Traditional Chinese medicine emulsion with scar removing effect and preparation method

Abstract

The invention provides a traditional Chinese medicine emulsion with a scar removing effect and a preparation method thereof. On the basis of the traditional Chinese medicine theory in China, the lavender essential oil is extracted from lavender serving as a raw material, traditional Chinese medicine ingredients such as baicalin, peppermint oil and linseed oil serve as main functional additives, and the lavender essential oil is prepared by combining common matrix ingredients in cosmetics. The scar-removing emulsion provided by the invention has the effects of resisting bacteria, fading scars, moistening skin and preserving moisture and the like. The scar-removing cosmetic is mild, non-irritant, healthy and safe, and can be widely applied to scar-removing cosmetics.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics, and particularly relates to a traditional Chinese medicine scar-removing emulsion and a preparation method thereof. Background Art

[0002] Hypertrophic scars are pathological scars caused by trauma, surgery, etc., characterized by excessive proliferation of fibroblasts and excessive deposition of extracellular matrix. They are a common skin disease, and their prevalence is on the rise worldwide. They appear as irregular, uneven, red, hard patches that are higher than the skin surface and generally do not exceed the damaged area. In addition to affecting appearance, hypertrophic scars may also cause discomfort such as pain, itching, and functional impairment, which has a great adverse effect on the patient's physical and mental health.

[0003] There are both traditional Chinese medicine and western medicine on the market. Western medicine treatments for this disease include surgery, drug injection, topical drug therapy, physical therapy, etc., but most of them have problems such as unsatisfactory efficacy, many adverse reactions and high recurrence rate. Traditional Chinese medicine treatments include external application of Chinese medicine, injection of Chinese medicine extracts, acupuncture, moxibustion and other treatment methods, which have disadvantages such as difficulty in operation. Summary of the invention

[0004] The purpose of the invention is to provide a traditional Chinese medicine skin care lotion with scar removing effect.

[0005] Another object of the present invention is to provide a method for preparing the above-mentioned traditional Chinese medicine skin care lotion, by extracting effective ingredients of traditional Chinese medicine and designing a process to prepare an emulsion that can effectively remove scars.

[0006] The inventive idea of ​​the present invention is:

[0007] The invention is based on the theory of traditional Chinese medicine, takes lavender as raw material, extracts lavender essential oil, and combines it with traditional Chinese medicine baicalin, peppermint oil, linseed oil, etc. to prepare an emulsion, which has the effects of antibacterial, scar fading, and skin moisturizing.

[0008] The present invention provides an emulsion containing effective ingredients of traditional Chinese medicine and having scar removal effect, comprising phase A and phase B, wherein phase A is composed of the following raw materials in percentage by weight:

[0009] Prescription drugs 1 wt% Carbomer 0.3~0.7 wt% Propylene glycol 3~5 wt% Triethanolamine 0.4~0.6 wt% Glycerol 4 wt% Deionized water balance

[0010] The B phase is composed of the following raw materials in weight percentage: Siban 60 4 wt% Olive oil 8 wt% Polydimethylsiloxane 1 wt% Tween 60 0.8~1.2 wt% Beeswax 1 wt% Glyceryl monostearate 5 wt% Methylparaben 0.2 wt% Propylparaben 0.1 wt%

[0011] Preferably, the prescription drug is prepared in a weight ratio of lavender essential oil: peppermint oil: baicalin: beeswax: linseed oil = 1:1:2:2:14.

[0012] The above-mentioned traditional Chinese medicine emulsion with scar removal effect, wherein the lavender essential oil is extracted from lavender raw medicinal materials.

[0013] Preferably, the extraction method is one of steam distillation, ultrasonic extraction, and organic solvent extraction, and more preferably steam distillation. The present invention uses the extraction rate and quality of lavender essential oil as indicators to select the final extraction method.

[0014] The lavender essential oil is extracted from lavender by steam distillation, and the specific extraction method comprises the following steps:

[0015] (1) Grind the lavender, put it into a round-bottom flask, add appropriate amount of water to fully soak the medicinal material, and soak for 2 h; (2) Connect the volatile oil analyzer and the spherical condenser, slowly heat to boiling, maintain a slight boiling state, and heat for 2 h (until the amount of essential oil no longer increases); (3) Pour it into a separatory funnel, add a small amount of sodium chloride, and let it stand for a while to separate the essential oil. Anhydrous sodium sulfide can be added to the essential oil to absorb water.

