Dressing paste for preventing wound infection

Abstract

The invention relates to a dressing patch for preventing wound infection, which comprises a base layer, a colloid dressing layer and release paper, the colloid dressing layer is internally provided with a colloid dressing and an antibacterial layer, and the antibacterial layer is prepared from the following raw materials in percentage by weight: 20-80% of clinopodium chinense, 20-80% of folium artemisiae argyi, 20-80% of folium artemisiae argyi, 20-80% of folium artemisiae argyi and 20-80% of folium artemisiae argyi. 5%-20% of chitosan; 2%-10% of bletilla striata; 6%-10% of alum; 3%-10% of sanguisorba officinalis; 20%-50% of borneol; the produced dressing patch is good in water absorption, so that when a patient uses the dressing patch, liquid exuding from a wound can be absorbed, healing of the wound is promoted, meanwhile, calamint and chitosan added in the dressing patch have a good sterilization function and can prevent wound infection, and meanwhile, due to the arrangement of borneol, the pain feeling of the patient can be reduced.

Description

Technical Field

[0001] The invention relates to the technical field of dressing patches, in particular to a dressing patch for preventing wound infection. Background Art

[0002] Dressings are medical materials used to temporarily cover wounds and wound surfaces. Surgical dressings are wound dressings, which are medical materials used to cover sores, wounds or other injuries. With the in-depth study of the pathophysiology of wound healing, people have a deeper understanding of the wound healing process, which has led to the continuous improvement and development of medical wound dressings.

[0003] After searching, the Chinese patent with announcement number: CN204072492U discloses a medical transparent dressing patch, which includes: a disinfectant layer, the bottom surface of which is coated with a medical adhesive; a transparent dressing layer, the disinfectant layer is bonded to the central part of the surface of the transparent dressing layer, and the bottom surface of the transparent dressing layer is coated with a medical adhesive; a drying layer, which is arranged at the central part of the bottom surface of the transparent dressing layer and is used to absorb moisture; a hemostatic layer, which covers the drying layer and is bonded to the bottom surface of the drying layer; and a release paper layer, which covers the hemostatic layer and the drying layer and is bonded to the bottom surface of the transparent dressing layer. The medical transparent dressing patch of the utility model can ensure the dryness of the wearing part and prevent the infection of the skin wound.

[0004] After exploration and analysis, the medical dressing produced by this patent has the following disadvantages when actually used: Although a small amount of nanosilver is added to the dressing in this patent for disinfection, for wounds of larger areas, it is necessary to promote wound healing. Obviously, this patent cannot achieve the function of quickly promoting wound healing. Summary of the invention

[0005] Although a small amount of nanosilver is added to the dressing in the existing patent for disinfection, for wounds of larger areas, it is necessary to promote wound healing. Obviously, there is a technical problem in the patent that it cannot achieve the function of quickly promoting wound healing. The present invention provides a dressing for preventing wound infection.

[0006] The technical solution adopted by the present invention is: a dressing patch for preventing wound infection, comprising a base layer, a colloidal dressing layer and a release paper, wherein the colloidal dressing layer is provided with a colloidal dressing and an antibacterial layer, wherein the antibacterial layer is composed of the following raw materials according to weight percentage: Pinwheel vegetable: 20%-80%; Chitosan: 5%-20%; Bletilla striata: 2%-10%; Alum: 6%-10%; Sanguisorba officinalis: 3%-10%; Borneol: 20%-50%; Wherein, the colloid dressing is composed of hydrogel; The hydrogel is composed of the following raw materials in weight percentage: 30% water for injection, 3% sodium chloride, 3% potassium chloride, 5% liquid silicon dioxide, 10% glycerol, 6% hydroxyethyl cellulose, 8% hydroxyethylene copolymer, 20% sodium carboxymethyl cellulose, and 15% sodium hydroxide.

[0007] Furthermore, the antibacterial layer is composed of the following raw materials in terms of weight percentage: Pinwheel vegetable: 30%; Chitosan: 10%; Bletilla striata: 5%; Alum: 8%; Sanguisorba officinalis: 8%; Borneol: 39%.

[0008] Furthermore, the antibacterial layer is composed of the following raw materials in terms of weight percentage: Pinwheel vegetable: 40%; Chitosan: 8%; Bletilla striata: 3%; Alum: 6%; Sanguisorba officinalis: 6%; Borneol: 37%.

