Liquid phase pump solvent compression correction method, control device and liquid chromatograph

Abstract

The present application provides a liquid phase pump solvent compression correction method, a control device and a liquid chromatograph, which relate to the field of liquid chromatography technology. The method includes obtaining the compression mark of the current solvent, determining whether the liquid phase pump has reached the position of the calculated opening point, and if so, determining the target loss volume corresponding to the current solvent under the current system pressure according to the compression mark of the current solvent, the compression mark in the memory and the compression curve corresponding to the compression mark of each standard solvent, determining the position of the target opening point according to the target loss volume, and controlling the operation of the liquid phase pump according to the position of the target opening point. The present application determines the position of the target opening point according to the compression mark of the current solvent and the compression mark in the binding record, so the current solvent can be various standard solvents and mixed solvents mixed in any proportion, and the position of the opening point determined according to the compression mark of the current solvent is stable, the pulsation amplitude of the liquid phase pump is small, and the output result of the liquid chromatograph is accurate.

Description

Technical Field

[0001] The present application relates to the technical field of liquid chromatography, and in particular to a liquid phase pump solvent compression correction method, a control device and a liquid chromatograph. Background Art

[0002] The liquid phase pump is the power device of the liquid chromatograph, which is used to transfer the solvent from the liquid storage bottle to the detector. The opening point position of the liquid phase pump is calibrated based on various solvents to improve the accuracy of the liquid chromatograph's analysis and detection results.

[0003] The prior art provides a method for correcting the opening point position of a liquid phase pump under a single solvent, and uses a simple compensation algorithm to compensate for the opening point position. However, the method in the prior art cannot adapt to complex solvents, such as the correction of the opening point position of a liquid phase pump under a mixed solvent, resulting in a large pulsation amplitude of the liquid phase pump, leading to inaccurate output results of the liquid chromatograph. Summary of the invention

[0004] The purpose of the present application is to provide a liquid phase pump solvent compression correction method, a control device and a liquid chromatograph to address the deficiencies in the above-mentioned prior art, so as to solve the problems in the prior art that the correction is only suitable for a single solvent and the liquid phase pump has a large pulsation amplitude.

[0005] To achieve the above objectives, the technical solutions adopted in this application are as follows:

[0006] In a first aspect, the present application provides a method for correcting solvent compression of a liquid phase pump, the method comprising:

[0007] Get the compression identifier of the current solvent;

[0008] Determine whether the liquid phase pump has reached the position of the calculated opening point;

[0009] If so, determine the target loss volume corresponding to the current solvent under the current system pressure according to the compression identifier of the current solvent, the compression identifier of at least one standard solvent in the binding record stored in the memory, and the compression curve corresponding to the compression identifier of each standard solvent, wherein the compression curve is used to characterize the corresponding relationship between the system pressure and the loss volume;

[0010] Determine the position of the target opening point according to the target loss volume;

[0011] The operation of the liquid phase pump is controlled according to the position of the target opening point.

[0012] Optionally, determining the target loss volume corresponding to the current solvent under the current system pressure according to the compression identifier of the current solvent, the compression identifier of at least one standard solvent in the binding record stored in the memory, and the compression curves corresponding to the compression identifiers of the standard solvents includes:

[0013] Get the current system pressure;

[0014] Determining whether there is a target compression identifier that is the same as the compression identifier of the current solvent among the compression identifiers stored in the memory;

[0015] If yes, taking the compression curve of the target compression mark as the first compression curve, and determining the target loss volume according to the first compression curve and the current system pressure;

[0016] If not, the compression curves corresponding to the two compression marks adjacent to the compression mark of the current solvent in the memory are used as the second compression curve and the third compression curve, and the target loss volume is determined according to the second compression curve, the third compression curve and the current system pressure.

[0017] Optionally, determining the target loss volume according to the first compression curve and the current system pressure includes:

[0018] The loss volume corresponding to the current system pressure in the first compression curve is used as the target loss volume.

[0019] Optionally, determining the target loss volume according to the second compression curve, the third compression curve and the current system pressure includes:

[0020] Using the loss volume corresponding to the current system pressure in the second compression curve as the first loss volume;

[0021] taking the loss volume corresponding to the current system pressure in the third compression curve as the second loss volume;

[0022] The target loss volume is determined according to the proportional relationship between the compression mark of the current solvent and two adjacent compression marks, as well as the first loss volume and the second loss volume.

[0023] Optionally, determining the target loss volume according to the proportional relationship between the compression mark of the current solvent and two adjacent compression marks, as well as the first loss volume and the second loss volume, includes:

[0024] Taking the difference between the compression mark of the current solvent and the smallest compression mark of two adjacent compression marks as the first difference, and taking the difference between the two adjacent compression marks as the second difference;

[0025] taking a ratio of the first difference to the second difference as a target ratio;

[0026] Calculating the difference between the second loss volume and the first loss volume to obtain a third difference, wherein the second loss volume is greater than the first loss volume;

[0027] The product of the third difference and the target ratio, and the sum of the first loss volume are taken as the target loss volume.

[0028] Optionally, before obtaining the compression identifier of the current solvent, the method further includes:

[0029] Determine the flow rate of the first standard solvent input into the liquid phase pump, determine the positions of a plurality of stable opening points according to the pressure curve of the system pressure of the liquid phase pump, and determine the loss volumes corresponding to a plurality of system pressures according to the positions of the plurality of stable opening points, wherein the stable opening points are used to characterize the stability of the pressure curve;

[0030] According to a plurality of system pressures and loss volumes corresponding to the system pressures, a compression curve of the first standard solvent is generated by fitting, a compression identifier and a compression curve of the first standard solvent are bound, and the binding record is stored in the memory.

[0031] Optionally, determining the flow rate of the first standard solvent input into the liquid phase pump, determining the positions of a plurality of stable opening points according to a pressure curve of a system pressure of the liquid phase pump, and determining the loss volumes corresponding to a plurality of system pressures according to the positions of the plurality of stable opening points, comprises:

[0032] A. Set the calibration point count to an initial value and obtain a preset calibration point quantity threshold;

[0033] B. setting the flow rate of the first standard solvent;

[0034] C. Adjust the position of the current opening point, and determine whether the current opening point is stable according to the pressure curve of the system pressure of the liquid phase pump. If so, execute step D, otherwise, re-execute step C;

[0035] D. Record the position of the current opening point and the current system pressure, determine the current loss volume according to the position of the current opening point, record the current system pressure and the current loss volume corresponding to the current system pressure, and update the correction point count;

[0036] E. Determine whether the calibration point count reaches the calibration point quantity threshold, if so, end the loop, if not, re-execute step B;

[0037] Optionally, determining the position of the target opening point according to the target loss volume includes:

[0038] Determine whether compensation is required;

[0039] If so, the position of the initial opening point is calculated according to the target loss volume, and a compensation value is determined according to a plurality of historical pressure curves of the liquid phase pump, and the position of the target opening point is determined according to the compensation value and the position of the initial opening point;

[0040] If not, the position of the target opening point is calculated based on the target loss volume.

