last administration.

[0088] Test results: as shown in Table 3.

[0089] (4) Experiment on the anti-inflammatory effect of xylene on the swelling of the auricle of experimental mice: Experimental mice were taken, and 30ul / mouse xylene was applied to the front and back sides of the right ear of each experimental mouse to cause swelling of the right auricle, and the left auricle was not treated. Then the drugs were divided into the following groups: the blank group was not given any drug, and the example group and the comparative example group were given 0.4g of the ointment respectively. After applying it on both sides of the right ear of the rat, appropriate massage was performed to promote drug absorption, and the ointment was fixed with medical tape. After 1 hour, the experimental mice were killed by cervical dislocation, and round ear pieces were punched in the same part of the ears on both sides with a 6mm diameter puncher. The mass was weighed with a balance, and the swelling degree and swelling rate were calculated.

[0090] Swelling degree = right ear piece weight - left ear piece weight; Swelling rate = (right ear piece weight - left ear piece weight) / left ear piece weight × 100%. Test results: as shown in Table 3.

[0091] Table 3 Performance test results of beeswax wax products in Examples and Comparative Examples

[0092]

[0093] Combined with the test results of Table 3, no absorption enhancer was added in Comparative Example 1, the dosage of each raw material in Comparative Examples 2-3 was not matched, the absorption enhancer in Comparative Example 4 was azone, and the absorption enhancer in Comparative Example 5 was composed of a mixture of mannitol, azone, and egg white protein peptide in a weight ratio of 6:0.8:0.1. In the preparation method of the Chinese medicine extract in Comparative Example 6, no compatibilizer was added, and in the preparation method of the Chinese medicine extract in Comparative Example 7, the compatibilizer was squalene. The efficacy of the beeswax wax treatment products prepared in the above comparative examples is poor. In contrast, the beeswax wax treatment product prescription obtained by the technical solution of the present application has the effects of warming the meridians and dredge the collaterals, dispelling wind and dampness, promoting blood circulation and relieving pain, and has the effect of analgesia and anti-inflammatory.

[0094] Although the present invention has been described in detail above with general descriptions and specific embodiments, it is obvious to those skilled in the art that some modifications or improvements may be made thereto based on the present invention. Therefore, these modifications or improvements made without departing from the spirit of the present invention all fall within the scope of protection claimed by the present invention.

Claims

1. A beeswax wax therapy product, characterized in that: Specifically, it includes the following components in parts by weight: 60-80 parts of beeswax, 10-16 parts of propolis extract, 10-30 parts of Chinese herbal medicine extract, 5-10 parts of plasticizer, 1-3 parts of absorption promoter, and 0.8-2.2 parts of compatibilizer; The absorption enhancer is composed of a mixture of mannitol, azone and protein peptide in a weight ratio of 1-5:1-5:0.2-0.6; The compatibilizer is composed of a mixture of squalene and a surfactant in a weight ratio of 1-3:0.2-0.8; The preparation method of the traditional Chinese medicine extract is as follows: according to weight parts, 60-80 parts of Chuanxiong, 20-30 parts of Angelica sinensis, 20-30 parts of ginseng, 10-20 parts of Panax notoginseng, 10-20 parts of Leonurus japonicus, 10-20 parts of Lycium barbarum, 5-10 parts of Notopterygium wilfordii, 5-10 parts of Angelica dahurica, 2-4 parts of Cassia twig, and 2-4 parts of Gentiana macrophylla are respectively weighed and mixed, and then the mixture is extracted with alcohol and concentrated under reduced pressure to obtain the extract.

2. The beeswax wax therapy product according to claim 1, characterized in that: Specifically, the invention comprises the following components in parts by weight: 65-75 parts of beeswax, 12-14 parts of propolis extract, 15-25 parts of Chinese herbal medicine extract, 6-9 parts of plasticizer, 1.5-2.5 parts of absorption promoter and 1.2-1.8 parts of compatibilizer.

3. The beeswax wax therapy product according to claim 1, characterized in that: The protein peptide is selected from one or more of soybean protein peptide, egg white protein peptide and silk protein peptide.

4. The beeswax wax therapy product according to claim 1, characterized in that: The absorption enhancer is composed of a mixture of mannitol, azone and egg white protein peptide in a weight ratio of 2-4:2-4:0.3-0.

5.

5. The beeswax wax therapy product according to claim 1, characterized in that: The compatibilizer is composed of squalene and surfactant in a weight ratio of 1.5-2.5:0.3-0.

7.

6. The beeswax wax therapy product according to claim 1, characterized in that: In the compatibilizer, the surfactant is one or more of cocamidopropyl betaine, lauroamidopropyl betaine, cocamidopropyl hydroxysulfobetaine, lauroamidopropyl amine oxide, and sodium laurylamphoacetate.

7. The beeswax wax therapy product according to claim 1, characterized in that: The compatibilizer is composed of squalene and surfactant in a weight ratio of 1.5-2.5:0.3-0.

7.

8. The beeswax wax therapy product according to claim 1, characterized in that: The plasticizer is selected from one or more of glycerol, hyaluronic acid, collagen and gelatin.

9. The beeswax wax therapy product according to claim 1, characterized in that: The preparation method of the Chinese herbal medicine extract is as follows: weighing each raw material according to weight, placing it in 1000 weight parts of 40-60wt% ethanol aqueous solution, soaking for 4-6 hours, heating and extracting at 60-80°C for 4-6 hours, repeating the extraction twice, combining the extracts and concentrating them under reduced pressure to a clear paste with a relative density of 1.1-1.

3.

10. The method for preparing the beeswax wax therapy product according to any one of claims 1 to 9, characterized in that: Specifically, the following steps are performed in sequence: Mix beeswax, propolis extract and Chinese herbal medicine extract, and heat until completely melted; Add plasticizer, absorption promoter and compatibilizer, stir evenly; cool to room temperature to obtain the beeswax wax therapy product.

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