[0009] Furthermore, the antibacterial layer is composed of the following raw materials in terms of weight percentage: Pinwheel vegetable: 50%; Chitosan: 6%; Bletilla striata: 1%; Alum: 4%; Sanguisorba officinalis: 4%; Borneol: 35%.

[0010] Furthermore, the antibacterial layer is composed of the following raw materials in terms of weight percentage: Pinwheel vegetable: 60%; Chitosan: 1%; Bletilla striata: 1%; Alum: 2%; Sanguisorba officinalis: 2%; Borneol: 34%.

[0011] Furthermore, the colloidal dressing layer is prepared according to the following steps: Step S1: Weighing the raw materials for the antibacterial layer: weighing corresponding weight portions of Herba Cynanchii, chitosan, Bletilla striata, Alum, Radix Sanguisorbae, and Borneol; Step S2: crushing the raw materials: pouring the raw materials weighed in step S1 into a crusher for crushing at a crushing speed of 500 rpm for 3 min to obtain a mixed powder A; Step S3: Weighing the raw materials of the colloidal dressing: Weigh corresponding weight portions of water for injection, sodium chloride, potassium chloride, liquid silicon dioxide, glycerol, hydroxyethyl cellulose, hydroxyethylene copolymer, sodium carboxymethyl cellulose, and sodium hydroxide for later use; Step S4: adding liquid silicon dioxide into the melt tank, stirring at a stirring speed of 50 r / min for 15 min; Step S5: pouring hydroxyethyl cellulose, hydroxyethylene copolymer and sodium carboxymethyl cellulose into the melt tank in step S4 and mixing for 10 minutes to obtain a liquid colloidal mixture B; Step S6: pouring water for injection, sodium chloride, potassium chloride, liquid silicon dioxide, glycerin and mixture B into a blender for stirring and mixing, and then adding sodium hydroxide to adjust the pH value to 7.0-8.0, and then obtaining mixture C; Step S7: pouring the mixture C in step S6 and the mixed powder A in step S1 into a kneader, setting the temperature to 100-120°C, stirring at 100 r / min for 15 min, and then placing the product of the kneader in a flat vulcanizer for 30 min, setting the temperature to 100°C, and then obtaining a colloidal dressing layer; Step S8: Apply the colloid dressing layer obtained in step S7 on the base layer, control the thickness to be 3 mm, and then cover it with release paper.

[0012] The beneficial effects of the present invention are as follows: compared with the prior art, the dressing produced in the present invention has a better water absorption rate, so it can absorb the liquid exuded from the wound when used by the patient; at the same time, the physalis and chitosan added in the present invention have a good bactericidal function, can prevent wound infection, and promote wound healing; at the same time, the setting of borneol can reduce the patient's pain. DETAILED DESCRIPTION

[0013] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0014] In order to solve the problems existing in the background technology, this application proposes the following technical solutions: A dressing patch for preventing wound infection comprises a base layer, a colloid dressing layer and a release paper, wherein the colloid dressing layer is provided with a colloid dressing and an antibacterial layer. The antibacterial layer is composed of the following raw materials according to weight percentage: 20%-80% of ophiopogon erythrorhizon; 5%-20% of chitosan; 2%-10% of bletilla striata; 6%-10% of alum; 3%-10% of sanguisorba officinalis; 20%-50% of borneol; Wherein, the colloid dressing is composed of hydrogel; The hydrogel is composed of the following raw materials in weight percentage: 30% water for injection, 3% sodium chloride, 3% potassium chloride, 5% liquid silicon dioxide, 10% glycerol, 6% hydroxyethyl cellulose, 8% hydroxyethylene copolymer, 20% sodium carboxymethyl cellulose, and 15% sodium hydroxide.

[0015] Embodiment 1 This embodiment makes an improvement on the antibacterial layer, and the antibacterial layer is composed of the following raw materials in weight percentage: Herba Cynanchii: 30%; Chitosan: 10%; Bletilla striata: 5%; Alum: 8%; Sanguisorba officinalis: 8%; Borneol: 39%.

[0016] Embodiment 2 This embodiment makes an improvement on the antibacterial layer, which is composed of the following raw materials in weight percentage: Herba Cynanchii: 40%; Chitosan: 8%; Bletilla striata: 3%; Alum: 6%; Sanguisorba officinalis: 6%; and Borneol: 37%.