[0041] In a second aspect, the present application provides a liquid phase pump solvent compression correction device, the device comprising:

[0042] An acquisition module is used to obtain the compression identifier of the current solvent;

[0043] A judgment module, used to judge whether the liquid phase pump reaches the position of the calculated opening point;

[0044] A first determination module is used to determine, if yes, a target loss volume corresponding to the current solvent under the current system pressure according to a compression identifier of the current solvent, a compression identifier of at least one standard solvent in a binding record stored in a memory, and a compression curve corresponding to the compression identifier of each standard solvent, wherein the compression curve is used to characterize the corresponding relationship between the system pressure and the loss volume;

[0045] A second determination module is used to determine the position of the target opening point according to the target loss volume;

[0046] The control module is used to control the operation of the liquid phase pump according to the position of the target opening point.

[0047] Optionally, the first determining module is specifically configured to:

[0048] Get the current system pressure;

[0049] Determining whether there is a target compression identifier that is the same as the compression identifier of the current solvent among the compression identifiers stored in the memory;

[0050] If yes, taking the compression curve of the target compression mark as the first compression curve, and determining the target loss volume according to the first compression curve and the current system pressure;

[0051] If not, the compression curves corresponding to the two compression marks adjacent to the compression mark of the current solvent in the memory are used as the second compression curve and the third compression curve, and the target loss volume is determined according to the second compression curve, the third compression curve and the current system pressure.

[0052] Optionally, the first determining module is specifically configured to:

[0053] The loss volume corresponding to the current system pressure in the first compression curve is used as the target loss volume.

[0054] Optionally, the first determining module is specifically configured to:

[0055] Using the loss volume corresponding to the current system pressure in the second compression curve as the first loss volume;

[0056] taking the loss volume corresponding to the current system pressure in the third compression curve as the second loss volume;

[0057] The target loss volume is determined according to the proportional relationship between the compression mark of the current solvent and two adjacent compression marks, as well as the first loss volume and the second loss volume.

[0058] Optionally, the first determining module is specifically configured to:

[0059] Taking the difference between the compression mark of the current solvent and the smallest compression mark of two adjacent compression marks as the first difference, and taking the difference between the two adjacent compression marks as the second difference;

[0060] taking a ratio of the first difference to the second difference as a target ratio;

[0061] Calculating the difference between the second loss volume and the first loss volume to obtain a third difference, wherein the second loss volume is greater than the first loss volume;

[0062] The product of the third difference and the target ratio, and the sum of the first loss volume are taken as the target loss volume.

[0063] Optionally, the acquisition module is further used for:

[0064] Determine the flow rate of the first standard solvent input into the liquid phase pump, determine the positions of a plurality of stable opening points according to the pressure curve of the system pressure of the liquid phase pump, and determine the loss volumes corresponding to a plurality of system pressures according to the positions of the plurality of stable opening points, wherein the stable opening points are used to characterize the stability of the pressure curve;

[0065] According to a plurality of system pressures and loss volumes corresponding to the system pressures, a compression curve of the first standard solvent is generated by fitting, a compression identifier and a compression curve of the first standard solvent are bound, and the binding record is stored in the memory.

[0066] Optionally, the acquisition module is further configured to:

[0067] A. Set the calibration point count to an initial value and obtain a preset calibration point quantity threshold;

[0068] B. setting the flow rate of the first standard solvent;

[0069] C. Adjust the position of the current opening point, and determine whether the current opening point is stable according to the pressure curve of the system pressure of the liquid phase pump. If so, execute step D, otherwise, re-execute step C;

[0070] D. Record the position of the current opening point and the current system pressure, determine the current loss volume according to the position of the current opening point, record the current system pressure and the current loss volume corresponding to the current system pressure, and update the correction point count;

[0071] E. Determine whether the calibration point count reaches the calibration point quantity threshold, if so, end the loop, if not, re-execute step B;

[0072] Optionally, the second determining module is specifically configured to:

[0073] Determine whether compensation is required;

[0074] If so, the position of the initial opening point is calculated according to the target loss volume, and a compensation value is determined according to a plurality of historical pressure curves of the liquid phase pump, and the position of the target opening point is determined according to the compensation value and the position of the initial opening point;

[0075] If not, the position of the target opening point is calculated based on the target loss volume.

[0076] In a third aspect, the present application provides a control device comprising: a processor and a memory, wherein the memory stores machine-readable instructions executable by the processor, and when the control device is running, the processor executes the machine-readable instructions to perform the steps of the liquid phase pump solvent compression correction method as described in the first aspect.

[0077] In a fourth aspect, the present application provides a liquid chromatograph, which includes a control device and a liquid phase pump as shown in the third aspect, and the control device is connected to the liquid phase pump.

[0078] In a fifth aspect, the present application provides a computer-readable storage medium having a computer program stored thereon, and when the computer program is executed by a processor, the steps of the above-mentioned liquid phase pump solvent compression correction method are executed.

[0079] The beneficial effect of the present application is that when the liquid phase pump reaches the calculated opening point position, the target loss volume corresponding to the current solvent under the current system pressure is determined according to the obtained compression identifier, the compression identifier of at least one standard solvent in the binding record stored in the memory, and the compression curve corresponding to the compression representation of each standard solvent, so that during the calling process, since the compression curve is determined according to the compression identifier of the current solvent and the compression identifier in the binding record, the position of the target opening point is determined, so the current solvent can be various standard solvents and mixed solvents mixed in any proportion, and the position of the opening point determined according to the compression identifier of the current solvent is stable, the operation of the liquid phase pump is controlled according to the position of the target opening point, the pulsation amplitude of the liquid phase pump is small, and the output result of the liquid chromatograph is accurate. BRIEF DESCRIPTION OF THE DRAWINGS

[0080] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present application and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0081] Figure 1 It is a structural schematic diagram of a liquid phase pump provided in an embodiment of the present application;

[0082] Figure 2 It is a flow chart of a liquid phase pump solvent compression correction method provided in an embodiment of the present application;

[0083] Figure 3 It is a schematic diagram of a process for determining a target loss volume provided in an embodiment of the present application;

[0084] Figure 4 is another schematic diagram of a process for determining a target loss volume provided in an embodiment of the present application;

[0085] Figure 5 is another schematic diagram of a process for determining a target loss volume provided in an embodiment of the present application;

[0086] Figure 6 It is a schematic diagram of a flow chart of determining the position of a target opening point provided in an embodiment of the present application;

[0087] Figure 7 It is a flow chart of another method for correcting solvent compression of a liquid phase pump provided in an embodiment of the present application;

[0088] Figure 8 is a flow chart of determining loss volumes corresponding to multiple system pressures provided in an embodiment of the present application;

[0089] Fig. 9 It is a schematic flow chart of a calibration process of a solvent pre-calibration method provided in an embodiment of the present application;

[0090] Fig.10 It is a structural schematic diagram of a liquid phase pump solvent compression correction device provided in an embodiment of the present application;

[0091] Fig.11 It is a structural schematic diagram of a control device provided in an embodiment of the present application. DETAILED DESCRIPTION

[0092] To make the purpose, technical scheme and advantages of the embodiments of the present application clearer, the technical scheme in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. It should be understood that the drawings in the present application only serve the purpose of explanation and description and are not used to limit the scope of protection of the present application. In addition, it should be understood that the schematic drawings are not drawn in real proportion. The flowchart used in this application shows the operations implemented according to some embodiments of the present application. It should be understood that the operations of the flowchart can be implemented out of sequence, and the steps without logical context can be reversed in order or implemented simultaneously. In addition, those skilled in the art can add one or more other operations to the flowchart under the guidance of the content of the present application, or remove one or more operations from the flowchart.