[0016] A method for preparing the above-mentioned traditional Chinese medicine emulsion with scar removal effect, wherein the method comprises the following steps:

[0017] (1) Phase A: Weigh carbomer, add half the volume of deionized water, stir thoroughly, and leave overnight. Heat the carbomer solution to 80°C, add propylene glycol, and maintain the temperature for 20 min. When the temperature drops to 50°C, add the remaining ingredients of phase A and make up the volume with deionized water.

[0018] (2) Phase B: Weigh all the raw materials of Phase B, mix and heat to 80°C, and maintain the temperature for 20 min;

[0019] (3) Add phase B to phase A, stir until emulsified, stop heating, cool to 40°C to 60°C, add the prescribed drug, and you are done.

[0020] The invention studies the optimal weight percentage of carbomer, propylene glycol, triethanolamine and Tween-60 as emulsion bases, and comprehensively scores the emulsion with the appearance, uniformity and spreadability as evaluation indexes, so as to adjust the material ratio.

[0021] Preferably, the weight percentage of carbomer in the emulsion matrix is ​​0.3, 0.4, 0.5, 0.6, or 0.7 wt%, and more preferably the weight percentage of carbomer is 0.5 wt%.

[0022] Preferably, the weight percentage of propylene glycol in the emulsion matrix is ​​3.0, 3.5, 4.0, 4.5, or 5.0 wt%, and more preferably the weight percentage of propylene glycol is 4.5 wt%.

[0023] Preferably, the weight percentage of triethanolamine in the emulsion matrix is ​​0.4, 0.45, 0.5, 0.55, or 0.6 wt%, and more preferably the weight percentage of triethanolamine is 0.5 wt%.

[0024] Preferably, the weight percentage of Tween-60 in the emulsion matrix is ​​0.8, 0.9, 1.0, 1.1, or 1.2 wt%, and more preferably the weight percentage of Tween-60 is 1.1 wt%.

[0025] Preferably, the amount of carbomer is 0.4, 0.5, 0.6 wt%, the amount of propylene glycol is 4.0, 4.5, 5.0 wt%, the amount of triethanolamine is 0.4, 0.5, 0.6 wt%, and the amount of Tween-60 is 1.0, 1.1, 1.2 wt%. More preferably, the amount of carbomer is 0.6%, the amount of propylene glycol is 5.0%, the amount of triethanolamine is 0.4%, and the amount of Tween-60 is 1.1%.

[0026] The preparation obtained by the above raw materials and method is a scar removing lotion. According to different usage routes, the Chinese medicine mixture of the present invention can be made into other external skin care preparations, such as creams, sprays or essences, but is not limited to the above dosage forms.

[0027] The recommended method of using the lotion of the present invention is: after cleansing the face every day, apply the scar removing lotion on the skin with scars, massage gently, and wait for the lotion to be slowly absorbed.

[0028] Beneficial effects of the present invention:

[0029] The raw materials of the present invention are natural plant ingredients, which are safe and non-irritating to the skin. The prescription Chinese medicine itself has the effects of analgesia, antispasmodic, antibacterial and anti-inflammatory, tissue regeneration and skin moisturizing, and especially has the effect of removing scars. The raw materials of the present invention are easy to obtain, the preparation method is simple, green and safe, the scar removal effect is good, the acceptance of consumers is high, and it has a good application prospect and market prospect. DETAILED DESCRIPTION

[0030] In order to make the objectives, technical solutions and advantages of the present invention more clear, the present invention is further described in detail below in conjunction with specific implementation methods.

[0031] Example 1 Preparation of emulsions with different amounts of carbomer

[0032] (1) Phase A: Weigh different amounts of carbomer (0.3, 0.4, 0.5, 0.6, 0.7 wt%), add half the volume of deionized water, stir well, and leave overnight. Heat the carbomer solution to 80°C, add propylene glycol, and maintain the temperature for 20 min. When the temperature drops to 50°C, add the remaining ingredients of phase A and make up the volume with deionized water.