[0017] Embodiment 3 This embodiment makes an improvement on the antibacterial layer, and the antibacterial layer is composed of the following raw materials in weight percentage: Herba Cyperi: 50%; Chitosan: 6%; Bletilla striata: 1%; Alum: 4%; Sanguisorba officinalis: 4%; Borneol: 35%.

[0018] Embodiment 4 This embodiment makes an improvement on the antibacterial layer, and the antibacterial layer is composed of the following raw materials in weight percentage: Herba Cynanchii: 60%; Chitosan: 1%; Bletilla striata: 1%; Alum: 2%; Sanguisorba officinalis: 2%; Borneol: 34%.

[0019] Embodiment 5 The colloidal dressing layer is prepared according to the following steps: Step S1: Weighing the raw materials for the antibacterial layer: weighing corresponding weight portions of Herba Cynanchii, chitosan, Bletilla striata, Alum, Radix Sanguisorbae, and Borneol; Step S2: crushing the raw materials: pouring the raw materials weighed in step S1 into a crusher for crushing at a crushing speed of 500 rpm for 3 min to obtain a mixed powder A; Step S3: Weighing the raw materials of the colloidal dressing: Weigh corresponding weight portions of water for injection, sodium chloride, potassium chloride, liquid silicon dioxide, glycerol, hydroxyethyl cellulose, hydroxyethylene copolymer, sodium carboxymethyl cellulose, and sodium hydroxide for later use; Step S4: adding liquid silicon dioxide into the melt tank, stirring at a stirring speed of 50 r / min for 15 min; Step S5: pouring hydroxyethyl cellulose, hydroxyethylene copolymer and sodium carboxymethyl cellulose into the melt tank in step S4 and mixing for 10 minutes to obtain a liquid colloidal mixture B; Step S6: pouring water for injection, sodium chloride, potassium chloride, liquid silicon dioxide, glycerin and mixture B into a blender for stirring and mixing, and then adding sodium hydroxide to adjust the pH value to 7.0-8.0, and then obtaining mixture C; Step S7: pouring the mixture C in step S6 and the mixed powder A in step S1 into a kneader, setting the temperature to 100-120°C, stirring at 100 r / min for 15 min, and then placing the product of the kneader in a flat vulcanizer for 30 min, setting the temperature to 100°C, and then obtaining a colloidal dressing layer; Step S8: Apply the colloid dressing layer obtained in step S7 on the base layer, control the thickness to be 3 mm, and then cover it with release paper.

[0020] Comparative Experiment Example 1 Water absorption test The dressings produced in Examples 1 to 3 are cut into pieces with a length and width of 3 cm*3 cm, and the weight M1 of the sample after removing the release paper is weighed, and then the sample is placed in a cup containing 37° C., 9% isotonic saline; Then let it stand for 8 hours, then take out the sample from the cup with tweezers and clamp it, then hang it in the air for 10 seconds, and weigh the sample weight M2 again; Then calculate the water absorption rate, and the water absorption rate calculation formula is: ((M2-M1) / M1)*100% Example Water absorption (%) Embodiment 1 22.35 Embodiment 2 26.53 Embodiment 3 24.35 Embodiment 4 25.35 Comparative Experiment Example 2 Animal experiments Five experimental rabbits were selected, each weighing 1-1.5 kg. The hair on the right hind leg of each rabbit was shaved to form a square with an area of ​​4 cm*4 cm. Then, a scalpel was used to cut a square wound on the operating table with an area of ​​2 cm*2 cm and a depth of 0.3 cm.

[0021] At 8 a.m., one of the rabbits was smeared with saline solution every day (blank case); At the same time, the other three little white rabbits were sequentially affixed with the dressings produced in Example 1 to Example 3 (the dressings were changed once a day, at 4 pm every day).

[0022] Then calculate the wound healing rate on the 1st, 5th, 10th, and 20th day of treatment (calculated when the dressing is changed at 4 pm every day); The healing rate = (area before treatment - area after treatment) / area before treatment * 100%.

[0023] The results are as follows: Example Day 1 Day 5 Day 10 Day 20 Embodiment 1 8％ 48％ 84％ 100％ Embodiment 2 12％ 55％ 90％ 100％ Embodiment 3 7％ 52％ 92％ 100％ Embodiment 4 14％ 60％ 100％ 100％ Blank example 5％ 45％ 55％ 70％ In summary, the dressing produced in Example 2 has a good water absorption rate, so it can absorb the liquid exuded from the wound when used by the patient, and promote wound healing. At the same time, according to Comparative Experimental Example 2, the dressing produced in Example 4 can heal the wound faster. At the same time, the content of the added radix spatholobi and chitosan is also the highest, so the radix spatholobi and chitosan added in the present invention have good bactericidal function, can prevent wound infection, kill bacteria and reduce inflammation, and can also promote wound healing. At the same time, the setting of borneol can reduce the patient's pain, and the radix sanguisorbae can stop bleeding from the patient's wound, so it can also promote wound healing.