[0093] In addition, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. The components of the embodiments of the present application described and shown in the drawings here can be arranged and designed in various configurations. Therefore, the following detailed description of the embodiments of the present application provided in the drawings is not intended to limit the scope of the application claimed for protection, but merely represents the selected embodiments of the present application. Based on the embodiments of the present application, all other embodiments obtained by those skilled in the art without making creative work belong to the scope of protection of the present application.

[0094] It should be noted that the term "comprising" will be used in the embodiments of the present application to indicate the existence of the features declared thereafter, but does not exclude the addition of other features.

[0095] The prior art only provides correction of the opening point position of the liquid phase pump under a single standard solvent, and is unable to adapt to the correction of the opening point position of the liquid phase pump under complex solvents. In addition, the opening point position calculated by a simple compensation algorithm has low accuracy, resulting in a large pulsation amplitude of the liquid phase pump, leading to inaccurate output results of the liquid chromatograph.

[0096] Based on this, the present application proposes a liquid phase pump solvent compression correction method, which determines the target loss volume corresponding to the current system pressure according to the compression identifier of the current solvent, the compression identifier of at least one standard solvent in the binding record stored in the memory, and the compression curve corresponding to each compression identifier, and then determines the position of the target opening point according to the target loss volume, and controls the operation of the liquid phase pump according to the position of the target opening point. The present application does not limit the type of the current solvent. It only needs to determine the target loss volume corresponding to the current solvent under the current system pressure according to the compression identifier of the current solvent, the compression identifier of at least one standard solvent in the binding record stored in the memory, and the compression curve corresponding to the compression identifier. Since the determined target loss volume is accurate, the position of the target opening point determined based on the target loss volume is also more stable, the pulsation amplitude of the liquid phase pump is small, and the output result of the liquid chromatograph is accurate.

[0097] Before introducing the liquid phase pump solvent compression correction method, the application scenario of the liquid phase pump solvent compression correction method is first introduced.

[0098] The liquid phase pump solvent compression correction method is applied to a control device with computing capability connected to the liquid phase pump. After the liquid phase pump leaves the factory, the user can pre-perform the solvent pre-correction process, that is, input multiple solvents into the liquid phase pump respectively, and the control device performs compression correction on various solvents to obtain the compression curve corresponding to each solvent, and after binding each compression curve with the corresponding compression identifier, the binding records corresponding to multiple standard solvents are stored in the memory. During the calling process, the user inputs or selects the compression identifier of the current solvent in the interactive interface of the liquid chromatograph. The compression identifier can be the identifier stored by the user during the solvent pre-correction process. After the control device starts the infusion pump, it determines the target opening point position according to the compression identifier of the current solvent and the binding record in the memory, and controls the operation of the liquid phase pump. It is worth mentioning that when the instrument is aged or a new solvent needs to be calibrated, the solvent pre-correction process can be performed again to obtain a more accurate compression curve.

[0099] Next, refer to Figure 1 The working principle of the liquid phase pump is introduced. Figure 1 Schematic diagram of the structure of a liquid phase pump provided in the embodiment of the present application. Figure 1 As shown, the liquid phase pump is composed of a pump head, a plunger rod, a sealing ring, an inlet check valve, an outlet check valve and a pump chamber. Among them, the pump head is the solvent transmission unit at the front end of the liquid phase pump, the plunger rod is driven by the driving unit of the infusion pump, the sealing ring is the dynamic sealing component of the pump head, the inlet check valve is a one-way open valve component for drawing the solvent into the inlet, the outlet check valve is a one-way open valve component for compressing the solvent and pushing it out of the outlet, and the pump chamber is the space cavity where the solvent in the pump head is located when both the inlet check valve and the outlet check valve are closed.

[0100] When the liquid phase pump is working, the driving unit drives the plunger rod to move backward, the pump chamber is depressurized, the outlet check valve is closed, and the plunger rod continues to move backward until the pump chamber is depressurized to a pressure lower than the normal pressure before the inlet check valve. The inlet check valve opens and starts pumping until the pumping stroke is completed. The driving unit drives the plunger rod forward, the solvent is compressed to generate pressure, the inlet check valve is closed under pressure, and the driving plunger rod continues to move forward. As the compression increases, the pump chamber pressure increases. When the pump chamber pressure is greater than the system pressure, the outlet check valve opens and the solvent is output.

[0101] The system pressure is the pressure borne by the downstream side of the outlet check valve, and the opening point is the stroke position when the outlet check valve opens.

[0102] It is worth mentioning that Figure 1 A single pump is shown, and the method is not limited to the type of pump to which it is applied. For example, the method can be applied to parallel pumps, series pumps, etc.

[0103] Next, refer to Figure 2 The liquid phase pump solvent compression correction method is introduced. Figure 2 It is a flow chart of a liquid phase pump solvent compression correction method provided in an embodiment of the present application.

[0104] S201. Obtain the compression identifier of the current solvent.

[0105] Optionally, the current solvent may be a single solvent or a mixed solvent.

[0106] Optionally, the compression identifier of the current solvent may be the compression coefficient of the current solvent, or an identification code of the current solvent and an estimated compression coefficient of the current solvent. Specifically, if the current solvent is a standard solvent, the compression coefficient of the current solvent may be used as the compression identifier of the current solvent. If the current solvent is a mixed solvent, a unique identification code and the estimated compression coefficient of the current solvent input by the user may be used as the compression identifier of the current solvent. The standard solvent may be a solvent whose compression curve is determined by a solvent pre-calibration process. The standard solvent may be a single solvent or a mixed solvent.

[0107] Optionally, the user calibrates multiple standard solvents during the solvent pre-calibration process. The user can select the compression identifier of the standard solvent in the calibration process as the compression identifier of the current solvent on the interactive interface, or enter the compression identifier of the current solvent, that is, the identification code and estimated compression coefficient.

[0108] S202, determining whether the liquid phase pump has reached the position of the calculated opening point.

[0109] Optionally, during operation of the liquid phase pump, the plunger rod can be driven by a driving unit, and the driving unit can be, for example, a cam or a screw. Taking the driving unit as a cam as an example, the cam rotates around a point as an axis to drive the plunger rod to pump and discharge liquid. If one rotation of the cam is regarded as a stroke cycle, then a stroke cycle includes a pumping section and a discharging section, and the discharging section is located after the pumping section. Based on this, a point before the discharging section can be used as a calculation start point in advance. As an optional implementation, the 0 point of a stroke cycle can be used as the calculation start point.

[0110] S203. If so, determine the target loss volume corresponding to the current solvent under the current system pressure based on the compression identifier of the current solvent, the compression identifier of at least one standard solvent in the binding record stored in the memory, and the compression curve corresponding to the compression identifier of each standard solvent. The compression curve is used to characterize the corresponding relationship between the system pressure and the loss volume.

[0111] As an optional implementation, the compression identifier of at least one standard solvent in the binding record stored in the memory is determined based on the compression identifier of the current solvent, and then the target loss volume corresponding to the current solvent under the current system pressure is determined based on the current system pressure and the compression curve corresponding to the determined compression identifier.