[0033] (2) Phase B: Weigh all the raw materials of Phase B, mix and heat to 80°C, and maintain the temperature for 20 min;

[0034] (3) Add phase B to phase A, stir until emulsified, stop heating, cool to 40°C to 60°C, add the prescribed drug, and you are done.

[0035] Table 1 Effects of different carbomer dosages on the indicators of traditional Chinese medicine emulsion Carbomer dosage (wt%) Appearance Uniformity Spreadability Overall Rating 0.3 Milky white, thin texture No particles Difficult to apply 4.3 0.4 Milky white, thin texture No particles General coating 7.3 0.5 Milky white, medium texture No particles Easy to spread 9.3 0.6 Milky white, viscous texture A small amount of particles General coating 7.5 0.7 Milky white, viscous texture A small amount of particles General coating 7.3

[0036] The above results show that when the dosage of carbomer is 0.5%, the obtained emulsion is uniform milky white, does not stick to the wall after shaking, and has the best ductility and uniformity.

[0037] Example 2 Preparation of emulsions with different amounts of propylene glycol

[0038] (1) Phase A: Weigh carbomer, add half the volume of deionized water, stir thoroughly, and leave overnight. Heat the carbomer solution to 80°C, add different amounts of propylene glycol (3.0, 3.5, 4.0, 4.5, 5.0 wt%), and maintain the temperature for 20 min. When the temperature drops to 50°C, add the remaining ingredients of phase A and make up the volume with deionized water.

[0039] (2) Phase B: Weigh all the raw materials of Phase B, mix and heat to 80°C, and maintain the temperature for 20 min;

[0040] (3) Add phase B to phase A, stir until emulsified, stop heating, cool to 40°C to 60°C, add the prescribed drug, and you are done.

[0041] Table 2 Effects of different propylene glycol dosages on the indicators of traditional Chinese medicine emulsion Propylene glycol (wt%) Appearance Uniformity Spreadability Overall Rating 3.0 Milky white, milky No particles General coating 7.8 3.5 Milky white, milky No particles General coating 8.5 4.0 Milky white, milky No particles Easy to spread 9.0 4.5 Milky white, milky A small amount of particles Easy to spread 9.5 5.0 Milky white, milky A small amount of particles General coating 8.8

[0042] The above results show that when the dosage of propylene glycol is 4.5%, the appearance, uniformity and spreadability of the emulsion are the best, and the comprehensive score is the highest.

[0043] Example 3 Preparation of emulsions with different amounts of triethanolamine

[0044] (1) Phase A: Weigh carbomer, add half the volume of deionized water, stir thoroughly, and leave overnight. Heat the carbomer solution to 80°C, add propylene glycol, and maintain the temperature for 20 min. When the temperature drops to 50°C, add the remaining ingredients of phase A and make up the volume with deionized water, and add different amounts of triethanolamine (0.40, 0.45, 0.50, 0.55, 0.60 wt%).

[0045] (2) Phase B: Weigh all the raw materials of Phase B, mix and heat to 80°C, and maintain the temperature for 20 min;

[0046] (3) Add phase B to phase A, stir until emulsified, stop heating, cool to 40°C to 60°C, add the prescribed drug, and you are done.

[0047] Table 3 Effects of different triethanolamine dosages on the indicators of traditional Chinese medicine emulsion Triethanolamine dosage (wt%) Appearance Uniformity Spreadability Overall Rating 0.40 Milky white, thin texture A small amount of particles Unable to paint 4.8 0.45 Milky white, thin texture No particles General coating 6.5 0.50 Milky white, medium texture No particles Easy to spread 9.5 0.55 Milky white, viscous texture No particles Easy to spread 9.0 0.60 Milky white, viscous texture No particles Easy to spread 9.3

[0048] The above results show that when the dosage of triethanolamine is 0.5%, the appearance, uniformity and spreadability of the emulsion are the best, and the comprehensive score is the highest.

[0049] Example 4 Preparation of emulsions with different amounts of Tween-60

[0050] (1) Phase A: Weigh carbomer, add half the volume of deionized water, stir thoroughly, and leave overnight. Heat the carbomer solution to 80°C, add propylene glycol, and maintain the temperature for 20 min. When the temperature drops to 50°C, add the remaining ingredients of phase A and make up the volume with deionized water.

