Filling control method and device, sample analyzer and computer readable storage medium

Abstract

The invention relates to the technical field of biochemical detection, in particular to a filling control method, a filling device and a sample analyzer. The filling control method comprises the following steps: firstly, the conveying mechanism conveys a sample to be detected to the filling device; then, the filling device selectively executes at least one of a one-step method, a 1.5-step method, a two-step method and a 2.5-step method in a mixed mode according to the to-be-detected items of the samples, so that the reagent filling process is completed, in the process, the conveying mechanism continuously conveys the to-be-detected samples to the filling device, and the steps are repeatedly executed. According to the filling control method, the samples subjected to mixed detection can be subjected to mixed filling according to each sample and the one-step method, the 1.5-step method, the two-step method and the 2.5-step method, continuous filling items can be achieved, and the efficiency of filling different methodological items by equipment is effectively improved. The filling device realizes control of a reagent filling process. The sample analyzer and the computer readable storage medium help to guarantee the stability of the filling control method.

Description

Technical Field

[0001] The present invention relates to the technical field of biochemical detection, and in particular to a filling control method, a filling device and a sample analyzer. Background Art

[0002] In the field of biochemical testing, sample analyzers are the main equipment used for sample testing. In the process of biochemical testing of samples, reaction cups are required to load and transport analysis samples, and before testing, they undergo processes such as filling reagents, incubation, and washing. Furthermore, depending on the sample, the number of times the reagents are filled, as well as the incubation time and temperature, vary. In addition, based on the number of times the reagents are filled, the analysis process of the sample analyzer is divided into 1-step method, 1.5-step method, 2-step method, and 2.5-step method. The existing filling control method can only be compatible with the simultaneous mixed filling of the 1-step method and the 2-step method, and after filling, it will affect the filling project efficiency of the entire sample analyzer, thereby reducing the working efficiency of the equipment and causing errors in the filling process. The existing filling control method does not have a 1.5-step method and a 2.5-step method, and the sample analyzer cannot do these two projects.

[0003] In order to solve the above problems, it is urgent to provide a filling control method, a filling device and a sample analyzer. Summary of the invention

[0004] The purpose of the present invention is to propose a filling control method, a filling device and a sample analyzer to achieve 1-step method, 1.5-step method, 2-step method and 2.5-step method mixed filling, which can realize continuous filling projects and effectively improve the efficiency of equipment filling projects of different methodologies.

[0005] To achieve this object, the present invention adopts the following technical solutions: A filling control method, comprising: The conveying mechanism conveys the sample to be tested to the filling device; According to the items to be tested of the sample, the filling device selectively mixes and executes at least one of the 1-step method, the 1.5-step method, the 2-step method and the 2.5-step method; The filling device completes the reagent filling; and In the above process, the conveying mechanism continuously conveys the sample to be tested to the filling device, and repeats the above steps.

[0006] As an optional solution, according to the items to be tested of the sample, the filling device selectively mixes and executes at least one of the 1-step method, the 1.5-step method, the 2-step method and the 2.5-step method, including: The filling device performs a 1-step method; The filling device determines whether the item to be detected contains the 1.5-step method and the 2-step method items; and Determine whether to execute the subsequent steps corresponding to the 1.5-step method or the 2-step method according to the result of the judgment.

[0007] As an optional solution, if the judgment result of the filling device is that the item to be detected includes the item of step 1.5, the filling device executes the subsequent steps corresponding to step 1.5. After the filling device completes step 1.5, it further includes: The filling device determines whether the item to be detected exists in the 2.5-step method; and The filling device selectively executes the subsequent steps corresponding to the 2.5-step method or ends the filling of the reagent according to the judgment result.

[0008] As an optional solution, if the judgment result of the filling device is that the item to be detected has the two-step method item, the filling device executes subsequent steps corresponding to the two-step method. After the filling device completes the two-step method, it also includes: The filling device determines whether the item to be detected exists in the 2.5-step method; and The filling device selectively executes the subsequent steps corresponding to the 2.5-step method or ends the filling of the reagent according to the judgment result.