[0112] Optionally, the compression curve may represent the corresponding relationship between a plurality of system pressures and a plurality of loss volumes corresponding to a compression mark. It is worth mentioning that if the compression coefficients of different solvents are the same, the compression curves are the same.

[0113] Optionally, the loss volume is the product of the displacement of the plunger rod from the main displacement point to the opening point and the cross-sectional area of ​​the pump chamber, wherein the main displacement point is the travel point where the plunger rod is pushed forward and begins to compress the solvent.

[0114] Among them, each compression curve can be determined by a pre-executed solvent pre-calibration process. Specifically, the standard solvent is input into the liquid phase pump, the control device performs compression calibration on the standard solvent, and records multiple system pressures and corresponding loss volumes during the calibration process, and the compression curve corresponding to the compression mark of the standard solvent is obtained by fitting according to the multiple system pressures and the corresponding loss volumes.

[0115] It is worth mentioning that the compression curve is bound to the compression identifier. In the process of determining the target loss volume, it is only necessary to determine the matching relationship between the compression identifier of the current solvent and the compression identifiers in each binding record in the memory. Since the compression identifier can be a compression coefficient, it can also be an identification code of the current solvent and an estimated compression coefficient of the current solvent. Therefore, when determining the target loss volume, the target loss volume corresponding to the current solvent under the current system pressure is determined based on the compression coefficient or estimated compression coefficient represented by the compression identifier of the current solvent, the compression coefficient represented by at least one compression identifier in the binding record stored in the memory, and the compression curve corresponding to the compression identifier.

[0116] Optionally, when the driving unit drives the plunger rod to move, each cycle corresponds to a system pressure, and the target loss volume is the loss volume corresponding to the current system pressure in the current cycle.

[0117] S204. Determine the position of the target opening point according to the target loss volume.

[0118] Optionally, since the loss volume is the product of the displacement of the plunger rod from the main discharge point to the opening point and the cross-sectional area of ​​the pump chamber, the position of the target opening point can be calculated based on the target loss volume, the pump chamber cross-section and the main discharge point position.

[0119] It should be understood that for solvents with different compressibility factors, the location of the target opening point may be different.

[0120] S205. Control the operation of the liquid phase pump according to the position of the target opening point.

[0121] Specifically, after determining the position of the target opening point, the control device controls the driving unit to change speed, thereby adapting the position of the target opening point, until the plunger rod reaches the position of the target opening point.

[0122] In this embodiment, when the liquid phase pump reaches the calculated starting point position, the target loss volume corresponding to the current solvent under the current system pressure is determined according to the obtained compression identifier, the compression identifier of at least one standard solvent in the binding record stored in the memory, and the compression curve corresponding to the compression representation of each standard solvent. Therefore, during the calling process, since the compression curve is determined according to the compression identifier of the current solvent and the compression identifier in the binding record, the position of the target starting point is determined. Therefore, the current solvent can be various standard solvents and mixed solvents mixed in any proportion, and the position of the starting point determined according to the compression identifier of the current solvent is stable. The operation of the liquid phase pump is controlled according to the position of the target starting point, the pulsation amplitude of the liquid phase pump is small, and the output result of the liquid chromatograph is accurate.

[0123] Next, refer to Figure 3The specific process of determining the target loss volume corresponding to the current solvent under the current system pressure in the above step S203 is introduced. Figure 3 It is a schematic diagram of a process for determining a target loss volume provided in an embodiment of the present application.

[0124] S301. Obtain current system pressure.

[0125] Optionally, the control device obtains the current system pressure of the current wheel acquired in real time.

[0126] S302: Determine whether there is a target compression identifier that is the same as the compression identifier of the current solvent among the compression identifiers stored in the memory.

[0127] The target compression identifier is one of the compression identifiers stored in the storage.

[0128] As an optional implementation, the compression identifiers in the memory are traversed, and for the current compression identifier traversed, it is determined whether the current compression identifier is the same as the compression identifier of the current solvent. If so, the current compression identifier is used as the target compression identifier.

[0129] It is worth noting that the current solvent can be a standard solvent or a mixed solvent. When the current solvent is a standard solvent, the compression coefficient of the current solvent can be used as a compression identifier, so step S302 is specifically to determine whether the compression coefficients represented by the compression identifiers stored in the memory contain a target compression identifier that is the same as the compression coefficient represented by the compression identifier of the current solvent. When the current solvent is a mixed solvent, the compression coefficient of the current solvent can be an identification code and an estimated compression coefficient of the current solvent. Therefore, step S302 is specifically to determine whether the estimated compression coefficients represented by the compression identifiers stored in the memory contain a target compression identifier that is the same as the compression coefficient represented by the compression identifier of the current solvent.

[0130] S303: If yes, use the compression curve of the target compression mark as the first compression curve, and determine the target loss volume according to the first compression curve and the current system pressure.

[0131] Specifically, if yes, the target compression curve in the binding record where the target compression identifier is located is used as the first compression curve. The first compression curve represents the corresponding relationship between the system pressure and the loss volume of the solvent with the compression coefficient corresponding to the target compression identifier in the hydraulic pump.

[0132] S304, if not, taking the compression curves corresponding to the two compression marks adjacent to the compression mark of the current solvent in the memory as the second compression curve and the third compression curve, and determining the target loss volume according to the second compression curve, the third compression curve and the current system pressure.

[0133] As an optional implementation, the two compression marks adjacent to the compression mark of the current solvent may be compression marks corresponding to two compression coefficients adjacent to the compression coefficient represented by the compression mark of the current solvent.

[0134] As another optional implementation, the two compression marks adjacent to the compression mark of the current solvent may be compression marks corresponding to two compression coefficients adjacent to the estimated compression coefficient represented by the compression mark of the current solvent.

[0135] For example, the compression coefficient represented by the compression identifier of the current solvent or the estimated compression coefficient is 115, and the compression coefficients represented by the compression identifiers stored in the memory are 46, 120 and 150 respectively, then the compression curves corresponding to the compression identifiers with compression coefficients of 46 and 120 are used as the second compression curve and the third compression curve.

[0136] As an optional implementation, the target loss volume is determined according to the loss volume corresponding to the current system pressure in the second compression curve and the loss volume corresponding to the current system pressure in the third compression curve.

[0137] In this embodiment, the target loss volume is determined by judging whether there is a target compression identifier that is the same as the current solvent pressure identifier among the compression identifiers stored in the memory. Therefore, regardless of whether the current solvent can be various standard solvents or mixed solvents mixed in any proportion, the target loss volume can be determined based on the compression identifier and compression curve stored in the memory to determine the accurate position of the target opening point and reduce the pulsation amplitude.

[0138] As an optional implementation, the specific implementation method of determining the target loss volume according to the first compression curve and the current system pressure in the above step S303 is as follows: the loss volume corresponding to the current system pressure in the first compression curve is used as the target loss volume.

[0139] Exemplarily, the current system pressure is 10, and the loss volume corresponding to the current system pressure of 10 in the first compression curve is used as the target loss volume.

[0140] In this embodiment, the loss volume corresponding to the current system pressure in the first compression curve is used as the target loss volume, thereby determining the precise loss volume of the current solvent under the current system pressure.

[0141] Next, refer to Figure 4 The specific steps of determining the target loss volume according to the second compression curve, the third compression curve and the current system pressure in the above step S304 are introduced. Figure 4 It is another flow chart of determining the target loss volume provided in an embodiment of the present application.

