Bromochlorohydantoin tablet and preparation method thereof

Abstract

The invention relates to the technical field of disinfectants, and discloses a bromochlorohydantoin tablet which is prepared by mixing the following raw materials in parts by weight: 8 parts of bromochlorohydantoin, 78-82.2 parts of anhydrous sodium sulfate, 2.4-3.2 parts of microcrystalline cellulose, 6.4-9.6 parts of lactose and 1.0-1.2 parts of croscarmellose sodium. According to the invention, the defect that the existing dosage form of bromochlorohydantoin cannot realize disinfection and improvement of a pond substrate is overcome, and effective components are continuously released while the bromochlorohydantoin sinks to the water bottom, so that better disinfection and improvement effects on the bottom of the pond can be realized; the powder is directly tableted without wetting and drying, so that the stability of the medicine in the tablet manufacturing process is more facilitated; finished products are convenient to transport; the preparation is simple, the quality is stable, the use is convenient, the product dissolution speed is high, the concentration of effective bromine and effective chlorine in water can be instantly increased, and the sterilization and disinfection effects of bromochlorohydantoin are enhanced; therefore, the stability of bromochlorohydantoin and the function of purifying water are improved.

Description

Technical Field

[0001] The invention relates to the technical field of disinfectants and bactericides, in particular to bromochlorohydrin tablets and a preparation method thereof. Background Art

[0002] Bromine chlorine hydrazine is a new type of bactericidal and disinfecting water treatment agent. It is widely used in agricultural irrigation, industrial water treatment systems, indoor and outdoor swimming (bath) pools, sanitary systems and disinfection of aquaculture water environments.

[0003] The existing dosage form of bromochlorohydrin needs to be diluted with water and then sprayed for water disinfection. However, with this disinfection method, it is difficult for the disinfectant to reach the bottom of the water, and it is impossible to disinfect and improve the bottom of the pond. After the solid disinfectant is put into the pond, it continuously releases the effective ingredients while sinking to the bottom of the water, thereby having a better disinfection and improvement effect on the bottom of the pond. Therefore, we make bromochlorohydrin into tablets for application to solve the problem that the current commercially available products have unsatisfactory disinfection effect on the bottom of the pond. Summary of the invention

[0004] 1. Technical issues to be resolved In view of the deficiencies of the prior art, the present invention provides bromochlorohydantoin tablets and a preparation method thereof to solve the problems raised in the above-mentioned background technology. After bromochlorohydantoin is made into tablets, the tablets have the advantages of stable quality and easy transportation.

[0005] (II) Technical solution To achieve the above object, the present invention provides the following technical solution: bromochlorohydantoin tablets are prepared by mixing the following raw materials in parts by weight: 8 parts of bromochlorohydantoin, 78-82.2 parts of anhydrous sodium sulfate, 2.4-3.2 parts of microcrystalline cellulose, 6.4-9.6 parts of lactose, and 1.0-1.2 parts of cross-linked sodium carboxymethyl cellulose.

[0006] Preferably, the bromochlorohydrin tablets are prepared by mixing the following raw materials in parts by weight: 8 parts of bromochlorohydrin, 78.2 parts of anhydrous sodium sulfate, 3.2 parts of microcrystalline cellulose, 9.6 parts of lactose, and 1 part of cross-linked sodium carboxymethyl cellulose.

[0007] Preferably, the bromochlorohydrin tablets are prepared by mixing the following raw materials in parts by weight: 8 parts of bromochlorohydrin, 78 parts of anhydrous sodium sulfate, 3.2 parts of microcrystalline cellulose, 9.6 parts of lactose, and 1.2 parts of cross-linked sodium carboxymethyl cellulose.

[0008] Preferably, the bromochlorohydrin tablets are prepared by mixing the following raw materials in parts by weight: 8 parts of bromochlorohydrin, 82.2 parts of anhydrous sodium sulfate, 2.4 parts of microcrystalline cellulose, 6.4 parts of lactose, and 1 part of cross-linked sodium carboxymethyl cellulose.

[0009] Preferably, the bromochlorohydrin tablets are prepared by mixing the following raw materials in parts by weight: 8 parts of bromochlorohydrin, 79.6 parts of anhydrous sodium sulfate, 3.2 parts of microcrystalline cellulose, 8 parts of lactose, and 1.2 parts of cross-linked sodium carboxymethyl cellulose.