[0051] (2) Phase B: Weigh the raw materials of phase B, add different amounts of Tween-60 (0.8, 0.9, 1.0, 1.1, 1.2 wt%), mix and heat to 80 °C, and maintain the temperature for 20 min;

[0052] (3) Add phase B to phase A, stir until emulsified, stop heating, cool to 40°C to 60°C, add the prescribed drug, and you are done.

[0053] Table 4 Effects of different Tween-60 dosages on the indicators of traditional Chinese medicine emulsion Tween-60 dosage (wt%) Appearance Uniformity Spreadability Overall Rating 0.8 Milky white, milky A small amount of particles General coating 6.3 0.9 Milky white, milky A small amount of particles General coating 7.5 1.0 Milky white, milky A small amount of particles Easy to spread 8.0 1.1 Milky white, milky No particles Easy to spread 9.5 1.2 Milky white, milky No particles Easy to spread 8.5

[0054] The above results show that when the dosage of Tween-60 is 1.1%, the appearance, uniformity and spreadability of the emulsion are the best, and the comprehensive score is the highest.

[0055] Example 5

[0056] The weight percentages of the emulsion matrix carbomer, propylene glycol, triethanolamine, and Tween-60 in the formula are 0.5 wt%, 4.5 wt%, 0.5 wt%, and 1.1 wt%, respectively. However, this ratio is not necessarily the best ratio for the molding effect of the emulsion. Therefore, the present invention further optimizes the ratio and prepares the emulsion according to different weight ratios. The method is as follows:

[0057] (1) Phase A: Weigh carbomer, add half the volume of deionized water, stir thoroughly, and leave overnight. Heat the carbomer solution to 80°C, add propylene glycol, and maintain the temperature for 20 min. When the temperature drops to 50°C, add the remaining ingredients of phase A and make up the volume with deionized water.

[0058] (2) Phase B: Weigh all the raw materials of Phase B, mix and heat to 80°C, and maintain the temperature for 20 min;

[0059] (3) Add phase B to phase A, stir until emulsified, stop heating, cool to 40°C to 60°C, add the prescribed drug, and you are done.

[0060] Table 5 Effects of different matrix dosage ratios on the indicators of traditional Chinese medicine emulsion

[0061] The above results show that the optimal molding preparation process of traditional Chinese medicine scar removal lotion is: the dosage of carbomer is 0.6%, the dosage of propylene glycol is 5.0%, the dosage of Tween-60 is 1.1%, and the dosage of triethanolamine is 0.4%. Under this condition, the appearance, uniformity, stability and spreadability of the traditional Chinese medicine scar removal lotion are the best.

[0062] Example 6 Preparation of the emulsion of the present invention

[0063] Raw materials and proportions (mass percentage), see Table 6:

[0064] Table 6

[0065] The emulsion was prepared according to the raw material ratio in Table 6, and the steps were as follows:

[0066] (1) Phase A: Weigh carbomer, add half the volume of deionized water, stir thoroughly, and leave overnight. Heat the carbomer solution to 80°C, add propylene glycol, and maintain the temperature for 20 min. When the temperature drops to 50°C, add the remaining ingredients of phase A and make up the volume with deionized water.

[0067] (2) Phase B: Weigh all the raw materials of Phase B, mix and heat to 80°C, and maintain the temperature for 20 min;

[0068] (3) Add phase B to phase A, stir until emulsified, stop heating, cool to 40°C to 60°C, add the prescribed drug, and you are done.

[0069] The following physical and chemical tests were performed on Example 6:

[0070] 1. Properties

[0071] The emulsion prepared by the invention is milky white, has appropriate viscosity, is fine and uniform, has good spreadability, is cool and comfortable, and has good stability.

[0072] 2. pH value check

[0073] Take one part of the traditional Chinese medicine emulsion, add nine parts of distilled water, heat to 40℃, and stir continuously until uniform, cool to the specified temperature, measure the pH value 3 times with a pH meter, the average value is 6.93, which meets the national standard.

[0074] 3. Hot and cold test

[0075] The emulsion was placed in a -20℃ refrigerator for 24 hours, and there was no stratification or discoloration. The emulsion was placed in a 40℃ constant temperature box for 24 hours, and there was no stratification or taste change.