[0142] S401. Taking the loss volume corresponding to the current system pressure in the second compression curve as the first loss volume.

[0143] Exemplarily, if the current system pressure is 10, the loss volume corresponding to the current system pressure of 10 in the second compression curve is used as the first loss volume.

[0144] S402: Use the loss volume corresponding to the current system pressure in the third compression curve as the second loss volume.

[0145] Exemplarily, the current system pressure is 10, and the loss volume corresponding to the current system pressure of 10 in the third compression curve is used as the second loss volume.

[0146] S403: Determine a target loss volume according to a proportional relationship between the compression mark of the current solvent and two adjacent compression marks, as well as the first loss volume and the second loss volume.

[0147] Optionally, the proportional relationship between the compression mark of the current solvent and two adjacent compression marks is the ratio of the difference between the compression mark of the current solvent and the smallest compression mark of the two adjacent compression marks to the difference between the two adjacent compression marks.

[0148] Optionally, the target loss volume may be determined based on a linear interpolation calculation method according to the proportional relationship between the compression mark of the current solvent and two adjacent compression marks, as well as the first loss volume and the second loss volume. Specifically, the proportional relationship between the compression mark of the current solvent and two adjacent compression marks is calculated, and then the difference between the first loss volume and the second loss volume is calculated, and the target loss volume is determined based on the proportional relationship, the difference, and the first loss volume.

[0149] In this embodiment, the target loss volume is determined by determining the first loss volume and the second loss volume, so that the precise opening point position can be determined for solvents that have not been pre-calibrated, so that the liquid phase pump can adapt to various types of solvents with a small pulse amplitude.

[0150] Further, refer to Figure 5 How to determine the target loss volume in the above step S403 according to the proportional relationship between the compression mark of the current solvent and the two adjacent compression marks, as well as the first target loss volume and the second target loss volume is introduced. Figure 5 It is another flow chart of determining the target loss volume provided in an embodiment of the present application.

[0151] S501. Taking the difference between the compression mark of the current solvent and the smallest compression mark of two adjacent compression marks as a first difference, and taking the difference between the two adjacent compression marks as a second difference.

[0152] Specifically, the difference between the compression coefficient represented by the compression mark of the current solvent or the estimated compression coefficient and the smallest compression coefficient represented by two adjacent compression marks is taken as the first difference, and the difference between the compression coefficients represented by two adjacent compression marks is taken as the second difference.

[0153] Exemplarily, the compression coefficient represented by the compression mark of the current solvent is 30, and the compression coefficients represented by the two adjacent compression marks are 10 and 50 respectively. Then the compression coefficient represented by the smallest compression mark of the two adjacent compression marks is 10, the first difference is 20, and the second difference is 40.

[0154] S502: Taking the ratio of the first difference to the second difference as the target ratio.

[0155] Exemplarily, if the first difference is 20 and the second difference is 40, the target ratio is 0.5.

[0156] S503. Calculate the difference between the second loss volume and the first loss volume to obtain a third difference, where the second loss volume is greater than the first loss volume.

[0157] Exemplarily, if the first loss volume is 100 and the second loss volume is 200, the third difference is 100.

[0158] S504: The product of the third difference and the target ratio and the sum of the first loss volume are taken as the target loss volume.

[0159] Exemplarily, if the target ratio is 0.5, the third difference is 100, and the first loss volume is 100, then the target loss volume is 150.

[0160] In this embodiment, the target loss volume is determined by calculating the first difference, the second difference and the third difference, so that the precise opening point position can be determined for solvents that have not been pre-calibrated, so that the liquid phase pump can adapt to various types of solvents with a small pulse amplitude.

[0161] As an optional implementation, refer to Figure 6 The step of determining the position of the target opening point according to the target loss volume in the above step S204 is introduced. Figure 6 It is a schematic diagram of a flow chart for determining the position of a target opening point provided in an embodiment of the present application.

[0162] S601: Determine whether compensation is required.

[0163] Optionally, whether compensation is required can be determined based on the type of the liquid phase pump. Specifically, when the liquid phase pump is a unit pump or a low-pressure quaternary pump, etc., and the operating conditions of the pumps do not interfere with each other, it can be determined that compensation is required.

[0164] Optionally, compensating the liquid phase pump may specifically be compensating the position of the opening point according to the bulge of the output pulse curve of the liquid phase pump.

[0165] S602: If yes, the position of the initial opening point is calculated according to the target loss volume, and the compensation value is determined according to multiple historical pressure curves of the liquid phase pump, and the position of the target opening point is determined according to the compensation value and the position of the initial opening point.

[0166] Specifically, the position of the initial opening point can be calculated according to the target loss volume, the cross section of the pump cavity and the position of the main discharge point.

[0167] Optionally, the compensation value is determined according to the band values ​​of multiple historical pressure curves of the liquid phase pump. The multiple historical pressure curves may be pressure curves output by the liquid phase pump in a preset historical round, and the preset historical round may be 5 rounds, that is, the 5 historical pressure curves may be pressure curves output by the liquid phase pump in 5 rounds before the current round. The compensation value is the compensation value of the position of the opening point.

[0168] Optionally, the sum of the position of the initial opening point and the compensation value is used as the position of the target opening point.

[0169] S603: If not, the position of the target opening point is calculated based on the target loss volume.

[0170] If compensation is not required, the position of the target opening point can be calculated based on the target loss volume, the pump chamber cross section and the main discharge point position.

[0171] In this embodiment, when compensation is needed, the compensation value is determined based on multiple historical pressure curves of the liquid phase pump, and the position of the target opening point is determined based on the calculated position of the initial opening point and the compensation value. Thus, the position of the initial opening point is compensated without the liquid phase pump working conditions interfering with each other, thereby obtaining a more accurate position of the target opening point. The position of the opening point after compensation takes into account the fluctuation of the historical pressure curve, thereby more accurately positioning the opening point of the infusion pump and reducing the pulsation of the infusion pump.

[0172] As an optional implementation, Figure 7 FIG. 1 is a flow chart of another method for correcting solvent compression of a liquid phase pump provided in an embodiment of the present application. Figure 7As shown, the user inputs or selects the compression mark of the current solvent through the interactive interface, the control device starts the liquid phase pump, and the plunger rod starts to push. During this process, it is determined whether the position of the calculated opening point has been reached. If not, the plunger rod continues to be pushed to determine whether the position of the calculated opening point has been reached. If so, the current system pressure is obtained, and it is determined whether there is a target compression mark that is the same as the compression mark of the current solvent among the compression marks stored in the memory. If so, the compression curve of the target compression mark is used as the first compression curve, and the loss volume corresponding to the current system pressure in the first compression curve is used as the target loss volume. If not, the compression curves corresponding to the two compression marks adjacent to the compression mark of the current solvent in the memory are used as the second compression curve and the third compression curve. The first loss volume and the second loss volume corresponding to the current system pressure are determined according to the second compression curve and the third compression curve. The target loss volume is determined according to the proportional relationship between the compression mark of the current solvent and the two adjacent compression marks, as well as the first loss volume and the second loss volume. After determining the target loss volume, determine whether compensation is required. If necessary, calculate the compensation value based on multiple historical pressure curves, and calculate the position of the initial opening point based on the target loss volume. Determine the position of the target opening point based on the position of the initial opening point and the compensation value. If compensation is not required, directly determine the position of the target opening point based on the target loss volume, and then control the drive unit speed change based on the position of the target opening point to adapt to the position of the target opening point. The above process is a method for determining the position of the target opening point in the current round. Each round needs to execute the above steps of obtaining the current system pressure and the subsequent steps to reduce the output pulsation amplitude of the liquid phase pump.