[0024] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A dressing patch for preventing wound infection, comprising a base layer, a colloid dressing layer and a release paper, wherein the colloid dressing layer is provided with a colloid dressing and an antibacterial layer, characterized in that: in, The antibacterial layer is composed of the following raw materials in terms of weight percentage: Pinwheel vegetable: 20%-80%; Chitosan: 5%-20%; Bletilla striata: 2%-10%; Alum: 6%-10%; Sanguisorba officinalis: 3%-10%; Borneol: 20%-50%; Wherein, the colloid dressing is composed of hydrogel; The hydrogel is composed of the following raw materials in weight percentage: 30% water for injection, 3% sodium chloride, 3% potassium chloride, 5% liquid silicon dioxide, 10% glycerol, 6% hydroxyethyl cellulose, 8% hydroxyethylene copolymer, 20% sodium carboxymethyl cellulose, and 15% sodium hydroxide.

2. A dressing for preventing wound infection according to claim 1, characterized in that: The antibacterial layer is composed of the following raw materials in terms of weight percentage: Pinwheel vegetable: 30%; Chitosan: 10%; Bletilla striata: 5%; Alum: 8%; Sanguisorba officinalis: 8%; Borneol: 39%.

3. A dressing for preventing wound infection according to claim 1, characterized in that: The antibacterial layer is composed of the following raw materials in terms of weight percentage: Pinwheel vegetable: 40%; Chitosan: 8%; Bletilla striata: 3%; Alum: 6%; Sanguisorba officinalis: 6%; Borneol: 37%.

4. A dressing for preventing wound infection according to claim 1, characterized in that: The antibacterial layer is composed of the following raw materials in terms of weight percentage: Pinwheel vegetable: 50%; Chitosan: 6%; Bletilla striata: 1%; Alum: 4%; Sanguisorba officinalis: 4%; Borneol: 35%.

5. The dressing for preventing wound infection according to claim 1, characterized in that: The antibacterial layer is composed of the following raw materials in terms of weight percentage: Pinwheel vegetable: 60%; Chitosan: 1%; Bletilla striata: 1%; Alum: 2%; Sanguisorba officinalis: 2%; Borneol: 34%.

6. A dressing for preventing wound infection according to claims 1-5, characterized in that: The colloidal dressing layer is prepared according to the following steps: Step S1: Weighing the raw materials for the antibacterial layer: weighing corresponding weight portions of Herba Cynanchii, chitosan, Bletilla striata, Alum, Radix Sanguisorbae, and Borneol; Step S2: crushing the raw materials: pouring the raw materials weighed in step S1 into a crusher for crushing at a crushing speed of 500 rpm for 3 min to obtain a mixed powder A; Step S3: Weighing the raw materials of the colloidal dressing: Weigh corresponding weight portions of water for injection, sodium chloride, potassium chloride, liquid silicon dioxide, glycerol, hydroxyethyl cellulose, hydroxyethylene copolymer, sodium carboxymethyl cellulose, and sodium hydroxide for later use; Step S4: adding liquid silicon dioxide into the melt tank, stirring at a stirring speed of 50 r / min for 15 min; Step S5: pouring hydroxyethyl cellulose, hydroxyethylene copolymer and sodium carboxymethyl cellulose into the melt tank in step S4 and mixing for 10 minutes to obtain a liquid colloidal mixture B; Step S6: pouring water for injection, sodium chloride, potassium chloride, liquid silicon dioxide, glycerin and mixture B into a blender for stirring and mixing, and then adding sodium hydroxide to adjust the pH value to 7.0-8.0, and then obtaining mixture C; Step S7: pouring the mixture C in step S6 and the mixed powder A in step S1 into a kneader, setting the temperature to 100-120°C, stirring at 100 r / min for 15 min, and then placing the product of the kneader in a flat vulcanizer for 30 min, setting the temperature to 100°C, and then obtaining a colloidal dressing layer; Step S8: Apply the colloid dressing layer obtained in step S7 on the base layer, control the thickness to be 3 mm, and then cover it with release paper.