[0009] As an optional solution, if the judgment result of the filling device is that the item to be detected does not contain the 1.5-step method and the 2-step method item, it includes: The filling device determines whether the item to be detected exists in the 2.5-step method; and The filling device selectively executes the subsequent steps corresponding to the 2.5-step method or ends the filling of the reagent according to the judgment result.

[0010] As an optional solution, the 1-step method, 1.5-step method, 2-step method and 2.5-step method filling method include: At least one refill of reagent; and At least one incubation and / or wash.

[0011] As an optional scheme, an information code is set on the sample, the filling device completes the 1-step method, and when the sample is in the incubation or cleaning state, the filling device checks the information code and determines whether to execute the 1.5-step method, the 2-step method and the 2.5-step method according to the items to be tested of the corresponding sample.

[0012] As an optional solution, the filling device performs the 1.5-step method, the 2-step method and the 2.5-step method including: The filling device checks the status of the previous item of the 1.5-step method, the 2-step method and the 2.5-step method; Determine whether to execute the 1.5-step method, the 2-step method, and the 2.5-step method; If the filling device executes the step 1.5 method, the step 2 method, and the step 2.5 method, then searching for the corresponding item in the temporary table of the reagent bin where the filling device places the sample; Search by reagent information and check the search status; and If the filling device finds the corresponding reagent information, it checks the query result and fills the reagent.

[0013] As an optional solution, during the execution of the 1.5-step method, the 2-step method and the 2.5-step method, after the reagent is added, the steps include: The filling device stores the reagent filling information; Determine whether the temporary table status of the filling reagent can be found; If the temporary table state of the filling reagent cannot be found, the filling device sets the filling parameter to the state before the last filling of the reagent by the 1.5-step method, the 2-step method or the 2.5-step method; If the project status is wrong, the 1.5-step method, the 2-step method or the 2.5-step method is initialized; and The initialization information is recorded.

[0014] A filling device, comprising: a sample module configured to accommodate the sample; a sample suction module configured to extract a preset dose of the sample from the sample module; and A reagent extraction module configured to inject reagents into the sample The control mechanism is signal-connected to the sample module, the sample suction module and the reagent extraction module, and the control mechanism is used to determine whether to execute the 1-step method, the 1.5-step method, the 2-step method and the 2.5-step method.

[0015] A sample analyzer includes a memory and a processor. The memory stores a computer program. The processor is configured to execute the filling control method of the filling device as described above through the computer program.

[0016] A computer-readable storage medium stores a computer program, wherein the computer program executes the filling control method as described above when running.

[0017] The beneficial effects of the present invention are: The present invention provides a filling control method, which includes the following steps: first, a conveying mechanism conveys a plurality of samples to be tested to a filling device, and the conveying method here can be classified conveying or any mixed conveying, which is not limited in this embodiment. Then, the filling device selectively mixes and executes at least one of the 1-step method, 1.5-step method, 2-step method and 2.5-step method according to the items to be tested of the samples, thereby completing the reagent filling process. The filling control method can mix and fill the samples for mixed testing according to the items to be tested of each sample and the 1-step method, 1.5-step method, 2-step method and 2.5-step method, and can realize continuous filling of items, effectively improving the efficiency of the equipment in filling different methodological items.

[0018] The present invention also provides a filling device, which includes a sample module, a sample suction module and a reagent extraction module. The sample module is used to accommodate samples, the sample suction module is used to extract a preset dose of sample from the sample module, and the reagent extraction module can add reagents to the sample, thereby realizing the filling of reagents. Of course, the filling device also includes a control module, which is connected to the sample module, the sample suction module and the reagent extraction module by signal, and the control mechanism is used to determine whether to execute the 1-step method, the 1.5-step method, the 2-step method and the 2.5-step method, thereby controlling the reagent filling process.