[0173] After introducing how to call the process in the liquid phase pump solvent compression correction method, the following describes how to perform the solvent pre-calibration process. When the liquid phase pump is aged, the user can update the compression curve of each solvent through the solvent pre-calibration process to make the compression curve adapt to the current liquid phase pump compression situation. Alternatively, pre-calibrate a new solvent or a mixed solvent to obtain a new compression curve, and then directly call the compression curve later, so that the calculated target opening point position is more accurate.

[0174] Optionally, the flow rate of the first standard solvent input into the liquid phase pump is determined, the positions of multiple stable opening points are determined based on the pressure curve of the system pressure of the liquid phase pump, and the loss volumes corresponding to multiple system pressures are determined based on the positions of the multiple stable opening points. The stable opening points are used to characterize the stability of the pressure curve.

[0175] Optionally, before determining the flow rate of the first standard solvent input into the liquid phase pump, the user prepares the solvent first, and then enters the compression identifier in the interactive interface. Connect a back pressure device after the liquid phase pump, open the vent valve, and close the vent valve after emptying the infusion pump. Start determining the flow rate.

[0176] Optionally, the first standard solvent is any standard solvent stored in the memory during the calling process, and the first standard solvent may be a single solvent or a mixed solvent.

[0177] Optionally, after determining the flow rate of the first standard solvent input into the liquid phase pump, the control device controls the plunger rod to push so that the first standard solvent flows at the determined flow rate.

[0178] As an optional implementation, the opening point position can be preset, and then the pressure curve of the system pressure of the liquid phase pump at the preset opening point position is stable. If it is not stable, the preset opening point position is adjusted until the pressure curve is stable, and the opening point position corresponding to the stable pressure curve is used as the stable opening point position. The pressure curve is stable when the bulge amplitude of the pressure curve is not greater than the preset bulge amplitude threshold.

[0179] Optionally, by adjusting the flow rate of the first standard solvent multiple times, multiple system pressures and corresponding stable opening point positions can be obtained, thereby obtaining multiple loss volumes.

[0180] Optionally, according to a plurality of system pressures and loss volumes corresponding to the system pressures, a compression curve of the first standard solvent is fitted and generated, a compression identifier and the compression curve of the first standard solvent are bound, and the binding record is stored in a memory.

[0181] Optionally, a quasi-linear fitting is performed on a plurality of system pressures and the loss volumes corresponding to the plurality of system pressures to generate a compression curve corresponding to the first standard solvent.

[0182] Optionally, the compression mark of the first standard solvent and the binding result obtained by the compression curve are used as the binding record.

[0183] It is worth noting that after the compression curve of the first standard solvent is generated according to the multiple system pressures and the loss volume corresponding to the system pressures, it can be judged whether the fitting effect of the compression curve meets the requirements according to the linear correlation of the compression curve. The higher the linear correlation, the better the compression curve fitting effect, and the lower the linear correlation, the worse the compression curve fitting effect.

[0184] Specifically, after the compression curve is fitted, the expression formula and linear correlation of the compression curve can be determined. Next, two methods of determining the fitting effect of the compression curve according to the linear correlation are introduced.

[0185] As an optional implementation, a linear correlation threshold is preset. If the linear correlation of the compression curve obtained by fitting is greater than the linear correlation threshold, it means that the compression curve fitting effect meets the requirements and can be called. If the linear correlation of the compression curve is less than or equal to the linear correlation threshold, it means that the compression curve fitting effect does not meet the requirements, and an alarm reminder and a re-calibration reminder can be issued to the user through the interactive interface. When the user determines to calibrate again, the flow rate of the first standard solvent input into the liquid phase pump is re-executed to determine the positions of multiple stable opening points, determine the loss volumes corresponding to multiple system pressures, and then generate the compression curve of the solvent according to the multiple system pressures and loss volumes until the linear correlation of the compression curve is greater than the linear correlation threshold.

[0186] As another optional implementation, the expression formula and linear correlation of the compression curve are output through an interactive interface, and the user can judge whether the compression curve fitting effect meets the requirements based on the linear correlation. The interactive interface also includes confirmation and recalibration options. When the compression curve effect does not meet the requirements, the user can click the recalibration option to allow the control device to re-control the process of fitting and generating the compression curve of the solvent.

[0187] In this embodiment, by determining the flow rate of the first standard solvent, determining the positions of multiple stable opening points according to the pressure curve of the system pressure, and determining the loss volumes corresponding to multiple system pressures according to the positions of the multiple stable opening points, and then fitting the compression curve of the first standard solvent according to the multiple system pressures and the loss volumes corresponding to the system pressures, the solvent is compressed and corrected based on the liquid phase pump, and the compression curve is obtained for calling, so as to avoid the aging of the liquid phase pump and the lack of update of the compression curve, resulting in inaccurate opening point positions after calling the compression curve, large fluctuations in the output pulse of the liquid phase pump, and inaccurate detection results. And the compression curve of the newly added solvent is convenient for calling.

[0188] Further, Figure 8 This is a flow chart of determining the loss volume corresponding to multiple system pressures provided in an embodiment of the present application. Figure 8 This article introduces how to determine the loss volumes corresponding to multiple system pressures in the above steps.

[0189] S801: Set the correction point count to an initial value, and obtain a preset correction point quantity threshold.

[0190] Optionally, 1 may be set as the initial value of the correction point count. The larger the correction point number threshold is, the more correction times are, the more system pressure and loss volume are obtained, and the more accurate the compression curve generated by fitting is. Exemplarily, the preset correction point number threshold may be 10.

[0191] S802, setting the flow rate of the first standard solvent.

[0192] Optionally, the flow rate of the first standard solvent is set to adjust the system pressure of the first standard solvent in the liquid phase pump.

[0193] S803, adjusting the position of the current opening point, and determining whether the current opening point is stable according to the pressure curve of the system pressure of the liquid phase pump, if so, executing step S804, otherwise, re-executing step S803.

[0194] Optionally, determine whether the current opening point is stable based on the stability of the pressure curve of the system pressure of the liquid phase pump. If it is not stable, adjust the position of the current opening point and continue to judge whether the pressure curve is stable. If the pressure curve is stable, the current opening point is stable and step S804 can be executed.

[0195] It is worth noting that after setting the flow rate for the first standard solvent for the first time, a preset opening point position can be pre-set, and whether the current opening point is stable can be determined based on the pressure curve of the system pressure of the liquid phase pump. If so, execute step S804, otherwise, re-execute step S803.

[0196] S804, record the position of the current opening point and the current system pressure, determine the current loss volume according to the position of the current opening point, record the current system pressure and the current loss volume corresponding to the current system pressure, and update the correction point count.

[0197] Optionally, the current loss volume is calculated based on the position of the current opening point, the pump chamber cross section and the main discharge point position.

[0198] Optionally, each time step S804 is executed, the correction point count is incremented by one.

[0199] S805: Determine whether the calibration point count reaches the calibration point quantity threshold. If so, end the loop. If not, re-execute step S802.