[0076] 4. Centrifugal test

[0077] The emulsion was placed in a centrifuge tube and centrifuged at 2000 r / min for 30 min without stratification or agglomeration.

[0078] 5. Bacteria detection

[0079] The diluted emulsion was inoculated on an agar plate and cultured in a 37°C incubator for 48 hours. The total number of bacteria in the emulsion was 128 cfu / mL, which met the cosmetic hygiene standards. The emulsion was inoculated on a blood agar plate and cultured in a constant temperature incubator. After 36 hours, no Staphylococcus aureus and Pseudomonas aeruginosa colonies were found, indicating an antibacterial effect.

[0080] 6. Irritation test

[0081] Cut off about 2.5 cm of hair on the side of the mouse spine 2 , rest for 24 hours, and after the irritation caused by shaving has healed, take 0.5 g of the lotion and apply it evenly on the shaved area. Apply it once a day, wash off the lotion with clean water after 24 hours of application, and apply it for the second time after shaving. Apply it in this way for 14 days continuously. During this period, there will be no redness, rash, blisters, etc. on the skin.

[0082] 7. Efficacy test

[0083] 7.1 Test materials

[0084] Chinese medicine scar removal lotion, polysulfonated mucopolysaccharide cream, 8% sodium sulfide, 1% chloral hydrate solution. 18 Kunming mice, 6-8 weeks old, half male and half female, with a body weight of 22-25g, were obtained from the Experimental Animal Center of Xinjiang Medical University.

[0085] 7.2 Grouping of mice: model group, mucopolysaccharide polysulfate group, and emulsion group

[0086] 7.3 Mouse modeling

[0087] (1) Mice were anesthetized by intraperitoneal injection of 10% chloral hydrate (400 mg / kg), and 8% sodium sulfide solution was used to depilate a 2 cm × 4 cm area on the upper back.

[0088] (2) After 24 hours, the mouse hair removal area was disinfected with 70% ethanol topically. The water temperature in the constant temperature water bath was raised to 95°C. The hair removal area of ​​the mouse was placed 10 cm above the steam outlet and removed after 10 seconds. The scalded area was equal to the hair removal area.

[0089] (3) After modeling, 0.5 mL of normal saline was injected intraperitoneally into the mice to prevent shock.

[0090] 7.4 Treatment options

[0091] The model group was massaged with a 2 mL saline cotton swab, the polysulfated mucopolysaccharide group was massaged with a 2 g Hi-Liao-Tu ointment cotton swab, and the lotion group was massaged with a 2 g lavender lotion cotton swab. The treatment was given twice a day, with an interval of 12 hours, for 28 consecutive days.

[0092] 7.5 Results Analysis

[0093] After 3 days of treatment with the Chinese medicine lotion, the inflammatory response was alleviated. After 7 days of treatment with the lotion, granulation tissue was visible in the lesions without exudation. After 28 days of treatment with the lotion, the lesions were relatively clean, the scabs fell off in large quantities, and the wound surface was basically healed.

[0094] Wound healing rate (%) = (original wound area - residual wound area) / original wound area × 100%, see Table 7

[0095] Table 7 Wound healing rate of mice Time / d Lavender lotion set Polysaccharide group Model Group 1 <![CDATA[128 mm 2 ]]> <![CDATA[128 mm 2 ]]> <![CDATA[128 mm 2 ]]> 5 18.7% 18.0% 14.1% 14 42.3% 42.8% 31.8% 20 66.7% 55.0% 36.6% 28 82.4% 64.4% 42.4%

[0096] 7.6 Conclusion

[0097] The traditional Chinese medicine scar-removing lotion of the present invention can obviously improve the condition of the target skin. As the use time of the lotion increases, the improvement effect gradually increases, and the scar-removing lotion has a good scar-removing effect.

[0098] 8. Sensory evaluation

[0099] The sensory evaluation test was conducted by questionnaire survey, and the volunteers' feelings were recorded from seven aspects: spreadability, moisturizing, permeability, stickiness, greasiness, direct use and later use. The results are shown in Table 8.