[0019] The present invention also provides a sample analyzer, which includes a memory and a processor. The memory stores a computer program, and the processor is configured to execute a filling control method of a filling device through the computer program to ensure the stability of the filling control method.

[0020] The present invention also provides a computer-readable storage medium, in which a computer program is stored, wherein the above-mentioned filling control method is executed when the computer program is running to ensure the stability of the filling control method. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following briefly introduces the drawings required for use in the description of the embodiments of the present invention. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the contents of the embodiments of the present invention and these drawings without paying any creative work.

[0022] Figure 1 This is a logical diagram of the filling control method provided by the embodiment of the present invention. Figure 1 ; Figure 2 This is a logical diagram of the filling control method provided by the embodiment of the present invention. Figure 2 ; Figure 3It is a schematic diagram of the structure of the filling device provided in an embodiment of the present invention.

[0023] The following are marked in the figure: 100-sample module; 400-control agency; 200-sample suction module; 300-reagent extraction module. DETAILED DESCRIPTION

[0024] The present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It is to be understood that the specific embodiments described herein are only used to explain the present invention, rather than to limit the present invention. It should also be noted that, for ease of description, only partial structures related to the present invention are shown in the accompanying drawings, rather than the entire structure.

[0025] In the description of the present invention, unless otherwise clearly specified and limited, the terms "connected", "connected", and "fixed" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the connection of the internal structures of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0026] In the present invention, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may include that the first and second features are in direct contact, or may include that the first and second features are not in direct contact but are in contact through another feature between them. Moreover, a first feature being "above", "above" and "above" a second feature includes that the first feature is directly above and obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature. A first feature being "below", "below" and "below" a second feature includes that the first feature is directly below and obliquely below the second feature, or simply indicates that the first feature is lower in level than the second feature.

[0027] In the description of this embodiment, the terms "upper", "lower", "left", "right" and other directions or positional relationships are based on the directions or positional relationships shown in the drawings, and are only for the convenience of description and simplification of operation, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operate in a specific direction, and therefore cannot be understood as limiting the present invention. In addition, the terms "first" and "second" are only used to distinguish in the description and have no special meaning.

[0028] This embodiment provides a filling control method, which is applied to the process of sample analysis instrument testing samples. The process of sample analysis instrument testing samples generally involves firstly performing biochemical treatment on the samples by filling reagents to make them meet the testing conditions, and then performing testing to obtain the test results of the items to be tested.

[0029] Among them, the process of filling the sample is divided into 1-step method, 1.5-step method, 2-step method and 2.5-step method according to the number of times the reagent is filled. The existing filling control method can only be compatible with the mixed filling of 1-step method and 2-step method at the same time, and the filling will affect the filling efficiency of the entire sample analyzer, thereby reducing the working efficiency of the equipment and causing errors in the filling process. The existing filling control method does not have 1.5-step method and 2.5-step method, and the sample analyzer cannot do these two projects.

[0030] like Figure 1 As shown, in order to solve the above problem, the filling control method in this embodiment includes the following steps: First, the conveying mechanism conveys the sample to be tested to the filling device. The conveying method here can be classified conveying or any mixed conveying, which is not limited in this embodiment. Then, the filling device selectively mixes and executes at least one of the 1-step method, 1.5-step method, 2-step method and 2.5-step method according to the items to be tested of the sample, thereby completing the reagent filling process. At the same time, in the above process, the conveying mechanism continuously conveys the sample to be tested to the filling device and repeats the above steps. This filling control method can mix and fill the mixed test samples according to the items to be tested of each sample, and can realize continuous filling of items, which effectively improves the efficiency of the equipment in filling different methodological items.