[0200] Optionally, if the cycle is terminated, a compression curve is obtained by fitting the recorded multiple current system pressures and the current loss volumes corresponding to the multiple current system pressures.

[0201] In this embodiment, the flow rate of the first standard solvent is set, the current opening point position is adjusted to make the opening point position stable, the current loss volume is determined according to the current opening point position, and the cycle of the current system pressure and the current loss volume is recorded, so as to obtain multiple system pressures and loss volumes to generate a compression curve, thereby realizing solvent correction and ensuring the stability of the compression curve.

[0202] As an optional implementation, Fig. 9 Schematic diagram of the process of the solvent pre-calibration method provided in the embodiment of the present application. Fig. 9 As shown, after the user inputs the compression identifier, the liquid phase pump starts to pump liquid. The control module sets the correction point count as the initial value, obtains the correction point quantity threshold, sets the flow rate of the first standard solvent, adjusts the position of the current opening point to make the opening point stable, records the current opening point position and the current system pressure, and determines the current loss volume according to the current opening point position, records the current system pressure and the current loss volume corresponding to the current system pressure, and updates the correction point count. Determine whether the correction point count reaches the correction point quantity threshold. If not, execute the flow rate setting of the first standard solvent and subsequent steps. If so, fit and generate the compression curve of the first standard solvent according to multiple system pressures and the loss volumes corresponding to the system pressures, bind the compression identifier and the compression curve of the first standard solvent, and store the binding record in the memory.

[0203] Based on the same inventive concept, the embodiment of the present application also provides a liquid phase pump solvent compression correction device corresponding to the liquid phase pump solvent compression correction method. Since the principle of solving the problem by the device in the embodiment of the present application is similar to the above-mentioned liquid phase pump solvent compression correction method in the embodiment of the present application, the implementation of the device can refer to the implementation of the method, and the repeated parts will not be repeated.

[0204] Reference Fig.10 FIG. 1 is a schematic diagram of the structure of a liquid phase pump solvent compression correction device provided in an embodiment of the present application, wherein:

[0205] An acquisition module 1001 is used to acquire a compression identifier of a current solvent;

[0206] A determination module 1002 is used to determine whether the liquid phase pump has reached the position of the calculated opening point;

[0207] The first determination module 1003 is used to determine the target loss volume corresponding to the current solvent under the current system pressure according to the compression mark of the current solvent, the compression mark of at least one standard solvent in the binding record stored in the memory, and the compression curve corresponding to the compression mark of each standard solvent, wherein the compression curve is used to characterize the corresponding relationship between the system pressure and the loss volume;

[0208] The second determination module 1004 is used to determine the position of the target opening point according to the target loss volume;

[0209] The control module 1005 is used to control the operation of the liquid phase pump according to the position of the target opening point.

[0210] Optionally, the first determining module 1003 is specifically configured to:

[0211] Get the current system pressure;

[0212] Determining whether there is a target compression identifier that is the same as the compression identifier of the current solvent among the compression identifiers stored in the memory;

[0213] If yes, taking the compression curve of the target compression mark as the first compression curve, and determining the target loss volume according to the first compression curve and the current system pressure;

[0214] If not, the compression curves corresponding to the two compression marks adjacent to the compression mark of the current solvent in the memory are used as the second compression curve and the third compression curve, and the target loss volume is determined according to the second compression curve, the third compression curve and the current system pressure.

[0215] Optionally, the first determining module 1003 is specifically configured to:

[0216] The loss volume corresponding to the current system pressure in the first compression curve is used as the target loss volume.

[0217] Optionally, the first determining module 1003 is specifically configured to:

[0218] Using the loss volume corresponding to the current system pressure in the second compression curve as the first loss volume;

[0219] taking the loss volume corresponding to the current system pressure in the third compression curve as the second loss volume;

[0220] The target loss volume is determined according to the proportional relationship between the compression mark of the current solvent and two adjacent compression marks, as well as the first loss volume and the second loss volume.

[0221] Optionally, the first determining module 1003 is specifically configured to:

[0222] Taking the difference between the compression mark of the current solvent and the smallest compression mark of two adjacent compression marks as the first difference, and taking the difference between the two adjacent compression marks as the second difference;

[0223] taking a ratio of the first difference to the second difference as a target ratio;

[0224] Calculating the difference between the second loss volume and the first loss volume to obtain a third difference, wherein the second loss volume is greater than the first loss volume;

[0225] The product of the third difference and the target ratio, and the sum of the first loss volume are taken as the target loss volume.

[0226] Optionally, the acquisition module 1001 is further used for:

[0227] Determine the flow rate of the first standard solvent input into the liquid phase pump, determine the positions of a plurality of stable opening points according to the pressure curve of the system pressure of the liquid phase pump, and determine the loss volumes corresponding to a plurality of system pressures according to the positions of the plurality of stable opening points, wherein the stable opening points are used to characterize the stability of the pressure curve;

[0228] According to a plurality of system pressures and loss volumes corresponding to the system pressures, a compression curve of the first standard solvent is generated by fitting, a compression identifier and a compression curve of the first standard solvent are bound, and the binding record is stored in the memory.

[0229] Optionally, the acquisition module 1001 is further configured to:

[0230] A. Set the calibration point count to an initial value and obtain a preset calibration point quantity threshold;

[0231] B. setting the flow rate of the first standard solvent;

[0232] C. Adjust the position of the current opening point, and determine whether the current opening point is stable according to the pressure curve of the system pressure of the liquid phase pump. If so, execute step D, otherwise, re-execute step C;

[0233] D. Record the position of the current opening point and the current system pressure, determine the current loss volume according to the position of the current opening point, record the current system pressure and the current loss volume corresponding to the current system pressure, and update the correction point count;

[0234] E. Determine whether the calibration point count reaches the calibration point quantity threshold, if so, end the loop, if not, re-execute step B;

[0235] Optionally, the second determining module 1004 is specifically configured to:

[0236] Determine whether compensation is required;

[0237] If so, the position of the initial opening point is calculated according to the target loss volume, and a compensation value is determined according to a plurality of historical pressure curves of the liquid phase pump, and the position of the target opening point is determined according to the compensation value and the position of the initial opening point;

[0238] If not, the position of the target opening point is calculated based on the target loss volume.

[0239] For descriptions of the processing flow of each module in the device and the interaction flow between each module, reference may be made to the relevant descriptions in the above method embodiment, which will not be described in detail here.

[0240] The present application also provides a control device, such as Fig.111 is a schematic diagram of a control device provided in an embodiment of the present application, comprising: a processor 1101, a memory 1102 and a bus. The memory 1102 stores machine-readable instructions executable by the processor 1101 (for example, Fig.10 In the device, the acquisition module 1001, the judgment module 1002, the first determination module 1003, the second determination module 1004 and the execution instructions corresponding to the control module 1005, etc.), when the computer device is running, the processor 1101 communicates with the memory 1102 through a bus, and when the machine-readable instructions are executed by the processor 1101, the processing of the above-mentioned liquid phase pump solvent compression correction method is performed.

[0241] The embodiment of the present application also provides a liquid chromatograph, which includes a control device and a liquid phase pump, and the control device is connected to the liquid phase pump.