[0100] Table 8 Sensory evaluation questionnaire results name Options Frequency (person) frequency age 17-24 years old 25-31 years old 32-38 years old 38-44 years old 45-50 years old 5489331911 26.21%43.2%16.02%9.22%5.34% Skin Type Dry type Oil type Combination type 626876 30.1%33.01%36.89% Whether there is scar whether 83123 40.29%59.71% Hydration Very good Very good Good Average 67823720 32.52%39.81%17.96%9.71% Ductility Very good Good Average Poor 66873815 32.04%42.23%18.45%7.28% odor Very good good 1176326 56.8%30.58%12.62% Efficacy Good Good Average 1245329 60.19%25.73%14.08% Are there any allergies? whether 8184 4.17%95.83% Satisfaction 1-10 points Average score: 8.27

[0101] In summary, the Chinese medicine scar removal lotion prepared by the present invention can effectively repair and improve scars, has a good effect on hypertrophic scars, adopts a Chinese medicine formula, is mild and non-irritating, and has good antibacterial and anti-inflammatory, skin-moistening and moisturizing effects.

Claims

1. A lotion containing effective ingredients of traditional Chinese medicine and having scar removal effect, characterized in that: The traditional Chinese medicine emulsion comprises phase A and phase B, and phase A is composed of the following raw materials in percentage by weight: Prescription drugs 1 wt% Carbomer 0.3~0.7 wt% Propylene glycol 3~5 wt% Triethanolamine 0.4~0.6 wt% Glycerol 4 wt% Deionized water balance The B phase is composed of the following raw materials in weight percentage: Siban 60 4 wt% Olive oil 8 wt% Polydimethylsiloxane 1 wt% Tween 60 0.8~1.2 wt% Beeswax 1 wt% Glyceryl monostearate 5 wt% Methylparaben 0.2 wt% Propylparaben 0.1 wt% The prescription drug is prepared in a weight ratio of lavender essential oil: peppermint oil: baicalin: beeswax: linseed oil = 1:1:2:2:

14.

2. The Chinese medicine emulsion according to claim 1, characterized in that, The lavender essential oil is extracted from lavender raw medicinal materials.

3. Lavender essential oil according to claim 2, characterized in that The extraction method is one of a steam distillation method, an ultrasonic extraction method and an organic solvent extraction method.

4. The lavender essential oil according to claim 3, characterized in that: The extraction method is steam distillation.

5. The extraction method according to claim 4, characterized in that: The specific extraction method includes the following steps: (1) Grind the lavender, put it into a round-bottom flask, add appropriate amount of water to fully soak the medicinal material, and soak for 2 h; (2) Connect the volatile oil analyzer and the spherical condenser, slowly heat to boiling, keep it at a slight boiling state, and heat for 2 h (until the amount of essential oil no longer increases); (3) Pour into a separatory funnel, add a small amount of sodium chloride, and let it stand for a while to separate the essential oil. Anhydrous sodium sulfide can be added to the essential oil to absorb water.

6. A method for preparing the traditional Chinese medicine emulsion according to claim 1, characterized in that: The method comprises the following steps: (1) Phase A: Weigh carbomer, add half the volume of deionized water, stir thoroughly, and leave overnight. Heat the carbomer solution to 80°C, add propylene glycol, and maintain the temperature for 20 min. When the temperature drops to 50°C, add the remaining ingredients of phase A and make up the volume with deionized water. (2) Phase B: Weigh all the raw materials of phase B, mix and heat to 80°C, and maintain the temperature for 20 min; (3) Add phase B to phase A, stir until emulsified, stop heating, cool to 40°C to 60°C, add the prescribed drug, and you are done.

7. The preparation method according to claim 6, characterized in that: The weight percentage of the emulsion matrix carbomer is 0.3-0.7 wt %, the weight percentage of propylene glycol is 3-5 wt %, the weight percentage of triethanolamine is 0.4-0.6 wt %, and the weight percentage of Tween-60 is 0.8-1.2 wt %.

8. The preparation method according to claim 6, characterized in that: The weight percentage of the emulsion matrix carbomer is 0.6 wt %, the weight percentage of propylene glycol is 5 wt %, the weight percentage of triethanolamine is 0.4 wt %, and the weight percentage of Tween-60 is 1.1 wt %.

9. A Chinese medicine emulsion with scar removal effect, characterized in that: The traditional Chinese medicine emulsion is prepared by the method of claim 6 and the emulsion matrix of claim 8 in a weight ratio.

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