[0031] Specifically, the filling methods of the 1-step method, the 1.5-step method, the 2-step method and the 2.5-step method include at least one reagent filling and at least one incubation and / or cleaning. Further, the steps of the 1-step method are the first filling of reagents and samples, incubation and cleaning. The steps of the 1.5-step method are the first filling of reagents and samples, incubation, cleaning and the second filling of reagents. The steps of the 2-step method are the first filling of reagents and samples, incubation, cleaning, the second filling of reagents, the second incubation and the second cleaning. The steps of the 2.5-step method are the first filling of reagents and samples, incubation, cleaning, the second filling of reagents, the second incubation, the second cleaning and the third filling of reagents. During the execution of the 1-step method, the 1.5-step method, the 2-step method and the 2.5-step method, the reagents mentioned here can be reagents of the same filling dosage and type, or different reagents, and this embodiment does not limit this.

[0032] It is understandable that the process time and temperature of sample incubation may be different, and the filling method used for the sample may also be different depending on the different items to be tested. The filling control method in this embodiment can optimize the filling method, time and filling position of different samples, sort the filling, and achieve the maximum test throughput of the filling device. Even when the sample is in the incubation waiting time, the filling control method can check the samples that have completed incubation and cleaning at any time and proceed to the next step, which is conducive to avoiding stopping the filling during the incubation or cleaning waiting time, thereby helping to improve the filling efficiency of the filling device.

[0033] Furthermore, in order to facilitate the filling device to determine the items to be detected by the sample, an information code is set on the sample, and the information code here can be any form of QR code, barcode or digital code, so that each sample has a one-to-one corresponding identity information. The filling device completes the 1-step method, and when the sample is in the incubation or cleaning state, the filling device checks the information code and determines whether to execute the 1.5-step method, the 2-step method and the 2.5-step method according to the items to be detected of the corresponding sample, so as to understand the items to be detected of each sample, which is conducive to the implementation of the filling control method of this embodiment and avoids errors, thereby improving the accuracy and stability of the filling control method.

[0034] Of course, after the sample has completed the reagent filling, the conveying mechanism can withdraw the sample from the filling device, thereby completing the entire process of the filling control method.

[0035] like Figure 2 As shown, further, according to the items to be detected of the sample, the filling device selectively mixes and executes at least one of the 1-step method, the 1.5-step method, the 2-step method and the 2.5-step method, and the specific method is: first, the filling device executes the 1-step method; the filling device determines whether there are 1.5-step and 2-step items in the items to be detected; and determines whether the subsequent steps corresponding to the 1.5-step method or the 2-step method are determined according to the result of the judgment. Since the 1-step method has steps that any filling method has, after the sample enters the filling device, the 1-step method can be executed first according to the items to be detected, and then the corresponding filling content of the subsequent 1.5-step method or the 2-step method can be performed. Of course, since the sample has completed the 1-step method, when executing the 1.5-step method or the 2-step method here, only the steps after the 1-step method need to be executed in sequence. This method is conducive to ensuring that the sample is filled with reagents in sequence, realizing the mixed filling of the 1-step method, the 1.5-step method, the 2-step method and the 2.5-step method, and the filling efficiency can be improved through the corresponding judgment of the filling device.

[0036] If the filling device determines that the item to be tested has a 1.5-step method, the filling device executes the subsequent steps corresponding to the 1.5-step method, thereby realizing the second filling of reagents. After completing the 1.5-step method, the filling device determines whether the item to be tested has a 2.5-step method, and selectively executes the subsequent steps corresponding to the 2.5-step method or ends the filling of reagents according to the determination result, realizing step-by-step determination according to the filling progress during the filling process, thereby avoiding omission of filling content, which is beneficial to improving the stability of the filling control method.

[0037] If the filling device determines that the item to be detected has a 2-step method, the filling device executes the subsequent steps corresponding to the 2-step method, thereby completing the second incubation and washing. After the filling device completes the 2-step method, the filling device determines whether the item to be detected has a 2.5-step method, and selectively executes the subsequent steps corresponding to the 2.5-step method or ends the filling of reagents according to the determination result, so as to realize step-by-step judgment according to the filling progress during the filling process, thereby avoiding the omission of filling content, which is conducive to improving the stability of the filling control method.