[0010] The present invention also provides a method for preparing bromochlorohydantoin tablets, which comprises the following steps: S1: Grinding and sieving: Grind bromochlorohydantoin, anhydrous sodium sulfate, microcrystalline cellulose, lactose, and cross-linked sodium carboxymethyl cellulose through a 100-mesh sieve respectively; S2: Mixing: weigh the above raw materials and auxiliary materials in proportion, first put anhydrous sodium sulfate into the mixer, then pour in microcrystalline cellulose, lactose and cross-linked sodium carboxymethyl cellulose, and finally add bromochlorohydrin, and continue mixing for 20 minutes to obtain powder; S3: Tablet preparation: The powder obtained in S2 is tableted using a dry tablet press. The filling depth of the tablet press is set to 9.6 mm, the turntable speed is set to 20 r / min, and the pressure is set to 20 KN. The powder is pressed into tablets to obtain the product.

[0011] Compared with the prior art, the present invention provides bromochlorohydantoin tablets and a preparation method thereof, which have the following beneficial effects: 1. The present invention solves the problem that the existing dosage forms of bromochlorohydrin cannot achieve the disinfection and improvement of pond bottom. The present invention continuously releases the active ingredients while sinking to the bottom of the water, thereby having a better disinfection and improvement effect on the bottom of the pond; the powder is directly pressed into tablets without wetting and drying, which is more conducive to the stability of the drug in the tablet manufacturing process; the finished product is easy to transport; and the present invention is simple to prepare, has stable quality, and is easy to use, and the present invention meets the requirements for tablets in the first part of the 2020 edition of the Chinese Veterinary Pharmacopoeia; 2. The present invention is simple to prepare, has stable quality, is easy to use, and has a fast dissolution rate. At the same time, the concentrations of effective bromine and effective chlorine in water are instantly increased, the bactericidal and disinfecting effects of bromochlorohydrin are enhanced, and the stability of bromochlorohydrin and the function of purifying water quality are improved. DETAILED DESCRIPTION

[0012] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0013] Embodiment 1 S1: Grinding and sieving: Grind bromochlorohydantoin, anhydrous sodium sulfate, microcrystalline cellulose, lactose, and cross-linked sodium carboxymethyl cellulose through a 100-mesh sieve respectively; S2: Mixing: First, 78.2 parts of anhydrous sodium sulfate are put into a mixer, then 3.2 parts of microcrystalline cellulose, 9.6 parts of lactose and 1 part of cross-linked sodium carboxymethyl cellulose are added, and finally 8 parts of bromochlorohydantoin raw material are added, and the mixture is placed in a mixer and mixed continuously for 20 minutes to obtain a powder; S3: Tablet preparation: The powder obtained in S2 is tableted using a dry tablet press. The filling depth of the tablet press is set to 9.6 mm, the turntable speed is set to 20 r / min, and the pressure is set to 20 KN. The powder is pressed into tablets to obtain the product.

[0014] Embodiment 2 S1: Grinding and sieving: Bromochlorohydantoin, anhydrous sodium sulfate, microcrystalline cellulose, lactose, and cross-linked sodium carboxymethyl cellulose are pulverized and sieved through a 100-mesh sieve respectively; S2: Mixing: First, 78 parts of anhydrous sodium sulfate are put into a mixer, then 3.2 parts of microcrystalline cellulose, 9.6 parts of lactose and 1.2 parts of cross-linked carboxymethyl cellulose sodium are added, and finally 8 parts of bromochlorohydantoin raw material are added, and the mixture is placed in a mixer and mixed continuously for 20 minutes to obtain a powder; S3: Tablet preparation: The powder obtained in S2 is tableted using a dry tablet press. The filling depth of the tablet press is set to 9.6 mm, the turntable speed is set to 20 r / min, and the pressure is set to 20 KN. The powder is pressed into tablets to obtain the product.