[0242] An embodiment of the present application further provides a computer-readable storage medium, on which a computer program is stored. When the computer program is executed by a processor, the steps of the above-mentioned liquid phase pump solvent compression correction method are executed.

[0243] Those skilled in the art can clearly understand that, for the convenience and simplicity of description, the specific working process of the system and device described above can refer to the corresponding process in the method embodiment, and will not be repeated in this application. In the several embodiments provided in this application, it should be understood that the disclosed system, device and method can be implemented in other ways. The device embodiments described above are merely schematic. For example, the division of the modules is only a logical function division. There may be other division methods in actual implementation. For example, multiple modules or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the mutual coupling or direct coupling or communication connection shown or discussed can be through some communication interfaces, indirect coupling or communication connection of devices or modules, which can be electrical, mechanical or other forms.

[0244] In addition, each functional unit in each embodiment of the present application can be integrated into a processing unit, or each unit can exist physically separately, or two or more units can be integrated into one unit. If the function is implemented in the form of a software functional unit and sold or used as an independent product, it can be stored in a computer-readable storage medium. Based on this understanding, the technical solution of the present invention is essentially or part of the technical solution that contributes to the prior art or part of the technical solution can be embodied in the form of a software product, and the computer software product is stored in a storage medium, including several instructions for a computer device (which can be a personal computer, a server, or a network device, etc.) to perform all or part of the steps of the method described in each embodiment of the present invention. The aforementioned storage medium includes: U disk, mobile hard disk, read-only memory (ROM, Read-Only Memory), random access memory (RAM, RandomAccess Memory), disk or optical disk and other media that can store program code.

[0245] The above are only specific implementation methods of the present application, but the protection scope of the present application is not limited thereto. Any technician familiar with the technical field can easily think of changes or substitutions within the technical scope disclosed in the present application, which should be covered by the protection scope of the present application.

Claims

1. A method for correcting solvent compression of a liquid phase pump, characterized in that: The method comprises: Obtaining a compression indicator of the current solvent, wherein the compression indicator is a compression coefficient of the current solvent; Determine whether the liquid phase pump has reached the position of the calculated opening point; If so, determine the target loss volume corresponding to the current solvent under the current system pressure according to the compression mark of the current solvent, the compression mark of at least one standard solvent in the binding record stored in the memory, and the compression curve corresponding to the compression mark of each standard solvent, wherein the compression curve is used to characterize the corresponding relationship between the system pressure and the loss volume, and the loss volume is the product of the displacement of the plunger rod from the main displacement point to the opening point and the cross-sectional area of ​​the pump chamber; Determine the position of the target opening point according to the target loss volume; The operation of the liquid phase pump is controlled according to the position of the target opening point.

2. The liquid phase pump solvent compression correction method according to claim 1, characterized in that: The step of determining a target loss volume corresponding to the current solvent under the current system pressure according to the compression identifier of the current solvent, the compression identifier of at least one standard solvent in the binding record stored in the memory, and the compression curves corresponding to the compression identifiers of the standard solvents includes: Get the current system pressure; Determining whether there is a target compression identifier that is the same as the compression identifier of the current solvent among the compression identifiers stored in the memory; If yes, taking the compression curve of the target compression mark as the first compression curve, and determining the target loss volume according to the first compression curve and the current system pressure; If not, the compression curves corresponding to the two compression marks adjacent to the compression mark of the current solvent in the memory are used as the second compression curve and the third compression curve, and the target loss volume is determined according to the second compression curve, the third compression curve and the current system pressure.

3. The liquid phase pump solvent compression correction method according to claim 2, characterized in that: The determining the target loss volume according to the first compression curve and the current system pressure comprises: The loss volume corresponding to the current system pressure in the first compression curve is used as the target loss volume.

4. The liquid phase pump solvent compression correction method according to claim 2, characterized in that: The determining the target loss volume according to the second compression curve, the third compression curve and the current system pressure comprises: Using the loss volume corresponding to the current system pressure in the second compression curve as the first loss volume; taking the loss volume corresponding to the current system pressure in the third compression curve as the second loss volume; The target loss volume is determined according to the proportional relationship between the compression mark of the current solvent and two adjacent compression marks, as well as the first loss volume and the second loss volume.

5. The liquid phase pump solvent compression correction method according to claim 4, characterized in that: Determining a target loss volume according to a proportional relationship between the compression mark of the current solvent and two adjacent compression marks, as well as the first loss volume and the second loss volume, includes: Taking the difference between the compression mark of the current solvent and the smallest compression mark of two adjacent compression marks as the first difference, and taking the difference between the two adjacent compression marks as the second difference; taking a ratio of the first difference to the second difference as a target ratio; Calculating the difference between the second loss volume and the first loss volume to obtain a third difference, wherein the second loss volume is greater than the first loss volume; The product of the third difference and the target ratio, and the sum of the first loss volume are taken as the target loss volume.

6. The liquid phase pump solvent compression correction method according to claim 1, characterized in that: Before obtaining the compression identifier of the current solvent, the method further includes: Determine the flow rate of the first standard solvent input into the liquid phase pump, determine the positions of a plurality of stable opening points according to the pressure curve of the system pressure of the liquid phase pump, and determine the loss volumes corresponding to a plurality of system pressures according to the positions of the plurality of stable opening points, wherein the stable opening points are used to characterize the stability of the pressure curve; According to a plurality of system pressures and loss volumes corresponding to the system pressures, a compression curve of the first standard solvent is generated by fitting, a compression identifier and a compression curve of the first standard solvent are bound, and the binding record is stored in the memory.

7. The liquid phase pump solvent compression correction method according to claim 6, characterized in that: The method of determining the flow rate of the first standard solvent input into the liquid phase pump, determining the positions of a plurality of stable opening points according to a pressure curve of a system pressure of the liquid phase pump, and determining the loss volumes corresponding to a plurality of system pressures according to the positions of the plurality of stable opening points, comprises: A. Set the calibration point count to an initial value and obtain a preset calibration point quantity threshold; B. setting the flow rate of the first standard solvent; C. Adjust the position of the current opening point, and determine whether the current opening point is stable according to the pressure curve of the system pressure of the liquid phase pump. If so, execute step D, otherwise, re-execute step C; D. Record the position of the current opening point and the current system pressure, determine the current loss volume according to the position of the current opening point, record the current system pressure and the current loss volume corresponding to the current system pressure, and update the correction point count; E. Determine whether the calibration point count reaches the calibration point quantity threshold. If so, end the loop. If not, re-execute step B.

8. The method for correcting solvent compression of a liquid phase pump according to claim 1, characterized in that: Determining the position of the target opening point according to the target loss volume includes: Determine whether compensation is required; If so, the position of the initial opening point is calculated according to the target loss volume, and a compensation value is determined according to a plurality of historical pressure curves of the liquid phase pump, and the position of the target opening point is determined according to the compensation value and the position of the initial opening point; If not, the position of the target opening point is calculated based on the target loss volume.

9. A control device, characterized in that: include: A processor and a memory, wherein the memory stores machine-readable instructions executable by the processor, and when the control device is running, the processor executes the machine-readable instructions to perform the steps of the liquid phase pump solvent compression correction method as described in any one of claims 1 to 8.

10. A liquid chromatograph, characterized in that: The liquid chromatograph comprises the control device as claimed in claim 9 and a liquid phase pump, wherein the control device is connected to the liquid phase pump.

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