[0038] Of course, there is another situation where the filling device judges that there is no 1.5-step method and 2-step method for the item to be tested. Then the filling device judges whether there is a 2.5-step method for the item to be tested, and selectively executes the subsequent steps corresponding to the 2.5-step method or ends the filling of reagents based on the judgment result.

[0039] The filling device performs the 1.5-step method, the 2-step method and the 2.5-step method and further comprises the following steps: The filling device checks the status of the previous item of the 1.5-step method, the 2-step method, and the 2.5-step method, and determines whether to execute the 1.5-step method, the 2-step method, and the 2.5-step method. If the filling device executes the 1.5-step method, the 2-step method, and the 2.5-step method, then the filling device searches for the corresponding item in the temporary table of the reagent bin where the sample is placed; searches according to the reagent information, and checks the search status; if the filling device finds the corresponding reagent information, then checks the query results and fills the reagent. This method is beneficial to improving the accuracy of the filling process and avoiding filling errors by repeatedly reviewing the status of the sample and repeatedly querying the sample information and reagent information, which is beneficial to improving the accuracy and stability of the filling control method.

[0040] Furthermore, during the execution of the 1.5-step method, the 2-step method, and the 2.5-step method, after the reagent filling is completed, it also includes: the filling device saves the reagent filling information, and determines whether the temporary table status of the filling reagent can be found; if the temporary table status of the filling reagent cannot be found, the filling device sets the filling parameters to the previous state of the last reagent filling of the 1.5-step method, the 2-step method, or the 2.5-step method; if the project status is wrong, the 1.5-step method, the 2-step method, or the 2.5-step method is initialized; and the initialization information is recorded. That is, after each reagent filling, a record is made. When an error or failure occurs in the filling process, the filling device can check the sample according to the recorded information. If it can be corrected by adding reagents, it can continue. If it cannot be corrected, it is necessary to exit the filling device to restart the filling. This method continuously reviews the accuracy of the filling process and corrects errors in a timely manner. On the one hand, it can improve the filling efficiency and filling accuracy, and on the other hand, it can correct or exit in a timely manner after detecting an error.

[0041] See also Figure 3 In order to implement the above filling control method, this embodiment also proposes a filling device, which includes a sample module, a sample suction module and a reagent extraction module. The sample module is used to accommodate samples, the sample suction module is used to extract a preset dose of sample from the sample module, and the reagent extraction module can add reagents to the sample, thereby realizing the filling of reagents. Of course, the filling device also includes a control module, which is connected to the sample module, the sample suction module and the reagent extraction module by signal, and the control mechanism is used to determine whether to execute the 1-step method, the 1.5-step method, the 2-step method and the 2.5-step method, thereby controlling the reagent filling process.

[0042] In addition, this embodiment also provides a sample analyzer, which includes a memory and a processor. The memory stores a computer program, and the processor is configured to execute a filling control method of a filling device through the computer program to ensure the stability of the above filling control method.

[0043] A computer-readable storage medium stores a computer program, wherein the computer program executes the above-mentioned filling control method when it is run.

[0044] Note that the above shows and describes the basic principles and main features of the present invention and the advantages of the present invention. It should be understood by those skilled in the art that the present invention is not limited to the above embodiments, and the above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention to be protected, and the scope of the present invention to be protected is defined by the attached claims and their equivalents.

Claims

1. A filling control method, characterized in that: include: The conveying mechanism conveys the sample to be tested to the filling device; According to the items to be tested of the sample, the filling device selectively mixes and executes at least one of the 1-step method, the 1.5-step method, the 2-step method and the 2.5-step method; The filling device completes the reagent filling; and In the above process, the conveying mechanism continuously conveys the sample to be tested to the filling device, and repeats the above steps.