[0015] Embodiment 3 S1: Grinding and sieving: Bromochlorohydantoin, anhydrous sodium sulfate, microcrystalline cellulose, lactose, and cross-linked sodium carboxymethyl cellulose are pulverized and sieved through a 100-mesh sieve respectively; S2: Mixing: First, put 82.2 parts of anhydrous sodium sulfate into a mixer, then pour in 2.4 parts of microcrystalline cellulose, 6.4 parts of lactose and 1 part of cross-linked sodium carboxymethyl cellulose, and finally add 8 parts of bromochlorohydantoin raw material, place in a mixer, and continuously mix for 20 minutes to obtain a powder; S3: Tablet preparation: The powder obtained in S2 is tableted using a dry tablet press. The filling depth of the tablet press is set to 9.6 mm, the turntable speed is set to 20 r / min, and the pressure is set to 20 KN. The powder is pressed into tablets to obtain the product.

[0016] Embodiment 4 S1: Grinding and sieving: Bromochlorohydantoin, anhydrous sodium sulfate, microcrystalline cellulose, lactose, and cross-linked sodium carboxymethyl cellulose are pulverized and sieved through a 100-mesh sieve respectively; S2: Mixing: First, 79.6 parts of anhydrous sodium sulfate were put into a mixer, then 3.2 parts of microcrystalline cellulose, 8.0 parts of lactose and 1.2 parts of cross-linked carboxymethyl cellulose sodium were added, and finally 8 parts of bromochlorohydantoin raw material were added, and the mixture was placed in a mixer and mixed continuously for 20 minutes to obtain a powder; S3: Tablet preparation: The powder obtained in S2 is tableted using a dry tablet press. The filling depth of the tablet press is set to 9.6 mm, the turntable speed is set to 20 r / min, and the pressure is set to 20 KN. The powder is pressed into tablets to obtain the product.

[0017] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. Bromochlorohydrin tablets, characterized in that, The invention is prepared by mixing the following raw materials in parts by weight: 8 parts of bromochlorohydantoin, 78-82.2 parts of anhydrous sodium sulfate, 2.4-3.2 parts of microcrystalline cellulose, 6.4-9.6 parts of lactose and 1.0-1.2 parts of cross-linked sodium carboxymethyl cellulose.

2. The bromochlorohydantoin tablet according to claim 1, characterized in that The preparation method is prepared by mixing the following raw materials in parts by weight: 8 parts of bromochlorohydantoin, 78.2 parts of anhydrous sodium sulfate, 3.2 parts of microcrystalline cellulose, 9.6 parts of lactose and 1 part of cross-linked sodium carboxymethyl cellulose.

3. Bromochlorohydrin tablets according to claim 1, characterized in that, The preparation method is prepared by mixing the following raw materials in parts by weight: 8 parts of bromochlorohydantoin, 78 parts of anhydrous sodium sulfate, 3.2 parts of microcrystalline cellulose, 9.6 parts of lactose and 1.2 parts of cross-linked sodium carboxymethyl cellulose.

4. The bromochlorohydantoin tablet according to claim 1, characterized in that The preparation method is prepared by mixing the following raw materials in parts by weight: 8 parts of bromochlorohydantoin, 82.2 parts of anhydrous sodium sulfate, 2.4 parts of microcrystalline cellulose, 6.4 parts of lactose and 1 part of cross-linked sodium carboxymethyl cellulose.

5. The bromochlorohydantoin tablet according to claim 1, characterized in that: The preparation method is prepared by mixing the following raw materials in parts by weight: 8 parts of bromochlorohydantoin, 79.6 parts of anhydrous sodium sulfate, 3.2 parts of microcrystalline cellulose, 8 parts of lactose, and 1.2 parts of cross-linked sodium carboxymethyl cellulose.

6. The bromochlorohydantoin tablet according to claim 1-5, characterized in that: The preparation method thereof comprises the following steps: S1: Grinding and sieving: Grind bromochlorohydantoin, anhydrous sodium sulfate, microcrystalline cellulose, lactose, and cross-linked sodium carboxymethyl cellulose through a 100-mesh sieve respectively; S2: Mixing: weigh the above raw materials and auxiliary materials in proportion, first put anhydrous sodium sulfate into the mixer, then pour in microcrystalline cellulose, lactose and cross-linked sodium carboxymethyl cellulose, and finally add bromochlorohydrin, and continue mixing for 20 minutes to obtain powder; S3: Tablet preparation: The powder obtained in S2 is tableted using a dry tablet press. The filling depth of the tablet press is set to 9.6 mm, the turntable speed is set to 20 r / min, and the pressure is set to 20 KN. The powder is pressed into tablets to obtain the product.