2. The filling control method according to claim 1, characterized in that: According to the items to be tested of the sample, the filling device selectively mixes and executes at least one of the 1-step method, the 1.5-step method, the 2-step method and the 2.5-step method, including: The filling device performs a 1-step method; The filling device determines whether the item to be detected contains the 1.5-step method and the 2-step method items; and Determine whether to execute the subsequent steps corresponding to the 1.5-step method or the 2-step method according to the result of the judgment.

3. The filling control method according to claim 2, characterized in that: If the determination result of the filling device is that the item to be detected includes the item of step 1.5, the filling device executes the subsequent steps corresponding to step 1.

5. After the filling device completes step 1.5, the filling device further includes: The filling device determines whether the item to be detected exists in the 2.5-step method; and The filling device selectively executes the subsequent steps corresponding to the 2.5-step method or ends the filling of the reagent according to the judgment result.

4. The filling control method according to claim 2, characterized in that: If the judgment result of the filling device is that the item to be detected contains the two-step method item, the filling device executes the subsequent steps corresponding to the two-step method. After the filling device completes the two-step method, it also includes: The filling device determines whether the item to be detected exists in the 2.5-step method; and The filling device selectively executes the subsequent steps corresponding to the 2.5-step method or ends the filling of the reagent according to the judgment result.

5. The filling control method according to claim 2, characterized in that: If the filling device determines that the item to be detected does not contain the 1.5-step method and the 2-step method item, the method includes: The filling device determines whether the item to be detected exists in the 2.5-step method; and The filling device selectively executes the subsequent steps corresponding to the 2.5-step method or ends the filling of the reagent according to the judgment result.

6. The filling control method according to claim 4, characterized in that: The 1-step method, 1.5-step method, 2-step method and 2.5-step method of filling include: At least one refill of reagent; and At least one incubation and / or wash.

7. The filling control method according to claim 6, characterized in that: An information code is set on the sample, and the filling device completes the 1-step method. When the sample is in the incubation or cleaning state, the filling device checks the information code and determines whether to execute the 1.5-step method, the 2-step method and the 2.5-step method according to the items to be tested of the corresponding sample.

8. The filling control method according to claim 1, characterized in that: The filling device performs the 1.5-step method, the 2-step method and the 2.5-step method, including: The filling device checks the status of the previous item of the 1.5-step method, the 2-step method and the 2.5-step method; Determine whether to execute the 1.5-step method, the 2-step method, and the 2.5-step method; If the filling device executes the step 1.5 method, the step 2 method, and the step 2.5 method, then searching for the corresponding item in the temporary table of the reagent bin where the filling device places the sample; Search by reagent information and check the search status; and If the filling device finds the corresponding reagent information, it checks the query result and fills the reagent.

9. The filling control method according to claim 8, characterized in that: During the execution of the 1.5-step method, the 2-step method and the 2.5-step method, after the reagent is added, the following steps are included: The filling device stores the reagent filling information; Determine whether the temporary table status of the filling reagent can be found; If the temporary table state of the filling reagent cannot be found, the filling device sets the filling parameter to the state before the last filling of the reagent by the 1.5-step method, the 2-step method or the 2.5-step method; If the project status is wrong, the 1.5-step method, the 2-step method or the 2.5-step method is initialized; and The initialization information is recorded.

10. A filling device, characterized in that: include: A sample module (100), configured to accommodate the sample; A sample suction module (200) configured to extract a preset dose of the sample from the sample module (100); and The reagent extraction module (300) is configured to inject the reagent into the sample The control mechanism (400) is signal-connected to the sample module (100), the sample suction module (200) and the reagent extraction module (300), and the control mechanism (400) is used to determine whether to execute the 1-step method, the 1.5-step method, the 2-step method and the 2.5-step method.

11. A sample analyzer, characterized in that: The sample analyzer comprises a memory and a processor, wherein a computer program is stored in the memory, and the processor is configured to execute the filling control method of the filling device according to any one of claims 1 to 9 through the computer program.

12. A computer-readable storage medium, characterized in that: The computer-readable storage medium stores a computer program, wherein the computer program executes the filling control method described in any one of items 1 to 9 when it is run.

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